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| 1 | Root microbiota shift in rice correlates with resident time in the field and developmental stage显示文摘Land plants in natural soil form intimate relationships with the diverse root bacterial microbiota. A growing body of evidence shows that these microbes are important for plant growth and health. Root microbiota composition has been widely studied in several model plants and crops; however, little is known about how root microbiota vary throughout the plant's life cycle under field conditions. We performed longitudinal dense sampling in field trials to track the time-series shift of the root microbiota from two representative rice cultivars in two separate locations in China. We found that the rice root microbiota varied dramatically during the vegetative stages and stabilized from the beginning of the reproductive stage, after which the root microbiota underwent relatively minor changes until rice ripening. Notably, both rice genotype and geographical location influenced the patterns of root microbiota shift that occurred during plant growth. The relative abundance of Deltaproteobacteria in roots significantly increased overtime throughout the entire life cycle of rice, while that of Betaproteobacteria, Firmicutes, and Gammaproteobacteria decreased. By a machine learning approach, we identified biomarker taxa and established a model to correlate root microbiota with rice resident time in the field(e.g., Nitrospira accumulated from 5 weeks/tillering in field-grown rice). Our work provides insights into the process of rice root microbiota establishment. | Jingying Zhang Na Zhang Yong-Xin Liu Xiaoning Zhang Bin Hu Yuan Qin Haoran Xu Hui Wang Xiaoxuan Guo Jingmei Qian Wei Wang Pengfan Zhang Tao Jin Chengcai Chu Yang Bai | 2018 | Science China(Life Sciences)2018，61，6： | 24 |
| 2 | A Review on Nano-Based Drug Delivery System for Cancer Chemoimmunotherapy显示文摘Although notable progress has been made on novel cancer treatments,the overall survival rate and therapeutic effects are still unsatisfactory for cancer patients.Chemoimmunotherapy,combining chemotherapeutics and immunotherapeutic drugs,has emerged as a promising approach for cancer treatment,with the advantages of cooperating two kinds of treatment mechanism,reducing the dosage of the drug and enhancing therapeutic effect.Moreover,nano-based drug delivery system(NDDS)was applied to encapsulate chemotherapeutic agents and exhibited outstanding properties such as targeted delivery,tumor microenvironment response and site-specific release.Several nanocarriers have been approved in clinical cancer chemotherapy and showed significant improvement in therapeutic efficiency compared with traditional formulations,such as liposomes(Doxil R,Lipusu R),nanoparticles(Abraxane R)and micelles(Genexol-PM R).The applications of NDDS to chemoimmunotherapy would be a powerful strategy for future cancer treatment,which could greatly enhance the therapeutic efficacy,reduce the side effects and optimize the clinical outcomes of cancer patients.Herein,the current approaches of cancer immunotherapy and chemoimmunotherapy were discussed,and recent advances of NDDS applied for chemoimmunotherapy were further reviewed. | Weiwei Mu Qihui Chu Yongjun Liu Na Zhang | 2020 | Nano-Micro Letters2020，12，10： | 8 |
