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| 1 | IPA1 functions as a downstream transcription factor repressed by D53 in strigolactone signaling in rice显示文摘Strigolactones (SL ) ,一组类胡萝卜素导出 terpenoid 内酯,是压制射击由禁止腋的芽的长出分叉的 root-to-shoot 植物激素。矮子 53 (D53 ) ,表明小径的 SL 的关键抑压者,被推测调整 SL 反应的下游的 transcriptional 网络。然而, D53 指向的下游的抄写因素还都没被报导。这里,我们报导那理想的植物体系结构 1 (IPA1 ) ,在米饭的植物体系结构的一个关键管理者,在调整 tiller 数字和导致 SL 的基因表示作为 D53 的一个直接下游的部件工作。我们证明 D53 在 vivo 并且在 vitro 与 IPA1 交往并且压制 IPA1 的 transcriptional 激活活动。我们进一步证明 IPA1 能直接绑在 D53 倡导者并且在导致 SL 的 D53 表示的反馈规定起一个关键作用。这些调查结果表明 IPA1 是可能的与 D53 行动到的长推测的抄写因素之一调停在米饭的调整 SL 的 tiller 发展。 | Xiaoguang Song Zefu Lu Hong Yu Gaoneng Shao Jinsong Xiong Xiangbing Meng Yanhui Jing Guifu Liu Guosheng Xiong Jingbo Duan Xue-Feng Yao Chun-Ming Liu Hongqing Li Yonghong Wang Jiayang Li | 2017 | Cell Research2017，27，9： | 48 |
| 2 | Correction of a genetic disease by CRISPR-Cas9-mediated gene editing in mouse spermatogonial stem cells显示文摘Spermatogonial 干细胞(SSC ) 能在移植以后生产众多的男配偶子进接受者睾丸,介绍为基因治疗和修改基因的动物的连续生产的一条珍贵途径。然而, SSC 的成功的基因操作被限制了,部分由于复杂性和当前可得到的基因编辑技术的低效率。这里,我们证明有效基因修正能用 CRISPR-Cas9 系统被介绍进 SSC。我们使用了 CRISPR-Cas9 系统变异在 SCC 的 EGFP transgene 或内长的 Crygc 基因。变异的 SSC 在移植以后经历了精子发生进不肥沃的老鼠睾丸的生精的小管。圆 spermatids 被产生并且在进成熟卵母细胞的注射以后,支持了显示相应变异的显型的异质接合的后代的生产。而且,在 Crygc 的一个引起疾病的变化(在 SSC 先存在的 Crygc −/−) 能乐意地到加入的 CRISPR-Cas9-induced nonhomologous 结束(NHEJ ) 或指导相同的修理(HDR ) 被修理,导致没有是的离开目标修正的证据带改正的基因的 SSC 线由整个染色体的定序出现。用从这些线产生的圆 spermatids 的授精在 100% 的效率与改正的显型产生了后代。我们的结果表明有效基因由 CRISPR-Cas9 系统在老鼠 SSC 编辑,并且提供在 SSC 经由基因修正治好基因疾病的原则的证明。 | Yuxuan Wu Hai Zhou Xiaoying Fan Ying Zhang Man Zhang Yinghua Wang Zhenfei Xie Meizhu Bai Qi Yin Dan Liang Wei Tang Jiaoyang Liao Chikai Zhou Wujuan Liu Ping Zhu Hongshan Guo Hong Pan Chunlian Wu Huijuan Shi Ligang Wu Fuchou Tang Jinsong Li | 2015 | Cell Research2015，25，1： | 37 |
| 3 | Single-cell RNA-seq uncovers dynamic processes and critical regulators in mouse spermatogenesis显示文摘 | Yao Chen Yuxuan Zheng Yun Gao Zhen Lin Suming Yang Tongtong Wang Qiu Wang Nannan Xie Rong Hua Mingxi Liu Jiahao Sha Michael D. Griswold Jinsong Li Fuchou Tang Ming-Han Tong | 2018 | Cell Research2018，28，9： | 26 |
| 4 | Generation of haploid embryonic stem cells from Macaca fascicularis monkey parthenotes显示文摘在从经由单性生殖和男性单性生殖的老鼠的胚胎的干细胞(haESCs ) 启用了在修改基因的动物的哺乳动物的房间和代的基因屏蔽的 haploid 的推导的最近的成功。然而, haESCs 是否能从首领被导出,仍然保持未知。这里,我们从 Macaca fascicularis 猴子的单性生殖的胚囊报导 haESCs 的推导。这些房间,作为 PG-haESCs 称为,是 pluripotent 并且能在 vitro 或在 vivo 区分到三胚胎的细菌层的房间。有趣地,一根猴子 PG-haESC 线(MPH1 ) 的 haploidy 与另一个(MPH2 ) 的相比是更稳定的,作为没有排序的激活荧光的房间(FACS ) ,由 haploid 房间的存在出现超过 140 天 haploid 房间的丰富。重要地,转基因的猴子 PG-haESC 线能被 lentivirus- 和 piggyBac 产生调停 transposon 的基因转移。而且,基因屏蔽在猴子 PG-haESCs 是可行的。我们的结果证明 PG-haESCs 能从猴子被产生,提供为在首领的基因分析的一个理想的工具。 | Hui Yang Zhen Liu Yu Ma Cuiqing Zhong Qi Yin Chikai Zhou Linyu Shi Yijun Cai Hanzhi Zhao Hui Wang Fan Tang Yan Wang Chenchen Zhang Xin-yuan Liu Dongmei Lai Ying Jin Qiang Sun Jinsong Li | 2013 | Cell Research2013，23，10： | 22 |
