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| 1 | Notch signaling pathway:architecture,disease,and therapeutics显示文摘The NOTCH gene was identified approximately 110 years ago.Classical studies have revealed that NOTCH signaling is an evolutionarily conserved pathway.NOTCH receptors undergo three cleavages and translocate into the nucleus to regulate the transcription of target genes.NOTCH signaling deeply participates in the development and homeostasis of multiple tissues and organs,the aberration of which results in cancerous and noncancerous diseases.However,recent studies indicate that the outcomes of NOTCH signaling are changeable and highly dependent on context.In terms of cancers,NOTCH signaling can both promote and inhibit tumor development in various types of cancer.The overall performance of NOTCH-targeted therapies in clinical trials has failed to meet expectations.Additionally,NOTCH mutation has been proposed as a predictive biomarker for immune checkpoint blockade therapy in many cancers.Collectively,the NOTCH pathway needs to be integrally assessed with new perspectives to inspire discoveries and applications.In this review,we focus on both classical and the latest findings related to NOTCH signaling to illustrate the history,architecture,regulatory mechanisms,contributions to physiological development,related diseases,and therapeutic applications of the NOTCH pathway.The contributions of NOTCH signaling to the tumor immune microenvironment and cancer immunotherapy are also highlighted.We hope this review will help not only beginners but also experts to systematically and thoroughly understand the NOTCH signaling pathway. | Binghan Zhou Wanling Lin Yaling Long Yunkai Yang Huan Zhang Kongming Wu Qian Chu | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 14 |
| 2 | Chromosome analysis of esophageal squamous cell carcinoma cell line KYSE 410-4 by repetitive multicolor fluorescence in situ hybridization显示文摘Chromosome aberrations are distinctive features of human malignant tumors. Analysis of chromosomal changes can illuminate the molecular mechanisms underlying the development and progression of cancer. To establish the technique of multicolor fluorescence in situ hybridization (M-FISH) for identifying chromosome aberrations in esophageal carcinoma cell line KYSE 410-4, four pools of 6-color whole-chromosome painting probes have been designed and hybridized on the same metaphase spread by four rounds of repetitive FISH. Repetitive 6-color M-FISH was successfully established and the cytogenetic abnormalities in KYSE 410-4 cells were characterized. Chromosome gains occurred at 2q, 3, 8, 17p, and X. An isochromosome 3q was visualized in the cell line, which might be one intermedi- ate mechanism leading to 3p losses and/or 3q gains. Furthermore, 16 structural arrangements were detected, including four derivative chromosomes. The rearrangement of the centromeric regions accounted for approximately 44% of all rearrangements. The results added a more complete and accurate information of the genetic alterations to the classical cytogenetic description of KYSE 410-4 and provided a detailed cytogenetic background data for appropriate use of the cell line. The established 6-color M-FISH was useful for analyzing chro- mosomes in the whole genome of human tumors. | Yiling Yang Jiayou Chu Yupeng Wu Manli Luo Xin Xu Yaling Han Yan Cai Qimin Zhan Mingrong Wang | 2008 | Journal of Genetics and Genomics2008，35，1： | 6 |
