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| 1 | Changes of activated circulating endothelial cells and survivin in patients with non-small cell lung cancer after antiangiogenesis therapy显示文摘背景尽管 antiangiogenesis 治疗与它的公认的功效和细微不利效果在反肿瘤的治疗起一个重要作用,没有未来的临床的试用为预言 antiangiogenic therapy.This 学习的功效被承担在预言非小的 cel 的 therapy.Methods 病人的功效在 anti-angiogenesis 治疗和他们的意义以后调查激活的传播 endothelial 房间( aCECs )和 survMn | WANG Jing HUANG Chun WEI Xi-yin QI Da-liang GONG Li-qun MU Hai-yu YAO Qiang LI Kai | 2008 | Chinese Medical Journal2008，，22： | 24 |
| 2 | 经尿道等离子体前列腺电切术是一种治疗良性前列腺增生可靠的微创术式:一项随机对照试验的荟萃分析显示文摘我们进行一项随机对照试验的荟萃分析来评估经尿道等离子体电切术(PKRP)和经尿道前列腺电切术(TURP)治疗良性前列腺增生的疗效性和安全性。我们检索了PubMed,Embase,WebofScience和CochraneLibrary。对最大尿流率、国际前列腺症状评分、手术时间、留置导尿时间、冲洗量、住院时间和经尿道前列腺电切综合征、输血、血块凝结、尿潴留和尿道狭窄的风险率进行评估。TURP和PKRP两组在随访的1、3、6和12月的国际前列腺症状评分上无明显差异,而PKRP组1月后的Qmax优于TURP组。PKRP组的经尿道前列腺电切综合症、输血和血块凝结的风险率更低,且留置导尿时间和手术时间都短于TURP组。而冲洗量、住院时间,尿潴留和尿道狭窄发生率无显著差异。总之,我们的研究表明PKRP是可靠的且能够成为治疗BPH的一种微创术式。 | Kai Wang Yao Li Jing-Fei Teng Hai-Yong Zhou Dan-Feng Xu Yi Fan | 2015 | Asian Journal of Andrology2015，17，1： | 19 |
| 3 | Immunogenicity noninferiority study of 2 doses and 3 doses of an Escherichia coli-produced HPV bivalent vaccine in girls vs.3 doses in young women显示文摘A new HPV-16/18 bivalent vaccine expressed by the Escherichia coli has been proven to be efficacious in adult women.A randomized,immunogenicity noninferiority study of this candidate vaccine was conducted in December 2015 in China.Girls aged 9–14 years were randomized to receive 2 doses at months 0 and 6(n=301)or 3 doses at months 0,1 and 6(n=304).Girls aged 15–17 years(n=149)and women aged 18–26 years(n=225)received 3 doses.The objectives included noninferiority analysis of the IgG geometric mean concentration(GMC)ratio(95%CI,lower bound>0.5)to HPV-16 and HPV-18 at month 7 in girls compared with women.In the per-protocol set,the GMC ratio of IgG was noninferior for girls aged 9–17 years receiving 3 doses compared with women(1.76(95%CI,1.56,1.99)for HPV-16 and 1.93(95%CI,1.69,2.21)for HPV-18)and noninferior for girls aged 9–14 years receiving 2 doses compared with women(1.45(95%CI,1.25,1.62)for HPV-16 and 1.17(95%CI,1.02,1.33)for HPV-18).Noninferiority was also demonstrated for neutralizing antibodies.The immunogenicity of the HPV vaccine in girls receiving 3 or 2 doses was noninferior compared with that in young adult women. | Yue-Mei Hu Meng Guo Chang-Gui Li Kai Chu Wen-Gang He Jing Zhang Jian-Xiang Gu Juan Li Hui Zhao Xiang-Hong Wu Bi-Zhen Lin Zhi-Jie Lin Xing-Mei Yao Ya-Fei Li Fei-Xue Wei Yue Huang Ying-Ying Su Feng-Cai Zhu Shou-Jie Huang Hui-Rong Pan Ting Wu Jun Zhang Ning-Shao Xia | 2020 | Science China(Life Sciences)2020，63，4： | 19 |
| 4 | Human monoclonal antibodies block the binding of SARS-CoV-2 spike protein to angiotensin converting enzyme 2 receptor显示文摘According to the World Health Organization(WHO)newly updated situation report on March 18th,2020,the coronavirus disease 2019(COVID-19)pandemic has confirmed 191,127 cases and claimed 7807 deaths worldwide.1 The etiological agent of COVID-19 has been identified as a novel coronavirus,the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),belonging to Sarbecovirus subgenus(genus Betacoronavirus,family Coronaviridae)and showing 79.6 and 96.2%sequence identity in nucleotide to SARS-CoV and a bat coronavirus(BatCoV RaTG13),respectively.2–4 Like SARS-CoV infection,a substantial fraction of COVID-19 patients exhibits severe respiratory symptoms and has to be hospitalized in intensive care unit.5–8 Although the mortality rate of COVID-19 is significantly lower than that of SARS-CoV infection,SARS-CoV-2 shows much higher human-to-human transmission rate,rapidly leading to a global pandemic declared by WHO on March 11th,2020. | Xiangyu Chen Ren Li Zhiwei Pan Chunfang Qian Yang Yang Renrong You Jing Zhao Pinghuang Liu Leiqiong Gao Zhirong Li Qizhao Huang Lifan Xu Jianfang Tang Qin Tian Wei Yao Li Hu Xiaofeng Yan Xinyuan Zhou Yuzhang Wu Kai Deng Zheng Zhang Zhaohui Qian Yaokai Chen Lilin Ye | 2020 | Cellular & Molecular Immunology2020，17，6： | 17 |
