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| 1 | Drug resistance mutation profiles of the drug-nave and first-line regimen-treated HIV-1-infected population of Suzhou, China显示文摘Little is known about the prevalence of drug-resistant mutations in HIV-1-positive individuals in Suzhou, China. To elucidate the transmitted drug resistance(TDR) and acquired drug resistance mutation(ADR) profiles, we collected blood specimens from 127 drug-naive and 117 first-line drugtreated HIV-1-infected individuals sampled from 2014 to 2016 in Suzhou. We successfully amplified po/fragments from 100 drug-naive and 20 drug-treated samples. We then determined the drugresistant mutations to protease(PR) and reverse-transcriptase(RT) inhibitors according to the Stanford drug resistance database. Overall, 11 and 13 individuals had transmitted(drug-naive group) and acquired(treated group) resistance mutations, respectively. Six transmitted drugresistant mutations were found, including two mutations(L33F and L76V) in the protease region and four(K70N/E and V179D/E) in the RT region. Only L76 V was a major mutation, and K70N/E and V179D/E are known to cause low-level resistance to RT inhibitors. All 13 treated participants who had major drug resistance mutations demonstrated intermediate to high resistance to efavirenz and nevirapine, and six had a treatment duration of less than three months. No major mutations to RT inhibitors were found, implying that the epidemic of transmitted resistance mutations was not significant in this area. Our results suggest that more frequent virus load and drug resistance mutation tests should be conducted for individuals receiving antiretroviral treatment, especially for newly treated patients. Our research provides insights into the occurrence of HIV-1 drug resistance in Suzhou and will help to optimize the treatment strategy for this population. | Tingting Li Feng Qian Ting Yuan Weilu Xu Li Zhu Jinlong Huang Haiyan Wang Yueping Zhu Yinling Wang Xiaohong Li Saihong Gu Zhuqing Tan Hui Chen Xiangrong Luo Wei Zhu Weniuan Lu Ping Xu Ming Li Yuying Chen Yong Gao Rongge Yang Chuanwu Zhu Binlian Sun | 2017 | Virologica Sinica2017，32，4： | 2 |
| 2 | Broadband radio spectral observations of the solar eclipse on 2008-08-01 and its implications on the quiet Sun atmospheric model显示文摘Based on the joint-observations of the radio broadband spectral emissions of the solar eclipse on August 1, 2008 at Jiuquan (total eclipse) and Huairou (partial eclipse) at the frequencies of 2.00-5.60 GHz (Jiuquan), 2.60-3.80 GHz (Chinese solar broadband radiospectrometer, SBRS/Huairou), and 5.20-7.60 GHz (SBRS/Huairou), the authors assemble a successive series of broadband spectra with a frequency of 2.60-7.60 GHz to observe the solar eclipse synchronously. This is the first attempt to analyze the solar eclipse radio emission under the two telescopes located at different places with broadband frequencies in the periods of total and partial eclipses. With these analyses, the authors made a semiempirical model of the coronal plasma density of the quiet Sun, which can be expressed as ne 1.42×109(r-2+1.93r-5) (cm-3), in the space range of r=1.039-1.212 R , and made a comparison with the classic model. | TAN BaoLin YAN YiHua ZHANG Yin TAN ChengMin HUANG Jing LIU YuYing FU QiJun CHEN ZhiJun LIU Fei CHEN LinJie JI GuoShu | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，11： | 2 |
| 3 | A highly sensitive single - enzyme homocysteine assay 显示文摘 | Yuying Tan Robert M Hoffman | 2008 | Nature protocols2008，3，： | 1 |
| 4 | Metastatic patterns of lung cancer visualized live and in process by green fluorescence protein expression显示文摘 | Takashi Chishima Yohei Miyagi Xiaoen Wang Eugene Baranov Yuying Tan Hiroshi Shimada A.R. Moossa Robert M. Hoffman | 1997 | Clinical and Experimental Metastasis1997，，5： | 1 |
| 5 | A New Solar Broadband Radio Spectrometer (SBRS) in China显示文摘 | Qijun Fu Huirong Ji Zihai Qin Zhicai Xu Zhiguo Xia Hongao Wu Yuying Liu Yihua Yan Guangli Huang Zhijun Chen Zhenyu Jin Qijun Yao Congling Cheng Fuying Xu Min Wang Libei Pei Shanhuai Chen Guo Yang Chenming Tan Suobiao Shi | 2004 | Solar Physics2004，，1： | 1 |
| 6 | Determination of effective shear modulus of shock-compressed LY12 A1 from particle velocity profile measurements显示文摘 | Yu Yuying Tan Hua Hu Jianbo | 2008 | Journal of Applied Physics2008，103，10： | 1 |
| 7 | A Solar Radio Spectrometer at 5.2–7.6?GHz显示文摘 | Huirong Ji Qijun Fu Yuying Liu Congling Cheng Zhijun Chen Yihua Yan Leping Zheng Zongjun Ning Chengmin Tan Debang Lao Shuke Li Jiyong Gao Zhiqiang Wang Minhong Yu | 2003 | Solar Physics2003，，2： | 1 |
