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| 1 | Paleomagnetic data from Early Cretaceous volcanic rocks of West Liaoning:Evidence for intracontinental rotation显示文摘Detailed rock magnetic studies of 55 lavas from Yixian and Fuxin area, West Liaoning, show the primary carriers of remanence to be pseudo-single domain ti-tanomagnetite. K/Ar dating indicates that the volcanic sequence spans 93 to 133 Ma. Stepwise thermal demagnetization successfully isolated well-defined characteristic magnetization (ChRM) in all lavas thermal-treated above 250℃ The mean paleodirections are D/I=5.9°/58.8° (α95 = 2.9°) and D/I =179.2°/-59.9° (α95 = 5.2°) for 27 normally magnetized flows and 28 reversibly magnetized flows, respectively. It indicates that since the Early Cretaceous there is no significant horizontal movement and rotation between the Yixian-Fuxin area and Eurasia. However, Korea Peninsula may have undergone a clockwise rotation of 33.9° relative to the Yixian-Fuxin area during the Cretaceous. On the basis of characteristics of hotspot origins (core-mantle boundary or upper mantle), the clockwise rotation of Korea Peninsula relative to Eurasia is assumed to be | ZHU Rixiang SHAO Ji’an PAN Yongxin SHI Ruiping SHI Guanghai LI Darning | 2002 | Chinese Science Bulletin2002，47，21： | 31 |
| 2 | SIMS U-Pb zircon age of a tuff layer in the Meishucun section, Yunnan, southwest China: Constraint on the age of the Precambrian-Cambrian boundary显示文摘Determination of the age of the Precambrian-Cambrian boundary is critical in understanding early evolution of life on Earth. SIMS U-Pb zircon analyses of the Bed 5 tuff layer of the Meishucun section were carried out closely following the guidance of cathodoluminescence images, and the majority of analyses were conducted on the oscillatory zircon grains. Thirteen measurements yield a highly reliable Concordia U-Pb age of 536.7 ± 3.9 Ma for the Bed 5 horizon. A grand mean of 206Pb/238U age of 535.2± 1.7 Ma (MSWD = 0.53) is calculated based on 13 concordant SIMS measurements of this study and 4 nano-SIMS measurements of Sawaki et al., which is the best estimate of the deposition age of the tuff layer within Bed 5 in the Meishucun section. This age has provided a robust age constraint on the significant Precambrian-Cambrian boundary strata in southern China, which independently suggested the placement of the Precambrian-Cambrian boundary at the bottom of the Xiaowaitoushan Member (Marker A). | RiXiang Zhu XianHua Li XianGuang Hou YongXin Pan Fei Wang ChengLong Deng HuaiYu He | 2009 | Science China Earth Sciences2009，52，9： | 24 |
| 3 | Scattering of SH waves induced by a symmetrical V-shaped canyon: a unified analytical solution显示文摘This paper reports a series solution of wave functions for two-dimensional scattering and diffraction of plane SH waves induced by a symmetrical V-shaped canyon with different shape ratios. A half-space with a symmetrical V-shaped canyon is divided into two sub-regions by using a circular-arc auxiliary boundary. The two sub-regions are represented by global and local cylindrical coordinate systems, respectively. In each coordinate system, the wave field satisfying the Helmholtz equation is represented by the separation of variables method, in terms of the series of both Bessel functions and Hankel functions with unknown complex coefficients. Then, the two wave fields are described in the local coordinate system using the Graf addition theorem. Finally, the unknown coefficients are sought by satisfying the continuity conditions of the auxiliary boundary. To consider the phase characteristics of the wave scattering, a parametric analysis is carried out in the time domain by assuming an incident signal of the Ricker type. Surface and subsurface transient responses demonstrate the characteristics and mechanisms of wave propagating and scattering. | Zhang Ning Gao Yufeng Li Dayong Wu Yongxin Zhang Fei | 2012 | Earthquake Engineering and Engineering Vibration2012，11，4： | 19 |
