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| 1 | Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study显示文摘Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy. | Zhi Peng Tianshu Liu Jia Wei Airong Wang Yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming Xu Qingxia Fan Ruihua Xu Liangming Zhang Enxiao Li Yuping Sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer Ying Xinjun Liang Nong Xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang Yi Ba Lin Shen | 2021 | Cancer Communications2021，41，11： | 29 |
| 2 | Stereotactic aspiration for hypertensive intracerebral haemorrhage in a Chinese population:a retrospective cohort study显示文摘Objective We aimed to compare the therapeutic effects of stereotactic aspiration and best medical management in patients who developed supratentorial hypertensive intracerebral haemorrhage(HICH)with a volume of haemorrhage between 20 and 40 mL.Methods The clinical data of 220 patients with supratentorial HICH with a volume between 20 and 40 mL were retrospectively analysed.Among them,142 received stereotactic aspiration surgery(stereotactic aspiration group)and 78 received best medical management(conservative group).All were followed up for 6 months.Multivariate logistic regression and Kaplan-Meier survival curves were used to compare the outcome between the two groups.results The rebleeding rate was lower in the group that had stereotactic aspiration when compared with the group with medical treatment(6[4.2%]vs 9[11.5%],χ2=4.364,p=0.037).After 6 months,although the mortality rate did not differ significantly between the two groups(8 cases[5.6%]vs 10 cases[12.8%],χ2=3.461,p=0.063),the rate of a favourable outcome was higher in the group who received stereotactic aspiration(χ2=15.870,p=0.000).Logistic regression identified that medical treatment(OR=1.64,p=0.000)was an independent risk factor for an unfavourable outcome.The Kaplan-Meier curves indicated that the median favourable outcome time in the stereotactic aspiration group was 59.5 days compared with that in the medically treated group(87.0 days).The log-rank test indicated that the prognosis at 6 months was better for those treated with stereotactic haematoma aspiration(χ2=29.866,p=0.000).However,the 6-month survival rate was similar between the two groups(χ2=3.253,p=0.068).Conclusions Stereotactic haematoma aspiration significantly improved the quality of life,although did not effectively reduce the rate of mortality.When selected appropriately,patients with HICH may benefit from this type of surgical intervention. | Xuyang Zhang Shaolong Zhou Qiang Zhang Xudong Fu Yuehui Wu Jiasheng Liu Bo Liang Zhuo Yang Xinjun Wang | 2019 | Stroke & Vascular Neurology2019，4，1： | 19 |
| 3 | Inherent mechanism of breakdown in laminar-turbulent transition of plane channel flows显示文摘Laminar-turbulent transition is an old yet unsolved problem. Notwithstanding the great effort made, there is an important question that seems not to have been addressed yet, that is, what is the inherent mechanism of breakdown that eventually leads to transition? The conventional idea is that the transition starts from the amplification of disturbances, and when the disturbances become larger, higher harmonics will be generated due to nonlinear effect, making the flow more and more complicated, and finally turbulent. Though the scenario seems clear, yet there is a missing link, that is, what happens in the breakdown process. Here we show by analyzing the results from direct numerical simulations that the change of stability characteristics of the mean flow profile plays a key role in the breakdown process. | LUO Jisheng, WANG Xinjun & ZHOU Heng Department of Mechanics, Tianjin University Liu-Hui Center of Mathematics, Nankai and Tianjin University, Tianjin 300071, China | 2005 | Science China(Physics,Mechanics & Astronomy)2005，48，2： | 14 |
