|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Variable frequency of pulse hydraulic fracturing for improving permeability in coal seam显示文摘Variable frequency,a new pattern of pulse hydraulic fracturing,is presented for improving permeability in coal seam.A variable frequency pulse hydraulic fracturing testing system was built,the mould with triaxial loading was developed.Based on the monitor methods of pressure sensor and acoustic emission,the trials of two patterns of pulse hydraulic fracturing of single frequency and variable frequency were carried out,and at last fracturing mechanism was analyzed.The results show that the effect of variable frequency on fracture extension is better than that of single frequency based on the analysis of macroscopic figures and AE.And the shortage of single frequency is somewhat remedied when the frequency is variable.Under variable frequency,the pressure process can be divided into three stages:low frequency band,pressure stability band and high frequency band,and rupture pressure of the sample is smaller than that of the condition of single frequency.Based on the Miner fatigue theory,the effect of different loading sequences on sample rupture is discussed and the results show that it is better to select the sequence of low frequency at first and then high frequency.Our achievements can give a basis for the improvement and optimization of the pulse hydraulic fracturing technology. | Li Quangui Lin Baiquan Zhai Cheng Ni Guanhua Peng Shen Sun Chen Cheng Yanying | 2013 | International Journal of Mining Science and Technology2013，23，6： | 12 |
| 2 | Efficacy and safety of low-dose interleukin-2 in combination with methotrexate in patients with active rheumatoid arthritis:a randomized,double-blind,placebo-controlled phase 2 trial显示文摘Rheumatoid arthritis(RA)is an aggressive autoimmune arthritis,and current therapies remain unsatisfactory due to low remission rate and substantially adverse effects.Low-dose interleukin-2(Ld-IL2)is potentially a therapeutic approach to further improve the disease.This randomized,double-blind,placebo-controlled trial was undertaken to evaluate the efficacy and safety of Ld-IL2 in patients with active RA.Patients were randomly assigned(1:1)to receive Ld-IL2,defined as a dose of 1 million IU,or placebo in a 12-week trial with a 12-week follow-up.Three cycles of Ld-IL2 or placebo were administered subcutaneously every other day for 2 weeks(a total of 7 doses),followed by a 2-week break.All patients received a stable dose of methotrexate(MTX).The primary outcomes were the proportion of patients achieving the ACR20,DAS28-ESR<2.6,and the change from baseline in CDAI or SDAI at week 24.Secondary endpoints included other clinical responses and safety.The primary outcomes were achieved in the perprotocol population.The improvements from baseline in CDAI and SDAI were significantly greater across time points for the LdIL2+MTX group(n=17)than for the placebo+MTX group(n=23)(P=0.018 and P=0.015,respectively).More patients achieved ACR20 response in the Ld-IL2+MTX group than those in the placebo+MTX group at week 12(70.6%vs 43.5%)and at week 24(76.5%vs 56.5%)(P=0.014).In addition,low Treg and high IL-21 were associated with good responses to Ld-IL2.Ld-IL-2 treatment was well-tolerated in this study.These results suggested that Ld-IL2 was effective and safe in RA.ClinicalTrials.gov number:NCT 02467504. | Xiaoying Zhang Miao Miao Ruijun Zhang Xu Liu Xiaozhen Zhao Miao Shao Tian Liu Yuebo Jin Jiali Chen Huixin Liu Xia Zhang Yun Li Yunshan Zhou Yue Yang Ru Li Haihong Yao Yanying Liu Chun Li Yuhui Li Limin Ren Yin Su Xiaolin Sun Jing He Zhanguo Li | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 7 |
