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| 1 | Reversing drug resistance of soft tumor-repopulating cells by tumor cell-derived chemotherapeutic microparticles显示文摘颠倒使人重新住入肿瘤的房间(TRC ) 的药抵抗或起源的发展中的新奇途径像房间的癌症房间是迫切临床的需要改进癌症病人的结果。这里,我们显示出用肿瘤颠倒 TRC 的药抵抗的一条创新途径包含反肿瘤药的导出房间的 microparticles (T-MPs ) 。由比区分的癌症房间更可变形的优点, TRC 优先地收起 T-MPs 在进入房间以后释放反肿瘤药,它接着导致 TRC 的死亡。内在的机制包括防碍药流出并且支持这些药的原子入口。我们的调查结果在用有希望的临床的应用程序颠倒 TRC 的药抵抗在 T-MPs 的举起和一条新奇途径的有效性表明肿瘤房间柔软的重要性。 | Jingwei Ma Yi Zhang Ke Tang Huafeng Zhang Xiaonan Yin Yong Li Pingwei Xu Yanling Sun Ruihua Ma Tiantian Ji Junwei Chen Shuang Zhang Tianzhen Zhang Shunqun Luo Yang Jin Xiuli Luo Chengyin Li Hongwei Gong Zhixiong Long Jinzhi Lu Zhuowei Hu Xuetao Cao Ning Wang Xiangliang Yang Bo Huang | 2016 | Cell Research2016，26，6： | 17 |
| 2 | The basic characteristics and spatial patterns of global cultivated land change since the 1980s显示文摘在这份报纸,我们用全球基于向量的陆地使用 / 登陆盖子数据分析了在 1982 和 2011 之间的栽培陆地变化的空间模式。(1 ) 我们的分析证明全部的全球栽培陆地区域增加了 528.768 吗?? | YAO Ziyan ZHANG Lijuan TANG Shihao LI Xiaxiang HAO Tiantian | 2017 | Journal of Geographical Sciences2017，27，7： | 17 |
| 3 | Offline two-dimensional liquid chromatography coupled with ion mobility-quadrupole time-of-flight mass spectrometry enabling fourdimensional separation and characterization of the multicomponents from white ginseng and red ginseng显示文摘Inherent complexity of plant metabolites necessitates the use of multi-dimensional information to accomplish comprehensive profiling and confirmative identification.A dimension-enhanced strategy,by offline two-dimensional liquid chromatography/ion mobility-quadrupole time-of-flight mass spectrometry(2 D-LC/IM-QTOF-MS)enabling four-dimensional separations(2 D-LC,IM,and MS),is proposed.In combination with in-house database-driven automated peak annotation,this strategy was utilized to characterize ginsenosides simultaneously from white ginseng(WG)and red ginseng(RG).An offline 2 DLC system configuring an Xbridge Amide column and an HSS T3 column showed orthogonality 0.76 in the resolution of ginsenosides.Ginsenoside analysis was performed by data-independent high-definition MSE(HDMSE)in the negative ESI mode on a Vion?IMS-QTOF hybrid high-resolution mass spectrometer,which could better resolve ginsenosides than MSEand directly give the CCS information.An in-house ginsenoside database recording 504 known ginsenosides and 58 reference compounds,was established to assist the identification of ginsenosides.Streamlined workflows,by applying UNIFI?to automatedly annotate the HDMSEdata,were proposed.We could separate and characterize 323 ginsenosides(including 286 from WG and 306 from RG),and 125 thereof may have not been isolated from the Panax genus.The established 2 D-LC/IM-QTOF-HDMSEapproach could also act as a magnifier to probe differentiated components between WG and RG.Compared with conventional approaches,this dimensionenhanced strategy could better resolve coeluting herbal components and more efficiently,more reliably identify the multicomponents,which,we believe,offers more possibilities for the systematic exposure and confirmative identification of plant metabolites. | Tiantian Zuo Chunxia Zhang Weiwei Li Hongda Wang Ying Hu Wenzhi Yang Li Jia Xiaoyan Wang Xiumei Gao Dean Guo | 2020 | Journal of Pharmaceutical Analysis2020，10，6： | 9 |
| 4 | Clinical characteristics and survival of 5283 esophageal cancer patients: A multicenter study from eighteen hospitals across six regions in China显示文摘Objective:This study aimed to investigate the potential determining epidemiological and clinical risk factors affecting the survival of esophageal cancer(EC)patients across multiple hospitals in China.Methods:This was a multicenter study comprising of newly diagnosed EC cases from Beijing,Hebei,Henan,Hubei,Zhejiang,and Guangdong Province of China.Their baseline characteristics and treatment methods data were collected from their medical records.The EpiData software was used for data quality control.The Kaplan-Meier method was used to estimate their overall survival(OS),and the Cox’s proportional hazard regression model was