| 5 | One-step generation of complete gene knockout mice and monkeys by CRISPR/Cas9-mediated gene editing with multiple sgRNAs显示文摘CRISPR/Cas9 系统是一个有效编辑基因的方法,但是编辑基因的动物的多数显示出 mosaicism,与编辑仅仅在房间的部分发生。这里,我们证明那单个基因或多重基因能被 Cas9 mRNA 和多重邻近的单个指南的 RNA 的 zygotic 注射完全在老鼠和猴子胚胎击倒(spaced 10-200 bp 分开) 指向仅仅一把单个钥匙每基因的 exon。个别地在 Y 染色体上跟随八基因的指向的删除的 F0 老鼠的 Phenotypic 分析在产生猛烈老鼠表明了这条途径的坚韧性。重要地,这条途径在高效率交付完全的基因大美人(Arntl 上的 100% 并且 91% 在 Prrt2 上) 在猴子胚胎。最后,我们能在一个单个步骤产生一只完全的 Prrt2 猛烈猴子,表明在很快建立编辑基因的猴子模型的这条途径的实用性。 | Erwei Zuo Yi-Jun Cai Kui Li Yu Wei Bang-An Wang Yidi Sun Zhen Liu Jiwei Liu Xinde Hu Wei Wei Xiaona Huo Linyu Shi Cheng Tang Dan Liang Yan Wang Yan-Hong Nie Chen-Chen Zhang Xuan Yao Xing Wang Changyang Zhou Wenqin Ying Qifang Wang Ren-Chao Chen Qi Shen Guo-Liang Xu Jinsong Li Qiang Sun Zhi-Qi Xiong Hui Yang | 2017 | Cell Research2017，27，7： | 21 |
| 6 | MONOCULM 3,an Ortholog of WUSCHEL in Rice,Is Required for Tiller Bud Formation显示文摘WUSCHEL(WUS)plays an essential role for the maintenance of meristem activity in dicots,but its function is still elusive in monocots.We isolated a new monoculm mutant,monoculm 3(moc3),in which a point mutation causes the premature termination of rice O.sativa WUS(Os WUS).Morphological observation revealed that the formation of tiller buds was disrupted in moc3.MOC3 was localized in the nuclear and could interact with TOPLESS-RELATED PROTEINS(TPRs).The expression of MOC3 was induced by cytokinins and defection of MOC3 affected the expression of several two-component cytokinin response regulators,Os RRs and ORRs.Our results suggest that MOC3 is required for the formation of axillary buds and has a complex relationship with cytokinins. | Zefu Lu Gaoneng Shao Jinsong Xiong Yongqing Jiao Jing Wang Guifu Liu Xiangbing Meng Yan Liang Guosheng Xiong Yonghong Wang Jiayang Li | 2015 | Journal of Genetics and Genomics2015，42，2： | 17 |
| 7 | Tectonic Framework and Deep Structure of South China and Their Constraint to Oil-Gas Field Distribution显示文摘华南能在包围区域被划分成一稳定的 craton , Yangtze Craton ( YzC ),和几条 orogenic 带,那在北方是三叠纪的 Qinling-Dabie Orogenic 带( QDOB ),在西北的 Songpan-Garz ê Orogenic 带( SGOB ),在西方,在西南的 Youjiang Orogenic 带(出生年),在东南的中间的古生代的 Huanan Orogenic 带(壁炉内部的一锅架),和沿着海岸的中生代新生代海上的 Orogenic 带(乌合之众)的中生代新生代三河的 Orogenic 带( TOB )。地震 tomographic 图象表明莫霍深度比 40 km 深,岩石圈是在 YzC 下面厚的大约 210 km。SGOB 被厚外壳(>40 km ) 和薄岩石圈(<150 km ) 描绘。壁炉内部的一锅架,出生年和乌合之众有一个薄外壳(<40 km ) 和薄岩石圈(<150 km ) 。陆上的热流动调查分别地在 TOB 和乌合之众在东方 YzC 和西方的壁炉内部的一锅架和二个高热流动区域与一个低热流动区域揭示了一个分发模式。如此的“ high-low-high ”热流动分发模式能在 welling 上面源于新生代岩流圈。所有油气体地在 YzC 的中央部分被集中。残余油水池沿着 YzC 和它的邻近的 orogenic 带的南部的边缘被发现了。从地质、地球物理的结构,在有厚岩石圈和低热流动价值的华南的区域,以及弱变丑的一个观点,可能是为进一步的石油探索的理想的区域。 | WANG Qingchen LIU Jinsong DU Zhili CAI Liguo | 2009 | Acta Geologica Sinica(English Edition)2009，83，1： | 16 |
| 8 | Comparative profiling of genes and miRNAs expressed in the newborn, young adult, and aged human epididymides显示文摘在通过老化从出生后的开发在 epididymis 调整基因表示理解 transcriptional 因素和 miRNAs 的角色,在新生儿,年轻成年人,和年老的人表示的基因和 miRNAs 的系统的介绍 epididymides 被 cDNA 数组和 miRNA 数组分析分别地执行。新生的人的 epididymis 表示了 fewest mRNAs 但是 miRNAs 的最大的数字而成年、年老的 epididymides 表示了大多数 mRNAs 但是 fewest miRNAs,在 mRNAs 和 miRNA 之间的否定关联在老化期间。由综合分析,一套 miRNA 目标基于 miRNA 和 cDNA 数组被预言。在新生的 epididymis, 127 miRNAs 只或优先地被表示,但是仅仅 3 和 2 miRNAs 分别地在成年、年老的 epididymides 显示出一个充实年龄的表示模式。这研究在 epididymis 在基因表示的复杂规定上为进一步的研究象新卓见和基础一样提供一个基本数据库。 | Jinsong Zhang Qiang Liu Wei Zhang Jianyuan Li Zheng Li Zhongyi Tang Yixue Li Chunsheng Han Susan H. Hall Yonglian Zhang | 2010 | Acta Biochimica et Biophysica Sinica2010，42，2： | 15 |
