|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Substantial transition to clean household energy mix in rural China显示文摘The household energy mix has significant impacts on human health and climate,as it contributes greatly to many health-and climate-relevant air pollutants.Compared to the well-established urban energy statistical system,the rural household energy statistical system is incomplete and is often associated with high biases.Via a nationwide investigation,this study revealed high contributions to energy supply from coal and biomass fuels in the rural household energy sector,while electricity comprised∼20%.Stacking(the use of multiple sources of energy)is significant,and the average number of energy types was 2.8 per household.Compared to 2012,the consumption of biomass and coals in 2017 decreased by 45%and 12%,respectively,while the gas consumption amount increased by 204%.Increased gas and decreased coal consumptions were mainly in cooking,while decreased biomass was in both cooking(41%)and heating(59%).The time-sharing fraction of electricity and gases(E&G)for daily cooking grew,reaching 69%in 2017,but for space heating,traditional solid fuels were still dominant,with the national average shared fraction of E&G being only 20%.The non-uniform spatial distribution and the non-linear increase in the fraction of E&G indicated challenges to achieving universal access to modern cooking energy by 2030,particularly in less-developed rural and mountainous areas.In some non-typical heating zones,the increased share of E&G for heating was significant and largely driven by income growth,but in typical heating zones,the time-sharing fraction was<5%and was not significantly increased,except in areas with policy intervention.The intervention policy not only led to dramatic increases in the clean energy fraction for heating but also accelerated the clean cooking transition.Higher income,higher education,younger age,less energy/stove stacking and smaller family size positively impacted the clean energy transition. | Guofeng Shen Rui Xiong Yanlin Tian Zhihan Luo Bahabaike Jiangtulu Wenjun Meng Wei Du Jing Meng Yuanchen Chen Bing Xue Bin Wang Yonghong Duan Jia Duo Fenggui Fan Lei Huang Tianzhen Ju Fenggui Liu Shunxin Li Xianli Liu Yungui Li Mu Wang Ying Nan Bo Pan Yanfang Pan Lizhi Wang Eddy Zeng Chao Zhan Yilin Chen Huizhong Shen Hefa Cheng Shu Tao | 2022 | National Science Review2022，9，7： | 4 |
| 3 | δ^(15)N-stable isotope analysis of NH_(x): An overview on analytical measurements, source sampling and its source apportionment显示文摘Agricultural sources and non-agricultural emissions contribute to gaseous ammonia(NH_(3))that plays a vital role in severe haze formation.Qualitative and quantitative contributions of these sources to ambient PM_(2.5)(particulate matter with an aerodynamic equivalent diameter below 2.5µm)concentrations remains uncertain.Stable nitrogen isotopic composition(δ^(15)N)of NH_(3)and NH_(4)+(δ^(15)N(NH_(3))andδ^(15)N(NH_(4)+),respectively)can yield valuable information about its sources and associated processes.This review provides an overview of the recent progress in analytical techniques forδ^(15)N(NH_(3))andδ^(15)N(NH_(4)+)measurement,sampling of atmospheric NH_(3)and NH_(4)+in the ambient air and their sources signature(e.g.,agricultural vs.fossil fuel),and isotope-based source apportionment of NH_(3)in urban atmosphere.This study highlights that collecting sample that are fully representative of emission sources remains a challenge in fingerprintingδ^(15)N(NH_(3))values of NH_(3)emission sources.Furthermore,isotopic fractionation during NH_(3)gas-to-particle conversion under varying ambient field conditions(e.g.,relative humidity,particle pH,temperature)remains unclear,which indicates more field and laboratory studies to validate theoretically predicted isotopic fractionation are required.Thus,this study concludes that lack of refinedδ^(15)N(NH_(3))fingerprints and full understanding of isotopic fractionation during aerosol formation in a laboratory and field conditions is a limitation for isotope-based source apportionment of NH_(3).More experimental work(in chamber studies)and theoretical estimations in combinations of field verification are necessary in characterizing isotopic fractionation under various environmental and atmospheric neutralization conditions,which would help to better interpret isotopic data and our understanding on NH_(x)(NH_(3)+NH_(4)+)dynamics in the atmosphere. | Noshan Bhattarai Shuxiao Wang Yuepeng Pan Qingcheng Xu Yanlin Zhang Yunhua Chang Yunting Fang | 2021 | Frontiers of Environmental Science & Engineering2021，15，6： | 3 |
