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| 1 | Transplantation of collagen scaffold with autologous bone marrow mononuclear cells promotes functional endometrium reconstruction via downregulating ΔNp63 expression in Asherman's syndrome显示文摘Asherman's syndrome(AS) is a common disease that presents endometrial regeneration disorder. However, little is known about its molecular features of this aregenerative endometrium in AS and how to reconstruct the functioning endometrium for the patients with AS. Here, we report that ΔNp63 is significantly upregulated in residual epithelial cells of the impaired endometrium in AS; the upregulated-ΔNp63 induces endometrial quiescence and alteration of stemness. Importantly, we demonstrate that engrafting high density of autologous bone marrow mononuclear cells(BMNCs) loaded in collagen scaffold onto the uterine lining of patients with AS downregulates ΔNp63 expression, reverses ΔNp63-induced pathological changes, normalizes the stemness alterations and restores endometrial regeneration. Finally, five patients achieved successful pregnancies and live births. Therefore, we conclude that ΔNp63 is a crucial therapeutic target for AS. This novel treatment significantly improves the outcome for the patients with severe AS. | Guangfeng Zhao Yun Cao Xianghong Zhu Xiaoqiu Tang Lijun Ding Haixiang Sun Juan Li Xinan Li Chenyan Dai Tong Ru Hui Zhu Jingjie Lu Caimei Lin Jingmei Wang Guijun Yan Huiyan Wang Lei Wang Yimin Dai Bin Wang Ruotian Li Jianwu Dai Yan Zhou Yali Hu | 2017 | Science China(Life Sciences)2017，60，4： | 39 |
| 2 | Polymer-based EMI shielding composites with 3D conductive networks:A mini-review显示文摘High-frequency electromagnetic waves and electronic products can bring great convenience to people’s life,but lead to a series of electromagnetic interference(EMI)problems,such as great potential dangers to the normal operation of elec-tronic components and human safety.Therefore,the research of EMI shield-ing materials has attracted extensive attention by the scholars.Among them,polymer-based EMI shielding materials with light weight,high specific strength,and stable properties have become the current mainstream.The construction of 3D conductive networks has proved to be an effective method for the prepara-tion of polymer-based EMI shielding materials with excellent shielding effective-ness(SE).In this paper,the shielding mechanism of polymer-based EMI shield-ing materials with 3D conductive networks is briefly introduced,with emphasis on the preparation methods and latest research progress of polymer-based EMI shielding materials with different 3D conductive networks.The key scientific and technical problems to be solved in the field of polymer-based EMI shielding materials are also put forward.Finally,the development trend and application prospects of polymer-based EMI shielding materials are prospected. | Lei Wang Zhonglei Ma Yali Zhang Lixin Chen Dapeng Cao Junwei Gu | 2021 | SusMat2021，1，3： | 22 |
| 3 | Eleven COVID-19 Outbreaks with Local Transmissions Caused by the Imported SARS-CoV-2 Delta VOC-China,July-August,2021显示文摘Starting from December 2019,Wuhan,China,encountered the first outbreak of coronavirus disease 2019(COVID-19)(1-2).The epidemic was successfully suppressed by strict containment so that the number of infected people was reduced to 0 on April 8,2020(3–4).After that,China experienced roughly 3 dozen outbreaks with local transmission caused by imported severe acute respiratory syndrome coronavirus 2(SARS-CoV-2). | Lei Zhou Kai Nie Hongting Zhao Xiang Zhao Bixiong Ye Ji Wang Cao Chen Hong Wang Jiangli Di Jinsong Li Chao Li Zhixiao Chen Ruiqi Ren Peihua Niu Hui Chen Tao Chen Yali Wang Lili Li Bingxue Han Ruhan A Si Chen Dan Li Dan Li Chunxia Jin Xin Zhang Jiangmei Liu Chunyu Xu Yecheng Yao Yenan Feng Zhili Li Bike Zhang Yang Song Peter Hao Yanping Zhang Hao Li Qun Li George F.Gao Guoqing Shi Wenbo Xu | 2021 | China CDC weekly2021，3，41： | 13 |