| 4 | Optimal design of a new spatial 3-DOF parallel robot with respect to a frame-free index显示文摘Optimal design is one of the most important issues in robots. Since the very beginning, the concepts of the Jacobian matrix, manipulability and condition number, which are used successfully in the field of serial robots, have been applied to parallel robots. Unlike serial robots, parallel robots are good for motion/force transmission. Their performance evaluation and design should be correspondingly dif- ferent. This paper is an attempt to optimally design a novel spatial three-degree-of-freedom (3-DOF) parallel robot by using the concept of motion/force transmission. Accordingly, three indices are defined. The suggested indices are independent of any coordinate frame and could be applied to the analysis and design of a parallel robot whose singularities can be identified wholly by using the relative angle between the output and adjacent links, and by using the relative angle between the input and adjacent links. | JinSong Wang XinJun Liu Chao Wu | 2009 | Science China(Technological Sciences)2009，52，4： | 12 |
| 5 | Effect of microbial mediated iron plaque reduction on arsenic mobility in paddy soil显示文摘The potential of microbial mediated iron plaque reduction, and associated arsenic (As) mobility were examined by iron reducing bacteria enriched from As contaminated paddy soil. To our knowledge, this is the first time to report the impact of microbial iron plaque reduction on As mobility. Iron reduction occurred during the inoculation of iron reducing enrichment culture in the treatments with iron plaque and ferrihydrite as the electron acceptors, respectively. The Fe(II) concentration with the treatment of anthraquinone-2, 6-disulfonic acid (AQDS) and iron reducing bacteria increased much faster than the control. Arsenic released from iron plaque with the iron reduction, and a significant correlation between Fe(II) and total As in culture was observed. However, compared with control, the increasing rate of As was inhibited by iron reducing bacteria especially in the presence of AQDS. In addition, the concentrations of As(III) and As(V) in abiotic treatments were higher than those in the biotic treatments at day 30. These results indicated that both microbial and chemical reductions of iron plaque caused As release from iron plaque to aqueous phase, however, microbial iron reduction induced the formation of more crystalline iron minerals, leading to As sequestration. In addition, the presence of AQDS in solution can accelerate the iron reduction, the As release from iron plaque and subsequently the As retention in the crystalline iron mineral. Thus, our results suggested that it is possible to remediate As contaminated soils by utilizing iron reducing bacteria and AQDS. | WANG Xinjun CHEN Xueping YANG Jing WANG Zhaosu SUN Guoxin | 2009 | Journal of Environmental Sciences2009，21，11： | 11 |
| 6 | Spatiotemporal change of ecological footprint and sustainability analysis for Yangtze Delta Region显示文摘在城市化的世界上, Yangtze 三角洲区域(YDR ) 在中国作为大多数之一开发了区域,绘画了很多为显著经济发展的世界注意在过去的十年完成了。不过,快速的经济发展肯定被自然资源的崭新的消费和损失伴随。因此,生态的状况的分析和环境影响的开车因素意义大提供本地持续发展决策并且造一个和谐社会。在这份报纸,生态的脚印(EF ) 作为生态的环境影响的索引被拿。在地理信息系统(GIS ) 的帮助下,我们在二规模(区域和城市) 学习了生态的脚印的空间与时间的变化并且在 YDR 估计了城市的持续发展能力。然后,我们讨论了在人口,富裕,和技术(STIRPAT ) 模型上由回归由随机的影响影响了生态的脚印的变化的开车因素。结果证明(1.702.53 ha/cap ) 在 19982008 期间增加地区性的生态的脚印的趋势被减少的生态的能力(0.310.25 ha/cap ) 伴随,但是扩展生态的赤字(1.392.28 ha/cap ) 。生态的脚印和持续开发的度的分发模式在 YDR 从城市清楚地变化了到城市。在 2008,生态的脚印(3.85 ha/cap ) 的最高的值并且最低在 YDR 的持续开发索引(SDI=1 ) 之一两个都在上海被介绍。GDP 人均的(A) 是 EF 的最主导的驱动力,古典 EKC 假设没在 19982008 在 A 和 EF 之间存在。因而,在生态的供应增加并且由于工艺的进展或另外的因素在人的需求减少是在 YDR 支持持续开发的最有效的方法之一。而且,重要性应该被依附改变我们繁荣和成功的定义和测量。 | WANG Ping WANG Xinjun | 2011 | Journal of Geographical Sciences2011，21，5： | 10 |
