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| 1 | Clinical risk score for invasive fungal diseases in patients with hematological malignancies undergoing chemotherapy:China Assessment of Antifungal Therapy in Hematological Diseases (CAESAR) study显示文摘Invasive fungal disease (IFD) is a major infectious complication in patients with hematological malignancies.In this study,we examined 4889 courses of chemotherapy in patients with hematological diseases to establish a training dataset (n=3500) by simple random sampling to develop a weighted risk score for proven or probable IFD through multivariate regression,which included the following variables: male patients,induction chemotherapy for newly diagnosed or relapsed disease,neutropenia,neutropenia longer than 10 days,hypoalbuminemia,central-venous catheter,and history of IFD.The patients were classified into three groups,which had low (0-10,~1.2%),intermediate (11-15,6.4%),and high risk (> 15,17.5%) of IFD.In the validation set (n=1389),the IFD incidences of the groups were ~1.4%,5.0%,and 21.4%.In addition,we demonstrated that antifungal prophylaxis offered no benefits in low-risk patients,whereas benefits were documented in intermediate (2.1% vs.6.6%,P=0.007) and high-risk patients (8.4% vs.23.3%,P=0.007).To make the risk score applicable for clinical settings,a pre-chemo risk score that deleted all unpredictable factors before chemotherapy was established,and it confirmed that anti-fungal prophylaxis was beneficial in patients with intermediate and high risk of IFD.In conclusion,an objective,weighted risk score for IFD was developed,and it may be useful in guiding antifungal prophylaxis. | Ling Wang Ying Wang Jiong Hu Yuqian Sun He Huang Jing Chen Jianyong Li Jun Ma Juan Li Yingmin Liang Jianmin Wang Yan Li Kang Yu Jianda Hu Jie Jin Chun Wang Depei Wu Yang Xiao Xiaojun Huang | 2019 | Frontiers of Medicine2019，13，3： | 10 |
| 2 | Coupled relationships among anammox,denitrification, and dissimilatory nitrate reduction to ammonium along salinity gradients in a Chinese estuarine wetland显示文摘Salinization in estuarine wetlands significantly alters the balance between their nitrogen(N)removal and retention abilities but these processes have not yet been characterized effectively.In the present study,the potential rates of sediment denitrification,anaerobic ammonium oxidation(anammox),and dissimilatory nitrate reduction to ammonium(DNRA)were mapped using N isotope tracing methods along salinity gradients across the Yellow River Delta wetland(YRDW)in China.The contribution of anammox to total dissimilatory N transformations in YRDW was merely 6.8%,whereas denitrification and DNRA contributed 52.3%and 40.9%,respectively.The potential rate of denitrification(5.82μmol/kg/h)decreased significantly along salinity gradients and markedly exceeded DNRA potential rate(2.7μmol/kg/h)in fresh wetlands,but was lower than that of DNRA in oligohaline wetlands(3.06 and 3.18μmol/kg/h,respectively).Moreover,a significantly positive relationship between salinity and DNRA/denitrification was obeserved,indicating that increased salinity may favor DNRA over denitrification.Furthermore,total sulfur(TS)content and ratio of total organic carbon to total nitrogen(C/N)increased with the salinity gradient and showed evident positive relationships with the DNRA/denitrification ratio.In this study,we proved that increased salinization resulted in the dominance of DNRA over denitrification,possible through the addition of S and alteration of the C/N in estuarine wetlands,leading to increased N retention in estuarine wetlands during salinization,which would enhance the eutrophication potential within wetlands and in downstream ecosystems. | Zijun Zhou Lei Ge Yufang Huang Yuqian Liu Siyang Wang | 2021 | Journal of Environmental Sciences2021，33，8： | 4 |