| 4 | Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines显示文摘SARS-CoV-2 variants could induce immune escape by mutations on the receptor-binding domain(RBD)and N-terminal domain(NTD).Here we report the humoral immune response to circulating SARS-CoV-2 variants,such as 501Y.V2(B.1.351),of the plasma and neutralizing antibodies(NAbs)elicited by CoronaVac(inactivated vaccine),ZF2001(RBD-subunit vaccine)and natural infection.Among 86 potent NAbs identified by high-throughput single-cell VDJ sequencing of peripheral blood mononuclear cells from vaccinees and convalescents,near half anti-RBD NAbs showed major neutralization reductions against the K417N/E484K/N501Y mutation combination,with E484K being the dominant cause.VH3-53/VH3-66 recurrent antibodies respond differently to RBD variants,and K417N compromises the majority of neutralizing activity through reduced polar contacts with complementarity determining regions.In contrast,the 242–244 deletion(242–244Δ)would abolish most neutralization activity of anti-NTD NAbs by interrupting the conformation of NTD antigenic supersite,indicating a much less diversity of anti-NTD NAbs than anti-RBD NAbs.Plasma of convalescents and CoronaVac vaccinees displayed comparable neutralization reductions against pseudo-and authentic 501Y.V2 variants,mainly caused by E484K/N501Y and 242–244Δ,with the effects being additive.Importantly,RBD-subunit vaccinees exhibit markedly higher tolerance to 501Y.V2 than convalescents,since the elicited anti-RBD NAbs display a high diversity and are unaffected by NTD mutations.Moreover,an extended gap between the third and second doses of ZF2001 leads to better neutralizing activity and tolerance to 501Y.V2 than the standard three-dose administration.Together,these results suggest that the deployment of RBD-vaccines,through a third-dose boost,may be ideal for combating SARS-CoV-2 variants when necessary,especially for those carrying mutations that disrupt the NTD supersite. | Yunlong Cao Ayijiang Yisimayi Yali Bai Weijin Huang Xiaofeng Li Zhiying Zhang Tianjiao Yuan Ran An Jing Wang Tianhe Xiao Shuo Du Wenping Ma Liyang Song Yongzheng Li Xiang Li Weiliang Song Jiajing Wu Shuo Liu Xuemei Li Yonghong Zhang Bin Su Xianghua Guo Yangyang Wei Chuanping Gao Nana Zhang Yifei Zhang Yang Dou Xiaoyu Xu Rui Shi Bai Lu Ronghua Jin Yingmin Ma Chengfeng Qin Youchun Wang Yingmei Feng Junyu Xiao Xiaoliang Sunney Xie | 2021 | Cell Research2021，31，7： | 12 |
| 5 | Au-Ag alloy nanoparticles with tunable cavity for plasmon-enhanced photocatalytic H2 evolution显示文摘Au-Ag alloy nanoparticles with different cavity sizes have great potential for improving photocatalytic performance due to their tunable plasmon effect.In this study,galvanic replacement was combined with co-reduction with the reaction kinetics processes regulated to rapidly synthesize Au-Ag hollow alloy nanoparticles with tunable cavity sizes.The position of the localized surface plasmon resonance(LSPR)peak could be effectively adjusted between 490 nm and 713 nm by decreasing the cavity size of the Au-Ag hollow nanoparticles from 35 nm to 20 nm.The plasmon-enhanced photocatalytic H2 evolution of alloy nanoparticles with different cavity sizes was investigated.Compared with pure P25(TiO2),intact and thin-shelled Au-Ag hollow nanoparticles(HNPs)-supported photocatalyst exhibited an increase in the photocatalytic H2 evolution rate from 0.48μmol h^−1 to 4μmol h^−1 under full-spectrum irradiation.This improved photocatalytic performance was likely due to the plasmon-induced electromagnetic field effect,which caused strong photogenerated charge separation,rather than the generation of hot electrons. | Xuanyu Yue Juan Hou Haifeng Zhao Pengcheng Wu Yali Guo Qin Shi Long Chen Shanglong Peng Zhiyong Liu Guozhong Cao | 2020 | Journal of Energy Chemistry2020，29，10： | 4 |
| 6 | Structure-based design of conformationally constrained cyclic peptidomimetics to target the MLL1-WDR5 protein–protein interaction as inhibitors of the MLL1 methyltransferase activity显示文摘We described herein structure-based design,synthesis and evaluation of conformationally constrained,cyclic peptidomimetics to block the MLL1-WDR5 protein–protein interaction as inhibitors of the MLL1 histone methyltransferase activity.Our study has yielded cyclic peptidomimetics with very high binding affinities to WDR5(Kivalues <1 nmol/L) and function as antagonists of the MLL1 histone methyltransferase activity. | Hacer Karatas Shirley Y.Lee Elizabeth C.Townsend Fang Cao Jing Xu Denzil Bernard Liu Liu Yali Dou Shaomeng Wang | 2015 | Chinese Chemical Letters2015，26，4： | 3 |