| 9 | Tiller Bud Formation Regulators MOC1 and MOC3 Cooperatively Promote Tiller Bud Outgrowth by Activating F0N1 Expression in Rice显示文摘Tillering in rice is one of the most important agronomic traits.Rice tiller development can be divided into two main processes: the formation of the axillary bud and its subsequent outgrowth.Several genes critical for bud formation in rice have been identified by genetic studies;however,their molecular functions and relationships are still largely unknown.Here,we report that MONOCULM 1 (MOC1) and MONOCULM 3/ TILLERS ABSENT 1/STERILE AND REDUCED TILLERING 1 (MOC3/TAB1/SRT1),two vital regulators for tiller formation in rice,physically interact to regulate tiller bud outgrowth through upregulating the expression of FLORAL ORGAN NUMBER 1 (FON1),the homolog of CLAVATA1 in rice.We found that M0C3 is able to directly bind the promoter ofFONI and subsequently activate FON1 expression.MOC1 functions as a coactivator of MOC3,whereas it could not directly bind the FON1 promoter,and further activated FON1 expression in the presence of MOC3.Accordingly,FON1 is highly expressed at axillary meristems and shows remarkably decreased expression levels in mod and moc3 mutants.Loss-of-function mutants of FON1 exhibit normal bud formation but defective bud outgrowth and reduced tiller number.Collectively,these results shed light on a joint transcriptional regulatory mechanim by MOC1 and MOC3,and establish a new framework for the control of tiller bud formation and outgrowth. | Gaoneng Shao Zefu Lu Jinsong Xiong Bing Wang Yanhui Jing Xiangbing Meng Guifu Liu Haiyan Ma Yan Liang Fan Chen Yonghong Wang Jiayang Li Hong Yu | 2019 | Molecular Plant2019，12，8： | 15 |
| 10 | Zscan4 promotes genomic stability during reprogramming and dramatically improves the quality of iPS cells as demonstrated by tetraploid complementation显示文摘用 Yamanaka 因素产生的导致的 pluripotent 茎(iPS ) 细胞在自体同源的细胞治疗为使用有大潜力。然而, genomic 畸形充分在人的 iPS 房间,和房间不是的大多数老鼠 iPS 存在 pluripotent 由 tetraploid 互补试金评估了 TCA ) ;这很可能与 DNA 损坏反应(DDR ) 被联系在 Yamanaka 因素导致的早 reprogramming 发生了。相反,原子转移忠实地装改编体的房间进胚胎的茎(ES ) 满足 TCA 的房间。我们因此假设了涉及导致卵母细胞的 reprogramming 的因素可以在 reprogramming 期间稳定体的染色体,并且改进结果的 iPS 房间的质量。测试这个假设,我们在 iPS 期间为能减少的因素屏蔽了 DDR 信号房间正式就职。我们决定了那 Zscan4,在有 Yamanaka 因素的联合,不是仅仅显著地减少了 DDR 而且显著地支持了 iPS 房间产生的效率。Zscan4 的包括稳定了 genomic DNA,导致 p53 downregulation。而且, Zscan4 也提高了象通过 telomere 感染以后的 3 天一样早变长的 telomere 基于再结合的机制。作为结果,与 Zscan4 的增加产生的 iPS 房间比古典 iPS 房间展出了更长的 telomeres。惊人地,超过 50% iPS 房间线(11/19 ) 经由这生产了 “ Zscan4 protocol”产生了由 TCA 决定了的实时熊的 all-iPS 房间老鼠,与为用古典 Yamanaka 因素生产的线的 1/12 相比。我们的调查结果提供在 reprogramming 期间维持 genomic 稳定性支持的第一示范高质量的 iPS 房间的产生。 | Jing Jiang Wenjian Lv Xiaoying Ye Lingbo Wang Man Zhang Hui Yang Maja Okuka Chikai Zhou Xuan Zhang Lin Liu Jinsong Li | 2013 | Cell Research2013，23，1： | 14 |
