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| 1 | A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV) infected pneumonia(standard version)显示文摘In December 2019, a new type viral pneumonia cases occurred in Wuhan, Hubei Province;and then named '2019 novel coronavirus(2019-nCoV)' by the World Health Organization(WHO) on 12 January 2020. For it is a never been experienced respiratory disease before and with infection ability widely and quickly, it attracted the world’s attention but without treatment and control manual. For the request from frontline clinicians and public health professionals of 2019-nCoV infected pneumonia management, an evidence-based guideline urgently needs to be developed. Therefore, we drafted this guideline according to the rapid advice guidelines methodology and general rules of WHO guideline development;we also added the first-hand management data of Zhongnan Hospital of Wuhan University. This guideline includes the guideline methodology, epidemiological characteristics, disease screening and population prevention, diagnosis, treatment and control(including traditional Chinese Medicine), nosocomial infection prevention and control, and disease nursing of the 2019-nCoV. Moreover, we also provide a whole process of a successful treatment case of the severe 2019-nCoV infected pneumonia and experience and lessons of hospital rescue for 2019-nCoV infections. This rapid advice guideline is suitable for the first frontline doctors and nurses, managers of hospitals and healthcare sections, community residents, public health persons, relevant researchers, and all person who are interested in the 2019-nCoV. | Ying-Hui Jin Lin Cai Zhen-Shun Cheng Hong Cheng Tong Deng Yi-Pin Fan Cheng Fang Di Huang Lu-Qi Huang Qiao Huang Yong Han Bo Hu Fen Hu Bing-Hui Li Yi-Rong Li Ke Liang Li-Kai Lin Li-Sha Luo Jing Ma Lin-Lu Ma Zhi-Yong Peng Yun-Bao Pan Zhen-Yu Pan Xue-Qun Ren Hui-Min Sun Ying Wang Yun-Yun Wang Hong Weng Chao-Jie Wei Dong-Fang Wu Jian Xia Yong Xiong Hai-Bo Xu Xiao-Mei Yao Yu-Feng Yuan Tai-Sheng Ye Xiao-Chun Zhang Ying-Wen Zhang Yin-Gao Zhang Hua-Min Zhang Yan Zhao Ming-Juan Zhao Hao Zi Xian-Tao Zeng Yong-Yan Wang Xing-Huan Wang 无 | 2020 | Military Medical Research2020，7，1： | 161 |
| 2 | Analysis of Factors Associated with Death in Maintenance Hemodialysis Patients: A Multicenter Study in China显示文摘 | Kang-Kang Song De-Long Zhao Yuan-Da Wang Yong Wang Xue-Feng Sun Li-Ning Miao Zhao-Hui Ni Hong-Li Lin Fu-You Liu Ying Li Ya-Ni He Nian-Song Wang Cai-Li Wang Ai-Hua Zhang Meng-Hua Chen Xiao-Ping Yang Yue-Yi Deng Feng-Min Shao Shu-Xia Fu Jing-Ai Fang Guang-Yan Cai Xiang-Mei Chen | 2017 | Chinese Medical Journal2017，，8： | 39 |
| 3 | Dissection of genetic overlap of salt tolerance QTLs at the seedling and tillering stages using backcross introgression lines in rice显示文摘QTLs for salt-tolerance(ST)related traits at the seedling and tillering stages were identified using 99 BC2F8 introgression lines(IL)derived from a cross between IR64(indica)as a recurrent parent and Binam(japonica)from Iran as the donor parent.Thirteen QTLs affecting survival days of seedlings(SDS), score of salt toxicity of leaves(SST),shoot K + concentration(SKC)and shoot Na + concentration(SNC) at the seedling stage and 22 QTLs underlying fresh weight of shoots(FW),tiller number per plant(TN) and plant height(PH)at the tillering stage were identified.Most QTLs detected at the tillering stage showed obvious differential expression to salt stress and were classified into three types based on their differential behaviors.Type I included 11 QTLs which were expressed only under the non-stress condition.Type II included five QTLs expressed in the control and the salt stress conditions,and three of them(QPh5,QPh8 and QTn9)had similar quantity and the same direction of gene effect,suggesting their expression was less influenced by salt stress.Type III included six QTLs which were detectable only under salt stress,suggesting that these QTLs were apparently induced by the stress.Thirteen QTLs affecting trait difference or trait stability of ILs between the stress and non-stress conditions were identified and the Binam alleles at all loci except