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| 1 | A Chromosome-Level Genome Assembly of Garlic (Allium sativum) Provides Insights into Genome Evolution and Allicin Biosynthesis显示文摘Garlic,an economically important vegetable,spice,and medicinal crop,produces highly enlarged bulbs and unique organosulfur compounds.Here,we report a chromosome-level genome assembly for garlic,with a total size of approximately 16.24 Gb,as well as the annotation of 57561 predicted protein-coding genes,making garlic the first Allium species with a sequenced genome.Analysis of this garlic genome assembly reveals a recent burst of transposable elements,explaining the substantial expansion of the garlic genome.We examined the evolution of certain genes associated with the biosynthesis of allicin and inulin neoseries-type fructans,and provided new insights into the biosynthesis of these two compounds.Furthermore,a large-scale transcriptome was produced to characterize the expression patterns of garlic genes in different tissues and at various growth stages of enlarged bulbs.The reference genome and large-scale transcriptome data generated in this study provide valuable new resources for research on garlic biology and breeding. | Xiudong Sun Siyuan Zhu Ningyang Li Yi Cheng Jing Zhao Xuguang Qiao Li Lu Shiqi Liu Yanzhou Wang Chan Liu Benping Li Wu Guo Shuang Gao Zemao Yang Fu Li Zheng Zeng Qing Tang Yupeng Pan Mengjiao Guan Jian Zhao Xiaomi ng Lu Huanwe n Meng Zhenlin Han Chun she ng Gao Wenkai Jiang Xing Zhao Shilin Tian Jianguang Su Zhihui Cheng Touming Liu | 2020 | Molecular Plant2020，13，9： | 14 |
| 2 | Broadband polarized photodetector based on p-BP/n-ReS2 heterojunction显示文摘Two-dimensional(2D) atomic crystals,such as graphene,black phosphorus(BP) and transition metal dichalcogenides(TMDCs) are attractive for use in optoelectronic devices,due to their unique crystal structures and optical absorption properties.In this study,we fabricated BP/ReS2 van der Waals(vdWs) heterojunction devices.The devices realized broadband photoresponse from visible to near infrared(NIR)(400–1800 nm) with stable and repeatable photoswitch characteristics,and the photoresponsivity reached 1.8 mA/W at 1550 nm.In addition,the polarization sensitive detection in the visible to NIR spectrum(532–1750 nm) was demonstrated,and the photodetector showed a highly polarization sensitive photocurrent with an anisotropy ratio as high as 6.44 at 1064 nm.Our study shows that van der Waals heterojunction is an effective way to realize the broadband polarization sensitive photodetection,which is of great significance to the realization and application of multi-functional devices based on 2D vdWs heterostructures. | Wenkai Zhu Xia Wei Faguang Yan Quanshan Lv Ce Hu Kaiyou Wang | 2019 | Journal of Semiconductors2019，40，9： | 6 |
| 3 | Large Room-Temperature Magnetoresistance in van der Waals Ferromagnet/Semiconductor Junctions显示文摘A magnetic tunnel junction(MTJ)is the core component in memory technologies,such as the magnetic random-access memory,magnetic sensors and programmable logic devices.In particular,MTJs based on twodimensional van der Waals(vd W)heterostructures offer unprecedented opportunities for low power consumption and miniaturization of spintronic devices.However,their operation at room temperature remains a challenge.Here,we report a large tunnel magnetoresistance(TMR)of up to 85%at room temperature(T=300 K)in vdW MTJs based on a thin(<10 nm)semiconductor spacer WSe_(2)layer embedded between two Fe_(3)GaTe_(2e)lectrodes with intrinsic above-room-temperature ferromagnetism.The TMR in the MTJ increases with decreasing temperature up to 164%at T=10 K.The demonstration of TMR in ultra-thin MTJs at room temperature opens a realistic and promising route for next-generation spintronic applications beyond the current state of the art. | Wenkai Zhu Shihong Xie Hailong Lin Gaojie Zhang Hao Wu Tiangui Hu Ziao Wang Xiaomin Zhang Jiahan Xu Yujing Wang Yuanhui Zheng Faguang Yan Jing Zhang Lixia Zhao Amalia Patanè Jia Zhang Haixin Chang Kaiyou Wang | 2022 | Chinese Physics Letters2022，39，12： | 2 |
