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| 1 | Diverse modes of clonal evolution in HBV-related hepatocellular carcinoma revealed by single-cell genome sequencing显示文摘Hepatocellular 癌(HCC ) 是癌症实质词法,基因并且 phenotypic 差异。然而,我们不理解在 intratumor 异质和肿瘤的联系词法 / 组织学的特征之间的关系。用介绍 96 个肿瘤房间(30-36 各个) 和 15 个正常的肝房间(5 各个) 的单个房间的整个染色体的定序,与联系 HBV 的 HCC 从三个男病人收集了,我们证实拷贝数字变化在 hepatocarcinogenesis 早发生,但是此后在整个肿瘤仍然保持相对稳定前进。重要地,我们证明特定的 HCC 能具有 monoclonal 或 polyclonal 起源。有汇合的 multinodular 形态学的肿瘤是典型 polyclonal 肿瘤并且显示最高的 intratumor 异质。除了 mutational 和拷贝数字侧面,我们把了用导出 HBV 的外国 genomic 标记的 HCC 的同种细胞的起源。在 monoclonal HCC,所有肿瘤单身者房间展出一样的 HBV 集成,显示 HBV 集成是一个早司机事件并且在肿瘤前进期间仍然保持极其稳定。另外,我们的结果显示那两个都转移,迟了的传播并且早播种当模特儿,在 HCC 有一个角色前进。尤其是,开始的克隆传播的早 intrahepatic 导致同步 multifocal 肿瘤的形成。同时,我们在 HCC 识别了潜在的司机基因 ZNF717,它展出变化的高频率在单个房间并且人口铺平,,通过调整 IL-6/STAT3 小径行动的肿瘤 suppressor。这些调查结果热点多重不同肿瘤在 HCC 的进化机制,它为特定的处理策略建议需要。 | Meng Duan, Shu Zhang, Zhichao Wang, Jieyi Shi, Longzi Liu, Xiaoying Wang, Aiwu Ke, Jian Zhou, Jia Fan, Qiang Gao Junfeng Hao, Chong Li Sijia Cui Daniel L Worthley Ya Cao Ruibin Xi Xiaoming Zhang Jian Zhou, Jia Fan Qiang Gao | 2018 | Cell Research2018，28，3： | 21 |
| 2 | Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC)is a poor-prognosis cancer type with limited understanding of its molecular etiology.Using 508 ESCC genomes,we identified five novel significantly mutated genes and uncovered mutational signature clusters associated with metastasis and patients’outcomes.Several functional assays implicated that NFE2L2 may act as a tumor suppressor in ESCC and that mutations in NFE2L2 probably impaired its tumor-suppressive function,or even conferred oncogenic activities.Additionally,we found that the NFE2L2 mutations were significantly associated with worse prognosis of ESCC.We also identified potential noncoding driver mutations including hotspot mutations in the promoter region of SLC35E2 that were correlated with worse survival.Approximately 5.9%and 15.2%of patients had high tumor mutation burden or actionable mutations,respectively,and may benefit from immunotherapy or targeted therapies.We found clinically relevant coding and noncoding genomic alterations and revealed three major subtypes that robustly predicted patients’outcomes.Collectively,we report the largest dataset of genomic profiling of ESCC useful for developing ESCC-specific biomarkers for diagnosis and treatment. | Yongping Cui Hongyan Chen Ruibin Xi Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qimin Zhan Yanhong Li Zhihua Liu-Show | 2020 | Cell Research2020，30，10： | 19 |
| 3 | A User Differential Range Error Calculating Algorithm Based on Analytic Method显示文摘提高完整,有更少的执行时间的一个分析方法(AM ) 被建议计算微分范围错误(UDRE ) 由用户过去常检测潜在的风险的用户。位置推算历和钟修正计算方法首先被介绍。它证明计算 UDRE 的最重要的事情是在服务体积发现最糟的用户地点(WUL ) 。然后,用 AM 的一个 UDRE 算法被描述解决这个问题。由使用错误向量的协变性矩阵,寻找 WUL 被变换成一个分析几何学问题。WUL 的地点能被数学推导直接获得。实验被进行比较在建议 AM 算法和在主人车站使用的彻底的格子搜索(EGS ) 方法之间的表演。AM 算法的正确性能被 EGS 方法和 AM 算法证明的结果表演能在超过 90% 减少计算时间。这个建议算法的计算复杂性从而比 EGS. 的好这个算法对在主人车站计算 UDRE 更合适。 | SHAO Bo LIU Jiansheng ZHAO Ruibin HUANG Zhigang LI Rui | 2011 | Chinese Journal of Aeronautics2011，24，6： | 7 |
| 4 | Study of latch-up immunization in bulk CMOS integrated circuits exposed to transient ionizing radiation显示文摘This paper presents experimental results of transient gamma irradiation effects on two kinds of circuits.One is a two-stage circuit consisting of a bipolar power device L7805CV and a bulk complementary metal-oxide-semiconductor(CMOS) device IDT6116,the other is a two-stage circuit consisting of a bipolar power device L7805CV and the equivalent circuit of the parasitic P-N-P-N structure in bulk CMOS devices.The results show that the L7805CV's output interruption after transient irradiation can prevent latch-up from occurring on the second stage circuit.The demanded minimum interruption duration to avoid latch-up varies with dose rate,and this is confirmed by the experimental results. | LI RuiBin CHEN Wei LIN DongSheng YANG ShanChao BAI XiaoYan WANG GuiZhen LIU Yan QI Chao MA Qiang | 2012 | Science China(Technological Sciences)2012，55，11： | 5 |
