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| 1 | Malnutrition and Quality of Life in Chinese Cancer Patients: a Clinical Study of 23,994 Subjects显示文摘Background Malnutrition is common in patients with cancer,and can negatively impact their quality of life(QoL)and even survival.However,there is currently no large data available on the prevalence of malnutrition in Chinese cancer patients.This study evaluated the prevalence of malnutrition and the QoL of Chinese patients with locoregional,recurrent or metastatic cancer.Methods We conducted a nationwide observational,multi-center,hospital-based cross-sectional study within the Chinese Society of Nutritional Oncology(CSNO)Network.All of the patients were diagnosed with one of the following 18 different types of malignant tumors:lung cancer,gastric cancer,liver cancer,colorectal cancer,breast cancer,esophageal cancer,cervical cancer,endometrial cancer,nasopharyngeal carcinoma,malignant lymphoma,leukemia,pancreatic cancer,ovarian cancer,prostate cancer,bladder cancer,brain cancer,biliary tract malignant tumors or gastrointestinal stromal tumors.These patients were enrolled from 72 hospitals located in different regions of China.The patients’nutritional status was evaluated based on the body mass index(BMI),loss of bodyweight,laboratory measurements and patient generated-subjective global assessment(PG-SGA)scores.The cancer patients’physical status and QoL were assessed by the Karnofsky Performance Status(KPS)questionnaire and the European Organization for Research and Treatment of Cancer(EORTC)QLQ-C30 questionnaire,respectively.Results From December 2013 to April 2016,23,994 patients hospitalized for cancer treatment(such as surgery,chemotherapy or radiotherapy)were enrolled in the study.The patients included 12,494(52.9%)males and 11,124(47.1%)females.The mean age was 55.8±13.7 years.The proportions of patients in cancer stagesⅠ,Ⅱ,Ⅲ,Ⅳand uncertain were 11.5%,20.3%,27.5%,30.2%and 10.5%,respectively.Among the 23,994 inpatients,the proportions of patients who were underweight(BMI<18.5 kg/m2),normal(18.5 kg/m2 | Hong Xia Xu Chun Hua Song Zhen Ming Fu Chang Wang Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Fu Xiang Zhou Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Min Weng Qing Hua Yao Jiu Wei Cui Wei Li Han Ping Shi the Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group | 2021 | Journal of Nutritional Oncology2021，6，1： | 8 |
| 2 | Extension Protocol for the Investigation on Nutrition Status and Clinical Outcome of Patients with Common Cancers in China(INSCOC)Study:2021 update显示文摘Background Malnutrition is common in patients with cancer,and this adversely affects the survival and quality of life of patients.Chinese Society for Nutritional Oncology issued a multi-center,large-scale,long-term follow-up prospective study,the Investigation on Nutrition Status and Clinical Outcome of Patients with Common Cancers in China(INSCOC study)since 2013.This is an extension to the previous 2013-2020 study protocol.This study still sought to:①address the prognostic impact of nutritional factors and quality of life on cancer patient survival;②describe the overall and cancer-specific incidence and/or distribution of malnutrition and different measurements of patient quality of life.Methods and study design This is an observational,multi-centered,hospital-based prospective cohort study.Data collection will be performed at baseline(within 48 hours after patient admission),during the hospital stay and 30 days after hospital admission.Follow-up will be conducted for 1-20 years after enrollment.The primary outcome will be the all-cause mortality/overall survival,and secondary outcomes will be the length of hospital stay and costs of hospitalization.Study factors will include demographic characteristics,tumor characteristics,information about chronic diseases,hematological measurements(e.g.,red blood cell count,total lymphocyte counts,hemoglobin,albumin,prealbumin,creatinine,C-reactive protein,IL-6),anthropometric measurements(e.g.,height,weight,arm circumference,arm muscle circumference,triceps skinfold thickness,and waist circumference),body composition parameters,PG-SGA scores,quality of