| 7 | Development and validation of an endoscopic images-based deep learning model for detection with nasopharyngeal malignancies显示文摘Background:Due to the occult anatomic location of the nasopharynx and frequent presence of adenoid hyperpla-sia,the positive rate for malignancy identification during biopsy is low,thus leading to delayed or missed diagnosis for nasopharyngeal malignancies upon initial attempt.Here,we aimed to develop an artificial intelligence tool to detect nasopharyngeal malignancies under endoscopic examination based on deep learning.Methods:An endoscopic images-based nasopharyngeal malignancy detection model(eNPM-DM)consisting of a fully convolutional network based on the inception architecture was developed and fine-tuned using separate training and validation sets for both classification and segmentation.Briefly,a total of 28,966 qualified images were collected.Among these images,27,536 biopsy-proven images from 7951 individuals obtained from January 1st,2008,to December 31st,2016,were split into the training,validation and test sets at a ratio of 7:1:2 using simple randomiza-tion.Additionally,1430 images obtained from January 1st,2017,to March 31st,2017,were used as a prospective test set to compare the performance of the established model against oncologist evaluation.The dice similarity coef-ficient(DSC)was used to evaluate the efficiency of eNPM-DM in automatic segmentation of malignant area from the background of nasopharyngeal endoscopic images,by comparing automatic segmentation with manual segmenta-tion performed by the experts.Results:All images were histopathologically confirmed,and included 5713(19.7%)normal control,19,107(66.0%)nasopharyngeal carcinoma(NPC),335(1.2%)NPC and 3811(13.2%)benign diseases.The eNPM-DM attained an overall accuracy of 88.7%(95%confidence interval(CI)87.8%-89.5%)in detecting malignancies in the test set.In the prospective comparison phase,eNPM-DM outperformed the experts:the overall accuracy was 88.0%(95%CI 86.1%-89.6%)vs.80.5%(95%CI 77.0%-84.0%).The eNPM-DM required less time(40 s vs.110.0±5.8 min)and exhibited encouraging performance in automatic segmentation of nasopharyngeal malignant area from the background,with an average DSC of 0.78±0.24 and 0.75±0.26 in the test and prospective test sets,respectively.Conclusions:The eNPM-DM outperformed oncologist evaluation in diagnostic classification of nasopharyngeal mass into benign versus malignant,and realized automatic segmentation of malignant area from the background of nasopharyngeal endoscopic images. | Chaofeng Li Bingzhong Jing Liangru Ke Bin Li Weixiong Xia Caisheng He Chaonan Qian Chong Zhao Haiqiang Mai Mingyuan Chen Kajia Cao Haoyuan Mo Ling Guo Qiuyan Chen Linquan Tang Wenze Qiu Yahui Yu Hu Liang Xinjun Huang Guoying Liu Wangzhong Li Lin Wang Rui Sun Xiong Zou Shanshan Guo Peiyu Huang Donghua Luo Fang Qiu Yishan Wu Yijun Hua Kuiyuan Liu Shuhui Lv Jingjing Miao Yanqun Xiang Ying Sun Xiang Guo Xing Lv | 2018 | Cancer Communications2018，38，1： | 9 |
| 8 | Step kinematic calibration of a 3-DOF planar parallel kinematic machine tool显示文摘This paper presents a novel step kinematic calibration method for a 3 degree-of-freedom(DOF) planar parallel kinematic machine tool,based on the minimal linear combinations(MLCs) of error parameters.The method using mapping of linear combinations of parameters in error transfer multi-parameters coupling system changes the modeling,identification and error compensation of geometric parameters in the general kinematic calibration into those of linear combinations of parameters.By using the four theorems of the MLCs,the sets of the MLCs that are respectively related to the relative precision and absolute precision are determined.All simple and feasible measurement methods in practice are given,and identification analysis of the set of the MLCs for each measurement is carried out.According to the identification analysis results,a step calibration including step measurement,step identification and step error compensation is determined by taking into account both measurement costs and observability.The experiment shows that the proposed method has the following merits:(1) the parameter errors that cannot influence precision are completely avoided;(2) it reflects the mapping of linear combinations of parameters more accurately and enhances the precision of identification;and(3) the method is robust,efficient and effective,so that the errors in position and orientation are kept at the same order of the measurement noise.Due to these merits,the present method is attractive for the 3-DOF planar parallel kinematic machine tool and can be also applied to other parallel kinematic machine tools with weakly nonlinear kinematics. | CHANG Peng,WANG JinSong,LI TieMin,LIU XinJun & GUAN LiWen Department of Precision Instruments and Mechanology,Tsinghua University,Beijing 100084,China | 2008 | Science China(Technological Sciences)2008，51，12： | 9 |
