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| 1 | Ultrafast and broadband photodetectors based on a perovskite/organic bulk heterojunction for large-dynamic-range imaging显示文摘Organic-inorganic hybrid perovskite(OIHP)photodetectors that simultaneously achieve an ultrafast response and high sensitivity in the near-infrared(NIR)region are prerequisites for expanding current monitoring,imaging,and optical communication capbilities.Herein,we demonstrate photodetectors constructed by OIHP and an organic bulk heterojunction(BHJ)consisting of a low-bandgap nonfullerene and polymer,which achieve broadband response spectra up to 1μm with a highest external quantum efficiency of approximately 54%at 850 nm,an ultrafast response speed of 5.6 ns and a linear dynamic range(LDR)of 191 dB.High sensitivity,ultrafast speed and a large LDR are preeminent prerequisites for the practical application of photodetectors.Encouragingly,due to the high-dynamicrange imaging capacity,high-quality visible-NIR actual imaging is achieved by employing the OIHP photodetectors.We believe that state-of-the-art OIHP photodetectors can accelerate the translation of solution-processed photodetector applications from the laboratory to the imaging market. | Chenglong Li Hailu Wang Fang Wang Tengfei Li Mengjian Xu Hao Wang Zhen Wang Xiaowei Zhan Weida Hu Liang Shen | 2020 | Light(Science & Applications)2020，9，1： | 13 |
| 2 | Primary structure of helix C to helix G of a new retinal protein in H.sp.xz515显示文摘The gene fragment encoding the retinal protein from helix C to helix G in a new strain of halobacteria, H.sp.xz515 has been amplified by PCR method. The nucleotide sequence of this fragment has been determined. The deduced amino acid sequence has been compared with halobium br and other two br-like proteins, ar-1 and ar-2. Results show that those amino acid residues in br, essential for proton pumping and binding to retinal, are conserved. The residue M145 in br may be important for isomerization reaction of retinal. | Hui Wang Shuxuan Zhan Qingan Sun Deqiang Xu Wei Zhao Weida Huang Qingguo Li | 2000 | Chinese Science Bulletin2000，45，12： | 5 |
| 3 | Pristine PN junction toward atomic layer devices显示文摘In semiconductor manufacturing,PN junction is formed by introducing dopants to activate neighboring electron and hole conductance.To avoid structural distortion and failure,it generally requires the foreign dopants localize in the designated micro-areas.This,however,is challenging due to an inevitable interdiffusion process.Here we report a brand-new junction architecture,called'layer PN junction',that might break through such limit and help redefine the semiconductor device architecture.Different from all existing semiconductors,we find that a variety of van der Waals materials are doping themselves from n-to p-type conductance with an increasing/decreasing layer-number.It means the capability of constructing homogeneous PN junctions in monolayers'dimension/precision,with record high rectification-ratio(>10^(5))and low cut-off current(<1 pA).More importantly,it spawns intriguing functionalities,like gate-switchable-rectification and noise-signal decoupled avalanching.Findings disclosed here might open up a path to develop novel nanodevice applications,where the geometrical size becomes the only critical factor in tuning charge-carrier distribution and thus functionality. | Hui Xia Man Luo Wenjing Wang Hailu Wang Tianxin Li Zhen Wang Hangyu Xu Yue Chen Yong Zhou Fang Wang Runzhang Xie Peng Wang Weida Hu Wei Lu | 2022 | Light(Science & Applications)2022，11，7： | 4 |
| 4 | A versatile photodetector assisted by photovoltaic and bolometric effects显示文摘The advent of low-dimensional materials with peculiar structure and superb band properties provides a new canonical form for the development of photodetectors.However,the limited exploitation of basic properties makes it difficult for devices to stand out.Here,we demonstrate a hybrid heterostructure with ultrathin vanadium dioxide film and molybdenum ditelluride nanoflake.Vanadium dioxide is a classical semiconductor with a narrow bandgap,a high temperature coefficient of resistance,and phase transformation.Molybdenum ditelluride,a typical two-dimensional material,is often used to construct