used to estimate hazard ratios(HR)and 95%confidence interval(CI).Results:The 3-and 5-year OS rates of the 5283 investigated EC patients were 49.98%and 39.07%,respectively.Their median survival was 36.00 months.The median survival time of females was longer than that of males(females vs.males:45.00 vs.33.00,P<0.001).The 5-year OS rate of patients who never-smoked was higher than that of smokers(never-smokers vs smokers:40.73%vs.37.84%,P=0.001).There was no significant difference in the 5-year OS rate between drinkers and never-drinkers(drinkers vs never-drinkers:34.22%vs.29.65%,P=0.330).In multivariate analysis,pathological stage(stage II:HR=1.80,95%CI=1.40-2.31;stage III:HR=2.62,95%CI=2.06-3.34;stage IV:HR=3.90,95%CI=2.98-5.09),poor differentiation/undifferentiated(HR=1.34,95%CI=1.11-1.63),not married status(HR=2.45,95%CI=1.49-4.04),production and service personnel(HR=1.36,95%CI=1.01-1.83)and farming/fishing(HR=1.40,95%CI=1.12-1.76)were independent prognostic risk factors for poor EC survival.Tumors in the thoracic or abdominal part of the esophagus,female and family history of any cancer were independent factors predictive of a good EC OS.Conclusion:Gender,marital status,occupation,family history of any cancer,tumor topographical site,differentiation status,and pathological stage were associated with the survival rate of EC.This study reveals important clinical characteristics of esophageal cancer patients in China and provides helpful information for their clinical management and surveillance. | Yutong He Di Liang Lingbin Du Tiantian Guo Yanyu Liu Xibin Sun Ning Wang Min Zhang Kuangrong Wei Baoen Shan Wanqing Chen | 2020 | Cancer Communications2020，40，10： | 8 |
| 5 | Enhanced dewaterability of waste activated sludge by UV assisted ZVI-PDS oxidation显示文摘Ultraviolet(UV)assisted zero-valent iron(ZVI)-activated sodium persulfate(PDS)oxidation(UV-ZVI-PDS)was used to treat waste activated sludge(WAS)in this study.The dewaterability performance and mechanism of WAS dewatering were analyzed.The results showed that UV-ZVI-PDS can obtain better sludge dewatering performance in a wide pH range(2.0-8.0).When the molar ratio of ZVI/PDS was 0.6,UV was 254nm,PDS dosage was 200 mg/g TS(total solid),pH was 6.54,reaction time was 20 min,the CST(capillary suction time)and SRF(specific resistance to filtration)were decreased by 64.0%and 78.2%,respectively.The molar ratio of ZVI/PDS used in this paper is much lower than that of literatures,and the contents of total Fe and Fe^(2+) in sludge supernatant remained at a low level,as 3.7 mg/L and 0.0 mg/L.The analysis of extracellular polymeric substances(EPS),scanning electron microscope(SEM)and particle size distribution showed that the EPS could be effectively destroyed by UV-ZVI-PDS,the sludge flocs broken down into smaller particles,cracks and holes appeared,and then the bound water was released.At the same time,the highly hydrophilic tightly bound-EPS(TB-EPS)were converted into loosely bound EPS(LB-EPS)and soluble EPS(S-EPS).During sludge pretreated by UV-ZVI-PDS,positively charged ions,such as Fe^(2+),Fe^(3+) and H^(+),produced in the reaction system could reduce the electronegativity of sludge surface,promote sludge particles aggregation,and then enhanced the sludge dewaterability. | Yanping Zhang Tiantian Li Jiayu Tian Huichun Zhang Fen Li Jiahua Pei | 2022 | Journal of Environmental Sciences2022，34，3： | 7 |
| 6 | Perovskite light-emitting/detecting bifunctional fibres for wearable LiFi communication显示文摘Light fidelity(LiFi),which is emerging as a compelling technology paradigm shifting the common means of highcapacity wireless communication technologies,requires wearable and full-duplex compact design because of its great significance in smart wearables as well as the‘Internet of Things’.However,the construction of the key component of wearable full-duplex LiFi,light-emitting/detecting bifunctional fibres,is still challenging because of the conflicting process between carrier separation and recombination,as well as the highly dynamic film-forming process.Here,we demonstrate light-emitting/detecting