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| 1 | Parthenogenetic haploid embryonic stem cells produce fertile mice显示文摘 | Haifeng Wan Zhengquan He Mingzhu Dong Tiantian Gu Guan-Zheng Luo Fei Teng Baolong Xia Wei Li Chunjing Feng Xin Li Tianda Li Ling Shua Rui Fu Liu Wang Xiu-Jie Wang Xiao-Yang Zhao Qi Zhou | 2013 | Cell Research2013，23，11： | 13 |
| 2 | Tumor-expressed B7-H3 mediates the inhibition of antitumor T-cell functions in ovarian cancer insensitive to PD-1 blockade therapy显示文摘Although PD-L1/PD-1 blockade therapy has been approved to treat many types of cancers,the majority of patients with solid tumors do not respond well,but the underlying reason remains unclear.Here,we studied ovarian cancer(OvCa),a tumor type generally resistant to current immunotherapies,to investigate PD-1-independent immunosuppression.We found that PD-L1 was not highly expressed in the tumor microenvironment(TME)of human OvCa.Instead,B7-H3,another checkpoint molecule,was highly expressed by both tumor cells and tumor-infiltrating antigen-presenting cells(APCs),which correlated with T-cell exhaustion in patients.Using ID8 OvCa mouse models,we found that B7-H3 expressed on tumor cells,but not host cells,had a dominant role in suppressing antitumor immunity.Therapeutically,B7-H3 blockade,but not PD-1 blockade,prolonged the survival of ID8 tumorbearing mice.Collectively,our results demonstrate that tumor-expressed B7-H3 inhibits the function of CD8^(+)T cells and suggest that B7-H3 may be a target in patients who are not responsive to PD-L1/PD-1 inhibition,particularly OvCa patients. | Dongli Cai Jiaming Li Dingfeng Liu Shanjuan Hong Qin Qiao Qinli Sun Pingping Li Nanan Lyu Tiantian Sun Shan Xie Li Guo Ling Ni Liping Jin Chen Dong | 2020 | Cellular & Molecular Immunology2020，17，3： | 8 |
| 3 | Perovskite light-emitting/detecting bifunctional fibres for wearable LiFi communication显示文摘Light fidelity(LiFi),which is emerging as a compelling technology paradigm shifting the common means of highcapacity wireless communication technologies,requires wearable and full-duplex compact design because of its great significance in smart wearables as well as the‘Internet of Things’.However,the construction of the key component of wearable full-duplex LiFi,light-emitting/detecting bifunctional fibres,is still challenging because of the conflicting process between carrier separation and recombination,as well as the highly dynamic film-forming process.Here,we demonstrate light-emitting/detecting bifunctional fibres enabled by perovskite QDs with hybrid components.The hybrid perovskite inks endow fibres with super-smooth QD films.This,combined with the small exciton binding energy and high carrier mobility of perovskite QDs,enables successful integration of electroluminescence and photodetection into monofilaments.The bifunctional fibres possess the narrowest electroluminescence full width at half maximum of ~19 nm and,more importantly,the capability for simultaneously transmitting and receiving information.The successful fabrication of narrow emission full-duplex LiFi fibres paves the way for the fabrication and integration of low crosstalk interoperable smart wearables. | Qingsong Shan Changting Wei Yan Jiang Jizhong Song Yousheng Zou Leimeng Xu Tao Fang Tiantian Wang Yuhui Dong Jiaxin Liu Boning Han Fengjuan Zhang Jiawei Chen Yongjin Wang Haibo Zeng | 2020 | Light(Science & Applications)2020，9，1： | 7 |
| 4 | A double crosslinking MXene/cellulose nanofiber layered film for improving mechanical properties and stable electromagnetic interference shielding performance显示文摘With the discovery of the two-dimensional(2D) MXene, it shows a great application potential in the field of electromagnetic interference(EMI) shielding, but the mechanical brittleness and easy oxidation of MXene limit its wide application. For this reason, a double crosslinking strategy is provided to solve the above problems in a nacre-like “brick-mortar” layered MXene/cellulose nanofiber(MXene/CNF) film.Typically, the film was firstly suffered by dopamine modification, then was further reinforced by secondary Ca^(2+)bridging, so as to obtain excellent mechanical properties