| 3 | High-Performance and Hysteresis-Free Perovskite Solar Cells Based on Rare-Earth-Doped SnO_(2) Mesoporous Scaffold显示文摘Tin oxide(SnO_(2)),as electron transport material to substitute titanium oxide(TiO_(2))in perovskite solar cells(PSCs),has aroused wide interests.However,the performance of the PSCs based on SnO_(2) is still hard to compete with the TiO_(2)-based devices.Herein,a novel strategy is designed to enhance the photovoltaic performance and long-term stability of PSCs by integrating rare-earth ions Ln^(3+)(Sc^(3+),Y^(3+),La^(3+))with SnO_(2) nanospheres as mesoporous scaffold.The doping of Ln promotes the formation of dense and large-sized perovskite crystals,which facilitate interfacial contact of electron transport layer/perovskite layer and improve charge transport dynamics.Ln dopant optimizes the energy level of perovskite layer,reduces the charge transport resistance,and mitigates the trap state density.As a result,the optimized mesoporous PSC achieves a champion power conversion efficiency(PCE)of 20.63%without hysteresis,while the undoped PSC obtains an efficiency of 19.01%.The investigation demonstrates that the rare-earth doping is low-cost and effective method to improve the photovoltaic performance of SnO_(2)-based PSCs. | Qiyao Guo Jihuai Wu Yuqian Yang Xuping Liu Zhang Lan Jianming Lin Miaoliang Huang Yuelin Wei Jia Dong Jinbiao Jia Yunfang Huang | 2019 | Research2019，，1： | 3 |
| 4 | A novel pathogenic mutation in FBN2 associated with congenital contractural arachnodactyly for preimplantation genetic diagnosis显示文摘Congenital contractural arachnodactyly(CCA,OMIM:121050),also known as Beals syndrome,belongs to a group of rare autosomal dominant(AD)diseases of connective tissue(Maslen et al.,1997).People with CCA share many distinguishing features,such as arachnodactyly,camp tod actyly,multiple joint contractures(especially finger,elbow,and knee joints),crumpled ears,scoliosis,pectus deformities,and muscular hypoplasia(Jurko et al.,2013).It exhibits no specific geographic or ethnic predilection(Frederic et al.,2009). | Jiaxin Li Yuqian Wang Xiaohui Zhu Yanli Nie Ying Kuo Shuo Guan Jin Huang Ying Lian Yangyu Zhao Rong Li Yuan Wei Jie Qiao Liying Yan | 2020 | Journal of Genetics and Genomics2020，47，5： | 2 |
| 5 | Insulin sensitivity,βcell function,and adverse pregnancy outcomes in women with gestational diabetes显示文摘Background: The potential impact of β cell function and insulin sensitivity on adverse pregnancy outcomes in women with gestational diabetes mellitus (GDM) remains uncertain. We aimed to investigate the association between β cell dysfunction, insulin resistance, and the composite adverse pregnancy outcomes.Methods: This observational study included 482 women diagnosed with GDM during pregnancy. Quantitative metrics on β cell function and insulin sensitivity during pregnancy were calculated using traditional equations. The association of β cell dysfunction and insulin resistance with the risk of the composite adverse pregnancy outcomes was investigated using multivariable-adjusted logistic regression models.Results: Multivariable-adjusted odds ratios (ORs) of adverse pregnancy outcomes across quartiles of homeostatic model assessment for insulin resistance (HOMA-IR) were 1.00, 0.95, 1.34, and 2.25, respectively (P for trend = 0.011). When HOMA-IR was considered as a continuous variable, the multivariable-adjusted OR of adverse pregnancy outcomes was 1.34 (95% confidence interval 1.16-1.56) for each 1-unit increase in HOMA-IR. Multivariable-adjusted ORs of adverse pregnancy outcomes across quartiles of homeostatic model assessment for β cell function (HOMA-β) were 1.00, 0.51, 0.60, and 0.53, respectively (P for trend = 0.068). When HOMA-β was considered as a continuous variable, the multivariable-adjusted OR of adverse pregnancy outcomes was 0.57 (95% CI 0.24-0.90) for each 1-unit increase in HOMA-β. However, other quantitative metrics were not associated with the composite adverse pregnancy outcomes.Conclusions: We demonstrated a significant association of β cell function and insulin sensitivity with the risk of adverse pregnancy outcomes. We have provided additional evidence on the early identification of adverse pregnancy outcomes besides the glycemic values. | Yun Shen Yanwei Zheng Yingying Su Susu Jiang Xiaojing Ma Jiangshan Hu Changbin Li Yajuan Huang Yincheng Teng Yuqian Bao Minfang Tao Jian Zhou | 2022 | Chinese Medical Journal2022，135，21： | 2 |
