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| 1 | Clinical research linking Traditional Chinese Medicine constitution types with diseases:a literature review of 1639 observational studies显示文摘OBJECTIVE:To analyze clinical studies on correlations between Traditional Chinese Medicine(TCM)body constitution types and diseases published in the past 10 years,and to provide an evidence base to support the use of such correlations for health maintenance and disease prevention.METHODS:We searched five databases for the period April 2009 to December 2019:China National Knowledge Infrastructure Database,Wanfang Database,China Science and Technology Journal Database,PubMed and Embase.Three types of observational studies on correlation between constitution types and diseases were included:cross-sectional,case-control and cohort studies.Descriptive statistical methods were employed for data analysis.RESULTS:A total of 1639 clinical studies were identified:1452(88.59%)cross-sectional studies,115(7.02%)case-control studies and 72(4.39%)cohort studies covering 30 regions of China and five other countries(Malaysia,South Korea,Singapore,Thailand and France).The collection of studies comprised 19 disease categories and 333 different diseases.The 10 most commonly studied diseases were hypertension,diabetes,stroke,coronary atherosclerotic heart disease(CAHD),sleep disorders,neoplasm of the breast,dysmenorrhea,fatty liver disease,chronic viral hepatitis B and dyslipidemia.We found high distributions for each biased constitution type in different patient populations as follows:Qi-deficiency constitution in stroke,diabetes,chronic obstructive pulmonary disease,acquired immunodeficiency syndrome and hypertension;Yang-deficiency constitution in female infertility,osteoporosis,irritable bowel syndrome,gonarthrosis and dysmenorrhea;Yin-deficiency constitution in hypertension,diabetes,constipation,female climacteric states and osteoporosis;phlegm-dampness constitution in hypertension,stroke,fatty liver disease,diabetes and metabolic syndrome;damp-heat constitution in acne,chronic gastritis,chronic viral hepatitis B,human papillomavirus infection and hyperuricemia;blood-stasis constitution in CAHD,endometriosis and stroke;Qi-stagnation constitution in hyperplasia and neoplasms of the breast,insomnia,depression and thyroid nodules;and inherited-special constitution in asthma and allergic rhinitis.CONCLUSION:Eight biased TCM constitutions were closely related to specific diseases,and could be used to guide individualized prevention and treatment.More rigorously designed studies are recommended to further verify the constitution-disease relationship. | Liang Xue Wang Qi Jiang Zeqiang Li Zhuqing Zhang Mengxing Yang Peiying Wang Xin Wang Yanqiu Qin Yuehua Li Tianxing Zhang Tianyi Wang Yi Sun Jianxiang Li Yusi Luo Hui Li Lingru | 2020 | Journal of Traditional Chinese Medicine2020，40，4： | 29 |
| 2 | DISCUSSING ON SOLID ABRASIVE LAPPING PATH显示文摘DISCUSSINGONSOLIDABRASIVELAPPINGPATHYangJiandong,WenXuehengChangchunInstituteofOpticsandFineMechanicsZhuYanqiu,WangLijiangJil... | Yang Jiandong ,Wen XuehengChangchun Institute of Optics and Fine MechanicsZhu Yanqiu, Wang Lijiang Jilin University of Technology | 1997 | Chinese Journal of Mechanical Engineering1997，10，2： | 11 |
| 3 | Effect of Cl^- on the Properties of the Passive Films Formed on 316L Stainless Steel in Acidic Solution显示文摘The corrosion behavior of 316L stainless steel(316L SS) has been investigated in solutions containing various concentrations of chloride ions by using potentiodynamic polarization, capacitance measurement and Motte Schottky relationship analysis(Me S). The result indicates that passive currents change slightly with the addition of chloride ions. The pitting potential(Epit) decreases linearly with log[Cl ]. Correspondingly, the point defect diffusion coefficient(Do) of the passive film increases linearly with increasing log[Cl ]. The results also indicate that the pitting corrosion of 316L SS follows the adsorption mechanism in NaCl solution. | Guozhe Meng Yuan Li Yawei Shao Tao Zhang Yanqiu Wang Fuhui Wang | 2014 | Journal of Materials Science & Technology2014，30，3： | 10 |