| 4 | The role of charged multivesicular body protein 5 in programmed cell death in leukemic cells显示文摘人(CHMP5 ) 现代人的控告的 multivesicular 身体蛋白质 5 是 multivesicular 身体的一个成员,它用作 anti-apoptotic 蛋白质并且被认为参予引起白血病。在这研究,一条短发卡的基于 RNA 的 RNA 干扰途径被用来在白血病的房间线 U937 禁止 CHMP5 的表示。在 CHMP5 被禁止以后,抗体 microarray 和西方的污点分析被用来在规划房间死亡(PCD ) 学习变化小径。PCD 能被分类进三种类型:apoptosis,坏死,和 autophagy。结果显示出那 caspase 3 在 CHMP5 缺乏的 U937 房间被激活,显示 apoptotic 小径被激活,尽管既不内在外来的 apoptotic 小径也没被激活。我们的结果也证明 Granzyme B/Perforin apoptotic 小径被 CHMP5 silencing 激活。坏死被 caspase 独立的刽子手激活。在这研究,我们证明导致 apoptosis 调停蛋白质的坏死的 PCD 小径在 CHMP5 抑制以后被激活。autophagic PCD 没发生在 CHMP5 缺乏的 U937 房间,这被发现。在结论,在 CHMP5 抑制,两条 Granzyme B/Perforin apoptotic 小径和导致 apoptosis 以后,调停因素的坏死的小径被激活,当 autophagic 小径没被激活时。 | Hairong Wang Jia Liu Feilong Wang Miao Chen Zhenyu Xiao Renrong OuYang Aihua Fei Yanlin Shen Shuming Pan | 2013 | Acta Biochimica et Biophysica Sinica2013，45，5： | 3 |
| 5 | A new gain-of-function OsGS2/GRF4 allele generated by CRISPR/Cas9 genome editing increases rice grain size and yield显示文摘Grain size is one of the most important factors affecting rice grain quality and yield,and attracts great attention from molecular biologists and breeders.In this study,we engineered a CRISPR/Cas9 system targeting the miR396 recognition site of the rice GS2 gene,which encodes growth-regulating factor 4(OsGRF4)and regulates multiple agronomic traits including grain size,grain quality,nitrogen use efficiency,abiotic stress response,and seed shattering.In contrast to most previous genome editing efforts in which indel mutations were chosen to obtain null mutants,a mutant named GS2^(E) carrying an in-frame 6-bp deletion and 1-bp substitution within the miR396-targeted sequence was identified.GS2^(E) plants showed increased expression of GS2 in consistent with impaired repression by miR396.As expected,the gain-of-function GS2^(E) mutant exhibited multiple beneficial traits including increased grain size and yield and bigger grain length/width ratio.Thousand grain weight and grain yield per plant of GS2^(E) plants were increased by 23.5%and 10.4%,respectively.These improved traits were passed to hybrids in a semidominant way,suggesting that the new GS2^(E) allele has great potential in rice improvement.Taken together,we report new GS2 germplasm and describe a novel gene-editing strategy that can be widely employed to improve grain size and yield in rice.This trait-improvement strategy could be applied to other genes containing miRNA target sites,in particular the conserved miR396-GRF/GIF module that governs plant growth,development and environmental response. | Wenshu Wang Weipeng Wang Yanlin Pan Chao Tan Hongjing Li Ya Chen Xingdan Liu Jing Wei Nian Xu Yu Han Han Gu Rongjian Ye Qi Ding Chonglie Ma | 2022 | The Crop Journal2022，10，4： | 3 |
| 6 | Current-driving intergranular corrosion performance regeneration below the precipitates solvus temperature in Al–Mg alloy显示文摘Heat treatment is an effective method to improve the intergranular corrosion resistance of the sensitized Al–Mg alloy due to dissolution of the grain boundary precipitates above the solvus temperature ofβ-phase.The grain boundary precipitates will grow and coarsening below the solvus temperature.In this study,the in-situ intergranular corrosion performance regeneration of the sensitized Al–Mg alloy can be realized by low-density electro-pulsing treatment below the solvus temperature ofβ-phase.Our findings show that the dissolution of grain boundary precipitates by electro-pulsing treatment is accelerated at relatively low temperature in comparison to traditional heat treatment.The athermal effect produced by the interaction between atoms and electrons on the dissolution of grain boundary precipitates is the main reason for the improved corrosion resistance below the solvus temperature ofβ-phase. | Di Zhang Zhen Zhang Yanlin Pan Yanbin Jiang Linzhong Zhuang Jishan Zhang Xinfang Zhang | 2020 | Journal of Materials Science & Technology2020，52，18： | 3 |