bifunctional fibres enabled by perovskite QDs with hybrid components.The hybrid perovskite inks endow fibres with super-smooth QD films.This,combined with the small exciton binding energy and high carrier mobility of perovskite QDs,enables successful integration of electroluminescence and photodetection into monofilaments.The bifunctional fibres possess the narrowest electroluminescence full width at half maximum of ~19 nm and,more importantly,the capability for simultaneously transmitting and receiving information.The successful fabrication of narrow emission full-duplex LiFi fibres paves the way for the fabrication and integration of low crosstalk interoperable smart wearables. | Qingsong Shan Changting Wei Yan Jiang Jizhong Song Yousheng Zou Leimeng Xu Tao Fang Tiantian Wang Yuhui Dong Jiaxin Liu Boning Han Fengjuan Zhang Jiawei Chen Yongjin Wang Haibo Zeng | 2020 | Light(Science & Applications)2020，9，1： | 7 |
| 7 | Construction of plasmid vector pAFP-HSVtk-IRES2-EGFP and its effect on the cytotoxicity of ganciclovir to hepatocellular carcinoma显示文摘 | Lai Zhiyong Qin Qin Yu Baofeng Xie Jun Gao Ranpeng Zhang Tiantian Li Chunfeng Niu Kai Xu Jun | 2014 | Chinese Medical Journal2014，，12： | 6 |
| 8 | Ecological indicators showing the succession of macrofauna communities in Sonneratia apetala artificial mangrove wetlands on Qi'ao Island at Zhuhai, South China显示文摘The Sonneratia apetala artificial mangroves in the intertidal zone of Da Wei Bay at Qi'ao Island of Zhuhai, South China were chosen as the macrofauna succession plots while bare tidal flats of the same size were established as control plots in surrounding interference-free areas. Conventional change indicators of community structure, such as biomass and biodiversity, and indicators, such as exergy and specific exergy, which reflect the information change of overall communities, were used to analyze the succession of macrofauna communities in S. apetala artificial mangroves. The similarities and differences in variation tendency of the different ecological indicators and their reflected ecological principles were compared. The results showed that from D-1 to D-1275 after planting S. apetala, the biomass of the macrofauna communities first increased, which was then followed by an increase in the network relationship between the macrofauna communities(analysis of the Pielou evenness index and Shannon-Wiener diversity index). The system information(specific exergy) increased the slowest. Between D-1460 and D-2370 after planting S. apetala, there was a decrease in biomass, network structure, and system information in the succession plots. After the decrease in the system information(the specific exergy), there was a decline in the network relationships(Pielou evenness index and Shannon-Wiener diversity index). Biomass was the last indicator to decrease. The similarities and differences among the different ecological indicators varied during the succession process, which reflected the relativity and differences among the indicators. This study suggested that, although the species diversity index can be an effective indicator of two types of changes(network structure and system information), it was quite clear that species diversity measurement was not suitable for expressing the changes in biomass during the succession process. While exergy and specific exergy can provide useful information about the structural development of communities, they cannot identify the information state of the system. Therefore, when evaluating macrofaunal succession in S. apetala artificial mangrove wetlands, it would be better to apply a number of different ecological indicators, rather than just one single indicator. | TANG Yijie FANG Zhanqiang ZHANG Zaiwang ZHONG Yanting CHEN Kang LIU Benhan FAN Junjie XIONG Tiantian LU Xiaosheng | 2014 | Acta Oceanologica Sinica2014，33，8： | 6 |
