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| 1 | Drug-Eluting Balloon versus New-Generation Drug-Eluting Stent for the Treatment of In-Stent Restenosis: An Updated Systematic Review and Meta-Analysis显示文摘 | Kong-Yong Cui Shu-Zheng Lyu Min Zhang Xian-Tao Song Fei Yuan Feng Xu | 2018 | Chinese Medical Journal2018，，5： | 15 |
| 2 | Stenting versus non-stenting treatment of intermediate stenosis culprit lesion in acute ST-segment elevation myocardial infarction: a multicenter random- ized clinical trial显示文摘在有单个容器中介狭窄犯人损害优点的心肌的梗塞(STEMI ) 病人进一步学习的尖锐圣片断举起的 stenting 的 BackgroundThe 利益 / 风险比率,因此现在的 study.Methods 和 resultsIt 的题目是一未来, multicenter,使随机化的控制试用。在 2012 年 4 月和 2015 年 7 月之间,有单个容器疾病和中介(40%-70%) 的 399 个尖锐 STEMI 病人在渴望 thrombectomy 或 intracoronary tirofiban 前后的犯人损害的狭窄(15 呍眠獡愠獳' 覒 X 整 ? 楷桴猠杩楮楦慣瑮椠灭潲敶敭瑮椠 ? ?癲癩污椠 ? 慰楴湥獴眠瑩 ?? | Jing DAI Shu-Zheng LYU Yun-Dai CHEN Xian-Tao SONG Min ZHANG Wei-Min LI Yang ZHENG Shang-Yu WEN Shao-Ping NIE Yu-Jie ZENG Hai GAO Yi-Tong MA Shu-Yang ZHANG Li-Jun GUO Zheng ZHANG | 2017 | Journal of Geriatric Cardiology2017，14，2： | 13 |
| 3 | First Imported Case of SARS-CoV-2 Omicron Subvariant BA.5—Shanghai Municipality,China,May 13,2022显示文摘On April 27,2022,an international flight KL857 from Amsterdam,the Netherlands arrived at Pudong International Airport,Shanghai Municipality.Passengers were transferred to the quarantine hotel for a routine 14-day medical observation in Songjiang District and regularly tested for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).One of the passengers(a 37-year-old Chinese male)was reported positive and diagnosed as a mild case on April 29.The case set out from Uganda(flight KL535)on April 25 and transferred at Amsterdam,the Netherlands on April 26 and Seoul,the Republic of Korea(KL857)on April 27.The patient has been vaccinated in four doses against coronavirus disease 2019(COVID-19)(Beijing Institute of Biological Products Co.,Ltd)in China and Uganda.After diagnosis,he was transferred to Shanghai Public Health Clinical Center for treatment.He recovered after treatment and was discharged on May 12. | Hui Jiang Changcheng Wu Wenbo Xu Hongyou Chen Fanghao Fang Min Chen Chaonan Wang Lingyue Yuan Huanyu Wu Zheng Teng Jinyuan Guo Yaxu Zheng Xihong Lyu Xuefei Qiao Guizhen Wu Wenjie Tan Xi Zhang | 2022 | China CDC weekly2022，4，30： | 10 |
| 4 | A two-step lineage reprogramming strategy to generate functionally competent human hepatocytes from fibroblasts显示文摘Terminally differentiated cells can be generated by lineage reprogramming,which is,however,hindered by incomplete conversion with residual initial cell identity and partial functionality. Here, we demonstrate a new reprogramming strategy by mimicking the natural regeneration route, which permits generating expandable hepatic progenitor cells and functionally competent human hepatocytes. Fibroblasts were first induced into human hepatic progenitor-like cells (hHPLCs), which could robustly expand in vitro and efficiently engraft in vivo. Moreover, hHPLCs could be efficiently induced into mature human hepatocytes (hiHeps) in vitro, whose molecular identity highly resembles primary human hepatocytes (PHHs). Most importantly, hiHeps could be generated in large quantity and were functionally competent to replace PHHs for drug-metabolism estimation, toxicity prediction and hepatitis B virus infection modeling. Our results highlight the advantages of the progenitor stage for successful lineage reprogramming. This strategy is promising for generating other mature human cell types by lineage reprogramming. | Bingqing Xie Da Sun Yuanyuan Du Jun Jia Shicheng Sun Jun Xu Yifang Liu Chengang Xiang Sitong Chen Huangfan Xie Qiming Wang Guangya Li Xuehui LYU Hui Shen Shiyu Li Min Wu Xiaonan Zhang Yue Pu Kuanhui Xiang Weifeng Lai Peng Du Zhenghong Yuan Cheng Li Yan Shi Shichun Lu Hongkui Deng | 2019 | Cell Research2019，29，9： | 9 |