| 6 | Reductive damage induced autophagy inhibition for tumor therapy显示文摘Numerous therapeutic anti-tumor strategies have been developed in recent decades.However,their therapeutic efficacy is reduced by the intrinsic protective autophagy of tumors.Autophagy plays a key role in tumorigenesis and tumor treatment,in which the overproduction of reactive oxygen species(ROS)is recognized as the direct cause of protective autophagy.Only a few molecules have been employed as autophagy inhibitors in tumor therapy to reduce protective autophagy.Among them,hydroxychloroquine is the most commonly used autophagy inhibitor in clinics,but it is severely limited by its high therapeutic dose,significant toxicity,poor reversal efficacy,and nonspecific action.Herein,we demonstrate a reductive-damage strategy to enable tumor therapy by the inhibition of protective autophagy via the catalytic scavenging of ROS using porous nanorods of ceria(PN-CeO_(2))nanozymes as autophagy inhibitor.The antineoplastic effects of PN-CeO_(2)were mediated by its high reductive activity for intratumoral ROS degradation,thereby inhibiting protective autophagy and activating apoptosis by suppressing the activities of phosphatidylinositide 3-kinase/protein kinase B and p38 mitogen-activated protein kinase pathways in human cutaneous squamous cell carcinoma.Further investigation highlighted PN-CeO_(2)as a safe and efficient anti-tumor autophagy inhibitor.Overall,this study presents a reductive-damage strategy as a promising anti-tumor approach that catalytically inhibits autophagy and activates the intrinsic antioxidant pathways of tumor cells and also shows its potential for the therapy of other autophagy-related diseases. | Yuqian Wang Yingjian Huang Yu Fu Zhixiong Guo Da Chen Fangxian Cao Qi Ye Qiqi Duan Meng Liu Ning Wang Dan Han Chaoyi Qu Zhimin Tian Yongquan Qu Yan Zheng | 2023 | Nano Research2023，16，4： | 1 |
| 7 | Second unmanipulated allogeneic transplantation could be used as a salvage option for patients with relapsed acute leukemia post-chemotherapy plus modified donor lymphocyte infusion显示文摘Relapse is the main problem after allogeneic hematopoietic stem cell transplantation(allo-HSCT).The outcome of a second allo-HSCT(HSCT2)for relapse post-HSCT has shown promising results in some previous studies.However,little is known about the efficacy of HSCT2 in patients with relapsed/refractory acute leukemia(AL)post-chemotherapy plus modified donor lymphocyte infusion(post-Chemo+m-DLI)after the first allo-HSCT(HSCT1).Therefore,we retrospectively analyzed the efficacy of HSCT2 in 28 patients with relapsed/refractory AL post-Chemo+m-DLI in our center.With a median follow-up of 918(457–1732)days,26 patients(92.9%)achieved complete remission,and 2 patients exhibited persistent disease.The probabilities of overall survival(OS)and disease-free survival(DFS)1 year after HSCT2 were 25.0%and 21.4%,respectively.The cumulative incidences of nonrelapse mortality on day 100 and at 1 year post-HSCT2 were 7.1%±4.9%and 25.0%±8.4%.The cumulative incidences of relapse were 50.0%±9.8%and 53.5%±9.9%at 1 and 2 years post-HSCT2,respectively.Risk stratification prior to HSCT1 and percentage of blasts before HSCT2 were independent risk factors for OS post-HSCT2,and relapse within 6 months post-HSCT1 was an independent risk factor for DFS and relapse post-HSCT2.Our findings suggest that HSCT2 could be a salvage option for patients with relapsed AL post-Chemo+m-DLI. | Tingting Han Yuqian Sun Yang Liu Chenhua Yan Yu Wang Lanping Xu Kaiyan Liu Xiaojun Huang Xiaohui Zhang | 2021 | Frontiers of Medicine2021，15，5： | 1 |