| 4 | 晚期非小细胞肺癌免疫检查点抑制剂新型生物标志物:血液PD-L1动态检测显示文摘背景免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)具有良好疗效已成为恶性肿瘤治疗领域备受瞩目的翘楚。然而,仅有小部分患者获得长期临床获益。如何选择生物标志物来筛查ICIs治疗优势人群仍是一大热点。方法收集51例晚期恶性肿瘤患者的肿瘤组织和配对血样本,进行PD-L1表达的相关性分析。40例晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者接受ICIs治疗,2个月时检测血液PD-L1(bloodPD-L1,bPD-L1)表达的动态变化,包括PD-L1 mRNA、外泌体PD-L1(exosomalPD-L1,exoPD-L1)蛋白和可溶性PD-L1(solublePD-L1,sPD-L1)。应用R软件计算最佳截断值,用于预测最佳客观缓解(best objective response,b OR)、无进展生存期(progression-free survival,PFS)和总生存期(overall survival,OS)。结果51例不同恶性肿瘤患者中,组织PD-L1(tissuePD-L1,tPD-L1)表达阳性患者的PD-L1mRNA表达水平显著升高。40例接受ICIs治疗的晚期NSCLC患者中,bPD-L1 mRNA上调≥2.04的患者b OR、PFS和OS更佳;21例接受ICIs治疗的晚期NSCLC患者中,exoPD-L1上调≥1.86的患者临床获益更大。sPD-L1动态变化与ICIs疗效无显著相关性。PD-L1 mRNA和exoPD-L1联合检测更有利于预测ICIs治疗疗效。结论bPD-L1表达与tPD-L1表达存在正相关;晚期NSCLC患者ICIs治疗初期PD-L1 mRNA和(或)exoPD-L1表达升高,可作为评估临床获益的新型生物标志物。 | Qiao YANG Mingjing CHEN Jiaoyang GU Kai NIU Xianlan ZHAO Linpeng ZHENG Zihan XU Yongxin YU Feng LI Lingxin MENG Zhengtang CHEN Wenlei ZHUO Luping ZHANG Jianguo SUN 杨峤(译) 孙建国(译) | 2021 | 中国肺癌杂志2021，24，12： | 10 |
| 5 | A Review on Binderless Tungsten Carbide: Development and Application显示文摘WC-Co alloys have enjoyed great practical significance owing to their excellent properties during the past decades.Despite the advantages,however,recently there have been concerns about the challenges associated with the use of Co,i.e.price instability,toxicity and properties degeneration,which necessitates the fabrication of binderless tungsten carbide(BTC).On the other hand,BTC or BTC composites,none of them,to date has been commercialized and produced on an industrial scale,but only used to a limited extent for specialized applications,such as mechanical seals undergoing high burthen as well as high temperature electrical contacts.There are two challenges in developing BTC:fully densifying the sintered body together with achieving a high toughness.Thus,this review applies towards comprehensively summarize the current knowledge of sintering behavior,microstructure,and mechanical properties of BTC,highlighting the densification improving strategies as well as toughening methods,so as to provide reference for those who would like to enhance the performance of BTC with better reliability advancing them to further wide applications and prepare the material in a way that is environment friendly,harmless to human health and low in production cost.This paper shows that the fabrication of highly dense and high-performance BTC is economically and technically feasible.The properties of BTC can be tailored by judiciously selecting the chemical composition coupled with taking into careful account the effects of processing techniques and parameters. | Jialin Sun Jun Zhao Zhifu Huang Ke Yan Xuehui Shen Jiandong Xing Yimin Gao Yongxin Jian Hejie Yang Bo Li | 2020 | Nano-Micro Letters2020，12，1： | 8 |
| 6 | Simulation of spatially correlated earthquake ground motions for engineering purposes显示文摘A new model to simulate spatially correlated earthquake ground motions is developed. In the model, the main factors that characterize three distinct effects of spatial variability, namely, the incoherency effect, the wave-passage effect and the site-response effect, are taken into account, and corresponding terms/parameters are incorporated into the well known model of uniform ground motions. Some of these terms/parameters can be determined by the root operation, and others can be calculated directly. The proposed model is fi rst verif ied theoretically, and examples of ground motion simulations are provided as a further illustration. It is proven that the ensemble expected value and the ensemble auto-/cross-spectral density functions of the simulated ground motions are identical to the target spectral density functions. The proposed model can also be used to simulate other correlated stochastic processes, such as wave and wind loads. | Wu Yongxin Gao Yufeng Li Dayong | 2011 | Earthquake Engineering and Engineering Vibration2011，10，2： | 7 |
| 7 | Transition from Metastablity to Instability in Dynamics for the Precipitation of δ'(Al_3Li)显示文摘A computer simulation study on dynamics for the precipitation of δ’(Al3Li) ordered particles from a disor- dered matrix (α) in binary Al-Li alloys is performed using the microscopic Langevin equation. A unique precipitation mechanism is found near the ordering spinodal line. Different from the classical nucleation mechanism in the me- tastable region and the congruent ordering followed by spinodal decomposition in the instable region, a nonstoichi- ometric single ordered phase with composition fluctuations is formed by non-classical nucleation, and this ordered phase decomposes spinodally. It can be concluded that the precipitation dynamics of δ’ phase from metastability to instability is gradual, and no sharp transition occurs near the mean-field spinodal line as the mean-field theory pre- dicts. | Xiaoling Li, Zheng Chen, Bing Liu, Yongxin Wang Department of Materials Science and Engineering, Northwestern Polytechnical University. Xi’an, 710072, China | 2001 | Rare Metals2001，20，4： | 7 |