| 3 | Repeatability and Reproducibility of Quantitative Assessment of the Retinal Microvasculature Using Optical Coherence Tomography Angiography Based on Optical Microangiography显示文摘Objective The aim of this study was to determine the repeatability and reproducibility of optical coherence tomography angiography(OCTA) based on optical microangiography(OMAG) measurements of macular vessels in normal eyes. Methods In this prospective cohort study, 40 eyes of 40 healthy volunteers underwent repeated OCTA(Cirrus HD-OCT 5000 angiography system, Carl Zeiss Meditec, Inc.) scans on two separate visit days. On each visit day, the eyes were scanned three times. The following parameters were used to quantitatively describe the OCTA images of the superficial vascular network: vessel area density(VAD), vessel skeleton density(VSD), vessel diameter index(VDI), vessel perimeter index(VPI), vessel complexity index(VCI), flux, and foveal avascular zone(FAZ). Coefficient of variation(CV) and intraclass correlation coefficient(ICC) were calculated for evaluating intravisit and intervisit repeatability, as well as interobserver reproducibility. Results The measurements showed high repeatability [CVs ≤ 4.2%(intravisit) and ≤ 4.6%(intervisit)] and interobserver reproducibility(ICCs ≥ 0.923) for all parameters. Conclusion This study demonstrated good repeatability and reproducibility of OCTA based on OMAG for the measurement of superficial vessel parameters in normal eyes. | ZHAO Qi YANG Wen Li WANG Xiao Na Ruikang K Wang YOU Qi Sheng CHU Zhong Di XIN Chen ZHANG Meng Yu LI Dong Jun WANG Zi Yang CHEN Wei LI Yi Feng CUI Rui SHEN Lin WEI Wen Bin | 2018 | Biomedical and Environmental Sciences2018，31，6： | 8 |
| 4 | Relationship between Sleep Quality and Cognitive Function in Patients with Mild-to-Moderate Parkinson's Disease显示文摘 | Hui-Miao Liu Miao Chu Na Li Sai Zhang Yong-Zhi Zhang Ping Gu | 2018 | Chinese Medical Journal2018，，8： | 6 |
| 5 | Danggui Buxue Tang ameliorates bleomycin-induced pulmonary fibrosis in rats through inhibiting transforming growth factor-β1/Smad3/plasminogen activator inhibitor-1 signaling pathway显示文摘OBJECTIVE: To investigate the effect of Danggui Buxue Tang(DBT), a decoction from Traditional Chinese Medicine, on bleomycin-induced pulmonary fibrosis in rats, and to propose the possible underlying mechanism.METHODS: Forty male Sprague-Dawley rats were randomly divided into sham group, model group,prednisone group and DBT group. Pulmonary fibrosis rat model was established by intratracheal injection with bleomycin. Body weight and lung index were monitored. Histopathologic examination and collagen deposition were determined using Hematoxylin and eosin(HE) and Masson's trichrome staining. Immunohistochemistry staining was applied to observe the expression of alpha-smooth muscle actin(α-SMA). m RNA expression of α-SMA,collagen Ⅰ and collagen Ⅲ were measured by realtime fluorescence quantitative PCR(RT-q PCR). Inflammatory cytokines, including tumor necrosis factor alpha(TNF-α), interleukin-6(IL-6) and IL-1β in serum were detected by Enzyme-linked immunosorbent assay. Alkali hydrolysis method was conducted to investigate the content of hydroxyproline(HYP). Transforming growth factor-β1(TGF-β1),Smad3 and plasminogen activator inhibitor-1(PAI-1) protein level were examined by Western blot assay.RESULTS: DBT significantly reduced the severity of bleomycin-induced pulmonary fibrosis and inflammation as indicated by minimizing the lost of weight, and by lowering the levels of lung index, inflammation score, Ashcroft score, collagen volume fraction(%), HYP, α-SMA, collagen Ⅰ, collagen Ⅲ,TNF-α, IL-6, IL-1β, TGF-β1, Smad3 and PAI-1, consistent with the effect of prednisone.CONCLUSION: Our findings suggest that DBT is able to ameliorate the pulmonary fibrosis, the possible mechanism may involve inhibition of pulmonary inflammation and collagen deposition, possibly via suppressing TGF-β1/Smad3/PAI-1 signaling pathway. | Wang Jiepeng Fang Chaoyi Wang Shaoxian Fang Fang Chu Xinqiao Liu Na Lu Chenxi Wang Shuo Li Wei | 2020 | Journal of Traditional Chinese Medicine2020，40，2： | 5 |