QPh4,QTn2 and QFw2a decreased trait difference.The three QTLs less influenced by the stress and 13 QTLs affecting trait stability were considered as ST QTLs which contributed to ST.Comparing the distribution of QTLs detected at the seedling and tillering stages,most(69%)of them were genetically independent.Only four were the same or adjacent regions on chromosomes 1,2,8 and 11 harboring ST QTLs detected at the two stages,suggesting that partial genetic overlap of ST across the two stages occurs.It is likely,therefore,to develop ST rice variety for both stages by pyramiding of ST QTLs of different stages or selection against the overlapping QTLs between the two stages via marker-assisted selection(MAS). | ZANG JinPing 1 ,SUN Yong 1 ,WANG Yun 1 ,YANG Jing 1 ,LI Fang 1 ,ZHOU YongLi 1 ,ZHU LingHua 1 , Reys JESSICA2,Fotokian MOHAMMADHOSEIN 2,XU JianLong 1&LI ZhiKang 1,2 1Institute of Crop Sciences/National Key Facility for Crop Gene Resources&Genetic Improvement,Chinese Academy of Agricul- tural Sciences,Beijing 100081,China 2International Rice Research Institute,DAPO Box 7777,Metro Manila,Philippines | 2008 | Science China(Life Sciences)2008，51，7： | 32 |
| 4 | Polymorphism of p16INK4a gene and rare mutation of p15INK4b gene exon2 in primary hepatocarcinoma显示文摘INTRODUCTION Hepatocellular carcinoma(HCC)is the mostcommon cause of death from cancer in China.Themechanisms of hepatocarcinogenesis are not yetknown clearly,p16INK4a gene,the multiple tumorsuppressor gene 1(MTS1),encodes P16 protein,which acts as an inhibitor by binding directly toCDK4 and CDK6 and preventing its association | Yang Qin Bo Li Yong Shu Tan Zhi Lin Sun Feng Qiong Zuo Ze Fang Sun Institute of Biochemistry and Molecular Biology,West China University of Medical Sciences,Chengdu 610041,Sichuan Province,China Department of General Surgery,The First Affiliated Hospital,West China University of Medical Sciences,Chengdu 610041,Sichuan Province,China Department of Pathology,The First Affiliated Hospital,West China University of Medical Sciences,Chengdu 610041,Sichuan Province,China | 2000 | World Journal of Gastroenterology2000，6，3： | 30 |
| 5 | Case-based learning in education of Traditional Chinese Medicine: a systematic review显示文摘OBJECTIVE:To assess the effect of case-based learning(CBL)in the education of Traditional Chinese Medicine(TCM).METHODS:The studies concerning TCM courses designed with CBL were included by searching the databases of EBSCO,Pubmed,Science Citation Index,China National Knowledge Infrastructure,Chongqing VIP database.The valid data was extracted in accordance with the included criteria.The quality of the studies was assessed with Gemma Flores-Masteo.RESULTS:A total of 22 articles were retrieved that met the selection criteria:one was of high quality;two were of low quality;the rest were categorized as moderate quality.The majority of the studiesdemonstrated the better effect produced by CBL,while a few studies showed no difference,compared with the didactic format.All included studies confirmed the favorable effect on learners'attitude,skills and ability.CONCLUSION:CBL showed the desirable results in achieving the goal of learning.Compared to didactic approach,it played a more active role in promoting students'competency.Since the quality of the articles on which the study was based was not so high,the findings still need further research to become substantiated. | Ji Chen Ying Li Yong Tang Fang Zeng Xi Wu Fanrong Liang | 2013 | Journal of Traditional Chinese Medicine2013，33，5： | 30 |
| 6 | Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study显示文摘Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy. | Zhi Peng Tianshu Liu Jia Wei Airong Wang Yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming Xu Qingxia Fan Ruihua Xu Liangming Zhang Enxiao Li Yuping Sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer Ying Xinjun Liang Nong Xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang Yi Ba Lin Shen | 2021 | Cancer Communications2021，41，11： | 29 |
