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| 1 | A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01)显示文摘The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs. We report the complete genome sequence and comparative analysis of an isolate (BJ01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 2 ORFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS- associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to beinvolved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the Mprotein, which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides noevidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of otherpossible SARS-related pathogen(s). | QIN E'de ZHU Qingyu YU Man FAN Baochang CHANG Guohui SI Bingyin YANG Bao PENG Wenming JIANG Tao LIU Bohua DENG Yongqiang LIU Hong ZHANG Yu WANG Cui LI Yuquan GAN Yonghua LI Xiaoyu L Fushuang TAN Gang CAO Wuchun, YANG Ruifu Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, Beijing 100071, China WANG Jian, LI Wei, XU Zuyuan, LI Yan, WU Qingfa, LIN Wei, CHEN Weijun, TANG Lin, DENG Yajun, HAN Yujun, LI Changfeng, LEI Meng, LI Guoqing, LI Wenjie, L Hong, SHI Jianping, TONG Zongzhong, ZHANG Feng, LI Songgang, LIU Bin, LIU Siqi, DONG Wei, WANG Jun, Gane K-S Wong, YU Jun & YANG Huanming* Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300 National Center for Genome Information, Beijing 101300, China | 2003 | Chinese Science Bulletin2003，48，10： | 121 |
| 2 | Erianin,a novel dibenzyl compound in Dendrobium extract,inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis显示文摘Ferroptosis,a novel form of programmed cell death,is characterized by iron-dependent lipid peroxidation and has been shown to be involved in multiple diseases,including cancer.Stimulating ferroptosis in cancer cells may be a potential strategy for cancer therapy.Therefore,ferroptosis-inducing drugs are attracting more attention for cancer treatment.Here,we showed that erianin,a natural product isolated from Dendrobium chrysotoxum Lindl,exerted its anticancer activity by inducing cell death and inhibiting cell migration in lung cancer cells.Subsequently,we demonstrated for the first time that erianin induced ferroptotic cell death in lung cancer cells,which was accompanied by ROS accumulation,lipid peroxidation,and GSH depletion.The ferroptosis inhibitors Fer-1 and Lip-1 but not Z-VAD-FMK,CQ,or necrostatin-1 rescued erianin-induced cell death,indicating that ferroptosis contributed to erianin-induced cell death.Furthermore,we demonstrated that Ca^(2+)/CaM signaling was a critical mediator of erianin-induced ferroptosis and that blockade of this signaling significantly rescued cell death induced by erianin treatment by suppressing ferroptosis.Taken together,our data suggest that the natural product erianin exerts its anticancer effects by inducing Ca^(2+)/CaMdependent ferroptosis and inhibiting cell migration,and erianin will hopefully serve as a prospective compound for lung cancer treatment. | Peng Chen Qibiao Wu Jiao Feng Lili Yan Yitian Sun Shuiping Liu Yu Xiang Mingming Zhang Ting Pan Xiaying Chen Ting Duan Lijuan Zhai Bingtao Zhai Wengang Wang Ruonan Zhang Bi Chen Xuemeng Han Yicong Li Liuxi Chen Ying Liu Xingxing Huang Ting Jin Wenzheng Zhang Hong Luo Xiaohui Chen Yongqiang Li Qiujie Li Guohua Li Qin Zhang Lvjia Zhuo Zuyi Yang Huifen Tang Tian Xie Xiaoping Ouyang Xinbing Sui | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 42 |
