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| 1 | Pediatric reference intervals in China(PRINCE):design and rationale for a large,multicenter collaborative cross-sectional study显示文摘There is a lack of accurate pediatric reference intervals(RIs) in China, with most commonly used RIs established without consideration of the effect of age and gender. The Pediatric Reference Intervals in China(PRINCE) project aims to establish and verify pediatric RIs for 31 common laboratory measurands.The project will be a large, multicenter cross-sectional study:14,490 healthy children and adolescents aged up to 19 years will be surveyed by 10 children's hospitals and one pediatric department of a university hospital. To evaluate the feasibility and efficiency of the study methods, 602 children were surveyed in the pilot phase of the PRINCE study in April 2017: it found that some measurands were distinctly age dependent and that there were differences between values for males and females. The results of the pilot study affirmed the necessity of the PRINCE project for Chinese pediatrics. The pilot also indicated potential difficulties in the full survey, e.g., difficulties in recruiting children aged under 3 years and insufficient collection of blood samples from infants. The operation of the PRINCE project has been modified based on the findings in the pilot study toward improving the validity of the PRINCE project and promoting its openness and transparency. | Xin Ni Wenqi Song Xiaoxia Peng Ying Shen Yaguang Peng Qiliang Li Yan Wang Lixin Hu Yanying Cai Hong Shang Min Zhao Hong Jiang Yaoguo Huang Runqing Mu Wenxiang Chen Mingting Peng Chuanbao Zhang Jie Zeng Chenbin Li Hongling Yang Yongmei Jiang Jin Xu Guixia Li Hongbing Chen Yun Xiang Sancheng Cao Zhenxin Guo Dapeng Chen | 2018 | Science Bulletin2018，63，24： | 12 |
| 2 | iRGD decorated liposomes:A novel actively penetrating topical ocular drug delivery strategy显示文摘Ocular drug delivery remains a significant challenge that is limited by poor corneal retention and permeation,resulting in low ocular bioavailability(<5%).Worse still,the most convenient and safe route of ocular drug administration,topical administration results in a drug bioavailability of less than 1%.iRGD modified drug delivery strategies have been developed for cancer therapy,however active targeting iRGD platforms for ocular drug delivery have yet to be explored.Herein,an iRGD modified liposomes was developed for ocular drug delivery via topical administration.The results indicated that iRGD modified liposomes could prolong the corneal retention time and enhance corneal permeability in an iRGD receptor mediated manner.These findings provided a novel strategy for topical ocular drug delivery for the treatment of posterior ocular diseases. | Hai Huang Xiaorong Yang Huili Li Hansi Lu James Oswald Yongmei Liu Jun Zeng Chaohui Jin Xingchen Peng Jiyan Liu Xiangrong Song | 2020 | Nano Research2020，13，11： | 2 |
| 3 | Tailoring biochar by PHP towards the oxygenated functional groups(OFGs)-rich surface to improve adsorption performance显示文摘In this work,a modification method of H_(3)PO_(4)plus H_(2)O_(2)(PHP)was introduced to targetedly form abundant oxygenated functional groups(OFGs)on biochar,and methylene blue(MB)was employed as a model pollutant for adsorption to reflect the modification performance.Results indicated that parent biochars,especially derived from lower temperatures,substantially underwent oxidative modification by PHP,and OFGs were targetedly produced.Correspondingly,approximately 21.5-fold MB adsorption capacity was achieved by PHP-modified biochar comparing with its parent biochar.To evaluate the compatibility of PHP-modification,coefficient of variation(CV)based on MB adsorption capacity by the biochar from various precursors was calculated,in which the CV of PHP-modified biochars was 0.0038 comparing to0.64 of the corresponding