and antioxidative EMI shielding performance. Comparing with the single crosslinking, the double crosslinking strategy reveals a higher efficiency in improving the mechanical property. The mechanical strength and toughness of the double crosslinking MXene/CNF film can increase to 142.2 MPa and 9.48 MJ/m^(3), respectively. More importantly, while achieving good mechanical properties, the MXene composite film still holds a very stable EMI shielding performance of more than 44.6 dB when suffering from the oxidation treatment of hightemperature annealing, showing excellent anti-oxidation ability and environment tolerance. Therefore,this work provides a universal but effective double crosslinking strategy to solve the mechanical brittleness and easy oxidation of MXene-based composites, thus showing a huge potential in flexible EMI shielding applications. | Shilu Luo Tiantian Xiang Jingwen Dong Fengmei Su Youxin Ji Chuntai Liu Yuezhan Feng | 2022 | Journal of Materials Science & Technology2022，，34： | 4 |
| 5 | Hierarchical graphene@MXene composite foam modified with flower-shaped FeS for efficient and broadband electromagnetic absorption显示文摘Developing high-performance broadband microwave absorption material becomes an urgent concern in the field of electromagnetic protection.In this work,an ultralight magnetic composite foam was con-structed by electrostatic self-assembly of MXene on the surface of graphene skeletons,and subsequent hydrothermal anchoring of flower-shaped FeS clusters.Under the synergistic effect of MXene coating in-creasing conductive loss and FeS clusters improving magnetic loss,the rational construction of hierarchi-cal impedance structure in foam can effectively promote the entrance and consumption of more incident electromagnetic waves.The minimum reflection loss(RL min)reaches-47.17 dB at a thickness of 4.78 mm,and the corresponding effective absorption bandwidth(EAB)is up to 6.15 GHz.More importantly,the microwave absorption performance of composite foam can be further optimized by controlling the load-ing of MXene and thermal treatment at a low temperature.The maximum of EAB for GMF-300 can be extended to an unprecedented value of 11.20 GHz(covering 6.10-17.30 GHz). | Shuangshuang Li Xinwei Tang Xu Zhao Shijie Lu Jiangtao Luo Zheyuan Chai Tiantian Ma Qianqian Lan Piming Ma Weifu Dong Zicheng Wang Tianxi Liu | 2023 | Journal of Materials Science & Technology2023，，2： | 4 |
| 6 | Flame-retardant quasi-solid polymer electrolyte enabling sodium metal batteries with highly safe characteristic and superior cycling stability显示文摘Con ventio nal liquid electrolytes based sodium metal batteries suffer from severe safety hazards owing to electrolyte leakage,in flammability and dendritic sodium deposit!on.Herein,we report a flame-retardant quasi-solid polymer electrolyte with poly(methyl vinyl ether-alt-maleic an hydride)(P(MVE-alt-MA))as host,bacterial cellulose(BC)as reinforceme nt,and triethyl phosphate/vinyle ne carb on ate/sodium perchlorate(TEP/VC/NaClO4)as plasticizer for highly safe sodium metal batteries.The as-obtained quasi-solid polymer electrolyte exhibits superior flame retardancy(self-extinguish within 1 s),complete non-leakage property and wide electrochemical windows(4.4 V).More importantly,Na3V2(PO4)3/Na metal batteries using such polymer electrolyte delivers superior I on g-term cycli ng stability(84.4%capacity rete ntion after 1000 cycles)which is significantly better than that(only 2%after 240 cycles)of liquid electrolyte.In addition,this flame-retardant quasi-solid polymer electrolyte provides favorable cycle performance(80.2%capacity retention after 70 cycles at 50°C and 84.8%capacity retention after 50 cycles at-10°C)for Na3V2(PO4)3/Na metal batteries.And this battery also displayed a normal charge/discharge property even at-15°C.These fascinating cycle properties are mainly ascribed to the effective pro怕ctive layers formed on Na3V2(PC>4)3 cathode and sodium metal ano de.More thorough in vestigati on elucidates that such flame-retardant quasi-solid polymer electrolyte plays a multif unctional role in the adva need sodium metal batteries:(1)being in volved in the formatio n of