| 4 | Tribological properties of conductive lubricating greases显示文摘Three kinds of new conductive lubricating greases were prepared using lithium ionic liquids as the base oil and the polytetrafluoroethylene(PTFE)as the thickener.These lithium ionic liquids([Li(PEG)X])were obtained by blending lithium salts(LiBF4,LiPF6 and LiNTf2)with poly(ethylene glycol)(PEG)because lithium salts have an extremely high solubility in PEG.The conductivities and contact resistances of the prepared lubricating greases were investigated using the DDSJ‐308A conductivity meter and the reciprocating ball‐on‐disk UMT‐2MT sliding tester.In addition,their tribological properties were investigated in detail.Scanning electron microscopy and X‐ray photoelectron spectroscopy were employed to explore the friction mechanisms.The results suggest that the prepared lubricating greases have high conductivities and excellent tribological properties.The high conductivities are attributed to ion diffusion or migration of the lithium ionic liquids with an external electric field,and the excellent tribological properties depend on the formation of boundary protective films. | Xiaoqiang FAN Yanqiu XIA Liping WANG | 2014 | Friction2014，2，4： | 10 |
| 5 | Sintilimab versus docetaxel as second-line treatment in advanced or metastatic squamous non-small-cell lung cancer:an open-label,randomized controlled phase 3 trial(ORIENT-3)显示文摘Background:Treatment options for Chinese patients with locally advanced or metastatic squamous-cell non-small-cell lung cancer(sqNSCLC)after failure of first-line chemotherapy are limited.This study(ORIENT-3)aimed to evaluate the efficacy and safety of sintilimab versus docetaxel as second-line treatment in patients with locally advanced or metastatic sqNSCLC.Methods:ORIENT-3 was an open-label,multicenter,randomized controlled phase 3 trial that recruited patients with stage IIIB/IIIC/IV sqNSCLC after failure with first-line platinum-based chemotherapy.Patients were randomized in a 1:1 ratio to receive either 200 mg of sintilimab or 75 mg/m^(2) of docetaxel intravenously every 3 weeks,stratified by the Eastern Cooperative Oncology Group performance status.The primary endpoint was overall survival(OS)in the full analysis set(FAS).Secondary endpoints included progression-free survival(PFS),objective response rate(ORR),disease control rate(DCR),duration of response(DoR)and safety.Results:Between August 25,2017,and November 7,2018,290 patients were randomized.For FAS,10 patients fromthe docetaxel armwere excluded.Themedian OS was 11.79(n=145;95%confidence interval[CI],10.28-15.57)months with sintilimab versus 8.25(n=135;95%CI,6.47-9.82)months with docetaxel(hazard ratio[HR]:0.74;95%CI,0.56-0.96;P=0.025).Sintilimab treatment significantly prolonged PFS(median 4.30 vs.2.79 months;HR:0.52;95%CI,0.39-0.68;P<0.001)and showed higher ORR(25.50%vs.2.20%,P<0.001)and DCR(65.50%vs.37.80%,P<0.001)than the docetaxel arm.The median DoRwas 12.45(95%CI,4.86-25.33)months in the sintilimab arm and 4.14(95%CI,1.41-7.23)months in the docetaxel arm(P=0.045).Treatment-related adverse events of grade≥3were reported in 26(18.1%)patients in the sintilimab arm and 47(36.2%)patients in the docetaxel arm.Exploratory biomarker analysis showed potential predictive values of expression levels of two transcription factors,including OVOL2(HR:0.35;P<0.001)and CTCF(HR:3.50;P<0.001),for sintilimab treatment.Conclusions:Compared with docetaxel,sintilimab significantly improved the OS,PFS,and ORR of Chinese patients with previously treated locally advanced or metastatic sqNSCLC. | Yuankai Shi Lin Wu Xinmin Yu Puyuan Xing Yan Wang Jianying Zhou Airong Wang Jianhua Shi Yi Hu Ziping Wang Guangyu An Yong Fang Sanyuan Sun Caicun Zhou Changli Wang Feng Ye Xingya Li Junye Wang Mengzhao Wang Yunpeng Liu Yanqiu Zhao Ying Yuan Jifeng Feng Zhendong Chen Jindong Shi Tao Sun Gang Wu Yongqian Shu Qisen Guo Yi Zhang Yong Song Shucai Zhang Yuan Chen Wei Li Hongrui Niu Wenwei Hu Lijun Wang Jianan Huang Yang Zhang Ying Cheng Zhengdong Wu Bo Peng Jiya Sun Christoph Mancao Yanqi Wang Luyao Sun | 2022 | Cancer Communications2022，42，12： | 8 |
