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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Two-dimensional metal-organic-framework as a unique theranostic nano-platform for nuclear imaging and chemo-photodynamic cancer therapy显示文摘Nanoscale metal organic frameworks (NMOFs) with porous structure and inherent biodegradability are attractive nanomedicine platforms.In addition to conventional particulate NMOFs,two-dimensional (2D) NMOFs are emerging as a unique type of NMOFs which however have been relatively less explored for nanomedicine applications.Herein,2D NMOFs composed of Zn2+ and tetrakis(4-carboxyphenyl) porphyrin (TCPP) are fabricated and functionalized with polyethylene glycol (PEG).Compared to their particulate counterpart,such 2D NMOFs show greatly increased drug loading capacity and enhanced light-triggered singlet oxygen production,promising for chemotherapy and photodynamic therapy (PDT),respectively.Utilizing the porphyrin structure of TCPP,our 2D NMOFs could be labeled with a diagnostic radioisotope,99mTc,for single photon emission computer tomography (SPECT) imaging,which reveals efficient tumor homing of those 2D NMOFs upon intravenous injection.While offering a remarkable synergistic in vivo antitumor effect for the combined chemo-PDT,such 2D NMOFs show efficient biodegradation and rapid renal clearance.Our work presents the great promise of 2D NMOFs for nanomedicine applications. | Wenjun Zhu Yu Yang Qiutong Jin Yu Chao Longlong Tian Jingjing Liu Ziliang Dong Zhuang Liu | 2019 | Nano Research2019，12，6： | 9 |
| 3 | Advances in graphene reinforced metal matrix nanocomposites:Mechanisms,processing,modelling,properties and applications显示文摘Graphene has been extensively explored to enhance functional and mechanical properties of metalmatrix nanocomposites for wide-range applications due to their superior mechanical,electrical and thermal properties.This article discusses recent advances of key mechanisms,synthesis,manufacture,modelling and applications of graphene metal matrix nanocomposites.The main strengthening mechanisms include load transfer,Orowan cycle,thermal mismatch,and refinement strengthening.Synthesis technologies are discussed including some conventional methods(such as liquid metallurgy,powdermetallurgy,thermal spraying and deposition technology)and some advanced processing methods(such as molecular-level mixing and friction stir processing).Analytical modelling(including phenomenological models,semi-empirical models,homogenization models,and self-consistent model)and numerical simulations(including finite elements method,finite difference method,and boundary element method)have been discussed for understanding the interface bonding and performance characteristics between graphene and different metal matrices(Al,Cu,Mg,Ni).Key challenges in applying graphene as a reinforcing component for the metal matrix composites and the potential solutions as well as prospectives of future development and opportunities are highlighted. | Wenge Chen Tao Yang Longlong Dong Ahmed Elmasry Jiulong Song Nan Deng Ahmed Elmarakbi Terence Liu Hai Bao Lv Yong Qing Fu | 2020 | Nanotechnology and Precision Engineering2020，3，4： | 4 |
| 4 | CaCO3-Assisted Preparation of pH-Responsive Immune-Modulating Nanoparticles for Augmented Chemo-Immunotherapy显示文摘Due to the negative roles of tumor microenvironment(TME)in compromising therapeutic responses of various cancer therapies,it is expected that modulation of TME may be able to enhance the therapeutic responses during cancer treatment.Herein,we develop a concise strategy to prepare pH-responsive nanoparticles via the CaCO3-assisted double emulsion method,thereby enabling effective co-encapsulation of both doxorubicin(DOX),an immunogenic cell death(ICD)inducer,and alkylated NLG919(aNLG919),an inhibitor of indoleamine 2,3-dioxygenase 1(IDO1).The obtained DOX/aNLG919-loaded CaCO3 nanoparticles(DNCaNPs)are able to cause effective ICD of cancer cells and at the same time restrict the production of immunosuppressive kynurenine by inhibiting IDO1.Upon intravenous injection,such DNCaNPs show efficient tumor accumulation,improved tumor penetration of therapeutics and neutralization of acidic TME.As a result,those DNCaNPs can elicit effective anti-tumor immune responses featured in increased density of tumor-infiltrating CD8+cytotoxic T cells as well as depletion of immunosuppressive regulatory T cells(Tregs),thus effectively suppressing the growth of subcutaneous CT26 and orthotopic 4T1 tumors on the Balb/c mice through combined chemotherapy&immunotherapy.This study presents a compendious strategy for construction of pH-responsive nanoparticles,endowing significantly enhanced chemo-immunotherapy of cancer by overcoming the immunosuppressive TME. | Yujie Zhu Zhijuan Yang Ziliang Dong Yimou Gong Yu Hao Longlong Tian Xianzhu Yang Zhuang Liu Liangzhu Feng | 2021 | Nano-Micro Letters2021，13，2： | 3 |
