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| 1 | Correction of a genetic disease by CRISPR-Cas9-mediated gene editing in mouse spermatogonial stem cells显示文摘Spermatogonial 干细胞(SSC ) 能在移植以后生产众多的男配偶子进接受者睾丸,介绍为基因治疗和修改基因的动物的连续生产的一条珍贵途径。然而, SSC 的成功的基因操作被限制了,部分由于复杂性和当前可得到的基因编辑技术的低效率。这里,我们证明有效基因修正能用 CRISPR-Cas9 系统被介绍进 SSC。我们使用了 CRISPR-Cas9 系统变异在 SCC 的 EGFP transgene 或内长的 Crygc 基因。变异的 SSC 在移植以后经历了精子发生进不肥沃的老鼠睾丸的生精的小管。圆 spermatids 被产生并且在进成熟卵母细胞的注射以后,支持了显示相应变异的显型的异质接合的后代的生产。而且,在 Crygc 的一个引起疾病的变化(在 SSC 先存在的 Crygc −/−) 能乐意地到加入的 CRISPR-Cas9-induced nonhomologous 结束(NHEJ ) 或指导相同的修理(HDR ) 被修理,导致没有是的离开目标修正的证据带改正的基因的 SSC 线由整个染色体的定序出现。用从这些线产生的圆 spermatids 的授精在 100% 的效率与改正的显型产生了后代。我们的结果表明有效基因由 CRISPR-Cas9 系统在老鼠 SSC 编辑,并且提供在 SSC 经由基因修正治好基因疾病的原则的证明。 | Yuxuan Wu Hai Zhou Xiaoying Fan Ying Zhang Man Zhang Yinghua Wang Zhenfei Xie Meizhu Bai Qi Yin Dan Liang Wei Tang Jiaoyang Liao Chikai Zhou Wujuan Liu Ping Zhu Hongshan Guo Hong Pan Chunlian Wu Huijuan Shi Ligang Wu Fuchou Tang Jinsong Li | 2015 | Cell Research2015，25，1： | 37 |
| 2 | BMP2 and VEGF promote angiogenesis but retard terminal differentiation of osteoblasts in bone regeneration by up-regulating Idl显示文摘不适当的 vascularization 限制骨头缺点的修理。以便改进 angiogenesis 并且加速成骨,有在骨头新生的基因修正的 co 有教养的房间的协同在这研究被调查。Endothelial 祖先房间(EPC ) 和骨头髓干细胞(BMSC ) 是有脉管的 endothelial 生长因素(VEGF ) 和骨头的基因的 transfected 形态基因的蛋白质 2 (BMP2 ) 由侵入人体气管粘膜的病菌分别地。co 有教养的房间,包括 BMSC + EPC, Ad-BMP2BMSC + EPC, BMSC + Ad-VEGFEPC,和 Ad-BMP2BMSC + 指定 Ad-VEGFEPC 组织为四个组,在 alginate 胶化上被播种然后肌内地植入进老鼠在 angiogenesis 和成骨上评估效果。VEGF 和 BMP2 能导致禁止者的 overexpression DNA 有约束力 1 (Id1 ) 显著地在 vitro 和增加支持了试管形成的基因在在培植以后的 Ad-BMP2BMSC + Ad-VEGFEPC 组的血容器的数量。不过, Id1 的 overexpression 延迟了造骨细胞和骨头形成的终端区别。后来,在 transcriptional 水平,钙小瘤,和碱的磷酸酶(高山) 活动的 osteogenic 基因表示证明渐渐的减少和最新形成的成骨区域的数量在 Ad-BMP2BMSC + Ad-VEGFEPC 组展出了小增加。这发现建议在 VEGFEPC 和 BMP2BMSCs 的 Id1 表示的一条平衡规定可能对为骨头新生的基于房间、基于基因的途径批评。 | Xiaobin Song Shaohua Liu Xun Qu Yingwei Hu Xiaoying Zhang Tao Wang Fengcai Wei | 2011 | Acta Biochimica et Biophysica Sinica2011，43，10： | 13 |
| 3 | Spatial transcriptomic survey of human embryonic cerebral cortex by single-cell RNA-seq analysis显示文摘人的大脑开发的细胞的复杂性强烈地被调查了,尽管全部人的服的外皮的地区性的描述没基于单个房间的 transcriptome 分析被报导。这里,我们从人的中间怀孕期的胚胎的 22 个大脑区域在超过 4,000 个单个房间上执行了 RNA-seq。我们识别了 29 房间亚簇,它证明在每个区域和脑桥的不同比例显示出星形细胞的特别高的百分比。胚胎的神经原不象成年神经原一样多样,尽管他们在成年人拥有了他们的命运的重要特征。神经原开发是在服的外皮的 unsynchronized,当背面的区域看起来比在这个阶段的腹的区域更成熟。区域特定的基因包括地在每 neuronal 亚簇被识别,并且这些基因的一个大比例是联系的神经疾病。我们的结果介绍区域化的基因表示的一处系统的风景和人的服的外皮的神经原成熟。 | Xiaoying Fan Ji Dong Suijuan Zhong Yuan Wei Qian Wu Liying Yan Jun Yong Le Sun Xiaoye Wang Yangyu Zhao Wei Wang Jie Yan Xiaoqun Wang Jie Qiao Fuchou Tang | 2018 | Cell Research2018，28，7： | 11 |
| 4 | Pretreatment with scutellaria baicalensis stem-leaf total flavonoid prevents cerebral ischemia-reperfusion injury显示文摘Pretreatment with scutellaria baicalensis stem-leaf total flavonoid has protective effects against ischemia and attenuates myocardial ischemia-reperfusion injury.In this study,rats were given scutellaria baicalensis stem-leaf total flavonoid intragastrically at 50,100,and 200 mg/kg per day for7 days before focal cerebral ischemia-reperfusion injury models were established using the suture method.We then determined the protective effects of scutellaria baicalensis stem-leaf tota flavonoid pretreatment on focal cerebral ischemia-reperfusion injury.Results showed that neurological deficit scores increased,infarct volumes enlarged,apoptosis increased and Bcl-2 and Bax protein expression were upregulated at 24 hours after reperfusion.Pretreatment with scutellaria baicalensis stem-leaf total flavonoid at any dose lowered the neurological deficit scores