| 8 | A Specific Peptide Vaccine Against IDH1(R132H) Glioma显示文摘Malignant tumors of the central nervous system(CNS)have the poorest prognosis among the cancers.Gliomas are the most commonly occurring tumors of the CNS[1],accounting for almost 30%of all primary brain tumors and 80%of all malignant brain tumors[2].In 2016,the World Health Organization(WHO)assigned gliomas into four grades(I-IV)based on molecular parameters and light microscopic features[3];WHO grade I is the least malignant while grade IV is the worst.Glioma cells are believed to be derived from neuroglial stem or progenitor cells,and are characterized by active growth,strong invasion and rapid migration.Based on morphological similarities to the neuroglial cell types found in the normal brain,gliomas are histologically classified into astrocytomas,oligodendrogliomas,mixed oligoastrocytic gliomas,and ependymomas. | Yuqian Huang Yongjie Wang Zhihui Huang | 2022 | Neuroscience Bulletin2022，38，2： | 1 |
| 9 | Isobaric vapor–liquid equilibrium for binary system of aniline+methyl-N-phenyl carbamate显示文摘In this study,the quasi-static ebulliometric method was used to measure both of the vapor pressures of methyl N-phenyl carbamate(MPC),and the isobaric vapor–liquid equilibrium(VLE) data of the aniline and MPC binary system.The measured vapor pressure data of MPC,at different temperature ranging from 369.60 to 389.54 K,fitted well with the Antoine equation.The VLE data for the aniline and MPC system at(2.00,4.00,6.00,7.00 and 8.00) k Pa were correlated by both of nonrandom two-liquid(NRTL) and Wilson models.The parameters of the two models were obtained by regressing the experimental data,with the absolute temperature deviations of 0.54 K and 0.53 K,respectively.The relative volatility of the binary system calculated was all far more than 1,which gives the conclusion that the high purity MPC can be separated from aniline and MPC binary system by rectification or distillation technology. | Yuqian Li Liguo Wang Peng He Kelin Huang Huiquan Li Yan Cao | 2016 | Chinese Journal of Chemical Engineering2016，24，10： | 1 |
| 10 | Gypenoside, the Main Active Compound of Gynostemma pentaphyllum , Mitigates the Diabetic Nephropathy through Down-regulating mTOR显示文摘Background:Diabetic nephropathy(DN),as a complication of diabetes,is featured with hypertension,hyper-glycemia,proteinuria and edema.Gypenoside(GP),the main active compound of Gynostemma pentaphyllum,is proved to be effective for DN.In our previous research,we found that GP could protect the glomerulus and re-duce proteinuria by up-regulating the expression of nestin and down-regulating TGFB1.However,the panoramic mechanism of GP against DN is still unclear.Objective:This research is designed to reveal the mechanism of GP on DN through network pharmacology and in vivo and in vitro experimental verification.Methods:In this study,active compounds and targets of Gynostemma pentaphyllum were collected from TCMSP.DisGeNET was used for obtaining the targets of DN.The protein-protein interaction network was acquired from the STRING database and analyzed by the MCODE plugin.GO and KEGG enrichment analysis were constructed to explore further information.In vivo and in vitro experiments were also carried out to evaluate the reliability of this study.Western blotting and RT-PCR were used to detect mTOR,4E-BP1,p70s6k protein expression and Mtor mRNA expression in DN rats,respectively.AKT1,TP53,ESR1 and PTEN protein expression in MPC-5 cells were detected by Western blotting.Results:Twenty-four compounds and 217 targets were selected from Gynostemma pentaphyllum,of which 36 targets overlapped with DN were taken for the potential targets.The results showed that Quercetin,Rhamnazin,Isofucosterol