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| 1 | QTL analysis of the rice seedling cold tolerance in a double haploid population derived from anther culture of a hybrid between indica and japonica rice显示文摘A doubled haploid population, derived from anther culture of F hybrid between a typical indica cv. and a japonica cv. has been used to investigate the seedling cold tolerance (SCT) in growth cabinet. By dynamically analyzing every day’s survival percentages of the parents and DH lines under 7-d cold plus 9-d normal temperature condition, the guantitative trait loci (QTLs) for SCT have been mapped based on a molecular linkage map constructed from this population. The results show that two parents had significant differences in SCT and the segregation of SCT in DH lines was basically a continuous distribution with most serious injury on the 6th d of the cold treatment. A total of 4 QTLs for SCT have been identified on chromosomes 1, 2, 3 and 4 respectively. The additive effects of qSCT-1, qSCT-2 and qSCT-3 have been contributed by the japonica ev JX17, but that of qSCT-4 has been contributed by the indica cv ZYQ8. The mechanism of SCT seems complicated since the above 4 QTLs detected at different stages | QIAN Qian ZENG Dali HE Ping ZHENG Xianwu CHEN Ying ZHU Lihuang | 2000 | Chinese Science Bulletin2000，45，5： | 18 |
| 2 | Increasing targeting scope of adenosine base editors in mouse and rat embryos through fusion of TadA deaminase with Cas9 variants显示文摘 | Lei Yang Xiaohui Zhang Liren Wang Shuming Yin Biyun Zhu Ling Xie Qiuhui Duan Huiqiong Hu Rui Zheng Yu Wei Liangyue Peng Honghui Han Jiqin Zhang Wenjuan Qiu Hongquan Geng Stefan Siwko Xueli Zhang Mingyao Liu Dali Li | 2018 | Protein & Cell2018，9，9： | 13 |
| 3 | Circulating tumor DNA 5-hydroxymethylcytosine as a novel diagnostic biomarker for esophageal cancer显示文摘 | Xin Tian Baofa Sun Chuanyuan Chen Chunchun Gao Ji Zhang XingYu Lu Linchen Wang Xiangnan Li Yurong Xing Ruijuan Liu Xiao Han Zheng Qi Xiaojian Zhang Chuan He Dali Han Yun-Gui Yang Quancheng Kan | 2018 | Cell Research2018，28，5： | 12 |
| 4 | Xa7, a new executor R gene that confers durable and broad-spectrum resistance to bacterial blight disease in rice显示文摘Bacterial blight(BB)is a globally devastating rice disease caused by Xanthomonas oryzae pv.oryzae(Xoo).The use of disease resistance(R)genes in rice breeding is an effective and economical strategy for the control of this disease.Nevertheless,a majority of R genes lack durable resistance for long-term use under global warming conditions.Here,we report the isolation of a novel executor R gene,Xa7,that confers extremely durable,broad-spectrum,and heat-tolerant resistance to Xoo.The expression of Xa7 was induced by incompatible Xoo strains that secreted the transcription activator-like effector(TALE)AvrXa7 or PthXo3,which recognized effector binding elements(EBEs)in the Xa7 promoter.Furthermore,Xa7 induction was faster and stronger under high temperatures.Overexpression of Xa7 or co-transformation of Xa7 with avrXa7 triggered a hypersensitive response in plants.Constitutive expression of Xa7 activated a defense response in the absence of Xoo but inhibited the growth of transgenic rice plants.In addition,analysis of over 3000 rice varieties showed that the Xa7 locuswas found primarily in the indica and aus subgroups.A variation consisting of an 11-bp insertion and a base substitution(G to T)was found in EBEAvrXa7 in the tested varieties,resulting in a loss of Xa7 BB resistance.Through a decade of effort,we have identified an important BB resistance gene and characterized its distinctive interaction with Xoo strains;these findings will greatly facilitate research on the molecular mechanism of Xa7-mediated resistance and promote the use of this valuable gene in breeding. | Xifeng Chen Pengcheng Liu Le Mei Xiaoling He Long Chen Hui Liu Shurong Shen Zhandong Ji Xixi Zheng Yuchen Zhang Zhenyu Gao Dali Zeng Qian Qian Bojun Ma | 2021 | Plant Communications2021，2，3： | 9 |
| 5 | Characterization and Fine Mapping of the ibf Mutant in Rice显示文摘颜料是在植物开发的一个重要字符。在现在的学习,我们在米饭(Oryzasativa L.) 为棕色的沟基因(ibf ) 描绘了,罚款印射一个禁止者。在 ibf 异种,当种子成熟并且在干燥种子到达最大的水平,棕色的颜料明确地在壳的沟积累。Geneticanalysis 证明变异的显型被一后退的核基因控制,它最后长在 90-kb 区域在被印射染色体 9 的手臂。聚合酶链反应和在在异种的 90-kb 区域有 26 kb 删除的南部的弄污 anaiysisrevealed。自从所有,在限定的区域的开的读物 framesoutsidethe 差距没与 thewild 类型在脱氧核糖核酸顺序有可检测的差别,我们要求了 ibf 地点应该位于差距。通过基因注解和颠倒,抄写聚合酶锁住反应(RT-PCR ) 分析,我们选择了编码 akelch 的 OsKF1 包含重复的 F 盒子家庭蛋白质作为 ibf 的候选人基因。 | Jiajun Cui Shengci Fan Tian Shao Zejun Huang Dali Zheng Ding Tang Ming Li Qian Qian Zhukuan Cheng | 2007 | Journal of Integrative Plant Biology2007，49，5： | 7 |
