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| 1 | 澳大利亚旅游网站信息流对旅游人流的导引:过程、强度和机理问题显示文摘这篇文章以澳大利亚旅游网站为对象,研究旅游网站信息流导引旅游人流的若干问题,旨在证实虚拟流动对现实流动的作用性。文章首先分析了旅游信息流因素的变化;而后透视了基于旅游网站功能性与服务性的信息流对旅游人流导引的过程;再后给出了旅游网站信息流对不同类型旅游人流导引的强度,最后从旅游网站使用比和旅游网站信息比两个方面揭示了旅游网站对旅游人流导引的机理。 | 路紫 刘娜 Zui Z | 2007 | 人文地理2007，22，5： | 71 |
| 2 | Natural compounds from traditional medicinal herbs in the treatment of cerebral ischemia/reperfusion injury显示文摘药发现的地里的越来越多的注意从传统的药用的植物集中于自然混合物的 neuroprotection。服的局部缺血是包含一系列机制的一个复杂病理学的过程,并且为从传统的植物药的 neuroprotectants 的发展的一个框架是为服的局部缺血的有希望的治疗。有反氧化,反发炎,钙 antagonization, anti-apoptosis,和 neurofunctional 规定的效果的自然混合物在试验性的 ischemic 大脑损害上展出预防或治疗学的效果。根据位于 neuroprotection 下面的药理学机制,我们从在 ischemic 大脑损害上展出保护的效果的传统的药用的植物评估了自然产品并且描绘了有希望的目标。 | Peng-fei WU Zui ZHANG Fang WANG Jian-guo CHENI | 2010 | Acta Pharmacologica Sinica2010，31，12： | 38 |
| 3 | Targeting calcium signaling in cancer therapy显示文摘The intracellular calcium ions(Ca^(2+)) act as second messenger to regulate gene transcription,cell proliferation, migration and death. Accumulating evidences have demonstrated that intracellular Ca^(2+)homeostasis is altered in cancer cells and the alteration is involved in tumor initiation, angiogenesis,progression and metastasis. Targeting derailed Ca^(2+)signaling for cancer therapy has become an emerging research area. This review summarizes some important Ca^(2+)channels, transporters and Ca^(2+)-ATPases,which have been reported to be altered in human cancer patients. It discusses the current research effort toward evaluation of the blockers, inhibitors or regulators for Ca^(2+)channels/transporters or Ca^(2+)-ATPase pumps as anti-cancer drugs. This review is also aimed to stimulate interest in, and support for researchinto the understanding of cellular mechanisms underlying the regulation of Ca^(2+)signaling in different cancer cells, and to search for novel therapies to cure these malignancies by targeting Ca^(2+)channels or transporters. | Chaochu Cui Robert Merritt Liwu Fu Zui Pan | 2017 | Acta Pharmaceutica Sinica B2017，7，1： | 32 |
| 4 | Postreperfusion syndrome during orthotopic liver transplantation:a single-center experience显示文摘BACKGROUND: Marked hemodynamic alteration, commonly referred to as postreperfusion syndrome (PRS), often occurs after revascularization of the donor organ during orthotopic liver transplantation (OLT) and is associated with poor outcomes. This study aimed to investigate the incidence, predictive factors and clinical outcomes of PRS in Chinese patients following OLT at a liver transplantation center in China. METHODS: Over a 5-year period, 330 consecutive patients who had undergone OLT for hepatocellular carcinoma or cirrhosis were included in this retrospective study. PRS was defined as a >30% decrease in the mean arterial pressure compared with that before revascularization for more than 1 minute during the first 5 minutes of graft reperfusion. The patients were divided into 2 groups according to the development of PRS: group 1 (patients with PRS, n=56) and group 2 (patients without PRS, n=274). The demographic characteristics, operative and postoperative courses, and outcomes of the patients were analyzed using SPSS version 18.0. RESULTS: Multivariate regression analysis showed that left