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| 1 | One-step generation of p53 gene biallelic mutant Cynomolgus monkey via the CRISPR/Cas system显示文摘 | Haifeng Wan Chunjing Feng Fei Teng Shihua Yang Baoyang Hu Yuyu Niu Andy Peng Xiang Weizhen Fang Weizhi Ji Wei Li Xiaoyang Zhao Qi Zhou | 2015 | Cell Research2015，25，2： | 39 |
| 2 | SHP2 inhibition triggers anti-tumor immunity and synergizes with PD-1 blockade显示文摘Tyrosine phosphatase SHP2 is a promising drug target in cancer immunotherapy due to its bidirectional role in both tumor growth promotion and T-cell inactivation. Its allosteric inhibitor SHP099 is known to inhibit cancer cell growth both in vitro and in vivo. However, whether SHP099-mediated SHP2 inhibition retards tumor growth in vivo via anti-tumor immunity remains elusive. To address this, a CT-26 colon cancer xenograft model was established in mice since this cell line is insensitive to SHP099.Consequently, SHP099 minimally affected CT-26 tumor growth in immuno-deficient nude mice, but significantly decreased the tumor burden in CT-26 tumor-bearing mice with intact immune system.SHP099 augmented anti-tumor immunity, as shown by the elevated proportion of CD8tIFN-γtT cells and the upregulation of cytotoxic T-cell related genes including Granzyme B andPerforin, which decreased the tumor load. In addition, tumor growth in mice with SHP2-deficient T-cells was markedly slowed down because of enhanced anti-tumor responses. Finally, the combination of SHP099 and antiPD-1 antibody showed a higher therapeutic efficacy than either monotherapy in controlling tumor growthin two colon cancer xenograft models, indicating that these agents complement each other. Our study suggests that SHP2 inhibitor SHP099 is a promising candidate drug for cancer immunotherapy. | Mingxia Zhao Wenjie Guo Yuanyuan Wu Chenxi Yang Liang Zhong Guoliang Deng Yuyu Zhu Wen Liu Yanhong Gu Yin Lu Lingdong Kong Xiangbao Meng Qiang Xu Yang Sun | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 18 |
| 3 | Germline acquisition of Cas9/RNA-mediated gene modifications in monkeys显示文摘 | Yongchang Chen Yiqiang Cui Bin Shen Yuyu Niu Xiaoyang Zhao Lei Wang Jianying Wang Wei Li Qi Zhou Weizhi Ji Jiahao Sha Xingxu Huang | 2015 | Cell Research2015，25，2： | 8 |
| 4 | Doping bioactive elements into a collagen scaffold based on synchronous self-assembly/mineralization for bone tissue engineering显示文摘Pure collagen is biocompatible but lacks inherent osteoinductive,osteoimmunomodulatory and antibacterial activities.To obtain collagen with these characteristics,we developed a novel methodology of doping bioactive elements into collagen through the synchronous self-assembly/mineralization(SSM)of collagen.In the SSM model,amorphous mineral nanoparticles(AMN)(amorphous SrCO3,amorphous Ag3PO4,etc.)stabilized by the polyampholyte,carboxymethyl chitosan(CMC),and collagen molecules were the primary components under acidic conditions.As the pH gradually increased,intrafibrillar mineralization occurred via the self-adaptive interaction between the AMNs and the collagen microfibrils,which were self-assembling;the AMNs wrapped around the microfibrils became situated in the gap zones of collagen and finally transformed into crystals.Srdoped collagen scaffolds(Sr-CS)promoted in vitro cell proliferation and osteogenic differentiation of rat bone marrow mesenchymal stromal cells(rBMSCs)and synergistically improved osteogenesis of rBMSCs by altering the macrophage response.Ag-doped collagen scaffolds(Ag-CS)exhibited in vitro antibacterial effects on S.aureus,as well as cell/tissue compatibility.Moreover,Sr-CS implanted into the calvarial defect of a rat resulted in improved bone regeneration.Therefore,the SSM model is a de novo synthetic strategy for doping bioactive elements into collagen,and can be used to fabricate multifunctional collagen scaffolds to meet the clinical challenges of encouraging osteogenesis,boosting the immune response and fighting severe infection in bone defects. | Huanhuan Liu Mingli Lin Xue Liu Ye Zhang Yuyu Luo Yanyun Pang Haitao Chen Dongwang Zhu Xue Zhong Shiqing Ma Yanhong Zhao Qiang Yang Xu Zhang | 2020 | Bioactive Materials2020，5，4： | 6 |
