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| 1 | Degradation and detoxification of microcystin-LR in drinking water by sequential use of UV and ozone显示文摘Microcystins (MCs) produced by cyanobacteria are strong hepatotoxins and classified as possible carcinogens.MCs pose a considerable threat to human health through tainted drinking and surface waters.Herein filtrated water from a waterworks in Harbin,China,was spiked with microcystin-LR (MC-LR) extracted from a toxic scum of microcystis aeruginosa,and the spiked sample waters were treated using UV irradiation with consequent ozonation process (UV/O3),compared with ozonation at a dose range commonly applied in water treatment plants,UV irradiation at 254 nm and UV irradiation combined with ozonation (UV+O3),respectively.The remaining of toxins were analyzed using high-performance liquid chromatography and also determined using a protein phosphatase type 2A inhibition assay,which was utilized to evaluate the reduction in toxicity.Results indicated that in comparison to other three processes (O3,UV,and UV+O3),UV/O 3 process could effectively decrease both the concentration and toxicity of MC-LR at 100 μg/L level after 5 min UV irradiation with consequent 5 min ozonation at 0.2 mg/L (below 1 μg/L),while 0.5 mg/L ozone dose was required for the level below 0.1 μg/L.The addition of an UV treatment step to the existing treatment train may induce significant transformation of micropollutants and breaks down the natural organic matters into moieties unfavorable for ozone decomposition,stabilizing the ozone residual.These findings suggested that sequential use of UV and ozone may be a suitable method for the removal of these potentially hazardous microcystins from drinking water. | Xiaowei Liu Zhonglin Chen Nan Zhou Jimin Shen Miaomiao Ye | 2010 | Journal of Environmental Sciences2010，22，12： | 11 |
| 2 | First dark matter search results from the PandaX-Ⅰ experiment显示文摘We report on the first dark-matter(DM)search results from PandaX-I,a low threshold dual-phase xenon experiment operating at the China JinPing Underground Laboratory.In the 37-kg liquid xenon target with 17.4 live-days of exposure,no DM particle candidate event was found.This result sets a stringent limit for low-mass DM particles and disfavors the interpretation of previously-reported positive experimental results.The minimum upper limit,3.7×10-44cm2,for the spin-independent isoscalar DM-particle-nucleon scattering cross section is obtained at a DM-particle mass of 49 GeV/c2at 90%confidence level. | XIAO MengJiao XIAO Xiang ZHAO Li CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HU Jie HUANG XingTao JI XiangDong JU YongLin LEI SiAo LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing STEPHENSON Scott TAN AnDi TARL Greg WANG HongWei WANG JiMin WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIE PengWei YOU YingHui ZENG XiongHui ZHANG Hua ZHANG Tao ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，11： | 10 |
| 3 | Who is Going to Supply the Milk to China's South?显示文摘中国的奶店工业在最近的年里经历了快速的扩大,与从 2000 ~ 2006 的 23.8% 的平均年度生长率。然而,在那里存在在牛奶生产和消费的严肃的地理分发不平衡。约 85% 中国的牛奶在北中国被生产,在 40% 这个国家的人口住的地方。相反,仅仅大约 15% 牛奶在中国的南方被生产,在 60% 中国的人口住的地方。这在南部的中国导致了在牛奶生产和消费之间的重要差距,这差距被期望升起。这篇论文考虑中国的牛奶需求和供应状况,分析可能的潜力让中国扩展它的牛奶生产并且探索为遇见牛奶需求的选择—供应缺乏。政策和贸易含意被讨论。 | Jimin Wang Zhangyue Zhou Qiuhong Shen | 2008 | China & World Economy2008，16，4： | 3 |
