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| 1 | Alendronate loaded graphene oxide functionalized collagen sponge for the dual effects of osteogenesis and anti-osteoclastogenesis in osteoporotic rats显示文摘Graphene Oxide(GO)-related hydrogels have been extensively studied in hard tissue repair,because GO can not only enhance the mechanical properties of polymers but also promote osteogenic differentiation of mesenchymal stem cells.However,simple GO-related hydrogels are not ideal for the repair of osteoporotic bone defects as the overactive osteoclasts in osteoporosis.Alendronate(Aln)is known to inhibit osteoclasts and may bind to GO through covalent connection.Therefore,delivering Aln in GO-related hydrogels may be effective to repair osteoporotic bone defects.Here,we developed a control-released system which is constructed by collagen(Col)-GO sponges loaded with Aln(Col-GO-Aln)for osteoporotic bone defect repair.In vitro,Col-GO-Aln sponges prolonged the release period of Aln,and the sponge containing 0.05%(w/v)GO released Aln faster than sponge with 0.2%GO.Furthermore,tartrate-resistant acid phosphatase(TRAP)and F-actin staining demonstrated that Col-GO-Aln sponges effectively inhibited osteoclastogenesis of monocyte-macrophages.In vivo,micro-CT scan showed that the volume of newborn bone in defect site by 0.05%GO sponge was nearly three times larger than that of other groups.Moreover,the CT and histological examinations of rat femur proved that Col-GO-Aln sponges decreased the number of osteoclasts and suppressed the systemic bone loss in osteoporotic rats.These findings reveal that the application of GO as carriers of anti-osteoporosis drugs is a viable treatment for osteoporosis.The results also underscore the potential of GO-related hydrogels with Aln-releasing capacity for bone regeneration in osteoporosis. | Yuyang Zeng Muran Zhou Lifeng Chen Huimin Fang Shaokai Liu Chuchao Zhou Jiaming Sun Zhenxing Wang | 2020 | Bioactive Materials2020，5，4： | 10 |
| 2 | Designing N-doped graphene/ReSe_(2)/Ti_(3)C_(2) MXene heterostructure frameworks as promising anodes for high-rate potassium-ion batteries显示文摘Developing high-performance anodes for potassium ion batteries(KIBs) is of paramount significance but remains challenging.In the normal sense,electrode materials are prepared by ubiquitous wet chemical routes,which otherwise might not be versatile enough to create desired heterostructures and/or form clean interfacial areas for fast transport of K-ions and electrons.Along this line,rate capability/cycling stability of resulting KIBs are greatly handicapped.Herein we present an all-chemical vapor deposition approach to harness the direct synthesis of nitrogen-doped graphene(NG)/rhenium diselenide(ReSe_2)hybrids over three-dimensional MXene supports as superior heterostructure anode material for KIBs.In such an innovative design,1 T'-ReSe2 nanoparticles are sandwiched in between the NG coatings and MXene frameworks via strong interfacial interactions,thereby affording facile K~+ diffusion,enhancing overall conductivity,boosting high-power performance and reinforcing structural stability of electrodes.Thus-constructed anode delivers an excellent rate performance of 138 mAh g^(-1) at 10.0 A g^(-1) and a high reversible capacity of 90 mAh g^(-1) at 5 A g^(-1) after 300 cycles.Furthermore,the potassium storage mechanism has been systematically probed by advanced in situlex situ characterization techniques in combination with first principles computations. | Zhou Xia Xiwen Chen Haina Cia Zhaodi Fan Yuyang Yi Wanjian Yin Nan Wei Jingsheng Cai Yanfeng Zhang Jingyu Sun | 2021 | Journal of Energy Chemistry2021，30，2： | 9 |