| 6 | Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma显示文摘Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer(NSCLC)risk,biological mechanisms of these variants remain largely unknown.By integrating a large-scale genotype data of 15581 lung adenocarcinoma(AD)cases,8350 squamous cell carcinoma(SqCC)cases,and 27355 controls,as well as multiple transcriptome and epigenomic databases,we conducted histology-specific meta-analyses and functional annotations of both reported and novel susceptibility variants.We identified 3064 credible risk variants for NSCLC,which were overrepresented in enhancer-like and promoter-like histone modification peaks as well as DNase I hypersensitive sites.Transcription factor enrichment analysis revealed that USF1 was AD-specific while CREB1 was SqCC-specific.Functional annotation and genebased analysis implicated 894 target genes,including 274 specifics for AD and 123 for SqCC,which were overrepresented in somatic driver genes(ER=1.95,P=0.005).Pathway enrichment analysis and Gene-Set Enrichment Analysis revealed that AD genes were primarily involved in immune-related pathways,while SqCC genes were homologous recombination deficiency related.Our results illustrate the molecular basis of both wellstudied and new susceptibility loci of NSCLC,providing not only novel insights into the genetic heterogeneity between AD and SqCC but also a set of plausible gene targets for post-GWAS functional experiments. | Na Qin Yuancheng Li Cheng Wang Meng Zhu Juncheng Dai Tongtong Hong Demetrius Albanes Stephen Lam Adonina Tardon Chu Chen Gary Goodman Stig EBojesen Maria Teresa Landi Mattias Johansson Angela Risch H-Erich Wichmann Heike Bickeboller Gadi Rennert Susanne Arnold Paul Brennan John KField Sanjay Shete Loic Le Marchand Olle Melander Hans Brunnstrom Geoffrey Liu Rayjean JHung Angeline Andrew Lambertus AKiemeney Shan Zienolddiny Kjell Grankvist Mikael Johansson Neil Caporaso Penella Woll Philip Lazarus Matthew BSchabath Melinda CAldrich Victoria LStevens Guangfu Jin David CChristiani Zhibin Hu Christopher IAmos Hongxia Ma Hongbing Shen | 2021 | Frontiers of Medicine2021，15，2： | 3 |
| 7 | Early outcomes of vision and objective visual quality analysis after cataract surgery with trifocal intraocular lens implantation显示文摘AIM: To investigate the early outcomes of vision, objective visual quality and their correlation after cataract surgery with trifocal intraocular lens implantation.METHODS: The visual examination and objective visual quality analysis using Optical Quality Analysis System(OQAS) at 1 mo and 3 mo, and defocus curve examination at 3 mo were performed in 20 patients(27 eyes) after phacoemulsification combined with trifocal intraocular lens implantation surgery.RESULTS: The uncorrected distant(UD), intermediate and near visual acuity(VA) were significantly improved after surgery(P<0.001). UDVA at 1 mo after the surgery was slightly better than that after 3 mo(P=0.026). The defocus curve after 3 mo indicated that the peak of distant vision was close to 0 logMAR, and UDVA was lower than 0.3 logMAR in the range of-1.5 D to-3.0 D. The modulation transfer function(MTF) cutoff frequency, strehl ratio(SR), Optical Quality Analysis System values(OVs), includes OV100, OV20 and OV9 after the surgery were significantly better than before surgery(P<0.001), but the objective scattering index(OSI) was significantly decreased(P<0.001). UDVA at 3 mo after the surgery had correlations with MTF cutoff, OSI, OV100 and OV20(r=-0.400, 0.431,-0.437,-0.411, P=0.039, 0.025, 0.023, 0.033). The uncorrected intermediate VA after 3 mo of the surgery had correlations with OSI and OV100(r=0.478,-0.411, P=0.012, 0.033). CONCLUSION: Trifocal intraocular lens implantation can provide good distant, intermediate and near VA, and the vision shows a well correlation with objective visual quality during early surgery. | Mei-Fang Chu Na Hui Cong-Yi Wang Lei Yu Bo Ma Yan Li Cheng Pei | 2019 | International Journal of Ophthalmology(English edition)2019，12，10： | 3 |