| 3 | A review of mineral systems and associated tectonic settings of northern Xinjiang,NW China显示文摘在这份报纸我们在场在北 Xinjiang 的矿物质系统的评论, NW 中国,集中于 Tianshan,韦斯特和东方 Junggar 和 Altay orogenic 系上带子,所有哪个是更大的中央亚洲 Orogenic 带(CAOB ) 的部分。CAOB 是古老的 microcontinents,岛弧,海洋的 plateaux 和海洋的盘子的复杂大杂烩,它在早 Palaeozoic 被混合并且增大到早二叠的时间。CAOB 大杂烩的建立被罢工滑倒运动跟随并且由 intraplate magmatism 影响了,连接了到披风羽毛活动,最好由 250 个妈西伯利亚的陷井和 280 妈 Tarim 事件例示。在北 Xinjiang,有众多、经济地重要的矿物质系统。在这贡献,我们描述代表性的矿藏的一种选择,包括 subduction 相关的斑岩和 epithermal 沉积物, volcanogenic 巨大的硫醚和 skarn 系统。砍招待地区的 Au 矿脉可能是首先形成了在罢工滑倒期间侵入相关、随后重做变丑。Intraplate magmatism 导致了炮兵阵地同中心地 zoned (阿拉斯加人风格) maficultramafic 侵入,许多哪个主人 orthomagmatic 硫醚沉积物。在 Altay orogen 的伟晶岩的一条巨大的带,局部地招待世界级的稀罕金属沉积物。转动前面,招待沙岩的 U mineralisation 完成北 Xinjiang 岩层的富有的矿物质天赋。 | Franco Pirajno Reimar Seltmann Yongqiang Yang | 2011 | Geoscience Frontiers2011，2，2： | 39 |
| 4 | Characterizing the dynamics of soil organic carbon in grasslands on the Qinghai-Tibetan Plateau显示文摘Carbon dynamics of grasslands on the Qinghai-Tibetan Plateau may play an important role in regional and global carbon cycles. The CENTURY model (Version 4.5) is used to examine temporal and spatial variations of soil organic carbon (SOC) in grasslands on the Plateau for the period from 1960 to 2002. The model successfully simulates the dynamics of aboveground carbon and soil surface SOC at the soil depth of 0-20 cm and the simulated results agree well to the measurements. Examination of SOC for eight typical grasslands shows different patterns of temporal variation in different ecosystems in 1960-2002. The extent of temporal variation increases with the increase of SOC of ecosystem. SOC increases first and decreases quickly then during the period from 1990 to 2000. Spatially, SOC density obtained for the equilibrium condition declines gradually from the southeast to the northwest on the plateau and showed a high heterogeneity in the eastern plateau. The results suggest that (i) SOC den-sity in the alpine grasslands shows remarkable response to climate change during the 42 years, and (ii) the net carbon exchange rate between the alpine grassland ecosystems and the atmosphere increases from 1990 to 2000 as compared with that before 1990. | ZHANG YongQiang TANG YanHong JIANG Jie YANG YongHui | 2007 | Science China Earth Sciences2007，50，1： | 25 |
| 5 | Evolution characters of water exchange abilities between Dongting Lake and Yangtze River显示文摘在 19512010 在东廷·莱克和长江主流由使用相关控制的地调查水文学数据驻扎,在到从不同时间规模的三座峡水库( TGR )的操作的二水身体和他们的反应之间的水交换能力的进化字符基于他们的水力的关系被分析。结果如下被显示出。第一在 7 月 9 月期间,到东廷·莱克的三个插头的补充能力更强壮,并且在 1 月三月,到长江的东廷·莱克的补充能力更强壮。第二,在东廷·莱克和长江之间的水交换系数上有一个明显的内部十的波浪。在 19511958 和 19591968,到东廷·莱克的三个插头的补充能力更强壮,但是在 20032010,到长江的东廷·莱克的补充能力被加强了。第三,三个插头的喷洒部门能力变弱,并且来自三个插头的东廷·莱克的水在三座峡水库的操作以后在典型的年里或在 TGR 的不同派遣模式下面减少。而且,来自四条河的东廷·莱克的水拿主导的位置,它显然提高东廷·莱克的补充能力到长江。第四如果在盆的流量变化的效果没被考虑,交换能力和交换的进化人物在规模通常与在他们之间的水交换数量的变化被改变的不同时间在东廷·莱克和长江之间处理,尽管影响水的因素交换在他们之间的能力是很复杂的。在河湖水交换能力和河湖水交换之间有同轴的生长或衰落关系的这些表演总计。 | OU Chaomin LI Jingbao ZHOU Yongqiang CHENG Weiyan YANG Yan ZHAO Zhonghua | 2014 | Journal of Geographical Sciences2014，24，4： | 19 |
| 6 | Generation of RAG 1- and 2-deficient rabbits by embryo microinjection of TALENs显示文摘 | Jun Song Juan Zhong Xiaogang Guo Yongqiang Chen Qingjian zou Jiao Huang Xiaoping Li Quanjun Zhang Zhiwu Jiang Chengcheng Tang Huaqiang Yang Tao Liu Peng Li Duanqing Pei Liangxue Lai | 2013 | Cell Research2013，23，8： | 15 |