ventricular diastolic dysfunction determined by echocardiography and prolonged cold ischemia time were the independent risk factors for PRS. More patients in group 1 showed postoperative renal dysfunction than those in group 2 (19.23% vs 8.4%). Moreover, patients in group 1 also had higher intraoperative (7.14% vs 0%) and postoperative mortalities (26.92% vs 12.04%).CONCLUSION: Left ventricular diastolic dysfunction and prolonged cold ischemia time contribute to a high incidence of PRS, which is associated with adverse outcomes in Chinese patients following OLT. | Zhen-Dong Xu, Hai-Tao Xu, Hong-Bin Yuan, Hao Zhang, Rui-Hua Ji, Zui Zou, Zhi-Ren Fu and Xue-Yin Shi Department of Anesthesiology, Huashan Hospital, Fudan University, Shanghai 200040, China Department of Anesthesiology Organ Transplantation Center , Changzheng Hospital, Second Military Medical University, Shanghai 200003, China | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，1： | 15 |
| 5 | Time-domain analysis methodology for large-scale RLC circuits and its applications显示文摘With soaring work frequency and decreasing feature sizes, VLSI circuits with RLC parasitic components are more like analog circuits and should be carefully analyzed in physical design. However, the number of extracted RLC components is typically too large to be analyzed efficiently by using present analog circuit simulators like SPICE. In order to speedup the simulations without error penalty, this paper proposes a novel methodology to compress the time-descritized circuits resulted from numerical integration approximation at every time step. The main contribution of the methodology is the efficient structure-level compression of DC circuits containing many current sources, which is an important complement to present circuit analysis theory. The methodology consists of the following parts: 1) An approach is proposed to delete all intermediate nodes of RL branches. 2) An efficient approach is proposed to compress and back-solve parallel and serial branches so that it is error-free and of linear complexity to analyze circuits of tree topology. 3) The Y toπtransformation method is used to error-free reduce and back-solve the intermediate nodes of ladder circuits with the linear complexity. Thus, the whole simulation method is very accurate and of linear complexity to analyze circuits of chain topology. Based on the methodology, we propose several novel algorithms for efficiently solving RLC-model transient power/ground (P/G) networks. Among them, EQU-ADI algorithm of linear-complexity is proposed to solve RLC P/G networks with mesh-tree or mesh-chain topologies. Experimental results show that the proposed method is at least two orders of magnitude faster than SPICE while it can scale linearly in both time- and memory-complexity to solve very large P/G networks. | LUO Zuying CAI Yici Sheldon X.-D Tan HONG Xianlong WANG Xiaoyi PAN Zhu FU Jingjing | 2006 | Science in China(Series F)2006，49，5： | 13 |
| 6 | Zinc deficiency and cellular oxidative stress: prognostic implications in cardiovascular diseases显示文摘锌是为人的健康的必要营养素并且有抗氧化的应力和反煽动性的功能。在锌缺乏和心血管的疾病(CVD ) 的发展之间的协会被众多的研究支持了。补充锌能减少动脉粥样硬化的风险并且免于心肌的梗塞和 ischemia/reperfusion 损害。在这评论,我们在文学总结证据,在 CVD 在锌动态平衡的 dysregulation 上巩固当前的知识,并且探索锌的重要角色在心脏的生理学和 pathophysiology 的动态平衡规章的蛋白质。而且,这评论也在 CVD 在锌 / 锌的潜在的诊断、预示的含意上商讨联系动态平衡的分子(压缩, ZnT,和 MT ) 。 | Sangyong CHOI Xian LIU Zui PAN | 2018 | Acta Pharmacologica Sinica2018，39，7： | 12 |