| 5 | Adipose-derived mesenchymal stem cell transplantation promotes adult neurogenesis in the brains of Alzheimer's disease mice显示文摘In the present study,we transplanted adipose-derived mesenchymal stem cells into the hippocampi of APP/PS1 transgenic Alzheimer’s disease model mice.Immunofluorescence staining revealed that the number of newly generated(BrdU+)cells in the subgranular zone of the dentate gyrus in the hippocampus was significantly higher in Alzheimer’s disease mice after adipose-derived mesenchymal stem cell transplantation,and there was also a significant increase in the number of BrdU+/DCX+neuroblasts in these animals.Adipose-derived mesenchymal stem cell transplantation enhanced neurogenic activity in the subventricular zone as well.Furthermore,adipose-derived mesenchymal stem cell transplantation reduced oxidative stress and alleviated cognitive impairment in the mice.Based on these findings,we propose that adipose-derived mesenchymal stem cell transplantation enhances endogenous neurogenesis in both the subgranular and subventricular zones in APP/PS1 transgenic Alzheimer’s disease mice,thereby facilitating functional recovery. | Yufang Yan Tuo Ma Kai Gong Qiang Ao Xiufang Zhang Yao Gong | 2014 | Neural Regeneration Research2014，9，8： | 16 |
| 6 | Eleven COVID-19 Outbreaks with Local Transmissions Caused by the Imported SARS-CoV-2 Delta VOC-China,July-August,2021显示文摘Starting from December 2019,Wuhan,China,encountered the first outbreak of coronavirus disease 2019(COVID-19)(1-2).The epidemic was successfully suppressed by strict containment so that the number of infected people was reduced to 0 on April 8,2020(3–4).After that,China experienced roughly 3 dozen outbreaks with local transmission caused by imported severe acute respiratory syndrome coronavirus 2(SARS-CoV-2). | Lei Zhou Kai Nie Hongting Zhao Xiang Zhao Bixiong Ye Ji Wang Cao Chen Hong Wang Jiangli Di Jinsong Li Chao Li Zhixiao Chen Ruiqi Ren Peihua Niu Hui Chen Tao Chen Yali Wang Lili Li Bingxue Han Ruhan A Si Chen Dan Li Dan Li Chunxia Jin Xin Zhang Jiangmei Liu Chunyu Xu Yecheng Yao Yenan Feng Zhili Li Bike Zhang Yang Song Peter Hao Yanping Zhang Hao Li Qun Li George F.Gao Guoqing Shi Wenbo Xu | 2021 | China CDC weekly2021，3，41： | 13 |
| 7 | Survey for late-onset hypogonadism among old anti middle-aged males in Shanghai communities显示文摘这研究寻求了在上海社区在老、中年的男性调查迟了发作的性腺机能减退(LOH ) ,用症状 20 评估系统和性别荷尔蒙层次的大小。40-70 年的男性的 1000 个案例被调查。在使男性( ADAM )变老的变老的男症状( AMS )规模和雄激素缺乏问询表在调查的开始被使用,由性别的测量列在后面荷尔蒙相关的因素(全部的睾丸激素( TT ),免费睾丸激素(英尺),性别荷尔蒙绑定血球素( SHBG )和睾丸激素( Bio-T )的 bioavailability )。有 977 张有效问询表。AMS 和 ADAM 显示出的 LOH 积极的率是 59.88 %并且 84.65 %分别地;价值与病人的年龄增加了。与性别荷尔蒙大小有关有 946 结果,它显示出下列结果:TT 不与老化有关(P> 0.05 ) ;SHBG 的层次与年龄增加了;并且英尺和 Bio-T 与年龄减少了。在在 LOH 积极、 LOH 否定的病人之间的英尺有重要差别,作为由 ADAM 出现。在摘要,当英尺和 Bio-T 与老化减少了时, TT 层次不与老化有关,尽管 SHBG 确实增加了。临床上, LOH 的诊断不能基于浆液 TT 水平。 | Kai Sun GuoTQing Liang Xiang-Feng Chen Ping Ping Wen-Liang Yao Shi-Jun Zhang Bo Wang Ying-Hao Sun Zheng Li | 2012 | Asian Journal of Andrology2012，14，2： | 13 |