| 4 | Melon short internode(CmSi)encodes an ERECTA-like receptor kinase regulating stem elongation through auxin signaling显示文摘Plant height is one of the most important agronomic traits that directly determines plant architecture,and compact or dwarf plants can allow for increased planting density and land utilization as well as increased lodging resistance and economic yield.At least four dwarf/semidwarf genes have been identified in different melon varieties,but none of them have been cloned,and little is known about the molecular mechanisms underlying internode elongation in melon.Here,we report map-based cloning and functional characterization of the first semidwarf gene short internode(Cmsi)in melon,which encodes an ERECTA-like receptor kinase regulating internode elongation.Spatial-temporal expression analyses revealed that CmSI exhibited high expression in the vascular bundle of the main stem during internode elongation.The expression level of CmSI was positively correlated with stem length in the different melon varieties examined.Ectopic expression of CmSI in Arabidopsis and cucumber suggested CmSI as a positive regulator of internode elongation in both species.Phytohormone quantitation and transcriptome analysis showed that the auxin content and the expression levels of a number of genes involved in the auxin signaling pathway were altered in the semidwarf mutant,including several well-known auxin transporters,such as members of the ABCB family and PINFORMED genes.A melon polar auxin transport protein CmPIN2 was identified by protein–protein interaction assay as physically interacting with CmSI to modulate auxin signaling.Thus,CmSI functions in an auxin-dependent regulatory pathway to control internode elongation in melon.Our findings revealed that the ERECTA family gene CmSI regulates stem elongation in melon through auxin signaling,which can directly affect polar auxin transport. | Sen Yang Kaige Zhang Huayu Zhu Xiaojing Zhang Wenkai Yan Nana Xu Dongming Liu Jianbin Hu Yufeng Wu Yiqun Weng Luming Yang | 2020 | Horticulture Research2020，7，1： | 2 |
| 5 | Efficacy of Danggui Buxue decoction(当归补血汤)on diabetic nephropathy-induced renal fibrosis in rats and possible mechanism显示文摘OBJECTIVE:To observe the efficacy of Danggui Buxue decoction(当归补血汤,DBD) on diabetic nephropathyinduced renal fibrosis in rats,and to study the possible mechanism.METHODS:Sixty male Goto Kakizaki(GK) rats were randomly assigned to the model group,gliquidone group,astragaloside Ⅳ group,and high-,medium-and lowdoses DBD groups.After 8 weeks,changes in body weight,blood glucose,serum creatinine,serum urea nitrogen,and total cholesterol were observed.Changes in transforming growth factor-β1(TGF-β1),Smad3,and Smad5 pathways and the expression of the fibrosisrelated proteins collagen Ⅳ(col Ⅳ),α-smooth muscle actin(α-SMA),and vimentin were assessed.The degree of renal fibrosis was observed by immunohistochemistry and Mason staining.The expression of interleukin 6(IL-6),interleukin 10(IL-10),tumor necrosis factor(TNF-α),and C-reactive protein(CRP) in the kidneys was assessed using enzyme linked immunosorbent assay.RESULTS:Our experiments showed that DBD effectively reduced blood glucose,blood urea nitrogen,and creatinine levels after 8 weeks of administration,improved renal function in diabetic rats,alleviated renal fibrosis,and reduced the renal tissue levels of IL-6,IL-10,TNF-α,and CRP.Furthermore,DBD decreased the expression of TGF-β1,Smad3,col IV,α-SMA,and vimentin in renal tissues and increased the expression of Smad5.CONCLUSIONS:DBD ameliorates diabetic renal interstitial fibrosis by modulating the TGF-β1/Smads pathway. | ZHAO Ye WANG Xian GU Ling LI Zihang ZHU Jingtian WANG Wenkai ZHANG Liang XUE Mei | 2023 | Journal of Traditional Chinese Medicine2023，43，3： | 2 |
| 6 | Quantitative evaluation of heavy metals’ pollution hazards in liquefaction residues of sewage sludge显示文摘 | Huajun Huang Xingzhong Yuan Guangming Zeng Huina Zhu Hui Li Zhifeng Liu Hongwei Jiang Lijian Leng Wenkai Bi | 2011 | Bioresource Technology2011，，22： | 2 |