| 6 | Toripalimab plus chemotherapy as second-line treatment in previously EGFR-TKI treated patients with EGFR-mutant-advanced NSCLC:a multicenter phase-II trial显示文摘This multicenter phase-II trial aimed to investigate the efficacy,safety,and predictive biomarkers of toripalimab plus chemotherapy as second-line treatment in patients with EGFR-mutant-advanced NSCLC.Patients who failed from first-line EGFR-TKIs and did not harbor T790M mutation were enrolled.Toripalimab plus carboplatin and pemetrexed were administrated every three weeks for up to six cycles,followed by the maintenance of toripalimab and pemetrexed.The primary endpoint was objective-response rate(ORR).Integrated biomarker analysis of PD-L1 expression,tumor mutational burden(TMB),CD8+tumor-infiltrating lymphocyte(TIL)density,whole-exome,and transcriptome sequencing on tumor biopsies were also conducted.Forty patients were enrolled with an overall ORR of 50.0%and disease-control rate(DCR)of 87.5%.The median progression free survival(PFS)and overall survival were 7.0 and 23.5 months,respectively.The most common treatment-related adverse effects were leukopenia,neutropenia,anemia,ALT/AST elevation,and nausea.Biomarker analysis showed that none of PD-L1 expression,TMB level,and CD8+TIL density could serve as a predictive biomarker.Integrated analysis of whole-exome and transcriptome sequencing data revealed that patients with DSPP mutation had a decreased M2 macrophage infiltration and associated with longer PFS than those of wild type.Toripalimab plus chemotherapy showed a promising anti-tumor activity with acceptable safety profiles as the second-line setting in patients with EGFR-mutant NSCLC.DSPP mutation might serve as a potential biomarker for this combination.A phase-III trial to compare toripalimab versus placebo in combination with chemotherapy in this setting is ongoing(NCT03924050). | Tao Jiang Pingyang Wang Jie Zhang Yanqiu Zhao Jianying Zhou Yun Fan Yongqian Shu Xiaoqing Liu Helong Zhang Jianxing He Guanghui Gao Xiaoqian Mu Zhang Bao Yanjun Xu Renhua Guo Hong Wang Lin Deng Ningqiang Ma Yalei Zhang Hui Feng Sheng Yao Jiarui Wu Luonan Chen Caicun Zhou Shengxiang Ren | 2021 | Signal Transduction and Targeted Therapy2021，6，11： | 8 |
| 7 | Numerical investigation on freeze-drying of aqueous material frozen with pre-built pores显示文摘Freeze-drying of the initially porous frozen material with pre-built pores from liquid material was found experimentally to save drying time by over 30% with an initial saturation being 0.28 compared with the conventional operation with the initial saturation being 1, using mannitol as the solid material. In order to understand the mass and heat transfer phenomena of this novel process, a two-dimensional mathematical model of coupled mass and heat transfer was derived with reference to the cylindrical coordinate system. Three adsorption–desorption equilibrium relationships between the vapour pressure and saturation value namely, power-law, Redhead's style and Kelvin's style equation, were tested. Kelvin's style in exponential form of adsorption equilibrium relation gave an excellent agreement between the model prediction and experimental measurement when the equation parameter, γ, of 5000 was applied. Analyses of temperature and ice saturation profiles show that additional heat needs to be supplied to increase the sample temperature in order to promote the desorption process. Simulation also shows that there is a threshold initial porosity after which the drying time decreased with the increase in the initial porosity. Enhanced freeze-drying is expected to be achieved by simultaneously enhancing mass and heat transfer of the process. | Wei Wang Dapeng Hu Yanqiu Pan Guohua Chen | 2016 | Chinese Journal of Chemical Engineering2016，24，1： | 7 |