| 3 | MicroRNA-638 inhibits cell proliferation by targeting phospholipase D1 in human gastric carcinoma显示文摘MicroRNAs (miRNAs ) 是经常是玩的小非编码的 RNA 的一种类型在 carcinogenesis 的重要角色,而是 miRNAs 的 carcinogenic 机制仍然是不清楚的。这研究将在癌(GC ) 调查功能和 miR-638 的机制。在 GC 和 miR-638 的 DNA 拷贝数字的 miR-638 的表示被即时 PCR 检测。房间增长上的 miR-638 的效果被数 kit-8 试金测量。不同试金,包括生物信息学算法(TargetScan 并且人权保护) ,酶报告试金并且西方的弄污,被用来在 GC 识别 miR-638 的目标基因。在临床的 CRC 纸巾的 miR-638 目标基因的表示被 immunohistochemical 试金也验证。从这研究,我们发现 miR-638 与相应 noncancerous 纸巾(NCT ) 相比是在 GC 纸巾的 downregulated,并且 miR-638 的 DNA 拷贝数字比 NCT 在 GC 是更低的,它可以在 GC 导致 miR-638 的相应 downregulation。miR-638 的宫外的表示在 vitro 禁止了 GC 细胞生长。随后,我们鉴别 PLD1 是在 GC,和 silencing PLD1 表示 phenocopied 的 miR-638 的目标基因 GC 房间增长上的 miR-638 的禁止的效果。而且,我们观察到 PLD1 是在在预言的 GC 的 PLD1 的 GC 纸巾,和高表示的 overexpressed 差的全面幸存。在摘要,我们表明 miR-638 通过禁止 PLD1 在 GC 作为肿瘤 suppressor 工作。 | Jiwei Zhang Zehua Bian Jialiang Zhou Mingxu Song Zhihui Liu Yuyang Feng Li Zhe Binbin Zhang Yuan Yin Zhaohui Huang | 2015 | Protein & Cell2015，6，9： | 8 |
| 4 | Precise synthesis of N-doped graphitic carbon via chemical vapor deposition to unravel the dopant functions on potassium storage toward practical K-ion batteries显示文摘Nitrogen doped carbon is a burgeoning anode candidate for potassium-ion battery(PIBs)owing to its outstanding attributes.It is imperative to grasp further insight into specific effects of different nitrogen dopants in carbon anode toward advanced K-ion storage.However,the prevailing fabrication method is plagued by the fact that considerable variations in the total N-doping concentration occur in the course of regulating the type of nitrogen dopants,incapable of distinguishing the certain roles of them under similar conditions.Herein,throughout the precise preparation of high edge-N doped carbon(HENC)and high graphitic-N doped carbon(HGNC)harnessing basically identical N-doping levels(5.78 at.%for HENC;5.07 at.%for HGNC)via chemical vapor deposition route,the effects of edge-N and graphitic-N in the carbon anode on K-ion storage are revisited,offering guidance into the design of low-cost and high-performance PIB systems. | Yu Zhao Zhongti Sun Yuyang Yi Chen Lu Menglei Wang Zhou Xia Xueyu Lian Zhongfan Liu Jingyu Sun | 2021 | Nano Research2021，14，5： | 4 |
| 5 | All VN-graphene architecture derived self-powered wearable sensors for ultrasensitive health monitoring显示文摘The booming of wearable electronics has nourished the progress on developing multifunctional energy storage systems with versatile flexibility, which enable the continuous and steady power supply even under various deformed states. In this sense, the synergy of flexible energy and electronic devices to construct integrative wearable microsystems is meaningful but remains quite challenging by far. Herein, we devise an innovative supercapacitor/sensor integrative wearable device that is based upon our designed vanadium nitride-graphene (VN-G) architectures. Flexible quasi-solid-state VN-G supercapacitor with ultralight and binder-free features deliver a specific capacitance of^53 F·g^-1 with good cycle stability. On the other hand, VN-G derived pressure sensors fabricated throughout a spray-printing process also manifest favorably high sensitivity (40 kPa^-1 at the range of 2-10 kPa), fast response time (~130 ms), perfect skin conformability, and outstanding stability under static and dynamic pressure conditions. In tum, their complementary unity into a self-powered wearable sensor enables the precise detecti on of physiological motions ranging from pulse rate to phonetic recognition, holding promise for in-practical health monitoring applications. | Lianghao Yu Yuyang Yi Ting Yao Yingze Song Yiran Chen Qiucheng Li Zhou Xia Nan Wei Zhengnan Tian Baoqing Nie Li Zhang Zhongfan Liu Jingyu Sun | 2019 | Nano Research2019，12，2： | 4 |
