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| 1 | Stable classi?cation with limited sample: transferring a 30-m resolution sample set collected in 2015 to mapping 10-m resolution global land cover in 2017显示文摘As the world strives to reduce the impact of population growth, urbanization, agricultural expansion, and climate change on food security, energy and water shortage, resource over-exploration, biodiversity loss, environmental pollution, and ultimately human health, timely and higher resolution land cover information is urgently needed to achieve the sustainable development goals of the United Nations. | Peng Gong Han Liu Meinan Zhang Congcong Li Jie Wang Huabing Huang Nicholas Clinton Luyan Ji Wenyu Li Yuqi Bai Bin Chen Bing Xu Zhiliang Zhu Cui Yuan Hoi Ping Suen Jing Guo Nan Xu Weijia Li Yuanyuan Zhao Jun Yang Chaoqing Yu Xi Wang Haohuan Fu Le Yu Iryna Dronova Fengming Hui Xiao Cheng Xueli Shi Fengjin Xiao Qiufeng Liu Lianchun Song | 2019 | Science Bulletin2019，64，6： | 166 |
| 2 | Tectonic thermal history and its significance on the formation of oil and gas accumulation and mineral deposit in Ordos Basin显示文摘The analyzing data on stratigraphic temperature measurement , thermal conductivity of the strata and radioactive heat production rate show that the present average geothermal gradient in the Ordos Basin is 2.93℃/100 m, and the average heat flow value is 61.78 mW/m2, which belongs to the mesothermal basin, and the value of the present geothermal gradient and heat flow in the east is higher than that in the west. The sandstone radioactive heat production rate of Zhiluo Group in Dongsheng Uranium deposits of Yimeng uplift is obviously higher in the mudstone, indicating that there exists a uranium anomaly. Based on studies of the present thermal field of the basin, the late-Mesozoic paleotemperature and paleogeothermal gradient are determined by using different kinds of paleotemperature methods. According to the anomaly of the late-Mesozoic paleotemperature gradient and magmatic event age, there was a tectonic thermal event in the early Cretaceous epoch of late-Mesozoic. This article rebuilds tectonic thermal history of different tectonic units by thermal history simulation using basin simulating software. The evolution of oil-gas and coal, and accumulation (mineralization) of mineral uranium are all controlled by the tectonic thermal history in the Ordos basin, especially by the tectonic thermal event that happened in the late Mesozoic. For both the gas source rocks of upper Paleozoic group and lower paleozoic group, the gas was largely generated in the early Cretaceous epoch of the late Mesozoic. The main petroleum generation period for Yanchang Group in Triassic system is the early Cretaceous epoch too, and the highest thermal maturity of the coal of Permo-Carboniferous, Triassic, and Jurassic reaches is the early Cretaceous epoch also. Early Cretaceous epoch is still one of the most important mineralizing periods of uranium. | REN ZhanLi ZHANG Sheng GAO ShengLi CUI JunPing XIAO YuanYuan XIAO Hui | 2007 | Science China Earth Sciences2007，50，z2： | 44 |
| 3 | Community structure and elevational diversity patterns of soil Acidobacteria显示文摘Acidobacteria is one of the most dominant and abundant phyla in soil,and was believed to have a wide range of metabolic and genetic functions. Relatively little is known about its community structure and elevational diversity patterns. We selected four elevation gradients from 1000 to 2800 m with typical vegetation types of the northern slope of Shennongjia Mountain in central China. The vegetation types were evergreen broadleaved forest,deciduous broadleaved forest,coniferous forest and sub-alpine shrubs. We analyzed the soil acidobacterial community composition,elevational patterns and the relationship between Acidobacteria subdivisions and soil enzyme activities by