| 5 | Incidence and clinical characteristics of inflammatory bowel disease in a developed region of G uangdong P rovince, C hina: A prospective population‐based study显示文摘 | Zhirong Zeng Zhenhua Zhu Yuyu Yang Weishan Ruan Xiabiao Peng Yuhuan Su Lin Peng Jinquan Chen Quan Yin Chao Zhao Haihua Zhou Shuai Yuan Yuantao Hao Jiaming Qian Siew Chien Ng Minhu Chen Pinjin Hu | 2013 | J Gastroenterol Hepatol2013，，7： | 5 |
| 6 | Principle and application of three-band gradient difference vegetation index显示文摘Vegetation index is a simple, effective and experiential measurement of terrestrial vegetation activity, and plays a very important role in qualitative and quantitative remote sensing. Aiming at shortages of current vegetation indices, and starting from the analysis of vegetation spectral characteristics, we put forward a new vegetation index, the three-band gradient difference vegetation index (TGDVI), and established algorithms to inverse crown cover fraction and leaf area index (LAI) from it. Theoretical analysis and model simulation show that TGDVI has high saturation point and the ability to remove the influence of background to some degree, and the explicit functional relation with crown cover fraction and LAI can be established. Moreover, study shows that TGDVI also has the ability to partly remove the influence of thin cloud. Experiment in the Shunyi District, Beijing, China shows that reasonable result can be reached using the vegetation index to retrieve LAI. We also theoretically analyzed the reason why the normalized difference vegetation index (NDVI) owns the low saturation point, and show that it is determined by the definition of NDVI and the characteristic of vegetation spectra, and is unavoidable to some degree. Meanwhile, through model simulation, we also indicate that the relationship between simple ratio vegetation index (SR) and LAI closes to a piecewise linear one instead of a linear one, which is mainly caused by the influence of background and different change rates of reflectance in red and infrared bands with LAI increasing. | TANG Shihao, ZHU Qijiang, WANG Jindi, ZHOU Yuyu & ZHAO Feng Research Center for Remote Sensing and GIS, Department of Geography, Beijing Normal University, Beijing 100875, China National Satellite Meteorological Center, China Meteorological Administration, Beijing 100081, China | 2005 | Science China Earth Sciences2005，48，2： | 4 |
| 7 | Versatile zero- to three-dimensional carbon for electrochemical energy storage显示文摘Secondary batteries have been widely developed and used in various fields,such as large-scale energy storage,portable electronics,and electric vehicles.Carbon-based materials have attracted considerable attention due to their abundance,environmental friendliness,tunable structure,and excellent chemical stability.Beyond the commercial carbon for batteries and supercapacitors,many studies focused on advanced and multifunctional carbon with various structures for electrochemical energy storage.This review summarizes the zero-to three-dimensional carbon-based materials and reviews their various electrochemical applications based on their structural characteristics.The importance of carbon structures and the relationship between materials'structures and electrochemical performance are discussed.Then,the prospects and potential challenges of using advanced carbon to formulate designs and develop novel carbonaceous materials with high electrochemical performance are further discussed. | Yuyue Zhao Yunlu Zhang Ying Wang Daxian Cao Xiao Sun Hongli Zhu | 2021 | Carbon Energy2021，3，6： | 3 |