| 6 | Effect of sulfur source on photocatalytic degradation performance of CdS/MoS2 prepared with one-step hydrothermal synthesis显示文摘Cd S/Mo S_2,an extremely efficient photocatalyst,has been extensively used in hydrogen photoproduction and pollutant degradation.Cd S/Mo S_2can be synthesized by a facile one-step hydrothermal process.However,the effect of the sulfur source on the synthesis of Cd S/Mo S_2via one-step hydrothermal methods has seldom been investigated.We report herein a series of one-step hydrothermal preparations of Cd S/Mo S_2using three different sulfur sources:thioacetamide,L-cysteine,and thiourea.The results revealed that the sulfur source strongly affected the crystallization,morphology,elemental composition and ultraviolet(UV)–visible-light-absorption ability of the Cd S/Mo S_2.Among the investigated sulfur sources,thioacetamide provided the highest visible-light absorption ability for Cd S/Mo S_2,with the smallest average particle size and largest surface area,resulting in the highest efficiency in Methylene Blue(MB)degradation.The photocatalytic activity of Cd S/Mo S_2synthesized from the three sulfur sources can be arranged in the following order:thioacetamide>L-cysteine>thiourea.The reaction rate constants(k)for thioacetamide,L-cysteine,and thiourea were estimated to be 0.0197,0.0140,and 0.0084 min^(-1),respectively.However,thioacetamide may be limited in practical application in terms of its price and toxicity,while L-cysteine is relatively economical,less toxic and exhibited good photocatalytic degradation performance toward MB. | Yanfeng Wang Wei Chen Xiao Chen Huajun Feng Dongsheng Shen Bin Huang Yufeng Jia Yuyang Zhou Yuxiang Liang | 2018 | Journal of Environmental Sciences2018，30，3： | 3 |
| 7 | Gadolinium-hyaluronic acid nanoparticles as an efficient and safe magnetic resonance imaging contrast agent for articular cartilage injury detection显示文摘Accurate detection of cartilage injuries is critical for their proper treatment because these injuries lack the selfhealing ability and lead to joint dysfunction.However,the low longitudinal T1 relaxivity(r1)and non-specificity of contrast agents(such as gadolinium(III)-diethylenetriamine-pentaacetic acid(Gd-DTPA))significantly limit the efficiency of clinical magnetic resonance imaging(MRI)applications.To overcome these drawbacks,we integrated hyaluronic acid(HA)with Gd to synthesize a Gd-DTPA-HA composite,which was subsequently freeze-dried to produce nanoparticles(NPs).The resultant Gd-HA NPs demonstrated a greater r1 value(12.51 mM^-1 s^-1)compared with the bulk Gd-DTPA-HA(8.37 mM^-1 s^-1)and clinically used Gd-DTPA(3.88 mM^-1 s^-1).Moreover,the high affinity of HA to the cartilage allowed these NPs to penetrate deeper beyond the cartilage surface.As a result,Gd-HA NPs considerably increased the quality of cartilage and lesion MR images via their intra-articular injection in vivo.Specifically,2 h after NP administration,the signal-to-noise ratio at the injured cartilage site was 2.3 times greater than the value measured before the injection.In addition,Gd-HA NPs exhibited good biosafety properties due to the absence of adverse effects in the blood or on the main organs.It was also showed that Gd NPs were first metabolized by the kidney and liver and then excreted from the body with urine.Thus,Gd-HA NPs can potentially serve as an efficient MRI contrast agent for improved detection of cartilage injuries. | Rong Lu Yuyang Zhang Hongyue Tao Lu Zhou Huidi Li Tianwu Chen Peng Zhang Yao Lu Shuang Chen | 2020 | Bioactive Materials2020，5，4： | 3 |
| 8 | Response of coralline algae Porolithon onkodes to elevated seawater temperature and reduced pH显示文摘Coralline algae(CA),a type of primary calcifying producer presented in coastal ecosystems,are considered one of the highly sensitive organisms to marine environmental change.However,experimental studies on coralline algae responses to elevated seawater temperature and reduced pH have documented either contradictory or opposite results.In this study,we analysed the growth and physiological responses of coralline algae Porolithon onkodes to the elevated temperature(30.8°C)and reduced pH(7.8).The aim of this analysis