reduced the infarct volume,prevented apoptosis in hippocampal cells,attenuated neuronal and blood-brain barrier damage and upregulated Bcl-2 protein expression but inhibited Bax protein expression.Doses of 100 and 200 mg/kg were the most efficacious.Our findings indicate that pretreatment with scutellaria baicalensis stem-leaf total flavonoid at 100 and 200 mg/kg can improve the neurological functions and have preventive and protective roles after focal cerebra ischemia-reperfusion injury. | Shumin Zhao Wei Kong Shufeng Zhang Meng Chen Xiaoying Zheng Xiangyu Kong | 2013 | Neural Regeneration Research2013，8，34： | 11 |
| 5 | DNA methylation and chromatin accessibility profiling of mouse and human fetal germ cells显示文摘染色质改变为人的初发的细菌房间的 epigenetic reprogramming 是重要的。然而,全面染色质状态还没为人的胎儿的细菌房间(FGC ) 被分析了。这里,我们使用 nucleosome 占有和 methylation 定序方法在人和老鼠在胎儿的细菌房间开发期间在一系列关键时间点分析染色体宽的染色质可接近性和 DNA methylome。我们在人和老鼠 FGC 发现 116 887 和 137 557 个弄空 nucleosome 的区域(NDR ) ,盖住 germline 特定、高度有活力的规章的 genomic 元素的一个大集合,例如 enhancers。而且,我们发现远侧的 NDR 在人的 FGC 为象 NANOG , SOX17 , AP2 和 OCT4 那样的 pluripotency 和细菌房间主人管理者的有约束力的主题明确地被充实,显示在pluripotency相关的基因和细菌之间的精细的规章的平衡的存在在人的 FGC 的房间特定的基因,并且为在 vivo 的细菌房间开发的这些基因的功能的意义。我们的工作为把提供一张全面、高分辨率的路线图染色质状态转变动力学在人和老鼠 FGC 的 epigenomic reprogramming 期间。 | Hongshan Guo Boqiang Hu Liying Yan Jun Yong Yan Wu Yun Gao Fan Guo Yu Hou Xiaoying Fan Ji Dong Xiaoye Wang Xiaohui Zhu Jie Yan Yuan Wei Hongyan Jin Wenxin Zhang Lu Wen FuchouTang Jie Qiao | 2017 | Cell Research2017，27，2： | 9 |
| 6 | The Pengguan tectonic dome of Longmen Mountains, Sichuan Province:Mesozoic denudation of a Neoproterozoic magmatic arc-basin system显示文摘Neoproterozoic igneous and metamorphic complexes occur as tectonic domes in the Longmen Mountains of the western margin of the Yangtze Block, and are important in reconstructing the Rodinian supercontinent and constraining the timing and mechanism of tectonic denudational processes. The Pengguan dome consists of granitic intrusions and metamorphic rocks of the Huangshuihe Group and is tectonically overlain by ductilly deformed Sinian to Paleozoic strata. The plutonic intrusions consist of granites with abundant amphibolite enclaves. New LA-ICP-MS zircon U-Pb dating yielded an emplacement age of 809±3 Ma and a protolith age of 844±6 Ma for the granite. The granitic rocks have geochemical signatures typical of A-type granites, indicating their formation under an extensional environment, by melting of newly formed tonalite-trondhjemite-granodiorite (TTG) rocks. A detachment fault, characterized by variable ductile shear deformation of S-C fabric and ESE-ward kinematics, separates the Pengguan dome from the Sinian-Paleozoic cover. 40Ar/39Ar dating of muscovite from the mylonite in the detachment fault of the dome demonstrates that ductile deformation occurred at ~160 Ma. This study indicates the existence of a Neoproterozoic magmatic arc-basin system, which was denudated by a Jurassic middle crustal ductile channel flow along the Longmenshan thrust belt. | YAN DanPing ZHOU MeiFu WEI GuoQing GAO JianFeng LIU ShaoFeng XU Ping SHI XiaoYing | 2008 | Science China Earth Sciences2008，51，11： | 9 |