| 5 | 禽腺病毒4型(FAdV-4)分离株对鸡的致病力及其基因组分析(英文)显示文摘目的:了解禽腺病毒4型(FAd V-4)分离株在口服、滴鼻点眼和肌注三种感染途径下对7~35日龄鸡的致病性,并分析该分离株与其他参考毒株在基因组水平上的差异。创新点:用原代鸡胚肾细胞(CEK)成功培养了FAd V-4分离株。发现除了常用的口服和肌注途径,FAd V-4也可通过滴鼻点眼接种途径感染7、21和35日龄鸡。肌注方法最为敏感,导致感染鸡100%死亡;35日龄鸡较7和21日龄鸡表现出更明显的临床症状和剖检病变。方法:通过口服、滴鼻点眼和肌注三种途径将FAd V-4分离株的CEK细胞培养物接种7~35日龄的无特定病原体(SPF)鸡。通过临床症状观察、排毒检测、病理解剖、免疫组化和组织中毒载量测定来判断分离株的致病性及病毒在组织脏器中的分布情况。通过病毒中和试验检测感染存活鸡的血清中和抗体。通过全基因组测序分析,比较FAd V-4分离株与国内外参考毒株的基因组序列差异。结论:本研究分离鉴定的FAd V-4分离株SD1511可以在CEK细胞上适应,并可以通过口服、滴鼻点眼和肌注三种感染途径引起7~35日龄的SPF鸡50%~100%的死亡,其中肌注最为敏感,死亡率达100%。感染鸡持续排毒至感染后的40天,产生具有明显中和作用的中和抗体。全基因组测序分析结果显示,SD1511基因组与最近国内分离的FAd V-4具有很高的同源性,但与国外的分离株有明显的差异。 | Kai-kun MO Chen-fei LYU Shang-shang CAO Xia LI Gang XING Yan YAN Xiao-juan ZHENG Min LIAO Ji-yong ZHOU | 2019 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2019，20，9： | 9 |
| 6 | Long-term outcomes of staged recanalization for concurrent chronic total occlusion in patients with ST-segment elevation myocardial infarction after primary percutaneous coronary intervention显示文摘Background In patients with acute ST-segment elevation myocardial infarction(STEMI)who undergo primary percutaneous coronary intervention(PCI),approximately 10%are concomitant with a chronic total occlusion(CTO)in a non-culprit vessel.However,the impact of staged CTO recanalization on prognosis in this cohort remains disputable.This study aimed to compare the long-term outcomes of staged CTO recanalization versus medical therapy in patients with STEMI after primary PCI.Methods Between January 2005 and December 2016,a total of 287 patients were treated with staged CTO-PCI(n=91)or medical therapy(n=196)after primary PCI in our center.The primary endpoint was major adverse cardiovascular and cerebrovascular event(MACCE),defined as a composite of all-cause death,nonfatal myocardial infarction(MI),stroke or unplanned revascularization.After propensity-score matching,77 pairs of well-balanced patients were identified.Results The mean follow-up period was 6.06 years.Overall,the incidence of the primary endpoint of MACCE was significantly lower in staged CTO-PCI group than that in medical therapy group in both overall population(22.0%vs.46.9%;hazard ratio(HR)=0.48,95%CI:0.29-0.77)and propensity-matched cohorts(22.1%vs.42.9%;HR:0.48,95%CI:0.27-0.86).In addition,staged CTO-PCI was also associated with reduced risk of the composite of cardiac death,nonfatal MI or stroke compared with medical therapy in both overall population(9.9%vs.26.5%;hazard ratio(HR)=0.39,95%CI:0.19-0.79)and propensity-matched cohorts(9.1%vs.22.1%;HR:0.40,95%CI:0.16-0.96).After correction of the possible confounders,staged CTO-PCI was independently associated with reduced risks of MACCE(adjusted HR:0.46,95%CI:0.28-0.75),the composite of cardiac death,nonfatal MI or stroke(adjusted HR:0.45,95%CI:0.22-0.94)and all-cause mortality(adjusted HR:0.32,95%CI:0.13-0.83).Moreover,the results of sensitivity analysis were almost concordant with the overall analysis.Conclusions In patients with STEMI and a concurrent CTO who undergo primary PCI,successful staged recanalization of CTO in the non-culprit vessels is associated with better clinical outcomes during long-term follow-up. | Kong-Yong CUI Fei YUAN Hong LIU Feng XU Min ZHANG Wei WANG Ming-Duo ZHANG Yun-Lu WANG Dong-Feng ZHANG Xiao ZHANG Jin-Fan TIAN Shu-Zheng LYU | 2020 | Journal of Geriatric Cardiology2020，17，1： | 8 |