optoelectronic devices.The heterostructure can realize three different functional modes:(i)the p-n junction exhibits ultrasensitive detection(450 nm-2μm)with a dark current down to 0.2 pA and a response time of 17μs,(ii)the Schottky junction works stably under extreme conditions such as a high temperature of 400 K,and(iii)the bolometer shows ultrabroad spectrum detection exceeding 10μm.The flexible switching between the three modes makes the heterostructure a potential candidate for next-generation photodetectors from visible to longwave infrared radiation(LWIR).This type of photodetector combines versatile detection modes,shedding light on the hybrid application of novel and traditional materials,and is a prototype of advanced optoelectronic devices. | Wei Jiang Tan Zheng Binmin Wu Hanxue Jiao Xudong Wang Yan Chen Xiaoyu Zhang Meng Peng Hailu Wang Tie Lin Hong Shen Jun Ge Weida Hu Xiaofeng Xu Xiangjian Meng Junhao Chu Jianlu Wang | 2020 | Light(Science & Applications)2020，9，1： | 3 |
| 5 | Enhanced U(Ⅵ) bioreduction by alginate-immobilized uranium-reducing bacteria in the presence of carbon nanotubes and anthraquinone-2,6-disulfonate显示文摘Uranium-reducing bacteria were immobilized with sodium alginate, anthraquinone-2,6-disulfonate(AQDS), and carbon nanotubes(CNTs). The effects of different AQDS-CNTs contents, U(Ⅳ) concentrations, and metal ions on U(Ⅳ) reduction by immobilized beads were examined. Over 97.5% U(Ⅵ)(20 mg/L) was removed in 8 hr when the beads were added to 0.7% AQDS-CNTs, which was higher than that without AQDS-CNTs. This result may be attributed to the enhanced electron transfer by AQDS and CNTs. The reduction of U(Ⅵ) occurred at initial U(Ⅵ) concentrations of 10 to 100 mg/L and increased with increasing AQDS-CNT content from 0.1% to 1%. The presence of Fe(Ⅲ), Cu(Ⅱ) and Mn(Ⅱ)slightly increased U(Ⅵ) reduction, whereas Cr(Ⅵ), Ni(Ⅱ), Pb(Ⅱ), and Zn(Ⅱ) significantly inhibited U(Ⅵ) reduction. After eight successive incubation-washing cycles or 8 hr of retention time(HRT) for 48 hr of continuous operation, the removal efficiency of uranium was above 90% and 92%, respectively. The results indicate that the AQDS-CNT/AL/cell beads are suitable for the treatment of uranium-containing wastewaters. | Weida Wang Yali Feng Xinhua Tang Haoran Li Zhuwei Du Aifei Yi Xu Zhang | 2015 | Journal of Environmental Sciences2015，27，5： | 3 |
| 6 | Clinical significance of SOD2 and GSTP1 gene polymorphisms in Chinese patients with gastric cancer显示文摘 | Zhi Xu Haixia Zhu John M. Luk Dongmei Wu Dongying Gu Weida Gong Yongfei Tan Jianwei Zhou Jinhai Tang Zhengdong Zhang Meilin Wang Jinfei Chen | 2012 | Cancer2012，，22： | 2 |
| 7 | Balancing and simulating of assembly line with overlapped and stopped operation 显示文摘 | Fan Wenhua Gao Zhenxiao Xu Weida | 2010 | Simulation Modelling Practice and Theory2010，18，8： | 1 |
| 8 | Development of knowledge-based system for adaptive scheduling using unified modeling language 显示文摘 | WANG Weida XU He LIU Wenjian | 2007 | WSEAS Transactions on Information Science and Applications2007，4，5： | 1 |
| 9 | Sequencing XMET genes to promote genotype-guided risk assessment and precision medicine显示文摘High-throughput next generation sequencing (NGS) is a shotgun approach applied in a parallel fashion by which the genome is fragmented and sequenced through small pieces and then analyzed either by aligning to a known reference genome or by de novo assembly without reference genome.This technology has led researchers to conduct an explosion of sequencing related projects in multidisciplinary fields of science.However,due to the limitations of sequencing-based chemistry,length of sequencing reads and the complexity of genes,it is difficult to determine the sequences of some portions of the human genome,leaving gaps in genomic data that frustrate further analysis.Particularly,some complex genes are difficult to be accurately sequenced or mapped because they contain high GC-content and/or low complexity regions,and complicated pseudogenes,such as the genes encoding xenobiotic metabolizing enzymes and transporters (XMETs).The genetic variants in XMET genes are critical to predicate interindividual variability in drug efficacy,drug safety and susceptibility to environmental toxicity.We summarized and discussed challenges,wet-lab methods,and bioinformatics algorithms in sequencing 'complex' XMET genes,which may provide insightful information in the application of NGS technology for implementation in toxicogenomics and pharmacogenomics. | Yaqiong Jin Geng Chen Wenming Xiao Huixiao Hong Joshua Xu Yongli Guo Wenzhong Xiao Tieliu Shi Leming Shi Weida Tong Baitang Ning | 2019 | Science China(Life Sciences)2019，62，7： | 1 |