| 8 | Baicalin and rutin are major constituents in Shuanghuanglian injection involving anaphylactoid reaction显示文摘OBJECTIVE: To identify the constituents in Shuanghuanglian injection(SHLI) that correlate with anaphylactoid reaction.METHODS: Chemical fingerprints of 10 batches SHLI samples were determined by High Performance Liquid Chromatography(HPLC), and further investigated by similarity analysis. Combined with optical microscopy, both anaphylactoid experiments and confirmatory assay were displayed in Rat basophil leukemia cells(RBL-2H3) to obtain the histamine release inducing by SHLI. The content of histamine was tested by Enzyme-Linked Immuno Sorbent As-say method. Partial least squares regression(PLSR)method and HPLC-DAD-ESI-MSntechnology were conducted to analyze constituents in SHLI involving anaphylactoid reaction.RESULTS: The results of spectrum and effect relationships showed that the eight constituents were positively correlated with anaphylactoid reaction.Among which, nearly 90% of them were identified as baicalin and rutin with PLSR and HPLC-DAD-ESI-MSn. This result was in accordance with confirmatory assay on RBL-2H3 cells.CONCLUSION: Baicalin and rutin from SHLI were the main constituents involving anaphylactoid reaction. | Zhang Qi Cai Chengke Li Jian Wang Penglong Si Yinchu Ding Nan Gao Jing Zhang Yanqiu Ma Zhiqiang Lei Haimin Li Qiang | 2017 | Journal of Traditional Chinese Medicine2017，37，3： | 6 |
| 9 | A four-compartment model for the COVID-19 infection—implications on infection kinetics,control measures,and lockdown exit strategies显示文摘Objective:To analyse the impact and repercussions of the surge in healthcare demand in response to the COVID-19 pandemic,assess the potential effectiveness of various infection/disease control measures,and make projections on the best approach to exit from the current lockdown.Design:A four-compartment model was constructed for SARS-CoV-2 infection based on the Wuhan data and validated with data collected in Italy,the UK,and the US.The model captures the effectiveness of various disease suppression measures in three modifiable factors:(a)the per capita contact rate(β)that can be lowered by means of social distancing,(b)infection probability upon contacting infectious individuals that can be lowered by wearing facemasks,personal hygiene,etc.,and(c)the population of infectious individuals in contact with the susceptible population,which can be lowered by quarantine.The model was used to make projections on the best approach to exit from the current lockdown.Results:The model was applied to evaluate the epidemiological data and hospital burden in Italy,the UK,and the US.The control measures were identified as the key drivers for the observed epidemiological data through sensitivity analyses.Analysing the different lockdown exit strategies showed that a lockdown exit strategy with a combination of social separation/general facemask use may work,but this needs to be supported by intense monitoring whichwould allowre-introduction/tightening of the controlmeasures if the number of newinfected subjects increases again.Conclusions and relevance:Governments should act early in a swift and decisive manner for containment policies.Any lockdown exit will need to be monitored closely,with regards to the potential of lockdown reimplementation.This mathematical model provides a framework for major pandemics in the future. | Tianbing Wang Yanqiu Wu Johnson Yiu-Nam Lau Yingqi Yu Liyu Liu Jing Li Kang Zhang Weiwei Tong Baoguo Jiang | 2020 | Precision Clinical Medicine2020，3，2： | 5 |
| 10 | Effect of Microstructures on Corrosion Behavior of Nickel Coatings:(Ⅱ) Competitive Effect of Grain Size and Twins Density on Corrosion Behavior显示文摘Nanocrystalline nickel coatings with grain size of 50 nm were annealed in vacuum at 200°C and 400°C for 10 min.Their microstructures were investigated by transmission electron microscopy(TEM).And their corrosion behaviors were studied by means of polarization and electrochemical impedance spectroscopy(EIS).The results showed that their grain size grew up to about 60 nm(200°C)and 500 nm(400°C),respectively.The specimen annealed at 200°C possessed higher density of twins in compared with the counterparts of as-deposited and annealed at 400°C.The normal grain size effect on the corrosion behavior was not observed.However,it was found that the corrosion resistance of the coating linearly changed with the density of twins. | Guozhe Meng Yang Li Yawei Shao Tao Zhang Yanqiu Wang Fuhui Wang Xuequn Cheng Chaofang Dong Xiaogang Li | 2016 | Journal of Materials Science & Technology2016，32，5： | 5 |