| 7 | Spatial Variation of Dissolved Organic Carbon in Soils of Riparian Wetlands and Responses to Hydro-geomorphologic Changes in Sanjiang Plain, China显示文摘Spatial variation of dissolved organic carbon(DOC) in soils of riparian wetlands and responses to hydro-geomorphologic changes in the Sanjiang Plain were analyzed through in situ collecting soil samples in the Naoli River and the Bielahong River. The results showed that the average contents of DOC for soil layer of 0–100 cm were 730.6 mg/kg, 250.9 mg/kg, 423.0 mg/kg and 333.1 mg/kg respectively from riverbed to river terrace along the transverse directions of the Naoli watershed. The content of the soil DOC was the highest in the riverbed, lower in the high floodplain and much lower in the river terrace, and it was the lowest in the low floodplain. The difference in the content and vertical distribution of DOC between the riverbed and the three riparian wetlands was significant, while it was not significant among the low floodplain, the high floodplain and the river terrace. The variability of soil DOC was related to the hydrological connectivity between different landscape position of the riparian wetlands and the adjacent stream. Extremely significant correlations were observed between DOC and total organic carbon(TOC), total iron(TFe), ferrous iron(Fe(II)) whose correlation coefficients were 0.819, –0.544 and –0.709 in riparian wetlands of the Naoli River. With the increase of wetland destruction, soil p H increased and soil DOC content changed. The correlation coefficients between soil DOC and TOC, TFe, Fe(II) also changed into 0.759, –0.686 and –0.575 respectively in the Bielahong River. Under the impact of drainage ditches, the correlations between soil DOC and TFe, Fe(II) were not obvious, while the soil p H was weakly alkaline and was negatively correlated with soil DOC in the previous high floodplain. It indicates that riparian hydro-geomorphology is the main factor that could well explain this spatial variability of soil DOC, and the agricultural environmental hydraulic works like ditching also must be considered. | XI Min KONG Fanlong LYU Xianguo JIANG Ming LI Yue | 2015 | Chinese Geographical Science2015，25，2： | 7 |
| 8 | Prognostic performance of interleukin-10 in patients with chest pain and mild to moderate coronary artery lesions an 8-year follow-up study显示文摘BackgroundInterleukin (IL )-10, IL-6 和他们的比率(IL-6/IL-10 ) 在得冠的动脉疾病的风险起一个重要作用,并且可以与它的结果相关。很少临床的试用在与胸 pain.MethodsA 介绍的病人在长期的心血管的事件上调查了这些因素的预示的影响未来的学习在胸疼痛地招收并且识别的 566 个病人上被执行对中等冠的动脉损害温和。IL-10, IL-6 和 IL-6/IL-10 是完成的 511 个病人全部的 measured.ResultsA 后续。中部的后续时间是 74 个月。Kaplan-Meier 分析与 IL-10 的在中部下面的层次在病人在后续时期期间表明了主要不利心脏的事件的发生的清楚的增加(P = 0.006 ) 并且 IL-6/IL-10 的在中部上面的层次(P = 0.012 ) 。比例的危险分析显示了的穆尔蒂瓦里伊特·考克斯是在为内在的 confounders.ConclusionsElevated IL-10 层次的调整以后的强壮的独立预言者的 IL-10 层次胸疼痛地在病人与更有利的长期的预后被联系并且对中等冠的动脉损害温和。IL-10 能被用于对长期的预后的早风险评价。 | Dong-Feng ZHANG Xian-Tao SONG Yun-Dai CHEN Fei YUAN Feng XU Min ZHANG Ming-Duo ZHAN Wei WANG Jing DAI Shu-Zheng LYU | 2016 | Journal of Geriatric Cardiology2016，13，3： | 6 |
| 9 | Intratympanic dexamethasone injection for sudden sensorineural hearing loss in pregnancy显示文摘BACKGROUND As sudden sensorineural hearing loss(SSNHL)rarely occurs in pregnant women,there is a lack of knowledge and relevant research on its management.AIM To investigate the effect of intratympanic dexamethasone injection in the treatment of pregnant patients with SSNHL.METHODS A retrospective chart review was made for the period between June 2017 and August 2019 at our Department of Otorhinolaryngology-Head and Neck Surgery.Pregnant women who met the criteria for SSNHL were included and grouped based on the therapeutic modalities.The treatment group received intratympanic dexamethasone(2.5 mg)q.o.d.for a total of four times,while the control group received no medication other than bed rest and medical observations.All the patients were under close care of obstetricians.Pure-tone audiograms were performed before and after treatment.RESULTS Eleven patients who met the inclusion criteria were assigned to the treatment group(n=7)and the control group(n=4).The mean age of patients was 31.2±3.8 years;the right ear was affected in seven(63.64%)cases.Two patients(18.2%)suffered from vertigo,10(90.9%)suffered from tinnitus and 6(54.5%)suffered from aural fullness.The time from onset to clinic visit was relatively short,with a mean time of 1.3±0.9 d.All the women were