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| 1 | Extracellular Signal-Regulated Kinase in Nucleus Accumbens Mediates Propofol Self-Administration in Rats显示文摘Clinical and animal studies have indicated that propofol has potential for abuse,but the specific neurobiological mechanism underlying propofol reward is not fully understood.The purpose of this study was to investigate the role of extracellular signal-regulated kinase(ERK) signal transduction pathways in the nucleus accumbens(NAc) in propofol self-administration.We tested the expression of p-ERK in the NAc following the maintenance of propofol self-administration in rats.We also assessed the effect of administration of SCH23390,an antagonist of the D1 dopamine receptor,on the expression of p-ERK in the NAc in propofol self-administering rats,and examined the effects of intra-NAc injection of U0126,an MEK inhibitor,on propofol reinforcement in rats.The results showed that the expression of p-ERK in the NAc increased significantly in rats maintained on propofol,and pre-treatment with SCH23390 inhibited the propofol selfadministration and diminished the expression of p-ERK in the NAc.Moreover,intra-NAc injection of U0126(4 μg/side) attenuated the propofol self-administration.The data suggest that ERK signal transduction pathways coupled with D1 dopamine receptors in the NAc may be involved in the maintenance of propofol self-administration and its rewarding effects. | Benfu Wang Xiaowei Yang Anna Sun Lanman Xu Sicong Wang Wenxuan Lin Miaojun Lai Huaqiang Zhu Wenhua Zhou Qingquan Lian | 2016 | Neuroscience Bulletin2016，32，6： | 12 |
| 2 | Value of diffusion-weighted imaging in distinguishing pancreatic carcinoma from mass-forming chronic pancreatitis: a meta-analysis显示文摘 | Niu Xiangke Sushant Kumar Das Anup Bhetuwal Xiao Yingquan Sun Feng Zeng Lichuan Wang Wenxuan Yang Hanfeng Yang Hanyu | 2014 | Chinese Medical Journal2014，，19： | 11 |
| 3 | Status and distribution of ungulates in Xinjiang,China显示文摘Based on a long-term field investigation and other research results,we reviewed the status and distribution of ungulates in Xinjiang,China. The ungulates in Xinjiang included 19 ungulate species(30 subspecies) from 6 families and 2 orders. Among them,3 species(2 subspecies) relate to Equidae(Perrisodactyla) ,and 16 species(28 subspecies) are from 5 families of Artiodactyla. In this paper,we analyzed the conservation status of most rare and important 13 ungulate species. Firstly,we proposed the protection of genetic diversity of Camelus ferus and the distribution areas of Moschus sifanicus,Procapra przewalskii and Saiga tatarica in Xinjiang. We found that Moschus sifanicus but not Procapra przewalskii distributed in Xinjiang. It was not clear whether the remnant populations of Saiga tatarica existed in Xinjiang and China-Kazakhstan border or not. We discussed that the protection level and rational use of Capra sibirica and enhancing protection level and enlarging monitoring and research projects for Pantholops hodgsoni and Gazella subgutturosa. And we would like to suggest Forestry Department to develop the captive breeding of Tibetan antelope for rational use. In addition,the captive breeding of Cervus elaphus in Xinjiang was reviewed. Local government should lessen strong control to Cervus elaphus because of many breeding centers' establishment. | XingYi GAO WenXuan XU WeiKang YANG David A BLANK JianFang QIAO KeFen XU | 2011 | Journal of Arid Land2011，3，1： | 5 |
