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| 1 | 8.2ka BP冷气候事件确实在中国发生过吗?显示文摘综合迄今中国境内湖泊沉积、冰心、泥炭、石笋、古土壤和洪积物获得的全新世数据及序列表明,早全新世气候变化是不稳定的,至少存在一次明显的降温事件,且表现为区域差异,其根本原因是受不同气候系统、复杂地形(特别是高原)的制约。但是,将不同地区、存在于9.0~7.6ka BP期间、500a至200a不等的气候突变或波动和记录与环北大西洋的8.2ka BP气候突变事件相对应,并归因于Laurentide冰盖的崩塌冰融水注入北大西洋造成的降温显然是草率的。中国主要地处季风气候区,加上目前我们所得序列的不同年代、样品精度、不同材料以及缺乏对气候事件前后精确的年代数据的控制,对于中国是否存在相同的或相似的气候降温事件是值得商榷的。如果真的存在,其时间跨度、降温幅度以及诱发机制又是什么,均需进一步认真研究。 | 金章东 Jimin YU 吴艳宏 王苏民 | 2007 | 地质论评2007，53，5： | 11 |
| 2 | Outcome of Stretta radiofrequency and fundoplication for GERD- related severe asthmatic symptoms显示文摘这研究试图与 Stretta radiofrequency (SRF ) 或 laparoscopic 尼森式小屋 fundoplication (LNF ) 调查治疗的结果。137 gastroesophageal 倒流疾病(GERD ) 的一个总数为气喘对医疗不充分地作出回应的有严重气喘的症状的病人被调查。病人在 SRF 以后在 1 年和 5 年上面被跟随(n = 82 ) 或 LNF (n = 55 ) 治疗。盖住 29 的一张问询表联系了症状,药使用被采用。消化,呼吸,并且 ear-nose-throat (ENT ) 症状分数显著地在 antireflux 治疗以后减少了。症状分数分别地从 17.2 敲獳癩? 晥敦瑣 ? 潰獳扩祬戠 ? 湩捡楴慶楴杮琠敨 ? 慣整楮 ? 变化了 ???? 湡 ???? 瑫猠杩慮楬杮瀠瑡睨祡? 牯戠 ? 污整楲杮? 慣整楮 ?? 慣桤牥湩洭摥慩整 ? 散汬' 獩 D? 摡敨楳湯椠 ? 牢慥瑳挠湡散 ?散汬s 吗? | Zhiwei Hu Jimin Wu Zhonggao Wang Yu Zhang Weitao Liang Chao Yan | 2015 | Frontiers of Medicine2015，9，4： | 10 |
| 3 | A reconnaissance of Cu isotopic compositions of hydrothermal vein-type copper deposit, Jinman, Yunnan, China显示文摘The Jinman deposit is a low-temperature hydrothermal vein-type copper deposit, which occurs along faults and fractures within Middle Jurassic sandstone and mudstone units of the Lanping-Simao Mesozoic-Cenozoic basin of Yunnan Province. In this note, we report for the first time the Cu isotopic compositions of Cu-sulfides from the Jinman deposit. The data show large variations and low δ65Cu values of -3.70‰ to +0.30‰, which are in sharp con-trast to the δ65Cu values of high-temperature mag-matic-hydrothermal copper deposits (-0.62‰ to +0.40‰) and the modern ocean-floor massive sulfide deposits (-0.48‰ to +1.15‰). It is suggested that the Cu isotope fractionation at Jinman is affected mainly by the following factors, i.e. a low temperature of ore formation (150-286℃); a sedimen-tary source for ore materials; various stages of ore deposition; and involvement of organic matter in the ore-forming proc-esses. | JIANG Shaoyong Jon Woodhead YU Jimin PAN Jiayong LIAO Oiling WU Nanping | 2002 | Chinese Science Bulletin2002，47，3： | 9 |
| 4 | The internalization pathway,metabolic fate and biological effect of superparamagnetic iron oxide nanoparticles in the macrophage-like RAW264.7 cell显示文摘The potential applications of superparamagnetic iron oxide nanoparticles (SPIONs) in several nanomedical fields have attracted intense interest based on the cell-nano interaction. However, the mechanisms underlying cell uptake, the intracellular trail, final fate and the biological effects of SPIONs have not yet been clearly elucidated. Here, we showed that multiple endocytic pathways were involved in the internalization process of SPIONs in the RAW264.7 macrophage. The internalized SPIONs were biocompatible and used three different metabolic pathways: The SPIONs were distributed to daughter cells during mitosis; they were degraded in the lysosome and free iron was released into the intracellular iron metabolic pool; and, the intact SPIONs were potentially exocytosed out of the cells. The internalized SPIONs did not induce cell damage but affected iron metabolism, inducing the upregulation of ferritin light chain at both the mRNA and protein levels and ferroportin 1 at the mRNA level. These results may contribute to the development of nanobiology and to the safe use of SPIONs in medicine when administered as a contrast medium or a drug delivery tool. | GU JingLi XU HaiFei HAN YeHua DAI Wei HAO Wei WANG Chun Yu GU Ning XU HaiYan CAO JiMin | 2011 | Science China(Life Sciences)2011，54，9： | 8 |