| 3 | Transformative hyaluronic acid-based active targeting supramolecular nanoplatform improves long circulation and enhances cellular uptake in cancer therapy显示文摘Hyaluronic acid(HA) is a natural ligand of tumor-targeted drug delivery systems(DDS) due to the relevant CD44 receptor overexpressed on tumor cell membranes. However, other HA receptors(HARE and LYVE-1) are also overexpressing in the reticuloendothelial system(RES). Therefore,polyethylene glycol(PEG) modification of HA-based DDS is necessary to reduce RES capture.Unfortunately, pegylation remarkably inhibits tumor cellular uptake and endosomal escapement,significantly compromising the in vivo antitumor efficacy. Herein, we developed a Dox-loaded HA-based transformable supramolecular nanoplatform(Dox/HCVBP) to overcome this dilemma. Dox/HCVBP contains a tumor extracellular acidity-sensitive detachable PEG shell achieved by a benzoic imine linkage.The in vitro and in vivo investigations further demonstrated that Dox/HCVBP could be in a 'stealth' state at blood stream for a long circulation time due to the buried HA ligands and the minimized nonspecific interaction by PEG shell. However, it could transform into a 'recognition' state under the tumor acidic microenvironment for efficient tumor cellular uptake due to the direct exposure of active targeting ligand HA following PEG shell detachment. Such a transformative concept provides a promising strategy to resolve the dilemma of natural ligand-based DDS with conflicting two processes of tumor cellular uptake and in vivo nonspecific biodistribution. | Lu Zhong Lu Xu Yanying Liu Qingsong Li Dongyang Zhao Zhenbao Li Huicong Zhang Haotian Zhang Qiming Kan Yongjun Wang Jin Sun Zhonggui He | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 7 |
| 4 | Scalable and ultrafast epitaxial growth of single-crystal graphene wafers for electrically tunable liquid-crystal microlens arrays显示文摘The scalable growth of wafer-sized single-crystal graphene in an energy-efficient manner and compatible with wafer process is critical for the killer applications of graphene in high-performance electronics and optoelectronics. Here, ultrafast epitaxial growth of single-crystal graphene wafers is realized on singlecrystal Cu90Ni10(1 1 1) thin films fabricated by a tailored two-step magnetron sputtering and recrystallization process. The minor nickel(Ni) content greatly enhances the catalytic activity of Cu, rendering the growth of a 4 in. single-crystal monolayer graphene wafer in 10 min on Cu90Ni10(1 1 1), 50 folds faster than graphene growth on Cu(1 1 1). Through the carbon isotope labeling experiments, graphene growth on Cu90Ni10(1 1 1) is proved to be exclusively surface-reaction dominated, which is ascribed to the Cu surface enrichment in the Cu Ni alloy, as indicated by element in-depth profile. One of the best benefits of our protocol is the compatibility with wafer process and excellent scalability. A pilot-scale chemical vapor deposition(CVD) system is designed and built for the mass production of single-crystal graphene wafers, with productivity of 25 pieces in one process cycle. Furthermore, we demonstrate the application of single-crystal graphene in electrically controlled liquid-crystal microlens arrays(LCMLA), which exhibit highly tunable focal lengths near 2 mm under small driving voltages. By integration of the graphene based LCMLA and a CMOS sensor, a prototype camera is proposed that is available for simultaneous light-field and light intensity imaging. The single-crystal graphene wafers could hold great promising for highperformance electronics and optoelectronics that are compatible with wafer process. | Bing Deng Zhaowei Xin Ruiwen Xue Shishu Zhang Xiaozhi Xu Jing Gao Jilin Tang Yue Qi Yani Wang Yan Zhao Luzhao Sun Huihui Wang Kaihui Liu Mark H. Rummeli Lu-Tao Weng Zhengtang Luo Lianming Tong Xinyu Zhang Changsheng Xie Zhongfan Liu Hailin Peng | 2019 | Science Bulletin2019，64，10： | 4 |