using the 16 S rRNA meta-sequencing technique and multivariate statistical analysis. The result found that 19 known subdivisions as well as an unclassified phylotype were presented in these forest sites,and Subdivision 6 has the highest number of detectable operational taxonomic units(OTUs). A significant single peak distribution pattern(P < 0.05) between the OTU number and the elevation was observed. The Jaccard and Bray–Curtis index analysis showed that the soil Acidobacteria compositional similarity significantly decreased(P < 0.01) with the increase in elevation distance. Mantel test analysis showed the most of the soil Acidobacteria subdivisions had the significant relationship(P < 0.01) with different soil enzymes. Therefore,soil Acidobacteria may be involved in different ecosystem functions in global elemental cycles. Partial Mantel tests and CCA analysis showed that soil pH,soil temperature and plant diversity may be the key factors in shaping the soil Acidobacterial community structure. | Yuguang Zhang Jing Cong Hui Lu Guangliang Li Yuanyuan Qu Xiujiang Su Jizhong Zhou Diqiang Li | 2014 | Journal of Environmental Sciences2014，26，8： | 17 |
| 4 | A two-step lineage reprogramming strategy to generate functionally competent human hepatocytes from fibroblasts显示文摘Terminally differentiated cells can be generated by lineage reprogramming,which is,however,hindered by incomplete conversion with residual initial cell identity and partial functionality. Here, we demonstrate a new reprogramming strategy by mimicking the natural regeneration route, which permits generating expandable hepatic progenitor cells and functionally competent human hepatocytes. Fibroblasts were first induced into human hepatic progenitor-like cells (hHPLCs), which could robustly expand in vitro and efficiently engraft in vivo. Moreover, hHPLCs could be efficiently induced into mature human hepatocytes (hiHeps) in vitro, whose molecular identity highly resembles primary human hepatocytes (PHHs). Most importantly, hiHeps could be generated in large quantity and were functionally competent to replace PHHs for drug-metabolism estimation, toxicity prediction and hepatitis B virus infection modeling. Our results highlight the advantages of the progenitor stage for successful lineage reprogramming. This strategy is promising for generating other mature human cell types by lineage reprogramming. | Bingqing Xie Da Sun Yuanyuan Du Jun Jia Shicheng Sun Jun Xu Yifang Liu Chengang Xiang Sitong Chen Huangfan Xie Qiming Wang Guangya Li Xuehui LYU Hui Shen Shiyu Li Min Wu Xiaonan Zhang Yue Pu Kuanhui Xiang Weifeng Lai Peng Du Zhenghong Yuan Cheng Li Yan Shi Shichun Lu Hongkui Deng | 2019 | Cell Research2019，29，9： | 9 |
| 5 | Precipitates and alloying elements distribution in nearαtitanium alloy Ti65显示文摘Precipitates,including silicides and Ti3 Al(α2)phase,and alloying elements distribution in a near a titanium alloy Ti65(Ti-5.8 Al-4.0 Sn-3.5 Zr-0.5 Mo-0.3 Nb-1.0 Ta-0.4 Si-0.8 W-0.05 C)after solution treatment and aging process were characterized by using transmission electron microscopy(TEM)and atom probe tomography(APT).Quantitative composition analysis and TEM observation indicate that the silicides fit to(Ti,Zr)6(Sl,Sn)3.Zr exhibits aβ-stabilizing effect in near a titanium alloys but is weaker than otherβstabilizing elements.The enriching tendency of the alloying elements in the retainedβphase is in the order of Zr | Ke Yue Jianrong Liu Haijun Zhang Hui Yu Yuanyuan Song Qingmiao Hu Qingjiang Wang Rui Yang | 2020 | Journal of Materials Science & Technology2020，36，1： | 8 |