was to observe the direct and combined effects,while elucidating the growth and photosynthesis in this response.It was demonstrated that the algae thallus growth rate and photosynthesis under elevated temperature were depressed by 21.5%and 14.9%respectively.High pCO2 enhanced the growth and photosynthesis of the thallus at ambient temperature,while they were deceased when both temperature and pCO2 were elevated.CA is among the most sensitive organisms to ocean acidification(OA)because of their precipitate high Mg-calcite.We hypothesize that coralline algae could increase their calcification rate in order to counteract the effects of moderate acidification,but offset by the effect of elevated temperature.Accordingly,our results also support the conclusion that global warming(GW)is a stronger threat to algal performance than OA.Our findings are also proposed that coralline algae may be more resilient under OA than GW. | Xinming Lei Lei Jiang Yuyang Zhang Guowei Zhou Jiansheng Lian Hui Huang | 2020 | Acta Oceanologica Sinica2020，39，2： | 2 |
| 9 | Vacancy manipulating of molybdenum carbide MXenes to enhance Faraday reaction for high performance lithium-ion batteries显示文摘“Intrinsic”strategies for manipulating the local electronic structure and coordination environment of defect-regulated materials can optimize electrochemical storage performance.Nevertheless,the structure–activity relationship between defects and charge storage is ambiguous,which may be revealed by constructing highly ordered vacancy structures.Herein,we demonstrate molybdenum carbide MXene nanosheets with customized in-plane chemical ordered vacancies(Mo_(1.33)CT_(x)),by utilizing selective etching strategies.Synchrotron-based X-ray characterizations reveal that Mo atoms in Mo1.33CTx show increased average valence of+4.44 compared with the control Mo_(2)CT_(x).Benefited from the introduced atomic active sites and high valence of Mo,Mo_(1.33)CT_(x)achieves an outstanding capacity of 603 mAh·g^(−1)at 0.2 A·g^(−1),superior to most original MXenes.Li+storage kinetics analysis and density functional theory(DFT)simulations show that this optimized performance ensues from the more charge compensation during charge–discharge process,which enhances Faraday reaction compared with pure Mo_(2)CT_(x).This vacancy manipulation provides an efficient way to realize MXene’s potential as promising electrodes. | Xin Guo Changda Wang Wenjie Wang Quan Zhou Wenjie Xu Pengjun Zhang Shiqiang Wei Yuyang Cao Kefu Zhu Zhanfeng Liu Xiya Yang Yixiu Wang Xiaojun Wu Li Song Shuangming Chen Xiaosong Liu | 2022 | Nano Research Energy2022，1，3： | 2 |
| 10 | Clinical observation on Wang Juyi's applied channel theory in treating stroke-sequel patients显示文摘OBJECTIVE:To explore the advantages of acupuncture treatment guided by channel palpation on stroke-sequel patients.METHODS:This research was randomized,traditional acupuncture controlled trial using channel palpation acupuncture to treat stroke-sequel patients.Totally 148 patients who were randomly assigned to two experimental groups.The treatment group,i.e,the channel palpation group was treated with Dr.Wang Juyi's Channel Palpation.Patients in control group received acupuncture according to New Century Acupuncture.Every patient was needled at Renzhong(GV 26),Baihui(GV 20),Neiguan(PC 6),Jiquan(HT 1),Chize(LU 5),Weizhong(BL 40),Sanyinjiao(SP 6),Zusanli(ST 36),and each acupuncture treatment was modified according different syndrome differentiations including liver yang rising [Taichong(LR 3),Taixi(KI 3)],wind-phlegm blocking collaterals [Fenglong(ST 40),Hegu(LI 4)],phlegm-heat occupying in the Fu-organs [Quchi(LI11),Neiting(ST 44),Fenglong(ST 40)],Qi deficiency with blood stasis [Qihai(CV 6),Xuehai(SP 10)],Yin Deficiency with wind [Taixi(KI 3),Fengchi(GB 20)];for wry mouth,add Jiache(ST 6),Dicang(ST 4);for paralyzed arms,add Jianyu(LI 15),Quchi(LI 