| 8 | Highly stable and antifouling graphene oxide membranes prepared by bio-inspired modification for water purification显示文摘Graphene oxide(GO)membranes show great potential in molecular separation for water treatment.However,the inferior stability of GO membranes is a major bottleneck for practical applications.In this study,bio-inspired polydopamine(PDA)deposition is reported for enhancing the stability of GO membranes.Through simple and mild immersion,PDA is self-polymerized on GO membranes.The blocking of PDA chains to membrane defects improves the rejections for various molecules.Because the inherently strong adhesion and crosslinking of PDA greatly strengthen the interactions of substrates to GO layers and the binding force of GO nanosheets,the prepared PDA-GO membranes exhibit impressive long-te rm stability in cross-flow filtration,and maintain good nanofiltration perfo rmance at various feed pressures,tangential velocities,and eve n after external scratching.Moreover,because the deposited PDA layers obstruct the direct contact between GO and contaminants,the antifouling property of the PDA-GO membranes increases substantially,with recovery ratio about 98%. | Weiming Zhong Yuyu Zhang Ling Zhao Wanbin Li | 2020 | Chinese Chemical Letters2020，31，10： | 3 |
| 9 | Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos显示文摘 | Yuyu Niu Bin Shen Yiqiang Cui Yongchang Chen Jianying Wang Lei Wang Yu Kang Xiaoyang Zhao Wei Si Wei Li Andy Peng Xiang Jiankui Zhou Xuejiang Guo Ye Bi Chenyang Si Bian Hu Guoying Dong Hong Wang Zuomin Zhou Tianqing Li Tao Tan Xiuqiong Pu Fang Wang Shaohu | 2014 | Cell2014，，： | 3 |
| 10 | Warm dense matter research at HIAF显示文摘The research activities on warm dense matter driven by intense heavy ion beams at the new project High Intensity heavy-ion AcceleratorFacility (HIAF) are presented. The ion beam parameters and the simulated accessible state of matter at HIAF are introduced, respectively. Theprogresses of the developed diagnostics for warm dense matter research including high energy electron radiography, multiple-channel pyrometer,in-situ energy loss and charge state of ion detector are briefly introduced. | Rui Cheng Yu Lei Xianming Zhou Yuyu Wang Yanhong Chen Yongtao Zhao Jieru Ren Lina Sheng Jiancheng Yang Zimin Zhang Yingchao Du Wei Gai Xinwen Ma Guoqing Xiao | 2018 | Matter and Radiation at Extremes2018，3，2： | 2 |
| 11 | A study of highly charged ions transmission through polycarbonate nanocapillaries with multi-holes显示文摘 | Wang Xing Zhao Yongtao Wang Yuyu | | 0，，： | 1 |
| 12 | Potential and Kinetic Electron Emissions from HOPG Surface Irradiated by Highly Charged Xenon and Neon I0ns显示文摘 | Wang Yuyu Zhao Yongtao Sun Jianrong | | 0，，05： | 1 |
| 13 | A comparison of the mechanical properties of fibers spun from different carbon nanotubes显示文摘 | Jingjing Jia Jingna Zhao Geng Xu Jiangtao Di Zhenzhong Yong Yuyu Tao Chao Fang Zuoguang Zhang Xiaohua Zhang Lianxi Zheng Qingwen Li | 2010 | Carbon2010，，4： | 1 |
| 14 | Quantifying the response of surface urban heat island to urbanization using the annual temperature cycle model显示文摘Urban heat island(UHI),driving by urbanization,plays an important role in urban sustainability under climate change.However,the quantification of UHI’s response to urbanization is still challenging due to the lack of robust and continuous temperature and urbanization datasets and reliable quantification methods.This study proposed a framework to quantify the response of surface UHI(SUHI)to urban expansion using the annual temperate cycle model.We built a continuous annual SUHI series at the buffer level from 2003 to 2018 in the Jing-Jin-Ji region of China using MODIS land surface temperature and imperviousness derived from Landsat.We then investigated the spatiotemporal dynamic of SUHI under urban expansion and examined the underlying mechanism.Spatially,the largest SUHI interannual variations occurred in suburban areas compared to the urban center and rural areas.Temporally,the increase in SUHI under urban expansion was more significant in daytime compare to nighttime.We found that the seasonal variation of SUHI was largely affected by the seasonal variations of vegetation in rural areas and the interannual variation was mainly attributed to urban expansion in urban areas.Additionally,urban greening led to the decrease in summer daytime SHUI in central urban areas.These findings deepen the understanding of the long-term spatiotemporal dynamic of UHI and the quantitative relationship between UHI and urban expansion,providing a scientific basis for prediction and mitigation of UHI. | Huidong Li Yuyu Zhou Gensuo Jia Kaiguang Zhao Jinwei Dong | 2022 | Geoscience Frontiers2022，13，1： | 1 |