| 9 | Development of the National Air Quality Health Index-China,2013−2018显示文摘What is already known about this topic?While the establishment of an air quality health index(AQHI)in some countries yielded positive outcomes in communicating health risks of air pollution,China lagged behind in developing its own AQHI.Several research studies of AQHI were conducted in China,but this scientific research has not yet been applied to standards.What is added by this report?This report introduced the method of calculation of Chinese AQHI to be launched in pilot cities.The index in this report was established on the basis of fully drawing on international experience and considering Chinese characteristics.What are the implications for public health practice?The purpose of this report is to guide unified application of the AQHI throughout China and translate scientific evidence into public services to promote public health.Based on the AQHI construction method in this report,an AQHI real-time computing platform and data transfer interface will be developed.The release of AQHI aims to communicate health risk of air pollution and provide scientific health protective guidance to the general public,accordingly to protect people’s health. | Qinghua Sun Huanhuan Zhu Wanying Shi Yu Zhong Yingjian Zhang Tiantian Li | 2021 | China CDC weekly2021，3，4： | 5 |
| 10 | Clopidogrel improves aspirin response after off-pump coronary artery bypass surgery显示文摘We sought to assess the incidence of aspirin resistance after off-pump coronary artery bypass(OPCAB) surgery,and investigate whether clopidogrel can improve aspirin response and be safely applied early after OPCAB surgery.Sixty patients who underwent standard OPCAB surgery were randomized into two groups.One group(30 patients)received mono-antiplatelet treatment(MAPT) with aspirin 100 mg daily and the other group received dual antiplatelet treatment(DAPT) with aspirin 100 mg daily plus clopidogrel 75 mg daily.Platelet aggregations in response to arachidonic acid(PL_(AA)) and adenosine diphosphate(ADP)(PL_(ADP)) were measured preoperatively and on days 1 to 6,8 and10 after the antiplatelet agents were administered.A PL_(AA) level above 20%was defined as aspirin resistance.Postoperative bleeding and other perioperative variables were also recorded.There were no significant differences between the two groups in baseline characteristics,average number of distal anastomosis,operation time,postoperative bleeding,ventilation time and postoperative hospital stay.However,the incidence of aspirin resistance was significantly lower in the DAPT group than that in the MAPT group on the first and second day after antiplatelet agents were given(62.1%vs.32.1%,34.5%vs.10.7%,respectively,both P < 0.05).There was no significant difference in postoperative complication between the two groups.DAPT with aspirin and clopidogrel can be safely applied to OPCAB patients early after the procedure.Moreover,clopidogrel reduces the incidence of OPCAB-related aspirin resistance. | Xuezhong Wang Xiaoxuan Gong Tiantian Zhu Qiu Zhang Yangyang Zhang Xiaowei Wang Zhijian Yang Chunjian Lia | 2014 | The Journal of Biomedical Research2014，28，2： | 5 |
| 11 | Metabolic characteristics and nutrient utilization in high-feedefficiency pigs selected using different feed conversion ratio models显示文摘An understanding of the nutrient utilization characteristics of pigs with different feed efficiencies(FEs) will help us to develop new strategies to reduce the costs of pig production.In this study,we selected pigs with a range of FEs according to two feed conversion ratio models: the feed intake(FI) model,where pigs had the same average daily gains(ADGs) but different FIs,and the ADG model,where pigs had the same FIs but different ADGs.High-FE pigs had a higher abundance of short chain fatty acid(SCFA)-producing bacteria(Lachnospiraceae,Clostridiaceae1,and Coriobacteriaceae) in their caecum in the FI model,and low-FE pigs had a higher abundance of two families(BacteroidalesS247group and Peptococcaceae) and two genera(Anaerotruncus and CandidatusSoleaferrea) in both models.By contrast,high-FE pigs had more goblet cells and higher m RNA expression of insulin-like growth factor 1(IGF-1) in the FI model,and higher mRNA expression of occludin but lower expressions of adenosine monophosphate-activated protein kinase(AMPK)-α2 and peroxisome proliferator-activated receptor gamma coactivator 1 alpha(PGC1α) in the ADG model.These findings suggest that the presence of SCFA-producing bacteria in the caecum and increased muscular growth may contribute to the high FE of low-FI pigs,while improved intestinal functions and decreased mitochondrial activity in the skeletal muscle are related to the high FE of high-ADG pigs. | Beibei He Tiantian Li Wei Wang Hang Gao Yu Bai Shuai Zhang Jianjun Zang Defa Li Junjun Wang | 2019 | Science China(Life Sciences)2019，62，7： | 5 |