| 7 | Experimental study of an anti-icing method over an airfoil based on pulsed dielectric barrier discharge plasma显示文摘Aircraft icing has long been a plague to aviation for its serious threat to flight safety. Even though lots of methods for anti-icing have been in use or studied for quite a long time, new methods are still in great demand for both civil and military aircraft. The current study in this paper uses widely used Dielectric Barrier Discharge(DBD) plasma actuation to anti-ice on a NACA0012 airfoil model with a chord length of 53.5 cm in a closed-circuit icing wind tunnel. An actuator was installed at the leading edge of the airfoil model, and actuated by a pulsed low-temperature plasma power source. The actuator has two types of layout, a striped electrode layout and a meshy electrode layout.The ice accretion process or anti-icing process was recorded by a CCD camera and an infrared camera. Instantaneous pictures and infrared contours show that both types of DBD plasma actuators have the ability for anti-ice under a freestream velocity of 90 m/s, a static temperature of -7℃,an Median Volume droplet Diameter(MVD) of 20 lm, and an Liquid Water Content(LWC) of 0.5 g/m^3. The detected variations of temperatures with time at specific locations reveal that the temperatures oscillate for some time after spraying at first, and then tend to be nearly constant values.This shows that the key point of the anti-icing mechanism with DBD plasma actuation is to achieve a thermal equilibrium on the model surface. Besides, the power consumption in the anti-icing process was estimated in this paper by Lissajous figures measured by an oscilloscope, and it is lower than those of existing anti-icing methods. The experimental results presented in this paper indicate that the DBD plasma anti-icing method is a promising technique in the future. | Yongqiang TIAN Zhengke ZHANG Jinsheng CAI Leilei YANG Lei KANG | 2018 | Chinese Journal of Aeronautics2018，31，7： | 15 |
| 8 | The seasonal dependence of cycle slip occurrence of GPS data over China low latitude region显示文摘The relationship of daily accumulated cycle slip occurrence with the season is analyzed using the GPS data observed in six GPS stations located in China low latitude region in 2001. It is found that the seasonal dependence of cycle slip oc-currence is evident. The cycle slip mainly occurs during the periods of two equinox months (March to May and September to October), and some correlative changes of the cycle slip occurrences over all six stations are exhibited in some special days. Considering the diurnal dependence of cycle slip, it can be inferred that the cycle slip occurrence with certain elevation limitation is related with the iono-spheric irregularities over this region. | ZHANG DongHe FENG Man XIAO Zuo HAO YongQiang SHI LiQin YANG GuangLin SUO YuCheng | 2007 | Science China(Technological Sciences)2007，50，4： | 10 |
| 9 | LSD1 coordinates with the SIN3A/HDAC complex and maintains sensitivity to chemotherapy in breast cancer显示文摘 | Yang Yang Wei Huang Rongfang Qiu Ruiqiong Liu Yi Zeng Jie Gao Yu Zheng Yongqiang Hou Shuang Wang Wenqian Yu Shuai Leng Dandan Feng Yan Wang | 2018 | Journal of Molecular Cell Biology2018，10，4： | 10 |
| 10 | CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells显示文摘In face of the everlasting battle toward COVID-19 and the rapid evolution of SARS-CoV-2,no specific and effective drugs for treating this disease have been reported until today.Angiotensin-converting enzyme 2(ACE2),a receptor of SARS-CoV-2,mediates the virus infection by binding to spike protein.Although ACE2 is expressed in the lung,kidney,and intestine,its expressing levels are rather low,especially in the lung.Considering the great infectivity of COVID-19,we speculate that SARS-CoV-2 may depend on other routes to facilitate its infection.Here,we first discover an interaction between host cell receptor CD147 and SARS-CoV-2 spike protein.The loss of CD147 or blocking CD147 in Vero E6 and BEAS-2B cell lines by anti-CD147 antibody,Meplazumab,inhibits SARSCoV-2 amplification.Expression of human CD147 allows virus entry into