11),Shousanli(LI 10) and Hegu(LI 4),for paralyzed legs,add Huantiao(GB 30),Yinlingquan(SP 9) and Fengshi(GB 31).The duration of each treatment was 6 weeks.Then the Fugl-Meyer score,the Stroke Specific Quality of Life scale(SS-QOL),and the National Institute of Health Stroke Scale(NIHSS) were assessed before treatments,after 6 and 12 weeks of treatments to evaluate the acupuncture effect in each group.The data were collected and analyzed after the completion of treatment by SPSS 17 using paired sample t-test.RESULTS:Totally 148 participants were recruited,and 136 eligible patients were included in this study.The results showed that for FMA motor function and Fugl-Meyer balance function and NIHSS,there is no statistic difference between two groups at the baseline period,after 6-week treatment and after 12-week follow-up(P > 0.05);However,for NIHSS and SS-QOL,there is no statistic difference between two groups at the baseline period and 6 weeks after treatment(P > 0.05).However,statistical difference starts to appear after 12-week(P =0.028,0.037 < 0.05).CONCLUSION:We conclude that as for improving the nerve function and the quality of life,Dr.Wang Juyi's Applied Channel Theory presents a better clinical result. | Luo Lu Yu Zheng Yang Yuyang Liu Jing Zhou Wei Wang Juyi | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 1 |
| 11 | How do Cats Resist Landing Injury:Insights into the Multi-level Buffering Mechanism显示文摘When humans jump down from a high position,there is a risk of serious injury to the lower limbs.However,cats can jump down from the same heights without any injury because of their excellent ability to attenuate impact forces.The present study aims to investigate the macro/micro biomechanical features of paw pads and limb bones of cats,and the coordination control of joints during landing,providing insights into how cats protect themselves from landing injury.Accordingly,histological analysis,radiological analysis,finite element method,and mechanical testing were performed to investigate the mechanical properties,microstructure,and biomechanical response of the pads and limb bones.In addition,using a motion capture system,the kinematic/kinetic data during landing were analysed based on inverse dynamics.The results show that the pads and limb bones are major contributors to non-impact-injuries,and cats actively couple their joints to adjust the parameters of movement to dissipate the higher impact.Therefore,the paw pads,limb bones,and coordinated joints complement each other and constitute a multi-level buffering mechanism,providing the cat with the sophisticated shock absorption system.This biomechanical analysis can accordingly provide biological inspiration for new approaches to prevent human lower limb injuries. | Xueqing Wu Baoqing Pei Yuyang Pei Wei Wang Yan Hao Kaiyuan Zhou | 2020 | Journal of Bionic Engineering2020，17，3： | 1 |
| 12 | Optimization on microstructure,mechanical properties and damping capacities of duplex structured Mg–8Li–4Zn–1Mn alloys显示文摘Optimizing the mechanical properties and damping capacity of the duplex-structured Mg–Li–Zn–Mn alloy by tailoring the microstructure via hot extrusion was investigated.The results show that the Mg–8Li–4Zn–1Mn alloy is mainly composed ofα-Mg,β-Li,Mg–Li–Zn and Mn phases.The microstructure of the test alloy is refined owing to dynamic recrystallization(DRX)during hot extrusion.After hot extrusion,the crushed precipitates are uniformly distributed in the test alloy.The yield strength(YS),ultimate tensile strength(UTS),and elongation(EL)of as-extruded alloy reach 156 MPa,208 MPa,and 32.3%,respectively,which are much better than that of as-cast alloy.Furthermore,the as-extruded and as-cast alloys both exhibit superior damping capacities,with the damping capacity(Q^(-1))of 0.030 and 0.033 at the strain amplitude of 2×10^(-3),respectively.The mechanical properties of the test alloy can be significantly improved by hot extrusion,whereas the damping capacities have no noticeable change,which indicates that the duplex-structured Mg–Li alloys with appropriate mechanical properties and damping properties can be obtained by alloying and hot extrusion. | Tongtong Cao Yong Zhu Yuyang Gao Yan Yang Gang Zhou Xiaofei Cui Chen Wen Bin Jiang Xiaodong Peng Fusheng Pan | 2023 | International Journal of Minerals,Metallurgy and Materials2023，30，5： | 1 |
