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| 1 | Changes of plasma C-reactive protein in patients with craniocerebral injury before and after hyperbaric oxygenation: A randomly controlled study显示文摘BACKGROUND: Plasma inflammatory factor, such as C-reactive protein, whose content is regarded as a sensitively pathological marked protein and quantitative indexes of central nervous system injury, has been paid more and more attention in clinic. OBJECTIVE: To observe the effects and clinical significance of C-reactive protein in patients with craniocerebral injury after hyperbaric oxygenation. DESIGN: Randomized controlled study. SETTING: Departments of Neurosurgery, Laboratory and Hyperbaric Oxygen, the Second Affiliated Hospital, Medical College of Shantou University. PARTICIPANTS: A total of 60 patients with craniocerebral injury were selected from Department of Neurosurgery, the Second Affiliated Hospital, Medical College of Shantou University from October 2006 to April 2007. There were 37 males and 23 females and the mean age was 26 years. All subjects were certainly diagnosed as history of craniocerebral injury. Patients hospitalized at 24 hours after injury, Glasgow Coma Score ranged from 3 to 12 points, and all patients were certainly diagnosed with CT or MR scanning. Patients and their relatives provided confirmed consent. All the subjects were randomly divided into hyperbaric oxygenation group and control group with 30 in each group. METHODS: Patients in the control group were treated with routinely neurosurgical therapy after hospitalization; however, based the same basic treatment in the control group, patients in the hyperbaric oxygenation group received hyperbaric oxygenation by using iced-wheel four-door 2-cabin air-compression chamber (made in Yantai) from 24 hours to 10 days after operation or injury. After entering the cabin, patients who had a clear consciousness breathed the oxygen by using face mask; contrarily, patients directly breathed the oxygen. Therapeutic project: Expression was increased for about 15–20 minutes, maintained for about 70–80 minutes, and decreased for 20 minutes. Otherwise, pressure was maintained from 0.2 to 0.25 MPa. Hyperbaric oxygenation took an hour for once a day and 10 times were regarded as a course. Venous blood was collected before treatment and on the next day of the first course end. Content of C-reactive protein in plasma was measured with immune turbidimetry in hyperbaric oxygenation group; in addition, content of C-reactive protein in plasma was directly measured with the same method at the corresponding time in the control group. If the content was less or equal to 8 mg/L, it was regarded as normal value. Effects of the two groups were evaluated based on Glasgow Coma Score before and after treatment. MAIN OUTCOME MEASURES: Content of plasma C-reactive protein and Glasgow Coma Score in the two groups before and after treatment. RESULTS: All 60 patients were involved in the final analysis. ① Content of plasma C-reactive protein: The two contents were obviously higher than normal value after craniocerebral injury. There was no significant difference in the two groups before treatment (P > 0.05), but both contents were decreased after treatment, and there was significant difference between HBOT group and control group after treatment (t =4.756, P < 0.01). In addition, there was significant difference in hyperbaric oxygen therapy group before and after treatment (t =5.236, P < 0.01). ② Glasgow Coma Score: There was no significant difference in the two groups before treatment (P > 0.05), but scores were increased in both groups after treatment (t =9.92, 2.51, P < 0.01, 0.05); on the other hand, therefore, there was significant difference between the two groupsafter treatment (t =9.21, P < 0.01). CONCLUSION: Hyperbaric oxygenation can remarkably decrease content of plasma C-reactive protein in patients with craniocerebral injury at the phase of stress. | Zeyu Xie Minghua Zhuang Lan Lin Hongwu Xu Linxing Chen Lina Hu | 2007 | Neural Regeneration Research2007，2，5： | 9 |