| 7 | Allele-defined genome reveals biallelic differentiation during cassava evolution显示文摘Dear Editor,Generation of heterozygous genomes by hybridization between or within species can help maintain plant diversity and serve as a potential source of new species(Baek et al.,2018).Moreover,genomic heterozygosity is associated with genomic coadaptation,developmental stability,and heterosis.Accurate definition of alleles in haplotypes is necessary to precisely characterize allelic variation controlling agriculturally important traits(Shi et al.,2019).Currently,most released genomes have mosaic assembly of haplotypes due to random selection or collapse of alleles during genome assembly(Shi et al.,2019),which masked allelic variation and functional differentiation of divergent alleles in heterozygous species. | Wei Hu Changmian Ji Haitao shi Zhe Liang Zehong Ding Jianqiu Ye Wenjun Ou Gang Zhou Weiwei Tie Yan Yan Jinghao Yang Xiaoying Yang Yunxie Wei Zhiqiang Jin Jianghui Xie Ming Peng Wenquan Wang Anping Guo Biyu Xu Jianchun Guo Songbi Chen Liming Ma Mingcheng Wang Yang Zhou Xiaolong Li Ruoxi Li Siyi Guo Xinhui Xiao Zhongqing Wan Feifei An Jie Zhang Qingyun Leng Yin Li Ray Ming Kaimian Li | 2021 | Molecular Plant2021，14，6： | 8 |
| 8 | Pretreatment with scutellaria baicalensis stem-leaf total flavonoid protects against cerebral ischemia/reperfusion injury in hippocampal neurons显示文摘Previous experimental studies have shown that cerebral infarction can be effectively reduced following treatment with scutellaria baicalensis stem-leaf total flavonoid(SSTF). However, the mechanism of action of SSTF as a preventive drug to treat cerebral infarction remains unclear. In this study, Sprague-Dawley rats were pretreated with 50, 100, 200 mg/kg SSTF via intragastric administration for 1 week prior to the establishment of focal cerebral ischemia/reperfusion injury. The results showed that pretreatment with SSTF effectively improved neurological function, reduced brain water content and the permeability of blood vessels, ameliorated ischemia-induced morphology changes in hippocampal microvessels, down-regulated Fas and Fas L protein expression, elevated the activity of superoxide dismutase and glutathione peroxidase, and decreased malondialdehyde content. In contrast to low-dose SSTF pretreatment, the above changes were most obvious after pretreatment with moderate- and high-doses of SSTF. Experimental findings indicate that SSTF pretreatment can exert protective effects on the brain against cerebral ischemia/reperfusion injury. The underlying mechanisms may involve reducing brain water content, increasing microvascular recanalization, inhibiting the apoptosis of hippocampal neurons, and attenuating free radical damage. | Xiangyu Kong Wei Kong Guangxin Miao Shumin Zhao Meng Chen Xiaoying Zheng Jiangtao Bai | 2014 | Neural Regeneration Research2014，9，23： | 7 |
| 9 | An antiretroviral regimen containing 6 months of stavudine followed by long-term zidovudine for first-fine HIV therapy is optimal in resource-limited settings: a prospective, multicenter study in China显示文摘 | Li Taisheng Guo Fuping Li Yijia Zhang Chengda Han Yang Lye Wei He Yun Lu Hongzhou Xie Jing Huang Aiqiong Li Yanling Tang Xiaoping Wang Hui Zhang Tong Gao Guiju Lei Junkang Zhang Xiaoying Wu Xinhua Sun Yongtao Bai Jinsong Luo Ling Wang Huanlmg | 2014 | Chinese Medical Journal2014，，1： | 6 |
| 10 | Research and implementation of the monitor for in situ radioactivity measurements in the marine environment显示文摘As the traditional methods can not meet the requirements of marine radioactivity monitoring,a radioactivity monitoring sensor used in marine field has been proposed.This sensor is based on Nal(TI) scintillation crystal and employs the special shielding method,the anticoincidence design,the spectrum stabilization algorithm of characteristic peaks and the Monte Carlo simulation fitting calibration formula.Through the continuous tests of terminals and the activity test for target nuclide ^(40)K,it is found that the sensor is stable and the error is less than 10%. | REN Guoxing WEI Zhiqiang WANG Xiaoying ZHANG Yingying ZHANG Guohua | 2015 | Instrumentation2015，2，2： | 6 |