| 3 | A viral protein orchestrates rice ethylene signaling to coordinate viral infection and insect vector-mediated transmission显示文摘Arthropod-borne viruses cause serious threats to human health and global agriculture by rapidly spreading via insect vectors. Southern rice black-streaked dwarf virus (SRBSDV) is the most damaging rice-infecting virus that is frequently transmitted by planthoppers. However, the molecular mechanisms underlying its propagation in the host plants and epidemics in the field are largely unknown. Here, we showed that the SRBSDV-encoded P6 protein is a key effector that regulates rice ethylene signaling to coordinate viral infection and transmission. In early SRBSDV infection, P6 interacts with OsRTH2 in the cytoplasm to activate ethylene signaling and enhance SRBSDV proliferation;this also repels the insect vector to reduce infestation. In late infection, P6 enters the nucleus, where it interacts with OsEIL2, a key transcription factor of ethylene signaling. The P6-OsEIL2 interaction suppresses ethylene signaling by preventing the dimerization of OsEIL2, thereby facilitating viral transmission by attracting the insect vector. Collectively, these findings reveal a novel molecular mechanism by which an arbovirus modulates the host defense system to promote viral infection and transmission. | Yaling Zhao Xue Cao Weihua Zhong Shunkang Zhou Zhanbiao Li Hong An Xiahua Liu Ruifeng Wu Surakshya Bohora Yan Wu Zhenyi Liang Jiahao Chen Xin Yang Guohui Zhou Tong Zhang | 2022 | Molecular Plant2022，15，4： | 4 |
| 4 | Research progress in electrospinning engineering for all-solid-state electrolytes of lithium metal batteries显示文摘Owing to safety issue and low energy density of liquid lithium-ion batteries(LIBs),all-solid-state lithium metal batteries(ASLMBs)with unique all-solid-state electrolytes(SEs)have attracted wide attentions.This arises mainly from the advantages of the SEs in the suppression of lithium dendrite growth,long cycle life,and broad working temperature range,showing huge potential applications in electronic devices,electric vehicles,smart grids,and biomedical devices.However,SEs suffer from low lithiumion conductivity and low mechanical integrity,slowing down the development of practical ASLMBs.Nanostructure engineering is of great efficiency in tuning the structure and composition of the SEs with improved lithium-ion conductivity and mechanical integrity.Among various available technologies for nanostructure engineering,electrospinning is a promising technique because of its simple operation,cost-effectiveness,and efficient integration with different components.In this review,we will first give a simple description of the electrospinning process.Then,the use of electrospinning technique in the synthesis of various SEs is summarized,for example,organic nanofibrous matrix,organic/inorganic nanofibrous matrix,and inorganic nanofibrous matrix combined with other components.The current development of the advanced architectures of SEs through electrospinning technology is also presented to provide references and ideas for designing high-performance ASLMBs.Finally,an outlook and further challenges in the preparation of advanced SEs for ASLMBs through electrospinning engineering are given. | Manxi Wang Yaling Wu Min Qiu Xuan Li Chuanping Li Ruiling Li Jiabo He Ganggang Lin Qingrong Qian Zhenhai Wen Xiaoyan Li Ziqiang Wang Qi Chen Qinghua Chen Jinhyuk Lee Yiu-Wing Mai Yuming Chen | 2021 | Journal of Energy Chemistry2021，30，10： | 4 |
| 5 | A botanical medicine dragon’s blood exhibited clinical antithrombosis efficacy similar to low molecular weight heparin显示文摘Deep vein thrombosis(DVT)is a common complication following traumatic fracture with a 0.5%–1%annual incidence.Low molecular weight heparin(LMWH)is the most commonly used anticoagulation drug for DVT prevention,but treatment with LMWH is invasive.Our aim is to compare the antithrombotic effect of dragon’s blood,an oral botanical anticoagulant medicine approved by the Chinese FDA,with LMWH in patients undergoing hip fracture surgery and to explore the molecular mechanisms of anticoagulation treatment.Our study recruited patients and divided them into LMWH and dragon’s blood treatment group.Coagulation index tests,Doppler ultrasound and mRNA sequencing were performed before and after anticoagulation therapy.There was no significant difference in postoperative DVT incidence between the two groups(23.1%versus 15.4%,P=0.694).D-dimer(D-D)and fibrinogen degradation product(FDP)showed significant reductions in both groups