| 9 | 声波激励的超小型纳机电系统磁电天线显示文摘当前的小型天线依赖于电磁波的谐振,因此天线的尺寸与电磁波波长相关。典型的天线尺寸大于波长的1/10,而进一步缩小天线尺寸在近十年来都是一个公开的挑战。介绍一种通过悬浮铁氧/压电薄膜异质结构的声波激励纳机械磁电天线。这种磁电天线通过其在声波谐振频率处的磁电效应接收和发射电磁波。磁电天线中的体声波激发铁磁薄膜的磁化振荡,产生电磁波的辐射;反之,天线感应电磁波的磁场,得到压电电压输出。这种磁电天线(尺寸仅为波长的千分之一)比现有小型天线的尺寸小1到2个数量级,但性能却没有降低,在便携式无线通信系统中具有很大的应用潜力。 | Tianxiang Nan Hwaider Lin Yuan Gao Alexei Matyushov Guoliang Yu Huaihao Chen Neville Sun Shengjun Wei Zhiguang Wang Menghui Li Xinjun Wang Amine Belkessam Rongdi Guo Brian Chen James Zhou Zhenyun Qian Yu Hui Matteo Rinaldi Michael E.McConney BrANDon M.Howe Zhongqiang Hu John G.Jones Gail J.Brown Nian Xiang Sun 张建强(翻译) 陈鼎鼎(审校) | 2017 | 通信对抗2017，36，4： | 8 |
| 10 | Projecting distributions of Argentine shortfin squid(Illex argentinus)in the Southwest Atlantic using a complex integrated model显示文摘We developed an approach that integrates generalized additive model(GAM) and neural network model(NNM)for projecting the distribution of Argentine shortfin squid(Illex argentinus). The data for this paper was based on commercial fishery data and relevant remote sensing environmental data including sea surface temperature(SST), sea surface height(SSH) and chlorophyll a(Chl a) from January to June during 2003 to 2011. The GAM was used to identify the significant oceanographic variables and establish their relationships with the fishery catch per unit effort(CPUE). The NNM with the GAM identified significant variables as input vectors was used for predicting spatial distribution of CPUE. The GAM was found to explain 53.8% variances for CPUE. The spatial variables(longitude and latitude) and environmental variables(SST, SSH and Chl a) were significant. The CPUE had nonlinear relationship with SST and SSH but a linear relationship with Chl a. The NNM was found to be effective and robust in the projection with low mean square errors(MSE) and average relative variances(ARV).The integrated approach can predict the spatial distribution and explain the migration pattern of Illex argentinus in the Southwest Atlantic Ocean. | WANG Jintao CHEN Xinjun CHEN Yong | 2018 | Acta Oceanologica Sinica2018，37，8： | 8 |
| 11 | Analysis of genetic diversity and population structure of Chinese yak breeds (Bos grunniens) using microsatellite markers显示文摘Nine Chinese yak breeds (Maiwa, Tianzhu White, Qinghai Plateau, Sibu, Zhongdian, Pali, Tibetan High Mountain, Jiulong, and Xin-jiang) and Gayal were analyzed by means of 16 microsatellite markers to determine the level of genetic variation within populations, genetic relationship between populations, and population structure for each breed. A total of 206 microsatellite alleles were observed. Mean F-statistics (0.056) for 9 yak breeds indicated that 94.4% of the genetic variation was observed within yak breeds and 5.6% of the genetic variation existed amongst breeds. The Neighbor-Joining phylogenetic tree was constructed based on Nei's standard genetic dis-tances and two clusters were obtained. The Gayal separated from the yaks far away and formed one cluster and 9 yak breeds were grouped together. The analysis of population structure for 9 yak breeds and the Gayal showed that they resulted in four clusters; one clus-ter includes yaks from Tibet Autonomous Region and Qinghai Province, one cluster combines Zhongdian, Maiwa, and Tianzhu White, and Jiulong and Xinjiang come into the third cluster. Pali was mainly in the first cluster (90%), Jiulong was mainly in the second cluster (87.1%), Zhongdian was primarily in the third cluster (83%), and the other yak breeds were distributed in two to three clusters. The Gayal was positively left in the fourth cluster (99.3%). | Guixiang Zhang Weisheng Chen Ming Xue Zhigang Wang Hong Chang Xu Han Xinjun Liao Donglei Wang | 2008 | Journal of Genetics and Genomics2008，35，4： | 8 |