| 8 | The impact of endplate fracture on postoperative vertebral height loss and kyphotic deformity during treatment of osteoporotic vertebral compression fractures with balloon kyphoplasty显示文摘This retrospective study investigated the impact of endplate fracture on postoperative vertebral height loss and kyphotic deformity in 144 patients with osteoporotic vertebral compression fracture(OVCF),who received balloon kyphoplasty.Patients were divided into four groups:Group 1 had no superior endplate fracture,Group 2 had fractures on the anterior portion of the superior endplate,Group 3 had fractures on the posterior portion of the superior endplate,and Group 4 had complete superior endplate fractures.Anterior and middle vertebral body height,vertebral compression ratio,vertebral height loss rate,and kyphosis Cobb angle of each patient were measured and visual analogue scale(VAS) and Oswestry disability index(ODI) scores were recorded.The anterior vertebral height and kyphosis deformity of all groups significantly improved after the surgery,whereas substantial anterior vertebral height loss and increased Cobb angle were observed in all patients at the last follow-up.Although the vertebral height loss rate and the Cobb angle in Group 2,3 and 4 were larger compared with Group 1 at the last follow-up,only the vertebral height loss rate in Group 4 and the increase in the Cobb angle in Group 2 and 4 were statistically different from those in Group 1.The VAS and ODI scores in all groups measured after the surgery and at the last follow-up were significantly lower compared with preoperative scores,but there was no significant difference among these groups.Balloon kyphoplasty significantly improved vertebral fracture height and kyphosis.Vertebral height loss and increased kyphotic deformity were observed in OVCF patients with endplate fractures after the surgery.Postoperative aggravation of kyphosis was observed in Group 2.Furthermore,severe vertebral height loss and increased kyphotic deformity were confirmed in Group 4 after the surgery.Our results suggested that postoperative vertebral height loss and aggravation of kyphosis may be associated with biomechanical changes in the vertebral body caused by endplate fracture.Therefore,surgery should not only restore compressed vertebral body height and correct kyphosis,but also correct the deformity of endplate to achieve an effective treatment of OVCF patients with endplate fracture. | Qingqing Li Long Xiao Jianwei Zhang Jin Fan Wei Zhou Guoyong Yin Yongxin Ren | 2016 | The Journal of Biomedical Research2016，30，5： | 5 |
| 9 | A cell-based high-throughput approach to identify inhibitors of influenza A virus显示文摘Influenza is one of the most common infections threatening public health worldwide and is caused by the influenza virus.Rapid emergence of drug resistance has led to an urgent need to develop new anti-influenza inhibitors.In this study we established a 293T cell line that constitutively synthesizes a virus-based negative strand RNA,which expresses Gaussia luciferase upon influenza A virus infection.Using this cell line,an assay was developed and optimized to search for inhibitors of influenza virus replication.Biochemical studies and statistical analyses presented herein demonstrate the sensitivity and reproducibility of the assay in a high-throughput format(Z 0 factor value40.8).A pilot screening provides further evidence for validation of the assay.Taken together,this work provides a simple,convenient,and reliable HTS assay to identify compounds with anti-influenza activity. | Qian Gao Zhen Wang Zhenlong Liu Xiaoyu Li Yongxin Zhang Zhizhen Zhang Shan Cen | 2014 | Acta Pharmaceutica Sinica B2014，4，4： | 5 |
| 10 | Primary Screening of 10-Hydroxy-2-Decenoic Acid Productive Strains显示文摘In this paper, eleven strains, which were screened strictly from raw royal jelly, soil andhoneycomb etc. by meansof dilution plate and spread plate methods, were cultured at 28℃ for 60 h with shaking. To determine whether they could yield10-Hydroxy-2-decenoic acid during fermentation, gas chromatography and gas chromatography-mass spectrometry methodswere used. The results showed that the strains BH002 and BH004, were both identified as Crytococcaceae, where BH002was primarily classified into Candida for possessing the abilities. The 10-HDA productivity of Candida BH002 and that ofBH004 were 0.327% and 0.2648% respectively. | Bailin Li Yongxin Kang Lingjing Wei Lizhen HuangFaculty of Food Science & Technology Shanghai Fisheries University Shanghai 200090 | 2002 | 食品科学2002，23，8： | 4 |