| 8 | Ground-based Observations of Ultraviolet and Total Solar Radiation in Shenyang,Northeast China显示文摘Objective This work explores the diurnal variation of Solar ultraviolet radiation (UVR) and total solar radiation (TSR) in northeast China,using daily observations of UVR and TSR in Shenyang.Methods UVR and TSR measurements were carried out from March 1st,2006 to December 31st,2009 in Shenyang,Liaoning province,China (41°51' N,123°27' E).Results Both TSR and UVR showed seasonal variation,reaching the highest levels in summer and the lowest in winter.They showed the greatest fluctuation in summer and autumn.The irradiance of TSR and UVR on clear days around the equinoxes and solstices increased substantially compared with the mean seasonal irradiance,especially in autumn.The whole day accumulated dose of UVR in winter was far less than that during the middle part of a summer day (i.e.between 10:00 and 14:00).It was also less than the accumulated summer dose of morning and afternoon (i.e.between 8:00 and 10:00 and 14:00 and 16:00).Conclusion The instant irradiance and daily accumulated amount of UVR are low in Shenyang,especially in autumn and winter.Thus concern about the health effects arising because shortage of UVR in northeast China is warranted. | GAO Qian HU LiWen GONG HuiZhi GAO Na YU JiaMing WANG Yang CHU Chun YANG Hui LIU Yang | 2011 | Biomedical and Environmental Sciences2011，24，5： | 2 |
| 9 | 电磁监测试验卫星及其初步成果显示文摘As the first satellite of the China national geophysical field observation series of stllite missions,the China Seismo--Electromagnetic Satellite(CSES)was designed upon an optimized CAST2000 platform for a sun synchronous orbit.Onboard CSES,there are total eight types of scientific payloads including the Search-coil Magnetometer,Electric Field Detector,High Precision Magnetometer,GNSS Occupation Receiver,Plasma Analyzer,Langmuir Probe,Energetic Particle Detector Package,and a Three-band Transmitter to individually acquire the global eletromagnetic field,elec-tromagnetic waves,ionospheric plasma parameters as well as energetic particles.Up to now,CSES has been operating normally in orbit for 2 years.By using the various sensor data acquired by CSES,we have achieved scientfic research in the areas of the global geomagnetic field modeling,space weather,earthquake event analysis,the Lithosphere-Atmo-sphere-lonosphere coupling mechanism and so on.. | SHEN Xuhui ZEREN Zhima YUAN Shigeng DAI Jianping HUANG Jianping ZHU Xinghong YANG Yanyan YAN Rui ZHAO Shufan LIU Dapeng ZHANG Zhenxia WANG Qiao CHU Wei LU Hengxin XU Song GUO Feng TAN Qiao LI Wenjing ZHOU Na | 2020 | Aerospace China2020，21，1： | 2 |
| 10 | Spectral Preprocessing Combined with Deep Transfer Learning to Evaluate Chlorophyll Content in Cotton Leaves显示文摘Rapid determination of chlorophyll content is significant for evaluating cotton’s nutritional and physiological status.Hyperspectral technology equipped with multivariate analysis methods has been widely used for chlorophyll content detection.However,the model developed on one batch or variety cannot produce the same effect for another due to variations,such as samples and measurement conditions. | Qinlin Xiao Wentan Tang Chu Zhang Lei Zhou Lei Feng Jianxun Shen Tianying Yan Pan Gao Yong He Na Wu | 2022 | Plant Phenomics2022，4，1： | 2 |