after anticoagulation treatments.We identified SLC4A1,PROS1,PRKAR2B and seven other genes as being differentially expressed during anticoagulation therapy in both groups.Genes correlated with coagulation indexes were also identified.Dragon’s blood and LMWH showed similar effects on DVT and produced similar gene expression changes in patients undergoing hip fracture surgery,indicating that dragon’s blood is a more convenient antithrombosis medicine(oral)than LMWH(hypodermic injection). | Jiangbin Liang Song Mei Xiangyu Qiao Wei Pan Yan Zhao Shaohui Shi Yaling Zhai Haizhao Wen Guoping Wu Chengyu Jiang | 2021 | Science China(Life Sciences)2021，64，10： | 4 |
| 6 | Spatial and Temporal Variations in Earthquake Stress Drops between the 2008 Wenchuan and 2013 Lushan Earthquakes显示文摘As a case study of spatial and temporal variations in earthquake stress drops between the 2008 Ms 8.0 Wenchuan and 2013 Ms 7.0 Lushan earthquakes,we computed 1828 stress-drop values for earthquakes with magnitudes 1.7≤ML≤5.0 during an eight-year time span before and after major earthquakes.We divide the study area into three subregions(the southern segment of the Longmen Shan fault zone;the southwestern junction of the Longmen Shan and Sichuan Basin;and the southwestern margin of the Sichuan Basin)and calculate individual event stress drops in each.The results show that regions of alternating high and low stress drop are found on either side of the southwestern segment of the Longmen Shan fault zone.During the two-year period after the 2008 Ms 8.0 Wenchuan earthquake,the stress state of the southern Longmen Shan fault shows no significant change.A marked increase in stress level appears about 18 months before the 2013 Ms 7.0 Lushan earthquake near the Lushan hypocenter zone.Two months after the Ms 7.0 event,the stress drops suddenly attenuate,with significantly less seismic energy release per event.We find that changes in the patterns of high and low stress drop values are consistent with the process of stress accumulation or transfer from the pre-mainshock to postmainshock periods.The results indicate that major earthquakes are the dominant cause of temporal and spatial evolution in stress levels.Stress drop variations show obvious temporal and spatial patterns that may suggests subtle changes in the character of stress fields on faults and spatial variations related to local intense compression and tectonic effects. | WU Weiwei LONG Feng LIANG Mingjian WEI Yaling SUN Wei CHEN Xuefen ZHAO Jing | 2020 | Acta Geologica Sinica(English Edition)2020，94，5： | 4 |
| 7 | The genome of Magnolia biondii Pamp. provides insights into the evolution of Magnoliales and biosynthesis of terpenoids显示文摘Magnolia biondii Pamp.(Magnoliaceae,magnoliids)is a phylogenetically,economically,and medicinally important ornamental tree species widely grown and cultivated in the north-temperate regions of China.Determining the genome sequence of M.biondii would help resolve the phylogenetic uncertainty of magnoliids and improve the understanding of individual trait evolution within the Magnolia genus.We assembled a chromosome-level reference genome of M.biondii using~67,~175,and~154Gb of raw DNA sequences generated via Pacific Biosciences single-molecule real-time sequencing,10X Genomics Chromium,and Hi-C scaffolding strategies,respectively.The final genome assembly was~2.22Gb,with a contig N50 value of 269.11 kb and a BUSCO complete gene percentage of 91.90%.Approximately 89.17%of the genome was organized into 19 chromosomes,resulting in a scaffold N50 of 92.86Mb.The genome contained 47,547 protein-coding genes,accounting for 23.47%of the genome length,whereas 66.48%of the genome length consisted of repetitive elements.We confirmed a WGD event that occurred very close to the time of the split between the Magnoliales and Laurales.Functional enrichment of the Magnolia-specific and expanded gene families highlighted genes involved in the biosynthesis of secondary metabolites,plant–pathogen interactions,and responses