| 8 | Late-Quaternary Slip Rate and Seismic Activity of the Xianshuihe Fault Zone in Southwest China显示文摘The Xianshuihe fault zone is a seismo-genetic fault zone of left-lateral slip in Southwest China. Since 1725, a total of 59 Ms ≥ 5.0 earthquakes have occurred along this fault zone, including 18 Ms 6.0–6.9 and eight Ms ≥ 7.0 earthquakes. The seismic risk of the Xianshuihe fault zone is a large and realistic threat to the western Sichuan economic corridor. Based on previous studies, we carried out field geological survey and remote sensing interpretation in the fault zone. In addition, geophysical surveys, trenching and age-dating were conducted in the key parts to better understand the geometry, spatial distribution and activity of the fault zone. We infer to divide the fault zone into two parts: the northwest part and the southeast part, with total eight segments. Their Late Quaternary slip rates vary in a range of 11.5 mm/a –(3±1) mm/a. The seismic activities of the Xianshuihe fault zone are frequent and strong, periodical, and reoccurred. Combining the spatial and temporal distribution of the historical earthquakes, the seismic hazard of the Xianshuihe fault zone has been predicted by using the relationship between magnitude and frequency of earthquakes caused by different fault segments. The prediction results show that the segment between Daofu and Qianning has a possibility of Ms ≥ 7.0 earthquakes, while the segment between Shimian and Luding is likely to have earthquakes of about Ms 7.0. It is suggested to establish a GPS or In SAR-based real-time monitoring network of surface displacement to cover the Xianshuihe fault zone, and an early warning system of earthquakes and post seismic geohazards to cover the major residential areas. | ZHANG Yongshuang YAO Xin YU Kai DU Guoliang GUO Changbao | 2016 | Acta Geologica Sinica(English Edition)2016，90，2： | 12 |
| 9 | Theoretical research on reservoir closed-loop production management显示文摘Closed-loop production management combines the process of history matching and production optimization together to peri-odically updates the reservoir model and determine the optimal control strategy for production development to realize the goal of decreasing the knowledge of model uncertainty as well as maximize the economic benefits for the expected reservoir life. The adjoint-gradient-based methods seem to be the most efficient algorithms for closed-loop management. Due to complicated calculation and limited availability of adjoint-gradient in commercial reservoir simulators, the application of this method is still prohibited for real fields. In this paper, a simultaneous perturbation stochastic approximation (SPSA) algorithm is proposed for reservoir closed-loop production management with the combination of a parameterization way for history matching and a co-variance matrix to smooth well controls for production optimization. By using a set of unconditional realizations, the proposed parameterization method can transform the minimization of the objective function in history matching from a higher dimension to a lower dimension, which is quite useful for large scale history matching problem. Then the SPSA algorithm minimizes the objective function iteratively to get an optimal estimate reservoir model. Based on a prior covariance matrix for production op-timization, the SPSA algorithm generates a smooth stochastic search direction which is always uphill and has a certain time correlation for well controls. The example application shows that the SPSA algorithm for closed-loop production management can decrease the geological uncertainty and provide a reasonable estimate reservoir model without the calculation of the ad-joint-gradient. Meanwhile, the well controls optimized by the alternative SPSA algorithm are fairly smooth and significantly improve the effect of waterflooding with a higher NPV and a better sweep efficiency than the reactive control strategy. | ZHAO Hui LI Yang YAO Jun ZHANG Kai | 2011 | Science China(Technological Sciences)2011，54，10： | 11 |
