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| 1 | MiR-29b suppresses the proliferation and migration of osteosarcoma cells by targeting CDK6显示文摘Osteosarcoma 是骨头的最普通的主要肉瘤,并且它是在青少年和年轻成年人之中的癌症死亡的一个领先的原因。然而,糟糕位于 osteosarcoma carcinogenesis 遗体下面的分子的机制理解。最近, cyclin 依赖的 kinase (CDK6 ) 6 作为重要 oncogene 被识别。我们发现了那 CDK6 蛋白质水平,而非 CDK6 mRNA 水平,比的在 osteosarcoma 纸巾是高得多的在正常邻近的纸巾,它显示在 osteosarcoma 涉及 CDK6 规定的 post-transcriptional 机制。MiRNAs 是镇压的小非编码的 RNA 在 post-transcriptional 水平的基因表示并且广泛地被显示了在许多人的癌症起重要作用。在这研究,我们用生物信息学方法作为 CDK6 的一个新奇管理者调查了 miR-29b 的角色。我们证明 CDK6 能是由经由到在 osteosarcoma 房间的 3-UTR 区域的绑定的 miR-29b 的 downregulated。而且,我们在 osteosarcoma 纸巾识别了在 miR-29b 和 CDK6 蛋白质层次之间的反的关联。最后,我们在 osteosarcoma 房间检验了 CDK6 表示的 miR-29b-driven 压抑的功能。结果表明 miR-29b 由在增长和移植进程指向 CDK6 充当 osteosarcoma 的肿瘤 suppressor。一起拿,我们的结果在 osteosarcoma 在 CDK6 的规定为 miR-29b 加亮一个重要角色并且可以为未来 osteosarcoma 治疗打开新大街。 | Kegan Zhu Lei Liu Junliang Zhang Yanbo Wang Hongwei Liang Gentao Fan Zhenhuan Jiang Chen-Yu Zhang Xi Chen Guangxin Zhou | 2016 | Protein & Cell2016，7，6： | 18 |
| 2 | SIDT1-dependent absorption in the stomach mediates host uptake of dietary and orally administered microRNAs显示文摘Dietary microRNAs have been shown to be absorbed by mammals and regulate host gene expression,but the absorption mechanism remains unknown.Here,we show that SIDT1 expressed on gastric pit cells in the stomach is required for the absorption of dietary microRNAs.SIDT1-deficient mice show reduced basal levels and impaired dynamic absorption of dietary microRNAs.Notably,we identified the stomach as the primary site for dietary microRNA absorption,which is dramatically attenuated in the stomachs of SIDT1-deficient mice.Mechanistic analyses revealed that the uptake of exogenous microRNAs by gastric pit cells is SIDT1 and low-pH dependent.Furthermore,oral administration of plant-derived miR2911 retards liver fibrosis,and this protective effect was abolished in SIDT1-deficient mice.Our findings reveal a major mechanism underlying the absorption of dietary microRNAs,uncover an unexpected role of the stomach and shed light on developing small RNA therapeutics by oral delivery. | Qun Chen Fan Zhang Lei Dong Huimin Wu Jie Xu Hanqin Li Jin Wang Zhen Zhou Chunyan Liu Yanbo Wang Yuyan Liu Liangsheng Lu Chen Wang Minghui Liu Xi Chen Cheng Wang Chunni Zhang Dangsheng Li Ke Zen Fangyu Wang Qipeng Zhang Chen-Yu Zhang | 2021 | Cell Research2021，31，3： | 10 |
| 3 | Kruppel-like factors and vascular wall homeostasis显示文摘 | Yanbo Fan Haocheng Lu Wenying Liang Wenting Hu Jifeng Zhang Y. Eugene Chen | 2017 | Journal of Molecular Cell Biology2017，9，5： | 7 |
| 4 | Dosage effect of multiple genes accounts for multisystem disorder of myotonic dystrophy type 1显示文摘Multisystem manifestations in myotonic dystrophy type 1(DM1)may be due to dosage reduction in multiple genes induced by aberrant expansion of CTG repeats in DMPK,including DMPK,its neighboring genes(SIX5 or DMWD)and downstream MBNLh However,direct evidence is lacking.Here,we develop a new strategy to generate mice carrying multigene heterozygous mutations to mimic dosage reduction in one step by injection of haploid embryonic stem cells with mutant Dmpk,Six5 and Mbnll into oocytes.The triple heterozygous mutant mice exhibit adult-onset DM1 phenotypes.With the additional mutation in Dmwd,the quadruple heterozygous mutant mice recapitulate many major manifestations in congenital DM1.Moreover,muscle stem cells in both models display reduced sternness,providing a unique model for screening small molecules for treatment of DM1.Our results suggest that the complex symptoms of DM1 result from the reduced dosage of multiple genes. | Qi Yin Hongye Wang Na Li Yifu Ding Zhenfei Xie Lifang Jin Yan Li Qiong Wang Xinyi Liu Liuqing Xu Qing Li Yongjian Ma Yanbo Cheng Kai Wang Cuiqing Zhong Qian Yu Wei Tang Wanjin Chen Wenjun Yang Fan Zhang Chen Ding Lan Bao Bin Zhou Ping Hu Jinsong Li | 2020 | Cell Research2020，30，2： | 7 |