to stimuli,which may improve the ecological fitness and biological adaptability of the lineage.Phylogenomic analyses revealed a sister relationship of magnoliids and Chloranthaceae,which are sister to a clade comprising monocots and eudicots.The genome sequence of M.biondii could lead to trait improvement,germplasm conservation,and evolutionary studies on the rapid radiation of early angiosperms. | Shanshan Dong Min Liu Yang Liu Fei Chen Ting Yang Lu Chen Xingtan Zhang Xing Guo Dongming Fang Linzhou Li Tian Deng Zhangxiu Yao Xiaoan Lang Yiqing Gong Ernest Wu Yaling Wang Yamei Shen Xun Gong Huan Liu Shouzhou Zhang | 2021 | Horticulture Research2021，8，1： | 4 |
| 8 | Research Progress on Photocatalytic Reduction of the Nitrate Radical显示文摘Due to a large number of application of the nitrogen fertilizer,unreasonable treatments of the animal wastes,domestic sewage and industrial sewage including nitrogen,and garbage stacking in recent years,the concentration of NO 3 that was toxic to humans in worldwide ground water presented rise trend at different degrees.Photocatalytic removal technology of the nitrogen had many advantages and was widely valued.Cost was low,and there was no secondary pollution.Reaction condition was mild,and reaction time was short.The photocatalytic reduction research of nitrate at home and abroad was reviewed in detail,including photocatalyst,scavenger and reaction mechanism.In particular,perspectives for photocatalytic reduction of the nitrate were detailedly analyzed. | Yingchun Miao Guang Chen Gang Wang Yaling Gao Shipeng Wu | 2013 | Meteorological and Environmental Research2013，4，1： | 3 |
| 9 | Electrospun carbon nanofibers for lithium metal anodes:Progress and perspectives显示文摘Li metal anodes(LMAs)has attracted extensive research interest because of its extremely high theoretical capacity(3860 m Ah/g)at low redox potential(-3.04 V vs.standard hydrogen electrode).However,the extremely high chemical reactivity and the intrinsic“hostless”nature of LMAs bring about serious dendritic growth and dramatic volume change during the plating/strapping process,thus resulting in poor Coulombic efficiency,short lifespan,and severe safety concerns.Of various strategies,the construction of three-dimensional carbonaceous scaffolds for LMAs can substantially reduce the local current density,inhibit Li dendrite growth,and accommodate volume variation.Electrospinning is a simple yet effective strategy to fabricate carbon nanofibers(CNFs),which have been regarded as promising skeletons for LMAs,owing to their large surface areas,good electrical conductivity,and high porosity.In this Mini Review,we briefly introduce the fabrication of CNFs using electrospinning and the modification of CNFs.We highlight the recent advances in electrospun CNF skeletons for LMAs,including pure CNF and CNF-based composite scaffolds.Finally,we discuss the remaining challenges of electrospun CNF scaffolds for LMAs and provide possible solutions to push forward the advancement in this field. | Hongyang Chen Manxian Li Chuanping Li Xuan Li Yaling Wu Xiaochuan Chen Junxiong Wu Xiaoyan Li Yuming Chen | 2022 | Chinese Chemical Letters2022，33，1： | 3 |
| 10 | The Intronic cis Element SE1 Recruits trans-Acting Repressor Complexes to Repress the Expression of ELONGATED UPPERMOST INTERNODE1 in Rice显示文摘 | Yongyao Xie Yaling Zhang Jingluan Han Jikai Luo Gousi Li Jianle Huang Haibin WU Qingwei Tian Qinlong Zhu Yuanling Chen Yoji Kawano Yao-Guang Liu Letian Chen | 2018 | Molecular Plant2018，11，5： | 3 |