| 13 | Upregulation of CENPM facilitates lung adenocarcinoma progression via PI3K/AKT/mTOR signaling pathway显示文摘Centromere protein M(CENPM)is essential for chromosome separation during mitosis.However,its roles in lung adenocarcinoma(LUAD)progression and metastasis remain unknown.In this study,we aimed to explore the effects of CENPM on LUAD progression as well as the underlying mechanisms.We analyzed the expression of CENPM and its correlation with clinicopathological characteristics using GEO LUAD chip datasets and TCGA dataset.We further investigated the impact of CENPM on LUAD in vitro and in vivo.In silico analysis and qRT-PCR revealed that CENPM is upregulated in LUAD compared with that in normal lung tissues.Via gain/loss-of-function assays,we further found that CENPM promotes the LUAD cell cycle,cell proliferation,migration and invasion,and inhibits cell apoptosis in vitro.The in vivo study showed that loss of CENPM inhibits the growth of A549 xenografts.Furthermore,we found that CENPM can promote the phosphorylation of mTOR rather than directly affect the mTOR content.Inhibition of mTOR activity abrogates the promoting effects of CENPM on cell cycle progression,cell proliferation,migration and invasion.Taken together,these results show that CENPM plays an important role in the growth and metastasis of LUAD and may be a promising therapeutic target in LUAD. | Chao Liu Yun Wang Yuyang Dao Shuting Wang Fei Hou Zhixian Yang Pengjie Liu Juan Lv Ling Lv Gaofeng Li Youjun Zhou Zhiyong Deng | 2022 | Acta Biochimica et Biophysica Sinica2022，54，1： | 1 |
| 14 | Sulfate reduction behavior in pressure-bearing leachate saturated zone显示文摘Attention should be paid to the sulfate reduction behavior in a pressure-bearing leachate saturated zone.In this study,within the relative pressure range of 0–0.6 MPa,the ambient temperature with the highest sulfate reduction rate of 50℃ was selected to explore the difference in sulfate reduction behavior in a pressure-bearing leachate saturated zone.The results showed that the sulfate reduction rate might further increase with an increase in pressure;however,owing to the effect of pressure increase,the generated hydrogen sulfide (H_(2)S) could not be released on time,thereby decreasing its highest concentration by approximately 85%,and the duration extended to about two times that of the atmospheric pressure.Microbial community structure and functional gene abundance analyses showed that the community distribution of sulfate-reducing bacteria was significantly affected by pressure conditions,and there was a negative correlation between disulfide reductase B(dsrB) gene abundance and H_(2)S release rate.Other sulfate reduction processes that do not require disulfide reductase A (dsrA) and dsrB genes may be the key pathways affecting the sulfate reduction rate in the pressure-bearing leachate saturated zone.This study improves the understanding of sulfate reduction in landfills as well as provides a theoretical basis for the operation and management of landfills. | Dongsheng Shen Haomin Zhou Zhiyuan Jin Wenyi Yang Manting Ci Yuyang Long Lifang Hu | 2023 | Journal of Environmental Sciences2023，，4： | 1 |
| 15 | Elevated Plasma IL-37, IL-18, and IL-18BP Concentrations in Patients with Acute Coronary Syndrome显示文摘 | Qingwei Ji Qiutang Zeng Ying Huang Ying Shi Yingzhong Lin Zhengde Lu Kai Meng Bangwei Wu Kunwu Yu Meng Chai Yuyang Liu Yujie Zhou Alex Kleinjan | 2014 | Mediators of Inflammation2014，，： | 1 |