| 5 | Case-control study on the associations between lifestyle-behavioral risk factors and phlegm-wetness cbonstitution显示文摘OBJECTIVE: To explore the relationships between different lifestyle-behavioral factors and phlegm wetness type of Traditional Chinese Medicine constitution,so as to provide health management strategies for phlegm-wetness constitution.METHODS: A case-control study was conducted with the cases selected from the database of Chinese constitution survey in 9 provinces or municipalities of China. 1380 cases met the diagnostic criteria of phlegm-wetness type were taken as the case group, and 1380 cases were randomly selected from gentleness type as the control group. Using Chi-square test to compare the differences of lifestyle-behavior composition in each group; single factor and multiple logistic regression analysis were used to compare the relationships of life-style-behavioral factors and phlegm-wetness type.RESULTS: There were statistically significant differences between phlegm-wetness type group and gentleness type group in lifestyle behaviors(dietary habits, tobacco and liquor consumptions, exercise habits, sleeping habits). The results of single factor logistic regression analysis demonstrated that the risk of phlegm-wetness constitution decreased significantly in light diet(odds ratio, OR=0.68);The risk factors of phlegm-wetness type were fatty food intake(OR=2.36), sleeping early and getting up late(OR=1.87), tobacco smoking(OR=1.83),barbecued food intake(OR=1.68), alcohol drinking(OR=1.63), salty food intake(OR=1.44), sleeping erratically(OR=1.43), less physical activities(OR=1.42), sweet food intake(OR=1.29), sleeping and getting up late(OR=1.26), and pungent food intake(OR=1.21), respectively. Regardless of the interaction among lifestyle-behavioral factors, the results of the multiple logistic regression analysis revealed that the risk factors of phlegm-wetness type were sleeping early and getting up late(OR=1.94), fatty food intake(OR=1.80), tobacco smoking(OR=1.50),sleeping erratically(OR=1.50), barbecued food intake(OR=1.40), sleeping and getting up late(OR=1.40), less physical activities(OR=1.31), sleeping late and getting up early(OR=1.27),and sweet food intake(OR=1.27), respectively, and the risk ofphlegm-wetness type still decreased significantly inlightfoodintake(OR=0.79).CONCLUSION: Light diet can decrease the risk of being phlegm-wetness constitution, and bad lifestyle behaviors such as sleeping early and getting up late, sleeping erratically, fatty food, barbecued food or sweet food intake, tobacco and liquor consumptions, and less physical activities can increase the risks of becoming phlegm-wetness constitution. | Yanbo Zhu Qi Wang Zhaoyu Dai Hideki Origasa Jie Di Yangyang Wang Lin Lin Chunpok Fan | 2014 | Journal of Traditional Chinese Medicine2014，34，3： | 6 |
| 6 | Safety and feasibility of transulnar versus transradial artery approach for coronary catheterization in non-selective patients显示文摘 | Geng Wei Fu Xianghua Gu Xinshun Jiang Yunfa Fan Weize Wang Yanbo Li Wei Xing Kun Liu Chen | 2014 | Chinese Medical Journal2014，，7： | 5 |
| 7 | Cyclical helping hands: seasonal tailwinds differentially affect migrating Oriental Storks (Ciconia boyciana) travel speed显示文摘Background:The Oriental Stork(Ciconia boyciana)breeds in southeastern Siberia and parts of northeast China,and winters mainly in southeast China.Although the autumn migration pattern of Oriental Storks has been previ-ously described,differences between spring and autumn migration travel speed in relation to wind assistance were unknown.Methods:Using GPS/GSM transmitters,we tracked the full migrations of 18 Oriental Storks during 2015-2018 to compare differences in autumn and spring migration patterns,and combined the satellite telemetry data with the National Center for Environmental Prediction Reanalysis data to explain the relationship between 850 mbar wind vec-tors and seasonal differences in travel speed.Results:Differences in tailwinds contributed to significant differences in daily average Oriental Storks travel speed in spring(258.11±64.8 km/day)compared to autumn(172.23±49.7 km/day,p<0.001).Storks stopped significantly more often in autumn than spring(1.78±1.1 versus 1.06±0.9,p<0.05),but stopover duration(15.52±12.4 versus 16.30±15.1 days,respectively,p=0.3)did not differ significantly.Tailwinds at 850 mbar pressure level(extracted from the National Center of Environmental Prediction Reanalysis data archive)significantly affected daily