| 4 | A Versatile Surface Bioengineering Strategy Based on Mussel-Inspired and Bioclickable Peptide Mimic显示文摘In this work,we present a versatile surface engineering strategy by the combination of mussel adhesive peptide mimicking and bioorthogonal click chemistry.The main idea reflected in this work derived from a novel mussel-inspired peptide mimic with a bioclickable azide group(i.e.,DOPA_(4)-azide).Similar to the adhesion mechanism of the mussel foot protein(i.e.,covalent/noncovalent comediated surface adhesion),the bioinspired and bioclickable peptide mimic DOPA_(4)-azide enables stable binding on a broad range of materials,such as metallic,inorganic,and organic polymer substrates.In addition to the material universality,the azide residues of DOPA_(4)-azide are also capable of a specific conjugation of dibenzylcyclooctyne-(DBCO-)modified bioactive ligands through bioorthogonal click reaction in a second step.To demonstrate the applicability of this strategy for diversified biofunctionalization,we bioorthogonally conjugated several typical bioactive molecules with DBCO functionalization on different substrates to fabricate functional surfaces which fulfil essential requirements of biomedically used implants.For instance,antibiofouling,antibacterial,and antithrombogenic properties could be easily applied to the relevant biomaterial surfaces,by grafting antifouling polymer,antibacterial peptide,and NO-generating catalyst,respectively.Overall,the novel surface bioengineering strategy has shown broad applicability for both the types of substrate materials and the expected biofunctionalities.Conceivably,the“clean”molecular modification of bioorthogonal chemistry and the universality of mussel-inspired surface adhesion may synergically provide a versatile surface bioengineering strategy for a wide range of biomedical materials. | Yu Xiao Wenxuan Wang Xiaohua Tian Xing Tan Tong Yang Peng Gao Kaiqing Xiong Qiufen Tu Miao Wang Manfred FMaitz Nan Huang Guoqing Pan Zhilu Yang | 2020 | Research2020，，1： | 3 |
| 5 | Berlin Green Framework‑Based Gas Sensor for Room‑Temperature and High‑Selectivity Detection of Ammonia显示文摘Ammonia detection possesses great potential in atmosphere environmental protection,agriculture,industry,and rapid medical diagnosis.However,it still remains a great challenge to balance the sensitivity,selectivity,working temperature,and response/recovery speed.In this work,Berlin green(BG)framework is demonstrated as a highly promising sensing material for ammonia detection by both density functional theory simulation and experimental gas sensing investigation.Vacancy in BG framework offers abundant active sites for ammonia absorption,and the absorbed ammonia transfers sufficient electron to BG,arousing remarkable enhancement of resistance.Pristine BG framework shows remarkable response to ammonia at 50–110°C with the highest response at 80°C,which is jointly influenced by ammonia’s absorption onto BG surface and insertion into BG lattice.The sensing performance of BG can hardly be achieved at room temperature due to its high resistance.Introduction of conductive Ti3CN MXene overcomes the high resistance of pure BG framework,and the simply prepared BG/Ti3CN mixture shows high selectivity to ammonia at room temperature with satisfying response/recovery speed. | Tingqiang Yang Lingfeng Gao Wenxuan Wang Jianlong Kang Guanghui Zhao Delong Li Wen Chen Han Zhang | 2021 | Nano-Micro Letters2021，13，4： | 2 |
| 6 | PKC inhibition of sotrastaurin hasantitumor activity in diffuse large B-cell lymphoma via regulating the expression of MCT-1显示文摘MCT-1 (在 T 房间 lymphoma-1 的多重拷贝) ,新奇 oncogene,原来在 T 房间淋巴瘤被识别。最近的研究证明了 MCT-1 高度在 85% 弥漫的大 B 房间淋巴瘤(DLBCL ) 被表示。PKC (蛋白质 kinase C ) 为激活细胞的功能和增长为多重生物学上活跃的物质在信号 transduction 起一个必要作用。在这研究,我们发现 MCT-1 的 mRNA 和蛋白质表示层次显然在在 SUDHL-4 和 OCI-LY8 DLBCL 房间线由 siRNA 将 PKC 击倒以后被减少。在一个剂量依赖者和时间依赖者举止的一个选择 PKC 禁止者, sotrastaurin,有效地禁止的房间增长和导致的房间 apoptosis。同时,我们也观察到房间周期在对待 sotrastaurin 的房间在 G1 阶段被逮捕。另外, MCT-1 在在 vivo 的 sotrastaurin 处理组是下面调整的。而且,我们证明 PKC 禁止者 sotrastaurin 通过调整 MCT-1 的表示潜在地在 DLBCL 房间导致了房间 apoptosis 和房间周期拘捕。我们的数据建议那指向的 PKC 可以是为展出 MCT-1 的高水平的淋巴瘤和相关恶意的一条潜在的治疗学的途径蛋白质。 | Gaomei Chang Jiayi Zheng Wenqin Xiao Shuaikang Chang Qing Wei Huiqun Wu Yi Tao Guang Yang Bingqian Xie Xiucai Lan Yingcong Wang Dandan Yu Liangning Hu Yongsheng Xie Wenxuan Bu Yuanyuan Kong Bojie Dai Jun Hou Jumei Shi | 2018 | Acta Biochimica et Biophysica Sinica2018，50，4： | 2 |