| 16 | Literature analysis of Dendrolimus disasters based on remote sensing monitoring显示文摘Due to global climate change,Dendrolimus pests and diseases seriously threaten the protec-tion of forestry plants and the safety of crops all over the world.This paper aims to discuss the research results and frontier progress of Dendrolimus disasters based on remote sensing monitoring,trying to find the occurrence characteristics of pests.In this paper,bibliometric methods and CiteSpace knowledge graphs were used to analyze the publication trend,highly cited documents,key research institutions,and high-frequency keywords of the extracted documents in the Web of Science(WOS)database.The following conclusions are drawn:(1)The amount of research in WOS is on the rise,but it has declined in recent years.The countries with strong influence in national cooperation are mainly the United States and China.(2)The United States Department of Agriculture-Agricultural Research Service(USDA ARS)and the Chinese Academy of Sciences have published a lot.This paper reviewed the research progress of high-frequency institutions.(3)The key research topics focus on remote sensing,agriculture,and environmental sciences.Besides,the research hotspots include remote sensing monitoring,climate change,spectral reflectance,vegetation index,and precision agriculture.Finally,we put forward the current challenges and development trends of remote sensing pest monitoring.This paper can provide a reference for the research on remote sensing monitoring of Dendrolimus disasters in the future. | WANG Mingchang ZHOU Yuyang LI Mingjie JI Xue LIU Ziwei | 2022 | Global Geology2022，25，1： | 0 |
| 17 | Aryl C–H iodination: are there actual flavin-dependent iodinases in nature?显示文摘Flavin-dependent halogenases (FDHs) are well known to introduce carbon halide bonds (mainly C–Cl and C–Br) into natural products with the assistance of a partner protein flavin reductase to generate reduced flavin (FADH_(2)or FMNH_(2)).Compared with the common chloride-and bromide-containing natural products (approximately 5,000 compounds),iodinated natural products(approximately 100 compounds) are very limited.Specific iodinases have also rarely been identified in nature to date.This study discovered a novel relationship between iodination and flavin reductases for the first time.Through mechanistic studies,it was identified that peroxide (H_(2)O_(2)) was released from the uncoupling reaction of flavin reductases and then reacted with iodide ions(I^(-)) to produce hypoiodous acid (IOH) for the final iodination.Furthermore,this study also unintentionally verified that the recently reported flavin-dependent iodinase Vir X1 from the marine virus and its two homologs (MBG and NCV) did not catalyze iodination in the in vitro biochemical system but likely belonged to a new phylogenetic clade in the tryptophan halogenase superfamily.As a consequence,actual flavin-dependent iodinases in nature remain to be discovered by the scientific community in the future. | Yuyang Zhang Lin Chen Hongping Chen Tingting Huang Qing Shi Xiaozheng Wang Yan Wang Man-Cheng Tang Ning-Yi Zhou Shuangjun Lin | 2021 | Science China Chemistry2021，64，10： | 0 |
| 18 | Length matters:Scalable fast encrypted internet traffic service classification based on multiple protocol data unit length sequence with composite deep learning显示文摘As an essential function of encrypted Internet traffic analysis,encrypted traffic service classification can support both coarse-grained network service traffic management and security supervision.However,the traditional plaintext-based Deep Packet Inspection(DPI)method cannot be applied to such a classification.Moreover,machine learning-based existing methods encounter two problems during feature selection:complex feature