| 11 | Expert consensus on regenerative endodontic procedures显示文摘Regenerative endodontic procedures(REPs)is a biologic-based treatment modality for immature permanent teeth diagnosed with pulp necrosis.The ultimate objective of REPs is to regenerate the pulp-dentin complex,extend the tooth longevity and restore the normal function.Scientific evidence has demonstrated the efficacy of REPs in promotion of root development through case reports,case series,cohort studies,and randomized controlled studies.However,variations in clinical protocols for REPs exist due to the empirical nature of the original protocols and rapid advancements in the research field of regenerative endodontics.The heterogeneity in protocols may cause confusion among dental practitioners,thus guidelines and considerations of REPs should be explicated.This expert consensus mainly discusses the biological foundation,the available clinical protocols and current status of REPs in treating immature teeth with pulp necrosis,as well as the main complications of this treatment,aiming at refining the clinical management of REPs in accordance with the progress of basic researches and clinical studies,suggesting REPs may become a more consistently evidence-based option in dental treatment. | Xi Wei Maobin Yang Lin Yue Dingming Huang Xuedong Zhou Xiaoyan Wang Qi Zhang Lihong Qiu Zhengwei Huang Hanguo Wang Liuyan Meng Hong Li Wenxia Chen Xiaoying Zou Junqi Ling | 2022 | International Journal of Oral Science2022，14，4： | 5 |
| 12 | Evodiamine induces extrinsic and intrinsic apoptosis of ovarian cancer cells via the mitogen-activated protein kinase/phosphatidylinositol-3-kinase/protein kinase B signaling pathways显示文摘OBJECTIVE: To explore the effects of evodiamine on ovarian cancer cells and the mechanisms underlying such effects.METHODS: Human ovarian cancer cells HO-8910 PM were treated with evodiamine at 0, 1.25,2.5, and 5 μM for 1-4 d. 3-(4,5-Dimethiylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) assay was used to detect the growth inhibition rate of evodiamine-treated HO-8910 PM cells. The cell cycle was observed via propidium iodide(PI) staining. Apoptosis induction was assessed via Annexin V-fluorescein isothiocyanate/propidium iodide(Annexin V-FITC/PI) double staining assay. To verify the mechanism of apoptosis, caspase-dependent apoptotic pathway-related protein was detected by Western blot analysis. The expression levels of mitogen-activated protein kinase(MAPK)and/or phosphatidylinositol-3-kinase(PI3K)/pro-tein kinase B(Akt) pathway-related proteins were also investigated.RESULTS: Evodiamine significantly inhibited the proliferation of HO-8910 PM cells in a dose- and time-dependent manner. Evodiamine induced G2/M arrest with an increase of cyclin B1 level, and promoted cell apoptosis with a decrease of B cell lymphoma/lewkmia-2(Bcl-2) and an increase of Bcl-2-associated X protein(Bax) level. In addition,evodiamine treatment led to the activation of caspase-8, caspase-9, and caspase-3 and the cleavage of poly(ADP-ribose)-polymerase(PARP). Evodiamine targeted the MAPK and/or PI3K/Akt pathways by reducing the expression and activity of PI3 K, Akt, and extracellular signal-regulated kinase mitogen-activated protein kinase(ERK1/2 MAPK)and the activity of p38 MAPK.CONCLUSION: Evodiamine can inhibit the growth of ovarian cancer cells by G2/M arrest and intrinsic and extrinsic apoptosis. In addition, evodiamine-induced PI3K/Akt, ERK1/2 MAPK, and p38 MAPK signaling may be involved in cell death. | Wei Lijuan Jin Xiaoying Cao Zipei Li Wenlu | 2016 | Journal of Traditional Chinese Medicine2016，36，3： | 5 |