| 12 | Analysis of factors influencing moxibustion efficacy by affecting heat-activated transient receptor potential vanilloid channels显示文摘Moxibustion is an important component part of Traditional Chinese Medicine(TCM).Among different kinds of moxibustion methods,thermal stimulation seems to be a pivotal impact factor to the theraputic efficacy.Based on its thermal characteristic and treated area-skin,we hypothesize that the thermosensitive TRPV channels may involve in the mechanism of moxibustion.This study,by referring to various experimental and clinical data,analyzes the properties and features of transient receptor potential vanilloid(TRPV)subfamily 1-4 and the impact of moxibustion on these channels.The factors impacting the efficacy of moxibustion treatment were analyzed on three levels:the independent ba-sic factors of moxibustion(temperature,space and time);moxibustion intensity(a compound factor achieved through comprehensive control of the three individual basic factors mentioned above);and moxibustion quantity(the amount of temperature stimulation applied within a certain unit of time,including the total amount of moxibustion treatment).The results from present study show that the effect of moxibustion therapy appears to be determined by the activation of TRPV1-4,mainly TRPV1 and TRPV2.Temperature(the degree of heat stimulation),time and area(how long the treatment lasts and how many TRPV1-4 channels are activated)affect the intensity of moxibustion treatment to form effective moxibustion quantity;this should be considered in clinical moxibustion application. | Jiang Jinfeng Wang Xinjun Wu Xiaojing Yu Zhi | 2016 | Journal of Traditional Chinese Medicine2016，36，2： | 7 |
| 13 | Clinical Efficacy of Oral Ganciclovir for Prophylaxis and Treatment of Recurrent Herpes Simplex Keratitis显示文摘 | Xin Wang Linnong Wang Nianlang Wu Xinjun Ma Jianjiang Xu | 2015 | Chinese Medical Journal2015，，1： | 7 |
| 14 | Dynamic Response Analysis of Bird Strike on Aircraft Windshield Based on Damage-modified Nonlinear Viscoelastic Constitutive Relation显示文摘Damage-modified nonlinear viscoelastic constitutive equation and failure criterion are introduced and the three-dimensional incremental forms are deduced based on the updated Lagrangian approach. A simple tensile test model and a split Hopkinson pressure bar model are built to verify the accuracy of the subroutine implemented within the non-linear finite element program LS-DYNA. A numerical model of bird strike on windshield is established to study the responses of windshield under three different bird velocities at three sites. The bird is represented by a cylinder with a hemisphere at each end and the contact-impact coupling algorithm is used in this study. It is found that the implemented subroutine can properly describe the mechanical behavior of polymethyl methacrylate under low and high strain rates and large deformation, and can be used validly. | Wang Xinjun Feng Zhenzhou Wang Fusheng Yue Zhufeng | 2007 | Chinese Journal of Aeronautics2007，20，6： | 7 |
| 15 | Design and experimental study of the SPKM165, a five-axis serial-parallel kinematic milling machine显示文摘A five-axis serial-parallel kinematic milling machine, the SPKM 165, is introduced. This machine consists of a three-degree of-freedom parallel module and a two-degree-of-freedom serial table. The SPKM 165 is capable of five-face machining. A discussion of the inverse kinematics of the five-axis control is provided. A dimensional synthesis procedure is presented in terms of motion/force transmissibility. Finite-element analysis was used to evaluate the stiffness of a CAD model before the machine was manufactured. Kinematic calibration was implemented to improve the accuracy of the end effector. The results of a calibration experiment are presented. The stiffness of the developed machine was then measured. Milling experiments were conducted, and the test piece showed that the developed machine has satisfactory performance. | XIE FuGui LIU XinJun ZHANG Hui WANG JinSong | 2011 | Science China(Technological Sciences)2011，54，5： | 6 |