| 10 | Relationship Between Measured Friction Coefficients and Two Tread Groove Design Parameters for Footwear Pads显示文摘The shoe sole geometrical design parameters are believed to be important factors affecting the coefficient of friction (COF) between the shoe/floor interface. This study is concerned with the relationship between the measured COF and the tread groove orientation and width on the footwear pad. Friction meas-urements using the Brungraber Mark Ⅱ slipmeter were conducted. Six tread groove width/orientations de-signs on the footwear pads under 27 footwear material/floor/contamination conditions were tested. The re-sults show that tread orientation and width affect the measured COF significantly. Wider grooved footwear pads result in higher COF values and footwear pads with tread grooves perpendicular to the friction meas-urement direction have higher COF values. A regression model using measured COF as the dependent variable and tread groove width, groove orientation, footwear material, floor, and contamination conditions as independent variables was established. The models are significant at p<0.0001 with R2 of 0.97, which may be used in predicting the COF at the shoe-floor interface. | LI Kai Way CHEN Chin Jung LIN Ching-Hua HSU Yao Wen | 2006 | Tsinghua Science and Technology2006，11，6： | 11 |
| 11 | Method of oxygen-enriched two-stage underground coal gasification显示文摘二阶段的地下的煤气化被学习改进 syngas 的热量的价值并且扩大煤气的生产时间。用充实氧的二阶段的煤气化方法的模型测试被执行。生产的气体的作文,二个阶段的时间比率,和温度地的角色被分析。充实氧的二阶段的气化弄短的结果表演第一个阶段的时间并且延长第二个阶段的时间。喂 30% , 35% , 40% , 45% , 60% ,或 80% 的集中分别地给了 1:0.12, 1:0.21, 1:0.51, 1:0.64, 1:0.90,和 1:4.0 的时间比率(第二上演的第一个阶段) 的氧。在蒸气注射以后的温度领域的冷却的率从大约 19.127.4 与时间减少了吗?? | Liu Hongtao Chen Feng Pan Xia Yao Kai Liu Shuqin | 2011 | Mining Science and Technology2011，21，2： | 11 |
| 12 | Microbial aerosol characteristics in highly polluted and nearpristine environments featuring different climatic conditions显示文摘There is an increasing interest in understanding ambient bioaerosols due to their roles both in health and in climate. Here, we deployed an Ultraviolet Aerodynamic Particle Sizer to monitor viable(fluorescent) bioaerosol concentration levels at city centers(highly polluted) and their corresponding suburbs(near pristine)(total 40 locations) in 11 provinces featuring different climate zones in China between July 16 and 28, 2013. The concentration levels of viable bioaerosol particles(Bio PM) of [0.5 lm were measured, and corresponding percentages of Bio PM%(biological fraction of total PM) and Bio PM2.5%(biological fraction of PM2.5) in particulate matter(PM)and Bio PM, respectively, were determined. For some key cities, indoor viable bioaerosol levels were also obtained.In addition, bacterial structures of the air samples collected across these monitoring locations were studied using pyrosequencing. Bio PM concentration levels ranged from2.1 9 104 to 2.4 9 105/m3 for city centers [Bio PM% =6.4 %(±6.3 %)] and 0.5 9 104 to 4.7 9 105/m3 for suburbs [Bio PM% = 10 %(±8.7 %)]. Distinctive bioaerosol size distribution patterns were observed for different climate zones, e.g., some had fluorescence peaks at 3 lm, while the majority had peaks at 1 lm. Ambient bacterial aerosol community structures were also found different for different geophysical locations. Results suggest that there was a poor overall relationship between PM and Bio PM across 40 monitoring locations(R2= 0.081, two-tailed P value =0.07435). Generally, city centers had higher PM concentrations than suburbs, but not Bio PM and Bio PM%. Indoor bioaerosol levels were found at least tenfold higher than those corresponding outdoors. Bacillus was observed to dominate the bacterial aerosol community in the air sample. | Kai Wei Yunhao Zheng Jing Li Fangxia Shen Zhuanglei Zou Hanqing Fan Xinyue Li Chang-yu Wu Maosheng Yao | 2015 | Science Bulletin2015，60，16： | 10 |