| 6 | Gapless indica rice genome reveals synergistic contributions of active transposable elements and segmental duplications to rice genome evolution显示文摘The ultimate goal of genome assembly is a high-accuracy gapless genome.Here,we report a new assembly pipeline that is used to produce a gapless genome for the indica rice cultivar Minghui 63.The resulting 397.71-Mb final assembly is composed of 12 contigs with a contig N50 size of 31.93 Mb.Each chromosome is represented by a single contig and the genomic sequences of all chromosomes are gapless.Quality evaluation of this gapless genome assembly showed that gene regions in our assembly have the highest completeness compared with the other 15 reported high-quality rice genomes.Further comparison with the japonica rice genome revealed that the gapless indica genome assembly contains more transposable elements(TEs)and segmental duplications(SDs),the latter of which produce many duplicated genes that can affect agronomic traits through dose effect or sub-/neo-functionalization.The insertion of TEs can also affect the expression of duplicated genes,which may drive the evolution of these genes.Furthermore,we found the expansion of nucleotide-binding site with leucine-rich repeat disease-resistance genes and cis-zeatin-O-glucosyltransferase growth-related genes in SDs in the gapless indica genome assembly,suggesting that SDs contribute to the adaptive evolution of rice disease resistance and developmental processes.Collectively,our findings suggest that active TEs and SDs synergistically contribute to rice genome evolution. | Kui Li Wenkai Jiang Yuanyuan Hui Mengjuan Kong Li-Ying Feng Li-Zhi Gao Pengfu Li Shan Lu | 2021 | Molecular Plant2021，14，10： | 6 |
| 7 | Mechanism Analysis of Stiffness Improvement by Waterborne Epoxy Resin Surface Sizing Agent显示文摘Low-basis-weight paper lacks normal strength and stiffness. Waterborne epoxy resin could be employed with oxidized starch to improve paper stiffness through surface sizing. In this study,the mechanism of enhancing stiffness by adding waterborne epoxy resin was fully investigated. The results indicated that through surface sizing with epoxy resin,the paper thickness was preserved,whereas the elastic modulus increased significantly and the epoxy resin had positive impact on single fiber strength. A rigid resin layer and interpenetrating polymer network formed on the surface and in the inner layer of the paper,respectively. The formed resin layer and interpenetrating polymer network strongly supported the paper,leading to the improvement of the elastic modulus and stiffness. The stiffness improvement through surface sizing was mainly due to the formation of a fibrous composite layer and penetration of the sizing agent into the inner layers of the paper. The better the combination between fiber and sizing agent,the higher were the elastic modulus and the stiffness of the whole paper. | Hui Xu ShuMei Wang YuanYuan Li HongQi Dai | 2016 | Paper And Biomaterials2016，1，1： | 4 |
| 8 | Argininosuccinate synthase 1 suppresses cancer cell invasion by inhibiting STAT3 pathway in hepatocellular carcinoma显示文摘Metastasis is the main reason for high recurrence and poor survival of hepatocellular carcinoma(HCC).The molecular mechanism underlying HCC metastasis remains unclear.In this study,we found that argininosuccinate synthase 1(ASS1)expression was significantly decreased and down-regulation of ASS1 was closely correlated with poor prognosis in HCC patients.DNA methylation led to the down-regulation of ASS1 in HCC.Stable silencing of ASS1 promoted migration and invasion of HCC cells,whereas overexpression of ASS1-inhibited metastasis of HCC cells in vivo and in vitro.We also revealed that ASS1-knockdown increased the phosphorylation level of S727STAT3,which contributed to HCC metastasis by up-regulation of inhibitor of differentiation 1(ID1).These findings indicate that ASS1 inhibits HCC metastasis and may serve as a target for HCC diagnosis and treatment. | Xuemei Tao Qiaozhu Zuo Haoyu Ruan Hui Wang Haojie Jin Zhuoan Cheng Yuanyuan Lv Wenxin Qin Cun Wang | 2019 | Acta Biochimica et Biophysica Sinica2019，51，3： | 4 |