| 11 | Intermolecular recognition revealed by the complex structure of human CLOCK-BMAL1 basic helix-loop-helix domains with E-box DNA显示文摘钟(生理节奏的运动输出周期不行了) 并且 BMAL1 (大脑和肌肉象 ARNT 一样 1 ) 两个都是在哺乳动物的生理节奏的核心循环的抄写因素。最近出版的老鼠 CLOCK-BMAL1 bHLH (基本 helix-loop-helix ) 舞步(period-ARNT-single-minded ) 建筑群结构为 heterodimer 形成,而是机制仍然是的 protein-DNA 识别的结构的细节使机制清楚些逃犯。这里,我们阐明了人的 CLOCK-BMAL1 bHLH 领域的水晶结构跳了到正规电子盒子 DNA。我们证明钟和 BMAL1 bHLH 领域能互相被选择,并且结合氢的网络调停他们的电子盒子识别。我们识别了在 BMAL1 Ile80 和 flanking 胸腺嘧啶核苷酸之间的恐水病的接触,建议 CLOCK-BMAL1 实际上读 7-bp DNA 并且不以前相信的 6-bp DNA。为了发现潜在的不在经典中的电子盒子那,能被 CLOCK-BMAL1 认出,我们在电子盒子上构造了系统的单个核苷酸的变化并且测量了他们的相关亲密关系。我们与高亲密关系, AACGTGA 和 CATGTGA 定义二个不在经典中的电子盒子模式,在里面它 flanking A7-T7′基础对为识别是不可缺少的。这些结果将帮助我们在 vivo 识别功能的 CLOCK-BMAL1-binding 地点并且寻找控制钟的基因。而且,我们在 bHLH 区域估计了潜在的 phosphorylation 地点的禁止的角色。我们发现 BMAL1 Ser78 上的 phospho-mimicking 变化能高效地堵住有约束力的 DNA 以及在房间废除正常生理节奏的摆动。我们建议 BMAL1 Ser78 应该是调停的关键残余输入调整信号的 transcriptional 抑制让外部暗示乘火车由 kinase 的生理节奏的钟串联。 | Zixi Wang Yaling Wu Lanfen Li Xiao-Dong Su | 2013 | Cell Research2013，23，2： | 3 |
| 12 | A urinary proteomic landscape of COVID-19 progression identifies signaling pathways and therapeutic options显示文摘Signaling pathway alterations in COVID-19 of living humans as well as therapeutic targets of the host proteins are not clear.We analyzed 317 urine proteomes,including 86 COVID-19,55 pneumonia and 176 healthy controls,and identified specific RNA virus detector protein DDX58/RIG-I only in COVID-19 samples.Comparison of the COVID-19 urinary proteomes with controls revealed major pathway alterations in immunity,metabolism and protein localization.Biomarkers that may stratify severe symptoms from moderate ones suggested that macrophage induced inflammation and thrombolysis may play a critical role in worsening the disease.Hyper activation of the TCA cycle is evident and a macrophage enriched enzyme CLYBL is up regulated in COVID-19 patients.As CLYBL converts the immune modulatory TCA cycle metabolite itaconate through the citramalyl-CoA intermediate to acetyl-CoA,an increase in CLYBL may lead to the depletion of itaconate,limiting its anti-inflammatory function.These observations suggest that supplementation of itaconate and inhibition of CLYBL are possible therapeutic options for treating COVID-19,opening an avenue of modulating host defense as a means of combating SARS-CoV-2 viruses. | Yuntao Liu Lan Song Nairen Zheng Jinwen Shi Hongxing Wu Xing Yang Nianci Xue Xing Chen Yimin Li Changqing Sun Cha Chen Lijuan Tang Xiaotian Ni Yi Wang Yaling Shi Jianwen Guo Guangshun Wang Zhongde Zhang Jun Qin | 2022 | Science China(Life Sciences)2022，65，9： | 1 |
| 13 | Antithrombotic Management of Atrial Fibrillation Patients Presenting with Coronary Artery Disease:A Consensus Document of the Chinese Society of Cardiology显示文摘The coexistence of coronary artery disease(CAD)and atrial fibrillation(AF)is common in clinical practice.Patients with CAD require antiplatelet therapy to reduce the occurrence of myocardial ischemic events.However,patients with AF at high risk of thromboembolism require oral anticoagulants to reduce the occurrence of thromboembolic events such as stroke.In cases where CAD coexists with AF,the combined use of antiplatelet and anticoagulation therapy can effectively reduce the risk of ischemic and thromboembolic events but increase the risk of bleeding at the same time.The optimal antithrombotic regimen in patients with both CAD and AF has been controversial in clinical practice.In recent years,the expert consensuses on antithrombotic therapy in patients with AF presenting with acute coronary syndrome and/or undergoing percutaneous coronary intervention have been successively released in Europe and North America,and have been updated in a timely manner.In contrast,the guidelines on antithrombotic therapies in China are lacking.Based on published clinical evidence,this consensus incorporated relevant international and Chinese guidelines,consensuses,and expert recommendations,and addressed the issues encountered in the clinical practice of antithrombotic therapy in patients with AF and different types of CAD.The current guideline is of great significance to guide treatment in patients with both CAD and AF in China. | Chinese Society of Cardiology of Chinese Medical Association Editorial Board of Chinese Journal of Cardiology Zuyi Yuan Shulin Wu Yaling Han Peng Qu Shaowen Liu Changsheng Ma Yumei Xue Xinjun Lei | 2021 | Cardiology Discovery2021，1，1： | 1 |