| 7 | A study of the efficacy of bacterial biofilm cleanout for gastrointestinal endoscopes显示文摘AIM:To compare the influence and clearance effect of enzymatic and non-enzymatic detergents against Escherichia coli (E. coli) biofilm on the inner surface of gastroscopes.METHODS:Teflon tubes were incubated in a mixture of different detergents and E. coli culture (106 CFU/mL) for 72 h at 15℃,and biofilms on the inner surface of the teflon tubes were analyzed by bacterial count and scanning electron microscopy. To evaluate the clear-ance effect of detergents,after biofilms were formed on the inner surface of Teflon tubes by 72 h lavage with E. coli culture,tubes were lavaged by enzymatic and non-enzymatic detergents at a speed of 250 mL/min,then biofilms on the inner surface were analyzed by bacterial count and scanning electron microscopy.RESULTS:Non-enzymatic detergent had a better inhi-bition function on biofilm formation than enzymatic de-tergent as it reduced bacterial burden by 2.4 log compared with the control samples (P = 0.00). Inhibition function of enzymatic detergent was not significantly different to that of control samples and reduced bac-terial burden by 0.2 log on average (P > 0.05). After lavaging at 250 mL/min for 3 min,no living bacteria were left in the tubes. Scanning electron microscopy observation showed biofi lms became very loose by the high shear force effect. CONCLUSION:Non-enzymatic detergent has a better inhibition effect on biofilm formation at room temperature. High speed pre-lavage and detergents are very important in temporal formed biofilm elimination. | Fang, Ying Shen, Zhe Li, Lan Cao, Yong Gu, Li-Ying Gu, Qing Zhong, Xiao-Qi Yu, Chao-Hui Li, You-Ming | 2010 | World Journal of Gastroenterology2010，16，8： | 28 |
| 8 | Different histological subtypes of parotid gland tumors: CT findings and diagnostic strategy显示文摘AIM:To present computed tomography(CT) findings of different histological subtypes of parotid gland masses in detail and to establish diagnostic strategy.METHODS:From January 2009 to November 2011,56 patients were collected through the histopathology and Picture Archiving and Communication Systems records,which revealed 5 basal cell adenoma(BCA),16 pleomorphic adenoma(PA),25 Warthin's tumor(War-T),3 Kimura's disease(KD) and 7 parotid carcinoma(PCa) cases.All the CT images were retrospectively analyzed by two radiologists in consensus,based on their description of morphology(location,number,size,margin and fibrous capsule) and enhancement patterns of masses.In addition,the diagnostic efficiency of diagnostic strategy is tested.RESULTS:War-T and BCA patients' mean age was 59.9 ± 12.6 years and 58.4 ± 18.2 years;the significant difference was seen in War-T vs PA and BCA vs PA.About 40% of War-Ts presented with bilateral multifocal lesions,a higher ratio than others.Seventy two percent of War-Ts were limited to the superficial lobe,followed by BCA 60% and PA 40%.Vessel facing sign and enlarged lymph nodes were both frequent in War-T,which respectively accounts for 84% and 76% of cases.Rapid contrast enhancement and decreases were unique for War-T.BCA and PA showed obvious delayed enhancement.The diagnostic strategy of parotid gland tumor had a good diagnostic efficiency,with high accuracy,sensitivity and specificity.CONCLUSION:Determination of the histological subtypes of parotid gland masses might be possible based on CT findings and clinical data.A diagnostic strategy with high diagnostic efficiency was established. | Zhi-Feng Xu Fang Yong Tian Yu Ying-Yu Chen Qiang Gao Tao Zhou Ai-Zhen Pan Ren-Hua Wu | 2013 | World Journal of Radiology2013，5，8： | 25 |
| 9 | Antisense telomerase RNA induced human gastric cancer cell apoptosis显示文摘INTRODUCTION Human tissue homeostasis is precisely regulated bycellular division,differentiation and death.Normalhuman somatic cells progressively lose telomererestriction fragment(TRF)length with eachsuccessive cell division,eventually leading tocellular quiescence,chromosomal end-degradationand apoptosis.On the contrary,stabilization oftelomere lengths by expressing telomerase,an RNA-dependent DNA polymerase,may be involved incellular immortality and carcinogenesis. | Fang Xin Zhang Xue Yong Zhang Dai Ming Fan Zi Yun Deng Yan Yan Han Ping Wu Jun Jie Fan | 2000 | World Journal of Gastroenterology2000，6，3： | 24 |
