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| 1 | Surgical spacer placement and proton radiotherapy for unresectable hepatocellular carcinoma显示文摘Few potentially curative treatment options exist apart from hepatic resection for patients with huge hepatocellular carcinoma (HCC). Proton radiotherapy is a promising new modality which has an inherent antitumor effect against HCC. However, the application of proton radiotherapy for tumors adjacent to the gastrointestinal tract is restricted because the tolerance dose of the intestine is extremely low. A novel two-step treatment was developed with surgical spacer placement and subsequent proton radiotherapy to administer proton radiotherapy with curative intent. This report presents a case of a patient with a huge unresectable HCC treated by this method who achieved disease-free survival of more than 2 years. This new strategy may potentially be an innovative and standard therapy for unresectable HCC in the near future. | Shohei Komatsu Yuichi Hori Takumi Fukumoto Masao Murakami Yoshio Hishikawa Yonson Ku | 2010 | World Journal of Gastroenterology2010，16，14： | 5 |
| 2 | 多重稳固的胰腺的 hamartomas : 一份案例报告和文学的评论显示文摘 Non-neoplastic tumor-like lesions in the pancreas are uncommon.Here,we present a case of multiple solid pancreatic hamartomas in a 78-year-old Japanese woman.Her computed tomography revealed a pancreatic mass,measuring 1.8 cm in maximum diameter.However,no symptoms were found.She was not an alcoholic and had no history of pancreatitis.The patient underwent a pancreatoduodenectomy,and three well-demarcated solid nodules measuring 1.7 cm,0.4 cm,and 0.3 cm in diameter were found in the pancreatic head.Microscopically,the lesions were composed of non-neoplastic,disarranged acinar cells and ducts embedded in a sclerotic stroma with elongated spindle cells that lacked discrete islets.The stromal spindle cells were immunoreactive for CD34 and CD117.The histological diagnosis was multiple solid hamartomas of the pancreas.There has been no recurrence 30 mo after surgery.So far,18 cases of pancreatic hamartoma have been reported in the English literature,including our case.Six out of these 18 cases seemed to fit the criteria of solid pancreatic hamartoma.Although the number of cases was limited,solid pancreatic hamartomas seem to be benign tumor-like lesions,which are found incidentally in healthy middle-aged adults,but occasionally involve the whole pancreas,resulting in a poor prognosis.Solid pancreatic hamartoma was sometimes associated with minor pancreatic abnormality,and multiple small lesions other than the main tumors were detected in a small number of cases.From these findings,one may speculate that solid pancreatic hamartoma could be the result of a malformation during the development of the pancreas. | Fumi Kawakami Michio Shimizu Hiroshi Yamaguchi Shigeo Hara Ippei Matsumoto Yonson Ku Tomoo Itoh | 2012 | World Journal of Gastrointestinal Oncology2012，4，9： | 5 |
| 3 | Two-stage treatment with hepatectomy and carbon-ion radiotherapy for multiple hepatic epithelioid hemangioendotheliomas显示文摘Hepatic epithelioid hemangioendothelioma(HEH)is a rare neoplasm of vascular origin with variable malignant potential.Because most patients with this condition have multiple bilobar lesions,liver transplantation is the standard treatment,and hepatectomy is much less frequently indicated.We describe a case of a 35-yearold woman with unresectable multiple bilobar HEH successfully treated by combination treatment with hepatectomy and carbon-ion radiotherapy.This case is very meaningful since it demonstrated the effectiveness of carbon-ion radiotherapy for HEH and the possibility of expanding the curative treatment options for multiple bilobar hepatic tumors. | Shohei Komatsu Takeshi Iwasaki Yusuke Demizu Kazuki Terashima Osamu Fujii Atsushi Takebe Akihiro Toyokawa Kazuhiro Teramura Takumi Fukumoto Yonson Ku Nobukazu Fuwa | 2014 | World Journal of Gastroenterology2014，20，26： | 2 |
| 4 | Evidence‐based C linical P ractice G uidelines for H epatocellular C arcinoma: The J apan S ociety of H epatology 2013 update (3rd JSH‐HCC G uidelines)显示文摘 | Norihiro Kokudo Kiyoshi Hasegawa Masaaki Akahane Hiroshi Igaki Namiki Izumi Takafumi Ichida Shinji Uemoto Shuichi Kaneko Seiji Kawasaki Yonson Ku Masatoshi Kudo Shoji Kubo Tadatoshi Takayama Ryosuke Tateishi Takashi Fukuda Osamu Matsui Yutaka Matsuyama Ta | 2015 | Hepatol Res2015，，2： | 2 |
| 5 | Clinical results and risk factors of proton and carbon ion therapy for hepatocellular carcinoma显示文摘 | Shohei Komatsu Takumi Fukumoto Yusuke Demizu Daisuke Miyawaki Kazuki Terashima Ryohei Sasaki Yuichi Hori Yoshio Hishikawa Yonson Ku Masao Murakami | 2011 | Cancer2011，，21： | 2 |
