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| 1 | Temperature and substrate availability regulate soil respiration in the tropical mountain rainforests,Hainan Island,China显示文摘Aims Tropical forest plays a key role in global C cycle;however,there are few studies on the C budget in the tropical rainforests in Asia.This study aims to(i)reveal the seasonal patterns of total soil respiration(R_(T)),litter respiration(R_(L))and soil respiration without surface organic litter(R_(NL))in the primary and secondary Asian tropical mountain rainforests and(ii)quantify the effects of soil temperature,soil moisture and substrate availability on soil respiration.Methods The seasonal dynamics of soil CO_(2) efflux was measured by an automatic chamber system(Li-8100),within the primary and secondary tropical mountain rainforests located at the Jianfengling National Reserve in Hainan Island,China.The litter removal treatment was used to assess the contribution of litter to belowground CO_(2) production.Important Findings The annual R_(T) was higher in the primary forest(16.73±0.87 Mg C ha−1)than in the secondary forest(15.10±0.26 Mg C ha−1).The rates of R_(T),R_(NL) and R_(L) were all significantly higher in the hot and wet season(May–October)than those in the cool and dry season(November–April).Soil temperature at 5cm depth could explain 55–61%of the seasonal variation in R_(T),and the temperature sensitivity index(Q_(10))ranked by R_(L)(Q_(10)=3.39)>R_(T)(2.17)>R_(NL)(1.76)in the primary forest and by R_(L)(4.31)>R_(T)(1.86)>R_(NL)(1.58)in the secondary forest.The contribution of R_(L) to R_(T) was 22–23%,while litter input and R_(T) had 1 month time lag.In addition,the seasonal variation of R_(T) was mainly determined by soil temperature and substrate availability.Our findings suggested that global warming and increased substrate availability are likely to cause considerable losses of soil C in the tropical forests. | Zhang Zhou Lai Jiang Enzai Du Huifeng Hu Yide Li Dexiang Chen Jingyun Fang | 2013 | Journal of Plant Ecology2013，6，5： | 8 |
| 2 | Fluoro-Hydroxylation of gem-Difluoroalkenes:Synthesis of 18O-labeled α-CF3 Alcohols显示文摘in this paper,a fluoro-hydroxylation of gem-difluoroalkenes is demonstrated.This protocol uses sequential electrophilic fluorination with Selectfluor and nucleophilic hydroxylation with H218o,which can be used to prepare 18Oo-labeled α-CF3 alcohols from gem-difluorostyrenes.The reaction is typically carried out at room temperature within 4h in good to excellent yields.Other nucleophiles (besides H218o),such as alcohols,carboxylic acid, acetonitrile and N,N-dimethylformamide,are also suitable for this difunctionalization of gem-difluoroalkenes. | Jingyu Hu Yide Yang Zhengzhao Lou Chuanfa Ni Jinbo Hu | 2018 | Chinese Journal of Chemistry2018，36，12： | 3 |
| 3 | A Facile and Effective Method for the Distribution of Mo/HZSM-5 Catalyst Active Centers显示文摘 | Hongxia Wang Gang Hu Hao Lei Yide Xu Xinhe Bao | 2003 | Catalysis Letters (-)2003，，1： | 1 |
| 4 | Role of HOXB7 in regulation of progression and metastasis of human lung adenocarcinoma显示文摘 | Weiwei Yuan Xuelin Zhang Yu Xu Shasha Li Yide Hu Shiyong Wu | 2014 | Mol Carcinog2014，，1： | 1 |
| 5 | Review:Recent Advancement of Experimental and Numerical Investigations for Breaking Waves显示文摘Breaking wave is a complex physical phenomenon that takes place at the gas fluid interface which is the chief reason for the generation of two phase turbulence wave energy dissipation and mass transfer between air and water. For marine hydrodynamics the breaking bow wave of high speed vessels induces the bubble mixed flow travelling around the ship eventually developing to be the turbulent wake which is easy to be detected by photoelectric equipment. Besides the flow induced noise stemming from wave plunging may weaken the acoustic stealth of water surface craft. In the oceanographic physics context wave breaking accounts for the energy and mass exchange of the ocean atmosphere system which has a great effect on the weather forecasts and global climate predictions. Due to multi scale properties of multiphase turbulent flows a wide range of time and length scales should be resolved making it rather complicated for experimental and numerical investigations. In early reviews[1-4] general mechanisms related to wave breaking problems are well described. However previous emphasis lies on the phenomenological characteristics of breaking wave. Thus this review summarizes the recent experimental and numerical advances of the studies of air entrainment bubble distribution energy dissipation capillary effect and so on. | Cheng Liu Yiding Hu Zheng Li Decheng Wan | 2019 | Journal of Harbin Institute of Technology(New Series)2019，26，5： | 1 |