| 11 | An Arabidopsis ABC Transporter Mediates Phosphate Deficiency-Induced Remodeling of Root Architecture by Modulating Iron Homeostasis in Roots显示文摘改变根建筑学是到磷酸盐(Pi ) 的植物的主要发展回答缺乏并且被认为在表层土为可得到的 Pi 提高一个植物能力到牧草。然而,控制这回答的内在的机制糟糕被理解。在这研究,我们识别了 Arabidopsis 异种, hps10 (对 Pi 饥饿 10 过分敏感) ,它在 Pi 足够的状况下面是词法上正常的,但是在 Pi 下面显示出主要的根生长和侧面的根的提高的生产的增加的抑制缺乏。hps10 是 ALUMINUM SENSITIVE3 (ALS3 ) 基因的以前识别的等位基因(als3-3 ) ,它涉及植物忍耐到铝毒性。我们的结果证明 ALS3 和它的交往的蛋白质 AtSTAR1 在 tonoplast 形成 ABC transporter 建筑群。这蛋白质建筑群调停一高度在 Xenopus 卵母细胞的 electrogenic 运输。在 Pi 缺乏下面, als3 比野类型在它的根积累 Fe 3+ 的高水平。在 Arabidopsis, LPR1 (低磷酸盐 ROOT1 ) 和 LPR2 编码 ferroxidases,当变异时,它在根和原因根生长减少 Fe 3+ 累积对 Pi 缺乏感觉迟钝。这里,我们提供证明 ALS3 与 LPR1/2 合作调整 Pi 的引人注目的证据在根的由 modulating Fe 动态平衡的根建筑学的导致缺乏的改变。 | Jinsong Dong Miguel A. PiSeros Xiaoxuan Li Haibing Yang Yu Liu Angus S. Murphy Leon V. Kochian Dong Liu | 2017 | Molecular Plant2017，10，2： | 13 |
| 12 | Eleven COVID-19 Outbreaks with Local Transmissions Caused by the Imported SARS-CoV-2 Delta VOC-China,July-August,2021显示文摘Starting from December 2019,Wuhan,China,encountered the first outbreak of coronavirus disease 2019(COVID-19)(1-2).The epidemic was successfully suppressed by strict containment so that the number of infected people was reduced to 0 on April 8,2020(3–4).After that,China experienced roughly 3 dozen outbreaks with local transmission caused by imported severe acute respiratory syndrome coronavirus 2(SARS-CoV-2). | Lei Zhou Kai Nie Hongting Zhao Xiang Zhao Bixiong Ye Ji Wang Cao Chen Hong Wang Jiangli Di Jinsong Li Chao Li Zhixiao Chen Ruiqi Ren Peihua Niu Hui Chen Tao Chen Yali Wang Lili Li Bingxue Han Ruhan A Si Chen Dan Li Dan Li Chunxia Jin Xin Zhang Jiangmei Liu Chunyu Xu Yecheng Yao Yenan Feng Zhili Li Bike Zhang Yang Song Peter Hao Yanping Zhang Hao Li Qun Li George F.Gao Guoqing Shi Wenbo Xu | 2021 | China CDC weekly2021，3，41： | 13 |
| 13 | Influence of catgut implantation at acupoints on leptin and insulin resistance in simple obesity rats显示文摘OBJECTIVES:To investigate the influence of catgut implantation at acupoints on leptin resistance(LR) and insulin resistance(IR) in the simple obesity rat.METHODS:Rats were made obese with high-fat diets,after which surgical catgut was implanted at Zusanli(ST 36) and Neiting(ST 44) acupoints once a week for 4 weeks(implantation group).Rats from the implantation group were compared with normal rats and unoperated obese rats(control group).Gene expression of the leptin receptor(OB-R) was evaluated using RT-PCR and northern blot.Serum and hypothalamus leptin and insulin(INS) levels were determined by radioimmunoassay.Body weight,Lee's index,body fat,serum and hypothalamus leptin and INS levels,and hypothalamic OB-R gene expression were determined before and after treatment.RESULTS:Body weights,Lee's index,body fat,and serum leptin and INS levels were significantly higher in obese than in normal rats.Hypothalamic leptin and INS levels and OB-R gene expression were significantly lower in obese rats.Catgut implantation at acupoint promoted weight loss and decreased serum leptin and INS levels.Hypothalamic leptin and INS levels and OB-R gene expression increased significantly.CONCLUSIONS:Catgut implantation at acupoint adjusts central and peripheral leptin and promotes hypothalamic OB-R gene expression.This may be an important method for regulation of LR,IR and abnormal endocrinology and metabolism. | Runhu Yan Xiaoming Liu Jie Bai Jiang Yu Jinsong Gu | 2012 | Journal of Traditional Chinese Medicine2012，32，3： | 12 |