| 7 | Negative reflection and negative surface wave conversion from obliquely incident electromagnetic waves显示文摘Complete control of spatially propagating waves(PWs)and surface waves(SWs)is an ultimate goal that scientists and engineers seek for,in which negative reflection of PW and negative surface wave are two exotic phenomena.Here,we experimentally demonstrate an anisotropic digital coding metasurface capable of controlling both PWs and SWs with a single coding pattern.On the basis of the digital description of coding metasurfaces,a simple coding method is proposed to allow dual functionalities(either PW or SW manipulations)under two orthogonal polarizations at arbitrarily oblique incidences,thus improving the adaptability of digital coding metasurfaces in more practical circumstances.With elaborately designed ellipse-shaped coding particles,we experimentally demonstrate various functions under oblique incidences,including the negative reflection of PW,negative SW,anomalous reflection and their arbitrary combinations,all having good agreements with theoretical and numerical predictions.We believe that the proposed method may enable the digital coding metasurfaces to have broad applications in radar detections,wireless communications and imaging. | Shuo Liu Tie Jun Cui Ahsan Noor Zui Tao Hao Chi Zhang Guo Dong Bai Yan Yang Xiao Yang Zhou | 2018 | Light(Science & Applications)2018，7，1： | 10 |
| 8 | MicroRNA-4661 inhibits antiviral innate immune response by targeting interferon-alpha显示文摘 | Yingke Li Xiaohua Fan Xingying He Haijing Sun Zui Zou Hongbin Yuan Haitao Xu Chengcai Wang Xueyin Shi | 2012 | Cellular & Molecular Immunology2012，9，6： | 8 |
| 9 | HPLC and LC-MS analysis of sinomenine and its application in pharmacokinetic studies in rats显示文摘 | Li-hong LONG Peng-fei WU Xiang-Iong CHEN Zui ZHANG Yu CHEN Yi-yong LI You JIN Jian-guo CHEN Fang WANG | 2010 | Acta Pharmacologica Sinica2010，31，11： | 8 |
| 10 | Protective effects of hydroxyethyl starch 130/0.4 against myocardial ischemia/reperfusion injury in rats显示文摘背景损害和它的机制是的心肌的 ischemia/reperfusion ( I/R )上的 hydroxyethyl 淀粉 130/0.4 ( HES130/0.4 )的效果这研究的 uncertain.The 目的是在 48 只 Sprague-Dawley 老鼠被分到假冒操作的组( S 组)的心肌的 I/R injury.Methods 上调查 HES 130/0.4 的保护的效果, ischemia-reperfusion 组( I/R 组), albumin-I/R 组( A-I/R 组)和 HES130/0.4-I/R 组织( H-I/R 组) .The 液体在ischemia.H-I/以后在 25 | SUN Hai-jing LI Hao ZOU Zui SHI Xue-yin | 2011 | Chinese Medical Journal2011，，2： | 7 |
| 11 | A new geographical language: A perspective of GIS显示文摘语言在通讯起一个重要作用,分享并且在人之中的信息的传播。地理语言为理解是必要的,调查,表示并且宣传 geo 空间的信息。地理语言在科学,技术和认知层次与改进逐渐地发展了并且演变。有关从地理信息本体论,认识论和语言学理论的理论进步,这份报纸第一提出一种 GIS 语言的概念并且在地理语言的结构,功能和特征根据变化讨论它的基本特征。这种 GIS 语言能被认为是合成数字符号的一个系统。它是地理目标,现象和他们的空间分布和动态过程的一个全面代表。这个代表帮助我们与几何学,地位,进程,时间空间的关系,语义和属性用地理情形或符号产生地理空格的一种通用感觉。而且,这份报纸声明 GIS 语言由于它的内在的特征,结构,功能和系统的内容代表地理语言的新一代。基于上述的理论基础,这份报纸从地理研究人员的观点说明 GIS 语言的枢轴的地位和贡献。GIS 的语言是为当前的时代设计的一种新地理语言,与包括时间空间的多尺寸表示,交互可视化,虚拟地理情形,多传感器感觉并且经由网的有用广播的特征。GIS 语言是迄今为止开发的高度级的地理语言,集成语义定义,特征抽取,地理动态表示和时间空间的因素并且统一地理现象和目标的计算。GIS 语言拥有五个重要特征:抽象,系统,严格,精确和层次。在摘要, GIS 语言提供一个新工具让人认出,理解并且模仿全部 geo 环境。因此,在当代的地理开发的 GIS 语言功能的探索正在变得日益重要。同样,概念的模型的建设和 GIS 语言的科学系统将支持地理和地理信息科学的学科的开发。因此,这份报纸从数字技术,地理标准,地理建模和地理的纪律发展的观点调查 GIS 语言的前景。 | HU Zui TANG Guoan LU Guonian | 2014 | Journal of Geographical Sciences2014，24，3： | 7 |