a favorable cathode electrolyte in terface(CEI)to inhibit the dissolutio n of van adium and maintai n the structure integrity of the Na3V2(PO4)3;(2)participati ng in building a stable solid electrolyte in terface(SEI)to suppress the growth of Na dendrites;(3)integrating flame-retardanee into polymer sodium batteries to enhance flame-resistanee,eliminate electrolyte leakage,and thus improve safety of sodium batteries.Based on these results,we further assembled Na3V2(PO4)3/MoS2 pouch cell which can withsta nd harsh conditions(be nded or cut off a corn er),confirming the obtai ned polymer electrolyte with superior non-leakage property.In all,these outstanding characteristics would endow this flame-retardant quasi-solid polymer electrolyte a very promising can didate for highly-safe sodium metal batteries. | Jinfeng Yang Min Zhang Zheng Chen Xiaofan Du Suqi Huang Ben Tang Tiantian Dong Han Wu Zhe Yu Jianjun Zhang Guanglei Cui | 2019 | Nano Research2019，12，9： | 4 |
| 7 | Polymer electrolytes for Li-S batteries:Polymeric fundamentals and performance optimization显示文摘Lithium-sulfur(Li-S) batteries have been considered as one of the most promising candidates to traditional lithium ion batteries due to its low cost,high theoretical specific capacity(1675 mAh g^(-1)) and energy density(2600 Wh kg^(-1)) of sulfur.Compared with traditional liquid electrolytes,polymer electrolytes(PEs) are ever-increasingly preferred due to their higher safety,superior compatibility,long cycling stability and so on.Despite some progresses on PEs,however,there remain lots of hurdles to be addressed prior to commercial applications.This review begins with native advantages for PEs to replace LEs,and then proposes the ideal requirements for PEs.Furthermore,a brief development history of typical PEs for Li-S batteries is presented to systematically summarize the recent achievements in Li-S batteries with PEs.Noted that the structure-performance relationships of polymer matrixes for PEs are highlighted.Finally,the challenges and opportunities on the future development of PEs are presented.We hold the view that composite polymer electrolytes in virtue of the high ionic conductivity and the compatible interfacial property will be promising solution for high performance Li-S batteries. | Meifang Jiang Zengqi Zhang Ben Tang Tiantian Dong Hantao Xu Huanri Zhang Xiaolan Lu Guanglei Cui | 2021 | Journal of Energy Chemistry2021，30，7： | 3 |
| 8 | High-risk phenotypes of genetic disease in a Neonatal Intensive Care Unit population显示文摘To the Editor: Genetic diseases contribute to 35% of deaths during the first year of life and are a significant cause of intensive care.[1] A previous study based on the China Neonatal Genomes Project investigated the genetic causes of early infant deaths and found that >25% of deceased neonates with genetic diagnoses can be cured if diagnosed in time.[2] Therefore, it is crucial to target and diagnose neonates with genetic diseases as early as possible. According to our experience, the typical phenotypes, such as special facial features or multiple congenital anomalies (MCAs), indicate a high risk of genetic disease and lead physicians to perform genetic testing in neonates as early as possible. However, in practice, infants without typical phenotypes typically undergo a long and costly diagnostic process before genetic diagnoses are confirmed. Moreover, a recent survey by the American College of Medical Genetics and Genomics (ACMG) and other national professional organizations indicated that there are insufficient numbers of qualified geneticists to fulfil genetic service needs.[3] The ACMG published the general clinical features for genetic testing indications. For example, patients with phenotypes or family history data that strongly implicate a genetic cause may undergo genetic testing.[1] However, the study indicated that many genetic conditions arise de novo or are inherited with no family history.[1] A previous study attempted to apply the non-phenotype-driven panel approach in neonates admitted to the neonate intensive care unit (NICU).[4] However, at present, the diagnostic yield is only 3.45% (1/29).[4] In addition, the economic and ethical issues associated with genomic screening remain challenging. Therefore, the available indications for genetic testing may improve the management of genetic diseases. | Tiantian Xiao Qi Ni Huiyao Chen Huijun Wang Lin Yang Bingbing Wu Yun Cao Guoqiang Cheng Laishuan Wang Liyuan Hu Hongfang Mei Yulan Lu Mengchun Gong Xinran Dong Wenhao Zhou | 2022 | Chinese Medical Journal2022，，5： | 2 |