| 13 | 胃食管反流病:内镜评估与治疗方面的革新显示文摘内镜技术的创新为胃食管反流病(GERD)的诊治带来了巨大进步。作为世界上最常见的胃肠疾病之一,GERD一直是内镜介入治疗的前沿。目前,GERD的初步诊断是基于症状和质子泵抑制剂(PPI)初期治疗有效,但这对治疗策略的指导价值有限。然而,内镜检查和病理活检可直接观察和判断食管的异常结构和病理生理损伤;同时,内镜治疗的出现给PPI治疗依从性较差或治疗反应不佳以及不适合行胃底折叠抗反流手术的患者提供了新的治疗选择。本综述对内镜检查和活检在经过恰当的抗反流药物治疗后持续存在GERD相关临床表现的患者中的应用情况进行了概述,并介绍了目前内镜治疗GERD的各项新技术及其优缺点。今后的研究需要对GERD患者进行分层研究,并力图阐明该疾病的主要病理生理机制。 | Sheng Chen Feng Du Changqing Zhong Caifang Liu Xiaoying Wang Yan Chen Gang Wang Xiaopei Gao Lu Zhang Lianyong Li Wei Wu | 2021 | Gastroenterology Report2021，9，5： | 4 |
| 14 | Altered small-world,functional brain networks in patients with lower back pain显示文摘In this study, we aimed to investigate the functional network changes that occur in patients with lower back pain(LBP). We also investigated the link between LBP and the small-world properties of functional networks within the brain. Functional MRI(fMRI) was performed on 20 individuals with LBP and 17 age and gender-matched normal controls during the resting state. The severity of the pain in the individuals with LBP ranged from 5 to 8 on a 0–10 scale, with 0 indicating no pain. Network-based statistics were performed to investigate the differences between the brain networks of individuals with LBP and those of normal controls. Several small-world parameters of brain networks were calculated, including the clustering coefficient, characteristic path length, local efficiency, and global efficiency. These criteria reflect the overall network efficiency. The brain networks in the individuals with LBP due to herniation of a lumbar disc demonstrated a significantly longer characteristic path length as well as a lower clustering coefficient, global efficiency, and local efficiency compared to those in control subjects. We found that LBP patients tended to have unstable and inefficient brain networks when compared with healthy controls. In addition, LBP individuals showed significantly decreased functional connectivity in the anterior cingulate cortex, middle cingulate cortex, post cingulate cortex, inferior frontal gyrus, middle temporal gyrus, occipital gyrus, postcentral gyrus, precentral gyrus, supplementary motor area, thalamus, fusiform, caudate, and cerebellum. We believe that these regions may be involved in the pathophysiology of lower back pain. | Jing Liu Feng zhang Xiufen Liu Zhizheng Zhuo Juan Wei Minyi Du Queenie Chan Xiaoying Wang Dongxin Wang | 2018 | Science China(Life Sciences)2018，61，11： | 4 |
| 15 | Symptom network topological features predict the effectiveness of herbal treatment for pediatric cough显示文摘Pediatric cough is a heterogeneous condition in terms of symptoms and the underlying disease mechanisms.Symptom phenotypes hold complicated interactions between each other to form an intricate network structure.This study aims to investigate whether the network structure of pediatric cough symptoms is associated with the prognosis and outcome of patients.A total of 384 cases were derived from the electronic medical records of a highly experienced traditional Chinese medicine (TCM) physician.The data were divided into two groups according to the therapeutic effect,namely,an invalid group (group A with 40 cases of poor efficacy) and a valid group (group B with 344 cases of good efficacy).Several well-established analysis methods,namely,statistical test,correlation analysis,and complex network analysis,were used to analyze the data.This study reports that symptom networks of patients with pediatric cough are related to the effectiveness of treatment: a dense network of symptoms is associated with great difficulty in treatment.Interventions with the most different symptoms in the symptom network may have improved therapeutic effects. | Mengxue Huang Jingjing Wang Runshun Zhang Zhuying Ni Xiaoying Liu Wenwen Liu Weilian Kong Yao Chen Tiantian Huang Guihua Li Dan Wei Jianzhong Liu Xuezhong Zhou | 2020 | Frontiers of Medicine2020，14，3： | 4 |