| 2 | Advances in the Studies of the Middle and Upper Atmosphere in 2004 - 2006显示文摘This paper summarizes the research results obtained by Chinese scientists and/or through international collaborations during 2004 to 2006. Within the context of COSPAR, the progresses in the studies of the middle and upper atmosphere in China in the past two years are introduced with focusing the developments in facilities and instruments, and the advancements in scientific issues, e.g., dynamics related processes, atmospheric constituents, and the coupling with the lower atmosphere. | CHEN Zeyu LIU Renqiang CHEN Hongbin CHEN Wen LU Daren XU Jiyao HU Xiong | 2006 | 空间科学学报2006，26，z1： | 6 |
| 3 | Sensitive and selective molecularly imprinted electrochemical sensor based on multi-walled carbon nanotubes for doxycycline hyclate determination显示文摘An electrochemical sensor for doxycycline hyclate(DC)detection with high sensitivity and good selectivity is reported.The sensor was fabricated by electro-polymerization of molecularly imprinted polymers(MIPs)in the presence of DC onto multi-walled carbon nanotubes modified glassy carbon electrode(MWCNTs/GCE).The MWCNTs can significantly increase the current response of the sensor,leading to enhanced sensitivity.The MIPs provide selective recognition sites for DC detection.The experimental parameters,such as the polymer monomer concentration,supporting electrolyte pH,the time for electro-polymerization and the incubation time of the sensor with DC were optimized.Under optimized experimental conditions,the sensor displayed a linear range of 0.05μmol/L-0.5μmol/L towards DC detection,with the detection limit of 1.3×10^-2μmol/L.The sensor was successfully applied for recovery test of DC in human serum samples. | Zeyu Xu Xingxing Jiang Shuping Liu Minghui Yang | 2020 | Chinese Chemical Letters2020，31，1： | 6 |
| 4 | Systematically labeling developmental stage-specific genes for the study of pancreatic β-cell differentiation from human embryonic stem cells显示文摘 | Haisong Liu Huan Yang Dicong Zhu Xin Sui Juan Li Zhen Liang Lei Xu Zeyu Chen Anzhi Yao Long Zhang Xi Zhang Xing Yi Meng Liu Shiqing Xu Wenjian Zhang Hua Lin Lan Xie Jinning LOU Yong Zhang Jianzhong Xi Hongkui Deng | 2014 | Cell Research2014，24，10： | 3 |
| 5 | The adaptive transition of glioblastoma stem cells and its implications on treatments显示文摘Glioblastoma is the most malignant tumor occurring in the human central nervous system with overall median survival time<14.6 months.Current treatments such as chemotherapy and radiotherapy cannot reach an optimal remission since tumor resistance to therapy remains a challenge.Glioblastoma stem cells are considered to be responsible for tumor resistance in treating glioblastoma.Previous studies reported two subtypes,proneural and mesenchymal,of glioblastoma stem cells manifesting different sensitivity to radiotherapy or chemotherapy.Mesenchymal glioblastoma stem cells,as well as tumor cells generate from which,showed resistance to radiochemotherapies.Besides,two metabolic patterns,glutamine or glucose dependent,of mesenchymal glioblastoma stem cells also manifested different sensitivity to radiochemotherapies.Glutamine dependent mesenchymal glioblastoma stem cells are more sensitive to radiotherapy than glucose-dependent ones.Therefore,the transition between proneural and mesenchymal subtypes,or between glutamine-dependent and glucose-dependent,might lead to tumor resistance to radiochemotherapies.Moreover,neural stem cells were also hypothesized to participate in glioblastoma stem cells mediated tumor resistance to radiochemotherapies.In this review,we summarized the basic characteristics,adaptive transition and implications of glioblastoma stem cells in glioblastoma therapy. | Zeyu Wang Hao Zhang Shengchao Xu Zhixiong Liu Quan Cheng | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 3 |