| 7 | Hymecromone:a clinical prescription hyaluronan inhibitor for efficiently blocking COVID-19 progression显示文摘Currently,there is no effective drugs for treating clinically COVID-19 except dexamethasone.We previously revealed that human identical sequences of SARS-CoV-2 promote the COVID-19 progression by upregulating hyaluronic acid(HA).As the inhibitor of HA synthesis,hymecromone is an approved prescription drug used for treating biliary spasm.Here,we aimed to investigate the relation between HA and COVID-19,and evaluate the therapeutic effects of hymecromone on COVID-19.Firstly,HA was closely relevant to clinical parameters,including lymphocytes(n=158;r=−0.50;P<0.0001),C-reactive protein(n=156;r=0.55;P<0.0001),D-dimer(n=154;r=0.38;P<0.0001),and fibrinogen(n=152;r=0.37;P<0.0001),as well as the mass(n=78;r=0.43;P<0.0001)and volume(n=78;r=0.41;P=0.0002)of ground-glass opacity,the mass(n=78;r=0.48;P<0.0001)and volume(n=78;r=0.47;P<0.0001)of consolidation in patient with low level of hyaluronan(HA<48.43 ng/mL).Furthermore,hyaluronan could directly cause mouse pulmonary lesions.Besides,hymecromone remarkably reduced HA via downregulating HAS2/HAS3 expression.Moreover,89%patients with hymecromone treatment had pulmonary lesion absorption while only 42%patients in control group had pulmonary lesion absorption(P<0.0001).In addition,lymphocytes recovered more quickly in hymecromone-treated patients(n=8)than control group(n=5)(P<0.05).These findings suggest that hymecromone is a promising drug for COVID-19 and deserves our further efforts to determine its effect in a larger cohort. | Shuai Yang Yun Ling Fang Zhao Wei Li Zhigang Song Lu Wang Qiuting Li Mengxing Liu Ying Tong Lu Chen Daoping Ru Tongsheng Zhang Kaicheng Zhou Baolong Zhang Peng Xu Zhicong Yang Wenxuan Li Yuanlin Song Jianqing Xu Tongyu Zhu Fei Shan Wenqiang Yu Hongzhou Lu | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 2 |
| 8 | Impact of great gerbils(Rhombomys opimus) on desert plant communities显示文摘Great gerbil(Rhombomys opimus) colonies, with bare soil and herbaceous plants, are conspicuous to the background environment throughout their range area. In order to quantify the engineer role of great gerbils, we investigated the plant communities of 20 active colonies in the Junggar Basin, Xinjiang, China. In areas without disturbance, desert plant communities were dominated by the shrubs with low level species richness. In burrow areas and surrounding intermediate areas, which were disturbed by great gerbils, the shrubs were suppressed with the decrease of vegetation cover and aboveground biomass. As a result, 'niche gaps' were created in disturbed areas and worked as a refuge for herbaceous annuals and perennials. So the existence of great gerbils increased the overall species richness of the desert. Furthermore, herbaceous annuals and perennials are the major food source for great gerbils in spring, indicating that great gerbils have a mutually beneficial relationship with herbaceous plants. | XU Wenxuan LIU Wei YANG Weikang WANG Muyang XU Feng David BLANK | 2015 | Journal of Arid Land2015，7，6： | 2 |
| 9 | REVIEW: Ischemia—Reperfusion Injury of the Intestine and Protective Strategies Against Injury显示文摘 | Ismail Hameed Mallick Wenxuan Yang Marc C. Winslet Alexander M. Seifalian | 2004 | Digestive Diseases and Sciences2004，，9： | 1 |