| 7 | Evaluation of the Mechanisms Underlying Amino Acid and Microbiota Interactions in Intestinal Infections Using Germ-Free Animals显示文摘Intestinal infectious diseases refer to the inflammatory changes in the intestinal tract caused by pathogens(including bacteria,viruses,fungi,protozoa,or parasites)or their toxic products.A large number of microorganisms colonize the intestinal tract of healthy people,which together with the intestinal epithelium constitute the biological barrier of the intestinal tract to resist infectious diseases.As an“invisible organ,”the intestinal flora is closely related to human nutrition metabolism and intestinal infections.A variety of intestinal flora participates in the nutritional metabolism of amino acids,and the small molecular substances produced by the amino acid metabolism through the intestinal flora can enhance intestinal immunity and resist bacterial infections.In turn,amino acids can also regulate the composition of the intestinal flora,maintain the steady-state of the intestinal flora,protect the intestinal barrier,and inhibit colonization by pathogenic bacteria.As a model animal with a clear microbial background,germ-free(GF)animals can clarify the mechanisms of interactions between intestinal microbes and amino acid metabolism in intestinal infections by combining genetic engineering technology and multi-omics studies.This article reviews related researches on the involvement of intestinal microbes in host amino acid metabolism and resistance to intestinal infections and discusses the advantages of GF animal models for studying the underlying mechanisms.The GF animal model is helpful to further study the intervention effects of amino acid metabolism of targeted intestinal flora on intestinal infections. | Yapeng Yang Peng Bin Shiyu Tao Guoqiang Zhu Zhifeng Wu Wei Cheng Wenkai Ren Hong Wei | 2021 | Infectious Microbes & Diseases2021，3，2： | 1 |
| 8 | A small microring array that performs large complex-valued matrix-vector multiplication显示文摘As an important computing operation,photonic matrix-vector multiplication is widely used in photonic neutral networks and signal processing.However,conventional incoherent matrix-vector multiplication focuses on real-valued operations,which cannot work well in complex-valued neural networks and discrete Fourier transform.In this paper,we propose a systematic solution to extend the matrix computation of microring arrays from the real-valued field to the complex-valued field,and from small-scale(i.e.,4×4)to large-scale matrix computation(i.e.,16×16).Combining matrix decomposition and matrix partition,our photonic complex matrix-vector multiplier chip can support arbitrary large-scale and complex-valued matrix computation.We further demonstrate Walsh-Hardmard transform,discrete cosine transform,discrete Fourier transform,and image convolutional processing.Our scheme provides a path towards breaking the limits of complex-valued computing accelerator in conventional incoherent optical architecture.More importantly,our results reveal that an integrated photonic platform is of huge potential for large-scale,complex-valued,artificial intelligence computing and signal processing. | Junwei Cheng Yuhe Zhao Wenkai Zhang Hailong Zhou Dongmei Huang Qing Zhu Yuhao Guo Bo Xu Jianji Dong Xinliang Zhang | 2022 | Frontiers of Optoelectronics2022，15，2： | 1 |
| 9 | Securing Collaborative Spectrum Sensing against Untrustworthy Secondary Users in Cognitive Radio Networks显示文摘 | Wenkai Wang Husheng Li Yan(Lindsay)Sun Zhu Han | 2010 | EURASIP Journal on Advances in Signa l Processing2010，，： | 1 |
| 10 | Targeting the Central Histamine H, Receptor: New Hope for Schizophrenia?显示文摘Histamine is a neurotransmitter and neuromodulator in the central nervous system,which plays its function through binding with diferent histamine receptors,such as H_(1)receptor(H_(1)R),H_(2)receptor(H_(2)R),H_(3)receptor(H_(3)R),and H_(4)receptor(H_(4)R)[1,2].Although both H_(1)R and H_(2)R,as post-synaptic receptors,are expressed in most brain areas,they captured different attention from scientists.H,R is well stud-ied and believed to play critical roles in many physiological and pathological processes,including sleep and wakefulness. | Wenkai Lin Xuemin Yu Xinyan Zhu | 2024 | Neuroscience Bulletin2024，40，1： | 0 |