| 10 | Genetic variation in C12orf51 is associated with prognosis of intestinal-type gastric cancer in a Chinese population显示文摘 | Gang Zhang Dongying Gu Qinghong Zhao Haiyan Chu Zhi Xu Meilin Wang Cuiju Tang Dongmei Wu Na Tong Weida Gong Jianwei Zhou Yong Xu Zhengdong Zhang Jinfei Chen | 2014 | Biomedicine & Pharmacotherapy2014，，： | 1 |
| 11 | Single-cell RNA Sequencing Reveals Sexually Dimorphic Transcriptome and Type 2 Diabetes Genes in Mouse Islet β Cells显示文摘Type 2 diabetes(T2D)is characterized by the malfunction of pancreaticβcells.Susceptibility and pathogenesis of T2D can be affected by multiple factors,including sex differences.However,the mechanisms underlying sex differences in T2D susceptibility and pathogenesis remain unclear.Using single-cell RNA sequencing(scRNA-seq),we demonstrate the presence of sexually dimorphic transcriptomes in mouseβcells.Using a high-fat diet-induced T2D mouse model,we identified sex-dependent T2D altered genes,suggesting sex-based differences in the pathological mechanisms of T2D.Furthermore,based on islet transplantation experiments,we found that compared to mice with sexmatched islet transplants,sex-mismatched islet transplants in healthy mice showed down-regulation of genes involved in the longevity regulating pathway ofβcells.Moreover,the diabetic mice with sex-mismatched islet transplants showed impaired glucose tolerance.These data suggest sexual dimorphism in T2D pathogenicity,indicating that sex should be considered when treating T2D.We hope that our findings could provide new insights for the development of precision medicine in T2D. | Gang Liu Yana Li Tengjiao Zhang Mushan Li Sheng Li Qing He Shuxin Liu Minglu Xu Tinghui Xiao Zhen Shao Weiyang Shi Weida Li | 2021 | Genomics, Proteomics & Bioinformatics2021，19，3： | 1 |
| 12 | Recent progress and challenges on two-dimensional material photodetectors from the perspective of advanced characterization technologies显示文摘Atomically thin two-dimensional(2D)materials exhibit enormous potential in photodetectors because of novel and extraordinary properties,such as passivated surfaces,tunable bandgaps,and high mobility.High-performance photodetectors based on 2D materials have been fabricated for broadband,position,polarization-sensitive detection,and large-area array imaging.However,the current performance of 2D material photodetectors is not outstanding enough,including response speed,detectivity,and so forth.The way to further promote the development of 2D material photodetectors and their corresponding practical applications is still a tremendous challenge.In this article,these issues of 2D material photodetectors are analyzed and expected to be solved by combining micro-nano characterization technologies.The inherent physical properties of 2D materials and photodetectors can be accurately characterized by Raman spectroscopy,transmission electron microscopy(TEM),and scattering scanning near-field optical microscope(s-SNOM).In particular,the precise probe of lattice defects,doping concentration,and near-field light absorption characteristics can promote the researches of low-noise and high-responsivity photodetectors.Scanning photocurrent microscope(SPCM)can show the overall spatial distribution of photocurrent and analyze the mechanism of photocurrent.Photoluminescence(PL)spectroscopy and Kelvin probe force microscope(KPFM)can characterize the material bandgap,work function distribution and interlayer coupling characteristics,making it possible to design high-performance photodetectors through energy band engineering.These advanced characterization techniques cover the entire process from material growth,to device preparation,and to performance analysis,and systematically reveal the development status of 2D material photodetectors.Finally,the prospects and challenges are discussed to promote the application of 2D material photodetectors. | Fang Zhong Hao Wang Zhen Wang Yang Wang Ting He Peisong Wu Meng Peng Hailu Wang Tengfei Xu Fang Wang Peng Wang Jinshui Miao Weida Hu | 2021 | Nano Research2021，14，6： | 1 |