| 13 | Apatinib, a selective VEGFR2 inhibitor, improves the delivery of chemotherapeutic agents to tumors by normalizing tumor vessels in LoVo colon cancer xenograft mice显示文摘Tumor vascular normalization has been proposed as a therapeutic strategy for malignant neoplasms, which can also interpret the synergistic effect of anti-angiogenesis agents combined with chemotherapy. Apatinib (Apa), a highly selective VEGFR2 inhibitor, attracts much attentions due to its encouraging anticancer activity, especially in the clinical trials of combined treatment. In this study, we investigated whether Apa could promote vascular normalization in tumor in a certain time window. Mice bearing LoVo colon cancer xenograft were orally administrated Apa (150 mg kg^-1 per day) for 5, 7, 10, or 12 days. Apa significantly inhibited tumor growth and decreased the microvessel density. Using multi-photon microscopy and electron microscopy, we found that Apa improved tumor vessel morphology by pruning distorted vessel branches and decreased the gap between endothelial cells after a 7-day treatment. Furthermore, Apa decreased vessel leakage and in creased pericyte coverage on vascular en dothelial cells, suggesting that tumor vessels were more mature and integrated. The intratumoral distribution of adriamycin (ADR) in Apa group was improved from day 7 to 10 without change in plasma drug concen tration. Tumor blood perfusion was also in creased in this window, and the expression of hypoxia induced factor 1a was downregulated, suggesting the effect of Apa on alleviating tumor hypoxic micro-e nvironme nt. In conclusi on, Apa may improve the effective perfusi on of tumor vessels and in crease the intratumoral distribution of ADR in a certain time window via normalizing tumor vessels. This normalization window (7 to 10 days of treatment) may con tribute to develop a regime n of combi ned medication in clinic use of Apa. | Kai Zhou Jing-wei Zhang Qi-zhi Wang Wen-yue Liu Jia-li Liu Lan Yao Ming-min Cai Sui-ying Ni Qing-yun Cai Guang-ji Wang Fang Zhou | 2019 | Acta Pharmacologica Sinica2019，40，4： | 10 |
| 14 | Optically pumped terahertz sources显示文摘High-power terahertz(THz) generation in the frequency range of 0.1-10 THz has been a fast-developing research area ever since the beginning of the THz boom two decades ago, enabling new technological breakthroughs in spectroscopy, communication, imaging,etc. By using optical(laser) pumping methods with near-or mid-infrared(IR) lasers, flexible and practical THz sources covering the whole THz range can be realized to overcome the shortage of electronic THz sources and now they are playing important roles in THz science and technology. This paper overviews various optically pumped THz sources, including femtosecond laser based ultrafast broadband THz generation, monochromatic widely tunable THz generation, single-mode on-chip THz source from photomixing, and the traditional powerful THz gas lasers. Full descriptions from basic principles to the latest progress are presented and their advantages and disadvantages are discussed as well. It is expected that this review gives a comprehensive reference to researchers in this area and additionally helps newcomers to quickly gain understanding of optically pumped THz sources. | ZHONG Kai SHI Wei XU DeGang LIU PengXiang WANG YuYe MEI JiaLin YAN Chao FU ShiJie YAO JianQuan | 2017 | Science China(Technological Sciences)2017，60，12： | 9 |