| 16 | Effect of externally applied Jidesheng anti-venom on skin and soft-tissue necrosis after Chinese cobra bite: a retrospective study显示文摘OBJECTIVE: To evaluate the effects of Jidesheng anti-venom used externally for skin and soft-tissue necrosis from Chinese cobra bite.METHODS: A retrospective review was performed according to the clinical data recorded from January 2002 to December 2012. A total of 126 patients(116 females and 10 males) with skin and soft-tissue necrosis due to Chinese cobra bite were divided into two groups. The control group was treated externally with 40% glyceride magnesium sulfate(n=52), and the treatment group was given Jidesheng anti-venom externally(n=74). The data collected included maximum local necrotic area of skin and soft tissues, de-tumescence time, healing time,and skin-grafting rate.RESULTS: There were no significant differences in gender, age, and disease condition between the control and treatment groups(P>0.05). No statistically significant difference was found in de-tumescence time between the two groups(P>0.05). The maximum local necrotic area of skin and soft tissues was(19.9 ± 7.3) cm2in the treatment group,while it was(23.3±6.4) cm2in the control group.The healing time of the treatment group was shorter than that of the control group [(32.1 ± 3.7) vs(34.4±4.5) days)] The skin-grafting rate in the treatment group was lower than that of the control group(10.81% vs 25.00%). There were statistically significant differences in maximum local necrotic area of skin and soft tissues, healing time, and skin-grafting rate between the control and treatment groups(all P<0.05).CONCLUSION: External application of Jidesheng anti-venom may help to promote wound healing and reduce the skin-grafting rate in cases of skin and soft-tissue necrosis due to Chinese cobra bite. | Quanfang Chen Wei Wang Qibin Li Yulong Bai Xiaoying Zou Yanbin Wu | 2014 | Journal of Traditional Chinese Medicine2014，34，2： | 3 |
| 17 | Well-construction of Zn_(2)SnO_(4)/SnO_(2)@ZIF-8 core-shell hetero-structure with efficient photocatalytic activity towards tetracycline under restricted space显示文摘Nowadays,efficient removal of antibiotic(e.g.tetracycline,TC) from water bodies has been of great global concern.Hereby,a novel Zn_(2)SnO_(4)/SnO_(2)@ZIF-8 photo-catalyst was first synthesized by a facile selfassembly in-situ growth method.Zn_(2)SnO_(4)/SnO_(2)@ZIF-8 exhibits a remarkable photocatalytic activity towards TC under visible-light driven with a rapid rate constant of 1.5 × 10^(-2)min^(-1), and a removal efficiency of 81.2%,which is superior to some catalysts in the literature.Importantly,the photocatalytic activity of Zn_(2)SnO_(4)/SnO_(2)@ZIF-8 could still remain ~77% after the fifth cycle,indicating its good stability and reusability.The remarkable performances of adsorption and photocatalytic were attributed to associative effects of catalytic activity of Zn_(2)SnO_(4)/SnO_(2)and the unique porous nanostructure and stability of ZIF-8.This work could aid the future design and preparation of novel MOFs composite catalysts for efficient elimination of antibiotics from water. | Jiafei Wu Yuning Jin Danping Wu Xiaoying Yan Na Ma Wei Dai | 2022 | Chinese Journal of Chemical Engineering2022，，12： | 3 |