| 9 | First experimental constraints on WIMP couplings in the effective field theory framework from CDEX显示文摘We present weakly interacting massive particles(WIMPs) search results performed using two approaches of effective field theory from the China Dark Matter Experiment(CDEX), based on the data from both CDEX-1B and CDEX-10 stages. In the nonrelativistic effective field theory approach, both time-integrated and annual modulation analyses were used to set new limits for the coupling of WIMP-nucleon effective operators at 90% confidence level(C.L.) and improve over the current bounds in the low mχregion. In the chiral effective field theory approach, data from CDEX-10 were used to set an upper limit on WIMP-pion coupling at 90% C.L. We for the first time extended the limit to the m_(χ)<6 GeV/c^(2) region. | Yi Wang Zhi Zeng Qian Yue LiTao Yang KeJun Kang YuanJing Li Mehment Agartioglu HaiPeng An JianPing Chang JingHan Chen YunHua Chen JianPing Cheng Cheng Yi Chiang WenHan Dai Zhi Deng ChangHao Fang XinPing Geng Hui Gong QiuJu Guo XuYuan Guo HongJian He Li He ShengMing He JinWei Hu TuChen Huang HanXiong Huang HaiTao Jia LiPing Jia Xi Jiang HauBin Li JianMin Li Jin Li MingXuan Li RenMingJie Li Xia Li YuLan Li Bin Liao FongKay Lin ShinTed Lin ShuKui Liu YanDong Liu Yu Liu YuanYuan Liu ZhongZhi Liu Hao Ma YuCai Mao QiYuan Nie JinHua Ning Hui Pan NingChun Qi Jie Ren XiChao Ruan ChangSong Shang Vivek Sharma Ze She Lakhwinder Singh Monoj Kumar Singh TianXi Sun ChangJian Tang WeiYou Tang Yang Tian GuangFu Wang Li Wang Qing Wang Yu Chen Wang YunXiang Wang Zhen Wang Henry Tsz-King Wong ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue YuLu Yan Nan Yi ChunXu Yu HaiJun Yu JianFeng Yue Ming Zeng BingTao Zhang Lei Zhang FengShou Zhang ZhenYu Zhang KangKang Zhao MingGang Zhao JiFang Zhou ZuYing Zhou JingJun Zhu | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，8： | 3 |
| 10 | Tagging single nucleotide polymorphisms in the PPAR-γ and RXR-α gene and type 2 diabetes risk:a case-control study of a Chinese Han population显示文摘Peroxisome proliferator-activated receptor (PPAR-γ),which is mainly involved in adipocyte differentiation, has been suggested to play an important role in the pathogenesis of insulin resistance and atherosclerosis. We investigated the frequencies of two common tagging polymorphisms of the PPAR-γ gene and two of PPAR-α with minor allele frequency (MAF)≥ 0.05 in the Chinese Han population and analyzed the correlation between the different genotypes and the risk of type 2 diabetes mellitus (T2DM). TaqMan assay was performed to test the genotypes in T2DM patients (n = 1,105) and normal controls (n = 1,107). Serum adiponectin concentration was measured by ELISA kit. The variant genotypes rs17817276GG, rs3856806CT and rs3856806CT/TT of PPAR-γ were associated with T2DM, P = 0.023,0.037 and 0.018, respectively. Furthermore, the prevalence of haplotype GT in PPAR-γ was less frequent in the case subjects (0.3%) than in the controls (1.9%) [P < 0.001,OR(95%CI)=0.13 (0.06-0.31)]. Patients with genotype TT of rs3856806 had a higher serum level of adiponectin than those with the genotype CC and CT (P = 0.031 and 0.038, respectively). There was no statistically significant difference between patients and controls in genotype distribution of rs6537944 and rs1045570 of the RXR-α gene. The present study suggests that the variant genotypes in the PPAR-γ gene could decrease the risk for the development of T2DM in the Chinese Han population. | Juan Du Hui Shi Ying Lu Wencong Du Yuanyuan Cao Qian Li Jianhua Ma Xinhua Ye Jinluo Cheng Xiaofang Yu Yanqin Gao Ling Zhou | 2011 | The Journal of Biomedical Research2011，25，1： | 3 |