| 6 | Buckling of a ferromagnetic thin plate in a transverse static magnetic field显示文摘An energy theory is proposed on the buckling of a ferromagnetic thin plate in a transverse static magnetic field. The analytic solution of critical field for plates is obtained by using variational method. It is shown that the critical magnetic field is not only influenced by the ratio of the thickness to the length, but also by the width, total length and the magnetic susceptibility of the specimen. Theoretical calculations agree with experiments reasonably. | Wentao Yang Hao Pan Dali Zheng Qigong Cai | 1998 | Chinese Science Bulletin1998，43，19： | 2 |
| 7 | Mn,N co-doped Co nanoparticles/porous carbon as air cathode for highly efficient rechargeable Zn-air batteries Hide Author's Information显示文摘Oxygen reduction reaction(ORR)and oxygen evolution reaction(OER)are generally catalyzed by precious metals(Pt)and metal oxides(IrO_(2))which still have many shortages including expensive price,poor selectivity and undesirable stability.In this work,we report a Mn0-doped CoN_(x) on N-doped porous carbon(Mn-CoN_(x)/N-PC)composite from carbonizing metal-organic framework(MOF)derivative as the dual-functional catalyst to boost both the ORR and OER performances.Owing to the strong coordination effect between nitrogen and metal elements,the introduction of N can obviously improve the content of Co-N-C active sites for ORR.Meanwhile,the Mn-doping significantly regulates the electronic structure of the Co element and increases the content of Co^(0) which provide efficient OER active sites.Mn-CoN_(x)/N-PC catalyst delivers super dual-functional activity with a half-wave potential of 0.85 V,better than the 20%Pt/C catalyst(0.82 V).When used in Zn-air batteries for testing,Mn-CoN_(x)/N-PC electrocatalyst shows a high power density(145 mW·cm^(−2))and good cycle performance. | Hanzhen Zheng Fei Ma Hongcen Yang Xiaogang Wu Rui Wang Dali Jia Zhixia Wang Niandi Lu Fen Ran Shanglong Peng | 2022 | Nano Research2022，15，3： | 2 |
| 8 | Study on new preparing process of β-tricalcium phosphate bioac- tire ceramics with high properties显示文摘 | Zhou Dali Zheng Changqiong Yin Guangfu | 1999 | Journal of Biomed- ical Engineering1999，1，： | 1 |
| 9 | COLD1 Confers Chilling Tolerance in Rice显示文摘 | Yun Ma Xiaoyan Dai Yunyuan Xu Wei Luo Xiaoming Zheng Dali Zeng Yajun Pan Xiaoli Lin Huanhuan Liu Dajian Zhang Jun Xiao Xiaoyu Guo Shujuan Xu Yuda Niu Jingbo Jin Hui Zhang Xun Xu Legong Li Wen Wang Qian Qian Song Ge Kang Chong | 2015 | Cell2015，，6： | 1 |
| 10 | Upregulation of HIF-2α induced by sorafenib contributes to the resistance by activating the TGF-α/EGFR pathway in hepatocellular carcinoma cells显示文摘 | Dali Zhao Bo Zhai Changjun He Gang Tan Xian Jiang Shangha Pan Xuesong Dong Zheng Wei Lixin Ma Haiquan Qiao Hongchi Jiang Xueying Sun | 2014 | Cellular Signalling2014，，： | 1 |
| 11 | The potency of team-basedcare interventions for hypertension:a meta-analysis 显示文摘 | CarterBL Rogers M Daly J Zheng S James PA | 2009 | Arch Intern Med2009，169，： | 1 |
| 12 | Upregulation of HIF-2α induced by sorafenib contributes to the resistance by activating the TGF-α/EGFR pathway in hepatocellular carcinoma cells显示文摘 | Dali Zhao Bo Zhai Changjun He Gang Tan Xian Jiang Shangha Pan Xuesong Dong Zheng Wei Lixin Ma Haiquan Qiao Hongchi Jiang Xueying Sun | 2014 | Cellular Signalling2014，，： | 1 |
| 13 | A novel LED array used for photodynamic therapy (PDT)显示文摘 | Daly SR Zheng F Krouse F | 2003 | SPIE2003，4996，： | 1 |
| 14 | A small interfering ABCE1-targeting RNA inhibits the proliferation andinvasiveness of small cell lung cancer显示文摘 | Bo Huang Ying Gao Dali Tian Maogen Zheng | 2010 | International Journal of Molecular Medicine2010，，： | 1 |
| 15 | A small interfering ABCE1-targeting RNA inhibits the proliferation andinvasiveness of small cell lung cancer显示文摘 | Bo Huang Ying Gao Dali Tian Maogen Zheng | 2010 | International Journal of Molecular Medicine2010，，5： | 1 |