| 7 | Dark current mechanism of unpassivated mid wavelength type II InAs/GaSb superlattice infrared photodetector显示文摘We investigate the dark current mechanism for an unpassivated mid wavelength(MW) type II InAs/GaSb superlattice infrared photodetector by doing the variablearea diode tests. The bulk resistance-area product and the resistivity due to the surface current are determined to be17.72 X cm2 and 704.23 X cm at 77 K, respectively. It is found that for all the mesa sizes used, the dark current is dominated or predominated by the surface component, and with scaling back the mesa size, the surface current increases while the bulk component decreases. The activation energy is determined to be 145 meV for the temperature range around 140–280 K, while it is 6 meV when temperature is below 100 K. It is also found that the dark current is dominated by the generation-recombination current for the MW device when temperature is between140 and 280 K. | Qiong Li Wenquan Ma Yanhua Zhang Kai Cui Jianliang Huang Yang Wei Ke Liu Yulian Cao Weiying Wang Yali Liu Peng Jin | 2014 | Chinese Science Bulletin2014，59，28： | 3 |
| 8 | Development and Application of a Regional Land Subsidence Model for the Plain of Tianjin显示文摘In this paper, a coupled numerical groundwater and land subsidence model was developed for the Tianjin Plain. The model was employed to investigate the groundwater resources and their changes over the last decade, and to further predict the changing patterns of the groundwater level and associated land subsidence in future. First, according to the regional hydrogeology, the simulation area was defined with an area of 10.6×103 km2, which was divided into six aquifer units. A coupled groundwater and land subsidence numerical model was built by using Modflow2005 and the land subsidence simulation module SUB(subsidence and aquifer-system compaction), in which the groundwater flow was modeled as three-dimensional unsteady flow and the land subsidence simulation was based on one-dimensional consolidation theory. The model was then calibrated by using the groundwater level contour lines, hydrographs, and land subsidence hydrographs over the period of 1998–2008. In addition, groundwater balance analysis of the simulation period indicated that under multi-year groundwater withdrawal condition the cross-flow recharge, compression release, and lateral boundary inflow contributed 44.43%, 32.14%, and 21.88% to the deep aquifer recharge, respectively. Finally, the model was applied to predict the changing patterns of the groundwater levels and the associated variations in land subsidence under the control of groundwater exploitation after implementation of the south-to-north water diversion project. The simulation results demonstrated that the groundwater level may gradually increase year by year with an decrease in the groundwater withdrawal; and the land in dominated land subsidence regions including the urban area, Dagang, Hangu, Jinghai, Wuqing, and Jinnan, may rebound at an average rate of 2–3 mm/a, and the land subsidence rate in the other regions may decrease. | Yali Cui Chen Su Jingli Shao Yabin Wang Xiaoyuan Cao | 2014 | Journal of Earth Science2014，25，3： | 2 |
| 9 | Phenolic compounds and antioxidant properties of different grape cultivars grown in China显示文摘 | Changmou Xu Yali Zhang Lei Cao Jiang Lu | 2009 | Food Chemistry2009，，4： | 2 |
| 10 | Placenta-derived IL-32β activates neutrophils to promote preeclampsia development显示文摘Immune activation at the maternal-fetal interface is a main pathogenic factor of preeclampsia(PE).Neutrophils(PMNs)are activated in PE patients,but the mechanism and consequences of PMN activation need to be further explored.Here,we demonstrated that interleukin-32(IL-32)expression was significantly upregulated in syncytiotrophoblasts(STBs)and that IL-32β was the major isoform with increased expression in the placenta of severe PE(sPE)patients.Furthermore,the level of IL-32 expression in the placenta was correlated with its level in the serum of sPE patients,indicating that IL-32 in the serum is derived mainly from the placenta.Then,in vitro experiments showed that IL-32β could highly activate PMNs and that these IL-32β-activated PMNs were better able to adhere to endothelial cells(HUVECs)and enhance the expression of vascular cell adhesion molecule-1(VCAM-1)and intercellular cell adhesion molecule-1(ICAM-1)in HUVECs,which could be reversed by preincubation with the NADPH oxidase inhibitor VAS 2870.In addition,we showed that IL-32β mainly activated PMNs by binding to proteinase 3.Finally,IL-32β administration induced a PE-like phenotype in a pregnant mouse model.This study provides evidence of the involvement of IL-32β in the pathogenesis of PE. | Dan Liu Qiang Li Hailin Ding Guangfeng Zhao Zhiyin Wang Chenrui Cao Yimin Dai Mingming Zheng Xiangyu Zhu Qianwen Wu Ya Wang Honglei Duan Huirong Tang Xianyan Lu Yayi Hou Yali Hu | 2021 | Cellular & Molecular Immunology2021，18，4： | 2 |