| 5 | North Pacific Eastern Subtropical Mode Water simulation and future projection显示文摘The present climate simulation and future projection of the Eastern Subtropical Mode Water(ESTMW) in the North Pacific are investigated based on the Geophysical Fluid Dynamics Laboratory Earth System Model(GFDL-ESM2M). Spatial patterns of the mixed layer depth(MLD) in the eastern subtropical North Pacific and the ESTMW are well simulated using this model. Compared with historical simulation, the ESTMW is produced at lighter isopycnal surfaces and its total volume is decreased in the RCP8.5 runs, because the subduction rate of the ESTMW decreases by 0.82×10-6 m/s during February–March. In addition, it is found that the lateral induction decreasing is approximately four times more than the Ekman pumping, and thus it plays a dominant role in the decreased subduction rate associated with global warming. Moreover, the MLD during February–March is banded shoaling in response to global warming, extending northeastward from the east of the Hawaii Islands(20°N, 155°W) to the west coast of North America(30°N, 125°W), with a maximum shoaling of 50 m, and then leads to the lateral induction reduction. Meanwhile, the increased northeastward surface warm current to the east of Hawaii helps strengthen of the local upper ocean stratification and induces the banded shoaling MLD under warmer climate. This new finding indicates that the ocean surface currents play an important role in the response of the MLD and the ESTMW to global warming. | XIA Ruibin LIU Qinyu XU Lixiao LU Yiqun | 2015 | Acta Oceanologica Sinica2015，34，3： | 5 |
| 6 | Highly luminescent and stable lead-free cesium copper halide perovskite powders for UV-pumped phosphor-converted light-emitting diodes显示文摘Lead halide perovskites have drawn extensive attention over recent decades owing to their outstanding photo-electric performances.However,their toxicity and instability are big issues that need to be solved for further commercialization.Herein,we adopt a facile dry ball milling method to synthesize lead-free Cs3Cu2X5(X=I,CI)perovskites with photoluminescence(PL)quantum yield up to 60%.The optical features including broad emission spectrum,large Stokes shift,and long PL lifetime can be attributed to self-trapped exciton recombination.The as-synthesized blue emissive Cs3Cu2I5 and green emissive Cs3Cu2Cl5 lead-free perovskite powders have good thermal stability and photostability.Furthermore,UV-pumped phosphor-converted light-emitting diodes were obtained by using Cs3Cu2I5 and Cs3Cu2Cl5 as phosphors. | LINGLING XIE BINGKUN CHEN FA ZHANG ZHENG ZHAO XINXIN WANG LIJIE SHI YUE LIU LINGLING HUANG RUIBIN LIU BINGSUO ZOU YONGTIAN WANG | 2020 | Photonics Research2020，8，6： | 5 |