and 3′-methyleriodictyol corresponded to more targets,AKT1,TP53,MYC,ESR1,PTEN were more active.36 potential targets were mainly involved in autoimmunity,inflammatory response,metabolism and autophagy.In vivo and in vitro experiments showed that GP might protect the podocytes of DN rats by decreasing the protein expression of mTOR,4EBP1,p70s6k,as well as the mRNA expression of Mtor,and it had the function in regulating the potential targets through decreasing the protein expression of AKT1,TP53 and ESR1 and increasing the expression of PTEN.Conclusion:This research demonstrates that various compounds of Gynostemma pentaphyllum may intervenes in DN through targets of multiple signaling pathways,which involves a large number of biological processes.It can provide novel insights for further research of the mechanism of GP in the treatment of DN. | Chao Chen Danqing Fu Yuqian Wu Chen Huang Ping Huang | 2023 | Clinical Complementary Medicine and Pharmacology2023，3，2： | 0 |
| 11 | Influence of the degree of donor bone marrow hyperplasia on patient clinical outcomes after allogeneic hematopoietic stem cell transplantation显示文摘This study evaluated the influence of the degree of donor bone marrow(BM)hyperplasia on patient clinical outcomes after allogeneic hematopoietic stem cell transplantation(allo-HSCT).Twelve patients received allo-HSCT from hypoplastic BM donors between January 2010 and December 2017.Forty-eight patients whose donors demonstrated BM hyperplasia were selected using a propensity score matching method(1:4).Primary graft failure including poor graft function and graft rejection did not occur in two groups.In BM hypoplasia and hyperplasia groups,the cumulative incidence(CI)of neutrophil engraftment at day 28(91.7%vs.93.8%,P=0.75),platelet engraftment at day 150(83.3%vs.93.8%,P=0.48),the median time to myeloid engraftment(14 days vs.14 days,P=0.85)and platelet engraftment(14 days vs.14 days,P=0.85)were comparable.The 3-year progression-free survival,overall survival,CI of non-relapse mortality and relapse were 67.8%vs.71.7%(P=0.98),69.8%vs.77.8%(P=0.69),18.5%vs.13.6%(P=0.66),and 10.2%vs.10.4%(P=0.82),respectively.In multivariate analysis,donor BM hypoplasia did not affect patient clinical outcomes after allo-HSCT.If patients have no other suitable donor,a donor with BM hypoplasia can be used for patients receiving allo-HSCT if the donor Complete Blood Count and other examinations are normal. | Feifei Tang Xiaodong Mo Xiaohui Zhang Yu Wang Chenhua Yan Yuhong Chen Huan Chen Wei Han Yao Chen Fengrong Wang Jingzhi Wang Yuqian Sun Yuanyuan Zhang Kaiyan Liu Xiaojun Huang Lanping Xu | 2020 | Science China(Life Sciences)2020，63，1： | 0 |
| 12 | Moon appreciation increases popularity of night tour显示文摘The tradition of appreciating the moon has greatly driven the popularity of the night tour market in Wuhan during the past Mid-Autumn Festival holiday.To express the emotions of reunions,some people enjoyed various flavors of mooncakes,some went to the Yellow Crane Tower to take pictures of the moon and the ancient structure,while others went camping and experienced folk activities at suburban scenic spots. | Huang Lijuan Ye Feiyan Hou Yuqian | 2022 | Changjiang Weekly2022，，36： | 0 |
| 13 | Evaporated potassium chloride for double-sided interfacial passivation in inverted planar perovskite solar cells显示文摘Defect-induced charge carrier recombination at the interfaces between perovskite and adjacent charge transport layers restricts further improvements in the device performance of perovskite solar cells(PSCs).Defect passivation at these interfaces can reduce trap states and inhibit the induced nonradiative recombination.Herein,we report a double-sided interfacial passivation via simply evaporating potassium chloride(DIP-KCl)at both the hole transport layer(HTL)/perovskite and perovskite/electron transport layer(ETL)interfaces in inverted planar PSCs.We