| 11 | Surface-modified Zn_(0.5)Ti_(0.5)NbO_(4) particles filled polytetrafluoroethylene composite with extremely low dielectric loss and stable temperature dependence显示文摘Polymer-ceramic composites are widely applied in microwave substrate materials due to the excellent dielectric properties and simple preparation process recently.Polytetrafluoroethylene-based(PTFE)composites filled with Zn_(0.5)Ti_(0.5)NbO_(4)(ZTN)ceramic particles were fabricated by hot-pressing.The particles were modified by C_(14)H_(19)F_(13)O_(3)Si to enhance the interface compatibility between PTFE and ZTN powders,which was characterized by X-ray photoelectron spectroscopy(XPS)and contact angle.The surface characteristic of particles transformed into hydrophobicity and tight microstructure as well as better dielectric properties were obtained after the surface modification.The microstructure,dielectric,thermal,mechanical properties,and water absorption of the composites concerning ZTN content were investigated.Modified ZTN/PTFE composites with 50 vol% ZTN particles exhibit excellent dielectric properties with a high dielectric constant of 8.3,an extremely low dielectric loss of 0.00055 at 7 GHz,and a stable temperature coefficient of the dielectric constant of-12.2 ppm/℃.All the properties show modified ZTN particles filled PTFE composite is the potential material for microwave substrate application. | Hao WANG Fuming ZHOU Jianming GUO Yuanyuan ZHANG Hui YANG Qilong ZHANG | 2020 | Journal of Advanced Ceramics2020，9，6： | 3 |
| 12 | Forest plant and macrofungal differences in the Greater and Lesser Khingan Mountains in Northeast China:A regional-historical comparison and its implications显示文摘Forests in Northeast China in the Greater and Lesser Khingan Mountains(GKM and LKM)account for nearly 1/3 of the total state-owned forests in the country.Regional and historical comparisons of forest plants and macrofungi will favor biological conservation,forest management and economic development.A total of 1067 sampling plots were surveyed on forest composition and structure,with a macrofungi survey at Liangshui and Huzhong Nature Reserves in the center of two regions.Regional and historical differences of these parameters were analyzed with a redundancy ordination of their complex associations.There were 61-76 families,189-196 genera,and 369-384 species,which was only 1/3 of the historical records.The same dominant species were larch and birch with Korean pine(a climax species)less as expected from past surveys in the LKM.Shrub and herb species were different in the two regions,as expected from historical records.There was 10-50%lower species diversity(except for herb evenness),but 1.8-to 4-time higher macrofungi diversity in the GKM.Compared with the LKM,both tree heights and macrofungi density were higher.Nevertheless,current heights averaging 10 m are half of historical records(>20 m in the 1960s).Edible macrofungi were the highest proportion in both regions,about twice that of other fungal groups,hav-ing important roles in the local economy.A major factor explaining plant diversity variations in both regions was herb cover,followed by shrubs in the GKM and herb-dominant species in the LKM.Factors responsible for macrofungi variations were tree density and shrub height.Vaccinium vitis-idaea and Larix gmelinii in the GKM but tree size and diversity were important factors in the LKM.Our findings highlighted large spatial and historical differences between the GKM and LKM in plant-macrofungal composition,forest structure,and their complex associations,which will favor precise conservation and management of forest resources in two region in the future. | Yuanyuan Wang Hui Wen Kai Wang Jingxue Sun Jinghua Yu Qinggui Wang Wenjie Wang | 2022 | Journal of Forestry Research2022，33，2： | 3 |