| 4 | First results on ^(76)Ge neutrinoless double beta decay from CDEX-1 experiment显示文摘We report the first results on ^(76)Ge neutrinoless double beta decay from stage one of the China dark-matter experiment(CDEX).A p-type point-contact high-purity germanium detector with a mass of 994 g has been installed to detect neutrinoless double beta decay events, as well as to directly detect dark matter particles. An exposure of 304 kg d has been analyzed over a wide spectral band from 500 keV to 3 MeV. The average event rate obtained was about 0.012 counts per keV per kg per day over the 2.039 MeV energy range. The half-life of ^(76)Ge neutrinoless double beta decay derived based on this result is T^(0ν)1/2>6.4×10^(22) yr(90% C.L.). An upper limit on the effective Majorana-neutrino mass of 5.0 eV has been achieved. | Li Wang Qian Yue KeJun Kang JianPing Cheng YuanJing Li TszKing Henry Wong ShinTed Lin JianPing Chang JingHan Chen QingHao Chen YunHua Chen Zhi Deng Qiang Du Hui Gong Li He QingJu He JinWei Hu HanXiong Huang TengRui Huang LiPing Jia Hao Jiang HauBin Li Hong Li JianMin Li Jin Li Jun Li Xia Li XueQian Li YuLan Li FongKay Lin ShuKui Liu Hao Ma JingLu Ma XingYu Pan Jie Ren XiChao Ruan ManBin Shen Vivek Sharma Lakhwinder Singh Manoj Kumar Singh Manoj Kumar Singh Arun Kumar Soma ChangJian Tang WeiYou Tang ChaoHsiung Tseng JiMin Wang Qing Wang ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue LiTao Yang SongWei Yang Nan Yi ChunXu Yu HaiJun Yu WeiHe Zeng XiongHui Zeng Zhi Zeng Lan Zhang YunHua Zhang MingGang Zhao Wei Zhao JiFang Zhou ZuYing Zhou JingJun Zhu WeiBin Zhu ZhongHua Zhu | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，7： | 3 |
| 5 | Pathological matrix stiffness promotes cardiac fibroblast differentiation through the POU2F1 signaling pathway显示文摘Cardiac fibroblast(CF)differentiation into myofibroblasts is a crucial cause of cardiac fibrosis,which increases in the extracellular matrix(ECM)stiffness.The increased stiffness further promotes CF differentiation and fibrosis.However,the molecular mechanism is still unclear.We used bioinformatics analysis to find new candidates that regulate the genes involved in stiffnessinduced CF differentiation,and found that there were binding sites for the POU-domain transcription factor,POU2F1(also known as Oct-1),in the promoters of 50 differentially expressed genes(DEGs)in CFs on the stiffer substrate.Immunofluorescent staining and Western blotting revealed that pathological stiffness upregulated POU2F1 expression and increased CF differentiation on polyacrylamide hydrogel substrates and in mouse myocardial infarction tissue.A chromatin immunoprecipitation assay showed that POU2F1 bound to the promoters of fibrosis repressors IL1R2,CD69,and TGIF2.The expression of these fibrosis repressors was inhibited on pathological substrate stiffness.Knockdown of POU2F1 upregulated these repressors and attenuated CF differentiation on pathological substrate stiffness(35 kPa).Whereas,overexpression of POU2F1 downregulated these repressors and enhanced CF differentiation.In conclusion,pathological stiffness upregulates the transcription factor POU2F1 to promote CF differentiation by inhibiting fibrosis repressors.Our work elucidated the crosstalk between CF differentiation and the ECM and provided a potential target for cardiac fibrosis treatment. | Mingzhe Li Jimin Wu Guomin Hu Yao Song Jing Shen Junzhou Xin Zijian Li Wei Liu Erdan Dong Ming Xu Youyi Zhang Han Xiao | 2021 | Science China(Life Sciences)2021，64，2： | 3 |
| 6 | Oridonin and its derivatives for cancer treatment and vercoming therapeutic resistance显示文摘Cancer is one of the diseases with high morbidity and mortality on a global scale.Chemotherapy remains the primary treatment option for most cancer patients,including patients with progressive,metastatic,and recurrent diseases.To date,hundreds of chemotherapy drugs are used to treat various cancers,however,the anti-cancer eficacy and outcomes are largely hampered by chemotherapy-associated toxicity and acquired therapeutic resistance.The natural product(NP)oridonin has been extensively studied for its anti-cancer efficacy.More recently,oridonin has been shown to overcome drug resistance through multiple mechanisms,with yet-to-be-defined bona fide targets.Hundreds of oridonin derivative analogs(oridonalogs)have been synthesized and screened for improved potency,bioavailability,and other drug properties.Particularly,many of these oridonalogs have been tested against oridonin for tumor growth inhibition,potential for overcoming therapeutic resistance,and immunity modulation.This concise review seeks to summarize the advances in this field in light of identifying clinical-trial level drug candidates with the promise for treating progressive cancers and reversing chemoresistance. | Xi Liu Jimin Xu Jia Zhou Qiang Shen | 2021 | Genes & Diseases2021，8，4： | 2 |