| 9 | MicroRNA-628-5p Facilitates Enterovirus 71 Infection by Suppressing TRAF3 Signaling显示文摘To date,EV71 infection still poses a great challenge to the health of infants and young children.1 Much established evidence suggests that EV71 infection depends on a wide variety of host factors,including cell surface receptors for EV71 entry,innate immune response,miRNAs,and lncRNAs.2,3 It is thought that diverse signaling pathways are required for EV71 to escape the host immune response.4 Innate immunity serves as the first line of defense against pathogens.Tumor necrosis factor receptor-associated factor(TRAF)proteins are essential components of signaling pathways activated by Toll-like receptor(TLR)or RIG-I-like receptor(RLR)family members.TRAF3 is widely expressed by many cell types,including all nucleated immune cells,in which it plays many roles in the regulation of immune functions.5 TRAF3 plays a significant role in regulating the functions of B and T lymphocytes.TRAF3 is a highly versatile regulator that positively controls type I interferon and cytokine production through interferon regulatory factors(IRFs)and nuclear factor-κB(NF-κB).6 A recent study indicated that EV71-induced ubiquitin-specific protease 19(USP19)negatively regulates type I IFN signaling by targeting TRAF3. | Dong Li Shuaiyin Chen Weiguo Zhang Chao Zhang Tiantian Sun Yue Du Ronghua Ding Yanlei Gao Yuefei Jin Guangcai Duan | 2021 | Cellular & Molecular Immunology2021，18，5： | 2 |
| 10 | EETs and CYP2J2 inhibit TNF-α-induced apoptosis in pulmonary arteryendothelial cells and TGF-β1-induced migration in pulmonary artery smooth musclecells显示文摘 | Wenjing Feng Xizhen Xu Gang Zhao Geng Li Tiantian Liu Junjie Zhao Ruolan Dong Dao Wang Ling Tu | 2013 | International Journal of Molecular Medicine2013，，3： | 2 |
| 11 | PM_(2.5) exposure associated with microbiota gut-brain axis:Multi-omics mechanistic implications from the BAPE study显示文摘Recent studies have shown that PM_(2.5) may activate the hypothalamus-pituitary-adrenal(HPA)axis by inducing hormonal changes,potentially explaining the increase in neurological and cardiovascular risks.In addition,an association between PM_(2.5) and gut microbiota and metabolites was established.The above evidence represents crucial parts of the gut-brain axis(GBA).In view of this evidence. | Tiantian Li Jianlong Fang Song Tang Hang Du Liang Zhao Yanwen Wang Fuchang Deng Yuanyuan Liu Yanjun Du Liangliang Cui Wanying Shi Yan Wang Jiaonan Wang Yingjian Zhang Xiaoyan Dong Ying Gao Yu Shen Li Dong Huichan Zhou Qinghua Sun Haoran Dong Xiumiao Peng Yi Zhang Meng Cao Hong Zhi Jingyang Zhou Xiaoming Shi | 2022 | The Innovation2022，3，2： | 2 |
| 12 | An Endotenon Sheath-Inspired Double-Network Binder Enables Superior Cycling Performance of Silicon Electrodes显示文摘Silicon(Si)has been regarded as an alternative anode material to traditional graphite owing to its higher theoretical capacity(4200 vs.372 m Ah g;).However,Si anodes suffer from the inherent volume expansion and unstable solid electrolyte interphase,thus experiencing fast capacity decay,which hinders their commercial application.To address this,herein,an endotenon sheathinspired water-soluble double-network binder(DNB)is presented for resolving the bottleneck of Si anodes.The as-developed binder shows excellent adhesion,high mechanical properties,and a considerable self-healing capability mainly benefited by its supramolecular hybrid network.Apart from these advantages,this binder also induces a Li;N/Li F-rich solid electrolyte interface layer,contributing to a superior cycle stability of Si electrodes.As expected,the DNB can achieve mechanically more stable Si electrodes than traditional polyacrylic acid and pectin binders.As a result,DNB delivers superior electrochemical performance ofSi/Li half cells and Li Ni;Co;Mn;O;/Si full cells,even with a high loading of Si electrode,to traditional polyacrylic acid and pectin binders.The bioinspired binder design provides a promising route to achieve long-life Si anode-assembled lithium batteries. | Meifang Jiang Pengzhou Mu Huanrui Zhang Tiantian Dong Ben Tang Huayu Qiu Zhou Chen Guanglei Cui | 2022 | Nano-Micro Letters2022，14，6： | 2 |