| 14 | Antifreeze glycoproteins: relationship between molecular weight, thermal hysteresis and the inhibition of leakage from liposomes during thermotropic phase transition 显示文摘 | Yaling Wu Joseph Banoub | 2001 | Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology2001，128，2： | 1 |
| 15 | Report on Screening Test of Dazhou Superior Ramie Germplasm Resources显示文摘[Objectives]To promote the development of the ramie industry in Dazhou City of Sichuan Province and provide a material basis for the breeding of new ramie varieties.[Methods]The Institute of Bast Fiber Crops of Dazhou Academy of Agricultural Sciences performed a screening test of excellent ramie germplasm resources from 2017 to 2019 to compare the growth,resistance,raw fiber yield and fiber fineness of the experimental materials.[Results]All the experimental materials showed strong growth potential,drought resistance and disease resistance.There were 8 kinds of resources with a fiber fineness greater than 2000 m/g,of which 3 kinds of resource materials had a fiber fineness greater than 2300 m/g;12 kinds of resources has the raw fiber yield exceeding the control and 10 kinds of resources had the raw fiber yield≥2000 kg/ha;3 kinds of resources met the requirements of the high-yield and high-quality indicators(fiber fineness exceeding 2000 m/g and raw fiber yield≥2000 kg/ha),they were BD0718,BD1614 and BYL2.[Conclusions]These high-quality ramie resources can provide a rich resource base for the breeding of new ramie varieties. | Yaling LI Zhonggang CUI Yun GOU Zhaoxia TANG Yan YANG Wenmei WU Zhonghua ZHANG | 2020 | Asian Agricultural Research2020，12，6： | 1 |
| 16 | Isolation, purification and structural investigation of a water-soluble polysaccharide from Solarium lyratum Thunb显示文摘 | WU Yaling PAN Yuanjiang SUN Cuirong | 2005 | International Journal of Biological Macromolecules2005，36，4： | 1 |
| 17 | Plasma biomarkers and plaque strain predict long-term cardiovascular events in patients with acute coronary syndrome显示文摘To test whether circulating and intracoronary biomarkers and coronary plaque strain have additive values to Global Registry of Acute Coronary Events(GRACE) score for predicting long-term cardiovascular events in ACS patients. One hundred ACS patients were enrolled and the GRACE score and plasma levels and intracoronary gradients of a number of biomarkers were measured. Coronary plaque burden and morphology in non-critical stenotic plaques were determined by intravascular ultrasound(IVUS) technique, and the maximal shear strain(SSmax) and maximal area strain(ASmax) were determined by intravascular ultrasound elastography(IVUSE) technique. Patients were followed for cardiovascular events and the predictive values of clinical characteristics, plasma biomarkers and plaque parameters were compared with GRACE score, and the incremental values of these measurements to the GRACE score were assessed. GRACE score, plasma biomarkers and plaque strain were independent predictors of cardiovascular events. Combination of GRACE score, plasma biomarkers and plaque strains significantly improved the predictive value of the GRACE score alone with the receiver-operating characteristic area increased from0.457 to 0.667(P=0.014). The combination of circulating and intracoronary biomarkers, plaque strain and GRACE score provides a better predictive tool than GRACE score alone in patients with ACS. | Mingjun Xu Xiaobo Hu Lin Wang Wei Zhang Lindi Wu Jifu Li Yuguo Chen Pengfei Zhang Haijun Su Yaling Han Cheng Zhang Mei Zhang Yun Zhang | 2020 | Science China(Life Sciences)2020，63，2： | 1 |