flying speed dur-ing spring and autumn migration.Tailwind conditions in spring(mean 4.40±5.6 m/s)were always more favourable than in autumn when they received no net benefit(0.48±5.6 m/s,p<0.001).Despite mean spring migration dura-tion being less than autumn(27.52±15.9 versus 32.77±13.4 days,p=0.17),large individual variation meant that this duration did not differ significantly from each other.Conclusions:For long distance migratory soaring birds(such as storks),relative duration of spring and autumn migration likely relates to the interaction between imperative for earliest arrival to breeding grounds and seasonal meteorological conditions experienced en route. | Shujuan Fan Qingshan Zhao Hongbin Li Baoguang Zhu Shubin Dong Yanbo Xie Lei Cao Anthony David Fox | 2020 | Avian Research2020，11，2： | 2 |
| 8 | Deep learning assisted variational Hilbert quantitative phase imaging显示文摘We propose a high-accuracy artifacts-free single-frame digital holographic phase demodulation scheme for relatively lowcarrier frequency holograms-deep learning assisted variational Hilbert quantitative phase imaging(DL-VHQPI).The method,incorporating a conventional deep neural network into a complete physical model utilizing the idea of residual compensation,reliably and robustly recovers the quantitative phase information of the test objects.It can significantly alleviate spectrum-overlapping-caused phase artifacts under the slightly off-axis digital holographic system.Compared to the conventional end-to-end networks(without a physical model),the proposed method can reduce the dataset size dramatically while maintaining the imaging quality and model generalization.The DL-VHQPI is quantitatively studied by numerical simulation.The live-cell experiment is designed to demonstrate the method's practicality in biological research.The proposed idea of the deep learning-assisted physical model might be extended to diverse computational imaging techniques. | Zhuoshi Li Jiasong Sun Yao Fan Yanbo Jin Qian Shen Maciej Trusiak Maria Cywińska Peng Gao Qian Chen Chao Zuo | 2023 | Opto-Electronic Science2023，2，4： | 1 |
| 9 | C and N stable isotope analysis of human and animal bones at the Beiqian site显示文摘The Beiqian site,located in Jimo city,Qingdao,went through three archaeological excavations,and a large number of human and animal bones in the Dawenkou culture and the Zhou Dynasty period were unearthed.By carbon and nitrogen stable isotope analysis,the diet of ancestors is expected to be recovered,and the domesticated plants and animals will be discussed.The investigated results showed that the food structure of ancestors in both periods included food crops,mainly C4 foods,and meat,mainly marine shellfish and livestock.For domestic pigs,they mainly eat C3 plants,and were affected by the lifestyle of ancestors.This study also showed that the diet of ancestors is the shellfish rather than marine fish despite the Beiqian site is located near the shoreline.We can conclude that the diet of ancestors in Dawenkou culture period included millet crops(C4plants),shellfish,marine food,and livestock,representing the lifestyle of farming,domestication,and fishing,supplemented by hunting.In the Zhou dynasty period the meat resource was enriched by domesticated animals and marine fisheries,and the living conditions were significantly improved. | WANG Fen SONG YanBo LI BaoShuo FAN Rong JIN GuiYun YUAN ShiLing | 2014 | Science China Earth Sciences2014，57，3： | 1 |
| 10 | PPARs and the cardio- vascular system显示文摘 | Milton Hamblin Lin Chang Yanbo Fan | 2009 | Antioxid Redox Signal2009，11，： | 1 |
| 11 | Discontinuous streaming potential via liquid gate显示文摘Streaming potential is mainly related to electrokinetic energy conversion,which has been considered to show promising potential for advanced technologies,especially sensing.The inherent property of streaming potential is that the energy conversion process is always a continuous state.However,practical applications include many cases of discontinuous states,such as nonlinear sensing.Here,we report a discontinuous streaming potential electrokinetic energy conversion fluid system.Experiments and theoretical calculations reveal that this system exhibits a discontinuous electrokinetic effect and provides a gating liquid slip in micropores,offering the advantages of gating liquid charge coupling and interfacial drag reduction.Moreover,the system is demonstrated in a wearable fall-down alert application.We expect this liquid gating energy conversion system to open up a platform for the design and application of autonomous health monitoring devices,seismic sea wave warning systems,and beyond. | Jian Zhang Kan Zhan Shusong Zhang Yigang Shen Yaqi Hou Jing Liu Yi Fan Yunmao Zhang Shuli Wang Yanbo Xie Xinyu Chen Xu Hou | 2022 | eScience2022，2，6： | 0 |