| 11 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 12 | Role of Al_(18)B_4O_(33) Whisker in MAO Process of Mg Matrix Composite and Protective Properties of the Oxidation Coating显示文摘Selective growth of oxidation coating was observed on Mg matrix composite Al18B4O33w/AZ91(a composite with Al18B4O33 crystal whisker as reinforced phase) when this composite was treated by microarc oxidation (MAO) technique,and then the role of Al18B4O33 whisker in the process of MAO was analyzed.The protective properties of MAO coating also were investigated.Scanning electron microscopy(SEM) was used to characterize the existing state of Al18B4O33 whisker in MAO process and the microstructure of MAO coating.Corrosion resistance of the bare and coated composite was evaluated by immersion corrosion test and potentiodynamic polarizing test.Wear resistance of MAO coating was investigated by a ball-on-disc friction and wear tester.The results showed that sparking discharge did not occur on Al18B4O33 whisker and the whisker existed in the coating as a heterogeneous phase when MAO coating grew on the composite;then the whisker would be covered gradually with growing thick of the coating.Corrosion current density of the coated composite was decreased by 4 orders of magnitude compared with that of the uncoated composite; excellent corrosion resistance was closely related to the compact whisker-coating interface since Al18B4O33 whisker did not induce structural defects.The coating also exhibited high wear resistance and a slight adhesive wear tendency with bearing steel as its counterpart material. | Yanqiu Wang Xiaojun Wang Kun Wu Fuhui Wang | 2013 | Journal of Materials Science & Technology2013，29，3： | 5 |
| 13 | Protection of Li metal anode by surface-coating of PVDF thin film to enhance the cycling performance of Li batteries显示文摘Lithium metal, the ideal anode material for next-generation high-energy batteries, suffers from the severe safety problem of Li dendrites. Herein, we report a simple approach to effectively maintain the morphology of Li-metal anode and enhance the cycling performance of Li batteries by surface coating of a porous polyvinylidene fluoride (PVDF) thin film. In symmetrical cells testing, the cells with the Li@PVDF electrode display stable cycling performance more than 1300 h (650 cycles) at the current density of 0.5 mA/cm^2 with a stripping/plating capacity of 0.5 mAh/cm^2. The results with full cells employing Li@PVDF anode and LiFePO_4 cathode show a good cycling ability with a capacity retention of 80.0% after 500 cycles at 4 C and an excellent rate capability with a high capacity of 78.4 mAh/g even at a high rate of 10 C. | Zhenguang Gao Shaojian Zhang Zhigen Huang Yanqiu Lu Weiwei Wang Kai Wang Juntao Li Yao Zhou Ling Huang Shigang Sun | 2019 | Chinese Chemical Letters2019，30，2： | 5 |
| 14 | Multifunctional SiC@SiO_(2) Nanofiber Aerogel with Ultrabroadband Electromagnetic Wave Absorption显示文摘Traditional ceramic materials are generally brittle and not flexible with high production costs,which seriously hinders their practical applications.Multifunctional nanofiber ceramic aerogels are highly desirable for applications in extreme environments,however,the integration of multiple functions in their preparation is extremely challenging.To tackle these challenges,we fabricated a multifunctional SiC@SiO_(2) nanofiber aerogel(SiC@SiO_(2) NFA)with a threedimensional(3D)porous cross-linked structure through a simple chemical vapor deposition method and subsequent heat-treatment process.The as-prepared