| 14 | Relationships between vegetation and stomata,and between vegetation and pollen surface soil in Yunnan,Southwest China显示文摘Surface pollen and stomata of 61 samples collected in a study area ranging from tropical seasonal rainforest to oak forest(Quercus spinosa) in the Yulong Snow Mountain region in Yunnan,China,are used to distinguish vegetation communities.The results show that tropical seasonal rainforest(and mountain rainforest),south subtropical evergreen broad-leaved forest,and Quercus shrub are distinguished effectively from other vegetation types by analysis of surface pollen.The south subtropical evergreen broad-leaved forest,Pinus kesiya forest and evergreen broadleaf forest are distinguished effectively from other types of vegetation by pollen analysis.However,P.yunnanensis forest is not distinguished from other vegetation types,and P.armandii,P.densata forest and temperate deciduous conifer mixed forest are not distinguished.The over-representation of Pinus pollen is the main reason that these vegetation communities are not distinguished from each other.Conifer stomata analysis is an effective tool for identifying and distinguishing different types of coniferous forest,and this method performs well even with a small number of sampling points. | SHEN HuaDong LI ChunHai WAN HeWen TONG GuoBang LIU JinSong DAN Johnson | 2013 | Chinese Science Bulletin2013，58，15： | 12 |
| 15 | Optimal design of a new spatial 3-DOF parallel robot with respect to a frame-free index显示文摘Optimal design is one of the most important issues in robots. Since the very beginning, the concepts of the Jacobian matrix, manipulability and condition number, which are used successfully in the field of serial robots, have been applied to parallel robots. Unlike serial robots, parallel robots are good for motion/force transmission. Their performance evaluation and design should be correspondingly dif- ferent. This paper is an attempt to optimally design a novel spatial three-degree-of-freedom (3-DOF) parallel robot by using the concept of motion/force transmission. Accordingly, three indices are defined. The suggested indices are independent of any coordinate frame and could be applied to the analysis and design of a parallel robot whose singularities can be identified wholly by using the relative angle between the output and adjacent links, and by using the relative angle between the input and adjacent links. | JinSong Wang XinJun Liu Chao Wu | 2009 | Science China(Technological Sciences)2009，52，4： | 12 |
| 16 | High Strength Silicon Carbide Foams and Their Deformation Behavior显示文摘碳化矽(原文如此) 有连续地连接的开房间的结构的泡沫为他们的机械表演作好准备并且描绘。SiCfoams 的表观虎度在大约 0.4 和 1.3 g/cm^3 之间被控制,与相应压缩强度从从大约 8 ~ 30 MPa 的大约 13 ~ 60 MPa 和曲折力量。压缩测试原文如此,泡沫与仅仅一个线性橡皮的区域产出压力紧张曲线,它与在文学在陶器的泡沫上报导的那些不同。这能可能与好、稠密、高的力量微观结构被归因于细丝的存在。原文如此并且细丝对装载使用同类地作出回应。 | Chong TIAN Jinsong ZHANG Xiaoming CAO Qiang LIU Wanping HU | 2006 | Journal of Materials Science & Technology2006，22，2： | 11 |