| 12 | The absorption kinetics of Antarctic krill oil phospholipid liposome in blood and the digestive tract of healthy mice by single gavage显示文摘Antarctic krill(Euphausia superba)oil has been gaining increasing attention due to its nutritional and functional potentials.Krill oil usually contains a high concentration(about 50%)of phospholipids(AKOP)rich in DHA and EPA accompanied with 30%–40%triacylglycerols.Phospholipids can be made into liposomes without emulsifiers due to its amphiphilic characteristics.However,the absorption kinetics of AKOP liposome in vivo is not clear,which restrict the molecular mechanism analysis related to its distinct bioactivities.The lipid analysis in serum,small intestinal content and wall was carried out after oral administration of AKOP liposome to illustrate its absorption kinetics in blood and the digestive tract of healthy mice by single gavage.The major type of the obtained AKOP was phosphatidylcholine,and the total contents of the DHA and EPA were 29.31%.AKOP liposome was almost completely digested in the small intestine in 1 h and the hydrolysis products could be quickly absorbed by intestinal enterocytes.The DHA in serum peaked at 2 h after administration of AKOP liposome.AKOP liposome could be quickly digested and absorbed in vivo.The obtained results might provide a scientific basis for the molecular mechanism analysis related to distinct bioactivities of Antarctic krill oil phospholipid. | Lin Li Chengcheng Wang Shan Jiang Rong Li Tiantian Zhang Changhu Xue Teruyoshi Yanagita Xiaoming Jiang Yuming Wang | 2020 | Food Science and Human Wellness2020，9，1： | 4 |
| 13 | Effect of Sini San Freeze-dried powder on sleep-waking cycle in insomnia rats显示文摘OBJECTIVE: To investigate the effects of the Sini San at different doses on each sleeping state[slow-wave sleep 1(SWS1), slow-wave sleep 2(SWS2), rapid-eye-movement(REM), wakefulness(W)] in insomnia rats and to identify its mode of ac-tion for improving sleep.METHODS: The insomnia rats were randomly divided into a high-, medium- or low-dose group of Sini San(equal to crude drug 8.8, 4.4, or 2.2 g/kg, respectively) for seven consecutive days.RESULTS: Compared with pre-administration,SWS2 was significantly increased after administration of the low dose. Compared with pre-administration, W was significantly decreased and SWS1,SWS2, and the total sleeping time(TST) were markedly increased after administration of the medium dose. Compared with pre-administration, W was significantly decreased and SWS1, SWS2, rapid-eye-movement sleep, and TST were significantly longer after administration of the high dose. The effects of Sini San on sleep-wake cycle are dose-dependent.CONCLUSION: The results suggest that Sini San extends SWS1 and SWS2, which increases the total sleeping time. | Xingke Yan Zeguo Zhang Fuju Xu Yuefeng Li Tiantian Zhu Chongbing Ma Anguo Liu | 2014 | Journal of Traditional Chinese Medicine2014，34，5： | 4 |