SiC@SiO_(2) NFA exhibits an ultralow density(~11 mg cm^(-3)),ultra-elastic,fatigue-resistant and refractory performance,high temperature thermal stability,thermal insulation properties,and significant strain-dependent piezoresistive sensing behavior.Furthermore,the SiC@SiO_(2) NFA shows a superior electromagnetic wave absorption performance with a minimum refection loss(RL_(min))value of-50.36 d B and a maximum effective absorption bandwidth(EAB_(max))of 8.6 GHz.The successful preparation of this multifunctional aerogel material provides a promising prospect for the design and fabrication of the cutting-edge ceramic materials. | Limeng Song Fan Zhang Yongqiang Chen Li Guan Yanqiu Zhu Mao Chen Hailong Wang Budi Riza Putra Rui Zhang Bingbing Fan | 2022 | Nano-Micro Letters2022，14，9： | 4 |
| 15 | Biting force and tongue muscle strength as useful indicators for eating and swallowing capability assessment among elderly patients显示文摘Weakened capability of eating and swallowing is common among elderly population,affecting negatively on their health and well-being.This work measured occlusal force and tongue muscle strength of elderly patients and then assessed whether correlations existed between oral physiological properties and the eating and swallowing capability.A total of 26 elderly patients with potential swallow disorder were recruited in this work.Participants’denture status and daily diet texture were determined by a pre-questionnaire analysis.Their swallowing capability was assessed and rated by water drinking test.Maximum tongue pressure,incisor occlusal force and hand gripping force were measured for each subject.It was observed that participating subjects have on average a significantly lower biting force and maximum tongue pressure than that of normal adults.The swallowing grades assessed by water drinking test showed significant correlations with both the biting force(r=−0.498,P<0.05)and the tongue muscle strength(r=−0.544,P<0.05).The biting force of dysphagia participants correlates significantly with dental conditions(P<0.05).The observed correlation between tongue pressure and diet texture indicates that tongue muscle strength could be used as a reliable indicator of the eating and swallowing capability for elderly people. | Xinmiao Wang Gangying Zheng Mingsong Su Yanqiu Chen Hua Xie Weijia Han Qing Yang Jianqin Sun Jianshe Chen | 2019 | Food Science and Human Wellness2019，8，2： | 4 |
| 16 | Regulating surface state of WO3 nanosheets by gamma irradiation for suppressing hydrogen evolution reaction in electrochemical N2 fixation显示文摘Realizing the reduction of N2 to NH3 at low temperature and pressure is always the unremitting pursuit of scientists and then electrochemical nitrogen reduction reaction offers an intriguing alternative.Here,we develop a feasible way,gamma irradiation,for constructing defective structure on the surface of WO3 nanosheets,which is clearly observed at the atomic scale by high-angle annular dark-field scanning transmission electron microscopy(HAADF-STEM).The abundant oxygen vacancies ensure WO3 nanosheets with a Faradaic efficiency of 23%at−0.3 V vs.RHE.Moreover,we start from the regulation of the surface state to suppress proton availability towards hydrogen evolution reaction(HER)on the active site and thus boost the selectivity of nitrogen reduction. | Yanqiu Du Cheng Jiang Li Song Bin Gao Hao Gong Wei Xia Lei Sheng Tao Wang Jianping He | 2020 | Nano Research2020，13，10： | 4 |
| 17 | Probucol attenuates ethanol‐induced liver fibrosis in rats by inhibiting oxidative stress, extracellular matrix protein accumulation and cytokine production显示文摘 | Xuesong Su Yanqiu Wang Guangyu Zhou Xu Yang Rui Yu Yan Lin Changqing Zheng | 2014 | Clin Exp Pharmacol Physiol2014，，1： | 3 |