parent biochars.These results suggested that the PHP method displayed the excellent feedstock compatibility on biochar modification.The maximum MB adsorption capacity was454.1 mg/g when the H_(3)PO_(4)and H_(2)O_(2)fraction in PHP were 65.2%and 7.0%;the modification was further intensified by promoting temperature and duration.Besides,average 94.5%H_(3)PO_(4)was recovered after 10-batch modification,implying 1.0 kg H_(3)PO_(4)(85%)in PHP can maximally modify 2.37 kg biochar.Overall,this work offered a novel method to tailor biochar towards OFGs-rich surface for efficient adsorption. | Xinyue Xiong Zhanglin Liu Li Zhao Mei Huang Lichun Dai Dong Tian Jianmei Zou Yongmei Zeng Jinguang Hu Fei Shen | 2022 | Chinese Chemical Letters2022，33，6： | 1 |
| 4 | Bioethanol production from sweet sorghum stalk juice with immobilized yeast显示文摘 | Fei Shen Yongmei Zeng Shihuai Deng Ronghou Liu | 2011 | Procedia Environmental Sciences2011，，： | 1 |
| 5 | Sorption and biodegradation of 17β-estradiol by acclimated aerobic activated sludge and isolation of the bacterial strain显示文摘 | ZENG Qingling LI Yongmei GU Guowei | 2009 | Environmental Engineering Science2009，26，4： | 1 |
| 6 | Efficacy and Safety of Dexamethasone Ointment on Recurrent Aphthous Ulceration显示文摘 | Chuanxia Liu Zengtong Zhou Guanjian Liu Qintao Wang Jiangang Chen Ling Wang Yongmei Zhou Guangying Dong Xueyi Xu Yuechun Wang Yiqing Guo Mei Lin Lan Wu Gefei Du Changlei Wei Xin Zeng Xiaoyi Wang Junzheng Wu Bingqi Li Gang Zhou Hongmei Zhou | 2012 | The American Journal of Medicine2012，，3： | 1 |
| 7 | Elucidating dominant factors of PO43–, Cd2+ and nitrobenzene removal by biochar: A comparative investigation based on distinguishable biochars显示文摘Biochars produced from crab shell(CSB),oak sawdust(OB),Jeru salem artichoke tuber(JAB) and sorghum grain(SB) displayed distinguishable adsorption-related characteristics,such as specific surface area(SSA),ash content and acidic oxygen-containing functional groups(AFGs),which linked to the biochar adsorption mechanisms of most pollutants.Herein,PO4^3-,Cd^2+,and nitrobenzene(NB) were employed for adsorption by these biochars to elucidate the dominant factors for the adsorption.Adsorption performance of the three pollutants onto these four biochars varied considerably,as exemplified by the excellent adsorption of PO4^3- and Cd^2+ onto CSB(225.3 and 116.0 mg/g,respectively) as compared with onto the other three biochars(4.2-37.1 mg/g for P043-and 9.7-41.0 mg/g for Cd^2+).OB displayed the best adsorption of NB(72.0 mg/g),followed by SB(39.5 mg/g),JAB(31.1 mg/g),and CSB(23.6 mg/g).The kinetics and isotherm adsorption assessments couple with material characterization suggested that the sorption of selected pollutants on biochars was attributed to the multiple mechanisms involved,including coprecipitation,chemical bonds,cation exchange,physical absorption,and complexation.Further path analysis suggested that AFGs and ash content in biochars were more important than SSA with regards to pollutant removal,especially,with ash playing a crucial role in the removal of Cd2+ and PO43-,and AFGs being mainly re s ponsible for NB adsorption.These findings might offer guidance on the preparation or modification of biochar with a targeted function for pollutant removal through an understanding the dominant factors. | Zhanglin Liu Dong Tian Fei Shen Lulu Long Yanzong Zhang Gang Yang Yongmei Zeng Jing Zhang Jinsong He Ying Zhu Shihuai Deng | 2019 | Chinese Chemical Letters2019，30，12： | 0 |