life(as indicated by the QLQ-C30 questionnaire),muscle mass(as indicated by the calf circumference),muscle strength(as indicated by the handgrip strength),muscle function(as indicated by the six-meter walking speed test)and physical status assessments(as indicated by the Karnofsky Performance Status scores).This clinical study protocol was approved by local Ethics Committees of all the participating hospitals.Written informed consent is required for each subject included.Discussion This multi-center,large-scale,long-term follow up prospective study will help improve the diagnosis of malnutrition in cancer patients and identify the risk factors associated with adverse clinical outcomes.The anticipated results of this study will highlight the need for a truly scientific appraisal of nutrition therapy in Chinese oncology populations,and finally help treat the potentially reversible elements of malnutrition in cancer patients to improve their clinical outcomes in the future. | Hong Xia Xu Chun Hua Song Liang Yu Yin Chang Wang Zhen Ming Fu Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Fu Xiang Zhou Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Zhi Kang Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Xiang Hua Wu Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Min Weng Qing Hua Yao Ya Yin Yu Quan Jun Lyu Hong Qiu Ming Liu Wei Li Han Ping Shi The Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group | 2022 | Journal of Nutritional Oncology2022，7，2： | 3 |
| 3 | Electrolyte Concentration Regulation Boosting Zinc Storage Stability of High-Capacity K0.486V2O5 Cathode for Bendable Quasi-Solid-State Zinc Ion Batteries显示文摘Vanadium-based cathodes have attracted great interest in aqueous zinc ion batteries(AZIBs)due to their large capacities,good rate performance and facile synthesis in large scale.However,their practical application is greatly hampered by vanadium dissolution issue in conventional dilute electrolytes.Herein,taking a new potassium vanadate K0.486V2O5(KVO)cathode with large interlayer spacing(~0.95 nm)and high capacity as an example,we propose that the cycle life of vanadates can be greatly upgraded in AZIBs by regulating the concentration of ZnCl2 electrolyte,but with no need to approach“water-in-salt”threshold.With the optimized moderate concentration of 15 m ZnCl2 electrolyte,the KVO exhibits the best cycling stability with ~95.02% capacity retention after 1400 cycles.We further design a novel sodium carboxymethyl cellulose(CMC)-moderate concentration ZnCl2 gel electrolyte with high ionic conductivity of 10.08 mS cm^-1 for the first time and assemble a quasi-solid-state AZIB.This device is bendable with remarkable energy density(268.2 Wh kg^−1),excellent stability(97.35% after 2800 cycles),low self-discharge rate,and good environmental(temperature,pressure)suitability,and is capable of powering small electronics.The device also exhibits good electrochemical performance with high KVO mass loading(5 and 10 mg cm^-2).Our work sheds light on the feasibility of using moderately concentrated electrolyte to address the stability issue of aqueous soluble electrode materials. | Linpo Li Shuailei Liu Wencong Liu Deliang Ba Wenyi Liu Qiuyue Gui Yao Chen Zuoqi Hu Yuanyuan Li Jinping Liu | 2021 | Nano-Micro Letters2021，13，2： | 2 |
| 4 | Current management of chemotherapy-induced neutropenia in adults:key points and new challenges显示文摘Chemotherapy-induced neutropenia(CIN)is a potentially fatal and common complication in myelosuppressive chemotherapy.The timing and grade of CIN may play prognostic and predictive roles in cancer therapy.CIN is associated with older age,poor functional and nutritional status,the presence of significant comorbidities,the type of cancer,previous chemotherapy cycles,the stage of the disease,specific chemotherapy regimens,and combined therapies.There are many key points and new challenges in the management of CIN in adults including:(1)Genetic risk factors to evaluate the patient’s risk for CIN remain unclear.However,these risk factors urgently need to be identified.(2)Febrile neutropenia(FN)remains one of the most common reasons for oncological emergency.No consensus nomogram for FN risk assessment has been established.