| 5 | Effect of temperature and solid concentration on anaerobic digestion of rice straw in South China显示文摘 | Li Lianhua Li Dong Sun Yongming Ma Longlong Yuan Zhenhong Kong Xisoying | 2010 | International Journal of Hydrogen Energy2010，35，13： | 1 |
| 6 | Effect of temperature and solid concentration on anaerobic digestion of rice straw in South China显示文摘 | Li Lianhua Li Dong Sun Yongming Ma Longlong Yuan Zhenhong Kong Xiaoying | 2010 | International Journal of Hydrogen Energy2010，，13： | 1 |
| 7 | Py-GC/MS study of lignin pyrolysis and effect of catalysts on product distribution显示文摘Fast pyrolysis is one of the most promising methods to convert lignin into fuels and chemicals.In the present study,pyrolysis-gas chromatography/mass spectrometry(Py-GC/MS)was used to evaluate vapor phase product distribution of lignin fast pyrolysis.During the non-catalytic pyrolysis process,lignin was pyrolyzed at 400℃,500℃ and 600℃ respectively,finding that the highest yield of aromatic hydrocarbons was obtained at 600℃.Catalytic pyrolysis experiments were also conducted to investigate the effects of catalyst pore structure and acidity on the product distributions.Five different catalysts(HZSM-5,MCM-41,TiO_(2),ZrO_(2) and Mg(Al)O)were applied to lignin catalytic pyrolysis,and the catalytic performance was estimated by analyzing the pyrolytic products.The catalysts were characterized by using X-ray diffraction(XRD),BET,and NH3(CO_(2))temperature programmed desorption.Based on these characterizations,discussion was carried out to explain the formation of the produc distributions.Among the five catalysts,HZSM-5 exhibited the best performance on the formation of aromatic hydrocarbons. | Si Zhan Wang Chenguang Bi Kang Zhang Xinghua Yu Chiling Dong Renjie Ma Longlong Pang Changle | 2017 | International Journal of Agricultural and Biological Engineering2017，10，5： | 1 |
| 8 | Application of EEG multipole model in the diagnosis of Alzheimer's disease显示文摘In order to find the electroencephalogram (EEG) characteristic parameters typical of Alzheimer’s disease (AD) and explore an effec- tive diagnostic method, a new mobile current multipole model was proposed to simulate the AD patient’s cortical dipole source activities. The indicators of goodness of fit (GOF) and DtononD (DD) were calculated from EEG samples to evaluate the performance of this model. Relevant results showed that this multipole model with higher GOF values and larger DD change well fitted the pathological elec- trical activities of cortical neurons aroused by AD’s extended sulcus and gyrus in the cerebral cortex. Meanwhile, the products of DD mean & standard variance were found in a clear linear correlation with the diagnostic data of mini-mental state examination (MMSE) used in AD clinics. Furthermore, by tracing this multipole model’s indicators in typical patients and contrasting with the functional mag- netic resonance image (fMRI) as AD progressed, we suggested that the DD index may be suitable for monitoring the AD developments as a new diagnostic parameter. | Baikun Wan Longlong Cheng Xia Hu Dong Ming | 2008 | Progress in Natural Science:Materials International2008，18，1： | 0 |
| 9 | Suicide Deaths in China:An Analysis of Forensic Cases显示文摘Suicide cases are often encountered during death investigations in forensic medicine.In this study,through a comparative analysis of our own data of 98 suicide cases and previous reports from various forensic institutions in China,we analyzed the risk factors of Chinese suicides and explored the implications thereof from a forensic point of view.Moreover,the age and sex differences,means,causes,and other concerns regarding suicide are discussed along with a review of the literature. | Dong Zhao Longlong Wang Kun Wang Zhimin Wang Eradil Orazhkan | 2016 | Journal of Forensic Science and Medicine2016，2，3： | 0 |
| 10 | Rapid fatty acids detection of vegetable oils by Raman spectroscopy based on competitive adaptive reweighted sampling coupled with support vector regression显示文摘Objectives:The composition and content of fatty acids are critical indicators of vegetable oil quality.To overcome the drawbacks of traditional detection methods,Raman spectroscopy was investigated for the fast determination of the fatty acids composition of oil.Materials and Methods:Rapeseed and soybean oil at different depths of the oil tank at different storage times were collected and an eighth-degree polynomial function was used to fit the Raman spectrum.Then,the multivariate scattering correction,standard normal variable transformation(SNV),and Savitzky–Golay convolution smoothing methods were compared.Results:Polynomial fitting combined with SNV