| 12 | Open Sesame: treasure in store-operated calcium entry pathway for cancer therapy显示文摘Store-operated Ca2+ entry(SOCE) controls intracellular Ca2+ homeostasis and regulates a wide range of cellular events including proliferation,migration and invasion.The discovery of STIM proteins as Ca2+ sensors and Orai proteins as Ca2+ channel pore forming units provided molecular tools to understand the physiological function of SOCE.Many studies have revealed the pathophysiological roles of Orai and STIM in tumor cells.This review focuses on recent advances in SOCE and its contribution to tumorigenesis.Altered Orai and/or STIM functions may serve as biomarkers for cancer prognosis,and targeting the SOCE pathway may provide a novel means for cancer treatment. | PAN Zui MA JianJie | 2015 | Science China(Life Sciences)2015，58，1： | 6 |
| 13 | Efficient statistical analysis method of power/ground (P/G) network显示文摘In this paper,we propose an incremental statistical analysis method with complexity reduction as a pre-process for on-chip power/ ground (P/G) networks. The new method exploits locality of P/G network analyses and aims at P/G networks with a large number of strongly connected subcircuits (called strong connects) such as trees and chains. The method consists of three steps. First it compresses P/ G circuits by removing strong connects. As a result,current variations (CVs) of nodes in strong connects are transferred to some remain-ing nodes. Then based on the locality of power grid voltage responses to its current inputs,it effciently calculates the correlative resistor (CR) matrix in a local way to directly compute the voltage variations by using small parts of the remaining circuit. Last it statistically recovers voltage variations of the suppressed nodes inside strong connects. This new method for statistically compressing and expanding strong connects in terms of current or voltage variations in a closed form is very effcient owning to its property of incremental analysis. Experimental results demonstrate that the method can effciently compute low-bounds of voltage variations for P/G networks and it has two or three orders of magnitudes speedup over the traditional Monte-Carlo-based simulation method,with only 2.0% accuracy loss. | Zuying Luo Sheldon X.D. Tan | 2008 | Progress in Natural Science:Materials International2008，18，2： | 5 |
| 14 | The transmembrane domain of TACE regulates protein ectodomain shedding显示文摘众多的膜蛋白质被变换酶的肿瘤坏死 factor-alpha 劈开(不作声) ,它引起他们的 ectodomains 的版本。ADAM (一个 disintegrin 和 metalloprotease 领域) 家庭成员,不作声包含谁的几个非催化的领域在流的 ectodomain 的角色还得充分被解决。这里,我们探索了 transmembrane 领域(TM ) 的功能由联合分子的工程和功能的分析不作声。一 TM 免费不作声被有约束力的多肽没能恢复转变生长 factor-alpha (TGF-alpha ) 流的 glycosylphosphatidylinositol (GPI ) 抛锚到血浆膜的构造,肿瘤坏死 factor-alpha (TNF-alpha ) 和在细胞缺乏的 L-selectin 内长不作声活动。有催乳激素受体或导出血小板的生长因素受体(PDGFR ) 的 TACE TM 的替换也导致了流的 TGF-alpha 的严重损失,但是没在 TNF-alpha 和 L-selectin 的劈开上有效果。在有 L-selectin 的 TGF-alpha 的 TM 的代替启用了由带催乳激素受体和 PDGFR 的 TM 的 TACE 异种流的 TGF-alpha。总起来说,我们的观察建议那个抛锚通过 TM 不作声到类脂化合物双性人层为许多底层的有效劈开被要求,并且氨基酸的顺序不作声 TM 可以在规章的特性起一个作用在之中不作声底层。 | Xiaojin Li Liliana Pére Zui Pan Huizhou Fan | 2007 | Cell Research2007，17，12： | 5 |