| 13 | 艾森克人格特质与人际困扰对大学生网络成瘾的影响显示文摘探讨人格特质与人际困扰对大学生网络成瘾的影响机制,为预防和改善大学生网络成瘾提供干预策略和理论支持。采用网络成瘾量表、人际关系诊断量表、艾森克人格问卷对400名大学生进行随机施测。结果发现神经质、精神质、人际困扰与网络成瘾均两两显著正相关;外倾性与网络成瘾显著负相关;外倾性与人际困扰显著负相关。通过分层回归分析结果表明,神经质、精神质能正向预测大学生网络成瘾,外倾性负向预测大学生网络成瘾;人际困扰在人格特质与网络成瘾之间起中介作用,其中人际困扰在神经质对网络成瘾的影响中起着完全中介作用,人际困扰在精神质、外倾性对网络成瘾的影响中起着部分中介的作用。 | 夏艳雨 晋争 惠秋平 赵凯宾 李营 DONG Tiantian | 2022 | 牡丹江师范学院学报(社会科学版)2022，，1： | 2 |
| 14 | Investigation of hemostatic effect of Spleeninvigorating,Qi-replenishing and Bloodarresting Formula on simvastatin-induced zebrafish hemorrhage model显示文摘Blood-arresting Formula on simvastatin-induced zebrafish hemorrhage model compared with that of the Heat-clearing and Blood-cooling Formula.Methods:AB strain wild type zebrafish were treated with 0.5 mM simvastatin for 24 hours to establish the zebrafish hemorrhage model.Under strictly blind experimental conditions,the zebrafish were then treated with experimental agents in different concentration within the maximum non-lethal dose.The intervention effect of the Spleen-invigorating,Qi-replenishing and Blood-arresting Formula was comprehensively assessed by examining the main observational parameters such as the bleeding reduction rate and hemostatic rate while referring to the additional parameters such as blood flow,improvement rate of blood flow,velocity of movement,improvement rate of motion under spleen-qi deficiency.Results:Hemostatic effect:The bleeding rate and hemostatic rate in the zebrafish were respectively,30%,15%,45%,40%and 60%,80%,40%,47%when equal concentration of 500 mg/mL,1000 mg/mL were used.This showed that the experimental herbs B1 was superior to B2 in decreasing the bleeding rate and improving hemostatic effect in the zebrafish.Improvement of blood flow:With equal concentration,the experimental herb B1 was superior to B2 in increasing the blood flow and improvement rate of blood flow in hemorrhagic zebrafish.Promotion of the improvement of motion:With equal concentration of 500 mg/mL and 1000 mg/mL,the experimental herb B1 was superior to B2 in promoting the velocity of motion in the zebrafish and promoting the improvement rate of motion.Conclusion:The manifestations of simvastatin-induced zebrafish hemorrhage are basically similar to that of failure of the spleen to control blood in human beings.The Spleeninvigorating,Qi-replenishing and Blood-arresting Formula has good hemostatic effect on simvastatin-induced hemorrhage in the zebrafish.It also boasts the functions of improving blood flow and velocity of motion in the hemorrhagic zebrafish.Such a conclusion provides the experimental basis for the treatment of the syndrome of failure of the spleen to control blood by this formula. | Yuting Chu Ling Zhang Xiaoyu Zhu Yayue Zhang Bo Xia Li Hou Rushun Song Tiantian Li Chunqi Li Qing Dong a Xinyi Chen | 2016 | Journal of Traditional Chinese Medical Sciences2016，3，4： | 1 |
| 15 | TLSmell: Direct Identification on Malicious HTTPs Encryption Traffic withSimple Connection-Specific Indicators显示文摘Internet traffic encryption is a very common traffic protection method.Most internet traffic is protected by the encryption protocol called transport layersecurity (TLS). Although traffic encryption can ensure the security of communication, it also enables malware to hide its information and avoid being detected.At present, most of the malicious traffic detection methods are aimed at the unencrypted ones. There are some problems in the detection of encrypted traffic, suchas high false positive rate, difficulty in feature extraction, and insufficient practicability. The accuracy and effectiveness of existing methods need to be improved.In this paper, we present TLSmell, a framework that conducts maliciousencrypted HTTPs traffic detection with