| 7 | On the Response of Subduction in the South Pacific to an Intensification of Westerlies and Heat Flux in an Eddy Permitting Ocean Model显示文摘Based on an eddy permitting ocean general circulation model, the response of water masses to two distinct climate scenarios in the South Pacific is assessed in this paper. Under annually repeating atmospheric forcing that is characterized by different westerlies and associated heat flux, the response of Subantarctic Mode Water(SAMW) and Antarctic Intermediate Water(AAIW) is quantitatively estimated. Both SAMW and AAIW are found to be warmer, saltier and denser under intensified westerlies and increased heat loss. The increase in the subduction volume of SAMW and AAIW is about 19.8 Sv(1 Sv =10~6m^3s^(-1)). The lateral induction term plays a dominant role in the changes in the subduction volume due to the deepening of the mixed layer depth(MLD). Furthermore, analysis of the buoyancy budget is used to quantitatively diagnose the reason for the changes in the MLD. The deepening of the MLD is found to be primarily caused by the strengthening of heat loss from the ocean to the atmosphere in the formation region of SAMW and AAIW. | Chengyan LIU Zhaomin WANG Bingrui LI Chen CHENG Ruibin XIA | 2017 | Advances in Atmospheric Sciences2017，34，4： | 5 |
| 8 | On the subtropical Northeast Pacific mixed layer depth and its influence on the subduction显示文摘The present climate simulations of the mixed layer depth(MLD) and the subduction rate in the subtropical Northeast Pacific are investigated based on nine of the CMIP5 models. Compared with the observation data,spatial patterns of the MLD and the subduction rate are well simulated in these models. The spatial pattern of the MLD is nonuniform, with a local maximum MLD(>140 m) region centered at(28°N, 135°W) in late winter. The nonuniform MLD pattern causes a strong MLD front on the south of the MLD maximum region, controls the lateral induction rate pattern, and then decides the nonuniform distribution of the subduction rate. Due to the inter-regional difference of the MLD, we divide this area into two regions. The relatively uniform Ekman pumping has little effect on the nonuniform subduction spatial pattern, though it is nearly equal to the lateral induction in values. In the south region, the northward warm Ekman advection(–1.75×10^(–7) K/s) controls the ocean horizontal temperature advection(–0.85×10^(–7) K/s), and prevents the deepening of the MLD. In the ensemble mean, the contribution of the ocean advection to the MLD is about –29.0 m/month, offsetting the sea surface net heat flux contribution(33.9 m/month). While in the north region, the southward cold advection deepens the MLD(21.4 m/month) as similar as the heat flux(30.4 m/month). In conclusion, the nonuniform MLD pattern is dominated by the nonuniform ocean horizontal temperature advection. This new finding indicates that the upper ocean current play an important role in the variability of the winter MLD and the subduction rate. | XIA Ruibin LIU Chengyan CHENG Chen | 2018 | Acta Oceanologica Sinica2018，37，3： | 4 |
| 9 | Comparative transcriptome study provides insights into acquisition of embryogenic ability in upland cotton during somatic embryogenesis显示文摘Background: The conversion from non-embryogenic callus(NEC) to embryogenic callus(EC) is the key bottleneck step in regeneration of upland cotton(Gossypium hirsutum), and hinders the transgenic breeding of upland cotton.To investigate molecular mechanisms underlying acquisition of embryogenic potential during this process, comparation analysis of transcriptome dynamics between two upland cotton cultivars with different somatic embryogenesis abilities was conducted.Results: Differentially expressed genes involved in the transformation from NEC to EC were detected in the two different cultivars. Principal component analysis based on DEGs showed that the NEC tissues of the two cultivars were highly heterogeneous, whereas the derived EC tissues were similar, which suggested the homogeneousness of EC between different lines. In the