| 6 | Whole-body PET tracking of a D-dodecapeptide and its radiotheranostic potential for PD-L1 overexpressing tumors显示文摘Peptides that are composed of dextrorotary(D)-amino acids have gained increasing attention as a potential therapeutic class.However,our understanding of the in vivo fate of D-peptides is limited.This highlights the need for whole-body,quantitative tracking of D-peptides to better understand how they interact with the living body.Here,we used mouse models to track the movement of a programmed death-ligand 1(PD-L1)-targeting D-dodecapeptide antagonist(DPA)using positron emission tomography(PET).More specifically,we profiled the metabolic routes of[^(64)Cu]DPA and investigated the tumor engagement of[^(64)Cu/^(68)Ga]DPA in mouse models.Our results revealed that intact[^(64)Cu/^(68)Ga]DPA was primarily eliminated by the kidneys and had a notable accumulation in tumors.Moreover,a single dose of[^(64)Cu]DPA effectively delayed tumor growth and improved the survival of mice.Collectively,these results not only deepen our knowledge of the in vivo fate of D-peptides,but also underscore the utility of D-peptides as radiopharmaceuticals. | Kuan Hu Wenyu Wu Lin Xie Hao Geng Yiding Zhang Masayuki Hanyu Lulu Zhang Yinghuan Liu Kotaro Nagatsu Hisashi Suzuki Jialin Guo Yundong Wu Zigang Li Feng Wang Mingrong Zhang | 2022 | Acta Pharmaceutica Sinica B2022，12，3： | 1 |
| 7 | Bmil基因表达抑制对肺腺癌干细胞自我更新、增殖作用的初步研究(英文)显示文摘Objective: The aim of the study was to observe the effect of Bmi1 reduction on the self-renewal and tumorigenicity ability of lung cancer stem cells (LCSCs) in human lung adenocarcinoma. Methods: Human lung adenocarcinoma cells A549 were consecutively passaged in NOD/SCID mice treated with Paclitaxel weekly. The proportions of LCSCs in A549 cells and the cells from the third passage (A549-3rd) were compared. The expression of Bmi1 in LCSCs was silenced by intratumoral injection with lentivirus-delivered Bmi1 small hairpin RNA (shRNA). RT-PCR and Western blot were used to test the mRNA and protein expressions of Bmi1 in LCSCs. The protein level of p16INK4A was analyzed by Western blotting. The self-renewal and tumorigenicity ability of LCSCs were evaluated by counting the sphere formation rate in serum-free medium and the tumor formation rate in NOD/SCID mice. Results: In vivo passaging of A549 cells under chemotherapy pressure enriched for LCSCs. The expression of Bmi1 in LCSCs increased. Down-regulation of Bmi1 by RNA interference resulted in reduced self-renewal and tumorigenicity ability of LCSCs and paralleled the increased expression of p16INK4A, a Bmi1 target. Conclusion: Bmi1 regulates self-renewal and tumorigenicity of LCSCs by silencing some target genes, including p16INK4A. | Jing Zhou Yu XU Ping Hao Yide Hu | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，11： | 0 |
| 8 | YSO coded aperture camera based on depth of interaction for location correction显示文摘Purpose Coded aperture imaging was a widely used imaging method for radiation sources.However,the traditional gamma camera based on two-dimensional projection information for coded aperture imaging ignored the influence of the interaction depth of particles and detectors on the projection information,which reduced the imaging quality of the camera to some extent.Therefore,a method of correcting the coded gamma camera based on the interaction depth of particles and detectors is proposed to improve the location accuracy of detectors.Methods The camera developed in this work uses a 7×7 YSO crystal array coupled with two 7×7 Si-PM arrays.The crystal is evenly divided into 11 parts in the depth direction,with a voxel size of 3×3×3 mm3.The coded mask is a 13×13 array,which is a mosaic of two cycles of 7×7 modified uniformly redundant array mask.The depth resolution of the detector is obtained via the subsurface laser engraving dual-end readout method.After obtaining the three-dimensional position information of the interaction point the projection information obtained by the detector is layered,and the image is reconstructed.According