| 11 | Facile synthesis of Bi2S3 hierarchical nanostructure with enhanced photocatalytic activity显示文摘 | Chen Fengjuan Cao Yali Jia Dianzen | 2013 | Journal of Colloid and Interface Science2013，404，： | 1 |
| 12 | Phenolic compounds and antioxidant properties of different grape cultivars grown in China显示文摘 | Changmou Xu Yali Zhang Lei Cao | 2009 | Food Chemistry2009，199，4： | 1 |
| 13 | RNA-binding protein ZCCHC4 promotes human cancer chemoresistance by disrupting DNA-damage-induced apoptosis显示文摘RNA-binding proteins(RBPs)play important roles in cancer development and treatment.However,the tumor-promoting RBPs and their partners,which may potentially serve as the cancer therapeutic targets,need to be further identified.Here,we report that zinc finger CCHC domain-containing protein 4(ZCCHC4)is of aberrantly high expression in multiple human cancer tissues and is associated with poor prognosis and chemoresistance in patients of hepatocellular carcinoma(HCC),pancreatic cancer and colon cancer.ZCCHC4 promotes chemoresistance of HCC cells to DNA-damage agent(DDA)both in vitro and in vivo.HCC cell deficiency of ZCCHC4 reduces tumor growth in vivo and intratumoral interference of ZCCHC4 expression obviously enhances the DDAinduced antitumor effect.Mechanistically,ZCCHC4 inhibits DNA-damage-induced apoptosis in HCC cells by interacting with a new long noncoding RNA(lncRNA)AL133467.2 to hamper its pro-apoptotic function.Also,ZCCHC4 blocks the interaction between AL133467.2 andγH2AX upon DDA treatment to inhibit apoptotic signaling and promote chemoresistance to DDAs.Knockout of ZCCHC4 promotes AL133467.2 andγH2AX interaction for enhancing chemosensitivity in HCC cells.Together,our study identifies ZCCHC4 as a new predictor of cancer poor prognosis and a potential target for improving chemotherapy effects,providing mechanistic insights to the roles of RBPs and their partners in cancer progression and chemoresistance. | Ha Zhu Kun Chen Yali Chen Juan Liu Xiaomin Zhang Yumei Zhou Qiuyan Liu Bingjing Wang Taoyong Chen Xuetao Cao | 2022 | Signal Transduction and Targeted Therapy2022，7，8： | 1 |
| 14 | 显示文摘 | Cao Yali Hu Pengfei Pan Weiyu | 2008 | Sensors and Actuators B: Chemical2008，134，： | 1 |
| 15 | Methanal and xylene sensors based on ZnO nanoparticles and nanorods prepared by room-temperature solid-state chemical reaction显示文摘 | Yali Cao Pengfei Hu Weiyu Pan Yudai Huang Dianzeng Jia | 2008 | Sensors & Actuators: B. Chemical2008，，2： | 1 |
| 16 | Methanal and xylene sensors based on ZnO nanoparticles and nanorods prepared by room-temperature solid-state chemical reaction显示文摘 | Yali Cao Pengfei Hu Weiyu Pan Yudai Huang Dianzeng Jia | 2008 | Chemical2008，，2： | 1 |
| 17 | Experimental e- valuation of decrease in the activities of polyphosphate/glyco- gen-accumulating organisms due to cell death and activity de- cay in activated sludge显示文摘 | HAO Xiaodi WANG Qilin CAO Yali | 2010 | Biotechnology and Bioengineering2010，106，3： | 1 |
| 18 | 基于MFD及实时路况的城市道路机动车排放计算方法显示文摘本文提出了基于交通流宏观基本图(MFD)以及实时路况数据的城市道路机动车排放计算方法,并以环境保护部发布的指导方法为参照,对所述方法进行了对比验证。以2015年3月北京市五环路高速,国道京福路,省道京周路的氮氧化物排放为例,两种方法计算结果平均偏差分别为?27.7%,?12.9%,?12.0%。因此,基于MFD及实时路况数据对交通流量及机动车排放的估算,可以较好地反映道路机动车的运行情况及排放特征,在构建应用于街区尺度模型的排放清单,城市区域道路机动车排放的时空分布特征等方面具有非常好的应用潜力。 | WANG Kun TONG Yali CAO Tianhui WANG Chenlong WANG Renjie GAO Jiajia LIU Yuan | 2020 | Atmospheric and Oceanic Science Letters2020，13，2： | 1 |
| 19 | Diabetes and hypertension have become leading causes of CKD in Chinese elderly patients: a comparison between 1990–1991 and 2009–2010显示文摘 | Yali Cao Wenge Li Guannan Yang Yutian Liu Xin Li | 2012 | International Urology and Nephrology2012，，4： | 1 |
| 20 | Clinical application of massively parallel sequencing‐based prenatal noninvasive fetal trisomy test for trisomies 21 and 18 in 11 105 pregnancies with mixed risk factors显示文摘 | Shan Dan Wei Wang Jinghui Ren Yali Li Hua Hu Zhengfeng Xu Tze Kin Lau Jianhong Xie Weihua Zhao Hefeng Huang Jiansheng Xie Luming Sun Xiaohong Zhang Weipeng Wang Shixiu Liao Rong Qiang Jiangxia Cao Qiufang Zhang Yulin Zhou Haiyan Zhu Mei Zhong Yi Guo Linhu | 2012 | Prenat Diagn2012，，13： | 1 |
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