| 14 | Flame-retardant quasi-solid polymer electrolyte enabling sodium metal batteries with highly safe characteristic and superior cycling stability显示文摘Con ventio nal liquid electrolytes based sodium metal batteries suffer from severe safety hazards owing to electrolyte leakage,in flammability and dendritic sodium deposit!on.Herein,we report a flame-retardant quasi-solid polymer electrolyte with poly(methyl vinyl ether-alt-maleic an hydride)(P(MVE-alt-MA))as host,bacterial cellulose(BC)as reinforceme nt,and triethyl phosphate/vinyle ne carb on ate/sodium perchlorate(TEP/VC/NaClO4)as plasticizer for highly safe sodium metal batteries.The as-obtained quasi-solid polymer electrolyte exhibits superior flame retardancy(self-extinguish within 1 s),complete non-leakage property and wide electrochemical windows(4.4 V).More importantly,Na3V2(PO4)3/Na metal batteries using such polymer electrolyte delivers superior I on g-term cycli ng stability(84.4%capacity rete ntion after 1000 cycles)which is significantly better than that(only 2%after 240 cycles)of liquid electrolyte.In addition,this flame-retardant quasi-solid polymer electrolyte provides favorable cycle performance(80.2%capacity retention after 70 cycles at 50°C and 84.8%capacity retention after 50 cycles at-10°C)for Na3V2(PO4)3/Na metal batteries.And this battery also displayed a normal charge/discharge property even at-15°C.These fascinating cycle properties are mainly ascribed to the effective pro怕ctive layers formed on Na3V2(PC>4)3 cathode and sodium metal ano de.More thorough in vestigati on elucidates that such flame-retardant quasi-solid polymer electrolyte plays a multif unctional role in the adva need sodium metal batteries:(1)being in volved in the formatio n of a favorable cathode electrolyte in terface(CEI)to inhibit the dissolutio n of van adium and maintai n the structure integrity of the Na3V2(PO4)3;(2)participati ng in building a stable solid electrolyte in terface(SEI)to suppress the growth of Na dendrites;(3)integrating flame-retardanee into polymer sodium batteries to enhance flame-resistanee,eliminate electrolyte leakage,and thus improve safety of sodium batteries.Based on these results,we further assembled Na3V2(PO4)3/MoS2 pouch cell which can withsta nd harsh conditions(be nded or cut off a corn er),confirming the obtai ned polymer electrolyte with superior non-leakage property.In all,these outstanding characteristics would endow this flame-retardant quasi-solid polymer electrolyte a very promising can didate for highly-safe sodium metal batteries. | Jinfeng Yang Min Zhang Zheng Chen Xiaofan Du Suqi Huang Ben Tang Tiantian Dong Han Wu Zhe Yu Jianjun Zhang Guanglei Cui | 2019 | Nano Research2019，12，9： | 4 |
| 15 | Study on Local Resistance of non-Newtonian Power Law Fluid in Elbow Pipes显示文摘This paper focuses on the flow characteristic and local resistance of non-Newtonian power law fluid in a curved90° bend pipe with circular cross-sections,which are widely used in industrial applications.By employing numerical simulation and theoretical analysis the properties of the flow and local resistance of power law fluid under different working conditions are obtained.To explore the change rule the experiment is carried out by changing the Reynolds number,the wall roughness and different diameter ratio of elbow pipe.The variation of the local resistance coefficient with the Reynolds number,the diameter ratio and the wall roughness is presented comprehensively in the paper.The results show that the local resistance force coefficient hardly changes with Reynolds number of the power law fluid;the wall roughness has a significant impact on the local resistance coefficient.As the pipe wall roughness increasing,the coefficient of local resistance force will increase.The main reason of the influence of the roughness on the local resistance coefficient is the increase of the eddy current region in the power law fluid flow,which increases the kinetic energy dissipation of the main flow.This paper provides theoretical and numerical methods to understand the local resistance property of non-Newtonian power law fluid in elbow pipes. | ZHANG Hao XU Tiantian ZHANG Xinxin WANG Yuxiang WANG Yuancheng LIU Xueting | 2016 | Journal of Thermal Science2016，25，3： | 4 |