to the spatial position information of the detector and the coded mask,the corresponding field of view of each layer of the detector is calculated,and the reconstructed image of each layer is amplified and superimposed according to the ratio of the field of view to obtain the reconstructed image combined with the depth information.Results and conclusion According to Monte Carlo simulation and radiation source imaging experiment results,this method can effectively improve the positioning ability of the detector.For the experimental scenario mentioned in the paper,the location accuracy can be improved by up to 1.54°. | Yiding Han Xiaopan Jiang Haohui Tang Xiuzuo Liang Xuanhou Hu Xianchao Huang Zhiming Zhang Lei Shuai Jing Guo Long Wei | 2023 | Radiation Detection Technology and Methods2023，7，4： | 0 |
| 9 | CACA Guidelines for Holistic Integrative Management of Breast Cancer显示文摘Purpose:Breast cancer is now the most common malignant tumor worldwide.About one-fourth of female cancer patients all over the world sufer from breast cancer.And about one in six female cancer deaths worldwide is caused by breast cancer.In terms of absolute numbers of cases and deaths,China ranks frst in the world.The CACA Guidelines for Holistic Integrative Management of Breast Cancer were edited to help improve the diagnosis and comprehensive treatment in China.Methods:The Grading of Recommendations Assessment,Development and Evaluation(GRADE)was used to classify evidence and consensus.Results:The CACA Guidelines for Holistic Integrative Management of Breast Cancer include the epidemiology of breast cancer,breast cancer screening,breast cancer diagnosis,early breast cancer treatment,advanced breast cancer treatment,follow-up,rehabilitation,and traditional Chinese medicine treatment of breast cancer patients.Conclusion:We to standardize the diagnosis and treatment of breast cancer in China through the formulation of the CACA Guidelines. | Jiong Wu Daiming Fan Zhimin Shao Binghe Xu Guosheng Ren Zefei Jiang Yongsheng Wang Feng Jin Jin Zhang Qingyuan Zhang Fei Ma Jinli Ma Zhonghua Wang Shusen Wang Xiaojia Wang Shu Wang Haibo Wang Tao Wang Xiang Wang Jing Wang Jia Wang Biyun Wang Li Fu Hongyuan Li Yehui Shi Lu Gan Yunjiang Liu Jian Liu Zhenzhen Liu Qiang Liu Qiang Sun Wenwu Cheng Keda Yu Zhongsheng Tong Xinhong Wu Chuangui Song Jianguo Zhang Jian Zhang Junjie Li Bin Li Man Li Huiping Li Wentao Yang Hongjian Yang Benlong Yang Hong Bu Juping Shen Zhenzhou Shen Yiding Chen Ceshi Chen Da Pang Zhimin Fan Ying Zheng Xiaoli Yu Guangyu Liu Xichun Hu Yiqun Ling Jinhai Tang Yongmei Yin Cuizhi Geng Peng Yuan Yajia Gu Cai Chang Xuchen Cao Yuan Sheng Yuanxi Huang Jian Huang Weijun Peng Xiaohua Zeng Yuntao Xie Ning Liao Committee of Breast Cancer Society,Chinese Anti-Cancer Association | 2022 | Holistic Integrative Oncology2022，1，1： | 0 |
| 10 | Study on the Toxicity of Acetochlor to Loaches显示文摘[Objectives] This study was conducted to investigate the toxic effect of acetochlor in loaches. [Methods]Loaches were put into the acetochlor solution with concentrations of 0,0. 062 5,0. 125,0. 25,0. 5 and 1 μl/L,respectively. The effects on dismutase( SOD),peroxidase( POD),catalase( CAT) and glutathione( GSH) activity and malondialdehyde( MDA) content in the liver of loaches were analyzed after 12,24,48 and 72 h of exposure. [Results] The activity of SOD,POD,CAT and GSH increased with the stress time and concentration,reached their maximums at 48 h after acetochlor treatment,and then decreased.However,MDA content increased with the stress time and concentration. [Conclusions] Acetochlor had obvious oxidative stress on loaches,and the activity of SOD,POD,CAT and GSH showed an obvious induction-inhibition effect with the increase of acetochlor concentration and the extension of stress time. | Yan WANG Peng DONG Pei XU Yuxiang LIN Zexin CHEN Yihong HU Chenzhong JIN Yiding WANG Kaifa GUO Qianxia ZHU | 2020 | Agricultural Biotechnology2020，9，3： | 0 |