highly embryogenic cultivar CCRI 24, more of these genes were down-regulated, whereas,in the recalcitrant cultivar CCRI 12, more were up-regulated. Bioinformatics analysis on these DEGs showed that the vast majority of differentially expressed genes were enriched in metabolism and secondary metabolites biosynthesis pathways. Flavonoid biosynthesis and phenylpropanoid biosynthesis pathways were enriched in both cultivars,and the associated genes were down-regulated more in CCRI 24 than in CCRI 12. We deduced that vigorous secondary metabolism in CCRI 12 may hinder primary metabolism, resulting in tardiness of cell differentiation.Interestingly, genes involved in the plant hormone signal transduction pathway were enriched in the recalcitrant cultivar CCRI 12 but not in CCRI 24, suggesting more radical regulation of hormone signal transduction in the recalcitrant cultivar. Signal transduction rather than biosynthesis of plant hormones is more likely to be the determining factor triggering NEC to EC transition in recalcitrant cotton lines. Transcription factor encoding genes showed differential regulation between two cultivars.Conclusions: Our study provides valuable information about the molecular mechanism of conversion from NEC to EC in cotton and allows for identification of novel genes involved. By comparing transcriptome changes in transformation from NEC to EC between the two cultivars, we identified 46 transcripts that may contribute to initiating embryogenic shift. | SUN Ruibin TIAN Ruiping MA Dan WANG Shaohui LIU Chuanliang | 2018 | Journal of Cotton Research2018，1，2： | 3 |
| 10 | Robot Intelligence for Real World Applications显示文摘This paper presents a brief review on recent work on machine intelligence for real-world applications of robots.To act in a real world environment,a robot should possess a broad sense of intelligence including speech,perception,reasoning,action,etc.In this paper,we particularly deal with the intelligence involving action or body motion.The intelligence related to robot action/motion can be classified into two categories:manipulation intelligence and mobility intelligence.The manipulation intelligence means the skill/intelligence of reliably manipulating objects according to tasks and the mobility intelligence corresponds to the ability of autonomously moving,or flying,and or jumping in a natural environment.Human-robot interaction is another important topic for real-world applications.In addition to reviewing the ma jor approaches,this paper also gives an overview on our efforts in these important topics. | LIU Yunhui ZHENG Fan GUO Ruibin WANG Jiangliu NIE Qiang WANG Xin WANG Zerui | 2018 | Chinese Journal of Electronics2018，27，3： | 3 |
| 11 | The outbreak of rabbit hemorrhagic virus type 2 in the interior of China may be related to imported semen显示文摘Dear Editor,Rabbit hemorrhagic disease(RHD)is a fatal infectious disease that primarily affects adult rabbits and causes great economic losses in the rabbit industry(Mitro and Krauss,1993).The causative pathogen is rabbit hemorrhagic disease virus(RHDV),which belongs to the genus Lagovirus and the family Calicivirus(Moussa et al.,1992).In 1984,RHDV was first documented in China. | Ruibin Qi Chunchun Meng Jie Zhu Hang Li Qiuhong Miao Jingyu Tang Aoxing Tang Hongyuan Guo Chuncao Liu Chuanfeng Li Zongyan Chen Fang Wang Qinwen Zhang Guangqing Liu | 2022 | Virologica Sinica2022，37，4： | 3 |