| 17 | Radial profile of sap flow velocity in mature Xinjiang poplar(Populus alba L. var. pyramidalis) in Northwest China显示文摘Estimation of the transpiration rate for a tree is generally based on sap flow measurements within the hydro-active stem xylem. In this study, radial variation of sap flow velocity(Js) was investigated at five depths of the xylem(1, 2, 3, 5 and 8 cm under the cambium) in three mature Xinjiang poplar(Populus alba L. var. pyramidalis) trees grown at the Gansu Minqin National Studies Station for Desert Steppe Ecosystem from May to October 2011. Thermal dissipation probes of various lengths manufactured according to the Granier's design were installed into each tree for simultaneous observation of the radial patterns of Js through the xylem. The radial patterns were found to fit the four-parameter GaussAmp equation. The peak Js was about 27.02±0.95 kg/(dm2?d) at approximately 3 to 5 cm deep from the cambium of the three trees,and the lowest Js appeared at 1 cm deep in most of the time. Approximately 50% of the total sap flow in Xinjiang poplar occurred within one-third of the xylem from its outer radius, whereas 90% of the total sap flow occurred within two-fifth of the xylem. In addition, the innermost point of the xylem(at 8-cm depth), which appeared as the penultimate sap flow in most cases during the study period, was hydro-active with Js,8 of 7.55±3.83 kg/(dm2?d). The radial pattern of Js was found to be steeper in midday than in other time of the day, and steeper diurnal fluctuations were recorded in June, July and August(the mid-growing season). Maximum differences between the lowest Js(Js,1 or Js,8) and the highest Js(Js,3 or Js,5) from May through October were 12.41, 17.35, 16.30, 18.52, 12.60 and 16.04 g/(cm2?h), respectively. The time-dependent changes of Js along the radial profile(except at 1-cm depth) were strongly related to the reference evapotranspiration(ET0). Due to significant radial variability of Js, the mean daily sap flow at the whole-tree level could be over-estimated by up to 29.69% when only a single probe at depth of 2 cm was used. However, the accuracy of the estimation of sap flow in Xinjiang poplar could be significantly improved using a correction coefficient of 0.885. | HongZhong DANG TianShan ZHA JinSong ZHANG Wei LI ShiZeng LIU | 2014 | Journal of Arid Land2014，6，5： | 11 |
| 18 | EZH2-, CHD4-, and IDH-linked epigenetic perturbation and its association with survival in glioma patients显示文摘Glioma 是有有限治疗选择的复杂疾病。最近的进展在多达 80% 更低的等级 gliomas (LGG ) 并且在 76% 第二等的 glioblastomas (GBM ) 识别了 isocitrate 脱氢酶(IDH ) 变化。IDH 变化也在尖锐 myeloid 白血病(AML ) 的 10%-20% 被看见。在 AML,包含 epigenetic 规定的 IDH 和另外的基因的变化是早事件,这被决定,出现在 pre 白血病的干细胞(最低有效字符前) 上演,而在宣传 oncogenic 信号的基因的变化是在白血病的迟了的事件。IDH 变化也是在 glioma 的早事件,发生在 TP53 变化前, 1p/19q 删除,等等。尽管有在 glioma 研究的这些进展,进另外的分子的改变的研究更加落后。在这研究,我们分析了当前可得到的数据库。我们除了已知的基因 IDH1/2 在 glioma 识别了 EZH2, KMT2C,和 CHD4 同样重要的基因。我们也证明 PIK3CA, CDKN2A, CDK4, FIP1L1,或 FUBP1 的 genomic 改变与 IDH 变化协作否定地在 LGG 影响病人幸存。在有 TP53 变化或 IDH1/2 变化的 LGG 病人,没有如此的改变, EZH2, KMC2C,和 CHD4 的另外的 genomic 改变个别地或在联合比病人与显著地减少的没有疾病的幸存被联系。在基因水平或蛋白质水平的 EZH2, KMT2C,和 CHD4 的改变能使不安 epigenetic 节目,在 glioma 导致恶意的转变。由在可得到的数据集上在 AML 和 glioma 和表现生物信息学分析上考察当前的文学,我们从 premalignant 干细胞在 tumorigenesis 上开发了一个假想模型到 glioma。 | Le Zhang Ying Liu Mengning Wang Zhenhai Wu Na Li Jinsong Zhang Chuanwei Yang | 2017 | Journal of Molecular Cell Biology2017，9，6： | 11 |