| 11 | Development of a highly-specific ^(18)F-labeled irreversible positron emission tomography tracer for monoacylglycerol lipase mapping显示文摘As a serine hydrolase,monoacylglycerol lipase(MAGL) is principally responsible for the metabolism of 2-arachidonoylglycerol(2-AG) in the central nervous system(CNS),leading to the formation of arachidonic acid(AA).Dysfunction of MAGL has been associated with multiple CNS disorders and symptoms,including neuroinflammation,cognitive impairment,epileptogenesis,nociception and neurodegenerative diseases.Inhibition of MAGL provides a promising therapeutic direction for the treatment of these conditions,and a MAGL positron emission tomography(PET) probe would greatly facilitate preclinical and clinical development of MAGL inhibitors.Herein,we design and synthesize a small library of fluoropyridyl-containing MAGL inhibitor candidates.Pharmacological evaluation of these candidates by activity-based protein profiling identified 14 as a lead compound,which was then radiolabeled with fluorine-18 via a facile SNAr reaction to form 2-[^(18)F]fluoropyridine scaffold.Good blood-brain barrier permeability and high in vivo specific binding was demonstrated for radioligand [^(18)F]14(also named as [^(18)F]MAGL-1902).This work may serve as a roadmap for clinical translation and further design of potent 18F-labeled MAGL PET tracers. | Zhen Chen Wakana Mori Jian Rong Michael A.Schafroth Tuo Shao Richard S.Van Daisuke Ogasawara Tomoteru Yamasaki Atsuto Hiraishi Akiko Hatori Jiahui Chen Yiding Zhang Kuan Hu Masayuki Fujinaga Jiyun Sun Qingzhen Yu Thomas L.Collier Yihan Shao Benjamin F.Cravatt Lee Josephson Ming-Rong Zhang Steven H.Liang | 2021 | Acta Pharmaceutica Sinica B2021，11，6： | 0 |
| 12 | DNA-Based Architectures for in situ Target Biomolecule Analysis in Confined Nano-space显示文摘In situ target biomolecule analysis is of great significance for real-time monitoring and regulation of endogenous biomarkers and elementary biomolecules in vivo.Gratifyingly,the rapid evolution of structural DNA nanotechnology during past decades has established an appealing toolbox for biological analysis and medical detection.The modulated self-assembly and underlying canonical Watson-Crick base-pairing rules provide possibilities for accurate controlling of the topologies and functions of obtained nanomaterials.The probes composed of diverse DNA nanostructures and DNA-nanoparticle complexes can create a confined space,which increases target accessibility and improves probe stability,sensitivity and specificity.In this minireview,we retrospect the research progress of in-situ biomolecular analysis based on DNA nanostructures for intracellular and in vivo biosensors in confined space.The characteristics of distinct DNA nanomaterials are first introduced,and then the fundamentals of biosensing process of designed DNA nanostructures are emphasized.Moreover,we elucidate our perspective over the challenges of this field and discuss the potential directions of this kind of application-oriented fabrication technique. | Xiaoxue Hu Yide Huang Hao Yin Lizhi Dai Ye Tian | 2021 | Chinese Journal of Chemistry2021，39，7： | 0 |
| 13 | 去甲苔藓蒽噻吩抑制血管生成作用的体外实验研究(英文)显示文摘Objective:The aim of the study was to investigate the effect of Demethyl bryoanthrathiophene(DBT) on proliferations of human umbilical vein endothelial cells(HUVECs) and human lung adenocarcinoma cell line A549,and antiangiogenic effect of DBT on HUVECs in vitro.Methods:MTT assay was used to observe the effect of DBT on proliferations of HUVECs and A549 cells,flat plate scarification assay and tube formation in vitro test were used to observe the impact of DBT on migration and vaso-formed ability of HUVECs.The effects of DBT on apoptosis and cell cycle of HUVECs were calculated by flow cytometry.Results:MTT assay showed that treatment with DBT resulted in strong inhibition to the growth of HUVECs and A549 cells.The inhibition effects of DBT on HUVECs and A549 cells were related to dosage and times of dependency.In different doses of DBT(0.16,0.32 and 0.48 μmol/L) of flat plate scarification for 24 h,inhibition rates of DBT to migration of HUVECs were 14.70%,38.23% and 58.82%,respectively.In dose of DBT from 0.04,0.20 to 0.40 μmol/L for 24 h in tube formation,there were significance differences(P < 0.01) in the decreasing number of angiogenesis and incomplete blood vessel compared with control groups.All results showed that DBT promoted the apoptosis rate of HUVECs,and the increase of concentration of DBT accompanied the acceleration of apoptosis rate.Conclusion:DBT could inhibit the proliferations of HUVECs and A549 cells,and effectively suppress angiogenesis in vitro. | Chen Zhong Xiangdong Zhou Minghui Zhang Yide Hu | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，2： | 0 |
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