| 6 | Superselective transarterial chemoembolization for hepatocellular carcinoma. Validation of treatment algorithm proposed by Japanese guidelines显示文摘 | Kenichi Takayasu Shigeki Arii Masatoshi Kudo Takafumi Ichida Osamu Matsui Namiki Izumi Yutaka Matsuyama Michiie Sakamoto Osamu Nakashima Yonson Ku Norihiro Kokudo Masatoshi Makuuchi | 2011 | Journal of Hepatology2011，，4： | 2 |
| 7 | Corrigendum to: “Comparison of resection and ablation for hepatocellular carcinoma: A cohort study based on a Japanese nationwide survey” [J Hepatol 2013;58:724–729]显示文摘 | Kiyoshi Hasegawa Norihiro Kokudo Masatoshi Makuuchi Namiki Izumi Takafumi Ichida Masatoshi Kudo Yonson Ku Michiie Sakamoto Osamu Nakashima Osamu Matsui Yutaka Matsuyama | 2013 | Journal of Hepatology2013，，： | 2 |
| 8 | Carcinosarcoma of the gallbladder with chondroid differentiation显示文摘 | Tetsuo Ajiki Takeshi Nakamura Yasuhiro Fujino Yasuyuki Suzuki Yoshifumi Takeyama Yonson Ku Yoshikazu Kuroda Chiho Ohbayashi | 2002 | Journal of Gastroenterology2002，，11： | 1 |
| 9 | Resection of gallbladder cancer with hepatic metastasis after chemotherapy with gemcitabine显示文摘 | Haruki Morimoto Tetsuo Ajiki Shiro Takase Tsunenori Fujita Taku Matsumoto Yoshiyasu Mita Ippei Matsumoto Yasuhiro Fujino Yasuyuki Suzuki Yoshikazu Kuroda Yonson Ku | 2008 | Journal of Hepato-Biliary-Pancreatic Surgery2008，，6： | 1 |
| 10 | Comparison of resection and ablation for hepatocellular carcinoma: A cohort study based on a Japanese nationwide survey显示文摘 | Kiyoshi Hasegawa Norihiro Kokudo Masatoshi Makuuchi Namiki Izumi Takafumi Ichida Masatoshi Kudo Yonson Ku Michiie Sakamoto Osamu Nakashima Osamu Matsui Yutaka Matsuyama | 2012 | Journal of Hepatology2012，，： | 1 |
| 11 | The role of autophagy in the treatment of pancreatic cancer with gemcitabineand ionizing radiation显示文摘 | Hideyo Mukubou Toshiaki Tsujimura Ryohei Sasaki Yonson Ku | 2010 | International Journal of Oncology2010，，4： | 1 |
| 12 | A phase I/II study of gemcitabine-concurrent proton radiotherapy for locally advanced pancreatic cancer without distant metastasis显示文摘 | Kazuki Terashima Yusuke Demizu Naoki Hashimoto Dongcun Jin Masayuki Mima Osamu Fujii Yasue Niwa Kento Takatori Naoto Kitajima Sachiyo Sirakawa Ku Yonson Yoshio Hishikawa Mitsuyuki Abe Ryohei Sasaki Kazuro Sugimura Masao Murakami | 2012 | Radiotherapy and Oncology2012，，1： | 1 |
| 13 | Quantification of Pregenomic RNA and Covalently Closed Circular DNA in Hepatitis B Virus-Related Hepatocellular Carcinoma显示文摘 | Fugui Bai Yoshihiko Yano Takumi Fukumoto Atsushi Takebe Motofumi Tanaka Kaori Kuramitsu Nungki Anggorowati Hanggoro Tri Rinonce Dewiyani Indah Widasari Masaya Saito Hirotaka Hirano Takanobu Hayakumo Yasushi Seo Takeshi Azuma Yonson Ku Yoshitake Hayashi Da | 2013 | International Journal of Hepatology2013，，： | 1 |
| 14 | Plasma tissue factor pathway inhibitor levels in patients with acute pancreatitis显示文摘 | Takeo Yasuda Takashi Ueda Keiko Kamei Wataru Shinzaki Hidehiro Sawa Makoto Shinzeki Yonson Ku Yoshifumi Takeyama | 2009 | Journal of Gastroenterology2009，，10： | 1 |
| 15 | Role of Intraoperative Cholangiography in Patients Whose Biliary Tree Was Evaluated Preoperatively by Magnetic Resonance Cholangiopancreatography显示文摘 | Kimihiko Ueno Tetsuo Ajiki Hidehiro Sawa Ippei Matsumoto Takumi Fukumoto Yonson Ku | 2012 | World Journal of Surgery2012，，11： | 1 |
| 16 | Percutaneous Pelvic Perfusion with Extracorporeal Chemofiltration for Advanced Uterine Cervical Carcinoma显示文摘 | Takeshi Maruo Satoru Motoyama Shinya Hamana Shigeki Yoshida Noriyuki Ohara Mineo Yamasaki Yonson Ku | 2008 | Surgical Oncology Clinics of North America2008，，4： | 1 |
| 17 | Utility of the new Japanese severity score and indications for special therapies in acute pancreatitis显示文摘 | Takashi Ueda Yoshifumi Takeyama Takeo Yasuda Keiko Kamei Shumpei Satoi Hidehiro Sawa Makoto Shinzeki Yonson Ku Yoshikazu Kuroda Harumasa Ohyanagi | 2009 | Journal of Gastroenterology2009，，5： | 1 |
| 18 | Immunohistochemically Detected Expression of p27Kip1 and Skp2 Predicts Survival in Patients with Intrahepatic Cholangiocarcinomas显示文摘 | Nozomi Hashimoto MD Shinichi Yachida MD Keiichi Okano MD Hisao Wakabayashi MD Katsumi Imaida MD Kazutaka Kurokohchi MD Tsutomu Masaki MD Hisoka Kinoshita MD Masahiro Tominaga MD Tetsuo Ajiki MD Yonson Ku MD Takehiro Okabayashi MD Kazuhiro Hanazaki MD Mako | 2009 | Annals of Surgical Oncology2009，，2： | 1 |
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