| 5 | Chronology of environmental events over East Asia during the past 130 ka显示文摘In the transitional region between the Loess Plateau and deserts, 4 sections located respectively at Yuling, Hengshan, Dingbian and Huining of China are studied. The high-resolution paleoclimatic records obtained show that environmental events on varying time scales have happened over East Asia. These events are dated with the time scales established using the recently-developed approach of Automatic Orbital Tuning. This leads to the establishment of the chronology of the environmental events. | Zhongli Ding Jimin Sun Zhiwei Yu Dongsheng Liu | 1998 | Chinese Science Bulletin1998，43，21： | 6 |
| 6 | Efficient lung cancer-targeted drug delivery via a nanoparticle/MSC system显示文摘Low targeting efficiency limits the applications of nanoparticles in cancer therapy. The fact that mesenchymal stem cells(MSC) trapped in the lung after systemic infusion is a disadvantage for cell therapy purposes. Here, we utilized MSC as lung cancer-targeted drug delivery vehicles by loading nanoparticles(NP)with anti-cancer drug. MSC showed a higher drug intake capacity than fibroblasts. In addition, MSC showed predominant lung trapping in both rabbit and monkey. IR-780 dye, a fluorescent probe used to represent docetaxel(DTX) in NP, delivered via MSC accumulated in the lung. Both in vitro MSC/A549 cell experiments and in vivo MSC/lung cancer experiments validated the intercellular transportation of NP between MSC and cancer cells. In vivo assays showed that the MSC/NP/DTX drug delivery system exerted primary tumor inhibition efficiency similar to that of a NP/DTX drug system. Collectively, the MSC/NP drug delivery system is promising for lung-targeted drug delivery for the treatment of lung cancer and other lung-related diseases. | Xusheng Wang Haiyan Chen Xiaowei Zeng Wenpeng Guo Yu Jin Shan Wang Ruiyun Tian Yanjiang Han Ling Guo Jimin Han Yaojiong Wu Lin Mei | 2019 | Acta Pharmaceutica Sinica B2019，9，1： | 4 |
| 7 | First results on ^(76)Ge neutrinoless double beta decay from CDEX-1 experiment显示文摘We report the first results on ^(76)Ge neutrinoless double beta decay from stage one of the China dark-matter experiment(CDEX).A p-type point-contact high-purity germanium detector with a mass of 994 g has been installed to detect neutrinoless double beta decay events, as well as to directly detect dark matter particles. An exposure of 304 kg d has been analyzed over a wide spectral band from 500 keV to 3 MeV. The average event rate obtained was about 0.012 counts per keV per kg per day over the 2.039 MeV energy range. The half-life of ^(76)Ge neutrinoless double beta decay derived based on this result is T^(0ν)1/2>6.4×10^(22) yr(90% C.L.). An upper limit on the effective Majorana-neutrino mass of 5.0 eV has been achieved. | Li Wang Qian Yue KeJun Kang JianPing Cheng YuanJing Li TszKing Henry Wong ShinTed Lin JianPing Chang JingHan Chen QingHao Chen YunHua Chen Zhi Deng Qiang Du Hui Gong Li He QingJu He JinWei Hu HanXiong Huang TengRui Huang LiPing Jia Hao Jiang HauBin Li Hong Li JianMin Li Jin Li Jun Li Xia Li XueQian Li YuLan Li FongKay Lin ShuKui Liu Hao Ma JingLu Ma XingYu Pan Jie Ren XiChao Ruan ManBin Shen Vivek Sharma Lakhwinder Singh Manoj Kumar Singh Manoj Kumar Singh Arun Kumar Soma ChangJian Tang WeiYou Tang ChaoHsiung Tseng JiMin Wang Qing Wang ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue LiTao Yang SongWei Yang Nan Yi ChunXu Yu HaiJun Yu WeiHe Zeng XiongHui Zeng Zhi Zeng Lan Zhang YunHua Zhang MingGang Zhao Wei Zhao JiFang Zhou ZuYing Zhou JingJun Zhu WeiBin Zhu ZhongHua Zhu | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，7： | 3 |
