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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | More than Carbon Stocks:A Case Study of Ecosystem-based Benefits of REDD+ in Indonesia显示文摘During the 15th Conference of the Parties(COP 15),Parties agreed that reducing emissions from deforestation and forest degradation and enhancing 'removals of greenhouse gas emission by forests'(REDD+) in developing countries through positive incentives under the United Nations Framework Convention on Climate Change(UNFCCC) was capable of dealing with global emissions.As REDD+ seeks to lower emissions by stopping deforestation and forest degradation with an international payment tier according to baseline scenarios,opportunities for ecosystem benefits such as slowing habitat fragmentation,conservation of forest biodiversity,soil conservation may be also part of this effort.The primary objective of this study is to evaluate ecosystem-based benefits of REDD+,and to identify the relationships with carbon stock changes.To achieve this goal,high resolution satellite images are combined with Normalized Difference Vegetation Index(NDVI) to identify historical deforestation in study area of Central Kalimantan,Indonesia.The carbon emissions for the period of 2000-2005 and 2005-2009 are 2.73 × 10 5 t CO 2 and 1.47 × 10 6 t CO 2 respectively,showing an increasing trend in recent years.Dring 2005-2009,number of patches(NP),patch density(PD),mean shape index distribution(SHAPE_MN) increased 30.8%,30.7% and 7.6%.Meanwhile,largest patch index(LPI),mean area(AREA_MN),area-weighted mean of shape index distribution(SHAPE_AM),neighbor distance(ENN_MN) and interspersion and juxtaposition index(IJI) decreased by 55.3%,29.7%,15.8%,53.4% and 21.5% respectively.The area regarding as positive correlation between carbon emissions and soil erosion was approximately 8.9 × 10 3 ha corresponding to 96.0% of the changing forest.These results support the view that there are strong synergies among carbon loss,forest fragmentation and soil erosion in tropical forests.Such mechanism of REDD+ is likely to present opportunities for multiple benefits that fall outside the scope of carbon stocks. | LU Heli YAN Weiyang QINYaochen LIU Guifang | 2012 | Chinese Geographical Science2012，22，4： | 6 |
| 3 | Blocking the JAK2/STAT3 and ERK pathways suppresses the proliferation of gastrointestinal cancers by inducing apoptosis显示文摘Dysregulated crosstalk between different signaling pathways contributes to tumor development,including resistance to cancer therapy.In the present study,we found that the mitogen-activated extracellular signal-regulated kinase(MEK)inhibitor trametinib failed to suppress the proliferation of PANC-1 and MGC803 cells by activating the Janus kinase 2(JAK2)/signal transducer and activator of transcription 3(STAT3)signaling pathway,while the JAK2 inhibitor fedratinib failed to inhibit the growth of the PANC-1 cells upon stimulation of extracellular signal-regulated kinase(ERK)signaling.In particular,the most prominent enhancement of the anti-proliferative effect resulted from the concurrent blockage of the JAK2/STAT3 and ERK signaling pathways.Furthermore,the combination of the two inhibitors resulted in a reduced tumor burden in mice.Our evidence suggests novel crosstalk between JAK2/STAT3 and ERK signaling in gastric cancer(GC)and pancreatic ductal adenocarcinoma(PDAC)cells and provides a therapeutic strategy to overcome potential resistance in gastrointestinal cancer. | Xi WANG Chunyan DAI Yifei YIN Lin WU Weiyang JIN Yufei FU Zhe CHEN Ke HAO Bin LU | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，6： | 4 |