| 6 | Challenges and innovations in treating chronic and acute wound infections:from basic science to clinical practice显示文摘Acute and chronic wound infection has become a major worldwide healthcare burden leading to significantly high morbidity and mortality.The underlying mechanism of infections has been widely investigated by scientist,while standard wound management is routinely been used in general practice.However,strategies for the diagnosis and treatment of wound infections remain a great challenge due to the occurrence of biofilm colonization,delayed healing and drug resistance.In the present review,we summarize the common microorganisms found in acute and chronic wound infections and discuss the challenges from the aspects of clinical diagnosis,non-surgical methods and surgical methods.Moreover,we highlight emerging innovations in the development of antimicrobial peptides,phages,controlled drug delivery,wound dressing materials and herbal medicine,and find that sensitive diagnostics,combined treatment and skin microbiome regulation could be future directions in the treatment of wound infection. | Xiaotong Ding Qinghan Tang Zeyu Xu Ye Xu Hao Zhang Dongfeng Zheng Shuqin Wang Qian Tan Joanneke Maitz Peter K.Maitz Shaoping Yin Yiwei Wang Jun Chen | 2022 | Burns & Trauma2022，10，1： | 3 |
| 7 | Control measures during the COVID-19 outbreak reduced the transmission of hand,foot,and mouth disease显示文摘Control measures during the coronavirus disease 2019(COVID-19)outbreak may have limited the spread of infectious diseases.This study aimed to analyze the impact of COVID-19 on the spread of hand,foot,and mouth disease(HFMD)in China.A mathematical model was established to fit the reported data of HFMD in six selected cities in China's Mainland from 2015 to 2020.The absolute difference(AD)and relative difference(RD)between the reported incidence in 2020,and simulated maximum,minimum,or median incidence of HFMD in 2015-2019 were calculated.The incidence and R effof HFMD have decreased in six selected cities since the outbreak of COVID-19,and in the second half of 2020,the incidence and R effof HFMD have rebounded.The results show that the total attack rate(TAR)in 2020 was lower than the maximum,minimum,and median TAR fitted in previous years in six selected cities(except Changsha City).For the maximum,median,minimum fitted TAR,the range of RD(%)is 42·20-99·20%,36·35-98·41%48·35-96·23%(except Changsha City)respectively.The preventive and control measures of COVID-19 have significantly contributed to the containment of HFMD transmission. | Yan Niu Li Luo Jia Rui Shiting Yang Bin Deng Zeyu Zhao Shengnan Lin Jingwen Xu Yuanzhao Zhu Yao Wang Meng Yang Xingchun Liu Tianlong Yang Weikang Liu Peihua Li Zhuoyang Li Chan Liu Jiefeng Huang Tianmu Chen | 2021 | Journal of Safety Science and Resilience2021，2，2： | 3 |
| 8 | Advances in Researches on the Middle and Upper Atmosphere in 2008-2010显示文摘This paper summarizes the results of the researches on the middle and upper atmosphere obtained by Chinese scientists in 2008-2010.The focuses are specifically placed on the researches being associated with ground-based observation capability development,dynamical processes,the property of atmospheric circulation and the chemistry-climate coupling of the middle atmospheric layers. | Chen Zeyu Chen Hongbin Lue Daren Xu Jiyao Chen Wen Tian Wenshou Ren Rongcai Hu Yongyun Huang Kaiming | 2010 | 空间科学学报2010，30，5： | 2 |
| 9 | Metamaterial Superstrate and Electromagnetic Band-Gap Substrate for High Directive Antenna显示文摘 | Huiliang Xu Zeyu Zhao Yueguang Lv Chunlei Du Xiangang Luo | 2008 | International Journal of Infrared and Millimeter Waves2008，，5： | 2 |