| 11 | A novel requirement analysis approach for periodic control systems显示文摘 | Zheng WANG Geguang PU Jiangwen LI Yuxiang CHEN Yongxin ZHAO Mingsong CHEN Bin GU Mengfei YANG Jifeng HE | 2013 | Frontiers of Computer Science2013，7，2： | 3 |
| 12 | The molecular determinants governing the immunogenicity of Japanese encephalitis live attenuated vaccines显示文摘In the course of isolating the attenuated Japanese encephalitis vaccine SA14-14-2,two attenuated strains SA14-9-7 and SA14-5-3 were also obtained that elicited low antibody responses in humans(o10%and 62%,respectively)and exerted much weaker immune protection in animal challenge experiments.However,the reason for these differences remains unknown.In order to understand why SA14-14-2 is superior to SA14-9-7 and SA14-5-3,we employed a reverse genetics method to identify the key mutations in the virus genome that determine the immunogenicity of live attenuated Japanese encephalitis viruses.We first sequenced the full genomic sequences of SA14-9-7 and SA14-5-3 and found mutations that changed four amino-acid base pairs when compared to the envelope gene of SA14-14-2.We mutated the genome of SA14-14-2 to generate these mutations both singly(E-177,E-264,E-279 and E-315)and in combination(E-177/264,E-279/315 and E-177/264/279/315)and tested these mutants along with parental strains SA14-14-2,SA14-9-7 and SA14-5-3 for their immunogenicity in vivo.When mice were immunized with SA14-9-7 and SA14-5-3,lower levels of neutralizing antibodies were generated compared with the immune response to SA14-14-2.Furthermore,SA14-5-3 was more immunogenic than SA14-9-7,which replicated the results previously seen in humans.Point mutations E-177,E-264,E-279 and E-315 diminished the immunogenicity of SA14-14-2 with E-264 and E-315,contributing the most to this phenotype.The mutant rJEV(E-177/E-264/E-279/E-315)containing all four point mutations exhibited the lowest immunogenicity with a seroconversion rate of 0 at an inoculation dose of 103 PFU(plaque-forming unit).We have identified the key amino acids in the envelope protein that account for the superior immunogenicity of SA14-14-2. | Yuhua Li Yin Fu Xinyu Liu Huiqiang Yang Yongxin Yu Lili Jia Xuguang Li Aaron Farnsworth Junzhi Wang | 2017 | Signal Transduction and Targeted Therapy2017，2，1： | 3 |
| 13 | Measurement and Result of Soil Gas Radon and Soil Gas Mercury in the Exploration of Haihe Hidden Fault显示文摘In the exploration of the hidden Haihe fault,radon and mercury in soil gas were measured by using FG-3017 radon detector and XG-4 mercury analyzer.In this paper,based on the measurement results of 12 fault gas profiles,and integrating with the exploration results of artificial seismic prospecting,the relationship between anomalous site of fault gas and fault location is analyzed.Using the relationship between anomalous strength of fault gas and fault activity,the activity of Haihe fault is studied,thus the location and activity segmentation of the Haihe fault in Tianjin region are presented.This study shows that the method of fault gas detection can not only identify the preliminary location of fault,but also make preliminary segmentation of fault activity.The fault detected by the method of fault gas measurement is shown as a band.Through contrasting with exploration results of artificial seismic prospecting and analyzing,we find that the fault is located inside the band.According to the measurements of soil gas radon,the Haihe fault can be divided into east and west segments and the activity of the east segment of Haihe fault is stronger than that of the west segment.This is only a relative result,and it is difficult to judge whether the fault is active or not with this result. | Shao Yongxin Yang Xulian Li Yibing | 2008 | Earthquake Research in China2008，22，2： | 3 |
| 14 | Effect of anterior tympanomeatal angle blunting on the middle ear transfer function using a finite element ear model显示文摘 | Jie Wang Fei Zhao Yongxin Li Demin Han Shusheng Gong Shouqin Zhao Hua Zhang | 2011 | Medical Engineering and Physics2011，，9： | 3 |