| 13 | Effects of tillage managements and maize straw returning on soil microbiome using 16S rDNA sequencing显示文摘Agricultural practices could affect bacterial diversity and community structure by altering soil physical and chemical properties. Straw returning and tillage practices are widely used in agriculture, however, the effects of these agricultural practices on microbiomes are still unclear. In the present study, we compared the 18 bacterial communities of soil with different straw returning and tillage treatment combinations. The V3-V4 regions of the 16S ribosomal RNA were amplified and analyzed by high-throughput sequencing technology. The results showed that the bacterial communities were consistently dominated by Acidobacteria, Proteobacteria, Actinobacteria, and Chloroflexi. Short-term straw returning and tillage practices significantly altered the diversity, relative abundance and functions of the soil microbiome. Soil subjected to rotary tillage and straw returning (RTS) combination possessed the highest bacterial diversity and lowest ratio of G+/G- bacteria, indicating that RTS could be an efficient integrated management system to improve microbiome in the short term. Double verifications based on relative abundance and network analysis, revealed close relationships of Mycobacterium and Methylibium with RTS, indicating they could serve as biomarkers for RTS. Investigating microbial changes under different agricultural practices will provide valuable foundations for land sustainable utilization and increase crop yields. | Xinyao Xia Piaopiao Zhang Linlin He Xingxing Gao Weijun Li Yuanyuan Zhou Zongxin Li Hui Li Long Yang | 2019 | Journal of Integrative Plant Biology2019，61，6： | 3 |
| 14 | Changes in Soil Enzyme Activity and Nutrient Content in Different Years of Continuous Cropping Tobacco Fields显示文摘In order to find out changes in the main fertility indicators of continuous cropping tobacco fields in Henan Province with years of continuous cropping,5 typical tobacco fields( Jia County,Shaoling District,Fangcheng County,Xiangcheng County,and Song County) were studied. Indicators in question included activity of main enzymes( sucrase,urease,catalase,and acid phosphatase),p H value,organic matters,total nitrogen,available phosphorus and available potassium. The results indicate that in most tobacco fields,the activity of sucrase and urease increased in two years of continuous cropping,later,it showed a declining trend with increase in years of continuous cropping; in some fields,it directly declined with increase in years of continuous cropping; the activity of catalase increased in two years of continuous cropping,later,it showed a declining trend with increase in years of continuous cropping,and it became stable after three years of continuous cropping;generally,the activity of acid phosphatase declined with increase in the years of continuous cropping within 3 years continuous cropping,later,it became stable. Except Fangcheng County,the soil p H value of other districts( counties) generally declined with increase in years of continuous cropping,and it was in the range of 5. 6-6. 8. With the increase in continuous cropping,the soil organic matters( SOM) in tobacco fields of Jia County and Song County declined,changes of SOM in tobacco fields of Fangcheng County and Xiangcheng County were not obvious,and SOM showed the trend of first decline then rise in Shaoling District. In most tobacco fields( Jia County,Xiangcheng County,and Song County),the total nitrogen showed a declining trend; in Shaoling District,it showed a trend of first decline then rise; in Fangcheng County,it showed a rising trend. The available phosphorus firstly slightly declined then rose in tobacco fields of Shaoling District and Song County; it showed a trend of first rise then decline in Jia County; there were no obvious changes in Fangcheng County and Xiangcheng County. Changes in the available potassium were different in tobacco fields. In sum,there are certain rules for changes in soil enzyme activity and nutrient content in tobacco fields in Henan Province,but changes are not completely the same. It is concluded that the site conditions and farming activities exert a certain influence on soil enzyme activity,p H value,organic matters,and nitrogen,phosphorus and potassium content. Therefore,to solve obstacles in continuous cropping of tobacco fields,different regions should take different measures. | Jifeng CHEN Hui SUN Yang XIA Kaixuan CAI Hongyuan LIU Yuanyuan LI Ruiliang GUO Bei HOU Shuai FENG Xiaoxin JIANG | 2017 | Asian Agricultural Research2017，9，5： | 2 |