| 15 | First experimental constraints on WIMP couplings in the effective field theory framework from CDEX显示文摘We present weakly interacting massive particles(WIMPs) search results performed using two approaches of effective field theory from the China Dark Matter Experiment(CDEX), based on the data from both CDEX-1B and CDEX-10 stages. In the nonrelativistic effective field theory approach, both time-integrated and annual modulation analyses were used to set new limits for the coupling of WIMP-nucleon effective operators at 90% confidence level(C.L.) and improve over the current bounds in the low mχregion. In the chiral effective field theory approach, data from CDEX-10 were used to set an upper limit on WIMP-pion coupling at 90% C.L. We for the first time extended the limit to the m_(χ)<6 GeV/c^(2) region. | Yi Wang Zhi Zeng Qian Yue LiTao Yang KeJun Kang YuanJing Li Mehment Agartioglu HaiPeng An JianPing Chang JingHan Chen YunHua Chen JianPing Cheng Cheng Yi Chiang WenHan Dai Zhi Deng ChangHao Fang XinPing Geng Hui Gong QiuJu Guo XuYuan Guo HongJian He Li He ShengMing He JinWei Hu TuChen Huang HanXiong Huang HaiTao Jia LiPing Jia Xi Jiang HauBin Li JianMin Li Jin Li MingXuan Li RenMingJie Li Xia Li YuLan Li Bin Liao FongKay Lin ShinTed Lin ShuKui Liu YanDong Liu Yu Liu YuanYuan Liu ZhongZhi Liu Hao Ma YuCai Mao QiYuan Nie JinHua Ning Hui Pan NingChun Qi Jie Ren XiChao Ruan ChangSong Shang Vivek Sharma Ze She Lakhwinder Singh Monoj Kumar Singh TianXi Sun ChangJian Tang WeiYou Tang Yang Tian GuangFu Wang Li Wang Qing Wang Yu Chen Wang YunXiang Wang Zhen Wang Henry Tsz-King Wong ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue YuLu Yan Nan Yi ChunXu Yu HaiJun Yu JianFeng Yue Ming Zeng BingTao Zhang Lei Zhang FengShou Zhang ZhenYu Zhang KangKang Zhao MingGang Zhao JiFang Zhou ZuYing Zhou JingJun Zhu | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，8： | 3 |
| 16 | First results on ^(76)Ge neutrinoless double beta decay from CDEX-1 experiment显示文摘We report the first results on ^(76)Ge neutrinoless double beta decay from stage one of the China dark-matter experiment(CDEX).A p-type point-contact high-purity germanium detector with a mass of 994 g has been installed to detect neutrinoless double beta decay events, as well as to directly detect dark matter particles. An exposure of 304 kg d has been analyzed over a wide spectral band from 500 keV to 3 MeV. The average event rate obtained was about 0.012 counts per keV per kg per day over the 2.039 MeV energy range. The half-life of ^(76)Ge neutrinoless double beta decay derived based on this result is T^(0ν)1/2>6.4×10^(22) yr(90% C.L.). An upper limit on the effective Majorana-neutrino mass of 5.0 eV has been achieved. | Li Wang Qian Yue KeJun Kang JianPing Cheng YuanJing Li TszKing Henry Wong ShinTed Lin JianPing Chang JingHan Chen QingHao Chen YunHua Chen Zhi Deng Qiang Du Hui Gong Li He QingJu He JinWei Hu HanXiong Huang TengRui Huang LiPing Jia Hao Jiang HauBin Li Hong Li JianMin Li Jin Li Jun Li Xia Li XueQian Li YuLan Li FongKay Lin ShuKui Liu Hao Ma JingLu Ma XingYu Pan Jie Ren XiChao Ruan ManBin Shen Vivek Sharma Lakhwinder Singh Manoj Kumar Singh Manoj Kumar Singh Arun Kumar Soma ChangJian Tang WeiYou Tang ChaoHsiung Tseng JiMin Wang Qing Wang ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue LiTao Yang SongWei Yang Nan Yi ChunXu Yu HaiJun Yu WeiHe Zeng XiongHui Zeng Zhi Zeng Lan Zhang YunHua Zhang MingGang Zhao Wei Zhao JiFang Zhou ZuYing Zhou JingJun Zhu WeiBin Zhu ZhongHua Zhu | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，7： | 3 |