(3)Different assessment tools[e.g.,Multinational Association for Supportive Care in Cancer(MASCC),the Clinical Index of Stable Febrile Neutropenia(CISNE)score model,and other tools]have been suggested to help stratify the risk of complications in patients with FN.However,current tools have limitations.The CISNE score model is useful to support decision-making,especially for patients with stable FN.(4)There are still some challenges,including the benefits of granulocyte colony stimulating factor treatment and the optimal antibiotic regimen in emergency management of FN.In view of the current reports,our group discusses the key points,new challenges,and management of CIN. | Committee of Neoplastic Supportive-Care(CONS),China Anti-Cancer Association Committee of Clinical Chemotherapy,China Anti-Cancer Association Yi Ba Yuankai Shi Wenqi Jiang Jifeng Feng Ying Cheng Li Xiao Qingyuan Zhang Wensheng Qiu Binghe Xu Ruihua Xu Bo Shen Zhiguo Luo Xiaodong Xie Jianhua Chang Mengzhao Wang Yufu Li Yuerong Shuang Zuoxing Niu Bo Liu Jun Zhang Li Zhang Herui Yao Conghua Xie Huiqiang Huang Wangjun Liao Gongyan Chen Xiaotian Zhang Hanxiang An Yanhong Deng Ping Gong Jianping Xiong Qinghua Yao Xin An Cheng Chen Yanxia Shi Jialei Wang Xiaohua Wang Zhiqiang Wang Puyuan Xing Sheng Yang Chenfei Zhou | 2020 | Cancer Biology & Medicine2020，17，4： | 2 |
| 5 | miRNA27a Is a Biomarker for Predicting Chemosensitivity and Prognosis in Metastatic or Recurrent Gastric Cancer显示文摘 | Dingzhi Huang Haiyan Wang Rui Liu Hongli Li Shaohua Ge Ming Bai Ting Deng Guangyu Yao Yi Ba | 2014 | J. Cell. Biochem2014，，3： | 2 |
| 6 | Effects of Carbonation on Micro Structures of Hardened Cement Paste显示文摘In order to investigate the effects of carbonation on the microstructure of cement concrete,the carbonation depth and microstructure of cement paste with 0.3,0.4 and 0.5 water/cement ratio after 7,14,21 and 28 d accelerated carbonation were studied respectively.The results showed that with the increase of waterto-cement ratio and carbonation age,the carbonation depth was deepened with faster early carbonation speed and slower later carbonation rate.Carbonation densified the structure of hardened cement stone with refinement of pore structure and reduced porosity.Then,during the carbonation process from the surface to the inside of carbonation area,it was prone to form micro-cracks extending to the interior specimen,resulting in cement paste carbonation depth uneven.It is further illustrated that the color reaction method using phenolphthalein solution combined with X-CT and X-ray diffraction analysis is much more reasonable to evaluate the cement concrete carbonation degree.Moreover,during carbonation process sulfur element in cement paste migrated to the area un-carbonated and the concentrated shape of sulfur element is consistent with the coloring region in carbonation interface.Finally it was identified that carbonation not only reduced the p H value in cement concrete but also made prone to crack in carbonation zone,which increased the probability of reinforcement corrosion. | 柳俊哲 yao senyuan ba mingfang he zhimin 李玉顺 | 2016 | Journal of Wuhan University of Technology(Materials Science)2016，31，1： | 2 |
| 7 | Prevale nee and spatial distribution patterns of human echinococcosis at the township level in Sichuan Province, China显示文摘Background:Echinococcosis is a global zoonotic parasitic disease caused by Echinococcus larvae.This disease is highly endemic in Sichuan Province,China.This study investigates the prevalence and spatial distribution characteristics of human echinococcosis at the township level in Sichuan Province,geared towards providing a future reference for the development of precise prevention and control strategies. | Wei He Li-Ying Wang Wen-Jie Yu Guang-Jia Zhang Bo Zhong Sha Liao Qi Wang Rui-Rui Li Liu Yang Ren-Xin Yao Yang Liu Zeli Dan ba Sheng-Chao Qin Shi-An Wang Yan-Xia Wang Yan Huang Qian Wang | 2021 | Infectious Diseases of Poverty2021，10，3： | 2 |
| 8 | Serum MicroRNA Expression Profile as a Biomarker in the Diagnosis and Prognosis of Pancreatic Cancer显示文摘 | Liu Rui Chen Xi Du Yiqi Yao Weiyan Shen Lin Wang Cheng Hu Zhibin Zhuang Rui Ning Guang Zhang Chunni Yuan Yaozong Li Zhaoshen Zen Ke Ba Yi Zhang Chen-Yu | 2012 | Clinical Chemistry2012，，3： | 2 |