| 11 | Highly Stretchable Ionic and Electronic Conductive Fabric显示文摘Wearable devices redefine the way people interact with machines.Despite the intensive effort in the design and fabrication of synthetic fibers to improve wearable device properties in terms of electronic and ionic conductivity,stretchability,com-fort,and washability,challenges remain in fabricating single fiber materials that optimize all properties simultaneously.In this work,we demonstrate a highly stretchable,ionic,and electronic conductive fabric via(1)the natural nanoscale chan-nels in fibers for effective ion transportation,(2)confining the electronic conductive material with the cellulose fibers,and(3)decoupling the property degradation of the fiber from deformation using the knitted pattern.The hierarchical structure created by cotton fibers can serve as ionic conductive channels as well as a robust multiscale scaffold to host infiltrated elec-tronic conductive materials.Cotton strands with ionic and electronic conductivity can be knitted into fabrics that are highly stretchable(~300%).Moreover,high ionic and electronic conductivity are observed with 2 S/m and 5 S/m,respectively,even under a strain of 175%.With the inherent advantages of cotton fabrics such as moisture-wicking,washability,comfort,and light-weightiness for wearable applications,our approach of directly functionalized cellulose can potentially be a promising route towards highly stretchable and wearable mixed conductors. | Pengfei Deng Xuan Li Yanbin Wang Zijian He Wenkai Zhu Yun Zhang Gabriella M.Schalm Tian Li | 2023 | Advanced Fiber Materials2023，5，1： | 0 |
| 12 | Design Rules of the Mixing Phase and Impacts on Device Performance in High-Efficiency Organic Photovoltaics显示文摘In nonfullerene acceptor-(NFA-)based solar cells,the exciton splitting takes place at both domain interface and donor/acceptor mixture,which brings in the state of mixing phase into focus.The energetics and morphology are key parameters dictating the charge generation,diffusion,and recombination.It is revealed that tailoringthe electronic properties of the mixing region by doping with larger-bandgap components could reduce the density of state but elevate the filling state level,leading to improved open-circuit voltage(V_(OC))and reduced recombination.The monomolecular and bimolecular recombinations are shown to be intercorrelated,which show a Gaussian-like relationship with V_(OC) and linear relationship with short-circuit current density(JSC)and fill factor(FF).The kinetics of hole transfer and exciton diffusion scale with JSC similarly,indicating the carrier generation in mixing region and crystalline domain are equally important.From the morphology perspective,the crystalline order could contribute to V_(OC) improvement,and the fibrillar structure strongly affects the FF.These observations highlight the importance of the mixing region and its connection with crystalline domains and point out the design rules to optimize the mixing phase structure,which is an effective approach to further improve device performance. | Jingnan Song Ming Zhang Tianyu Hao Jun Yan Lei Zhu Guanqing Zhou Rui Zeng Wenkai Zhong Jinqiu Xu Zichun Zhou Xiaonan Xue Chun-Chao Chen Weihua Tang Haiming Zhu Zaifei Ma Zheng Tang Yongming Zhang Feng Liu | 2022 | Research2022，，4： | 0 |
| 13 | Melatonin inhibits Gram-negative pathogens by targeting citrate synthase显示文摘Bacterial infections caused by Gram-negative pathogens represent a growing burden for public health worldwide.Despite the urgent need for new antibiotics that effectively fight against pathogenic bacteria,very few compounds are currently under development or approved in the clinical setting.Repurposing compounds for other uses offers a productive strategy for the development of new antibiotics.Here we report that the multifaceted melatonin effectively improves survival rates of mice and decreases bacterial loads in the lung during infection.Mechanistically,melatonin specifically inhibits the activity of citrate synthase of Gram-negative pathogens through directly binding to the R300,D363,and H265 sites,particularly for the notorious Pasteurella multocida.These findings highlight that usage of melatonin is a feasible and alternative therapy to tackle the increasing threat of Gram-negative pathogen infections via disrupting metabolic flux of bacteria. | Fang He Yuan Liu Pan Li Xiaoyan Wu Yaoyao Xia Dong Zhang Nengzhang Li Yuanyi Peng Guoqiang Zhu Rüdiger Hardeland Russel JReiter Wenkai Ren | 2022 | Science China(Life Sciences)2022，65，7： | 0 |