| 12 | Characterization on Modification and Biocompatibility of PCL Scaffold Prepared with Near-field Direct-writing Melt Electrospinning显示文摘In this study,orthogonal experiments were designed to explore the optimal process parameters for preparing polycaprolactone(PCL)scaffolds by the near-field direct-writing melt electrospinning(NFDWMES)technology.Based on the optimal process parameters,the PCL scaffolds with different thicknesses,gaps and structures were manufactured and the corresponding hydrophilicities were characterized.The PCL scaffolds were modified by chitosan(CS)and hyaluronic acid(HA)to improve biocompatibility and hydrophilicity.Both Fourier transform infrared spectroscopy(FTIR)analysis and antibacterial experimental results show that the chitosan and hyaluronic acid adhere to the surface of PCL scaffolds,suggesting that the modification plays a positive role in biocompatibility and antibacterial effect.The PCL scaffolds were then employed as a carrier to culture cells.The morphology and distribution of the cells observed by a fluorescence microscope demonstrate that the modified PCL scaffolds have good biocompatibility,and the porous structure of the scaffolds is conducive to adhesion and deep growth of cells. | CHEN Zhijun HAO Ming QIAN Xiaoming CHEN Wenyang ZENG Ming HUANG Juan LI Ruixin FAN Jintu LIU Yanbo | 2021 | Chemical Research in Chinese Universities2021，37，3： | 0 |
| 13 | Prevalence and Severity of HBV-Associated Acute-on-Chronic Liver Failure Due to Irregular Medication of Nucleos(t)ide Analogs显示文摘Hepatitis B virus(HBV)represents the commonest etiologic agent of acute-on-chronic liver failure(ACLF)in most Asian countries.Nucleos(t)ide analogs(NAs)are effective in the treatment of chronic HBV infections,but may also exacerbate the disease and stimulate its development into HBV-associated ACLF if not used appropriately.The current study aimed to assess the prevalence and severity of HBV-associated ACLF as a result from irregular medication of NAs(IMNA).A total of 1134 individuals with HBV-associated ACLF in nine hospitals in Heilongjiang Province were enrolled in this study between 2005 and 2015.Among these,777 chronic hepatitis B(CHB)and 357 HBV-associated liver cirrhosis cases were classified based on various predisposing factors,including IMNA,HBV reactivation(HBVR),infections,treatment drugs,alcohol use and others(hepatitis C virus,hepatitis E virus,gastrointestinal bleeding and unknown reasons).The percentage and improvement rate were examined.Among individuals with HBV-associated ACLF and CHB,IMNA was found in 9.01%,HBVR in 46.20%,infections in 9.52%,treatment drugs in 14.67%,alcohol in 11.71%,and others in 24.58%as predisposing factors.Improvement rates in cases with IMNA,HBVR,infections,treatment drugs,alcohol and others were 41.43%,58.50%,58.11%,56.14%,53.85%,and 65.97%,respectively.Multivariable analysis showed that IMNA,others,infections,hepatic encephalopathy and hepatorenal syndrome were associated with prognosis.Only IMNA independently predicted HBV-associated ACLF prognosis.Overall,our study demonstrated that the percentage of IMNAinduced HBV-associated ACLF was 12.61%,and worse disease conditions resulted from IMNA compared with other factors.Thus,the suitability of treatment with NAs should be thoroughly evaluated. | Ying Zheng Shu Chen Yanxin Huang Lisheng Jiang Yongguo Li Yinghua Lan Shuchen Li Yuqin Xu Xiaodong Li Hongwei Zhao Yanbo Wang Ying Shen Chao Wei Honglin Zhou Rongshan Fan Xiqiu Zeng Mingxia Jiang Shupeng Song Mingyan Xu | 2021 | Infectious Microbes & Diseases2021，3，4： | 0 |
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