| 15 | A comparative study of magnetic properties between whole cells and isolated magnetosomes of Magnetospirillum magneticum AMB-1显示文摘The magnetic properties of magnetosome magnetite are of interdisciplinary interest because magnetosomes are potential carriers of natural remanent magnetization and paleoenvironment, as well as novel nano-biomaterials in biotechnological and biomedical applications. We carried out magnetic and electron transmission microscopy analyses of fresh Magnetospirillum magneticum AMB-1 whole cells and isolated magnetosomes. Results revealed that AMB-1 synthesized single-domain magnetite magneto-somes, which are arranged in the form of linear fragmental chain. The distinct differences of magnetic properties between these two samples can be faithfully interpreted in terms of spatial arrangement of magnetosomes and magnetostatic interaction. For the whole cells, the strong intra-chain interactions and weak inter-chain interactions generate behaviors of non-interacting uniaxial single-domain particles. Its δ-ratio is 3.0 and passes the Moskowitz test. In contrast, the isolated magnetosome sample has reduced values of coercivity and δ-ratio (1.5), due to increasing three-dimensional magnetostatic interactions and collapse of magneto-some chains. These observations provide useful insights into applications of the biogenic magnetite (magnetosomes) in magnetic nano-materials and magnetofossils in the paleomagnetic and environmental magnetism. | LI JinHua PAN YongXin LIU QingSong QIN HuaFeng DENG ChengLong CHE RenChao YANG XinAn | 2010 | Chinese Science Bulletin2010，55，1： | 3 |
| 16 | Effect of acupuncture plus conventional treatment on brain activity in ischemic stroke patients: a regional homogeneity analysis显示文摘OBJECTIVE: To determine differences in cerebral activity evoked by acupuncture and conventional stroke treatment, and identify the treatment targets.METHODS: In total, 21 patients were randomly divided into two groups. Group A(11 patients) received both acupuncture and conventional treatment, while group B(10 patients) received conventional treatment only. Resting-state functional magnetic resonance imaging(f MRI) was performed on each participant before and after treatment. Regional homogeneity analysis was performed to investigate the potential mechanism of acupuncture treatment by comparing differences in cerebral activity between treatments.RESULTS: Group A showed higher Re Ho in the frontal lobe(BA6, BA46), supra-marginal gyrus(BA40),middle temporal gyrus(BA21), cerebellum, and insula. Group B showed higher Re Ho in the frontal lobe(BA6) and parietal lobe(BA3, BA7).CONCLUSION: Acupuncture and conventional treatment triggered relatively different clinical efficacy and brain responses. Acupuncture treatment more significantly improved the symptoms of stroke patients. More marked changes in sensory,emotional, and motor areas(including the frontal lobe, middle temporal gyrus, cerebellum, and insula) might reflect the specific acupuncture mechanism. | Wu Ping Zeng Fang Li Yongxin Li Ji Qiu Lihua Qin Wei Luo Lu Yin Canxin Xiong Yan Bai Yu Wang Dan Zhou Yumei Liang Fanrong | 2017 | Journal of Traditional Chinese Medicine2017，37，5： | 3 |
| 17 | Rett syndrome-causing mutations compromise MeCP2- mediated liquid—liquid phase separation of chromatin显示文摘Rett syndrome(RTT),a severe postnatal neurodevelopmental disorder,is caused by mutations in the X-linked gene encoding methyl-CpG-binding protein 2(MeCP2).MeCP2 is a chromatin organizer regulating gene expression.RTT-causing mutations have been shown to affect this function.However,the mechanism by which MeCP2 organizes chromatin is unclear.In this study,we found that MeCP2 can induce compaction and liquid-liquid phase separation of nudeosomal arrays in vitro,and DNA methylation further enhances formation of chromatin condensates by MeCP2.Interestingly,RTT-causing mutations compromise MeCP2-mediated chromatin phase separation,while benign variants have little effect on this process.Moreover,MeCP2 competes with linker histone H1 to form mutually exclusive chromatin condensates in vitro and distinct heterochromatin foci in vivo.RTT-causing mutations reduce or even abolish the ability of MeCP2 to compete with histone H1 and to form chromatin condensates.Together,our results identify a novel mechanism by which phase separation underlies MeCP2-mediated heterochromatin formation and reveal the potential link between this process and the pathology of RTT. | Liang Wang Mingli Hu Mei-Qing Zuo Jicheng Zhao Di Wu Li Huang Yongxin Wen Yunfan Li Ping Chen Xinhua Bao Meng-Qiu Dong Guohong Li Pilong Li | 2020 | Cell Research2020，30，5： | 3 |