| 8 | Theoretical Mechanistic Studies of Rh-Catalyzed c(sp^3)-H Amination:A Comparison with Co Analogue and Metal Effects显示文摘of main observation and conclusion The mechanism of Rh-catalyzed C(sp^3)—H amination has been computationally investigated.The reaction mechanism mainly involves sequential C(sp^3)—H activation,decarboxylation,nitrene migration insertion,and protonation steps.Competitive concerted metalation deprotonation(CMD)and external base assisted deprotonation(EBAD)pathways are found for the involved C(sp^3)—H activation in both Rh and Co analogous systems.This is different from the previously reported C(sp^2)—H activation,where the CMD is dominant.The key mechanistic difference between the two systems is found to be in the C(sp^3)—H activation step.In comparison with Rh species,the lower activity of Co complex toward the C(sp^3)—H activation could be ascribed to smaller atomic size of Co and thus larger steric repulsion between ancillary ligand and substrate along with the CMD pathway.In view of the EBAD pathway,however,the lower activity of Co species could be imputed to the triplet nature of Co center,which is against the electron transfer from the electron-rich carbon atom of the deprotonating C(sp^3)—H bond to the Co center.As to the subsequent decarboxylation and nitrene insertion steps,compared with the Co system,the relatively lower reactivity of Rh species is partially due to the stronger Rh—N bond,and the higher Ti(Rh—N)and n^*(Rh—N)orbital energies of the corresponding transition state structure. | Yang Yu Gen Luo Jimin Yang Yi Luo | 2020 | Chinese Journal of Chemistry2020，38，12： | 2 |
| 9 | Medical Additive Manufacturing: From a Frontier Technology to the Research and Development of Products显示文摘1.Research and development(R&D)and the challenges of raw materials for medical additive manufacturing Raw materials for medical additive manufacturing have a wide range of commonalities that are also seen in many other fields,making them an important basis in the field of three-dimensional(3D)printing.Problems and challenges related to material types,powder properties,formability,viscoelasticity,and so forth also share common features.For example,many metal materials are used in the field of aviation,while metals,polymers,and inorganic materials are used in the field of biomedicine.The most widely used materials in biomedicine are biocompatible.Various homogeneous and non-homogeneous composites are also available for 3D printing,and impose an additional challenge in additive manufacturing;the use of heterogeneous composites in 3D printing is particularly challenging. | Guixing Qiu Wenjiang Ding Wei Tian Ling Qin Yu Zhao Lianmeng Zhang Jian Lu Daijie Chen Guangyi Yuan Chengtie Wu Bingheng Lu Ruxu Du Jimin Chen Mo Elbestawi Zhongwei Gu Dichen Li Wei Sun Yuanjin Zhao Jie He Dadi Jin Bin Liu Kai Zhang Jianmo Li Kam WLeong Dewei Zhao Dingjun Hao Yingfang Ao Xuliang Deng Huilin Yang ShaoKeh Hsu Yingqi Chen Long Li Jianping Fan Guohui Nie Yun Chen Hui Zeng Wei Chen Yuxiao Lai | 2020 | Engineering2020，6，11： | 1 |
| 10 | Short-term responses of an alpine meadow community to removal of a dominant species along a fertilization gradient显示文摘Aims The relationship between biodiversity and ecosystem functioning has intrigued ecologists for several decades,but the effect of loss of a dominant species on community structure and functioning along a nutrient gradient remains poorly understood.The aim of this paper was to test the effect of a dominant species on community structure and function by conducting a species removal experiment along a fertilization gradient.Methods We removed the population of a dominant species(Elymus nutans)in a long-term fertilization field in an alpine meadow on the Tibetan Plateau,China.univariate general linear models were used to evaluate the effects of fertilization and removal on above-ground vegetation characteristics,including photosynthetically active radiation in the understory,species richness,shannon-Weiner diversity index,simpson’s dominance index,above-ground biomass(includ-ing different functional groups)and seedling richness and density.Important Findingsresults revealed that after two plant growing seasons,there was no significant effect of the removal of a dominant species on species richness and diversity of the remaining vegetation,but