| 10 | Diet characteristics of wild sheep(Ovis ammon darwini) in the Mengluoke Mountains,Xinjiang,China显示文摘In most arid and semi-arid regions of the world, domestic livestock and native wildlife share pastures, and their competition for forage and habitat is thought to be a serious conservation issue. Moreover, unmanaged grazing by livestock can cause the population decline in wild ungulates. The diet of an animal species is a determining aspect of its ecological niche, and investigating its diet has been one of the initial steps in basic ecology study of a new species. To get an approximate understanding of the interspecific food relationships of argali(Ovis ammon darwini) between sexes, and sympatric domestic sheep and goats, we compared the diet compositions and diet-overlaps among these herbivores, i.e., male argali, female argali, domestic sheep, and domestic goats in the Mengluoke Mountains of Xinjiang, China by using micro-histological fecal analysis. Female argali, male argali, domestic sheep and domestic goat primarily consumed forbs(43.31%±4.86%), grass(36.02%±9.32%), forbs(41.01%±9.18%), and forbs(36.22%±10.61%), respectively in warm season. All these animals consumed mostly shrubs(female argali: 36.47%±7.56%; male argali: 47.28%±10.75%; domestic sheep: 40.46%±9.56%; and domestic goats: 42.88%±9.34%, respectively) in cold season. The diet-overlaps were relatively high among all species in cold season with values ranging from 0.88 to 0.94. Furthermore, Schoener's index measured between each possible pair of 4 herbivores increased from the warm season to the cold season. The results illustrate that the high degree of diet-overlap of argali and domestic livestock(sheep and goat) may pose a threat to the survival of the argali in cold season. From the viewpoint of rangeland management and conservation of the endangered argali, the numbers of domestic sheep and goats should be limited in cold season to reduce food competition. | LI Bang XU Wenxuan David A BLANK WANG Muyang YANG Weikang | 2018 | Journal of Arid Land2018，10，3： | 1 |
| 11 | Investigation on the 773K isothermal section of Ho-Ni-Si ternary phase diagram by X-ray powder diffraction and magnetic property of Ho3NiSi2 alloy显示文摘The isothermal section of the Ho-Ni-Si system at 773 K was constructed by X-ray powder diffraction(XRD)in this work.The system contains sixteen known type structure compounds TiNiSi-type HoNiSi,BaAl4-type HoNi2Si2,CeNiSi2-type HoNiSi2,U1Co3Si5-type Ho2Ni3Si5,SmNiGe3-type HoNiSi3,Ce3 Ni6Si2-type Ho3Ni6Si2,ThMn12-type HoNi10Si2,YPd2Si-type HoNi2Si,YNi5Si3-type HoNi5Si3,YNi4Si-type HoNi4Si,Gd3NiSi2-type Ho3NiSi2,YNi6Si6-type HoNi6Si6.AlB2-type Ho2NiSi3,AlB2-type Ho3Ni2Si4,AlB2-type Ho4NiSi7,Gd3Ru4Al12-type Ho8Ni31Si11,and one unknown type structure compound Ho5Ni2Si3.At the same time,one unknown structure new phase Ho37Ni3Si60 was observed.In ternary compounds,Ho2NiSi3 and Ho4NiSi7 have the solid solution phenomena;the solid solution ranges are about Ho33.3Ni18.7-9.7Si-48.0-57.0 and Ho33.Ni-8.3-2.6Si-58.3-64.1,respectively.At the same time,quasi-binary solid solutions were detected at 773 K for Ho2Ni17,HoNi5,Ho2Ni7,HoNi3,HoNi2,HoNi,HoSi.Other binary compounds of the Ho-Ni-Si system do not show any visible solubility.The magnetic property studies show that Ho3NiSi2 compound has two successive magnetic phase transitions in a low field:a spinreorientation transition at TSR=10 K and a second order ferromagnetic(FM)-paramagnetic(PM)transition at Tc=37 K. | Xiang Chen Jixin Gong Jiaojiao Luo Wenxuan Yang Xian Qing | 2020 | Journal of Rare Earths2020，38，9： | 1 |
| 12 | A coordinate transformationbased broadband flat lens via microstrip array显示文摘 | Yang Rui Tang Wenxuan Hao Yang | 2011 | IEEE Antennas and Wireless Propagation Letters2011，，10： | 1 |
| 13 | Optimization of pyrolysis technical parameters for cotton stalk based on response surface methodology 显示文摘 | Yang Ying Zheng Wenxuan | 2014 | Applied Mechanics and Materials2014，，： | 1 |
| 14 | Effect of ischemic preconditioning on hepatic microcirculation and function in a rat model of ischemia reperfusion injury显示文摘 | Rahul S. Koti Wenxuan Yang Michael R. Dashwood Brian R. Davidson Alexander M. Seifalian | 2002 | Liver Transplantation2002，，12： | 1 |