non-susceptible BHK-21 cells,which can be neutralized by CD147 extracellular fragment.Viral loads are detectable in the lungs of human CD147(hCD147)mice infected with SARS-CoV-2,but not in those of virus-infected wild type mice.Interestingly,virions are observed in lymphocytes of lung tissue from a COVID-19 patient.Human T cells with a property of ACE2 natural deficiency can be infected with SARS-CoV-2 pseudovirus in a dosedependent manner,which is specifically inhibited by Meplazumab.Furthermore,CD147 mediates virus entering host cells by endocytosis.Together,our study reveals a novel virus entry route,CD147-spike protein,which provides an important target for developing specific and effective drug against COVID-19. | Ke Wang Wei Chen Zheng Zhang Yongqiang Deng Jian-Qi Lian Peng Du Ding Wei Yang Zhang Xiu-Xuan Sun Li Gong Xu Yang Lei He Lei Zhang Zhiwei Yang Jie-Jie Geng Ruo Chen Hai Zhang Bin Wang Yu-Meng Zhu Gang Nan Jian-Li Jiang Ling Li Jiao Wu Peng Lin Wan Huang Liangzhi Xie Zhao-Hui Zheng Kui Zhang Jin-Lin Miao Hong-Yong Cui Min Huang Jun Zhang Ling Fu Xiang-Min Yang Zhongpeng Zhao Shihui Sun Hongjing Gu Zhe Wang Chun-Fu Wang Yacheng Lu Ying-Ying Liu Qing-Yi Wang Huijie Bian Ping Zhu Zhi-Nan Chen | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 9 |
| 11 | LICOM Model Datasets for the CMIP6 Ocean Model Intercomparison Project显示文摘The datasets of two Ocean Model Intercomparison Project(OMIP)simulation experiments from the LASG/IAP Climate Ocean Model,version 3(LICOM3),forced by two different sets of atmospheric surface data,are described in this paper.The experiment forced by CORE-II(Co-ordinated Ocean–Ice Reference Experiments,Phase II)data(1948–2009)is called OMIP1,and that forced by JRA55-do(surface dataset for driving ocean–sea-ice models based on Japanese 55-year atmospheric reanalysis)data(1958–2018)is called OMIP2.First,the improvement of LICOM from CMIP5 to CMIP6 and the configurations of the two experiments are described.Second,the basic performances of the two experiments are validated using the climatological-mean and interannual time scales from observation.We find that the mean states,interannual variabilities,and long-term linear trends can be reproduced well by the two experiments.The differences between the two datasets are also discussed.Finally,the usage of these data is described.These datasets are helpful toward understanding the origin system bias of the fully coupled model. | Pengfei LIN Zhipeng YU Hailong LIU Yongqiang YU Yiwen LI Jirong JIANG Wei XUE Kangjun CHEN Qian YANG Bowen ZHAO Jilin WEI Mengrong DING Zhikuo SUN Yaqi WANG Yao MENG Weipeng ZHENG Jinfeng MA | 2020 | Advances in Atmospheric Sciences2020，37，3： | 9 |
| 12 | Interfacial adsorption-insertion mechanism induced by phase boundary toward better aqueous Zn-ion battery显示文摘Biphasic and multiphasic compounds have been well clarified to achieve extraordinary electrochemical properties as advanced energy storage materials.Yet the role of phase boundaries in improving the performance is remained to be illustrated.Herein,we reported the biphasic vanadate,that is,Na_(1.2)V_(3)O_(8)/K_(2)V_(6)O_(16)·1.5H_(2)O(designated as Na0.5K0.5VO),and detected the novel interfacial adsorption-insertion mechanism induced by phase boundaries.Firstprinciples calculations indicated that large amount of Zn^(2+)and H^(+)ions would be absorbed by the phase boundaries and most of them would insert into the host structure,which not only promote the specific capacity,but also effectively reduce diffusion energy barrier toward faster reaction kinetics.Driven by this advanced interfacial adsorption-insertion mechanism,the aqueous Zn/Na_(0.5)K_(0.5)VO is able to perform excellent rate capability as well as long-term cycling performance.A stable capacity of 267 mA h g^(-1)after 800 cycles at 5 A g^(-1)can be achieved.The discovery of this mechanism is beneficial to understand the performance enhancement mechanism of biphasic and multiphasic compounds as well as pave pathway for the strategic design of highperformance energy storage materials. | Lutong Shan Yiren Wang Shuquan Liang Boya Tang Yongqiang Yang Ziqing Wang Bingan Lu Jiang Zhou | 2021 | InfoMat2021，3，9： | 8 |