| 11 | The PSCA polymorphisms derived from genome-wide association study are associated with risk of gastric cancer: a meta-analysis显示文摘 | Danni Shi Shizhi Wang Dongying Gu Dongmei Wu Meilin Wang Haiyan Chu Na Tong Lan Ma Dongyan Zhong Zhengdong Zhang | 2012 | Journal of Cancer Research and Clinical Oncology2012，，8： | 2 |
| 12 | Bioactive hyaluronic acid fragments inhibit lipopolysaccharideinduced inflammatory responses via the Toll-like receptor 4 signaling pathway显示文摘The high-and the low-molecular weight hyaluronic acids(HMW-HA and LMW-HA,respectively)showed different biological activities in inflammation.However,the role of LMW-HA in inflammatory response is controversial.In this study,we aimed to investigate the effect of bioactive hyaluronan(B-HA)on lipopolysaccharide(LPS)-induced inflammatory responses in human macrophages and mice.B-HA was produced from HA treated with glycosylated recombinant human hyaluronidase PH20.Human THP-1 cells were induced to differentiate into macrophages.THP-1-derived macrophages were treated with B-HA,LPS,or B-HA+LPS.The mRNA expression and the production of inflammatory cytokines were determined using quantitative real-time PCR and enzyme-linked immunosorbent assay.The phosphorylation levels of proteins in the nuclear factor-kB(NF-kB),mitogen-activated protein kinase(MAPK),and IRF-3 signaling pathways were measured using Western blot.The in vivo efficacy of B-HA was assessed in a mouse model of LPS-induced inflammation.Results showed that B-HA inhibited the expression of TNF-α,IL-6,IL-1,and IFN-β,and enhanced the expression of the antiinflammatory cytokine IL-10 in LPS-induced inflammatory responses in THP-1-derived macrophages and in vivo.B-HA significantly suppressed the phosphorylation of the TLR4 signaling pathway proteins p65,IKKα/β,IkBα,JNK1/2,ERK1/2,p38,and IRF-3.In conclusion,our results demonstrated that the B-HA attenuated the LPSstimulated inflammatory response by inhibiting the activation of the TLR4 signaling pathway.B-HA could be a potential anti-inflammatory drug in the treatment of inflammatory disease. | Na You Sasa Chu Binggang Cai Youfang Gao Mizhou Hui Jin Zhu Maorong Wang | 2021 | Frontiers of Medicine2021，15，2： | 2 |
| 13 | Lymphangioleiomyomatosis:abdominopelvic CT and US findings显示文摘 | Avila NA Kelly JA Chu SC | 2000 | Radiology2000，216，： | 1 |
| 14 | Pulmonary lymphangioleiomyomatosis: correlation of ventilation-perfusion scintigraphy, chest radiography, and CT with pulmonary function tests 显示文摘 | Avila NA Chen CC Chu SC | 2000 | Radiology2000，214，2： | 1 |
| 15 | Heavy metals in coastal wetland sediments of the Pearl River Estuary, China显示文摘 | QuSheng Li ZhiFeng Wu Bei Chu Na Zhang ShaSha Cai JianHong Fang | 2007 | Environmental Pollution2007，，2： | 1 |
| 16 | Pixel-level image fusion based onmulti-to-multi turbo iterative显示文摘 | Li Na He Chu Yu Lei | 2007 | IEEE2007，7，2： | 1 |
| 17 | Lymphangioleiomyomatosis: abdominopelvic CT and US findings 显示文摘 | Avila NA Kelly JA Chu SC | 2000 | Radiology2000，216，1： | 1 |
| 18 | Determination of IPMP and IBMP in water with liquid-liquid extraction-gas chromatography-mass spectrometry显示文摘 | AN Na GAO Nai-yun CHU Wen-hai XIE Hui-hui | 2011 | Jounal of Tongji University2011，39，8： | 1 |
| 19 | Genome-wide analysis of long noncoding RNA signature in human colorectal cancer显示文摘 | Yao Xue Gaoxiang Ma Dongying Gu Lingjun Zhu Qiuhan Hua Mulong Du Haiyan Chu Na Tong Jinfei Chen Zhengdong Zhang Meilin Wang | 2014 | Gene2014，，： | 1 |
| 20 | 街区可步行性和交通相关空气污染的交互作用对高血压和糖尿病的影响显示文摘居住于不宜步行的街区已被认为与糖尿病和高血压的高风险相关。然而,高度可步行的环境可能存在更高浓度的交通相关污染,可能会增加心血管病风险。该文旨在评估可步行性和交通相关污染如何联合影响高血压和糖尿病风险。方法:研究者2008年1月1日从行政数据库中挑选了一组基于人群的交叉横断面样本,样本为年龄40~74岁居住于加拿大安大略省的一些选择性大型城市中心的个体。 | 袁源(译) 叶鹏(校) Howell NA Tu JV Moineddin R Chen H Chu A Hystad P Booth GL | 2020 | 中华高血压杂志2020，28，8： | 1 |
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