| 10 | Feasibility of Booster Vaccination in High-Risk Populations for Controlling Coronavirus Variants—China,2021显示文摘Introduction:Vaccination booster shots are completely necessary for controlling breakthrough infections of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in China.The study aims to estimate effectiveness of booster vaccines for high-risk populations(HRPs).Methods:A vaccinated Susceptible-Exposed-Symptomatic-Asymptomatic-Recovered/Removed(SEIAR)model was developed to simulate scenarios of effective reproduction number(Reff)from 4 to 6.Total number of infectious and asymptomatic cases were used to evaluated vaccination effectiveness.Results:Our model showed that we could not prevent outbreaks when covering 80%of HRPs with booster unless Reff=4.0 or the booster vaccine had efficacy against infectivity and susceptibility of more than 90%.The results were consistent when the outcome index was confirmed cases or asymptomatic cases.Conclusions:An ideal coronavirus disease 2019(COVID-19)booster vaccination strategy for HRPs would be expected to reach the initial goal to control the transmission of the Delta variant in China.Accordingly,the recommendation for the COVID-19 booster vaccine should be implemented in HRPs who are already vaccinated and could prevent transmission to other groups. | Kangguo Li Zeyu Zhao Hongjie Wei Jia Rui Jiefeng Huang Xiaohao Guo Yichao Guo Shiting Yang Guzainuer Abudurusuli Li Luo Xingchun Liu Yao Wang Jingwen Xu Yuanzhao Zhu Meng Yang TianlongYang Weikang Liu Bin Deng Chan Liu Zhuoyang Li Peihua Li Shanshan Yu Zimei Yang Yanhua Su Benhua Zhao Yan Niu Tianmu Chen | 2021 | China CDC weekly2021，3，50： | 2 |
| 11 | Linkage between teacher quality, student achievement,and cognitive skills: A rule-space model显示文摘 | Tao Xin Zeyu Xu Kikumi Tatsuoka | 2004 | Studies in Educational Evaluation2004，，3： | 1 |
| 12 | Molecular mechanisms of adaptive evolution in wild animals and plants显示文摘Wild animals and plants have developed a variety of adaptive traits driven by adaptive evolution,an important strategy for species survival and persistence.Uncovering the molecular mechanisms of adaptive evolution is the key to understanding species diversification,phenotypic convergence,and inter-species interaction.As the genome sequences of more and more non-model organisms are becoming available,the focus of studies on molecular mechanisms of adaptive evolution has shifted from the candidate gene method to genetic mapping based on genome-wide scanning.In this study,we reviewed the latest research advances in wild animals and plants,focusing on adaptive traits,convergent evolution,and coevolution.Firstly,we focused on the adaptive evolution of morphological,behavioral,and physiological traits.Secondly,we reviewed the phenotypic convergences of life history traits and responding to environmental pressures,and the underlying molecular convergence mechanisms.Thirdly,we summarized the advances of coevolution,including the four main types:mutualism,parasitism,predation and competition.Overall,these latest advances greatly increase our understanding of the underlying molecular mechanisms for diverse adaptive traits and species interaction,demonstrating that the development of evolutionary biology has been greatly accelerated by multi-omics technologies.Finally,we highlighted the emerging trends and future prospects around the above three aspects of adaptive evolution. | Yibo Hu Xiaoping Wang Yongchao Xu Hui Yang Zeyu Tong Ran Tian Shaohua Xu Li Yu Yalong Guo Peng Shi Shuangquan Huang Guang Yang Suhua Shi Fuwen Wei | 2023 | Science China(Life Sciences)2023，66，3： | 1 |
| 13 | Immunogenicity and protective immunity against otitis media caused by pneumococcus in mice of Hib conjugate vaccine with PsaA protein carrier显示文摘 | Zeyu Chen Rong Guo Jianghong Xu Chuangjun Qiu | 2016 | Frontiers of Medicine2016，10，4： | 1 |
| 14 | Preparation and character- ization of expanded perlite/paraffin composite as form-stable phase change material显示文摘 | Lu Zeyu Xu Biwan Zhang Jinrui | 2014 | Solar Energy2014，108，： | 1 |