| 14 | Deterioration Mechanism of Concrete Subjected to Acid Rain Attack——An Experimental and Modeling Approach显示文摘The experimental and modeling approaches were taken to study the deterioration mechanism of concrete under acid rain attack.Concrete specimens were prepared and exposed to the simulated acid rain environment.The neutralization depth of concrete was measured,and the mineralogical composition and microstructure of concrete were analyzed using X-ray diffraction (XRD) and scanning electron microscope (SEM).The experimental results show that the degradation of concrete increases with the corrosion time and the decrease in pH value of acidic solution from 3.5 to 1.5.Concrete was corroded by H~+ and SO_4^(2-)in acid rain,producing gypsum and leading to the neutralization of concrete.The acid rain exposure also resulted in the decomposition of hydration products of cement,such as C-S-H and ettringite,forming the main corrosion products of gypsum and SiO_(2)·nH_(2)O.Based on the second Fick diffusion law,a model was developed to describe the deterioration mechanism of concrete exposed to acid rain mathematically,coupling the diffusion of reactive ions and the corrosion reaction.The simulation results and the experimental results were compared and discussed. | 李北星 YUAN Xiaolu ZHANG Yaming ZHU Wenkai | 2022 | Journal of Wuhan University of Technology(Materials Science)2022，37，5： | 0 |
| 15 | Gut microbiota bridges dietary nutrients and host immunity显示文摘Dietary nutrients and the gut microbiota are increasingly recognized to cross-regulate and entrain each other,and thus affect host health and immune-mediated diseases.Here,we systematically review the current understanding linking dietary nutrients to gut microbiota-host immune interactions,emphasizing how this axis might influence host immunity in health and diseases.Of relevance,we highlight that the implications of gut microbiota-targeted dietary intervention could be harnessed in orchestrating a spectrum of immune-associated diseases. | Lijuan Fan Yaoyao Xia Youxia Wang Dandan Han Yanli Liu Jiahuan Li Jie Fu Leli Wang Zhending Gan Bingnan Liu Jian Fu Congrui Zhu Zhenhua Wu Jinbiao Zhao Hui Han Hao Wu Yiwen He Yulong Tang Qingzhuo Zhang Yibin Wang Fan Zhang Xin Zong Jie Yin Xihong Zhou Xiaojun Yang Junjun Wang Yulong Yin Wenkai Ren | 2023 | Science China(Life Sciences)2023，66，11： | 0 |
| 16 | Optimizing the morphology of all-polymer solar cells for enhanced photovoltaic performance and thermal stability显示文摘Due to the complicated film formation kinetics, morphology control remains a major challenge for the development of efficient and stable all-polymer solar cells(all-PSCs). To overcome this obstacle, the sequential deposition method is used to fabricate the photoactive layers of all-PSCs comprising a polymer donor PTzBI-oF and a polymer acceptor PS1. The film morphology can be manipulated by incorporating amounts of a dibenzyl ether additive into the PS1 layer. Detailed morphology investigations by grazing incidence wide-angle X-ray scattering and a transmission electron microscope reveal that the combination merits of sequential deposition and DBE additive can render favorable crystalline properties as well as phase separation for PTzBI-oF:PS1 blends. Consequently, the optimized all-PSCs delivered an enhanced power conversion efficiency(PCE) of 15.21%along with improved carrier extraction and suppressed charge recombination. More importantly, the optimized all-PSCs remain over 90% of their initial PCEs under continuous thermal stress at 65 °C for over 500 h. This work validates that control over microstructure morphology via a sequential deposition process is a promising strategy for fabricating highly efficient and stable all-PSCs. | Kang An Wenkai Zhong Chunguang Zhu Feng Peng Lei Xu Zhiwei Lin Lei Wang Cheng Zhou Lei Ying Ning Li Fei Huang | 2023 | Journal of Semiconductors2023，44，5： | 0 |
| 17 | Notes on the hypersonic boundary layer transition显示文摘A brief discussion is given in this note to clarify the transition path of the hypersonic boundary layer.The first mode plays an important role in the hypersonic boundary layer transition and should not be ignored.The second mode may enhance the boundary layer transition,but it is not the decisive factor affecting the transition. | Wenkai Zhu | 2022 | Advances in Aerodynamics2022，4，1： | 0 |