| 7 | Effects of Y2O3 on the microstructure and mechanical properties ofspark plasma sintered fine-grained W-Ni-Mn alloy显示文摘Fine-grained W-Ni-Mn-Y_2 O_3 alloys were fabricated by mechanical alloying-assisted spark plasma sintering(SPS), and the effects of Y_2 O_3 content on the microstructure and mechanical properties of the alloys were studied. Fine-grained 90 W-6 Ni-4 Mn-Y_2 O_3 alloys with uniform microstructure and excellent properties were prepared by SPS at 1150 ℃. The addition of trace Y_2 O_3 inhibited the sintering densification process and refined the W grain size. The average W grain size decreased from 5.5 μm to 2.1 μm.The fracture mode changed from W grain transgranular fracture and W-W interface fracture to W-W and W-Matrix phase interface fracture. The Rockwell hardness and bending strength of alloys initially increased and then decreased with increasing Y_2 O_3 content. The optimum comprehensive mechanical properties(Rockwell hardness and bending strength) of the alloys were obtained at the same time when the mass fraction of Y_2 O_3 was 0.4%. | Yanlin Pan Lei Ding Hui Li Daoping Xiang | 2017 | Journal of Rare Earths2017，35，11： | 1 |
| 8 | Research of Climatic Zoning Index System of Red Cartridge Kiwifruit in Guizhou显示文摘The climate data of 84 meteorological stations in Guizhou from 1981 to 2010 was used,including the statistical data of daily precipitation,temperature,sunshine hours,evaporation,frost free period and so on. Using the equations of light and heat coefficient,light and heat index,latitude and temperature index,active accumulated temperature,effective accumulated temperature,aridity index,and arid-wet index,the red cartridge kiwifruit zoning index of Guizhou was analyzed and studied. The results showed that the zoning index system for the climatic characteristics of Guizhou mountainous area must be established in order to realize the variety regionalization of red cartridge kiwifruit in Guizhou mountainous area,and ten climatic factors were taken as climatic zoning indexes of red cartridge kiwifruit planting,including active accumulated temperature,effective accumulated temperature,annual average temperature,average temperature of July,light and heat coefficient,light and heat index,latitude and temperature index,frost free period,aridity index and arid-wet index. These indicators were giving a comprehensive evaluation for climate suitability conditions of red cartridge kiwifruit planting,and providing the scientific and reasonable basis for the promotion planting of red cartridge kiwifruit in mountain area of Guizhou. | Chi Zaixiang Xiao Yanlin Li Guiqiong Liu Lijuan Pan Xuyan Gong Xueqin | 2017 | Meteorological and Environmental Research2017，8，6： | 1 |
| 9 | Transpiration-inspired Capillary for Synchronous Synthesis and Patterning of Silver Nanoparticles显示文摘Traditional synthesis strategy of nanomaterials with complicated process and high cost limits their applications.Here,we propose a facile process for the synchronous synthesis and patterning of silver nanoparticles(Ag NPs)through the self-driven microchannel reactor with the capillary effect inspired by transpiration.The evaporation contributes to capillary and accumulation effects in the microchannels.The silver reactant-containing droplets can be spontaneously divided and distributed in multiple microchannels during the whole fabrication process by the capillary effect.The newly formed Ag NPs at the gas-liquid interface can be assembled on both sides of the microchannels by the accumulation effect.The capillary effect decreases the disturbances,which ensures the uniformity of the patterning.By the combination of microchannels with different widths,various Ag NPs-assembled patterns with stable electrical properties are achieved.This efficient strategy with a simple fabrication procedure is towards the technological engineering of nanoscale architected materials. | CHEN Bingda ZHANG Zelong SU Meng QIN Feifej PAN Qi XIE Daixi YANG Xu ZHANG Kun ZHANG Zeying XIE Hongfei CARMELIET Jan SONG Yanlin | 2023 | Chemical Research in Chinese Universities2023，39，1： | 0 |