| 13 | Study on Biogenic Amines in Various Dry Salted Fish Consumed in China显示文摘This study was carried out to investigate the biogenic amines(BAs), physicochemical property and microorganisms in dry salted fish, a traditional aquatic food consumed in China. Forty three samples of dry salted fish were gathered from retail and wholesale markets and manufacturers, which had been produced in various regions in China. Cadaverine(CAD) and putrescine(PUT) were quantitatively the most common biogenic amines. About 14% of the samples exceeded the histamine content standards established by the FDA and/or EU. The highest histamine content was found in Silver pomfret(Pampus argenteus)(347.79 mg kg^(-1)). Five of forty three samples exceeded the acceptable content of TYR(100 mg kg^(-1)), and 23.26% of dried-salted fish contained high contents of biogenic amines(above 600 mg kg^(-1)). In addition, species, regions, pickling processes and drying methods made the physicochemical property, microorganisms and biogenic amines in dry salted fish to be different to some extents. The total plate count(TPC) was much higher than that of total halophilic bacteria in all samples. The biogenic amines, physicochemical property and microbiological counts exhibited large variations among samples. Furthermore, no significant correlation between biogenic amines and physicochemical property and TPC was observed. This study indicated that dry salted fish may still present healthy risk for BAs, depending on the processing methods, storage conditions among others. | WU Yanyan CHEN Yufeng LI Laihao YANG Xianqing YANG Shaoling LIN Wanling ZHAO Yongqiang DENG Jianchao | 2016 | Journal of Ocean University of China2016，15，4： | 8 |
| 14 | Experimental and analytical studies on multiple tuned mass dampers for seismic protection of porcelain electrical equipment显示文摘Porcelain electrical equipment(PEE),such as current transformers,is critical to power supply systems,but its seismic performance during past earthquakes has not been satisfactory.This paper studies the seismic performance of two typical types of PEE and proposes a damping method for PEE based on multiple tuned mass dampers(MTMD).An MTMD damping device involving three mass units,named a triple tuned mass damper(TTMD),is designed and manufactured.Through shake table tests and finite element analysis,the dynamic characteristics of the PEE are studied and the effectiveness of the MTMD damping method is verified.The adverse influence of MTMD redundant mass to damping efficiency is studied and relevant equations are derived.MTMD robustness is verified through adjusting TTMD control frequencies.The damping effectiveness of TTMD,when the peak ground acceleration far exceeds the design value,is studied.Both shake table tests and finite element analysis indicate that MTMD is effective and robust in attenuating PEE seismic responses.TTMD remains effective when the PGA far exceeds the design value and when control deviations are considered. | Bai Wen Dai Junwu Zhou Huimeng Yang Yongqiang Ning Xiaoqing | 2017 | Earthquake Engineering and Engineering Vibration2017，16，4： | 8 |