simple connection-specific indicators byusing different classifiers based online training. We perform deep packet analysisof encrypted traffic through data pre-processing to extract effective features, andthen the online training algorithm is used for training and prediction. Withoutdecrypting the original traffic, high-precision malicious traffic detection and analysis are realized, which can guarantee user privacy and communication security.At the same time, since there is no need to decrypt the traffic in advance, the effi-ciency of detecting malicious HTTPs traffic will be greatly improved. Combinedwith the traditional detection and analysis methods, malicious HTTPs traffic isscreened, and suspicious traffic is further analyzed by the expert through the context of suspicious behaviors, thereby improving the overall performance of malicious encrypted traffic detection. | Zhengqiu Weng Timing Chen Tiantian Zhu Hang Dong Dan Zhou Osama Alfarraj | 2021 | Computer Systems Science & Engineering2021，37，4： | 1 |
| 16 | Primary Research of EIT Inverse Problem Based on CS (Compressed Sensing) Technique显示文摘 | CHANG Tiantian DAI Meng XU Canhua FU Feng YOU Fusheng DONG Xiuzhen | 2013 | Journal of Mathematics and System Science2013，3，1： | 1 |
| 17 | A Prognostic Nomogram for Hepatocellular Carcinoma Based on Wound Healing and Immune Checkpoint Genes显示文摘Background and Aims:Wound healing and tumor progression share some common biological features;however,how variations in wound healing patterns affect hepatocellular carcinoma(HCC)prognosis remains unclear.Methods:We analyzed the wound healing patterns of 594 HCC samples from The Cancer Genome Atlas(TCGA)and the International Cancer Genome Consortium(ICGC)and correlated them with immune infiltration and the expression levels of immune checkpoint genes.A risk score,which we named the“heal.immune”score,was established via stepwise Cox estimation.We constructed a nomogram based on age,sex,TNM stage,and heal.immune score and explored its predictive value for HCC prognosis.Seventy-four clinical patients were enrolled in this study,and all were from Huashan Hospital of Fudan University between 2015 and 2017 to serve as an independent validation group.Results:We identified two distinct wound healing patterns in HCC.The biological processes of healing cluster 1(C1)are related to metabolism,while those of healing cluster 2(C2)are related to the inflammatory response and immune cell accumulation.A total of 565 wound healing-related genes(based on Gene Ontology)and 25 immune checkpoint genes were considered.By analyzing differentially expressed genes and implementing a stepwise Cox estimation analysis,six genes with p values less than 0.02 in a multivariate Cox estimation were chosen as the“heal.immune”gene set(FCER1G,PLAT,ITGA5,CCNB1,CD86 and CD40).The“heal.immune”gene set,as an OS risk factor,was further validated in Fudan cohort.We constructed a nomogram to predict the 1-,3-and 5-year overall survival(OS)in the TCGA cohort.The area under curve vales of the receiver characteristic operator curves were 0.82,0.76 and 0.73 in the training group and 0.84,0.76 and 0.72 in the test group.Conclusions:We established a prognostic nomogram based on the heal.immune gene signature,which includes six wound healing-and immunity-related genes.This nomogram accurately predicts the OS of HCC patients. | Beiyuan Hu Xiaotian Shen Wei Qin Lan Zhang Tiantian Zou Qiongzhu Dong Lun-Xiu Qin | 2022 | Journal of Clinical and Translational Hepatology2022，10，5： | 1 |
| 18 | Exosomal S100A4 derived from highly metastatic hepatocellular carcinoma cells promotes metastasis by activating STAT3显示文摘Intercellular cross-talk plays important roles in cancer progression and metastasis.Yet how these cancer cells interact with each other is still largely unknown.Exosomes released by tumor cells have been proved to be effective cell-to-cell signal mediators.We explored the functional roles of exosomes in metastasis and the potential prognostic values for hepatocellular carcinoma(HCC).Exosomes were extracted from HCC cells of different metastatic potentials.The metastatic effects of exosomes derived from highly metastatic