| 17 | 初拱变形对CRTSⅡ型板式轨道高温稳定性影响研究(英文)显示文摘目的:初拱变形是影响CRTSⅡ型板式轨道垂向稳定性的关键因素之一。通过建模分析,深入研究初拱变形的不同特征量,即矢度、弦长和线型,对其受力变形及高温稳定性的影响。方法:基于变波长变形曲线建立CRTSⅡ型板垂向稳定性分析理论,开展缩尺模型试验验证,并通过有限元法进行计算仿真。结论:有限元法、解析法与现场试验所得垂向上拱位移的变化趋势一致,有限元法与解析法结果吻合更好。轨道板初拱弦长为6.5m且初拱矢度超过15 mm时,拱顶处下缘混凝土最易发生受压破坏。在高温环境下,初拱弦长为6.5m的轨道板上拱矢跨比最大。拱顶存在折角、初拱段边界平滑的轨道板在高温环境下更容易保持原有形态,但后者于拱顶处下缘的混凝土更容易发生受压破坏。故为确保CRTS Ⅱ型板的稳定性,应避免弦长达到6.5 m且矢度超过15 mm的初始上拱,另需关注不同初拱线型对轨道板上拱的影响。 | Zui CHEN Jie-ling XIAO Xiao-kai LIU Xue-yi LIU Rong-shan YANG Juan-juan REN | 2018 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2018，19，12： | 3 |
| 18 | Adeno-associated virus vectors simultaneously encoding VEGF and angiopoietin-1 enhances neovascularization in ischemic rabbit hindlimbs显示文摘目的: Angiopoietin-1 ( Ang1 )和脉管的 endothelial 在脉管的形成和成熟的生长因素 A ( VEGF ) playimportant 角色,建议 2 将是的这的联合为我们构造了的 ischemic diseases.So 的 apromising 治疗 adeno-associatedvirus ( AAV )向量,同时编码的人的 VEGF165 和 Angl ( AAV-VEGF/Ang1 ),并且在兔子 ischemic 调查了 itstherapeutic 效果后部手足的 model.Methods :四个试验性的组是 usedto 准备兔子 ischemic 后部手足的模型追随者 AAV | Feng CHEN Zui TAN Chang-yuan DONG Xiao CHEN Shu-fang GUO | 2007 | Acta Pharmacologica Sinica2007，28，4： | 3 |
| 19 | Optimization of ultrasound-assisted extraction of camptothecin from Camptotheca acuminata seeds显示文摘Naturally occurring camptothecin(CPT) is an important source of chemotherapeutic agents.The extraction from Camptotheca acuminata is still the main approach to obtain CPT compared with total synthesis.In the present study,ultrasound-assisted extractions(UAE) of CPT from C.acuminata seeds with alkaline solutions were investigated and CPT yield were determined by High Performance Liquid Chromatography.The conditions of alkaline species and concentrations,extraction time,extraction temperature and ultrasonic power were optimized.Results show that both Na3PO4 and Na2CO3 solutions gain good extraction yields,whereas Na3PO4 solution has stronger basicity and need higher concentration than Na2CO3 solution does,thus aqueous Na2CO3 is more beneficial for the extraction.The optimal condition was ultrasonically extracted with 0.5% aqueous Na2CO3 at 50°C and ultrasonic power of 400 W for 60 min.Comparing with UAE with ethanol,the extraction with 0.5% Na2CO3 solution achieves higher yield.Moreover,aqueous Na2CO3 as a solvent has various advantages including non-toxicity,inflammable,non-corrosive and low cost,which ensure this UAE method is a superior method with high utilizing prospect. | JING Li-jia LI Si-yang CHANG Zui WANG Yang YAN Xiu-feng | 2011 | Journal of Forestry Research2011，22，2： | 2 |
| 20 | 菌群对于胃癌和食管癌患者免疫环境及免疫治疗的影响显示文摘胃癌和食管癌的发生是多因素多阶段的。尽管肠道菌群对人体健康和疾病的影响已广为报道,但胃/食管菌群对于胃癌和食管癌的影响仍不明了。本文综述了胃/食管菌群在正常生理及病理状态下的组成变化,以及菌群失调在肿瘤发生中的潜在作用。同时还探讨了胃/食管菌群失调是如何刺激局部及全身免疫,从而影响胃癌和食管癌的免疫治疗。 | Xiaoli Zhang Zui Pan | 2020 | Gastroenterology Report2020，8，3： | 2 |
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