| 16 | Optimal Design and Force Control of a Nine-Cable-Driven Parallel Mechanism for Lunar Takeoff Simulation显示文摘Traditional simulation methods are unable to meet the requirements of lunar takeo simulations, such as high force output precision, low cost, and repeated use. Considering that cable-driven parallel mechanisms have the advantages of high payload to weight ratio, potentially large workspace, and high-speed motion, these mechanisms have the potential to be used for lunar takeo simulations. Thus, this paper presents a parallel mechanism driven by nine cables. The purpose of this study is to optimize the dimensions of the cable-driven parallel mechanism to meet dynamic workspace requirements under cable tension constraints. The dynamic workspace requirements are derived from the kinematical function requests of the lunar takeo simulation equipment. Experimental design and response surface methods are adopted for building the surrogate mathematical model linking the optimal variables and the optimization indices. A set of dimensional parameters are determined by analyzing the surrogate mathematical model. The volume of the dynamic workspace increased by 46% after optimization. Besides, a force control method is proposed for calculating output vector and sinusoidal forces. A force control loop is introduced into the traditional position control loop to adjust the cable force precisely, while controlling the cable length. The e ectiveness of the proposed control method is verified through experiments. A 5% vector output accuracy and 12 Hz undulation force output can be realized. This paper proposes a cable-driven parallel mechanism which can be used for lunar takeo simulation. | Wangmin Yi Yu Zheng Weifang Wang XiaoqiangTang Xinjun Liu Fanwei Meng | 2019 | Chinese Journal of Mechanical Engineering2019，32，4： | 5 |
| 17 | Source and deposition of polycyclic aromatic hydrocarbons to Shanghai,China显示文摘Despite recent efforts to investigate the distribution and fate of polycyclic aromatic hydrocarbons (PAHs) in air, water, and soil, very little is known about their temporal change in wet deposition. As a result of increased attention to public health, a large-scale survey on the deposition flux and distribution of PAH contamination in rainwater was urgently conducted in Shanghai, China. In this study, 163 rainwater samples were collected from six sites, and 15 PAH compounds were detected by the use of a simple solid phase microextraction (SPME) technique coupled with gas chromatography-mass spectrometry. The dominant PAH species monitored were naphthalene, phenanthrene, anthracene, and fluoranthene. The concentration of total PAHs per event was between 74 and 980 ng/L, with an average value of 481 ng/L, which is at the high end of worldwide figures. The annual deposition flux of PAHs in rainwater was estimated to be 4148 kg/yr in the Shanghai area, suggesting rainfall as a major possible pathway for removing PAHs from the atmosphere. Diagnostic analysis by the ratios of An/178 and Fl/Fl+Py suggested that combustion of grass, wood, and coal was the major contributor to PAHs in the Shanghai region. Back trajectory analysis also indicated that the pollutant sources could be from the southern part of China. | Lili Yan Xiang Li Jianmin Chen Xinjun Wang Jianfei Du Lin Ma | 2012 | Journal of Environmental Sciences2012，24，1： | 4 |
| 18 | Kinetics study on leaching of rare earth and aluminum from polishing powder waste using hydrochloric acid显示文摘In this study,a novel hydrometallurgical process consisting of hydrochloric acid three-stage countercurrent leaching and solvent extraction was proposed to recover rare earth oxide(REO)from the rare earth polishing powder waste(REPPW).The effects of HCl concentration,liquid-solid ratio(L/S ratio),temperature and time on the leaching yields of rare earths(in REO)and aluminum(in Al2O3)were studied.The result shows that the leaching yields of REO and Al2O3 are 90.96%and 43.89%respectively under the optimum leaching parameters of HCl concentration=8.00 mol/L,L/S ratio=4 mL/g,leaching temperature=353 K and leaching time=180 min.Meanwhile,the leaching kinetics of REO and Al2O3 were investigated