| 5 | Long-term stable silver nanowire transparent composite as bottom electrode for perovskite solar cells显示文摘作为传统的铟听氧化物(ITO ) 的最有希望的选择,银 nanowire (AgNW ) 有改进稳定性的合成透明电极在各种各样的设备与太古的 AgNWs 网络的相比被表明了。然而,象为 perovskite 太阳能电池的底部电极合成的稳定的 AgNW/polymer 还没被报导了。这里,与修改抗氧化剂的 chitosan 聚合物合成的长期的稳定的、光滑的 AgNW 被开发。修改聚合物能有效地与 perovskite 保护太古的 AgNWs 免受方面反应的伤害,而它不通过绝缘的聚合物的接口堵住搬运人飘移。同样准备的 AgNW/polymer 合成电极在 50 m 的一种扫描尺寸在 10 nm 下面展出了根平均数平方粗糙 ????? | Yunxia Jin Yong Sun Kaiqing Wang Yani Chen Ziqi Liang Yuxi Xu Fei Xiao | 2018 | Nano Research2018，11，4： | 4 |
| 6 | The protective effect of 17 beta-estradiol on oxygen-induced retinopathy and its relation with the changes of malondialdehyde显示文摘Objective:Retinopathy of prematurity is becoming obvious with the improvement of neonatal ambulance. However there is still not a good treatment. The present study is to observe the effect of 17 beta-estradiol (E2) on oxygen-induced retinopathy (OIR), and explore the relationship between the changes of avascular area and malondialdehyde (MDA) in retina. Methods: Newborn oxygen-exposed mice underwent subcutaneous injections of different dose of E2 (0.1 μg, 1.0 μg, 10.0 μg ), tamoxifen or phosphate buffered saline (PBS; controls)everyday from post-natal day (p)7 to p17. At p17, retinal flat mounts were scored for the percentage of avascular/total retinal area, and pathological changes during revascularization. The MDA concentration in the retina was determined also. In the most efficacious E2 group (10.0 μg), 100.0 μg tamoxifen was also administered, and the percentage of capillary-free/total retinal area determined, and the retinal malondialdehyde concentration assayed. Results: The mean percentage of capillary-free area over total retinal area was 0(PBS, in room air), 34.197±1.301(PBS, in hyperoxia), 23.685±0.407 (0.1 μg E2), 14.648±0.355 (1.0 μg E2), 4.693±0.450 (10.0 μg E2) and 32.240±0.654 (10.0 μg E2 +100.0 μg tamoxifen). The difference was significant (F=2778.759, P<0.01), and the difference between any two groups were also significant (all P value were less than 0.01). The predilection of tufts and clusters during revascularization was mainly aggregated in zones 2 and 3, but the difference of retinal neovascular clusters and tufts in fourth zone among different groups were significant [clusters (F=44.719, P<0.01) vs tufts (F =39.997,P<0.01)]. The mean MDA concentration were 0.711±0.037(PBS, in room air), 2.084±0.066 (PBS, in hyperoxia), 1.829±0.091(0.1 μg E2), 1.152±0.067(1.0 μg E2), 0.796±0.027(10.0 μg E2), 1.988±0.049(10.0 μg E2 +100.0 μg tamoxifen) (F=628.103, P<0.01). The difference between any two groups were also significant (all P value were less than 0.05). The close relation between the percentage of avascular/total retinal area and MDA concentration was also verified (r=0.981, P<0.01). Conclusion: Oxidative stress responses play a pivotal role in OIR, by means of receptor pathway. E2 can alleviate oxidative stress reaction, and thus ameliorate the severity of oxygen induced retinopathy. | Hongbing Zhang Naixue Sun Houcheng Liang Xianghua Xiao Xianning Liu Yani Wang | 2010 | The Journal of Biomedical Research2010，24，2： | 3 |
| 7 | Origin area and migration route: Chloroplast DNA diversity in the arctic-alpine plant Koenigia islandica显示文摘The Hengduan Mountains(henceforth H-D Mountains) on the Tibet Plateau are a distribution and diversity center for many alpine genera. We examine patterns of genetic variation in an arctic-alpine plant to evaluate the possibility that the H-D Mountains constitute the area of origin of the species as well as to uncover postglacial migration routes. 