| 13 | Light-modulated vertical heterojunction phototransistors with distinct logical photocurrents显示文摘The intriguing carrier dynamics in graphene heterojunctions have stimulated great interest in modulating the optoelectronic features to realize high-performance photodetectors.However,for most phototransistors,the photoresponse characteristics are modulated with an electrical gate or a static field.In this paper,we demonstrate a graphene/C_(60)/pentacene vertical phototransistor to tune both the photoresponse time and photocurrent based on light modulation.By exploiting the power-dependent multiple states of the photocurrent,remarkable logical photocurrent switching under infrared light modulation occurs in a thick C_(60) layer(11 nm)device,which implies competition of the photogenerated carriers between graphene/C_(60) and C_(60)/pentacene.Meanwhile,we observe a complete positive-negative alternating process under continuous 405 nm irradiation.Furthermore,infrared light modulation of a thin C_(60)(5 nm)device results in a photoresponsivity improvement from 3425 A/W up to 7673 A/W,and we clearly probe the primary reason for the distinct modulation results between the 5 and 11 nm C_(60) devices.In addition,the tuneable bandwidth of the infrared response from 10 to 3×10^(3) Hz under visible light modulation is explored.Such distinct types of optical modulation phenomena and logical photocurrent inversion characteristics pave the way for future tuneable logical photocurrent switching devices and high-performance phototransistors with vertical graphene heterojunction structures. | Jiayue Han Meiyu He Ming Yang Qi Han Fang Wang Fang Zhong Mengjian Xu Qing Li He Zhu Chongxin Shan Weida Hu Xiaoqing Chen Xinran Wang Jun Gou Zhiming Wu Jun Wang | 2020 | Light(Science & Applications)2020，9，1： | 1 |
| 14 | Genetic variants in the Hedgehog signaling pathway genes are associated with gastric cancer risk in a Chinese Han population显示文摘The Hedgehog signaling pathway participates in the occurrence and progression of cancers including gastric cancer.We conducted this study to evaluate whether genetic variants in the Hedgehog signaling pathway genes would affect gastric cancer risk.Multi-marker Analysis of GenoMic Annotation(MAGMA)was used to investigate the aggregated genetic effects of single nucleotide polymorphisms(SNPs)assigned to candidate genes.The relationship between SNPs and gastric cancer risk was estimated by multivariate logistic regression analyses.Gene expression was calculated using databases obtained from The Cancer Genome Atlas(TCGA)and The Gene Expression Omnibus(GEO).Kaplan‐Meier plotter was used to evaluate the association between gene expression with gastric cancer survival.Tumor Immune Estimation Resource 2.0(TIMER 2.0)was applied to determine the correlation between selected gene expression and the immune cell infiltration degree.We identified that the G allele of rs2990912 in KIF27 was associated with higher gastric cancer risk,especially in the young and male subgroups.The expression of KIF27 in gastric cancer tissues was higher than that in normal tissues,leading to poor survival in gastric cancer patients.Besides,KIF27 expression was related to immune cell infiltration and positively correlated with PD-L1 expression.Our findings highlight the key role of genetic variation in the Hedgehog signaling pathway genes in gastric cancer susceptibility,which may provide important insights into the diagnosis,prognosis,and treatment of gastric cancer. | Yujuan Zhang Kai Lu Xu Wu Hanting Liu Junyi Xin Xiaowei Wang Weida Gong Qinghong Zhao Meilin Wang Haiyan Chu Mulong Du Guoquan Tao Zhengdong Zhang | 2022 | The Journal of Biomedical Research2022，36，1： | 1 |