| 15 | Additively manufactured biodegradable porous magnesium implants for elimination of implant-related infections:An in vitro and in vivo study显示文摘Magnesium(Mg)alloys that have both antibacterial and osteogenic properties are suitable candidates for orthopedic implants.However,the fabrication of ideal Mg implants suitable for bone repair remains challenging because it requires implants with interconnected pore structures and personalized geometric shapes.In this study,we fabricated a porous 3D-printed Mg-Nd-Zn-Zr(denoted as JDBM)implant with suitable mechanical properties using selective laser melting technology.The 3D-printed JDBM implant exhibited cytocompatibility in MC3T3-E1 and RAW267.4 cells and excellent osteoinductivity in vitro.Furthermore,the implant demonstrated excellent antibacterial ratios of 90.0% and 92.1% for methicillin-resistant S.aureus(MRSA)and Escherichia coli,respectively.The 3D-printed JDBM implant prevented MRSA-induced implant-related infection in a rabbit model and showed good in vivo biocompatibility based on the results of histological evaluation,blood tests,and Mg2+deposition detection.In addition,enhanced inflammatory response and TNF-α secretion were observed at the bone-implant interface of the 3D-printed JDBM implants during the early implantation stage.The high Mg^(2+)environment produced by the degradation of 3D-printed JDBM implants could promote M1 phenotype of macrophages(Tnf,iNOS,Ccl3,Ccl4,Ccl5,Cxcl10,and Cxcl2),and enhance the phagocytic ability of macrophages.The enhanced immunoregulatory effect generated by relatively fast Mg^(2+)release and implant degradation during the early implantation stage is a potential antibacterial mechanism of Mg-based implant.Our findings indicate that 3D-printed porous JDBM implants,having both antibacterial property and osteoinductivity,hold potential for future orthopedic applications. | Kai Xie Nanqing Wang Yu Guo Shuang Zhao Jia Tan Lei Wang Guoyuan Li Junxiang Wu Yangzi Yang Wenyu Xu Juan Chen Wenbo Jiang Penghuai Fu Yongqiang Hao | 2022 | Bioactive Materials2022，7，2： | 8 |
| 16 | Coral community changes in response to a high sedimentation event:A case study in southern Hainan Island显示文摘A high sedimentation event caused by dredging and dumping of sediment was recorded on Xiaodonghai Reef in Yulin Bay,southern Hainan Island,China.Significantly high sedimentation and constant light shading were observed during the sediment dumping event(SD Event).Using long-term video transects,we quantified coral community changes and responses to the SD Event between 2008 and 2010.The SD Event caused severe coral mortality on Xiaodonghai Reef at a depth of 6 m,while corals at 3 m were less affected.Total live coral cover at 6 m decreased from 54.3% to 14.8%,and Diploastrea heliopora replaced Galaxea fascicularis as the dominant coral species at 6 and 9 m.The density of juvenile corals also declined after the SD Event,especially for the genera Galaxea and Platygyra.However,the density of juvenile Porites and Pocillopora spp.slightly increased.Monitoring for 11 months after the SD Event indicated no recovery of coral communities on Xiaodonghai Reef.Long-term video transect data also revealed that mean live coral cover dramatically declined,from 30.5% in 2008 to 9% in 2010,while the dominant corals in Yulin Bay shifted to more tolerant coral species,such as massive Porites spp.and D.heliopora.The rapid coral community degradation in Yulin Bay between 2008 and 2010 was probably caused by high sediment deposition resulting from intensive dredging and land-clearing activities.These results highlight the necessity for an integrated watershed management to control sediment deposition on near-shore coral reefs. | LI XiuBao HUANG Hui LIAN JianSheng YANG JianHui YE Cheng CHEN YongQiang HUANG LiangMin | 2013 | Chinese Science Bulletin2013，58，9： | 7 |