| 15 | The gut microbial metabolite, 3,4-dihydroxyphenylpropionic acid, alleviates hepatic ischemia/reperfusion injury via mitigation of macrophage pro-inflammatory activity in mice显示文摘Hepatic ischemia/reperfusion injury(HIRI) is a serious complication that occurs following shock and/or liver surgery. Gut microbiota and their metabolites are key upstream modulators of development of liver injury. Herein, we investigated the potential contribution of gut microbes to HIRI.Ischemia/reperfusion surgery was performed to establish a murine model of HIRI. 16 S r RNA gene sequencing and metabolomics were used for microbial analysis. Transcriptomics and proteomics analysis were employed to study the host cell responses. Our results establish HIRI was significantly increased when surgery occurred in the evening(ZT12, 20:00) when compared with the morning(ZT0, 08:00);however, antibiotic pretreatment reduced this diurnal variation. The abundance of a microbial metabolite3,4-dihydroxyphenylpropionic acid was significantly higher in ZT0 when compared with ZT12 in the gut and this compound significantly protected mice against HIRI. Furthermore, 3,4-dihydroxyphenylpropionic acid suppressed the macrophage pro-inflammatory response in vivo and in vitro. This metabolite inhibits histone deacetylase activity by reducing its phosphorylation. Histone deacetylase inhibition suppressed macrophage pro-inflammatory activation and diminished the diurnal variation of HIRI. Our findings revealed a novel protective microbial metabolite against HIRI in mice. The potential underlying mechanism was at least in part, via 3,4-dihydroxyphenylpropionic acid-dependent immune regulation and histone deacetylase(HDAC) inhibition in macrophages. | Rui Li Li Xie Lei Li Xiaojiao Chen Tong Yao Yuanxin Tian Qingping Li Kai Wang Chenyang Huang Cui Li Yifan Li Hongwei Zhou Neil Kaplowitz Yong Jiang Peng Chen | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 8 |
| 16 | Growth differentiation factor-15 combined with N-terminal prohormone of brain natriuretic peptide increase 1-year prognosis prediction value for patients with acute heart failure: a prospective cohort study显示文摘Background:Clinical assessment and treatment guidance for heart failure depends on a variety of biomarkers.The objective of this study was to investigate the prognostic predictive value of growth differentiation factor-15(GDF-15)and N-terminal prohormone of brain natriuretic peptide(NT-proBNP)in assessing hospitalized patients with acute heart failure(AHF).Methods:In total,260 patients who were admitted for AHF in the First Affiliated Hospital of Nanjing Medical University were enrolled from April 2012 to May 2016.Medical history and blood samples were collected within 24 h after the admission.The primary endpoint was the all-cause mortality within 1 year.The patients were divided into survival group and death group based on the endpoint.With established mortality risk factors and serum GDF-15 level,receiver-operator characteristic(ROC)analyses were performed.Cox regression analyses were used to further analyze the combination values of NT-proBNP and GDF-15.Results:Baseline GDF-15 and NT-proBNP were significantly higher amongst deceased than those in survivors(P<0.001).In ROC analyses,area under curve(AUC)for GDF-15 to predict 1-year mortality was 0.707(95%confidence interval[CI]:0.648–0.762,P<0.001),and for NT-proBNP was 0.682(95%CI:0.622–0.738,P<0.001).No statistically significant difference was found between the two markers(P=0.650).Based on the optimal cut-offs(GDF-15:4526.0 ng/L;NT-proBNP:1978.0 ng/L),the combination of GDF-15 and NT-proBNP increased AUC for 1-year mortality prediction(AUC=0.743,95%CI:0.685–0.795,P<0.001).Conclusions:GDF-15,as a prognostic marker in patients with AHF,is not inferior to NT-proBNP.Combining the two markers could provide an early recognition of high-risk patients and improve the prediction values of AHF long-term prognosis.Clinical trial registration:ChiCTR-ONC-12001944,http://www.chictr.org.cn. | Ji Hao Iokfai Cheang Li Zhang Kai Wang Hui-Min Wang Qian-Yun Wu Yan-Li Zhou Fang Zhou Dong-Jie Xu Hai-Feng Zhang Wen-Ming Yao Xin-Li Li | 2019 | Chinese Medical Journal2019，，19： | 8 |