| 8 | p-Norm Broad Learning for Negative Emotion Classification in Social Networks显示文摘Negative emotion classification refers to the automatic classification of negative emotion of texts in social networks.Most existing methods are based on deep learning models,facing challenges such as complex structures and too many hyperparameters.To meet these challenges,in this paper,we propose a method for negative emotion classification utilizing a Robustly Optimized BERT Pretraining Approach(RoBERTa)and p-norm Broad Learning(p-BL).Specifically,there are mainly three contributions in this paper.Firstly,we fine-tune the RoBERTa to adapt it to the task of negative emotion classification.Then,we employ the fine-tuned RoBERTa to extract features of original texts and generate sentence vectors.Secondly,we adopt p-BL to construct a classifier and then predict negative emotions of texts using the classifier.Compared with deep learning models,p-BL has advantages such as a simple structure that is only 3-layer and fewer parameters to be trained.Moreover,it can suppress the adverse effects of more outliers and noise in data by flexibly changing the value of p.Thirdly,we conduct extensive experiments on the public datasets,and the experimental results show that our proposed method outperforms the baseline methods on the tested datasets. | Guanghao Chen Sancheng Peng Rong Zeng Zhongwang Hu Lihong Cao Yongmei Zhou Zhouhao Ouyang Xiangyu Nie | 2022 | Big Data Mining and Analytics2022，5，3： | 0 |
| 9 | Inhibition of native arbuscular mycorrhizal fungi induced increases in cadmium loss via surface runoff and interflow from farmland显示文摘Arbuscular mycorrhizal fungi(AMF)can form symbiotic relationships with most crops,but their impact on the environmental migration of cadmium(Cd)in farmland is limited.A field experiment was per-formed in the rainy season(May-October)for two years in Cd-polluted farmland used for maize cultivation.A fungicide(benomyl)was used to specifically inhibit native AMF growth in the farmland.The growth and Cd uptake of maize and the Cd concentration and loss in runoff and interflow were investigated.Benomyl strongly and significantly inhibited AMF colonization rate in maize roots,reduced the contents of total and easily extractable glomalin-related soil protein(GRSP)in soil and the Cd uptake in maize roots,and increased the Cd uptake in shoots.Particulate Cd was the main form of Cd loss in runoff,while dissolved Cd was the main form of Cd leaching loss at depths of 20 cm and 40 cm.Inhibiting AMF increased the Cd concentration in runoff and interflow and promoted dissolved Cd loss in runoff and interflow at 20 cm depth by 34.7%and 68.0%and particulate Cd loss by 46.4%and 19.7%,respectively.Furthermore,the AMF colonization rate in maize roots and the GRSP content in soil were significantly positively correlated with Cd uptake in roots and negatively correlated with the concentration and loss of Cd in runoff and interflow.These results indicated that the benomyl-induced inhibition of native AMF promoted Cd transfer to maize shoots and increased Cd loss via runoff and interflow from polluted farmland. | Fangdong Zhan Wenzeng Zeng Bo Li Zuran Li Jjianjun Chen Yongmei He Yuan Li | 2023 | International Soil and Water Conservation Research2023，11，1： | 0 |
| 10 | Transcriptome Analysis of Pacific White Shrimp(Litopenaeus vannamei)Hepatopancreas in Response to Taura Syndrome Virus(TSV)Experimental Infection显示文摘 | Digang Zeng Xiuli Chen Daxiang Xie Yongzhen Zhao Chunling Yang Yongmei Li Ning Ma Min Peng Qiong Yang Zhenping Liao Hui Wang Xiaohan Chen | 2014 | 广西水产科技2014，，1： | 0 |
| 11 | CACA Guidelines for Holistic Integrative Management of Breast Cancer显示文摘Purpose:Breast cancer is now the most common malignant tumor worldwide.About one-fourth of female cancer patients all over the world sufer from breast cancer.And about one in six female cancer deaths worldwide is caused by breast cancer.In terms of absolute numbers of cases and deaths,China ranks frst in the world.The CACA Guidelines for Holistic Integrative Management of Breast Cancer were edited to help improve the diagnosis and comprehensive treatment in China.Methods:The Grading of Recommendations Assessment,Development and Evaluation(GRADE)was used to classify evidence and consensus.Results:The