within the second or third trimester;the average gestation period was 26.0±6.2 wk.The pure-tone averages at onset between the two groups were similar.After one wk of therapy,the treatment group had a curative rate of 57.1%and a significantly better hearing threshold and greater improvement compared to the control group(all P<0.05).Some patients experienced transient discomfort from intratympanic injections that disappeared after getting rest,while none had permanent complications.All patients delivered healthy full-term neonates with an average Apgar score of 9.7±0.5.CONCLUSION Intratympanic dexamethasone injections can be used as a first-line therapy in pregnant women with SSNHL. | Yan-Lu Lyu Fan-Qian Zeng Zhou Zhou Min Yan Wei Zhang Ming Liu Zhao-Yang Ke | 2020 | World Journal of Clinical Cases2020，8，18： | 4 |
| 10 | MATRIEX imaging:multiarea two-photon real-time in vivo explorer显示文摘Two-photon laser scanning microscopy has been extensively applied to study in vivo neuronal activity at cellular and subcellular resolutions in mammalian brains.However,the extent of such studies is typically confined to a single functional region of the brain.Here,we demonstrate a novel technique,termed the multiarea two-photon real-time in vivo explorer(MATRIEX),that allows the user to target multiple functional brain regions distributed within a zone of up to 12mm in diameter,each with a field of view(FOV)of ~200μm in diameter,thus performing two-photon Ca2+imaging with single-cell resolution in all of the regions simultaneously.For example,we demonstrate real-time functional imaging of single-neuron activities in the primary visual cortex,primary motor cortex and hippocampal CA1 region of mice in both anesthetized and awake states.A unique advantage of the MATRIEX technique is the configuration of multiple microscopic FOVs that are distributed in three-dimensional space over macroscopic distances(>1 mm)both laterally and axially but that are imaged by a single conventional laser scanning device.In particular,the MATRIEX technique can be effectively implemented as an add-on optical module for an existing conventional single-beam-scanning two-photon microscope without requiring any modification to the microscope itself.Thus,the MATRIEX technique can be readily applied to substantially facilitate the exploration of multiarea neuronal activity in vivo for studies of brain-wide neural circuit function with single-cell resolution. | Mengke Yang Zhenqiao Zhou Jianxiong Zhang Shanshan Jia Tong Li Jiangheng Guan Xiang Liao Bing Leng Jing Lyu Kuan Zhang Min Li Yan Gong Zhiming Zhu Junan Yan Yi Zhou Jian K Liu Zsuzsanna Varga Arthur Konnerth Yuguo Tang Jinsong Gao Xiaowei Chen Hongbo Jia | 2019 | Light(Science & Applications)2019，8，1： | 4 |
| 11 | Validation of the Simplified Chinese-character Version of the International Physical Activity Questionnaire-Long Form in Urban Community-dwelling Adults:a Cross-sectional Study in Hangzhou,China显示文摘Objective To assess the test-retest reliability and criterion validity of the Simplified Chinese-character version of the International Physical Activity Questionnaire Long form(IPAQ-L) in urban community-dwelling adults in Hanghzou,China.Methods A total of 158 eligible participants aged 25-59 years from 6 neighbourhoods in two central districts of Hangzhou completed the IPAQ-L questionnaire twice within a 7-day interval.Half of the subjects wore pedometers during the first 7 days.Test-retest reliability was examined by comparing the first(Day 1) and the second(Day 9) survey of IPAQ-L.Criterion validity was assessed by comparing IPAQ-L with pedometer data.Results Modest to good test-retest reliability was found with intraclass correlation coefficients of 0.67 for total PA,0.37 to 0.73 for specific dimensions,and 0.56 to 0.71 for different intensities of PA.Total PA measured by IPAQ-L was moderately correlated with exercise levels(partial r = 0.27,P = 0.020) and walking distance(partial r = 0.31,P = 0.007),which were measured by a pedometer,after adjusting for gender,age,educational attainment and employment status.Conclusion Our results indicate that the IPAQ-L is a reliable and validated measure for assessing physical activity levels in this population and possibly the adult population in other mainland Chinese cities. | REN Yan Jun SU Meng LIU Qing Min TAN Ya Yun DU Yu Kun LI Li Ming LYU Jun | 2017 | Biomedical and Environmental Sciences2017，30，4： | 4 |