| 16 | Symptom network topological features predict the effectiveness of herbal treatment for pediatric cough显示文摘Pediatric cough is a heterogeneous condition in terms of symptoms and the underlying disease mechanisms.Symptom phenotypes hold complicated interactions between each other to form an intricate network structure.This study aims to investigate whether the network structure of pediatric cough symptoms is associated with the prognosis and outcome of patients.A total of 384 cases were derived from the electronic medical records of a highly experienced traditional Chinese medicine (TCM) physician.The data were divided into two groups according to the therapeutic effect,namely,an invalid group (group A with 40 cases of poor efficacy) and a valid group (group B with 344 cases of good efficacy).Several well-established analysis methods,namely,statistical test,correlation analysis,and complex network analysis,were used to analyze the data.This study reports that symptom networks of patients with pediatric cough are related to the effectiveness of treatment: a dense network of symptoms is associated with great difficulty in treatment.Interventions with the most different symptoms in the symptom network may have improved therapeutic effects. | Mengxue Huang Jingjing Wang Runshun Zhang Zhuying Ni Xiaoying Liu Wenwen Liu Weilian Kong Yao Chen Tiantian Huang Guihua Li Dan Wei Jianzhong Liu Xuezhong Zhou | 2020 | Frontiers of Medicine2020，14，3： | 4 |
| 17 | Protective Effect of Bacillus subtilis Peptidoglycan (PG) on β-conglycinin-induced Intestinal Epithelial Cells Damage of Juvenile Carp (Cyprinus carpio)显示文摘[Objective] The paper was to investigate the protective effects of different concentrations of Bacillus subtilis peptidoglycan(PG) on β-conglycinin-induced inflammatory injury in intestinal epithelial cells of juvenile carp(Cyprinus carpio).[Method] In 24-cell microplates, the intestinal epithelial cells(IECs) of juvenile carp were primarily cultured for 72 h at 26°C and 6% CO2, and then the IECs were randomly divided into6 groups with 4 replicates per group. One of the six groups was set as negative control group, and the other groups were all supplemented with 1.0 mg/mL β-conglycinin in culture medium to establish inflammatory injury. At 24 h post induction, the culture media were changed into B. subtilis PG culture media with the concentrations of 0(positive control group), 0.15, 0.30, 0.45 and 0.60 mg/mL, respectively. The samples were collected to measure the antioxidant and anti-inflammatory indices at 12, 24 and 36 h post culture.[Result]β-conglycinin exposure significantly decreased the activity of ASA, AHR, SOD, CAT, GPx, and increased the PC content and the mRNA expression of inflammatory cytokines(IL-1β, IL-8, TNF-α1,IL-10 and TGF-β). At 12, 24 and 36 h post PG treatment, the activities of ASA, AHR, SOD, CAT, GPx and the content of PC in cells decreased in a dose-dependent manner;the mRNA levels of IL-1β, IL-8 and TNF-α1 were down-regulated and those of IL-10 and TGF-β were up-regulated.[Conclusion] Different concentrations of B. subtilis PG could protect IECs oxidative damage induced by β-conglycinin and improve the antioxidant capacity of IECs. High concentration of PG could improve the anti-inflammatory ability of IECs by inhibiting inflammatory factors and promoting the gene expression of anti-inflammatory cytokines. | Zhang Tiantian Yin Haicheng Huang Wei | 2019 | Animal Husbandry and Feed Science2019，11，2： | 3 |
| 18 | Clinical Predictors of Functional Cure in Children 1–6 Years-old with Chronic Hepatitis B显示文摘Background and Aims:Hepatitis B surface antigen(HBsAg)clearance is significantly more common in children with chronic hepatitis B(CHB)than in adults;however,the possible influencing factors related to HBsAg loss have yet to be found.This study aimed to explore the efficacy of long-term interferon(IFN)αtherapy in treating children with CHB and analyzed the factors influencing functional cure after treatment.Methods:A total of 236 children aged 1–6 years and diagnosed with CHB via liver biopsy were included in the study,all receiving IFNαtreatment(IFNα-2b monotherapy,IFNα-2b followed by lamivudine[LAM]or IFNα-2b combined with LAM)and followed up for 144 weeks.A comprehensive analysis was conducted on clinical data,including biochemical items,serum markers of hepatitis B virus(HBV)and immunological indexes,and logistic regression analysis was used to screen the influencing factors related to HBsAg loss.Results:The