CACA Guidelines for Holistic Integrative Management of Breast Cancer include the epidemiology of breast cancer,breast cancer screening,breast cancer diagnosis,early breast cancer treatment,advanced breast cancer treatment,follow-up,rehabilitation,and traditional Chinese medicine treatment of breast cancer patients.Conclusion:We to standardize the diagnosis and treatment of breast cancer in China through the formulation of the CACA Guidelines. | Jiong Wu Daiming Fan Zhimin Shao Binghe Xu Guosheng Ren Zefei Jiang Yongsheng Wang Feng Jin Jin Zhang Qingyuan Zhang Fei Ma Jinli Ma Zhonghua Wang Shusen Wang Xiaojia Wang Shu Wang Haibo Wang Tao Wang Xiang Wang Jing Wang Jia Wang Biyun Wang Li Fu Hongyuan Li Yehui Shi Lu Gan Yunjiang Liu Jian Liu Zhenzhen Liu Qiang Liu Qiang Sun Wenwu Cheng Keda Yu Zhongsheng Tong Xinhong Wu Chuangui Song Jianguo Zhang Jian Zhang Junjie Li Bin Li Man Li Huiping Li Wentao Yang Hongjian Yang Benlong Yang Hong Bu Juping Shen Zhenzhou Shen Yiding Chen Ceshi Chen Da Pang Zhimin Fan Ying Zheng Xiaoli Yu Guangyu Liu Xichun Hu Yiqun Ling Jinhai Tang Yongmei Yin Cuizhi Geng Peng Yuan Yajia Gu Cai Chang Xuchen Cao Yuan Sheng Yuanxi Huang Jian Huang Weijun Peng Xiaohua Zeng Yuntao Xie Ning Liao Committee of Breast Cancer Society,Chinese Anti-Cancer Association | 2022 | Holistic Integrative Oncology2022，1，1： | 0 |
| 12 | Germylene-Fe complexes caused by heterometallic coupling and investigation into the 3d-4p bonding显示文摘The interpretation of heterometallic bonding nature is a basic work of inorganic chemistry.By means of intermetallic substitution of germylene anions with iron halide complexes CpFe(CO)_(2)I andβ-diketiminato Fe^Ⅱchloride,the ferrogermylene complexes 3a,3b and 4a were synthesized and structurally characterized.The structural and IR characterizations show the presence of the Ge←Feπbackbonding in molecules 3a,3b and 4a.The computational works on frontier molecular orbitals and their comparison of energy states confirmed thatσdonation andπbackbonding are both weak in these molecules,despite three complexes have longer Ge-Fe bonds,whose strength decreases slightly with the degressive electron density around Fe environment in a sequence from 3a,3b to 4a. | Yingying Qin Yongmei Kang Lei Zhang Jianping Sun Zhijing Zhang Jialei Xu Fanlong Zeng Anyang Li Wenyuan Wang Weiqun Shi | 2024 | Chinese Chemical Letters2024，35，3： | 0 |
| 13 | Mapping of genetic modifiers of Plcd1 in scant hair mice(snthr^(1Bao))显示文摘The scant hair mutant mouse(locus symbol:snthr1Bao) is a recessive mutation that originated in an ethylnitrosourea chemical carcinogenesis study using the DBA/2J inbred strain.The gene responsible for the mutation was previously determined to be phospholipase C,delta 1(Plcd1;mutant allele symbol Plcd1snthr1Bao).To map the modifiers of Plcd1,an intercross(DBA/2J-snthr1Bao/snthr1Bao × C57BL/6J+/+) was conducted.The F2 mutant progeny exhibited a variety of alopecia phenotypes;all F2 mutants(n=507) were classified into 3 groups(mild,moderate,and severe alopecia) and genotyped based on 96 microsatellites.A major QTL was identified on mouse chromosome(mChr) 15 at 12 cM with an LOD score greater than 7(P < 0.0001).Three minor QTLs were detected on mChr 2,5,and 7 at 40,84 and 48 cM,respectively.The QTLs on mChr 7 and 15 were associated with minor alopecia while the QTLs on mChr 2 and 5 were associated with moderate to severe alopecia.No antagonistic or synergistic effects among or between the 4 QTLs were found.Integrating the functions of the 4 potential regulatory QTLs and mutant Plcd1snthr1Bao,we found that these QTLs might contribute to variations of scant hair severity by altering the Ca2+ signal pathways in mouse skin. | WU BaoJin ZENG YongMei MAO HuiHua YIN LiJing ZHU Jie YANG WeiWei YIN XiaoShu WU PeiLin ZHANG WeiDong | 2010 | Chinese Science Bulletin2010，55，35： | 0 |
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