the biomass of forbs and seedling recruitment were significantly increased indicative of the potential for long-term effects.moreover,removal had a large effect at high fertilization levels,but little effect when fertilization levels were low.our studies indicated that community response to loss of a dominant species was mainly dependent on resource availability and the remaining functional group identities.We also found seedling recruitment was usually more sensitive to the influence of competition of dominant species than the estab-lished vegetation in the short term. | Wei Li Jimin Cheng Kailiang Yu Howard E.Epstein Guozhen Du | 2015 | Journal of Plant Ecology2015，8，5： | 1 |
| 11 | Synaptobrevin-2 facilitates the trafficking and function of atrial SK2 channel显示文摘Dear Editor,Small conductance Ca2+-activated potassium (SK) channels are widely expressed in various tissues and play a unique role in regulating cell function by integrating cytosolic Ca2+ levels and membrane potential (Adelman et al., 2012). Xu et al. first identified SK channels in the heart and found that SK channels, particularly the SK2 channel, are preferentially expressed in human and mouse atrial myocytes but not in ventricular myocytes (Xu et al., 2003). This suggests that the | Tao Li Xuehui Fan Yiyan Yu Linlin Chen Wenjun Huang Yan Yang Jimin Cao Xiaorong Zeng Xiaoqiu Tan | 2018 | Science China(Life Sciences)2018，61，5： | 1 |
| 12 | Distribution of polycyclic aromatic hydrocarbons insurface water and sediment near a drinking waterreservoir in Northeastern China 显示文摘 | LIU Yu SHEN Jimin CHEN Zhonglin | 2013 | EnvironmentalScience and Pollution Research2013，20，4： | 1 |
| 13 | 19-23 alkyliminodimethylenephosphonic acid, a new extractant for gold from acidic thiourea solutions显示文摘 | Yu songling Yu jimin Yu Zhonquan | 1993 | Hydrometallurgy1993，32，： | 1 |
| 14 | Generalized Mittag-leffier stability of muti-variables fractional-order nonlinear systems显示文摘 | Yu Jimin Hu Hua Zhou Shangbo Lin Xiaoran | 2013 | Automatica2013，49，： | 1 |
| 15 | 19 -23 Alkyliminodimethylene- phosphonic acid, a new extractant for gold from acidic thiourea solutions显示文摘 | Yu Songling Yu Jimin Yu Zhonquan | 1993 | Hydrometallurgy1993，32，： | 1 |
| 16 | Adaptive Control Design for High-order MIMO Nonlinear Time-delay Systems Based on Neural Network显示文摘 | Jimin Yu Zhixu Peng Linqin Cai Baohua Wu | 2014 | 控制工程期刊(中英文版)2014，4，2： | 0 |
| 17 | Diboron-mediated palladium-catalyzed asymmetric transfer hydrogenation using the proton of alcohols as hydrogen source显示文摘The developments of hydrogen sources stand at the forefront of asymmetric reduction. In contrast to the well-studied alcohols as hydrogen sources via β-hydride elimination, the direct utilization of the proton of alcohols as a hydrogen source for activatormediated asymmetric reduction is rarely explored. Herein we report the proton of alcohols as a hydrogen source in diboronmediated palladium-catalyzed asymmetric transfer hydrogenation of 1,3-diketones and indoles, providing a series of chiral β-hydroxy ketones and indolines with excellent yields and enantioselectivities. This strategy would be useful for the synthesis of chiral deuterium-labelled compounds due to the ready availability of deuterium-labelled alcohols. Mechanistic investigations and DFT calculations revealed that active chiral Pd-H species was generated from the proton of alcohols by activating of tetrahydroxydiboron, hydrogen transfer was the rate-determining step, and the reaction preferred Pd(0)-catalyzed mechanism. | Bo Wu Jimin Yang Shu-Bo Hu Chang-Bin Yu Zi-Biao Zhao Yi Luo Yong-Gui Zhou | 2021 | Science China Chemistry2021，64，10： | 0 |