| 4 | Phosphorylation of a wheat aquaporin at two sites enhances both plant growth and defense显示文摘Eukaryotic aquaporins share the characteristic of functional multiplicity in transporting distinct substrates and regulating various processes,but the underlying molecular basis for this is largely unknown.Here,we report that the wheat(Triticum aestivum)aquaporin TaPIP2;10 undergoes phosphorylation to promote photosynthesis and productivity and to confer innate immunity against pathogens and a generalist aphid pest.In response to elevated atmospheric CO_(2)concentrations,TaPIP2;10 is phosphorylated at the serine residue S280 and thereafter transports CO_(2)into wheat cells,resulting in enhanced photosynthesis and increased grain yield.In response to apoplastic H_(2)O_(2) induced by pathogen or insect attacks,TaPIP2;10 is phosphorylated at S121 and this phosphorylated form transports H_(2)O_(2) into the cytoplasm,where H_(2)O_(2)intensifies host defenses,restricting further attacks.Wheat resistance and grain yield could be simultaneously increased by TaPIP2;10 overexpression or by expressing a TaPIP2;10 phosphomimic with aspartic acid substitutions at S121 and S280,thereby improving both crop productivity and immunity. | Kai Lu Xiaochen Chen Xiaohui Yao Yuyan An Xuan Wang Lina Qin Xiaoxu Li Zuodong Wang Shuo Liu Zhimao Sun Liyuan Zhang Lei Chen Baoyan Li Baoyou Liu Weiyang Wang Xinhua Ding Yonghua Yang Meixiang Zhang Shenshen Zou Hansong Dong | 2022 | Molecular Plant2022，15，11： | 2 |
| 5 | Feature extraction with discrete wavelet transform for drill wear monitoring 显示文摘 | Sun Qiao Tang Ying Lu Weiyang | 2005 | Journal of Vibration and Control2005，11，11： | 1 |
| 6 | The potential use of GABAergic drugs in the treatment of asthma显示文摘 | LU Weiyang | 2011 | Future Medicinal Chemistry2011，3，2： | 1 |
| 7 | Expression for peroxisome proliferator-activated receptor gamma in pituitary adenomas 38 cases for semi-quantitative immunohistochemical analysis显示文摘BACKGROUND: It has been reported that peroxisome proliferator-activated receptor γ(PPARγ) is highly expressed in lung cancer, colon cancer, and gastric cancer, as well as other tumors. OBJECTIVE: To study expression of PPARγin pituitary adenomas and analyze the role of PPARγin hormonal typing of pituitary adenomas. DESIGN, TIME AND SETTING: Semi-quantitative immunohistochemistry of pathological specimens. The experiment was conducted at the Department of Neurosurgery, Wuxi Second Hospital Affiliated to Nanjing Medical University between January 2002 and May 2005. MATERIALS: Surgical resection samples of pituitary adenomas from 38 cases (18 male and 20 female) were analyzed. Eight cases were determined to be invasive pituitary adenomas and 30 cases were non-invasive pituitary adenomas. Hormonal classification of the types of pituitary adenomas revealed somatotrophic adenomas in six cases, corticotrophic adenoma in five cases, prolactinomas in 13 cases, multi-hormone secreting adenomas in six cases, and eight cases of adenoma without altered endocrine function. Five autopsy specimens were collected during the same period from patients of matching age that died from unrelated diseases and were included as normal anterior pituitary controls. METHODS: Cell counts for positive immunohistochemical signals were recorded from histopathological sections. The percentage of positive cells was reported as a semi-quantitative analysis. MAIN OUTCOME MEASURES: The rate of PPARγpositive cells in different types of adenoma was based on hormonal levels and invasiveness of pituitary tumor cells. RESULTS: All tumor biopsies were determined to express PPARγ The rate of PPARγ-positive cells ranged between 8%-65% in the pituitary adenomas. According to hormonal type, PPARγexpression did not vary between the groups. In addition, there was no significant difference in PPARγexpression between the non-invasive and invasive pituitary adenomas. CONCLUSIONS: Human pituitary adenomas express PPARγ, and this expression is unrelated to hormonal type and invasiveness. | Xiaojie Lu Kailai Chen Weiyang Ji Qing Wang Bing Li Jiang'an Li Jiyong Sun | 2008 | Neural Regeneration Research2008，3，7： | 1 |
| 8 | The potential use of GABAergic drugs in the treatmentof asthma显示文摘 | LU Weiyang | 2011 | Future Med Chem2011，3，2： | 1 |
| 9 | Comparison of chemical compositions of Ilex latifolia Thumb and Camellia sinensis L显示文摘 | LIANG Yuerong MA Weiyang LU Jianliang | | 0，，： | 1 |
| 10 | Energy hole solution algorithm in wireless sensor network显示文摘 | LU Yuting Wang Weiyang | 2014 | Journal of Networks2014，9，4： | 1 |