| 10 | Transduction of Fas gene or Bcl-2 antisense RNA sensitizes cultured drug resistant gastric cancer cells to chemotherapeutic drugs显示文摘INTRODUCTIONChemotherapyisoneofthemajormethodsintumortreatment,butitoftendoesnotworkduetomultidrugresistance(MDR).Recentstudi... | XIAO Bing, SHI Yong Quan, ZHAO Yan Qiu, YOU Han, WANG Zuo You, LIU Xian Ling, YIN Fang, QIAO Tai Dong and FAN Dai Ming | 1998 | World Journal of Gastroenterology1998，4，5： | 24 |
| 11 | Clinicopathologic characteristics and prognosis of gastroenteropancreatic neuroendocrine neoplasms: a multicenter study in South China显示文摘Background: Gastroenteropancreatic neuroendocrine neoplasms(GEP-NENs) are a heterogeneous group of rare tumors. Many issues in terms of epidemiologic features, pathogenesis, and treatment of GEP-NENs are still under discussion. Our study aimed to analyze the clinicopathologic characteristics and prognosis of Chinese patients with GEP-NENs.Methods: Complete clinicopathologic data and survival information of 1183 patients with GEP-NENs treated between 2005 and 2015 were collected from five medical centers in Guangdong Province, China. Patient survival was estimated using the Kaplan–Meier method and analyzed using the log-rank test; prognostic factors were analyzed using the Cox proportional hazards model.Results: The most common tumor location was the rectum(37.4%), followed by the pancreas(28.1%), stomach(20.7%), small intestine(7.2%), appendix(3.4%), and colon(3.3%). After initial definitive diagnosis, 1016(85.9%) patients underwent surgery. The 1-, 3-, and 5-year overall survival(OS) rates for the entire cohort were 87.9%, 78.5%, and 72.8%, respectively. The 3-year OS rates of patients with G1, G2, and G3 tumors were 93.1%, 82.7%, and 43.1%, respectively(P < 0.001). The 3-year OS rates of patients with stage I, II, III, and IV tumors were 96.0%, 87.3%, 64.0%, and 46.8%, respectively(P < 0.001). Patients with distant metastasis who underwent palliative surgery had a longer survival than those who did not(P = 0.003). Similar survival benefits of palliative surgery were observed in patients with neuroendocrine tumor(P y, M category, and sur= 0.031) or neuroendocrine carcinoma(P gery were found to be independent prog= 0.046). In multivariate analysis, age, grade, N categornostic factors.Conclusions: Patients with GEP-NENs who are women, younger than 50 years old, have smaller tumor size, have lower tumor grade, have lower T/N/M category, and who undergo surgery can have potentially longer survival time. Our data showed that surgery can improve the prognosis of GEP-NEN patients with distant metastasis. However, randomized controlled trials need to be conducted to establish the optimal criteria for selecting patients to undergo surgery. | Cheng Fang Wei Wang Yu Zhang Xingyu Feng Jian Sun Yujie Zeng Ye Chen Yong Li Minhu Chen Zhiwei Zhou Jie Chen | 2017 | Chinese Journal of Cancer2017，36，10： | 23 |
| 12 | Surface settlement caused by twin-parallel shield tunnelling in sandy cobble strata显示文摘City metro tunnels are usually constructed as twin-parallel tunnels and their adjacent construction may lead to surface deformation,affecting the surface environment and the safety of the tunnels.Due to its strong dispersion,sandy cobble strata can be easily disturbed by shield tunneling.Based on the project of the Chengdu Metro Line 1,field and model tests were carried out to study the surface settlement caused by shield tunneling in sandy cobble strata by measuring surface settlement curves,ground loss ratios and construction influence zones.The discrete element method(DEM) was used to study the factors affecting the formation of ground arches in sandy cobble strata at the microscopic level.Results show that the shape of the surface settlement curve in sandy cobble strata is different from that in soft soil.The buried depth and clear spacing of the two tunnels had a significant impact on the formation of ground arches. | Chuan HE Kun FENG Yong FANG Ying-chao JIANG | 2012 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2012，13，11： | 21 |