| 15 | Algorithms for network-based identification of differential regulators from transcriptome data: a systematic evaluation显示文摘Identification of differential regulators is critical to understand the dynamics of cellular systems and molecular mechanisms of diseases.Several computational algorithms have recently been developed for this purpose by using transcriptome and network data.However,it remains largely unclear which algorithm performs better under a specific condition.Such knowledge is important for both appropriate application and future enhancement of these algorithms.Here,we systematically evaluated seven main algorithms(TED,TDD,TFactS,RIF1,RIF2,dCSA_t2t,and dCSA_r2t),using both simulated and real datasets.In our simulation evaluation,we artificially inactivated either a single regulator or multiple regulators and examined how well each algorithm detected known gold standard regulators.We found that all these algorithms could effectively discern signals arising from regulatory network differences,indicating the validity of our simulation schema.Among the seven tested algorithms,TED and TFactS were placed first and second when both discrimination accuracy and robustness against data variation were considered.When applied to two independent lung cancer datasets,both TED and TFactS replicated a substantial fraction of their respective differential regulators.Since TED and TFactS rely on two distinct features of transcriptome data,namely differential co-expression and differential expression,both may be applied as mutual references during practical application. | YU Hui MITRA Ramkrishna YANG Jing LI YuanYuan ZHAO ZhongMing | 2014 | Science China(Life Sciences)2014，57，11： | 2 |
| 16 | Smad5 acts as an intracellular pH messenger and maintains bioenergetic homeostasis显示文摘环境暗示和细胞内部的 bioenergetic 状态深刻地影响细胞内部的 pH (pHi ) 。一个房间怎么对 pHi 变化作出回应维持 bioenergetic 动态平衡,留下逃犯。这里,我们显示出那 Smad5,发信号的形态基因的蛋白质(BMP ) 回答到 pHi 的骨头的一个描绘得好的下游的部件变化。冷、基本或张力亢进的条件增加 pHi,它接着在 Smad5 的 MH1 域以内声言不赞成控告的氨基酸簇,推动它到细胞质的从原子核的重定位。在另一方面,加热,酸或张力减退的条件减少 pHi,堵住 Smad5 的原子出口,并且因此引起它的原子累积。环境变化和 pHi 变化导致的 Smad5 的活跃 nucleocytoplasmic shuttling 独立于 BMP 发信号, carboxyl 终点 phosphorylation 和 Smad4。另外, Smad5 的脱离引起在区别识别了的神经发展过程人的 pluripotent 干细胞建模的细胞的 bioenergetic 动态平衡和破坏正常的长期、不可逆的 dysregulation。重要地,在 Smad5 缺乏的房间的这些新陈代谢、发展的赤字能仅仅由细胞质的 Smad5 被救。细胞质的 Smad5 身体上与 hexokinase 交往 1 并且加速 glycolysis。一起,我们的调查结果显示 Smad5 充当一个 pHi 送信人并且由调整细胞质的新陈代谢的机械维持房间的 bioenergetic 动态平衡。 | Yujiang Fang Zhongliang Liu Zhenyu Chen Xiangjie Xu Mengtao Xiao Yanyan Yu Yuanyuan Zhang Xiaobai Zhang Yanhua Du Cizhong Jiang Yuzheng Zhao Yiran Wang Beibei Fan Daniel Terheyden-Keighley Yang Liu Lei Shi Yi Hui Xin Zhang Bowen Zhang Hexi Feng Lin Ma Quanbin Zhang Guohua Jin Yi Yang Bin Xiang Ling Liu Xiaoqing Zhang | 2017 | Cell Research2017，27，9： | 2 |
| 17 | A core-shell composite pigment with rutile TiO_(2) intensification for UV inhibition显示文摘Organic pigments generlly have bright colors but poor ultraviolet(UV)resistance.To improve the UV for UVinhibition is proposed by afacile sol-gel method inthis work.Acore-shellstructure,witha homo resistance and extend the applications,a core-shell composite pigment with rutile Tio intensification geneous sol-gel TiO_(2) shell containing additional nanosized rutile TiO2 particles and with the pigment as the core,was established taking advantage of UV resistance of TiO2 and binding ability of sol-gel.While the sol-gel TiO2 shell