| 10 | One droplet reaction for synthesis of multi-sized nanoparticles显示文摘Reaction kinetics of nanoparticles can be controlled by tuning the Peclet number(Pe)as it is an essential parameter in synthesis of multi-sized nanoparticles.Herein,we propose to implement a self-driven multi-dimension microchannels reactor(MMR)for the one droplet synthesis of multi-sized nanoparticles.By carefully controlling the Pe at the gas-liquid interface,the newly formed seed crystals selectively accumulate and grow to a specific size.By the combination of microchannels of different widths and lengths,one droplet reaction in the same apparatus achieves the synchronous synthesis of diverse nanoparticles.MMR enables precise control of nanoparticle diameter at 5 nm precision in the range of 10-110 nm.The use of MMR can be extended to the synthesis of uniform Ag,Au,Pt,and Pd nanoparticles,opening towards the production and engineering of nanostructured materials.This approach gives the chance to regulate the accumulation probability for precise synthesis of nanoparticles with different diameters. | Bingda Chen Feifei Qin Meng Su Daixi Xie Zeying Zhang Qi Pan Huadong Wang Xu Yang Sisi Chen Jingwei Huang Dominique Derome Jan Carmeliet Yanlin Song | 2023 | Nano Research2023，16，4： | 0 |
| 11 | Tunable Fluid-Type Metasurface for Wide-Angle and Multifrequency Water-Air Acoustic Transmission显示文摘Efficient acoustic communication across the water-air interface remains a great challenge owing to the extreme acoustic impedance mismatch.Few present acoustic metamaterials can be constructed on the free air-water interface for enhancing the acoustic transmission because of the interface instability.Previous strategies overcoming this difficulty were limited in practical usage,as well as the wide-angle and multifrequency acoustic transmission.Here,we report a simple and practical way to obtain the wide-angle and multifrequency water-air acoustic transmission with a tunable fluid-type acoustic metasurface(FAM).The FAM has a transmission enhancement of acoustic energy over 200 times,with a thickness less than the wavelength in water by three orders of magnitude.The FAM can work at an almost arbitrary water-to-air incident angle,and the operating frequencies can be flexibly adjusted.Multifrequency transmissions can be obtained with multilayer FAMs.In experiments,the FAM is demonstrated to be stable enough for practical applications and has the transmission enhancement of over 20 dB for wide frequencies.The transmission enhancement of music signal across the water-air interface was performed to demonstrate the applications in acoustic communications.The FAM will benefit various applications in hydroacoustics and oceanography. | Zhandong Huang Shengdong Zhao Yiyuan Zhang Zheren Cai Zheng Li Junfeng Xiao Meng Su Qiuquan Guo Chuanzeng Zhang Yaozong Pan Xiaobing Cai Yanlin Song Jun Yang | 2022 | Research2022，，1： | 0 |