| 7 | Catalytic ozonation ofp-ch- loronitrobenzene over pumice-supported zinc oxyhydroxide显示文摘 | Yuan Lei Shen Jimin Chen Zhonglin | 2013 | Water Science & Technology2013，68，8： | 1 |
| 8 | Pumice-catalyzed ozona-tion degradation of p-chloronitrobenzene in aqueous solution显示文摘 | Yuan Lei Shen Jimin Chen Zhonglin | 2012 | Applied Catalysis B:Environmental2012，，： | 1 |
| 9 | Construction of versatile multilayered composite nanoparticles from a customized nanogel template显示文摘We present a highly adaptable design platform for multi-responsive,multilayered composite nanoparticles(MC-NPs)with fine-tunable functional layers.A flexible disulfide-linked nanogel template is obtained by a controlled in-situ gelation method,enabling a high degree of control over each successive layer.From this template,we optimize“smart”biomaterials with biofunctional surfaces,tunable drug release kinetics,and magnetic or pH-responsive functionality,fabricated into MC-NPs for targeted drug release and periosteum-mimetic structures for controlled rhBMP-2 release towards bone tissue formation in-vivo.Such a versatile platform for the design of MC-NPs is a powerful tool that shows considerable therapeutic potential in clinical fields such as oncology and orthopedics. | Jian Zhang Jinpeng Jia Jimin P.Kim Fei Yang Xing Wang Hong Shen Sijia Xu Jian Yang Decheng Wu | 2018 | Bioactive Materials2018，3，1： | 1 |
| 10 | Removal of phosphate from secondary effluent with Fe 2+ enhanced by H 2 O 2 at nature pH/neutral pH显示文摘 | Chunjuan Li Jun Ma Jimin Shen Peng Wang | 2008 | Journal of Hazardous Materials2008，，2： | 1 |
| 11 | Reinvestigation of thenitrosamine-formation mechanism during ozonation 显示文摘 | Yang Lei Chen zhonglin Shen jimin | 2009 | Envi Sci Tech2009，43，14： | 1 |
| 12 | Distribution of polycyclic aromatic hydrocarbons insurface water and sediment near a drinking waterreservoir in Northeastern China 显示文摘 | LIU Yu SHEN Jimin CHEN Zhonglin | 2013 | EnvironmentalScience and Pollution Research2013，20，4： | 1 |
| 13 | Effects of amorphous-zinc- silicate-catalyzed ozonation on the degradation of p-chloronitroben- zene in drinking water 显示文摘 | Liu Yue Shen Jimin Chen Zhonglin | 2011 | Applied Catalysis A :General2011，403，12： | 1 |
| 14 | Degradation of p-chlomi- trobenzene in drinking water by manganese silicate catalyzed ozona- tion 显示文摘 | Liu Yue Shen Jimin Chen Zhonglin | 2011 | Desalination2011，279，123： | 1 |
| 15 | Reinvestigation of the nitrosamine-formation mechanism during ozonation显示文摘 | YANG Lei CHEN zhonglin SHEN jimin | 2009 | Envi Sci Tech2009，43，14： | 1 |
| 16 | Vanadium carbide and graphite promoted Pd electrocatalyst for ethanol oxidation in alkaline media显示文摘 | Zaoxue Yan Mingmei Zhang Jimin Xie Pei Kang Shen | 2013 | Journal of Power Sources2013，，： | 1 |
| 17 | Kinetics and mechanism of degradation of p-chloronitrobenzene in water by ozonation 显示文摘 | SHEN Jimin CHEN Zhonglin XU Zhenzhen | 2008 | Journai of Hazardous Materials2008，152，3： | 1 |
| 18 | Ozone enhanced activity of aqueous titanium dioxide suspensions for photodegradation of 4-chloronitrobenzene显示文摘 | Miaomiao Ye Zhonglin Chen Xiaowei Liu Yue Ben Jimin Shen | 2009 | Journal of Hazardous Materials2009，，1： | 1 |
| 19 | Synthesized heterogeneous Fenton-like goethite (FeOOH) catalyst for degradation ofp-chloro- nitrobenzene 显示文摘 | Shen Jimin Zhu Jiayi Kong Yanli | 2013 | Water Science & Technology2013，68，7： | 1 |
| 20 | Effects of amorphous- zinc-silicate-catalyzed ozonation on the degradation of p-chloroni- trobenzene in drinking water 显示文摘 | Liu Yue Shen Jimin Chen Zhonglin | 2011 | Applied Catalysis A :General2011，403，112： | 1 |
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