| 13 | The development of China's Yangtze River Economic Belt:how to make it in a green way?显示文摘The Yangtze River is one of the largest and longest rivers in Asia.The river originates in the Tibet-Qinghai Plateau(headwater reach),passes through the mountainous provinces of Sichuan,Yunnan and Chongqing(upper reach),flows into the Central Plain(middle reach)and Lower Plain(lower reach),and finally empties into the East China Sea in Shanghai(estuary).The Yangtze River Economic Belt(YREB;Fig.1)has a surface area of 2.1 | Yushun Chen Shuanghu Zhang Desheng Huang Bai-Lian Li Junguo Liu Wenjin Liu Jing Ma Fang Wang Yong Wang Shengjun Wu Yegang Wu Jinyue Yan Chuanbo Guo Wei Xin Hao Wang | 2017 | Science Bulletin2017，62，9： | 20 |
| 14 | 基于轮廓特征及灰度相似度匹配的接触网绝缘子缺陷检测(英文)显示文摘目的:在图像缺陷样本少和一致性差的情况下,实现精确可靠的接触网绝缘子缺陷检测。创新点:提山一种基于瓷片轮廓特征及灰度相似度匹配的融合算法,实现了绝缘子瓷片的轮廓提取及绝缘子各瓷片的精准分离,并构建了基于瓷片间距和灰度相似度匹配的绝缘子缺陷检测模型。方法:1.采用同一个绝缘子相邻瓷片两两比较的方法进行缺陷检测,解决图像缺陷样本少和一致性差的问题。2.分两步进行检测(Fig.2):(1)基于水平梯度特征提取绝缘子各瓷片轮廓,并对瓷片轮廓内像素进行复原;(2)计算瓷片间距和灰度相似度,并与设置的阈值进行比较以区分正常绝缘子和缺陷绝缘子。结论:1.实验表明,基于轮廓特征及灰度相似度匹配的方法能够有效区分正常绝缘子和缺陷绝缘子。2.在图片数据集中,测试达到了99.50%的高召回率和91.71%的高精确度,满足了目前较高水平的接触网绝缘子缺陷检测的要求。 | Ping TAN Xu-feng LI Jin-mei XU Ji-en MA Fei-jie WANG Jin DING You-tong FANG Yong NING | 2020 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2020，21，1： | 19 |
| 15 | Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC)is a poor-prognosis cancer type with limited understanding of its molecular etiology.Using 508 ESCC genomes,we identified five novel significantly mutated genes and uncovered mutational signature clusters associated with metastasis and patients’outcomes.Several functional assays implicated that NFE2L2 may act as a tumor suppressor in ESCC and that mutations in NFE2L2 probably impaired its tumor-suppressive function,or even conferred oncogenic activities.Additionally,we found that the NFE2L2 mutations were significantly associated with worse prognosis of ESCC.We also identified potential noncoding driver mutations including hotspot mutations in the promoter region of SLC35E2 that were correlated with worse survival.Approximately 5.9%and 15.2%of patients had high tumor mutation burden or actionable mutations,respectively,and may benefit from immunotherapy or targeted therapies.We found clinically relevant coding and noncoding genomic alterations and revealed three major subtypes that robustly predicted patients’outcomes.Collectively,we report the largest dataset of genomic profiling of ESCC useful for developing ESCC-specific biomarkers for diagnosis and treatment. | Yongping Cui Hongyan Chen Ruibin Xi Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qimin Zhan Yanhong Li Zhihua Liu-Show | 2020 | Cell Research2020，30，10： | 19 |
| 16 | The mortality of lung cancer attributable to smoking among adults in China and the United States during 1990–2017显示文摘Background:Statistical data on the burden and relevant risk factors of lung cancer are valuable for policy-making.This study aimed to compare the mortality of lung cancer attributable to smoking stratified by sex and age among adults in China and the United States(US).Methods:We extracted age-standardized mortality rates of lung cancer during 1990-2017 using the comparative risk assessment framework of the 2017 Global Burden of Disease study.We performed an age-period-cohort analysis to estimate time trend of lung cancer mortality attributable to smoking.Results:During 1990-2017,the age-standardized mortality rate of lung cancer was increasing in China but decreasing in the US for both sexes.The mortality attributable to smoking in China showed a generally increasing trend,while a continuous decrease was observed in the US.The age-period-cohort analysis showed a similar trend of age effect among adults between China and the US:the mortality substantially increased from the 30-34 to 80-84 age group and subsequently decreased in the 90-94 age group.However,the period effect rapidly increased in Chinese adults during 1990-2017,while it tended to be stable in the US although it was still slightly increasing in women.The cohort effect generally peaked in the earlier cohort born in 1902-1906 in the two countries.Conclusions:During 1990-2017,the lung cancer mortality attributable to smoking and the period effect are generally increasing in Chinese adults;the mortality attributable to smoking is decreasing in the US adults,but the period effect tends to be stable.The rapid aging and prevalence of smoking may intensify the increasing mortality of lung cancer in China. | Xiaoxue Liu Yong Yu Minsheng Wang Sumaira Mubarik Fang Wang Yafeng Wang Runtang Meng Chuanhua Yu | 2020 | Cancer Communications2020，40，11： | 17 |