| 15 | Macroscopic assembled graphene nanofilms based room temperature ultrafast mid-infrared photodetectors显示文摘Graphene with linear energy dispersion and weak electron-phonon interaction is highly anticipated to harvest hot electrons in a broad wavelength range.However,the limited absorption and serious backscattering of hot-electrons result in inadequate quantum yields,especially in the mid-infrared range.Here,we report a macroscopic assembled graphene(nMAG)nanofilm/silicon heterojunction for ultrafast mid-infrared photodetection.The assembled Schottky diode works in 1.5-4.0μm at room temperature with fast response(20-30 ns,rising time,4 mm2 window)and high detectivity(1.61011 to 1.9109 Jones from 1.5 to 4.0μm)under the pulsed laser,outperforming single-layer-graphene/silicon photodetectors by 2-8 orders.These performances are attributed to the greatly enhanced photo-thermionic effect of electrons in nMAG due to its high light absorption(~40%),long carrier relaxation time(~20 ps),low work function(4.52 eV),and suppressed carrier number fluctuation.The nMAG provides a long-range platform to understand the hot-carrier dynamics in bulk 2D materials,leading to broadband and ultrafast MIR active imaging devices at room temperature. | Li Peng Lixiang Liu Sichao Du Srikrishna Chanakya Bodepudi Lingfei Li Wei Liu Runchen Lai Xiaoxue Cao Wenzhang Fang Yingjun Liu Xinyu Liu Jianhang Lv Muhammad Abid Junxue Liu Shengye Jin Kaifeng Wu Miao-Ling Lin Xin Cong Ping-Heng Tan Haiming Zhu Qihua Xiong Xiaomu Wang Weida Hu Xiangfeng Duan Bin Yu Zhen Xu Yang Xu Chao Gao | 2022 | InfoMat2022，4，6： | 1 |
| 16 | Hsa_circ_0002137 stabled by LIN28B promotes osteosarcoma cell growth through the hsa-miR-1246/BCL2 axis显示文摘Circular RNAs(circRNAs)are a novel class of non-coding RNA that have recently shown to have huge capabilities in the regulation of gene expression at the posttranscriptional level.Growing evidence has indicated that circRNAs could serve as competing endogenous RNAs(ceRNAs)to sponge microRNAs(miRNAs)and suppress functions of targeted miRNAs.Osteosarcoma(OS)is the most common malignant primary bone cancer.Hsa_circ_0002137 is upregulated in OS.However,the role of hsa_circ_0002137 in OS remains unclear.Using miRNA pull-down assay,we showed that cir_0002137 sponged hsa-miR-1246,and BCL2 apoptosis regulator(BCL2)mRNA was a potential target of hsa-miR-1246 in human osteosarcoma(HOS)cells.Further,we found that hsa_cir_0002137 could enhance the expression of BCL2 hsa-miR-1246 and promote HOS cell growth through sponging hsa-miR-1246.Moreover,RNA binding protein immunoprecip itation(RIP)assay revealed that lin-28 homolog B(LIN28B)protein associated with hsa_circ_0002137,and LIN28B could increase hsa_circ_0002137 stability and thus accelerate OS cell growth.Our work was the first to study the functions of hsa_circ_0002137,has-miR-1246 and LIN28B in OS,and these results may provide novel therapeutic targets for OS treatment. | FEI ZHANG JIANZHONG LAI RONGHAN HE YI SHI KUN XU SHIHAI JIANG TANGZHAO LIANG WANYU ZHAO WEIDA REN LEI ZHU SONG JIN KUN WANG | 2022 | BIOCELL2022，46，3： | 0 |
| 17 | High-performance violet phosphorus photodetectors with van der Waals-assisted contacts显示文摘Black phosphorus(BP) as a narrow-bandgap two-dimensional semiconductor material has been extensively studied. And the allotrope violet phosphorus(VP) exhibits wide bandgap properties extending the application in the visible light band. However,due to the Schottky barrier of metal/semiconductor contacts(M/S), further device application of VP is limited. Here, VP-based photodetectors with van der Waals-assisted contact were demonstrated, achieving quasi-Ohmic M/S contacts. The output characteristics in dark conditions show ultralow current at the pA level. And the device exhibits a high current on-off ratio of 10~5and a fast response speed of 8.4 ms. Furthermore, we constructed the first allotropic photodetector based on BP and VP heterojunction. The device maintains ultralow dark current(~ pA) while exhibiting faster carrier transport, with 945 μs response time and polarization detection capability. These results offer an effective way to study the optoelectronic properties of VP and promote the study of allotropic heterojunction devices. | Hao Wang Shuling Liu Peng Wang Haonan Ge Yue Chen Hailu Wang Tengfei Xu Jiaxiang Guo Yuanchen Zou Wenrui Wei Ruiqi Jiang Fang Wang Piotr Martyniuk Jinshui Miao Weida Hu | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，9： | 0 |