| 17 | Additive manufacturing of steel–copper functionally graded material with ultrahigh bonding strength显示文摘Additive manufacturing enables processing of functionally graded materials(FGMs)with flexible spatial design and high bonding strength.A steel-copper FGM with high interfacial strength was developed using laser powder bed fusion(LPBF).The effect of laser process parameters on interfacial defects was evaluated by X-ray tomography,which indicates a low porosity level of 0.042%therein.Gradient/fine dendritic grains in the interface are incited by high cooling rates,which facilitates interface strengthening.Multiple mechanical tests evaluate the bonding reliability of interface;and the fatigue tests further substantiate the ultrahigh bonding strength in FGMs,which is superior to traditional manufacturing methods.Mechanisms of the high interfacial bond strength were also discussed. | Chaolin Tan Youxiang Chew Guijun Bi Di Wang Wenyou Ma Yongqiang Yang Kesong Zhou | 2021 | Journal of Materials Science & Technology2021，，13： | 7 |
| 18 | CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta,alpha,beta,and gamma显示文摘SARS-CoV-2 mutations contribute to increased viral transmissibility and immune escape,compromising the effectiveness of existing vaccines and neutralizing antibodies.An in-depth investigation on COVID-19 pathogenesis is urgently needed to develop a strategy against SARS-CoV-2 variants.Here,we identified CD147 as a universal receptor for SARS-CoV-2 and its variants.Meanwhile,Meplazeumab,a humanized anti-CD147 antibody,could block cellular entry of SARS-CoV-2 and its variants-alpha,beta,gamma,and delta,with inhibition rates of 68.7,75.7,52.1,52.1,and 62.3%at 60μg/ml,respectively.Furthermore,humanized CD147 transgenic mice were susceptible to SARS-CoV-2 and its two variants,alpha and beta.When infected,these mice developed exudative alveolar pneumonia,featured by immune responses involving alveoli-infiltrated macrophages,neutrophils,and lymphocytes and activation of IL-17 signaling pathway.Mechanistically,we proposed that severe COVID-19-related cytokine storm is induced by a'spike protein-CD147-CyPA signaling axis':Infection of SARS-CoV-2 through CD147 initiated the JAK-STAT pathway,which further induced expression of cyclophilin A(CyPA);CyPA reciprocally bound to CD147 and triggered MAPK pathway.Consequently,the MAPK pathway regulated the expression of cytokines and chemokines,which promoted the development of cytokine storm.Importantly,Meplazumab could effectively inhibit viral entry and inflammation caused by SARS-CoV-2 and its variants.Therefore,our findings provided a new perspective for severe COVID-19-related pathogenesis.Furthermore,the validated universal receptor for SARS-CoV-2 and its variants can be targeted for COVID-19 treatment. | Jiejie Geng Liang Chen Yufeng Yuan Ke Wang Youchun Wang Chuan Qin Guizhen Wu Ruo Chen Zheng Zhang Ding Wei Peng Du Jun Zhang Peng Lin Kui Zhang Yongqiang Deng Ke Xu Jiangning Liu Xiuxuan Sun Ting Guo Xu Yang Jiao Wu Jianli Jiang Ling Li Kun Zhang Zhe Wang Jing Zhang Qingguo Yan Hua Zhu Zhaohui Zheng Jinlin Miao Xianghui Fu Fengfan Yang Xiaochun Chen Hao Tang Yang Zhang Ying Shi Yumeng Zhu Zhuo Pei Fei Huo Xue Liang Yatao Wang Qingyi Wang Wen Xie Yirong Li Mingyan Shi Huijie Bian Ping Zhu Zhi-Nan Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 6 |