| 18 | Repurposed benzydamine targeting CDK2 suppresses the growth of esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma (ESCC) is one of the leading causes of cancer death worldwide. It is urgent to develop new drugs to improve the prognosis of ESCC patients. Here, we found benzydamine, a locally acting non-steroidal anti-inflammatory drug, had potent cytotoxic effect on ESCC cells. Benzydamine could suppress ESCC proliferation in vivo and in vitro. In terms of mechanism, CDK2 was identified as a target of benzydamine by molecular docking, pull-down assay and in vitro kinase assay. Specifically, benzydamine inhibited the growth of ESCC cells by inhibiting CDK2 activity and affecting downstream phosphorylation of MCM2, c-Myc and Rb, resulting in cell cycle arrest. Our study illustrates that benzydamine inhibits the growth of ESCC cells by downregulating the CDK2 pathway. | Yubing Zhou Xinyu He Yanan Jiang Zitong Wang Yin Yu Wenjie Wu Chenyang Zhang Jincheng Li Yaping Guo Xinhuan Chen Zhicai Liu Jimin Zhao Kangdong Liu Zigang Dong | 2023 | Frontiers of Medicine2023，17，2： | 0 |
| 19 | Proteomics profiling of colorectal cancer progression identifies PLOD2 as a potential therapeutic target显示文摘Dear editors,Colorectal cancer(CRC)is the second leading cause of cancer deaths in developed countries[1].The malignant transformation from small clumps to cancer takes about 10 years[2].This study aimed to characterize proteomic dynamics associated with CRC development and progres-sion,and identify novel therapeutic targets for intercepting the underlying oncogenic processes.We have optimized pressure cycling technology(PCT)coupled with data-independent acquisition mass spectrometry(DIA-MS)for robust and reproducible proteomic analysis of biopsy-level formalin-fixed paraffin-embedded(FFPE)tissues[3]. | Yingkuan Shao Kailun Xu Xi Zheng Biting Zhou Xiuli Zhang Lin Wang Yaoting Sun Dan Li Ting Chen Jian Wang Shaojun Yu Lifeng Sun Xiaoming Xu Shaozhi Dai Huanhuan Gao Guan Ruan Wei Liu Xue Cai Tiansheng Zhu Lina Qi Jiani Chen Wangxiong Hu Xingyue Weng Yi Zhu Xueping Xiang Zhiyuan Hu Jinfan Li Lirong Chen Jimin Shao Shu Zheng Tiannan Guo | 2022 | Cancer Communications2022，42，2： | 0 |
| 20 | Performances of a prototype point-contact germanium detector immersed in liquid nitrogen for light dark matter search显示文摘The CDEX-10 experiment searches for light weakly interacting massive particles, a form of dark matter, at the China Jinping Underground Laboratory, where approximately 10 kg of germanium detectors are arranged in an array and immersed in liquid nitrogen. Herein, we report on the experimental apparatus, detector characterization, and spectrum analysis of one prototype detector. Owing to the higher rise-time resolution of the CDEX-10 prototype detector as compared with CDEX-1 B, we identified the origin of an observed category of extremely fast events. For data analysis of the CDEX-10 prototype detector, we introduced and applied an improved bulk/surface event discrimination method. The results of the new method were compared to those of the CDEX-1 B spectrum. Both sets of results showed good consistency in the 0-12 ke Vee energy range, except for the 8.0 keV K-shell X-ray peak from the external copper. | Hao Jiang LiTao Yang Qian Yue KeJun Kang JianPing Cheng YuanJing Li Henry Tsz-King Wong M.A?artio?lu HaiPeng An JianPing Chang JingHan Chen YunHua Chen Zhi Deng Qiang Du Hui Gong Li He Jin Wei Hu QingDong Hu HanXiong Huang LiPing Jia HauBin Li Hong Li Jian Min Li Jin Li Xia Li XueQian Li YuLan Li Bin Liao FongKay Lin ShinTed Lin ShuKui Liu YanDong Liu YuanYuan Liu ZhongZhi Liu Hao Ma JingLu Ma Hui Pan Jie Ren XiChao Ruan B.Sevda Vivek Sharma ManBin Shen Lakhwinder Singh Monoj Kumar Singh TianXi Sun ChangJian Tang WeiYou Tang Yang Tian GuangFu Wang JiMin Wang Li Wang Qing Wang Yi Wang ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue SongWei Yang Nan Yi ChunXu Yu HaiJun Yu JianFeng Yue XiongHui Zeng Ming Zeng Zhi Zeng FengShou Zhang YunHua Zhang MingGang Zhao JiFang Zhou ZuYing Zhou JingJun Zhu ZhongHua Zhu | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，3： | 0 |
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