| 18 | Energy management of hybrid electric propulsion system: Recent progress and a flying car perspective under three-dimensional transportation networks显示文摘The hybrid electric propulsion system(HEPS)holds clear potential to support the goal of sustainability in the automobile and aviation industry.As an important part of the three-dimensional transportation network,vehicles and aircraft using HEPSs have the advantages of high fuel economy,low emission,and low noise.To fulfill these advantages,the design of their energy management strategies(EMSs)is essential.This paper presents an in-depth review of EMSs for hybrid electric vehicles(HEVs)and hybrid electric aircraft.First,in view of the main challenges of current EMSs of HEVs,the referenced research is reviewed according to the solutions facing real-time implementation problems,variable driving conditions adaptability problems,and multi-objective optimization problems,respectively.Second,the existing research on the EMSs for hybrid electric aircraft is summarized according to the hybrid electric propulsion architectures.In addition,with the advance in propulsion technology and mechanical manufacturing in recent years,flying cars have gradually become a reality,further enriching the composition of the three-dimensional transportation network.And EMSs also play an essential role in the efficient operation of flying cars driven by HEPSs.Therefore,in the last part of this paper,the development status of flying cars and their future prospects are elaborated.By comprehensively summarizing the EMSs of HEPS for vehicles and aircraft,this review aims to provide guidance for the research on the EMSs for flying cars driven by HEPS and serve as the basis for knowledge transfer of relevant researchers. | Chao Yang Zhexi Lu Weida Wang Ying Li Yincong Chen Bin Xu | 2023 | Green Energy and Intelligent Transportation2023，2，1： | 0 |
| 19 | Single-cell RNA-sequencing and subcellular spatial transcriptomics facilitate the translation of liver microphysiological systems for regulatory application显示文摘Reducing the use of animal models in drug development and safety assessment has long been supported by the U.S.Food and Drug Administration(FDA).The report by Royal Society for the Prevention of Cruelty to Animals indicates that in 2020,experiments involved the use of over 100 million animals,with the United States leading the list by utilizing 20 million animals.Beyond ethical considerations associated with animal testing and the costs in terms of time and money,animal models are not always effective in predicting human reactions to drug exposure.While animal testing has been the traditional method for assessing the safety and efficacy of drugs. | Dan Li Zhou Fang Qiang Shi Nicholas Zhang Binsheng Gong Weida Tong Ahmet F.Coskun Joshua Xu | 2023 | Journal of Pharmaceutical Analysis2023，13，7： | 0 |
| 20 | Configurable circular-polarization-dependent optoelectronic silent state for ultrahigh light ellipticity discrimination显示文摘Filterless light-ellipticity-sensitive optoelectronic response generally has low discrimination,thus severely hindering the development of monolithic polarization detectors.Here,we achieve a breakthrough based on a configurable circular-polarization-dependent optoelectronic silent state created by the superposition of two photoresponses with enantiomerically opposite ellipticity dependences.The zero photocurrent and the significantly suppressed noise of the optoelectronic silent state singularly enhance the circular polarization extinction ratio(CPER)and the sensitivity to light ellipticity perturbation.The CPER of our device approaches infinity by the traditional definition.The newly established CPER taking noise into account is 3-4 orders of magnitude higher than those of ordinary integrated circular polarization detectors,and it remains high in an expanded wavelength range.The noise equivalent light ellipticity difference goes below 0.009° Hz-1/2 at modulation frequencies above 1000 Hz by a light power of 281 uW.This scheme brings a leap in developing monolithic ultracompact circular polarization detectors. | Yonghao Bu Xiansong Ren Jing Zhou Zhenhan Zhang Jie Deng Hangyu Xu Runzhang Xie Tianxin Li Weida Hu Xia Guo Wei Lu Xiaoshuang Chen | 2023 | Light(Science & Applications)2023，12，8： | 0 |
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