demonstrate that the bottom KCl layer at the HTL/perovskite interface not only reduces the interfacial defects and improves the interfacial contact,but also leads to increased perovskite crystallinity,while the top KCl layer at the perovskite/ETL interface efficiently passivates the perovskite top surface defects and facilitates electron extraction at this interface.Thus,suppressed nonradiative recombination and faster charge extraction at both interfaces close to the perovskite layer can be achieved by using our DIP-KCl strategy.As a result,inverted PSCs based on DIP-KCl present an increased efficiency from 17.1% to 19.2% and enhanced stability,retaining over 90% of their initial efficiency after aging at maximum power point tracking for 1000 h.This work provides a simple and efficient way for defect passivation to further increase the efficiency and stability of PSCs. | Shasha Zhang Xiaobo Yan Zonghao Liu Hongmei Zhu Zhichun Yang Yuqian Huang Sanwan Liu Di Wu Ming Pan Wei Chen | 2021 | Journal of Energy Chemistry2021，30，3： | 0 |
| 14 | The impacts of fabrication systems on 3D concrete printing building forms显示文摘Recently,3D concrete printing(3DCP)technology starts entering the market from factories and laboratories,contributing to the creation of new construction methods and architectural forms.However,since the technologies of most 3DCP institutions are independently developed,there is a lack of consensus in terms of construction methods and development approaches in the industry.In this paper,based on 423DCP architectural works completed in last five years,a quantitative analysis was made to evaluate the impacts of the fabrication system on 3DCP building forms.The paper introduced three criteria,including Workspace Index,Geometric Complexity Index,and Tectonic Prospect Index,analyzing and answering the discussions about'adopting in-situ printing or prefabrication','using gantry printers or robotic arms'from the perspective of architectural form.By analyzing specific construction methods and design strategies in these projects,the research summarized three development trends,'mobile equipment,algorithmic structure,and intelligent construction',which will affect the future development of 3DCP building forms.Finally,the paper discussed the advantages,limitations,and potential of four different 3DCP fabrication systems,expecting to point out the directions to further optimize each system and realize more diverse 3DCP buildings. | Shuyi Huang Weiguo Xu Yuqian Li | 2022 | Frontiers of Architectural Research2022，11，4： | 0 |
| 15 | Size dependence of photovoltaic properties and surface states modulation in ZnO nanowire/poly(3-hexylthiophene) hybrid nanostructures显示文摘适当直径和 wire-to-wire 距离为优化混合无机 / 器官的光电的设备的表演是批评的。为他们对如此的混合结构的影响的深理解,有不同直径的秩序井然的 ZnO nanowires 被万用的热水的生长制作。表面状态,电线直径和 wire-to-wire 距离上的光电的表演的依赖被调查。我们证明太古的厚 ZnO nanowires 电影拥有更高的表面 photovoltage (SPV ) 反应比薄的。这主要由于对薄 ZnO nanowires 的表面状态的影响,它能捕获产生相片的搬运人。当二种 ZnO nanowires 被制作进混合无机 / 器官的结构时,薄 ZnO nanowires/poly (3-hexylthiophene ) 混血儿电影比厚的有更高的 SPV 回答,它与太古的 ZnO nanowires 相反。这从更小的直径和拥有的薄 ZnO nanowires 的 wire-to-wire 距离被有益于。crystallinity,电线直径和 wire-to-wire 距离在最后的光电的表演上有关键影响。这里显示出的结果向设计有效混合光电的设备给我们卓见。 | Yuqian Huang Ke Cheng Jingjing Liu Ming Xue Zhongcheng Kuang Zuliang Du | 2016 | Science Bulletin2016，61，3： | 0 |
| 16 | Enrichment of Cd and Pb and associations with grain size in sediments in Nanjing alluvial island of Yangtze River显示文摘 | Hongrui MA Yuqian MAO Junfeng JI Qiling LIAO Shunsheng HUANG | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 0 |
| 17 | DUB3通过去泛素化BRD4促进BET抑制剂抗性和癌症进展显示文摘文章简介BRD4是Bromo结构域和末端结构域(BET)蛋白家族的成员。除了与乙酰化组蛋白相互作用外,BRD4还被证明通过以癌症类型特异性方式与转录因子物理和/或功能相互作用来促进癌症进展。这些发现强调BRD4是一种有前景的癌症治疗靶点。 | Xin Jin Yuqian Yan Dejie Wang Donglin Ding Tao Ma Zhenqing Ye Rafael Jimenez Liguo Wang 吴河水 Haojie Huang | 2019 | 科学新闻2019，0，2： | 0 |
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