| 15 | Rhesus monkeys exhibiting spontaneous ritualistic behaviors resembling obsessive-compulsive disorder显示文摘Obsessive-compulsive disorder(OCD)is a chronic and debilitating psychiatric disorder that affects∼2%–3%of the population globally.Studying spontaneous OCD-like behaviors in non-human primates may improve our understanding of the disorder.In large rhesus monkey colonies,we found 10 monkeys spontaneously exhibiting persistent sequential motor behaviors(SMBs)in individual-specific sequences that were repetitive,time-consuming and stable over prolonged periods.Genetic analysis revealed severely damaging mutations in genes associated with OCD risk in humans.Brain imaging showed that monkeys with SMBs had larger gray matter(GM)volumes in the left caudate nucleus and lower fractional anisotropy of the corpus callosum.The GM volume of the left caudate nucleus correlated positively with the daily duration of SMBs.Notably,exposure to a stressor(human presence)significantly increased SMBs.In addition,fluoxetine,a serotonergic medication commonly used for OCD,decreased SMBs in these monkeys.These findings provide a novel foundation for developing better understanding and treatment of OCD. | Rongwei Zhai Geya Tong Zheqin Li Weichen Song Yang Hu Sha Xu Qiqi Wei Xiaocheng Zhang Yi Li Bingbing Liao Chenyu Yuan Yinqing Fan Ge Song Yinyin Ouyang Wenxuan Zhang Yaqiu Tang Minghui Jin Yuxian Zhang He Li Zhi Yang Guan Ning Lin Dan JStein Zhi-Qi Xiong Zhen Wang | 2023 | National Science Review2023，10，11： | 1 |
| 16 | Mechanisms of allicin exposure for the sludge fermentation enhancement:Focusing on the fermentation processes and microbial metabolic traits显示文摘As a frequently used product with antimicrobial activity,consumed allicin might be dis-charged and concentrated in waste-activated sludge(WAS).However,the influence of al-licin(as an exogenous pollutant)on WAS fermentation has not been clearly revealed.This study aimed to disclose the impacts of allicin on volatile fatty acid(VFA)generation dur-ing WAS fermentation.The results showed that the appropriate presence of allicin(10 mg/g TSS)significantly enhanced the VFA yield(1894 versus 575 mg COD/L in the control)with increased acetate proportion(24.3%).Further exploration found that allicin promoted WAS solubilization,hydrolysis and acidification simultaneously.Metagenomic analysis revealed that the key genes involved in extracellular hydrolysis metabolism(i.e.,CAZymes),mem-brane transport(i.e.,gtsA and ytfT),substrate metabolism(i.e.,yhdR and pfkC)and fatty acid synthesis(i.e.,accA and accD)were all highly expressed.Allicin also induced the bacteria to produce more signalling molecules and regulate cellular functions,thereby enhancing the microbial adaptive and regulatory capacity to the unfavourable environment.Moreover,the variations in fermentative microbes and their contributions to the upregulation of func-tional genes(i.e.,ytfR,gltL,INV,iolD and pflD)for VFA generation were disclosed.Overall,the simultaneous stimulation of functional microbial abundances and metabolic activities contributed to VFA production in allicin-conditioned reactors. | Feng Wang Jingyang Luo Shiyu Fang Wenxuan Huang Yunqi Zhang Le Zhang Xiaoshi Cheng Wei Du Fang Fang Jiashun Cao Yang Wu | 2022 | Journal of Environmental Sciences2022，34，5： | 1 |
| 17 | REVIEW: Ischemia—Reperfusion Injury of the Intestine and Protective Strategies Against Injury显示文摘 | Ismail Hameed Mallick Wenxuan Yang Marc C. Winslet Alexander M. Seifalian | 2004 | Digestive Diseases and Sciences2004，，9： | 1 |