overcost processing and Transport Layer Security(TLS)version discrepancy.In this paper,we consider differences between encryption network protocol stacks and propose a composite deep learning-based method in multiprotocol environments using a sliding multiple Protocol Data Unit(multiPDU)length sequence as features by fully utilizing the Markov property in a multiPDU length sequence and maintaining suitability with a TLS-1.3 environment.Control experiments show that both Length-Sensitive(LS)composite deep learning model using a capsule neural network and LS-long short time memory achieve satisfactory effectiveness in F1-score and performance.Owing to faster feature extraction,our method is suitable for actual network environments and superior to state-of-the-art methods. | Zihan Chen Guang Cheng Ziheng Xu Shuyi Guo Yuyang Zhou Yuyu Zhao | 2022 | Digital Communications and Networks2022，8，3： | 0 |
| 19 | Regulation of Zishen Qinggan( Shuangyi) Prescription to Insulin Resistance of GK Rats显示文摘[Objective] To study the effects of Zishen Qinggan( Shuangyi) Prescription on blood glucose,Hb A1c( glycosylated hemoglobin A1c),C-peptide( C-P),glucagon-like peptide( GLP-1),and α-glucosidase activity in GK( Goto-Kakizaki) rats. [Methods]Selected fasting blood glucose( FBG) > 11. 1mmol/L GK rats and randomly divided into groups: model group,Zishen Qinggan( Shuangyi) Prescription low dosage( ig,400 mg/kg/d),medium dosage( ig,800 mg/kg/d),and high dosage groups( ig,1600 mg/kg/d),and metformin group(ig,85 mg/kg/d). After continuous administration for 28 d,fasting blood glucose(FBG),oral glucose tolerance test(OGTT),Hb A1 c,C-P,GLP-1 and α-glucosidase activity were detected. [Results] Compared with the control group,FBG and Hb A1 c of the model group was significantly higher( P < 0. 01); compared with the model group,Zishen Qinggan( Shuangyi) Prescription could significantly reduce the levels of blood glucose,Hb A1 c,and the elevated blood glucose levels after 120 min of glucose loading in OGTT( P < 0. 05,P < 0. 01),and also can significantly improve the level of C-P,GLP-1( P < 0. 05,P < 0. 01),reduce Homa-IR,and inhibit α-glucosidase activity. [Conclusions]Zishen Qinggan( Shuangyi) Prescription can effectively reduce the blood glucose of GK rats,the action mechanism of which is possibly that it can improve insulin resistance,increase GLP-1 content and inhibit α-glucosidase activity. | Chunyu TIAN Chen XING Haimei BO Liang ZHU Xiaojin LA Huijuan CAO Xin YAN Yuyang YANG Xuemei ZHOU Ji'an LI Yongsen JIA | 2017 | Medicinal Plant2017，8，3： | 0 |
| 20 | A Sustainable Dual Cross‑Linked Cellulose Hydrogel Electrolyte for High‑Performance Zinc‑Metal Batteries显示文摘Aqueous rechargeable Zn-metal batteries(ARZBs)are considered one of the most promising candidates for grid-scale energy storage.However,their widespread commercial application is largely plagued by three major challenges:The uncontrollable Zn dendrites,notorious parasitic side reactions,and sluggish Zn^(2+)ion transfer.To address these issues,we design a sustainable dual crosslinked cellulose hydrogel electrolyte,which has excellent mechanical strength to inhibit dendrite formation,high Zn^(2+)ions binding capacity to suppress side reaction,and abundant porous structure to facilitate Zn^(2+)ions migration.Consequently,the Zn||Zn cell with the hydrogel electrolyte can cycle stably for more than 400 h under a high current density of 10 mA cm^(−2).Moreover,the hydrogel electrolyte also enables the Zn||polyaniline cell to achieve high-rate and long-term cycling performance(>2000 cycles at 2000 mA g^(−1)).Remarkably,the hydrogel electrolyte is easily accessible and biodegradable,making the ARZBs attractive in terms of scalability and sustainability. | Haodong Zhang Xiaotang Gan Yuyang Yan Jinping Zhou | 2024 | Nano-Micro Letters2024，16，6： | 0 |
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