| 12 | 2021 Chinese consensus on the diagnosis and management of primary immune thrombocytopenia in pregnancy显示文摘Immune thrombocytopenia(ITP)is an acquired disease characterized by isolated thrombocytopenia,which is one of the most common causes of thrombocytopenia during pregnancy.Women with ITP who have severe thrombocytopenia are at an increased risk for life-threatening obstetric complications.Therefore,we established this consensus statement on the diagnosis and management of ITP during pregnancy(detailed information is available in the Supplementary File,http://links.lww.com7CM9/A978). | Zhang Xiaohui Chen Fangping Chen Xiequn Cheng Yunfeng Fang Meiyun Feng Jianming Fu Haixia Gao Hong Han Yue He Aili Hou Ming Hu Yu Huang Ruibin Huang Wenrong Jing Zhicheng Kong Peiyan Liang Aibin Liang Meiying Liu Daihong Liu Junling Liu Lin Liu Xiaowei Ma Liangming Mei Heng Ni Heyu Niu Ting Peng Jun Qiao Jianlin Ren Jinhai Song Yongping Tang Liang V Tong Tong Wang Shaoyuan Wang Xin Wang Zhao Wei Hui Wu Depei Wu Guangsheng Xu Caigang Xu Xue Xu Yajing Yang Linhua Yang Renchi Yang Tonghua Yin Chenghong Yu Li Zhang Guangsen Zhang Lei Zhang Liansheng Zhang Xi Zhao Weili Zhao Yongqiang Zhou Daobin Zhou Hu Zhou Zeping Zhu Tienan Wang Jianliu Huang Xiaojun | 2022 | Chinese Medical Journal2022，，8： | 2 |
| 13 | Formation and Optical Properties of ZnO:ZnFe_(2)O_(4) Superlattice Microwires显示文摘Pure ZnO hexagonal microwires and Fe(Ⅲ)-doped ZnO microwires(MWs)with a novel rectangular cross section were synthesized in a confined chamber by a convenient one-step thermal evaporation method.An oriented attachment mechanism is consistent with a vapor-solid growth process.Photoluminescence(PL)and Raman spectroscopy of the Fe(Ⅲ)-doped ZnO MWs and in situ spectral mappings indicate a quasi-periodic distribution of Fe(Ⅲ)along a one-dimensional(1-D)superlattice ZnO:ZnFe_(2)O_(4) wire,while PL mapping shows the presence of optical multicavities and related multimodes.The PL spectra at room temperature show weak near-edge doublets(376 nm and 383 nm)and a broad band(450-650 nm)composed of strong discrete lines,due to a 1-D photonic crystal structure.Such a 1-D coupled optical cavity material may find many applications in future photonic and spintronic devices. | Yun Li Guozhang Dai Chunjiao Zhou Qinglin Zhang Qiang Wan Limin Fu Jianping Zhang Ruibin Liu Chuanbao Cao Anlian Pan Yunhong Zhang Bingsuo Zou | 2010 | Nano Research2010，3，5： | 2 |
| 14 | 显示文摘 | Zhou Weichang Liu Ruibin Wan Qiang | 2009 | Journal of Physical Chemistry C2009，113，5： | 1 |
| 15 | Stimulated emissions in aligned CdS nanowires at room temperature 显示文摘 | PAN Anlian LIU Ruibin YANG Qing | 2005 | J Plays Chem B2005，109，24： | 1 |
| 16 | Initial velocity field for solution to strip rolling process by rigid plastic FEM 显示文摘 | Mei Ruibin Li Changsheng Liu Xianghua | 2009 | Journal of Northeastern University2009，30，4： | 1 |
| 17 | Morphological changes of BTDA/m - PDA polyimide banded spherulites: The effect of solvent on banding显示文摘 | Zhang Ruibin Liu Xiangyang Gu Yi | 2008 | Journal of Polymer Science Part B: Polymer Physics2008，46，： | 1 |
| 18 | Preparation and characterization of mesoporous silicon spheres directly from MCM-48 and their response to ammonia 显示文摘 | ZHU Jiang LIU Ruibin XU Jun | 2011 | J Ma- ter Sci2011，46，22： | 1 |
| 19 | Coded excitation using biphase-coded pulse with mismatched filters for high- frequency ultrasound imaging 显示文摘 | Hu Changhong Liu Ruibin Zhou Qifa | 2006 | Ultrasonics2006，44，： | 1 |
| 20 | Optimization on technical parameters for fabrication of SDC film by screen-printing used as electrolyte in IT-SOFC显示文摘 | Lijun Zhao Xiqiang Huang Ruibin Zhu Zhe Lu Weiwei Sun Yaohui Zhang Xiaodong Ge Zhiguo Liu Wenhui Su | 2008 | Journal of Physics and Chemistry of Solids2008，，8： | 1 |
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