| 19 | Geophysical methods for the study of sedimentary cycles显示文摘We present the wavelet depth-frequency analysis and variable-scale frequency cycle analysis methods to study sedimentary cycles.The spectrum analysis,variable-scale frequency cycle analysis, and wavelet depth-frequency analysis methods are mainly discussed to distinguish sedimentary cycles of different levels.The spectrum analysis method established the relationship between the spectrum characteristics and the thickness and number of sedimentary cycles.Both the variable-scale frequency cycle analysis and the wavelet depth-frequency analysis are based on the wavelet transform.The variable-scale frequency cycle analysis is used to obtain the relationship between the periodic changes of frequency in different scales and sedimentary cycles,and the wavelet depth-frequency analysis is used to obtain the relationship between migration changes of frequency energy clusters and sedimentary cycles. We designed a software system to process actual logging data from the Changqing Oilfield to analyze the sedimentary cycles,which verified the effectiveness of the three methods,and good results were obtained. | Xu Jingling Liu Luofu Wang Guiwen Shen Jinsong Zhang Chunhua | 2009 | Petroleum Science2009，6，3： | 10 |
| 20 | Rapid genomic changes in polyploid wheat and related species:implications for genome evolution and genetic improvement显示文摘A polyploid organism by possessing more than two sets of chromosomes from one species (autopolyploidy) or two or more species (allopolyploidy) is known to have evolutionary advantages. However, by what means a polyploid accommodates increased genetic dosage or divergent genomes (allopolyploidy) in one cell nucleus and cytoplasm constitutes an enormous challenge. Recent years have witnessed efforts and progress in exploring the possible mechanisms by which these seemingly intangible hurdles of polyploidy may be ameliorated or eventually overcome. In particular, the documentation of rapid and extensive non-Mendelian genetic and epigenetic changes that often accompany nascent polyploidy is revealing: the resulting non-additive and novel gene expression at global, regional and local levels, and timely restoration of meiotic chromosomal behavior towards bivalent pairing and disomic inheritance may ensure rapid establishment and stabilization as well as its long-term evolutionary success. Further elucidation on these novel mechanisms underpinning polyploidy will promote our understanding on fundamental issues in evolutionary biology and in our manipulation capacities in future genetic improvement of important crops that are currently polyploids in genomic constitution. This review is intended to provide an updated discussion on these interesting and important issues within the scope of a specific yet one of the most important plant groups-polyploid wheat and its related species. | Bao Liu Chunming Xu Na Zhao Bao Qi Josphert N. Kimatu Jinsong Pang Fangpu Han | 2009 | Journal of Genetics and Genomics2009，36，9： | 10 |
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