| 18 | Holocene Abrupt Climate Shifts and Mid-Holocene Drought Intervals Recorded in Barkol Lake of Northern Xinjiang of China显示文摘Study results in this paper have indicated that the Holocene climate in Xinjiang,Northwestern China has been alternating between wet and dry conditions,and was punctuated with a series of abrupt climate shifts.A sediment core taken from Barkol Lake in the northern Xinjiang of Northwest China was analyzed at 1cm interval for grain-size distribution.Abrupt climate shifts revealed by the grain-size proxy occurred at ca 1.4,3.0,4.3,5.6,8.0 cal kyr B.P.,which were well correlated to both the abrupt shifts recorded in the North Atlantic Ocean(NAO)and the Holocene sea surface temperature(SST)cooling events in the Arabian Ocean.The correlation indicated that the climatic changes in the extreme arid Northwest China were associated with the NAO,probably via the North Atlantic Oscillation-affected westerly winds.The strength and position of westerly winds probably modulated the Siberian-Mongolian high-pressure system(winter monsoon),and played an important role in climate change of Northwest China.Moreover,an evident drought interval during the middle Holocene was also revealed by grain-size proxy. | XUE Jibin ZHONG Wei ZHAO Yinjuan PENG Xiaoying | 2008 | Chinese Geographical Science2008，18，1： | 3 |
| 19 | Extension of the low diffusion particle method for near-continuum two-phase flow simulations显示文摘The low diffusion (LD) particle method, proposed by Burt and Boyd, is modified for the near-continuum two-phase flow simulations. The LD method has the advantages of easily coupling with the direct simulation Monte Carlo (DSMC) method for multi-scale flow simulations and dramatically reducing the numerical diffusion error and statistical scatter of the equilibrium particle methods. Liquidor solid-phase particles are introduced in the LD method. Their velocity and temperature updating are respectively, calculated from the motion equation and the temperature equation according to the local gas properties. Coupling effects from condensed phase to gas phase are modeled as momentum and energy sources, which are respectively, equal to the negative values of the total momentum and energy increase in liquid or solid phase. The modified method is compared with theoretical results for unsteady flows, and good agreements are obtained to indicate the reliability of the one-way gas-to-particle coupling models. Hybrid LD-DSMC algorithm is implemented and performed for nozzle discharging gas-liquid flow to show the prospect of the LD-DSMC scheme for multi-scale two-phase flow simulations. | Su Wei He Xiaoying Cai Guobiao | 2013 | Chinese Journal of Aeronautics2013，26，1： | 3 |
| 20 | GF-2 Satellite 1m/4m Camera Design and In-Orbit Commissioning显示文摘GF-2(Gaofen-2) is the second high resolution imaging satellite of China high resolution earth observation system(CHEOS) and it is the first civilian high resolution imager with Ground sample distance(GSD) under1 m in China. The two 1 m/4 m cameras represent a breakthrough in comparison with the previous GF-1 camera. Recent advances in small relative aperture optics system design, vibration reduction, and high accuracy thermal control make it possible for this camera work perfect with high resolution, lihgtweight and high image quality performance. The in-orbit commissioning demonstrates that the performance of the cameras meets all the design requirements. The components of 1 m/4 m camera, the novel techniques adopted and in-orbit commissioning results are illustrated. | HUANG Wei SUN shunrong JIANG Haibin GAO Chao ZONG Xiaoying | 2018 | Chinese Journal of Electronics2018，27，6： | 3 |
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