alone has already shown obvious ultraviolet shielding effect,as tested over different sol-gel aging times and Tio2 loadings,the UV resistance of the fluorescent pigments was further enhanced by binding the nanosized rutile TiO2 in the sol-gel shell At a sol-gel TiO2 to rutile TiO2 ratio of 2:1,the UV exposure time is extended about eight times compared with that of the original pigment and twice as that of the modifed pigment with pure sol-gel TiO2 for the same color change.Therefore,the novel core-shell composite pigment intensified with nanosized rutile Tio2 particles is proved to be effcient in improving the uV resistance of organic pigments. | Xiao Lv Baowei Yan Yuanyuan Shao Haiping Zhang Hui Zhang Jesse Zhu | 2022 | Particuology2022，20，8： | 2 |
| 18 | Performance evaluation of deep learning-based post-processing and diagnostic reporting system for coronary CT angiography: a clinical comparative study显示文摘To the Editor:Coronary computed tomography angiography(CCTA)has been increasingly,widely performed for diagnosing coronary artery,disease,lAnatomical diagnosis,that is,stenosis grading,is stillthe main diagnostic index provided'by most CCTA tests.Post-processing and interpretation of stenosis are 2 essential'steps that need to be performed bycardiovascular imaging professionals from scan completion to diagnosis conclusion,which is repetitive and time-consuming,taking an average of 30 minutes each case in China and becoming the bottleneck and gradually creating an imbalance between supply and demand.In ine with the rapid development of artificial intelligence(Al)technology in recent years,it has been expected to solve these specific problems.We developed an AI system for automating post-processing and diagnostic reporting of CCTA data using deep learning algorithms to establishanew1-clickworkflowforeverydayuse,namely,CCTA-AI(Figure 1).To further assess its capabilities,this study intends to answer 2 following questions:To what extent can it improve the efficiency of post-processing?To what extent can CCTA-AI detect and calculate coronary artery stenosis due to each atherosclerotic plaque? | Nan Luo Yi He Jitao Fan Ning Guo Guang Yang Yuanyuan Kong Jianyong Wei Tao Bi Jie Zhou Jiaxin Cao Xianjun Han Fang Li Shiyu Zhang Rujing Sun Zhaozhao Wang Tian Ma Lixue Xu Hui Chen Hongwei Li Zhenchang Wang Zhenghan Yang | 2022 | Chinese Medical Journal2022，135，19： | 2 |
| 19 | High-resolution characterization of hexagonal boron nitride coatings exposed to aqueous and air oxidative environments显示文摘六角形的硼氮化物(h-BN ) 被相信由于它的绝缘的性质比 graphene 把更好的钝化提供给金属性的表面,它便于堵住电子的流动,从而阻止流电的反应的出现。不过,当 h-BN-protected 材料暴露于水的环境时,这不能是盒子。在这个工作,我们分析了暴露于 H 2 O 2 和大气的条件。当暴露了到 H 2 O 2 。多层的 h-BN 提供了保护的好度。单层 h-BN 被发现也在空气气氛无效。甚至 10-15 层厚的 h-BN 栈不能完全在考虑下面保护金属的表面。由联合钻电子光谱学和第二等的离子团 spectrometry 技术,我们观察到氧能通过 h-BN 栈的谷物边界扩散到达金属性的底层。因为这个过程的散开的性质,一旦一个浸透的状态被到达,幸好,氧化区域没与时间增加。这成为多层(不单层) h-BN 一个合适的长期的氧化障碍。氧渗入不能被 X 光检查光电子光谱学观察。这种技术不能估计材料的更深的层的化学作文。因此,以前的报告,依靠了 XPS 分析 h-BN 和 graphene 的使钝化的性质,可能忽略了一些重要表面下的现象。在这研究获得的结果在水的媒介和暴露于空气环境的 h-BN-coated 金属的降级动力学提供新卓见进单音、多层的 h-BN 的使钝化的性质。 | Lanlan Jiang Na Xiao Bingru Wang Enric Grustan-Gutierrez Xu Jing Petr Babor Miroslav Kogbal Guangyuan Lu Tianru Wu Haomin Wang Fei Hui Yuanyuan Shi Bo Song Xiaoming Xie Mario Lanza | 2017 | Nano Research2017，10，6： | 2 |
| 20 | Cytidine Mediated AuAg Nanoclusters as Bright Fluorescent Probe for Tumor Imaging in vivo显示文摘高贵金属聚类,避免大多数缺点是一个新兴的班荧光灯探针普通荧光灯混合物,和他们简单准备并且有好水溶解度,好 biocompatibility 和优秀荧光性质。在这研究,我们探索了 cytidine 的合成调停的金银的 nanoclusters (AuAg NC ) 并且在 vitro 为两个使用了它在 vivo 的细胞的成像和肿瘤察觉。试验性的结果证明同样准备的 AuAg NC 能是被使用一敏感荧光灯为癌症房间 / 织物的探查察觉。特别,在有 488 nm 的波长的相关轻照耀下面,显然明亮的荧光信号能乐意地从接种肿瘤老鼠的焦点地点被检测,是明显的,暗示它的可能的应用程序为在 vivo 肿瘤 bioimaging 有效。 | Leifeng Chen Yuanyuan Zhang Hui Jiang Xuemei Wang Chongyang Liu | 2016 | Chinese Journal of Chemistry2016，34，6： | 2 |
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