| 12 | Diagnostic Utility of Diffusion-weighted Magnetic Resonance Imaging in Differentiating Small Solid Renal Tumors (≤4 cm) at 3.0T Magnetic Resonance Imaging显示文摘 | Han-Mei Zhang Ying-Hua Wu Qi Gan Xiao Lyu Xiang-Lan Zhu Min Kuang Rong-Bo Liu Zi-Xing Huang ang Yuan Xi-Jiao Liu Bin Song | 2015 | Chinese Medical Journal2015，，11： | 4 |
| 13 | Profiling and targeting of cellular mitochondrial bioenergetics: inhibition of human gastric cancer cell growth by carnosine显示文摘L-Carnosine (β-alanyl-L-histidine) is a naturally occurring dipeptide distributed in various organs of mammalians. We previously showed that carnosine inhibited proliferation of human gastric cancer cells through targeting both mitochondrial bioenergetics and glycolysis pathway. But the mechanism underlying carnosine action on mitochondrial bioenergetics of tumor cells remains unclear. In the current study we investigated the effect of carnosine on the growth of human gastric cancer SGC-7901 cells in vitro and in vivo. We firstly showed that hydrolysis of carnosine was not a prerequisite for its anti-gastric cancer effect. Treatment of SGC-7901 cells with carnosine (20?mmol/L) significantly decreased the activities of mitochondrial respiratory chain complexes I–IV and mitochondrial ATP production, and downregulated 13 proteins involved in mitochondrial bioenergetics. Furthermore, carnosine treatment significantly suppressed the phosphorylation of Akt, while inhibition of Akt activation with GSK690693 significantly reduced the localization of prohibitin-1 (PHB-1) in the mitochondria of SGC-7901 and BGC-823 cells. In addition, we showed that silencing of PHB-1 gene with shRNA markedly reduced the mitochondrial PHB-1 in SGC-7901 cells, and significantly decreased the colony formation capacity and growth rate of the cells. In SGC-7901 cell xenograft nude mice, administration of carnosine (250?mg?kg/d, ip, for 3 weeks) significantly inhibited the tumor growth and decreased the expression of mitochondrial PHB-1 in tumor tissue. Taken together, these results suggest that carnosine may act on multiple mitochondrial proteins to down-regulate mitochondrial bioenergetics and then to inhibit the growth and proliferation of SGC-7901 and BGC-823 cells. | Jiao-yan Cheng Jian-bo Yang Yuan Liu Min Xu Yu-yan Huang Jing-jing Zhang Pei Cao Jian-xin Lyu Yao Shen | 2019 | Acta Pharmacologica Sinica2019，40，7： | 4 |
| 14 | Spatial variations in CO2 fluxes in a subtropical coastal reservoir of Southeast China were related to urbanization and land-use types显示文摘Carbon dioxide(CO_(2))emissions from aquatic ecosystems are important components of the global carbon cycle,yet the CO_(2)emissions from coastal reservoirs,especially in developing countries where urbanization and rapid land use change occur,are still poorly understood.In this study,the spatiotemporal variations in CO_(2)concentrations and fluxes were investigated in Wenwusha Reservoir located in the southeast coast of China.Overall,the mean CO_(2)concentration and flux across the whole reservoir were 41.85±2.03μmol/L and 2.87±0.29 mmol/m2/h,respectively,and the reservoir was a consistent net CO_(2)source over the entire year.The land use types and urbanization levels in the reservoir catchment significantly affected the input of exogenous carbon towater.The mean CO_(2)fluxwasmuch higher from waters adjacent