| 17 | Pedicle Subtraction Osteotomy with a Cage Prevents Sagittal Translation in the Correction of Kyphosis in Ankylosing Spondylitis显示文摘 | Fan-Qi Hu Wen-Hao Hu Hao Zhang Kai Song Yao Wang Tian-Hao Wang Yan Wang Xue-Song Zhang | 2018 | Chinese Medical Journal2018，，2： | 8 |
| 18 | Rock-soil slope stability analysis by two-phase random media and finite elements显示文摘To investigate the strong random nature of the geometric interfaces between soil and rock, a rock-soil slope is considered as a two-phase random medium. A nonlinear translation of a Gaussian field is utilized to simulate the two-phase random media, such that the soil(or rock) volume fraction and the inclination of the soil layer can be examined. The finite element method with random media incorporated as the material properties is used to determine the factor of safety of the rock-soil slope. Monte-Carlo simulations are used to estimate the statistical characteristics of the factor of safety. The failure mode of the rock-soil slope is examined by observing the maximum principal plastic strain at incipient slope failure. It is found that the critical surface of a rock-soil slope is fairly irregular, and it significantly differs from that of a pure soil slope. The factor of safety is sensitive to the soil volume faction, but it is predictable. The average factor of safety could be well predicted by the weighted harmonic average between the strength of soil and rock; the prediction model is practical and simple. Parametric studies on the inclination of the soil layer demonstrate that the most instable scenario occurs when the slope angle is consistent with the inclination of the soil layer. | Yong Liu Huawen Xiao Kai Yao Jun Hu Hong Wei | 2018 | Geoscience Frontiers2018，9，6： | 7 |
| 19 | Regulation of transcriptionally active genes via the catalytically inactive Cas9 in C. elegans and D. rerio显示文摘 | Lijiang Long Hong Guo Di Yao Kai Xiong Yongjun Li Pengpeng Liu Zuoyan Zhu Dong Liu | 2015 | Cell Research2015，25，5： | 7 |
| 20 | A novel cooperative mid-course guidance scheme for multiple intercepting missiles显示文摘In the interception engagement,if the target movement information is not accurate enough for the mid-course guidance of intercepting missiles,the interception mission may fail as a result of large handover errors.This paper proposes a novel cooperative mid-course guidance scheme for multiple missiles to intercept a target under the condition of large detection errors.Under this scheme,the launch and interception moments are staggered for different missiles.The earlier launched missiles can obtain a relatively accurate detection to the target during their terminal guidance,based on which the latter missiles are permitted to eliminate the handover error in the mid-course guidance.A significant merit of this scheme is that the available resources are fully exploited and less missiles are needed to achieve the interception mission.To this end,first,the design of cooperative handover parameters is formulated as an optimization problem.Then,an algorithm based on Monte Carlo sampling and stochastic approximation is proposed to solve this optimization problem,and the convergence of the algorithm is proved as well.Finally,simulation experiments are carried out to validate the effectiveness of the proposed cooperative scheme and algorithm. | Long WANG Yu YAO Fenghua HE Kai LIU | 2017 | Chinese Journal of Aeronautics2017，30，3： | 7 |
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