| 17 | Genetic analysis and molecular mapping of a presenescing leaf gene psll in rice (Oryza sativa L.)显示文摘A rice psl1 (presenescing leaf) mutant was obtained from a japonica variety Zhonghua 11 via radiation of 60Co-γ in M2 generation. Every leaf of the mutant began to wither after it reached the big-gest length,while the leaves of the wild variety could keep green for 25―35 d. In this study,genetic analysis and gene mapping were carried out for the mutant identified. The SSR marker analysis showed that the mutant was controlled by a single recessive gene (psl1) located on chromosome 2. Fine mapping of the psl1 locus was conducted with 34 new STS markers developed around psl1 anchored region based on the sequence diversity between Nippon-bare and 93-11. The psl1 was further mapped be-tween two STS markers,STS2-19 and STS2-26,with genetic distances of 0.43 and 0.11 cM,respectively,while cosegregated with STS2-25. A BAC contig was found to span the psl1 locus,the region being delim-ited to 48 kb. This result was very useful for cloning of the psl1 gene. | WANG dun WU Shujun ZHOU Yong ZHOU Lihui XU Jiefen HU Jing FANG Yunxia GU Minghong LIANG Guohua | 2006 | Chinese Science Bulletin2006，51，24： | 16 |
| 18 | Toward a Harmonious Unifying Hybrid Model for any Evolving Complex Networks显示文摘The basic concept and method for the HUHPM can be expressed in Fig. 1. This means that the HUHPM can rest on any type of network’s original growth way and RPA | FANG Jin-qing, BI Qiao, LI Yong, LU Xin-biao, LIU Qiang | 2007 | Annual Report of China Institute of Atomic Energy2007，，1： | 16 |
| 19 | Analysis of soft tissue sarcomas in 1118 cases显示文摘背景分析并且周期性地比较软组织肉瘤以便更新发生,临床的诊断,治疗,和进行中的研究是重要的。现在的学习被进行决定软织物肉瘤的每种类型的相对频率。在 1993 年 1 月和 2006 年 12 月之间对待的主要软织物肉瘤的 1118 个盒子全部的方法 A 在回顾的分析被评估。根据病理学的组织结果,有最高的比例的疾病是恶意的含纤维的 histiocytomas (35.24%) , synovial 肉瘤(17.08%) , liposarcomas (16.28%) ,和 rhabdomyosarcomas (12.61%) 。软织物肉瘤在每个年龄组被检测并且发生在身体的所有部分。盒子的数字多年以来逐渐地增加了。结论恶意的含纤维的 histiocytomas 在软织物肉瘤之中有最高的频率。盒子的数字多年以来逐渐地增加了。 | FANG Zhi-wei CHEN Jing TENG Sheng CHEN Yong XUE Rui-feng | 2009 | Chinese Medical Journal2009，，1： | 16 |
| 20 | Gait analysis of patients with knee osteoarthritis before and after Chinese massage treatment显示文摘The objective of this study was to evaluate the effectiveness of Chinese massage therapy in patients with knee osteoarthritis(OA) by measuring lower-limb gait parameters. We recruited 20 women with knee OA,who then underwent Chinese massage therapy three times per week for 2 weeks. The patients underwent gait evaluation using a six-camera infrared motion analysis system. They completed Western Ontario and Mc Master Universities Osteoarthritis Index questionnaires before and after treatment. We calculated the forward speed,step width,step length,total support time percentage,initial double support time percentage,and single support time percentage. We also measured the angles at the knee,hip,and ankle during the stance phase of walking. The results showed statistically significant mean differences in knee pain relief,alleviation of stiffness,and physical function enhancement after therapy(P < 0.05). The patients gained significantly faster gait speed,greater step width,and increased total support time percentage after the Chinese massage therapy(P < 0.05). There were no significant differences in the range of motion or initial contact angles of the knee,hip,or ankle during the stance phase of walking. We concluded that Chinese massage is a beneficial complementary treatment and an alternative therapy choice for patients with knee OA for short-term pain relief. Chinese massage may improve walking ability for these patients. | Zhu Qingguang Fang Min Gong Li Jiang Shuyun Sun Wuquan Li Jianhua Li Yong | 2015 | Journal of Traditional Chinese Medicine2015，35，4： | 16 |
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