| 18 | Comparison of the meat quality and fatty acid profile of muscles in finishing Xiangcun Black pigs fed varied dietary energy levels显示文摘To study the effects of dietary energy level on the meat quality of different muscles in finishing pigs,400Xiangcun Black pigs(BW=79.55±4.77 kg)were randomly assigned to 5 treatments with varied calculated digestive energy(DE)at 3,050,3,100,3,150,3,200 and 3,250 kcal/kg,respectively.Each treatment had 8replicates with 10 pigs per replicate.Meat quality,amino acid and fatty acid composition were tested in this study.No differences in average daily gain,average daily feed intake or feed-to-gain ratio(P>0.05)were observed among dietary treatments.Glycogen concentrations of longissimus dorsi(LD)muscle in DE3150was higher than those in other groups(P<0.05).The crude fat concentration of biceps femoris(BF)muscle in DE3250 tended to be higher than that in DE3150 and DE3100 groups(P<0.05).Pigs in DE3250 and DE3200 had higher fiber density and smaller cross-sectional area of BF muscle than those in DE3150(P<0.05).Pigs in DE3150 had the highest Cu concentration in LD muscle compared with those in DE3200,DE3250(P<0.05).The C16:1 proportion of LD muscle was lower(P<0.01)and C20:1 was higher(P<0.05)in DE3050 than that in the other dietary treatments.The C18:3n6 and C20:3n6 proportions of BF muscle in DE3150 were higher than those in DE 3050,DE3200 and DE3250(P<0.05).For LD muscle,m RNA expressions of type I and IIa MyHC in group DE3150 were higher than other treatments(P<0.01).The LD muscle in DE3150 expressed higher PPARd than in other groups(P<0.01).Pigs in DE3100 expressed higher FOX1 than in DE3200 and DE3250(P<0.05).Sterol-regulatory element binding proteins(SREBPa)mRNA expression decreased linearly when dietary energy level increased in BF muscle(P<0.01).In conclusion,a200 kcal/kg decrease in digestible energy for 4 consecutive weeks did not affect growth performance of Xiangcun Black pigs.Furthermore,LD and BF muscle respond differently to dietary energy level,and meat quality was improved by the medium energy level during the finishing phase. | Can Yang Wenlong Wang Xiaowu Tang Ruilin Huang Fengna Li Wenxuan Su Yulong Yin Chaoyue Wen Jian Liu | 2022 | Animal Nutrition2022，，4： | 1 |
| 19 | REVIEW: Ischemia—Reperfusion Injury of the Intestine and Protective Strategies Against Injury显示文摘 | Ismail Hameed Mallick Wenxuan Yang Marc C. Winslet Alexander M. Seifalian | 2004 | Digestive Diseases and Sciences2004，，9： | 1 |
| 20 | An ischemic area-targeting,peroxynitrite-responsive,biomimetic carbon monoxide nanogenerator for preventing myocardial ischemia-reperfusion injury显示文摘Myocardial ischemia-reperfusion (MI/R) injury is common in patients who undergo revascularization therapy for myocardial infarction, often leading to cardiac dysfunction. Carbon monoxide (CO) has emerged as a therapeutic molecule due to its beneficial properties such as anti-inflammatory, anti-apoptotic, and mitochondrial biogenesis-promoting properties. However, its clinical application is limited due to uncontrolled release, potential toxicity, and poor targeting efficiency. To address these limitations, a peroxynitrite (ONOO )-triggered CO donor (PCOD585) is utilized to generate a poly (lactic-co-glycolic acid) (PLGA)-based, biomimetic CO nanogenerator (M/PCOD@PLGA) that is coated with the macrophage membrane, which could target to the ischemic area and neutralize proinflammatory cytokines. In the ischemic area, local produced ONOO triggers the continuous release of CO from M/PCOD@PLGA, which efficiently ameliorates MI/R injury by clearing harmful ONOO , attenuating the inflammatory response, inhibiting cardiomyocyte apoptosis, and promoting mitochondrial biogenesis. This study provides a novel insight into the safe therapeutic use of CO for MI/R injury by utilizing a novel CO donor combined with biomimetic technology. The M/PCOD@PLGA nanogenerator offers targeted delivery of CO to the ischemic area, minimizing potential toxicity and enhancing therapeutic efficacy. | Jinyan Zhang Liwei Liu Zhen Dong Xicun Lu Wenxuan Hong Jin Liu Xiaoyi Zou Jinfeng Gao Hao Jiang Xiaolei Sun Kai Hu Youjun Yang Junbo Ge Xiao Luo Aijun Sun | 2023 | Bioactive Materials2023，，10： | 1 |
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