| 19 | Variations of energy metabolism and adenosine Triphosphatase activity in gastric mucosa in chronic atrophic gastritis rats with Qi deficiency and blood stasis syndrome and effect of Zhiweifangbian capsule显示文摘OBJECTIVE: To study the effects of Zhiweifangbian (ZWFB) capsule on lactic dehydrogenase (LDH), succinic dehydrogenase (SDH) and ATPase activities in gastric mucosa of chronic atrophic gastritis (CAG) rats with Qi deficiency and blood stasis syndrome. METHODS: Totally 90 rats were randomly divided into 2 groups: normal group (n=10) and modelgroup (n=80). The CAG rat model of Qi deficiency and blood stasis type was induced by synthetic methods. After modeling for 12 weeks and the successful CAG model was determined, the CAG model rats were divided by random number table into model group (MG), ZWFB high-dose group (ZWFBH), ZWFB middle-dose group (ZWFBM), ZWFB low-dose group (ZWFBL) and Weimeisu group (WM), 9 rats in each group. The rats in the normal and model groups were intragastrically administrated with distilled water, 10 mL/kg every day; the ZWFB high-dose group with ZWFB, 0.6 g/ kg -1 · d -1 ; the ZWFB middle-dose group with ZWFB, 0.3 g/kg -1 · d -1 ; the ZWFB low-dose group with ZWFB, 0.15 g/kg -1 · d -1 , and the WM group with suspension of WM , 0.25 g/kg -1 · d -1 . The treatment was given for 90 consecutive days. Then general survival states were observed and the activities of LDH, SDH, Na + -K + -ATPase and Ca 2+ -Mg 2+ -ATPase in gastric mucosa tissue were detected. RESULTS: Compared with the normal group, activity of LDH in the gastric mucosa (P<0.05) and activities of SDH, Na + -K + -ATPase and Ca 2+ -Mg 2+ -ATPase significantly decreased in the normal group (P<0.05). Compared with the model group the activity of LDH decreased and activities of SDH, Na + -K + -ATPase and Ca 2+ -Mg 2+ -ATPase significantly increased in the high dose ZWFB group (P<0.05). CONCLUSION: ZWFB capsule can promote energy metabolism and ATPase activity in the gastric mucosa cell, so as to protect the function of the gastric mucosa cell. | Yongqiang Duan Weidong Cheng Yingxia Cheng Hongyan Li Xueyan Li Liming Zhu Xiaoyi Yang | 2013 | Journal of Traditional Chinese Medicine2013，33，4： | 6 |
| 20 | Assessment of potential soybean cadmium excluder cultivars at different concentrations of Cd in soils显示文摘The selection of cadmium-excluding cultivars has been used to minimize the transfer of cadmium into the human food chain. In this experiment, five Chinese soybean plants were grown in three soils with different concentrations of Cd(0.15, 0.75 and 1.12 mg/kg).Variations in uptake, enrichment, and translocation of Cd among these soybean cultivars were studied. The results indicated that the concentration of Cd in seeds that grew at1.12 mg/kg Cd in soils exceeded the permitted maximum levels in soybeans. Therefore, our results indicated that even some soybean cultivars grown on soils with permitted levels of Cd might accumulate higher concentrations of Cd in seeds that are hazardous to human health. The seeds of these five cultivars were further assessed for interactions between Cd and other mineral nutrient elements such as Ca, Cu, Fe, Mg, Mn and Zn. High Cd concentration in soil was found to inhibit the uptake of Mn. Furthermore, Fe and Zn accumulations were found to be enhanced in the seeds of all of the five soybean cultivars in response to high Cd concentration. Cultivar Tiefeng 31 was found to fit the criteria for a Cd-excluding cultivar under different concentrations of Cd in soils. | Yang Zhi Kangxin He Ting Sun Yongqiang Zhu Qixing Zhou | 2015 | Journal of Environmental Sciences2015，27，9： | 6 |
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