220 individuals of the arctic-alpine plant Koenigia islandica were sampled from 26 populations distributed in western China and northern Finland. DNA haplotypes were identified using restriction site analysis of two chloroplast DNA intergene spacer regions, atpB-rbcL and trnL-trnF. We examined the geographical distribution of haplotype diversity in relation to latitude, and also compared various indices of diversity in putatively glaciated and unglaciated regions. Patterns of migration were inferred using nested clade analysis. A total of 25 haplotypes were detected. High haplotype diversity was found in the H-D Mountains. H3 and its radiated haplotypes were distributed in the Himalayas. Two haplotypes were fixed concurrently in the H-D Mountains and northern Finland. High genetic diversity of K. islandica and high species diversity of K. islandica are expected in the origin area. Our observations suggest that the H-D Mountains are not only the place of origin of K. islandica, but also the refugia for K. islandica on the Tibet Plateau. What is more, the migration route for the arctic-alpine plant K. islandica must have originated in the region defined by the H-D Mountains in western China extending northward to the Arctic circumpolar, and moved westward along the Himalayas, then northward across the Altay Mountains and the Central Siberian Plateau at different time periods. | LONG Cong MIN YunJiang ZHAO XiuXia YANY ChunLei SUN Hang Lü HouYuan TANG LingYu ZHOU ZhongZe | 2014 | Science China Earth Sciences2014，57，8： | 2 |
| 8 | Glucose-responsive erythrocyte-bound nanoparticles for continuously modulated insulin release显示文摘Glucose-responsive closed-loop insulin delivery systems represent a promising treatment strategy for diabetes,but current systems generally cannot achieve long-term effects.In this study,we designed an erythrocyte-biomimetic glucose-responsive system(EGRS)by coupling glucose-responsive nanoparticles(GRNs)to red blood cells;these nanoparticles exhibited the dual functions of glucose-responsiveness and persistent presence in circulation.GRNs are generated by encapsulating with insulin through ion crosslinking,followed by coloading with glucose oxidase(GOx)and catalase(CAT),a process that endows the nanoparticles with glucose-responsiveness.Simultaneously,the GRNs are coupled with red blood cells to camouflage them from the immune system,therefore,these erythrocyte-coupled GRNs can circulate in the blood for a long time.Under conditions of hyperglycemia,GOx acts on blood glucose to produce gluconic acid,which causes the rupture of GRNs and efficient release of insulin.Conversely,insulin is only released at the basic rate during hypoglycemia.Thus,EGRS can efficiently and continuously respond to hyperglycemia to maintain blood glucose levels within the normal range. | Xiaomin Xu Yani Xu Yuai Li Min Li Leilei Wang Qiang Zhang Bingjie Zhou Qing Lin Tao Gong Xun Sun Zhirong Zhang Ling Zhang | 2022 | Nano Research2022，15，6： | 2 |
| 9 | Simulation of Shallow Gas Invasion Process During Deepwater Drilling and Its Control Measures显示文摘Shallow gas is considered one of the most serious geological hazards in deepwater drilling because it has the characteristics of suddenness and is difficult to deal with.To perform a quantitative evaluation of shallow gas risk during deepwater drilling,a numerical model for calculating gas invasion volume is established based on gas-water two-phase flow theory.The model considers the effect of the dynamic drilling process,and the influencing factors which affect the gas invasion volume are analyzed.Results indicate that the gas invasion rate and accumulated gas invasion volume increase with increasing bottom-hole pressure difference.A linear relationship exists between gas invasion volume and bottom-hole pressure difference.The duration of gas invasion increases as the shallow gas zone thickness increases,and the accumulated gas invasion volume grows as shallow gas zone thickness increases.The increase in formation permeability,water depth,and rate of penetration will enhance the gas invasion rate.However,these three factors can hardly affect the accumulated gas invasion volume.The gas flow rate increases significantly with increasing burial depth of shallow gas.On the basis of influencing factor analysis,a series of methods that consider different risk levels is proposed to control shallow gas,which can provide a reference for the prevention of shallow gas disasters during deepwater drilling. | LEI Yani SUN Jin WANG Guangjian | 2022 | Journal of Ocean University of China2022，21，3： | 1 |