| 18 | Generation of acoustic waves in the hypersonic boundary layer over a wavy wall显示文摘The effects of a wavy wall on a hypersonic boundary layer of a flared cone are investigated using experimental measurements and direct numerical simulations(DNSs). Non-contact optical measurements using a focused laser differential interferometer(FLDI) show that a wavy wall can significantly suppress the second mode, and multiple perturbations of new frequencies are generated over the wavy surface, which agrees well with numerical results. Using Lagrangian tracking of marked particles, it is demonstrated that the wavy wall geometry can induce mean flow oscillations while exciting acoustic waves. The frequencies of the excited disturbances over a wavy wall agree with the classical Rossiter model. The superposition of a disturbance propagating downstream and an acoustic wave propagating upstream at the same frequency but with different amplitudes and propagation velocities results in a spatial distribution with a streamwise-oscillatory pattern over the wavy surface. A simple two-wave superposition model that takes into account the phase velocities and wavenumbers of the convective disturbance and acoustic wave can well describe the modal behavior of excited disturbances over a wavy wall. | WenKai Zhu DingWei Gu YiDing Zhu CunBiao Lee | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，3： | 0 |
| 19 | The structure-performance correlation of bulk-heterojunction organic solar cells with multi-length-scale morphology显示文摘We build a general multi-length-scale morphology model with mixing phase and pure phase fibril structure,and simulate corresponding organic solar cells performance.Systematical multi-length-scale morphology optimization process by changing the proportion of mixing phase and pure phase in different period width cases shows a clear correlation between period width and device performance that a smaller period width with appropriate proportion of mixing phase and fibril structure is advantageous to achieve high-performance devices.Experiments on multiple donor/acceptor blends have been carried out by varying the composition and processing condition,which afford good structure-performance correlation that supports the model prediction.It is demonstrated that building such a multi-length-scale morphology merging the synergistic effects of mixing and pure phases is indeed an imperative avenue to improve device efficiency. | Tianyu Hao Wenkai Zhong Shifeng Leng Rui Zeng Ming Zhang Lei Zhu Yankang Yang Jingnan Song Jinqiu Xu Guanqing Zhou Yecheng Zou Yongming Zhang Feng Liu | 2022 | Science China Chemistry2022，65，8： | 0 |
| 20 | Optical engineering of infrared PbS CQD photovoltaic cells for wireless optical power transfer systems显示文摘Infrared photovoltaic cells(IRPCs)have attracted considerable attention for potential applications in wireless optical power transfer(WOPT)systems.As an efcient fber-integrated WOPT system typically uses a 1550 nm laser beam,it is essential to tune the peak conversion efciency of IRPCs to this wavelength.However,IRPCs based on lead sulfde(PbS)colloidal quantum dots(CQDs)with an excitonic peak of 1550 nm exhibit low short circuit current(Jsc)due to insufcient absorption under monochromatic light illumination.Here,we propose comprehensive optical engineering to optimize the device structure of IRPCs based on PbS CQDs,for 1550 nm WOPT systems.The absorption by the device is enhanced by improving the transmittance of tin-doped indium oxide(ITO)in the infrared region and by utilizing the optical resonance efect in the device.Therefore,the optimized device exhibited a high short circuit current density of 37.65 mA/cm^(2)under 1 sun(AM 1.5G)solar illumination and 11.91 mA/cm^(2)under 1550 nm illumination 17.3 mW/cm^(2).Furthermore,the champion device achieved a record high power conversion efciency(PCE)of 7.17%under 1 sun illumination and 10.29%under 1550 nm illumination.The PbS CQDs IRPCs under 1550 nm illumination can even light up a liquid crystal display(LCD),demonstrating application prospects in the future. | Mengqiong Zhu Yuanbo Zhang Shuaicheng Lu Zijun Wang Junbing Zhou Wenkai Ma Ruinan Zhu Guanyuan Chen Jianbing Zhang Liang Gao Jiancan Yu Pingqi Gao Jiang Tang | 2023 | Frontiers of Optoelectronics2023，16，2： | 0 |
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