| 15 | Vaccination with the repeat β-hCG C-terminal peptide carried by heat shock protein-65 (HSP65) for inducing antitumor effects显示文摘 | Jie Yang Yankai Zhang Huaqian Wang Zhenqiu Gao Zeyu Wang Bin Liu Xiuhua Zhang Mingzhu Du Xiao Huang Maolei Xu Jie Wu Taiming Li Jingjing Liu Rongyue Cao | 2012 | Tumor Biology2012，，： | 1 |
| 16 | Methane production in simulated hybrid bioreactor landfill显示文摘 | Qiyong Xu Xiao Jin Zeyu Ma Huchun Tao Jae Hac Ko | 2014 | Bioresource Technology2014，，： | 1 |
| 17 | Effect and mechanism of CyPA in radiosensitization of lung adenocarcinoma using CRISPR/Cas9 technology显示文摘Objective:To explore the role of cyclophilin A(CyPA)in sensitization of lung adenocarcinoma to radiotherapy using CRISPR/Cas9 technology.Methods:A CyPA knockout human lung adenocarcinoma cell line H1975 was established by CRISPR/Cas9 technology.Groups included a control group(wildtype),CyPA knockout group,traditional Chinese medicine(TCM)extract with Fuzhengzengxiao decoction group,and TCM extract with Fuzhengzengxiao decoction t CyPA knockout group.Each group was exposed to radiation at doses of 0,2,4,6,and 8 Gy.After 24 h,MTT assays were used to determine the survival rate of lung cancer cells and calculate radiosensitivity.The qPCR was used to measure mRNA expression of DDIT3,CDKN1A,and CDC25A associated with DNA damage repair.Results:Without irradiation,Fuzhengzengxiao decoction reduced the survival rate of lung adenocarcinoma cells(P<.0001).After irradiation,TCM extract with Fuzhengzengxiao decoction,CyPA knockout,and TCM extract with Fuzhengzengxiao decoction t CyPA knockout groups had reduced survival rates(P<.0001)and radiosensitivity was increased significantly.Expression of DDIT3,CDKN1A,and CDC25A was upregulated after knockout of CyPA(P<.0001).Expression of DDIT3 and CDC25A was increased after irradiation in wildtype cells treated with TCM extract with Fuzhengzengxiao decoction(DDIT3,P<.0001;CDC25A,P紏.0059).The TCM extract with Fuzhengzengxiao decoction t CyPA knockout group also had increased expression of DDIT3 and CDC25A after irradiation(P<.0001).Conclusion:Fuzhengzengxiao decoction significantly decreases the survival rate of lung cancer cells,and its mechanism may be related to radiosensitization by decreasing expression of CyPA and inducing G1/S cell cycle arrest. | Jinkun Ma Lin Xu Jinchang Huang Qiaoli Zhang Yuqin Qiu Xuewei Qi Lina Wang Yuchan Cao Zeyu Liu Shiyun Liu | 2020 | Journal of Traditional Chinese Medical Sciences2020，7，1： | 1 |
| 18 | Metamaterial Superstrate and Electromagnetic Band-Gap Substrate for High Directive Antenna显示文摘 | Huiliang Xu Zeyu Zhao Yueguang Lv Chunlei Du Xiangang Luo | 2008 | International Journal of Infrared and Millimeter Waves2008，，5： | 1 |
| 19 | Role of the neuroendocrine antimicrobial peptide catestatin in innate immunity and pain显示文摘Catestatin (CST ) 是从 chromogranin A 被导出的 neuroendocrine 肽。CST 能影响大量过程,这被表明了,例如天生的免疫,煽动性、自体免疫的反应,和几条 homeostatic 规定。而且, CST 对在 micromolecular 范围的几种细菌的紧张是确定的,它显示出它的抗菌剂活动。最近,剧烈、长期的疼痛地的 CST 的角色吸引了许多注意。在这评论,我们在天生的免疫和疼痛讨论了 CST 和它的角色的最近的研究调查结果(吗?作者 2017。代表生物化学和房间生物学的研究所由牛津大学出版社出版了,为生物科学的上海研究所,中国科学院。版权所有。为权限,请发邮件:journals.permissions@oup.com。) | Zeyu Deng Changshui Xu | 2017 | Acta Biochimica et Biophysica Sinica2017，49，11： | 1 |
| 20 | Evaluation of coal bed methane content using BET adsorption isotherm equation显示文摘Coal bed methane is unconventional raw natural gas stored in coal seam with considerable reserves in China.In recent years,as the coal bed methane production,the safety and the use of resources have been paid more attentions.Evaluating coal bed methane content is an urgent problem.A BET adsorption isotherm equation is used to process the experimental data.The various parameters of BET equation under different temperatures are obtained;a theoretical gas content correction factor is proposed,and an evaluation method of actual coal bed methane is established. | ZHANG Yi FAN Xiaomin HAN Xue NAN Zeyu XU Jun | 2012 | Global Geology2012，15，1： | 1 |
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