| 18 | Contrasting vegetation changes in dry and humid regions ofthe Tibetan Plateau over recent decades显示文摘An overall greening over the Tibetan Plateau(TP) in recent decades has been established through analyses of remotely sensed Normalized Difference Vegetation Index(NDVI), though the regional pattern of the changes and associated drivers remain to be explored. This study used a satellite Leaf Area Index(LAI) dataset(the GLASS LAI dataset) and examined vegetation changes in humid and arid regions of the TP during 1982–2012. Based on distributions of the major vegetation types, the TP was divided roughly into a humid southeastern region dominated by meadow and a dry northwestern region covered mainly by steppe. It was found that the dividing line between the two regions corresponded well with the lines of mean annual precipitation of 400 mm and the mean LAI of 0.3. LAI=0.3 was subsequently used as a threshold for investigating vegetation type changes at the interanual and decadal time scales: if LAI increased from less than 0.3 to greater than0.3 from one time period to the next, it was regarded as a change from steppe to meadow, and vice versa. The analysis shows that changes in vegetation types occurred primarily around the dividing line of the two regions, with clear growth(reduction) of the area covered by meadow(steppe), in consistency with the findings from using another independent satellite product. Surface air temperature and precipitation(diurnal temperature range) appeared to contribute positively(negatively) to this change though climate variables displayed varying correlation with LAI for different time periods and different regions. | RuiQing Li YanHong Gao DeLiang Chen YongXin Zhang SuoSuo Li | 2018 | Research in Cold and Arid Regions2018，10，6： | 3 |
| 19 | Phases equilibrated with long-period stacking ordered phases in the Mg-rich corner of the Mg-Y-Zn system显示文摘Phase equilibria involving the long-period stacking ordered phases including 14 H,18 R and 10 H in the Mg-rich corner of the Mg-Y-Zn system at 400 and 500℃ have been experimentally investigated by using X-ray diffraction(XRD),scanning electron microscopy(SEM),transmission electron microscopy(TEM)and high-angle annular dark-field scanning transmission electron microscopy(HAADF-STEM).The coexistence of 14 H and 18 R as well as 18 R and 10 H was confirmed from atomic scales.The phases 14 H,18 R and 10 H were all stable phases from 400 to 500℃.The experimentally proved three-phase equilibrium of14 H,18 R and α-Mg instead of 14 H,18 R and Mg_(24)Y_(5) were presented in the modified isothermal sections.The latter three-phase equilibrium was reported in the available literature.The modified isothe rmal sections are conducive to guide the composition design to obtain the alloys with favorable microstructure constituents and mechanical properties. | Yongxin Ruan Changrong Li Yuping Ren Xiaopan Wu Schmid-Fetzer Cuiping Guo Zhenmin Du | 2021 | Journal of Materials Science & Technology2021，，9： | 3 |
| 20 | Dopaminergic Neurons in the Ventral Tegmental–Prelimbic Pathway Promote the Emergence of Rats from Sevoflurane Anesthesia显示文摘Dopaminergic neurons in the ventral tegmental area(VTA)play an important role in cognition,emergence from anesthesia,reward,and aversion,and their projection to the cortex is a crucial part of the'bottom-up'ascending activating system.The prelimbic cortex(PrL)is one of the important projection regions of the VTA.However,the roles of dopaminergic neurons in the VTA and the VTADA–PrL pathway under sevoflurane anesthesia in rats remain unclear.In this study,we found that intraperitoneal injection and local microinjection of a dopamine D1 receptor agonist(Chloro-APB)into the PrL had an emergence-promoting effect on sevoflurane anesthesia in rats,while injection of a dopamine D1 receptor antagonist(SCH23390)deepened anesthesia.The results of chemogenetics combined with microinjection and optogenetics showed that activating the VTADA–PrL pathway prolonged the induction time and shortened the emergence time of anesthesia.These results demonstrate that the dopaminergic system in the VTA has an emergence-promoting effect and that the bottom-up VTADA–PrL pathway facilitates emergence from sevoflurane anesthesia. | Yanping Song Ruitong Chu Fuyang Cao Yanfeng Wang Yanhong Liu Jiangbei Cao Yongxin Guo Weidong Mi Li Tong | 2022 | Neuroscience Bulletin2022，38，4： | 3 |
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