to the urban land(5.05±0.87 mmol/m2/hr)than other land use types.Sites with larger input of exogenous substance via sewage discharge and upstream runoff were often the hotspots of CO_(2)emission in the reservoir.Our results suggested that urbanization process,agricultural activities,and large input of exogenous carbon could result in large spatial heterogeneity of CO_(2)emissions and alter the CO_(2)biogeochemical cycling in coastal reservoirs.Further studies should characterize the diurnal variations,microbial mechanisms,and impact of meteorological conditions on reservoir CO_(2)emissions to expand our understanding of the carbon cycle in aquatic ecosystems. | Yifei Zhang Min Lyu Ping Yang Derrick Y.F.Lai Chuan Tong Guanghui Zhao Ling Li Yuhan Zhang Hong Yang | 2021 | Journal of Environmental Sciences2021，33，11： | 4 |
| 15 | Control over emissivity of zero-static-power thermal emitters based on phase-changing material GST显示文摘Controlling the emissivity of a thermal emitter has attracted growing interest,with a view toward a new generation of thermal emission devices.To date,all demonstrations have involved using sustained external electric or thermal consumption to maintain a desired emissivity.In the present study,we demonstrated control over the emissivity of a thermal emitter consisting of a film of phase-changing material Ge2Sb2Te5(GST)on top of a metal film.This thermal emitter achieves broad wavelength-selective spectral emissivity in the mid-infrared.The peak emissivity approaches the ideal blackbody maximum,and a maximum extinction ratio of 410 dB is attainable by switching the GST between the crystalline and amorphous phases.By controlling the intermediate phases,the emissivity can be continuously tuned.This switchable,tunable,wavelength-selective and thermally stable thermal emitter will pave the way toward the ultimate control of thermal emissivity in the field of fundamental science as well as for energy harvesting and thermal control applications,including thermophotovoltaics,light sources,infrared imaging and radiative coolers. | Kai-Kai Du Qiang Li Yan-Biao Lyu Ji-Chao Ding Yue Lu Zhi-Yuan Cheng Min Qiu | 2016 | Light(Science & Applications)2016，5，1： | 4 |
| 16 | Hybrid rice yield response to potted-seedling machine transplanting and slow-release nitrogen fertilizer application combined with urea topdressing显示文摘Machine transplanting and the application of slow-release nitrogen(N) fertilizer(SRNF) have played vital roles in the modernization of rice production. We aimed to determine the effects of potted-seedling transplanting—a new machine-transplanting method—and SRNF on hybrid rice yields. A 2-year splitplot experiment(2016–2017) was conducted in Meishan, Sichuan province, China, using two machinetransplanting methods(potted-seedling and blanket-seedling) and three N treatments. Total green leaf area, high-effective leaf area and its rate at heading, net photosynthetic rate of flag leaves 7 days after heading, glutamate synthase(GOGAT) and glutamine synthase(GS) activity after heading, dry matter production, and N accumulation at heading and maturity increased under the potted-seedling method or 70% SRNF as a base + 30% urea application at the panicle initiation stage(SBUP). Stem diameter and number of small and of all vascular bundles at the neck–panicle node in potted-seedling plants increased as a result of increasing numbers of effective panicles, secondary branches, and spikelets. In pottedseedling plants, treatment with SBUP increased the number of large and total vascular bundles at the panicle–neck internode and the number of differentiated and surviving secondary branches and spikelets and decreased the number of ineffective tillers and degenerated secondary branches and spikelets. We conclude that the potted-seedling machine transplanting method and SRNF combined with urea topdressing can strengthen the source–sink relationship in rice, resulting in higher yields. | Tengfei Lyu Jie Shen Jun Ma Peng Ma Zhiyuan Yang Zou Dai Chuangang Zheng Min Li | 2021 | The Crop Journal2021，9，4： | 3 |