| 15 | Autopilot designmethod for the blended missile based on model predictivecontrol显示文摘 | YANG BAOQING ZHAO YUYU | 2015 | International Journal of Aerospace Engineering2015，2015，： | 1 |
| 16 | The point-of-care-testing of nucleic acids by chip, cartridge and paper sensors显示文摘Point-of-care nucleic acid testing(POCNAT) has played an important role in the outbreak of infectious diseases(e.g., COVID-19) over recent years. POCNAT aims to realize the rapid, simple and automatic detection of nucleic acid. Thanks to the development of manufacturing technology, electronic information technology, artificial intelligence technology, and biological information technology in recent years, the development of the POCNAT device has led to significant advancement. Instead of the normal nucleic acid detection methods used in the laboratory, some novel experimental carriers have been applied, such as chips, cartridges and papers. The application of these experimental carriers has realized the automation and integration of nucleic acid detection. The entire process of nucleic acid detection is normally divided into three steps(nucleic acid extraction, target amplification and signal detection). All of the reagents required by the process can be pre-stored on these experimental carriers, without unnecessary manual operation. Furthermore, all of the processes are carried out in this experimental carrier, with the assistance of a specific control device. Although they are complicated to manufacture and precise in design,their application provides a significant step forwards in nucleic acid detection and realizes the integration of nucleic acid detection. This technology has great potential in the field of point-of-care molecular diagnostics in the future. This paper focuses on the relevant content of these experimental carriers. | Yuyue Xu Tao Wang Zhu Chen Lian Jin Zuozhong Wu Jinqu Yan Xiaoni Zhao Lei Cai Yan Deng Yuan Guo Song Li Nongyue He | 2021 | Chinese Chemical Letters2021，32，12： | 1 |
| 17 | Concurrent highly pathogenic porcine reproductive and respiratory syndrome virus infection accelerates Haemophilus parasuis infection in conventional pigs显示文摘 | Jiang Yu Jiaqiang Wu Yuyu Zhang Lihui Guo Xiaoyan Cong Yijun Du Jun Li Wenbo Sun Jianli Shi Jun Peng Feifei Yin Dapeng Wang Pengwei Zhao Jinbao Wang | 2012 | Veterinary Microbiology (-)2012，，3： | 1 |
| 18 | The influence of the charged back side on the transmission of highly charged ions through PC nanocapillaries显示文摘 | Li Dehui Wang Yuyu Zhao Yongtao | 2009 | Nucl Instrum Meth B2009，267，： | 1 |
| 19 | Corrosion behavior,antibacterial ability,and osteogenic activity of Zn-incorporated Ni-Ti-O nanopore layers on NiTi alloy显示文摘Development of bone fixation devices with excellent corrosion resistance,antibacterial ability,and osteogenic activity is critical for promoting fracture healing.In this study,Zn-incorporated nanopore(NP)layers were prepared on the NiTi alloy through anodization and hydrothermal treatment.Results show that Zn can be evenly incorporated into the NP layers in the form of ZnTiO_(2).The Zn-incorporated samples exhibit good corrosion resistance and significantly reduce Ni^(2+)release.Meanwhile,the samples can continuously release Zn^(2+),which is responsible for excellent long-term antibacterial ability.Furthermore,the synergetic effect of Zn^(2+) release and nanoporous structure of the NP layers endues the NiTi alloy excellent osteogenic activity,as verified by upregulated alkaline phosphatase activity,secretion of type I collagen,and extracellular matrix mineralization.Therefore,Zn-incorporated Ni-Ti-O NP layers have great potential as biomedical coatings of NiTi-based implant materials. | Yonghua Sun Yuyu Zhao He Zhang Youjie Rong Runhua Yao Yi Zhang Xiaohong Yao Ruiqiang Hang | 2022 | Journal of Materials Science & Technology2022，，2： | 1 |
| 20 | Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos显示文摘 | Yuyu Niu Bin Shen Yiqiang Cui Yongchang Chen Jianying Wang Lei Wang Yu Kang Xiaoyang Zhao Wei Si Wei Li Andy Peng Xiang Jiankui Zhou Xuejiang Guo Ye Bi Chenyang Si Bian Hu Guoying Dong Hong Wang Zuomin Zhou Tianqing Li Tao Tan Xiuqiong Pu Fang Wang Shaohu | 2014 | Cell2014，，： | 1 |
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