HCC cells(HMH)were evaluated both in vitro and in vivo.Exosomal proteins were identified with iTRAQ mass spectrum and verified in cell lines,xenograft tumor samples,and functional analyses.Exosomes released by HMH significantly enhanced the in vitro invasion and in vivo metastasis of low metastatic HCC cells(LMH).S100 calcium-binding protein A4(S100A4)was identified as a functional factor in exosomes derived from HMH.S100A4r,ch exosomes significantly promoted tumor metastasis both in vitro and in vivo compared with S100A4^(rich) exosomes or controls.Moreover,exosomal S100A4 could induce expression of osteopontin(OPN),along with other tumor metastasis/stemness-related genes.Exosomal S100A4 activated OPN transcription via STAT3 phosphorylation.HCC patients with high exosomal S100A4 in plasma also had a poorer prognosis.In conclusion,exosomes from HMH could promote the metastatic potential of LMH,and exosomal S100A4 is a key enhancer for HCC metastasis,activating STAT3 phosphorylation and up-regulating OPN expression.This suggested exosomal S100A4 to be a novel prognostic marker and therapeutic target for HCC metastasis. | Haoting Sun Chaoqun Wang Beiyuan Hu Xiaomei Gao Tiantian Zou Qin Luo Mo Chen Yan Fu Yuanyuan Sheng Kaili Zhang Yan Zheng Xudong Ren Shican Yan Yan Geng Luyu Yang Qiongzhu Dong Lunxiu Qin | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 1 |
| 19 | Durable pluripotency and haploidy in epiblast stem cells derived from haploid embryonic stem cells in vitro显示文摘Haploid pluripotent stem cells,such as haploid embryonic stem cells(haESCs),facilitate the genetic study of recessive traits.In vitro,fish haESCs maintain haploidy in both undifferentiated and differentiated states,but whether mammalian haESCs can preserve pluripotency in the haploid state has not been tested.Here,wereport thatmousehaESCs can differentiate in vitro into haploid epiblast stem cells(haEpiSCs),which maintain an intact haploid genome,unlimited self-renewal potential,and durable pluripotency to differentiate into various tissues in vitro and in vivo.Mechanistically,the maintenance of self-renewal potential depends on the Activin/bFGF pathway.We further show that haEpiSCs can differentiate in vitro into haploid progenitor-like cells.When injected into the cytoplasm of an oocyte,androgenetic haEpiSC(ahaEpiSCs)can support embryonic development until midgestation(E12.5).Together,these resultsdemonstrate durable pluripotency inmousehaESCs andhaEpiSCs,aswell asthe valuable potential of using these haploid pluripotent stem cells in high-throughput genetic screening. | Ling Shuai Yukai Wang Mingzhu Dong Xuepeng Wang Lisi Sang Mei Wang Haifeng Wan Guanzheng Luo Tiantian Gu Yan Yuan Chunjing Feng Fei Teng Wei Li Xiuying Liu Tianda Li Liu Wang Xiu-Jie Wang Xiao-Yang Zhao Qi Zhou | 2015 | Journal of Molecular Cell Biology2015，7，4： | 1 |
| 20 | How Do Polymer Binders Assist Transition Metal Oxide Cathodes to Address the Challenge of High‑Voltage Lithium Battery Applications?显示文摘Research on the chemistry of high-energy-density transition metal oxide cathodes(TMOCs)is at the forefront in the pursuit of lithium-ion batteries with increased energy density.As a critical component of these cathodes,binders not only glue cathode active material particles and conducting carbons together and to current collectors but also play pivotal roles in building multiscale compatible interphases between electrolytes and cathodes.In this review,we outline several vital design considerations of high-voltage binders,several of which are already present in traditional binder design that need to be highlighted,and systematically reveal the chemistry and mechanisms underpinning such binders for in-depth understanding.Further optimization of the design of polymer binders to improve battery performance is also discussed.Finally,perspec-tives regarding the future rational design and promising research opportunities of state-of-the-art binders for high-voltage TMOCs are presented. | Tiantian Dong Pengzhou Mu Shu Zhang Huanrui Zhang Wei Liu Guanglei Cui | 2021 | Electrochemical Energy Reviews2021，4，3： | 1 |
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