in this study.The leaching behaviors of REO and Al2O3 follow a shrinking sphere/core model and the general leaching process is controlled by the surface chemical reaction.The leaching activation energies of REO and Al2O3 are 9.86 and 13.68 kJ/mol,respectively.The leaching yield of each substance in three-stage countercurrent leaching is improved substantially compared with single-stage leaching,with a change from 90.96%to 95.38%for REO and from 43.89%to 46.22%for Al2O3,respectively.Especially,the total concentration of REO in three-stage countercurrent leaching solution is greatly increased to above 300 g/L,and the acidity of which is decreased to ca.pH=2,which is conducive to subsequent solvent extraction directly.High purity REO(99.92%)is obtained by solvent extraction separation,oxalate precipitation and calcination.The total recovery yield of REO is 85.13%. | Xitao Wu Zhijian Wang Chuping Xia Xuefeng Shi Tianzong Luo Xinjun Bao Rongli Liu Shengzhong Xie | 2020 | Journal of Rare Earths2020，38，9： | 3 |
| 19 | A stock assessment for Illex argentinus in Southwest Atlantic using an environmentally dependent surplus production model显示文摘The southern Patagonian stock(SPS) of Argentinian shortfin squid, Illex argentinus, is an economically important squid fishery in the Southwest Atlantic. Environmental conditions in the region play an important role in regulating the population dynamics of the I. argentinus population. This study develops an environmentally dependent surplus production(EDSP) model to evaluate the stock abundance of I. argentines during the period of 2000 to 2010. The environmental factors(favorable spawning habitat areas with sea surface temperature of 16–18°C) were assumed to be closely associated with carrying capacity(K) in the EDSP model. Deviance Information Criterion(DIC) values suggest that the estimated EDSP model with environmental factors fits the data better than a Schaefer surplus model without environmental factors under uniform and normal scenarios.The EDSP model estimated a maximum sustainable yield(MSY) from 351 600 t to 685 100 t and a biomass from 1 322 400 t to1 803 000 t. The fishing mortality coefficient of I. argentinus from 2000 to 2010 was smaller than the values of F_(0.1) and F_(MSY). Furthermore, the time series biomass plot of I. argentinus from 2000 to 2010 shows that the biomass of I.argentinus and this fishery were in a good state and not presently experiencing overfishing. This study suggests that the environmental conditions of the habitat should be considered within squid stock assessment and management. | WANG Jintao CHEN Xinjun Kevin W.Staples CHEN Yong | 2018 | Acta Oceanologica Sinica2018，37，2： | 3 |
| 20 | Topology optimization of thermoelastic structures using the guide-weight method显示文摘The guide-weight method is introduced to solve the topology optimization problems of thermoelastic structures in this paper.First,the solid isotropic microstructure with penalization(SIMP)with different penalty factors is selected as a material interpolation model for the thermal and mechanical fields.The general criteria of the guide-weight method is then presented.Two types of iteration formulas of the guide-weight method are applied to the topology optimization of thermoelastic structures,one of which is to minimize the mean compliance of the structure with material constraint,whereas the other one is to minimize the total weight with displacement constraint.For each type of problem,sensitivity analysis is conducted based on SIMP model.Finally,four classical 2-dimensional numerical examples and a 3-dimensional numerical example considering the thermal field are selected to perform calculation.The factors that affect the optimal topology are discussed,and the performance of the guide-weight method is tested.The results show that the guide-weight method has the advantages of simple iterative formula,fast convergence and relatively clear topology result. | LIU XinJun WANG Chao ZHOU YanHua | 2014 | Science China(Technological Sciences)2014，57，5： | 3 |
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