| 8 | Synergistic effects of focus ultrasound with different frequency and hematoprphyrin on human tumor cells显示文摘 | Hao Qi Shengjiang Tan Yuying Ma Cunniu Song | 1998 | Science in China Series C: Life Sciences1998，，5： | 1 |
| 9 | Overexpression and large-scale production of recombinant L-Methionine-a-deamino-γ-gmercaptomethane - lyase for novel anticancer therapy显示文摘 | Yuying Tan Mingxu Xu Xuezhong Tan Xiuying Tan Xiaoen Wang Yoshiro Saikawa Takeshi Nagahama Xinghua Sun Martin Lenz and Robert M Hoffman | 1997 | Protain expression and purification1997，9，： | 1 |
| 10 | How Well Do CMIP6 and CMIP5 Models Simulate the Climatological Seasonal Variations in Ocean Salinity?显示文摘This paper includes a comprehensive assessment of 40 models from the Coupled Model Intercomparison Project phase 5(CMIP5)and 33 models from the CMIP phase 6(CMIP6)to determine the climatological and seasonal variation of ocean salinity from the surface to 2000 m.The general pattern of the ocean salinity climatology can be simulated by both the CMIP5 and CMIP6 models from the surface to 2000-m depth.However,this study shows an increased fresh bias in the surface and subsurface salinity in the CMIP6 multimodel mean,with a global average of−0.44 g kg^(−1) for the sea surface salinity(SSS)and−0.26 g kg^(−1) for the 0-1000-m averaged salinity(S1000)compared with the CMIP5 multimodel mean(−0.25 g kg^(−1) for the SSS and−0.07 g kg^(−1) for the S1000).In terms of the seasonal variation,both CMIP6 and CMIP5 models show positive(negative)anomalies in the first(second)half of the year in the global average SSS and S1000.The model-simulated variation in SSS is consistent with the observations,but not for S1000,suggesting a substantial uncertainty in simulating and understanding the seasonal variation in subsurface salinity.The CMIP5 and CMIP6 models overestimate the magnitude of the seasonal variation of the SSS in the tropics in the region 20°S-20°N but underestimate the magnitude of the seasonal change in S1000 in the Atlantic and Indian oceans.These assessments show new features of the model errors in simulating ocean salinity and support further studies of the global hydrological cycle. | Yuanxin LIU Lijing CHENG Yuying PAN Zhetao TAN John ABRAHAM Bin ZHANG Jiang ZHU Junqiang SONG | 2022 | Advances in Atmospheric Sciences2022，39，10： | 0 |
| 11 | Effects of Dietary Picria felterrae Lour Extracts on Serum Biochemical Indexes and Immune Function of Guangxi Partridge Chickens显示文摘[Objective] This trial was to investigate the effect of dietary Picria felterrae Lour extracts on serum biochemical indexes and immune function of Guangxi Partridge chickens. [Method] Totally 500 individuals of 1-day-old Guangxi Partridge chickens were randomly divided into five groups, five replicates each group and 20 chicks each replicate. Groups A, B and C were treatment groups supplemented with 0.70%, 0.35% and0.175% P. felterrae extracts in the basal diet, respectively; group D was a medical control group supplemented with 0.01% colistin sulfate premix in the basal diet; and group E was a control group with basal diet. Serum samples were collected from 10 chickens in each group at 21, 35 and 49 days of age, to analyze the biochemical and immune indexes. [Result] It had no significant impact on serum TP and GLU contents of chickens by adding different levels of P. felterrae extracts in the basal diet(P >0.05). However, at 21 and 35 days of age, the TBILI content of chickens in groups A, B and C were extremely lower or significantly lower than that in group E( P<0.01; P<0.05). At 35 days of age, the serum AKP activities in groups A, B and C were extremely higher than that in group E(P<0.01), and the serum GOT activities at 21 and 35 days of age in group C were significantly higher than that in group E(P<0.05). At 49 days of age, the serum Ig G content in groups A, B and C and the IL-2 content in group B and group C were significantly lower or extremely lower than that in group E( P<0.05; P<0.01); the T-AOC content in group B was significantly higher than that in group E(P<0.05); the GSH content in groups A, B and C were significantly higher than that in group E( P<0.05). Adding different levels of P. felterrae extracts in the diet significantly decreased the TBILI content, reduced the Ig G, IL-2 and IL-6 contents, and improved the AKP and GOT activities and the T-AOC and GSH contents of Guangxi Partridge chicken. [Conclusion] Adding 0.35% P. felterrae extracts in the basal diet received the best effort. | Yang Cui Bi Xianda Hu Tingjun Yang Jian Huang Hongye Tan Honglian Peng Jianbo Luo Wenjuan Li Lu Li Chunjie Liao Yuying Yang Jiahuang | 2018 | Animal Husbandry and Feed Science2018，10，1： | 0 |
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