| 12 | Smartphone-based rapid and visual pathological diagnosis of glioma using perovskite probes显示文摘Histopathology plays a great role in diagnosing various diseases,which is considered as a golden standard for tumor identification.The tissue constituents must be stained by visible labels for microscopic analysis by medical experts.However,this process is time-consuming,labor-intensive,and expensive,which requires rapid pathological approaches for diagnosis in the operating room.Here,we present an easy-to-process and high-performance perovskite biological probes for rapid and visual pathological diagnosis of glioma.Perovskite quantum dots can be encapsulated by the copolymer into nanocrystals(PNCs)with a diameter of 100 nm,which is modified with chlorotoxin to achieve the specific recognition of glioma.Benefiting from the super photoluminescence quantum yield(above 93%)of EVA@PNCs aqueous solution,the glioma can be clearly imaged and captured via a smartphone under the excitation of a handheld UV lamp.To demonstrate the visualization and efficiency of PNC probes,different malignant grades of brain tumor sections can be distinguished in no more than 5 min.This strategy provides a general auxiliary diagnosis platform for achieving the histopathology analysis near the operating bed,which is currently not feasible with standard histochemical staining methods. | Dongdong Wu Jimei Chi Junzhen Fan Lijun Cheng Xuning Wang Xu Yang Meng Zhang Zewei Lian Zengqi Huang Huadong Wang Hongfei Xie Sisi Chen Qi Pan Zeying Zhang Bingda Chen Guochen Sun Bainan Xu Meng Su Yanlin Song | 2023 | InfoMat2023，5，11： | 0 |
| 13 | Rapid Path Extraction and Three-Dimensional Roaming of the Virtual Endonasal Endoscope显示文摘Compared with traditional endonasal endoscope,Virtual endonasal endoscope(VEE)is a computerized alternative solution with the advantages of being non-invasive,affordable,no perforation,low risk of infection,and high degree of sensitivity.A Central path extraction algorithm based on Pre-planning of the roaming area(CPE-PRA)is proposed to extract the central path of the nasal cavity model efficiently.And a B-spline curve fitting algorithm based on Relative center deviation(RCD)is introduced to fit a smooth curve to the extracted path,so that the virtual camera could have both a steady turning speed and a broad vision.A series of comparison tests were conducted to evaluate the effectiveness and efficiency of the proposed algorithms. | WANG Yudong HAN Jing PAN Junjun WANG Jing CAO Yi ZHU Li LUO Yanlin | 2021 | Chinese Journal of Electronics2021，30，3： | 0 |
| 14 | Poly(lactic acid)-aspirin microspheres prepared via the traditional and improved solvent evaporation methods and its application performances显示文摘Drug-loaded microspheres are significant for the development of modern pharmaceutical products. It is well known that the taken of aspirin for long-term increases the risk of serious gastrointestinal complications, therefore a controllable delivery of aspirin is of importance to lighten those side effects. In this work, poly(lactic acid)(PLA) was chosen as the carrier to prepare PLA-aspirin microspheres by using the traditional and the improved solvent evaporation methods. It was found that no matter which experimental condition was, the encapsulation efficiency of aspirin was higher by using the improved method than that of the traditional method. Specifically, when the concentration of polyvinyl alcohol = 1%(mass),the polymer concentration = 1:20, the oil/water rate = 1:2.5, PLA-aspirin microspheres were obtained via the improved method with a high yield of 82.83%(mass) and an encapsulation efficiency of 44.09%. PLAaspirin microspheres were then prepared continuously using the improved method, which further enhanced the encapsulation efficiency to 54.56%. Approximate 85% aspirin released from microspheres within 7 days. Obvious degradation which was represented by reduction on hardness was observed by soaking microspheres in PBS for 60 days. This work is of interest because it provides a continuous route to prepare PLA-aspirin microspheres continuously with a high drug encapsulation efficiency. | Xiaolin Pan Mengyuan Gao Yun Wang Yanping He Tian Si Yanlin Sun | 2023 | Chinese Journal of Chemical Engineering2023，60，8： | 0 |