| 11 | Scientific objectives of the Hot Universe Baryon Surveyor(HUBS) mission显示文摘The Hot Universe Baryon Surveyor(HUBS) is a proposed space-based X-ray telescope for detecting X-ray emissions from the hot gas content in our universe. With its unprecedented spatially-resolved high-resolution spectroscopy and large field of view,the HUBS mission will be uniquely qualified to measure the physical and chemical properties of the hot gas in the interstellar medium, the circumgalactic medium, the intergalactic medium, and the intracluster medium. These measurements will be valuable for two key scientific goals of HUBS, namely to unravel the AGN and stellar feedback physics that governs the formation and evolution of galaxies, and to probe the baryon budget and multi-phase states from galactic to cosmological scales. In addition to these two goals, the HUBS mission will also help us solve some problems in the fields of galaxy clusters, AGNs, difuse X-ray backgrounds, supernova remnants, and compact objects. This paper discusses the perspective of advancing these fields using the HUBS telescope. | Joel Bregman Renyue Cen Yang Chen Wei Cui Taotao Fang Fulai Guo Edmund Hodges-Kluck Rui Huang Luis C.Ho Li Ji Suoqing Ji Xi Kang Xiaoyu Lai Hui Li Jiangtao Li Miao Li Xiangdong Li Yuan Li Zhaosheng Li Guiyun Liang Helei Liu Wenhao Liu Fangjun Lu Junjie Mao Gabriele Ponti Zhijie Qu Chenxi Shan Lijing Shao Fangzheng Shi Xinwen Shu Lei Sun Mouyuan Sun Hao Tong Junfeng Wang Junxian Wang Q.Daniel Wang Song Wang Tinggui Wang Weiyang Wang Zhongxiang Wang Dandan Xu Haiguang Xu Heng Xu Renxin Xu Xiaojie Xu Yongquan Xue Hang Yang Feng Yuan Shuinai Zhang Yuning Zhang Zhongli Zhang Yuanyuan Zhao Enping Zhou Ping Zhou | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，9： | 1 |
| 12 | Rosuvastatin, Identified From a Zebrafish Chemical Genetic Screen for Antiangiogenic Compounds, Suppresses the Growth of Prostate Cancer显示文摘 | Chunyang Wang Weiyang Tao Youdong Wang Jennifer Bikow Bingxin Lu Armand Keating Subodh Verma Thomas G. Parker Ruifa Han Xiao-Yan Wen | 2010 | European Urology2010，，3： | 1 |
| 13 | Computational screening and design of nanoporous membranes for efficient carbon isotope separation显示文摘Stable isotopes have been routinely used in chemical sciences,medical treatment and agricultural research.Conventional technologies to produce high-purity isotopes entail lengthy separation processes that often suffer from low selectivity and poor energy efficiency.Recent advances in nanoporous materials open up new opportunities for more efficient isotope enrichment and separation as the pore size and local chemical environment of such materials can be engineered with atomic precision.In this work,we demonstrate the unique capability of nanoporous membranes for the separation of stable carbon isotopes by computational screening a materials database consisting of 12,478 computation-ready,experimental metal-organic frameworks(MOFs).Nanoporous materials with the highest selectivity and membrane performance scores have been identified for separation of^(12)CH_4/^(13)CH_4 at the ambient condition(300 K).Analyzing the structural features and metal sites of the promising MOF candidates offers useful insights into membrane design to further improve the performance.An upper limit of the efficiency has been identified for the separation of^(12)CH_4/^(13)CH_4 with the existing MOFs and those variations by replacement of the metal sites. | Jingqi Wang Musen Zhou Diannan Lu Weiyang Fei Jianzhong Wu | 2020 | Green Energy & Environment2020，5，3： | 1 |
| 14 | 原肠运动中期细胞谱系与细胞命运的空间转录组特征显示文摘哺乳动物的早期胚胎发育,特别是着床后原肠运动过程中,多能性干细胞通过多个层次的细胞命运决定,形成了胚胎器官发生、形态建成的整个发育蓝图,是生命体最重要的分子事件之一。 | Guangdun Peng Shengbao Suo Jun Chen Weiyang Chen Chang Liu Fang Yu Ran Wang Shirui Chen Na Sun Guizhong Cui Lu Song Patrick P.L.Tam 韩敬东 景乃禾 | 2017 | 科学新闻2017，0，4： | 0 |