| 18 | Study on Electrokinetic Remediation of Cadmium-contaminated Soil显示文摘In order to improve electrokinetic remediation efficiency of cadmium-contaminated soil,the effects of electric field intensity,remediation time and electrolyte on removal rate of total Cd in Cd-contaminated soil by electrokinetic remediation were studied through the preparation of Cd-contaminated soil and the construction of electrokinetic remediation equipment. The results showed that under the same condition,with the electric field intensity increasing from 2. 5 to 3 V/cm,the total Cd removal rate increased by 10. 62%,and with the increase of the electric field intensity from 3 to 3. 5 V/cm,the removal rate increased by 1. 87%;when the remediation time was prolonged from 72 to 96 h,the removal rate of total Cd increased by 6. 68%,and with the remediation time prolonged from 96 to120 h,the removal rate of total Cd increased by 8. 75%; and with the remediation time prolonged from 120 to 144 h,the removal rate of total Cd only increased by1. 07%. Compared with citric acid as the electrolyte,the acetic acid group improved the remediation efficiency by 12. 14% and the total energy consumption by62. 13%,while the hydrochloric acid group improved the remediation efficiency by 18. 04% and the total energy consumption by 187. 9%. Comprehensively from total Cd removal rate and energy consumption,the remediation effect was the best under the electric field intensity of 3 V/cm and the electrokinetic time of 120 h with acetic acid as the electrolyte,which achieved a total Cd removal rate of 41. 95%. | Meng SHEN Yanqiu CHEN Hui HAN Xin WEN Min SHAO Mingxin WANG Yushan WAN | 2019 | Agricultural Biotechnology2019，8，1： | 3 |
| 19 | PagGRF12a interacts with PagGIF1b to regulate secondary xylem development through modulating PagXND1a expression in Populus alba×P.glandulosa显示文摘Growth-regulating factors(GRFs)are important regulators of plant development and growth,but their possible roles in xylem development in woody plants remain unclear.Here,we report that Populus alba×Papulus glandulosa PagGRF12a negatively regulates xylem development in poplar.PagGRF12a is expressed in vascular tissues.Compared to non-transgenic control plants,transgenic poplar plants overexpressing PagGRF12a exhibited reduced xylem width and plants with repressed expression of PagGRF12a exhibited increased xylem width.Xylem NAC domain 1(XND1)encodes a NAC domain transcription factor that regulates xylem development and transcriptional analyses revealed that PagXND1a is highly upregulated in PagGRF12a-overexpressing plants and downregulated in PagGRF12a-suppressed plants,indicating that PagGRF12a may regulate xylem development through PagXND1a.Transient transcriptional assays and chromatin immunoprecipitation-polymerase chain reaction assays confirmed that PagGRF12a directly upregulates PagXND1a.In addition,PagGRF12a interacts with the GRF-Interacting Factor(GIF)PagGIF1b,and this interaction enhances the effects of PagGRF12a on PagXND1a.Our results indicate that PagGRF12a inhibits xylem development by upregulating the expression of PagXND1a. | Jinnan Wang Houjun Zhou Yanqiu Zhao Cheng Jiang Jihong Li Fang Tang Yingli Liu Shutang Zhao Jianjun Hu Xueqin Song MengZhu Lu | 2021 | Journal of Integrative Plant Biology2021，63，10： | 3 |
| 20 | Study on virtual source method under complex overburden in horizontal well显示文摘In conventional seismic exploration,complex overburden prevents us from imaging the deeper underground structure,because near-surface velocity model cannot be efficiently simplified and accurately established. The virtual source method provides a promising solution,which images below a complex overburden without the knowledge of overburden velocities and near-surface changes. In this paper,the authors simulate the forward modeling under complex overburden with sources on the surface and receivers in the horizontal well,and reset the real sources into the horizontal well using the virtual source method,which subtly avoid the distortion effects of the complex overburden. Finally the underground structure can be imaged using Kirchhoff migration,so the feasibility and advantages of the virtual source method are verified. | WANG Le HAN Liguo LIU Yanqiu XU Zhuo | 2014 | Global Geology2014，17，2： | 3 |
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