| 17 | Influence of Acupuncture on Microcirculation Perfusion of Pericardium Meridian and Heart in Acute Myocardial Ischemia Model Rats显示文摘Objective: To observe the influence of acupuncture on microcirculation perfusion of the pericardium meridian and heart in acute myocardial ischemia(AMI) rats and evaluate whether acupuncture can simultaneously affect the meridians and corresponding viscera. Additionally, acupoints at different meridians were compared and whether they exert the same effects was discussed. Methods: Totally 32 Sprague-Dawley rats were subjected to left anterior descending(LAD) ligation to develop an AMI model.Rats were divided into 4 groups, including AMI, acupuncture Neiguan(PC 6), Lieque(LU 7) and Qiansanli(LI 10) groups(n=8). Eight rats received only thoracotomy(sham-operated group). The rats in the acupuncture groups received manual acupuncture at PC 6, LU 7 and LI 10 acupoints for 15 min, respectively. The microcirculation perfusion of pericardium meridian and heart was monitored by laser speckle perfusion imager(LSPI) before, during and after acupuncture manipulation for 15 min. Subsequently, the perfusion unit(PU)was calculated and analyzed by PSI System. Results: After LAD, compared to pre-acupuncture stage, the heart microcirculation perfusion(HMP) in the AMI group decreased continuously at during-acupuncture(P>0.05) and post-acupuncture stages(P<0.05), and the pericardium meridian microcirculation perfusion(PMP) showed no significant differences at 3 stages(P>0.05). Compared to pre-acupuncture stage, the PMP and HMP in PC 6 group significantly increased during acupuncture manipulation(both P<0.05), and PMP decreased obviously after acupuncture(P<0.05). The PMP in the LU 7 and LI 10 groups were slightly elevated(both P>0.05);however, they were significantly reduced after acupuncture manipulation(both P<0.05). Additionally, HMP of LI 10 group was decreased significantly during acupuncture, especially compared to pre-acupuncture stage(P<0.05). Conclusions: Acupuncture at PC 6 obviously increased the PMP and HMP in AMI rats, and the effects were superior to at LU 7 and LI 10 acupoints. It was further confirmed that acupuncture promoted qi and blood circulation, indicating that acupoint specificity exists and features a meridian-propagated effect. | ZHUANG Yi ZHOU Jie ZHOU Yu-mei CHEN Jiao WU Ping LYU Pei-ran WAN Min LUO Liao-jun CAI Ding-jun LIANG Fan-rong | 2022 | Chinese Journal of Integrative Medicine2022，28，1： | 3 |
| 18 | Evaluation of Xpert MTB/RIF for the Diagnosis of Extrapulmonary Tuberculosis in China显示文摘We evaluate the performance of Xpert MTB/RIF for the diagnosis of extrapulmonary tuberculosis(EPTB)in China.The performance of Xpert was evaluated compared to the composite reference standard(CRS),drug susceptibility testing(DST),and imaging examination.The overall sensitivity and specificity of Xpert were 64.1%(195/304)and 100%(24/24),respectively,using CRS as the gold standard.The sensitivity | YUAN Mei LYU Yan CHEN Su Ting CAi Chao LI Yuan ZHANG Zhi Guo LI Yun Xu DONG Ling Ling FU Yu Hong HUANG Hai Rong GAO Ji Min LI Wei Min | 2016 | Biomedical and Environmental Sciences2016，29，8： | 3 |