| 10 | The Gold Coast criteria increases the diagnostic sensitivity for amyotrophic lateral sclerosis in a Chinese population显示文摘Objectives:The aim of this study was to assess and compare the diagnostic utility of a new diagnostic criteria for amyotrophic lateral sclerosis(ALS),abbreviated as the‘Gold Coast Criteria’,with the revised El Escorial(rEEC)and Awaji criteria.Methods:Clinical and electrophysiological data of 1185 patients from January 2014 to December 2019 in the Peking Union Medical College Hospital ALS database were reviewed.The sensitivity of the Gold Coast criteria was compared to that of the possible rEEC and Awaji criteria(defined by the proportion of patients categorized as definite,probable,or possible ALS).Results:A final diagnosis of ALS was recorded in 1162 patients.The sensitivity of the Gold Coast criteria(96.6%,95%confidence interval[CI]=95.3%-97.5%)was greater than that of the rEEC(85.1%,95%CI=82.9%-87.1%)and Awaji(85.3%,95%CI=83.2%-87.3%).In addition,the sensitivity of the novel criteria maintained robust across subgroups,and the advantage was more prominent in limb-onset ALS patients and those who completed electromyographic tests.In those who did not achieve any of the rEEC diagnostic categories,the sensitivity of Gold Coast criteria was 84.4%.Conclusions:The current study demonstrated that the Gold Coast criteria exhibited greater diagnostic sensitivity than the rEEC and Awaji criteria in a Chinese ALS population.The application of the Gold Coast criteria should be considered in clinical practice and future therapeutic trials. | Dongchao Shen Xunzhe Yang Yanying Wang Di He Xiaohan Sun Zhengyi Cai Jinyue Li Mingsheng Liu Liying Cui | 2021 | Translational Neurodegeneration2021，10，3： | 1 |
| 11 | Study on the performance of ramie fiber modified with ethylenediamine显示文摘 | Zhao-Tie Liu Yani Yang Lili Zhang Ping Sun Zhong-Wen Liu Jian Lu Heping Xiong Yuande Peng Shouwei Tang | 2007 | Carbohydrate Polymers2007，，1： | 1 |
| 12 | A fiber Fabry–Perot interferometer based on a PVA coating for humidity measurement显示文摘 | Dan Su Xueguang Qiao Qiangzhou Rong Hao Sun Jing Zhang Zhengyuan Bai Yanying Du Dingyi Feng Yupeng Wang Manli Hu Zhongyao Feng | 2013 | Optics Communications2013，，： | 1 |
| 13 | Temperature and refractive index sensing characteristics of an MZI-based multimode fiber–dispersion compensation fiber–multimode fiber structure显示文摘 | Hao Sun Shen Yang Jing Zhang Qiangzhou Rong Lei Liang Qinfang Xu Guanghua Xiang Dingyi Feng Yanying Du Zhongyao Feng Xueguang Qiao Manli Hu | 2012 | Optical Fiber Technology2012，，6： | 1 |
| 14 | Effect of Ti layer thickness on microstructure and magnetic properties of Ti/Co/Ti films显示文摘TiCoTi granular films were prepared by DC facing-target magnetron sputtering system onto glass substrates and subsequently in situ annealing in vacuum. Structural of Ti (t nm)/Co (40 nm)/Ti (t nm) films were investigated in detail, which shows that the majority Co nanograins are formed as the hexagonal-close-packed (HCP) structure. Vibrating sample magnetometer (VSM) and scanning probe microscope (SPM) were applied to study the magnetic properties, morphologies and domain structures of these samples. It has been found that the structure and magnetic properties of the Ti/Co/Ti films depend strongly on the Ti layer thickness. The out-of-plane coercivities (Hc) of the film is maximum about 78.8 kA·m-1 when t=5 nm with annealing at 300 ℃; the distributing of grains of the sample is uniformity; and the average size of particles is about 13 nm. The obtained results suggest that this system is perpendicular anisotropy and might be applicable to perpendicular magnetic recording media. | ZHANG Yujie ZHANG Hanwei FENG Shunzhen SUN Huiyuan HU Yanying PENG Yan | 2006 | Rare Metals2006，25，z1： | 1 |