| 15 | Mechanical properties,corrosion behavior and microstructure evolution of zinc and scandium co-strengthened 5xxx alloy显示文摘Nowadays,it is a challenge to improve the strength of 5xxx aluminium alloy while maintaining its distinctive properties.To address this,the Zn and Sc modified high strength 5xxx aluminium alloys with good intergranular corrosion resistance were prepared through chill casting,and the effects of minor Sc on mechanical properties,corrosion behavior and microstructure evolution of Al-5.0Mg-3.0Zn alloys were systematically investigated.The results show that the Sc containing alloy has high number density and small size of intragranular precipitates,combined with the solid solution strengthening of Sc and the Al_(3)(Sc_(1-x),Zr_(x))second phase strengthening,the strength of Al-5.0Mg-3.0Zn-0.1Sc alloy is obviously enhanced.Meanwhile,the intergranular corrosion resistance of the Sc containing alloy is also improved due to the formation of a large number of low angle grain boundaries and the weakening of the continuity of precipitated phases along the grain boundaries. | Yanlin Pan Yue Xu Di Zhang Jishan Zhang Guxin Zhou Yujing Lang | 2023 | Journal of Rare Earths2023，41，11： | 0 |
| 16 | Single-cell RNA sequencing reveals the developmental program underlying proximal–distal patterning of the human lung at the embryonic stage显示文摘The lung is the primary respiratory organ in human, in which the proximal airway and the distal alveoli are responsible for air conduction and gas exchange, respectively. However, the regulation of proximal–distal patterning at the embryonic stage of human lung development is largely unknown. Here we investigated the early lung development of human embryos at weeks 4–8 post fertilization (Carnegie stages 12–21) using single-cell RNA sequencing, and obtained a transcriptomic atlas of 169,686 cells. We observed discernible gene expression patterns of proximal and distal epithelia at week 4, upon the initiation of lung organogenesis. Moreover, we identified novel transcriptional regulators of the patterning of proximal (e.g., THRB and EGR3) and distal (e.g., ETV1 and SOX6) epithelia. Further dissection revealed various stromal cell populations, including an early-embryonic BDNF+ population, providing a proximal–distal patterning niche with spatial specificity. In addition, we elucidated the cell fate bifurcation and maturation of airway and vascular smooth muscle progenitor cells at the early stage of lung development. Together, our study expands the scope of human lung developmental biology at early embryonic stages. The discovery of intrinsic transcriptional regulators and novel niche providers deepens the understanding of epithelial proximal–distal patterning in human lung development, opening up new avenues for regenerative medicine. | Shangtao Cao Huijian Feng Hongyan Yi Mengjie Pan Lihui Lin Yao Santo Zhang Ziyu Feng Weifang Liang Baomei Cai Qi Li Zhi Xiong Qingmei Shen Minjing Ke Xing Zhao Huilin Chen Qina He Mingwei Min Quanyou Cai He Liu Jie Wang Duanqing Pei Jiekai Chen Yanlin Ma | 2023 | Cell Research2023，33，6： | 0 |
| 17 | Biallelic variants in RBM42 cause a multisystem disorder with neurological,facial,cardiac,and musculoskeletal involvement显示文摘Here,we report a previously unrecognized syndromic neurodevelopmental disorder associated with biallelic loss-of-function variants in the RBM42 gene.The patient is a 2-year-old female with severe central nervous system(CNs)abnormalities,hypotonia,hearing loss,congenital heart defects,and dysmorphic facial features.Familial whole-exome sequencing(WEs)reveals that the patient has two compound heterozygous variants,c.304C>T(p.R102*)and c.1312G>A(p.A438T),in the RBM42 gene which encodes an integral component of splicing complex in the RNA-binding motif protein family.The p.A438T variant is in the RRM domain which impairs RBM42 pro-tein stability in vivo.Additionally,p.A438T disrupts the interaction of RBM42 with hnRNP K,which is the causa-tive gene for Au-Kline syndrome with overlapping disease characteristics seen in the index patient.The human R102*or A438T mutant protein failed to fully rescue the growth defects of RBM42 ortholog knockout△FgRbp1 in Fusarium while it was rescued by the wild-type(WT)human RBM42.A mouse model carying Rbm42 compound heterozygous variants,c.280C>T(p.Q94*)and c.1306_1308delinsACA(p.A436T),demonstrated gross fetal develop-mental defects and most of the