| 19 | Long term outcomes of drug-eluting stent versus coronary artery bypass grafting for left main coronary artery disease: a meta-analysis显示文摘BackgroundIt 仍然是争论的有 drug-eluting stent ( DES )的经皮的冠的干预是否与冠的动脉相比安全、有效为没有防卫的左主要冠的动脉( ULMCA )绕过接枝外科( CABG )疾病在长期列在后面在上面( 3 年) .MethodsEligible 研究被寻找 PubMed 选择, EMBASE ,并且 Cochrane 图书馆直到2016年12月6日。主要端点是一死亡,心肌的梗塞(MI ) 或在最长的后续期间的击合成。死亡,心脏的死亡, MI,击和重复 revascularization 是第二等的 outcomes.ResultsFour 使随机化的控制试用和包含 14,130 个病人的 12 调整观察研究被包括。DES 比得上关于主要端点的出现的 CABG (HR = 0.94, 95% CI:0.86-1.03 ) 。而且, DES 显著地与 MI 的更高的发生被联系(HR = 1.56, 95% CI:1.09-2.22 ) 并且重复 revascularization (HR = 3.09, 95% CI:2.33-4.10 ) 当没有差别在二策略之间被发现时,与 CABG 相比认为是死亡,心脏的死亡和击的率。而且, DES 能减少死亡, MI 或击的合成端点的风险(HR = 0.80, 95% CI:0.67-0.95 ) 因为有句法的 ULMCA 损害与重复 revascularization 的更高的风险获得 32 .ConclusionsAlthough,有 DES 的一种总线标准看起来象为 ULMCA 疾病在的 CABG 一样安全长期列在后面起来。另外,有 DES 的治疗能是到为 ULMCA 损害与的 CABG 的其他的 interventional 策略对中间的解剖复杂性低。 | Kong-Yong CUI Shu-Zheng LYU Xian-Tao SONG Fei YUAN Feng XU Min ZHANG Ming-Duo ZHANG Wei WANG Dong-Feng ZHANG Jing DAI Jin-Fan TIAN Yun-Lu WANG | 2018 | Journal of Geriatric Cardiology2018，15，2： | 3 |
| 20 | Extension Protocol for the Investigation on Nutrition Status and Clinical Outcome of Patients with Common Cancers in China(INSCOC)Study:2021 update显示文摘Background Malnutrition is common in patients with cancer,and this adversely affects the survival and quality of life of patients.Chinese Society for Nutritional Oncology issued a multi-center,large-scale,long-term follow-up prospective study,the Investigation on Nutrition Status and Clinical Outcome of Patients with Common Cancers in China(INSCOC study)since 2013.This is an extension to the previous 2013-2020 study protocol.This study still sought to:①address the prognostic impact of nutritional factors and quality of life on cancer patient survival;②describe the overall and cancer-specific incidence and/or distribution of malnutrition and different measurements of patient quality of life.Methods and study design This is an observational,multi-centered,hospital-based prospective cohort study.Data collection will be performed at baseline(within 48 hours after patient admission),during the hospital stay and 30 days after hospital admission.Follow-up will be conducted for 1-20 years after enrollment.The primary outcome will be the all-cause mortality/overall survival,and secondary outcomes will be the length of hospital stay and costs of hospitalization.Study factors will include demographic characteristics,tumor characteristics,information about chronic diseases,hematological measurements(e.g.,red blood cell count,total lymphocyte counts,hemoglobin,albumin,prealbumin,creatinine,C-reactive protein,IL-6),anthropometric measurements(e.g.,height,weight,arm circumference,arm muscle circumference,triceps skinfold thickness,and waist circumference),body composition parameters,PG-SGA scores,quality of life(as indicated by the QLQ-C30 questionnaire),muscle mass(as indicated by the calf circumference),muscle strength(as indicated by the handgrip strength),muscle function(as indicated by the six-meter walking speed test)and physical status assessments(as indicated by the Karnofsky Performance Status scores).This clinical study protocol was approved by local Ethics Committees of all the participating hospitals.Written informed consent is required for each subject included.Discussion This multi-center,large-scale,long-term follow up prospective study will help improve the diagnosis of malnutrition in cancer patients and identify the risk factors associated with adverse clinical outcomes.The anticipated results of this study will highlight the need for a truly scientific appraisal of nutrition therapy in Chinese oncology populations,and finally help treat the potentially reversible elements of malnutrition in cancer patients to improve their clinical outcomes in the future. | Hong Xia Xu Chun Hua Song Liang Yu Yin Chang Wang Zhen Ming Fu Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Fu Xiang Zhou Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Zhi Kang Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Xiang Hua Wu Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Min Weng Qing Hua Yao Ya Yin Yu Quan Jun Lyu Hong Qiu Ming Liu Wei Li Han Ping Shi The Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group | 2022 | Journal of Nutritional Oncology2022，7，2： | 3 |
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