| 15 | Trophic Mode-Dependent Proteomic Analysis Reveals Functional Significance of Light- Independent Chlorophyll Synthesis in Synechocystis sp. PCC 6803显示文摘光合的模型有机体 Synechocystis sp。PCC 6803 能在不同营养的模式成长,取决于光和外长的器官的碳来源的可获得性。然而,便于房间差别的蛋白质侧面变化怎么在不同模式宣传,包括地没被调查。用等压的基于标签的量的 proteomics,我们同时识别了并且确定越过四个不同营养的模式的 45% Synechocystis proteome,即,自造营养物质,不是自养, photoheterotrophic,和 mixotrophic 模式。在是越过四个营养的模式表示的差别的 155 蛋白质之中,涉及氮吸收和光无关的叶绿素合成的蛋白质是戏剧性地在 mixotrophic 模式的 upregulated,有 P 察觉到的 II phosphorylation 碳和氮吸收地位。而且,用在光无关的叶绿素合成的一个变异的有缺陷者的功能的学习表明这条小径为在骑车的光 / 黑暗的照明政体下面的叶绿素累积是重要的,一条件 mimicking 天 / 夜里在某些自然产地骑车。一起,这些结果在 cyanobacterium 在营养的模式依赖者蛋白质表示上提供最全面的信息,并且在营养的生长揭示光无关的叶绿素合成的功能的意义。 | Longfa Fang Haitao Ge Xiahe Huana Ye Liu Min Lu Jinlong Wang Weiyang Chen Wu Xu Yingchun Wang | 2017 | Molecular Plant2017，10，1： | 0 |
| 16 | Pulsar giant pulse: Coherent instability near light cylinder显示文摘Giant pulses(GPs) are extremely bright individual pulses of radio pulsar. In microbursts of Crab pulsar, which is an active GP emitter, zebra-pattern-like spectral structures are observed, which are reminiscent of the 'zebra bands' that are observed in type Ⅳ solar radio flares. However, band spacing linearly increases with the band center frequency of ~5-30 GHz. In this study, we propose that the Crab pulsar GP can originate from the coherent instability of plasma near a light cylinder. Further, the growth of coherent instability can be attributed to the resonance observed between the cyclotron-resonant-excited wave and the background plasma oscillation. The particles can be injected into the closed-field line regions owing to magnetic reconnection near a light cylinder. These particles introduce a large amount of free energy that further causes cyclotron-resonant instability, which grows and amplifies radiative waves at frequencies close to the electron cyclotron harmonics that exhibit zebra-pattern-like spectral band structures. Further, these structures can be modulated by the resonance between the cyclotron-resonant-excited wave and the background plasma oscillation. In this scenario, the band structures of the Crab pulsar can be well fitted by a coherent instability model, where the plasma density of a light cylinder should be ~10^(13-15) cm^(-3), with an estimated gradient of >5.5 × 10~5 cm^(-4). This process may be accompanied by high-energy emissions. Similar phenomena are expected to be detected in other types of GP sources that have magnetic fields of ? 106 G in a light cylinder. | WeiYang Wang JiGuang Lu SongBo Zhang XueLei Chen Rui Luo RenXin Xu | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，7： | 0 |
| 17 | The quantitative proteome atlas of a model cyanobacterium显示文摘Cyanobacteria are a group of oxygenic photosynthetic bacteria with great potentials in biotechnological applications and advantages as models for photosynthesis research. The subcellular localizations of the majority of proteins in any cyanobacteria remain undetermined, representing a major challenge in using cyanobacteria for both basic and industrial researches. Here, using label-free quantitative proteomics, we map 2027 proteins of Synechocystis sp. PCC6803, a model cyanobacterium, to different subcellular compartments and generate a proteome atlas with such information. The atlas leads to numerous unexpected but important findings, including the predominant localization of the histidine kinases Hik33 and Hik27 on the thylakoid but not the plasma membrane. Such information completely changes the concept regarding how the two kinases are activated. Together, the atlas provides subcellular localization information for nearly 60% proteome of a model cyanobacterium, and will serve as an important resource for the cyanobacterial research community. | Jinlong Wang Xiahe Huang Haitao Ge Yan Wang Weiyang Chen Limin Zheng Chengcheng Huang Haomeng Yang Lingyu Li Na Sui Yu Wang Yuanya Zhang Dandan Lu Longfa Fang Wu Xu Yuqiang Jiang Fang Huang Yingchun Wang | 2022 | Journal of Genetics and Genomics2022，49，2： | 0 |
| 18 | Spatial and temporal distributions of mercury species and controlling factors in Hongfeng Reservoir, Guizhou, China显示文摘 | Tianrong HE Xinbin FENG Guangle QIU Weiyang BAI Zhonggen LI Julia LU | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 0 |
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