double mutant animals died by E13.5.RNA-seq data confirmed that Rbm42 was involved in neurological and myocardial functions with an essential role in alternative splicing(As).Overall,we present clinical,genetic,and functional data to demonstrate that defects in RBM42 constitute the underlying etiology of a new neurodevelopmental disease which links the dysregulation of global AS to abnormal embryonic development. | Yiyao Chen Bingxin Yang Xiaoyu Merlin Zhang Songchang Chen Minhui Wang Liya Hu Nina Pan Shuyuan Li Weihui Shi Zhenhua Yang Li Wang Yajing Tan Jian Wang Yanlin Wang Qinghe Xing Zhonghua Ma Jinsong Li He-Feng Huang Jinglan Zhang Chenming Xu | 2024 | Protein & Cell2024，15，1： | 0 |
| 18 | Nanoparticle-induced drag reduction for polyacrylamide in turbulent flow with high Reynolds numbers显示文摘Although having been increasingly studied, there is still controversy as to when the addition of nanoparticles could improve the drag reduction performance of polymer drag reducer and particularly what is the underlying mechanism from the fluid dynamics viewpoint. The drag reduction effects of adding SiO_(2) nanoparticles to various polymer polyacrylamide(PAM) solutions were examined in this work.The optimal combination of SiO_(2) nanoparticles with cationic polyacrylamide was confirmed.Interestingly,the addition of SiO_(2) nanoparticles to cationic polyacrylamide solution was shown to be quite efficient for reducing drag, but only at higher flow rates with Reynolds numbers more than 6000, below which the nanoparticle addition is even negative. The addition of SiO_(2) nanoparticles to the PAM solution is supposed to play a dual role. The first is an increase in flow resistance caused by the Brownian motion of nanoparticles, while the second is a decrease in flow resistance caused by acting as nodes to protect the polymer chain from shear-induced breaking under high shear action. At optimal nanoparticle concentration and under higher Reynolds numbers, the later effect is dominant, which could improve the drag reduction performance of polymer drag reducers. Our work should serve as a guide for the application of natural gas fracturing, where the flow rate is frequently very high. | Xiaoping Li Jiaxin Pan Jinwen Shi Yanlin Chai Songwei Hu Qiaorong Han Yanming Zhang Xianwen Li Dengwei Jing | 2023 | Chinese Journal of Chemical Engineering2023，56，4： | 0 |
| 19 | Tunable Fluid-Type Metasurface for Wide-Angle and Multifrequency Water-Air Acoustic Transmission显示文摘Efficient acoustic communication across the water-air interface remains a great challenge owing to the extreme acoustic impedance mismatch.Few present acoustic metamaterials can be constructed on the free air-water interface for enhancing the acoustic transmission because of the interface instability.Previous strategies overcoming this difficulty were limited in practical usage,as well as the wide-angle and multifrequency acoustic transmission.Here,we report a simple and practical way to obtain the wide-angle and multifrequency water-air acoustic transmission with a tunable fluid-type acoustic metasurface(FAM).The FAM has a transmission enhancement of acoustic energy over 200 times,with a thickness less than the wavelength in water by three orders of magnitude.The FAM can work at an almost arbitrary water-to-air incident angle,and the operating frequencies can be flexibly adjusted.Multifrequency transmissions can be obtained with multilayer FAMs.In experiments,the FAM is demonstrated to be stable enough for practical applications and has the transmission enhancement of over 20 dB for wide frequencies.The transmission enhancement of music signal across the water-air interface was performed to demonstrate the applications in acoustic communications.The FAM will benefit various applications in hydroacoustics and oceanography. | Zhandong Huang Shengdong Zhao Yiyuan Zhang Zheren Cai Zheng Li Junfeng Xiao Meng Su Qiuquan Guo Chuanzeng Zhang Yaozong Pan Xiaobing Cai Yanlin Song Jun Yang | 2021 | Research2021，，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员