| 18 | The kinetic study of light alkene syntheses by CO_(2) hydrogenation over Fe-Ni catalysts显示文摘A kinetics model of CO_(2) hydrogenation over iron-nickel catalysts was developed based on the detailed mechanism of alkenes re-adsorption and secondary reaction.The corresponding kinetical experiments are conducted in a continuous fixed bed reactor.The effect of reaction conditions on catalyst performance was analyzed according to the results of orthogonal experiments.The results of the experiments show that more methane in products can be obtained with iron-nickel catalysts,the trend of which is consistent with the thermodynamic analysis.However,the content of alkenes in products is equivalent with that of alkanes.This shows that the reaction is controlled by kinetics.In all,the results of the experiments also substantiate that the model can give a good representation of the reaction mechanism of CO_(2) hydrogenation over iron-nickel catalysts.The parameters of this model give a better explanation for the question why the iron-nickel catalysts have a higher selectivity toward alkenes compared with other iron-based catalysts. | Yaling ZHAO Li WANG Xiwei HAO Jiazhou WU | 2010 | Frontiers of Chemical Science and Engineering2010，4，2： | 1 |
| 19 | Muscle-inspired soft robots based on bilateral dielectric elastomer actuators显示文摘Muscle groups perform their functions in the human body via bilateral muscle actuation,which brings bionic inspiration to artificial robot design.Building soft robotic systems with artificial muscles and multiple control dimensions could be an effective means to develop highly controllable soft robots.Here,we report a bilateral actuator with a bilateral deformation function similar to that of a muscle group that can be used for soft robots.To construct this bilateral actuator,a low-cost VHB 4910 dielectric elastomer was selected as the artificial muscle,and polymer films manufactured with specific shapes served as the actuator frame.By end-to-end connecting these bilateral actuators,a gear-shaped 3D soft robot with diverse motion capabilities could be developed,benefiting from adjustable actuation combinations.Lying on the ground with all feet on the ground,a crawling soft robot with dexterous movement along multiple directions was realized.Moreover,the directional steering was instantaneous and efficient.With two feet standing on the ground,it also acted as a rolling soft robot that can achieve bidirectional rolling motion and climbing motion on a 2°slope.Finally,inspired by the orbicularis oris muscle in the mouth,a mouthlike soft robot that could bite and grab objects 5.3 times of its body weight was demonstrated.The bidirectional function of a single actuator and the various combination modes among multiple actuators together allow the soft robots to exhibit diverse functionalities and flexibility,which provides a very valuable reference for the design of highly controllable soft robots. | Yale Yang Dengfeng Li Yanhua Sun Mengge Wu Jingyou Su Ying Li Xinge Yu Lu Li Junsheng Yu | 2023 | Microsystems & Nanoengineering2023，9，5： | 0 |
| 20 | Graphene: A promising candidate for charge regulation in high-performance lithium-ion batteries显示文摘The development of rechargeable lithium-ion batteries (LIBs) is being driven by the ever-increasing demand for high energy density and excellent rate performance. Charge transfer kinetics and polarization theory, considered as basic principles for charge regulation in the LIBs, indicate that the rapid transfer of both electrons and ions is vital to the electrochemical reaction process. Graphene, a promising candidate for charge regulation in high-performance LIBs, has received extensive investigations due to its excellent carrier mobility, large specific surface area and structure tunability, etc. Recent progresses on the structural design and interfacial modification of graphene to regulate the charge transport in LIBs have been summarized. Besides, the structure-performance relationships between the structure of the graphene and its dedicated applications for LIBs have also been clarified in detail. Taking graphene as a typical example to explore the mechanism of charge regulation will outline ways to further understand and improve carbon-based nanomaterials towards the next generation of electrochemical energy storage devices. | Danping Sun Zhi Tan Xuzheng Tian Fei Ke Yale Wu Jin Zhang | 2021 | Nano Research2021，14，12： | 0 |
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