| 9 | Jagged-1-mediated activation of notch signalling induces adipo-genesis of adipose-derived stem cells显示文摘 | Ba K Yang X Wu L Wei X Fu N Fu Y Cai X Yao Y Ge Y Lin Y | | 0，，： | 1 |
| 10 | Osteogenic differentiation of adipose-derived stem cells prompted by low-intensity pulsed ultrasound显示文摘 | Yue Y Yang X Wei X Chen J Fu N Fu Y Ba K Li G Yao Y Liang C Zhang J Cai X Wang M | | 0，，： | 1 |
| 11 | The Toll-interleu-kin-1 receptor member SIGIRR regulates colonic epithelialhomeostasis, inflammation, and tumorigenesis显示文摘 | Xiao H Gulen MF Qin J Yao J Bulek K Kish D Altun-tas CZ Wald D Ma C Zhou H Tuohy VK Fairchild RL de la Motte C Cua D Vallance BA Li X | 2007 | Immuni-ty2007，26，4： | 1 |
| 12 | Double-porosity rock model and squirt flow in the laboratory frequency band显示文摘 | Ba J Cao H Yao F C | | 0，，04： | 1 |
| 13 | Synthesis of ethyltert-butylether from tert-butyl alcohol and ethanol on Strong acid cation-exchange resins 显示文摘 | Yang bo lun Yang san ba Yao rui qing | 2000 | Reactive and Functional Polymers2000，44，2： | 1 |
| 14 | Velocity dispersion of P waves in sand-stone and carbonate:double-porosity and local fluid flow theory显示文摘 | Ba J Cao H Yao F C | 2010 | SEG Expanded Abstracts2010，29，： | 1 |
| 15 | A multicentre randomised trial comparing weekly paclitaxel<ce:hsp sp='0.25'/>+<ce:hsp sp='0.25'/>S-1 with weekly paclitaxel<ce:hsp sp='0.25'/>+<ce:hsp sp='0.25'/>5-fluorouracil for patients with advanced gastric cancer显示文摘 | Dingzhi Huang Yi Ba Jianping Xiong Nong Xu Zhao Yan Zhixiang Zhuang Zhuang Yu Huiping Wan Yang Zhang Ting Deng Rongsheng Zheng Zengqing Guo Chunhong Hu Meiling Wang Zhonghe Yu Yang Yao Jichang Meng | 2013 | European Journal of Cancer2013，，： | 1 |
| 16 | Transplantation of adult mouse iPS cell-derived photoreceptorprecursors restores retinal structure and function in degenera-tive mice显示文摘 | Tucker BA Park IH Qi SD Klassen HJ Jiang C Yao J | 2011 | PLoS One2011，6，4： | 1 |
| 17 | Post-marketing Surveillance for Combined Oral Contraceptive Containing Desogestrel(Marvelon~) in Chinese Rural Areas显示文摘Objective To assess the side effects and the continuation rate of combined oral contraceptive(COC) containing desogestrel(Marvelon) during 12 months. Methods This was a post-marketing surveillance study on Marvelon COC among 870 healthy rural women in 5 different counties of Jiangsu Province during 12 months. Results About 24.02% of the women who used Marvelon COC experienced side effects during 12 months. Gastrointestinal disorder,bleeding/spotting and chloasma were ranked the first three in the side effects. The rate of side effects of Marvelon COC users during the first 3 months in southern area of Jiangsu was significantly higher than that of users in northern area of Jiangsu. Most of the users did not experience obvious weight changes i.e.,loss or increase in weight of more than 5 kg during 12 months. Blood pressure and biochemical indicators of almost 99% amongusers were within the normal range. The gross cumulative continuation rate for 12 months was 83.14%;the most common medical reason for discontinuation was gastrointestinal disorder. There was an increased risk of discontinuation use among women with lower educational level. Conclusion Marvelon COC brought fewer side effects and was well accepted when applied in Chinese rural women. | Hong-yan TANG Ying LI Yu-lin WU Jian ZHOU Lei BA Xiao-ping GU Wei-dong WANG Hui YAO Nai-xiu REN Jian-hong CHEN Lian-fang XU | 2008 | Journal of Reproduction and Contraception2008，19，4： | 1 |
| 18 | Retinol binding protein 4 expression in humans:relationship to insulin resistance,inflammation,and response to pioglitazone显示文摘 | Yao BA Varma V Bodies AM | 2007 | J Clin Endocrinol Metab2007，92，7： | 1 |
| 19 | Treatment of hypertrophic osteoar- thropathy with zoledronic acid:case report and review of the literature显示文摘 | Jayakar BA Abelson AG Yao Q | 2011 | Semin Arthritis Rheum2011，41，2： | 1 |
| 20 | Study on the in vitro cultivation of Babesia from buffaloes 显示文摘 | Zhao JL Liu ZL Yao BA | 1997 | Trop Anim Hlth Prod1997，29，4： | 1 |
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