| 15 | Exploring the relationship of hyaluronic acid molecular weight and active targeting efficiency for designing hyaluronic acid-modified nanoparticles显示文摘Although it is reported that the targeting ability of hyaluronic acid(HA)-based nanoparticles(NPs) is molecular weight(MW) dependent,the influence of HA MW on targeting efficiency of HA-functionalized NPs and the underlying mechanism remain elusive. In this study,we constituted three HA-functionalized Dox-loaded NPs(Dox/HCVs) different HA MWs(7,63,and 102 k Da) and attempted to illustrate the effects of HA MW on the targeting efficiency.The three Dox/HCVs had similar physiochemical and pharmaceutical characteristics,but showed different affinity to CD44 receptor. Furthermore,Dox/HCV-63 exerted the best targeting effect and the highest cytotoxicity compared with Dox/HCV-7 and Dox/HCV-102. It was interesting to found that both the HA-CD44 binding affinity and induced CD44 clustering by HA-based NPs were HA MW-dependent,the two of which determine the apparent targeting efficacy of Dox/HCV NPs in the conflicting directions. Those results laid a good foundation for rationally designing HA-based NPs in cancer therapy. | Lu Zhong Yanying Liu Lu Xu Qingsong Li Dongyang Zhao Zhenbao Li Huicong Zhang Haotian Zhang Qiming Kan Jin Sun Zhonggui He | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，5： | 1 |
| 16 | Development and application of an indirect ELISA for detection of antibodies against avian hepatitis E virus显示文摘 | Qin Zhao Yani Sun Jinan Zhao Shoubin Hu Feifei Zhao Fuyong Chen Alfonso Clavijo En-Min Zhou Yihong Xiao | 2013 | Journal of Virological Methods2013，，1： | 1 |
| 17 | Boronic acid-containing diarylpyrimidine derivatives as novel HIV-1NNRTIs: Design, synthesis and biological evaluation显示文摘Drug resistance remains to be a serious problem with type Ⅰ human immunodeficiency virus(HIV-1) nonnucleoside reverse transcriptase inhibitors(NNRTIs). A series of novel boronic acid-containing diarylpyrimidine(DAPY) derivatives were designed via bioisosterism and scaffold-hopping strategies,taking advantage of the ability of a boronic acid group to form multiple hydrogen bonds. The target compounds were synthesized and evaluated for their anti-HIV activities and cytotoxicity in MT-4 cells.Compound 10 j yielded the most potent activity and turned out to be a single-digit nanomolar inhibitor towards the HIV-1 ⅢB [wild-type(WT) strain], L100 I and K103 N strains, with 50% effective concentration(EC_(50)) values of 7.19–9.85 nmol/L. Moreover, 10 j inhibited the double-mutant strain RES056 with an EC_(50) value of 77.9 nmol/L, which was 3.3-more potent than that of EFV(EC_(50)= 260 nmol/L) and comparable to that of ETR(EC_(50)= 32.2 nmol/L). 10j acted like classical NNRTIs with high affinity for WT HIV-1 reverse transcriptase(RT) with 50% inhibition concentration(IC_(50)) value of 0.1837 μmol/L. Furthermore,molecular dynamics simulation indicated that 10 j was proposed as a promising molecule for fighting against HIV-1 infection through inhibiting RT activity. Overall, the results demonstrated that 10 j could serve as a lead molecule for further modification to address virus-drug resistance. | Da Feng Fenju Wei Yanying Sun Prem Prakash Sharma Tao Zhang Hao Lin Brijesh Rathi Erik De Clercq Christophe Pannecouque Dongwei Kang Peng Zhan Xinyong Liu | 2021 | Chinese Chemical Letters2021，32，12： | 1 |