was found to be the optimal pretreatment method.Characteristic wavelengths were selected by competitive adaptive reweighted sampling.For monounsaturated fatty acids(MUFAs),polyunsaturated fatty acids(PUFAs),and saturated fatty acids(SFAs),44,75,and 92 characteristic wavelengths of rapeseed oil,and 60,114,and 60 characteristic wavelengths of soybean oil were extracted.Support vector regression was used to establish the prediction model.The R^(2)values of the prediction results of MUFAs,PUFAs,and SFAs for rapeseed oil were 0.9670,0.9568,and 0.9553,and the root mean square error(RMSE)values were 0.0273,0.0326,and 0.0340,respectively.The R^(2)values of the prediction results of fatty acids for soybean oil were respectively 0.9414,0.9562,and 0.9422,and RMSE values were 0.0460,0.0378,and 0.0548,respectively.A good correlation coefficient and small RMSE value were obtained,indicating the results to be highly accurate and reliable.Conclusions:Raman spectroscopy,based on competitive adaptive reweighted sampling coupled with support vector regression,can rapidly and accurately analyze the fatty acid composition of vegetable oil. | Linjiang Pang Hui Chen Liqing Yin Jiyu Cheng Jiande Jin Honghui Zhao Zhihao Liu Longlong Dong Huichun Yu Xinghua Lu | 2022 | Food Quality and Safety2022，6，4： | 0 |
| 11 | Influence of V/P Ratio on the Catalytic Performance of VPO/SiO_2 Catalysts for Ammoxidation of Chloro-Substituted Toluenes显示文摘A series of vanadium phosphate oxide(VPO) catalysts supported on silica(VPO/Si O2) with various mole ratios of V/P(nV:nP=1:0.8-1:3) were prepared through impregnation method. The catalytic activity was evaluated by ammoxidation reactions of several kinds of chloro-substituted toluenes(CT) in a fixed-bed reactor. The catalyst presented the best performance when nV:nP is 1:1.6. The prepared catalysts were characterized by N2 adsorption, hydrogen temperature programmed reduction(TPR) and ammonia temperature programmed desorption(TPD) and etc. The results reveal that P can decrease the bonding energy of V=O and increase the mobility of lattice oxygen which was beneficial for the improvement of the catalysts, while too much P can greatly decrease the average oxidation number of V which leads to deactivation of the catalysts. The surface acidity of the VPO/Si O2 catalysts is affected by nV:nP and the catalyst had the highest surface acidity when nV:nP is 1:1.6. The selectivity of catalysts is proportional to the surface acidity when nV:nP is lower than 1:3.0. | DONG Yanling XU Longlong ZHANG Zhenguo LIU Wenhui LI Xiongjian ZHONG Yalan HUANG Chi | 2019 | Wuhan University Journal of Natural Sciences2019，24，1： | 0 |
| 12 | A 70%-power transmission efficiency, 3.39 Mbps power and data telemetry over a single 13.56 MHz inductive link for biomedical implants显示文摘The application of wireless power and data telemetry to implantable medical devices(IMDs)has grown dramatically in recent decades. Achieving a high data rate and high-power transmission efficiency(PTE) over the same inductive link remains challenging. This paper presents a power and data telemetry circuit over a single 13.56 MHz inductive link. On the transmitter(TX) side, a binary-phase-shift keying(BPSK) modulation based on a Class-E amplifier that features a high modulation rate and a high quality(Q)-factor is proposed. A digital-assisted phase-locked-loop(PLL) is proposed on the receiver(RX) side as a BPSK demodulator to handle the long settling process. The maximum data rate can be extended to 1/4 of the carrier frequency. The prototype has been fabricated with a 180 nm BCD(Bipolar-CMOS-DMOS)process. The measurement shows that up to 31.25 mW of power can be delivered simultaneously with 3.39-Mbps of data transmission, while a 2×10^(-7)bit-error-rate(BER) can be ensured over a transmission distance of 5 mm. The peak PTE is 70%, whereas the RX energy efficiency is 183 p J/bit. The results demonstrate the potential of the proposed techniques in applications to various biomedical implants with intensive bandwidth and energy efficiency requirements. | Mingyi CHEN Luominghao PAN Qiuyang LIN Longlong CHENG Dong MING | 2023 | Science China(Information Sciences)2023，66，2： | 0 |
| 13 | Optimization and applications of an in vivo bioluminescence imaging model of influenza A virus infections显示文摘Dear Editor,In vivo bioluminescence imaging(BLI)models of virus infection possess unique advantages over conventional assays.For instance,the BLI model enables rapid and real-time detection of viral load and dissemination in the same animal over time(Mehle,2015;Wen et al.,2022). | Xiaojing Lin Murong Zhu Xiujuan Zhao Longlong Si Meiyue Dong Varada Anirudhan Qinghua Cui Lijun Rong Ruikun Du | 2023 | Virologica Sinica2023，38，4： | 0 |
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