cumulative loss rates of HBsAg were 79.5%,62.1%and 42.1%at 144 weeks after the start of treatment in the 1–3 years-old group,3–5 years-old group and 5–7 years-old group,respectively(p<0.05).IFNα-2b combined with LAM treatment displayed the highest HBsAg loss rates compared with monotherapy and sequential treatment(p=0.011).Younger baseline age and lower HBsAg levels were independent factors for the prediction of HBsAg loss(p<0.05).The baseline PreS1 and hepatitis B core antibody levels in the HBsAg loss group were lower than those in the HBsAg non-loss group.In addition,the PreS1 level was positively corelated with the level of HBsAg,HBV DNA and liver inflammation.Conclusions:Long-term treatment with IFNαwas effective in achieving HBsAg loss in CHB children aged 1–6 years-old.Age less than 3 years-old and lower HBsAg levels are independent predictors of functional cure in children with CHB. | Jing Pan Haiyan Wang Tiantian Yao Xuejiao Liao Hao Cheng Suthat Liangpunsakul Yan Wang Min Zhang Zheng Zhang | 2022 | Journal of Clinical and Translational Hepatology2022，10，3： | 3 |
| 19 | Polymer electrolytes for Li-S batteries:Polymeric fundamentals and performance optimization显示文摘Lithium-sulfur(Li-S) batteries have been considered as one of the most promising candidates to traditional lithium ion batteries due to its low cost,high theoretical specific capacity(1675 mAh g^(-1)) and energy density(2600 Wh kg^(-1)) of sulfur.Compared with traditional liquid electrolytes,polymer electrolytes(PEs) are ever-increasingly preferred due to their higher safety,superior compatibility,long cycling stability and so on.Despite some progresses on PEs,however,there remain lots of hurdles to be addressed prior to commercial applications.This review begins with native advantages for PEs to replace LEs,and then proposes the ideal requirements for PEs.Furthermore,a brief development history of typical PEs for Li-S batteries is presented to systematically summarize the recent achievements in Li-S batteries with PEs.Noted that the structure-performance relationships of polymer matrixes for PEs are highlighted.Finally,the challenges and opportunities on the future development of PEs are presented.We hold the view that composite polymer electrolytes in virtue of the high ionic conductivity and the compatible interfacial property will be promising solution for high performance Li-S batteries. | Meifang Jiang Zengqi Zhang Ben Tang Tiantian Dong Hantao Xu Huanri Zhang Xiaolan Lu Guanglei Cui | 2021 | Journal of Energy Chemistry2021，30，7： | 3 |
| 20 | Prodrugs incorporated into nanotechnology-based drug delivery systems for possible improvement in bioavailability of ocular drugs delivery显示文摘Numerous systems have been designed during the past three decades to improve bioavailability of ophthalmic drug delivery,including:ocular prodrugs and nanotechnology-based drug delivery system.The former can improve the efficacy of ocular drug via enhancing corneal penetration of ocular drugs,prolonging their duration of action and/or reducing the systemic side-effects,unfortunately,some characteristics of the pro-drugs,such as poorly aqueous stability,poorly aqueous solubility and severe eye irritation probably,limit their clinical practice and cannot be ignored.As we all know,nanotech-nology for ocular drug delivery can carry poorly soluble drugs,protect the encapsulated molecules from hydrolysis,control the rate of drug delivery and prolong the precorneal retention of drugs.All of these merits may solve the problems in the utilization of ocular prodrugs and increase the bioavailability of ocular drug delivery.By reviewing recent ad-vances of prodrugs and nanostructures in ocular drug delivery,this paper focus specifically on the promising prospects of nanocarriers overcoming the drawbacks of prodrugs for ophthalmic drug delivery by precorneal routes. | Tiantian Ye Kun Yuan Wenji Zhang Shuangshuang Song Fen Chen Xinggang Yang Shujun Wang Jianwei Bi Weisan Pan | 2013 | Asian Journal of Pharmaceutical Sciences2013，8，4： | 3 |
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