| 18 | Grafting of MIPs from PVDF Membranes via Reversible Addition-fragmentation Chain Transfer Polymerization for Selective Removal of p-Hydroxybenzoic Acid显示文摘 | DONG Yanying YU Ping SUN Qilong LU Yang TAN Zhenjiang YU Xiaopeng | 2018 | Chemical Research in Chinese Universities2018，34，6： | 0 |
| 19 | Altered influenza virus haemagglutinin(HA)-derived peptide is potent therapy for CIA by inducing Th1 to Th2 shift显示文摘There has been an increase in interest in the use of altered peptides as antigen-specific therapeutic agents in autoimmune diseases.Here we investigated the inhibitory effect and possible mechanism of an altered influenza virus haemagglutinin(HA)-derived peptide in collagen-induced arthritis(CIA).CIA was induced in DBA/1 mice by immunisation with type II collagen(CII).Altered HA308-317,wild-type HA308-317 or irrelevant peptide was administered intranasally beginning from arthritis onset.Clinical and histological scores were assessed,and cytokine levels in the serum or supernatants from splenocytes were determined.The percentages of Th1 and Th2 cells in response to different peptides were analysed by FACS both in vivo and in vitro.Our results showed that intranasal administration of altered HA308-317 peptide significantly ameliorated CIA.The therapeutic effect of altered HA308-317 peptide was associated with a substantial decrease in production of interferon(IFN)-c,interleukin(IL)-6,monocyte chemoattractant protein(MCP)-1,anti-CII IgG,IgG1 and IgG2a antibodies,and an markedly increase in production of IL-10 and IL-4 in serum or supernatants from splenocytes treated with altered HA308-317 peptide.The percentage of Th2(CD41IL-41)cells was upregulated significantly by altered HA308-317 peptide with a decreased percentage of Th1(T helper 1;CD41INF-c1)cells both in vivo and in vitro.These findings suggest that altered HA308-317 peptide might be a promising candidate for rheumatoid arthritis(RA)treatment. | Jian Sun Yuan Jia Ru Li Jianping Guo Xiaolin Sun Yanying Liu Yingni Li Haihong Yao Xia Liu Jing Zhao Zhanguo Li | 2011 | Cellular & Molecular Immunology2011，8，4： | 0 |
| 20 | Fabrication of Ceramic-Polymer Piezo-Composites with Triply Periodic Minimal Interfaces via Digital Light Processing显示文摘The geometry of the phase interface in co-continuous piezoelectric composites is critical in improving their piezo-electric properties.However,conventional co-continuous piezoelectric composites are mostly simple structures such as wood stacks or honeycombs,which are prone to stress concentrations at the joints,thus reducing the fatigue service performance and force-electric conversion efficiency of piezoelectric composites.Such simple structures limit further improvements in the overall performance of co-continuous piezoelectric composites.In this study,based on the digital light processing 3D printing method,we investigated the influence of three dif-ferent structures-the gyroid,diamond,and woodpile interfaces-on the piezoelectric and mechanical properties of co-continuous ceramic/polymer piezoelectric composites.These findings demonstrate that the gyroid and di-amond interfaces outperformed the ceramic skeleton of the woodpile interface in terms of both mechanical and electrical properties.When the ceramic volume percentage was 50%,the piezo-composite of the gyroid surface exhibited the greatest hydrostatic figure of merit(HFOM),reaching 4.23×10^(−12) Pa^(−1),and its piezoelectric coeffi-cient(d_(33))and relative dielectric constant(εr)reached 115 pC/N and 748,respectively.The research results lay the foundation for the application of co-continuous piezoelectric composites in underwater communication and detection. | Kai Liu Junchao He Tianyang Li Jiaming Hu Yanying Du Yusheng Shi Chunzhe Yan Zhangwei Chen Shangyu Huang Huajun Sun | 2023 | Chinese Journal of Mechanical Engineering(Additive Manufacturing Frontiers)2023，2，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员