| 16 | Single-dose AAV-based vaccine induces a high level of neutralizing antibodies against SARS-CoV-2 in rhesus macaques显示文摘Dear Editor,Coronavirus disease 2019(COVID-19)is a highly infectious respiratory disease that continues to pose a serious global public health emergency.The disease shows a high infection rate,long incubation period,and rapidly emerging variants,which have led to its rapid spread worldwide(Krammer 2020).Many vaccines have been developed for the control of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the virus responsible for COVID-19,including vaccines based on messenger RNA(mRNA)(Polack et al.2020),viral vectors(Zhu et al.2020),recombinant proteins(Yang et al.2020),and inactivated SARS-CoV-2(Zhang et al.2021). | Dali Tong Mei Zhang Yunru Yang Han Xia Haiyang Tong Huajun Zhang Weihong Zeng Muziying Liu Yan Wu Huan Ma Xue Hu Weiyong Liu Yuan Cai Yanfeng Yao Yichuan Yao Kunpeng Liu Shifang Shan Yajuan Li Ge Gao Weiwei Guo Yun Peng Shaohong Chen Juhong Rao Jiaxuan Zhao Juan Min Qingjun Zhu Yanmin Zheng Lianxin Liu Chao Shan Kai Zhong Zilong Qiu Tengchuan Jin Sandra Chiu Zhiming Yuan Tian Xue | 2023 | Protein & Cell2023，14，1： | 0 |
| 17 | Correction to: Increasing targeting scope of adenosine base editors in mouse and rat embryos through fusion of TadA deaminase with Cas9 variants显示文摘This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/ licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. | Lei Yang Xiaohui Zhang Liren Wang Shuming Yin Biyun Zhu Ling Xie Qiuhui Duan Huiqiong Hu Rui Zheng Yu Wei Liangyue Peng Honghui Han Jiqin Zhang Wenjuan Qiu Hongquan Geng Stefan Siwko Xueli Zhang Mingyao Liu Dali Li | 2019 | Protein & Cell2019，10，9： | 0 |
| 18 | WNT7A promotes tumorigenesis of head and neck squamous cell carcinoma via activating FZD7/JAK1/STAT3 signaling显示文摘Wnt signaling are critical pathway involved in organ development, tumorigenesis, and cancer progression. WNT7A, a member of the Wnt family, remains poorly understood in terms of its role and the underlying molecular mechanisms it entails in head and neck squamous cell carcinoma (HNSCC). According to the Cancer Genome Atlas (TCGA), transcriptome sequencing data of HNSCC, the expression level of WNT7A in tumors was found to be higher than in adjacent normal tissues, which was validated using Real-time RT-PCR and immunohistochemistry. Unexpectedly, overexpression of WNT7A did not activate the canonical Wnt-β-catenin pathway in HNSCC. Instead, our findings suggested that WNT7A potentially activated the FZD7/JAK1/STAT3 signaling pathway, leading to enhanced cell proliferation, self-renewal, and resistance to apoptosis. Furthermore, in a patient-derived xenograft (PDX) tumor model, high expression of WNT7A and phosphorylated STAT3 was observed, which positively correlated with tumor progression.These findings underscore the significance of WNT7A in HNSCC progression and propose the targeting of key molecules within the FZD7/JAK1/STAT3 pathway as a promising strategy for precise treatment of HNSCC. | Qingling Huang Yi Xiao Ting Lan Youguang Lu Li Huang Dali Zheng | 2024 | International Journal of Oral Science2024，16，1： | 0 |
| 19 | Long-term correction of hemophilia B through CRISPR/Cas9 induced homology-independent targeted integration显示文摘CRISPR/Cas9-mediated site-specific insertion of exogenous genes holds potential for clinical applications.However,it is still infeasible because homologous recombination(HR)is inefficient,especially for nondividing cells.To overcome the challenge,we report that a homology-independent targeted integration(HITI)strategy is used for permanent integration of high-specificity-activity Factor IX variant(F9 Padua,R338L)at the albumin(Alb)locus in a novel hemophilia B(HB)rat model.The knock-in efficiency reaches 3.66%,as determined by droplet digital PCR(dd PCR).The clotting time is reduced to a normal level four weeks after treatment,and the circulating factor IX(FIX)level is gradually increased up to 52%of the normal level over nine months even after partial hepatectomy,demonstrating the amelioration of hemophilia.Through primer-extension-mediated sequencing(PEM-seq),no significant off-target effect is detected.This study not only provides a novel model for HB but also identifies a promising therapeutic approach for rare inherited diseases. | Xi Chen Xuran Niu Yang Liu Rui Zheng Lei Yang Jian Lu Shuming Yin Yu Wei Jiahao Pan Ahmed Sayed Xueyun Ma Meizhen Liu Fengxiang Jing Mingyao Liu Jiazhi Hu Liren Wang Dali Li | 2022 | Journal of Genetics and Genomics2022，49，12： | 0 |
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