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| 1 | Foreign Friends in China Two American 'Peasants' in China显示文摘ForeignFriendsinChinaTwoAmerican"Peasants"inChina￥//TheyhavelivednearlyhalfacenturyinChina,workinghard,alwaysclostothesoil.He... | CHEN WEIYUAN | 1995 | China Today1995，44，2： | 0 |
| 2 | Measurement of electric field distribution along composite insulators by integrated optical electric field sensor显示文摘 | Zeng Rong Zhang Yun Chen Weiyuan | 2008 | IEEE Transactions on Dielectrics and Electrical Insulation2008，15，1： | 1 |
| 3 | Stability and reinforcement analyses of high arch dams by considering deformation effects显示文摘The strict definition and logical description of the concept of structure stability and failure are presented. The criterion of structure stability is developed based on plastic complementary energy and its variation. It is presented that the principle of minimum plastic complementary energy is the combination of structure equilibrium, coordination condition of deformation and constitutive relationship. Based on the above arguments, the deformation reinforcement theory is developed. The structure global stability can be described by the relationship between the global degree of safety of structure and the plastic complementary energy. Correspondingly, the new idea is used in the evaluations of global stability, anchorage force of dam-toe, fracture of dam-heel and treatment of faults of high arch dams in China. The results show that the deformation reinforcement theory provides a uniform and practical theoretical framework and a valuable solution for the analysis of global stability, dam-heel cracking, dam-toe anchorage and reinforcement of faults of high arch dams and their foundations. | Qiang Yang Yaoru Liu Yingru Chen Weiyuan Zhou | 2010 | Journal of Rock Mechanics and Geotechnical Engineering2010，2，4： | 1 |
| 4 | A Compensation Algorithm for Large Element Characterizing the Damage Evolution Process and Its Application to Structure Collisions显示文摘When simulating the process from elastic–plastic deformation,damage to failure in a metal structure collision,it is necessary to use the large shell element due to the calculation efficiency,but this would affect the accuracy of damage evolution simulation.The compensation algorithm adjusting failure strain according to element size is usually used in the damage model to deal with the problem.In this paper,a new nonlinear compensation algorithm between failure strain and element size was proposed,which was incorporated in the damage model GISSMO(Generalized incremental stress state dependent damage model)to characterize ductile fracture.And associated material parameters were calibrated based on tensile experiments of aluminum alloy specimens with notches.Simulation and experimental results show that the new compensation algorithm significantly reduces the dependence of element size compared with the constant failure strain model and the damage model with the linear compensation algorithm.During the axial splitting process of a circular tubular structure,the new compensation algorithm keeps the failure prediction errors low over the stress states ranging from shear to biaxial tension,and achieves the objective prediction of the damage evolution process.This study demonstrates how the compensation algorithm resolves the contradiction between large element size and fracture prediction accuracy,and this facilitates the use of the damage model in ductile fracture prediction for engineering structures. | Wen Liu Lele Zhang Yifan Ru Geng Chen Weiyuan Dou | 2023 | Chinese Journal of Mechanical Engineering2023，36，1： | 0 |
| 5 | Deformation reinforcement theory and its application to high arch dams显示文摘In this paper,the deformation reinforcement theory(DRT) proposed by the authors is elaborated with a new definition of instability that an elasto-plastic structure is not stable if it cannot satisfy simultaneously equilibrium condition,kinematical admissibility and constitutive equations under the prescribed loading.Starting from the definition,a proof is established to the principle of minimum plastic complementary energy for failured structures.It is revealed that the principle of mini-mum plastic complementary energy results in relaxed constitutive equations,especially,yield conditions.It is demonstrated with case studies that many key issues in arch dam design,e.g.,global stability,dam-toe reinforcement,dam-toe cracking,dam-abut-ment reinforcement,can be well solved within the framework of the deformation reinforcement theory.The structural global stability can be described by the curve of the plastic complementary energy vs overloading factor.The unbalanced-forces obtained by elasto-plastic FEM can be used as the basis of analysis of global stability,dam-heel cracking,dam-toe anchorage and reinforcement of faults of high arch dams and their foundations. | YANG Qiang,LIU YaoRu,CHEN YingRu & ZHOU WeiYuan State Key Laboratory of Hydroscience and Hydraulic Engineering,Tsinghua University,Beijing 100084,China | 2008 | Science China(Technological Sciences)2008，51，S2： | 21 |
| 6 | Investigation of change of serum immunosuppressive acidic protein levels in gynecological tumors显示文摘Objective: To study the clinical significance for measuring serum immunosuppressive acidic protein(IAP) levels to diagnose and follow up survey patients with the gynecological tumor.Methods: Serum IAP levels were determined by IAP single radial immunodiffusion test in 235 patients with the gynecological tumor,including 38 cases of benign tumor of ovary,41 cases of malignant tumor of ovary,66 cases of hysteromyoma,34 carcinomas of uterine cervix, 16 endometrial carcinomas,27 cases of chemotherapy,13 cases of recurrence, and the control group was 50 cases health women.Results: Serum IAP level was 889.4±207.8mg/L in malignant ovary tumors,which was significantly higher than that of health women and benign tumors of ovary (P<0.01).In patients with carcinoma of uterine cervix and endometrial carcinoma, their IAP levels were 741.4±212.6mg/L and 763.3±209.4mg/L,which were higher than those of the health women and benign tumor of ovary(P<0.01).After chemotherapy, serum IAP levels of malignant tumor of ovary were decreased;in patients with recurrence of tumor of ovary,IAP levels increased compared with the health women(P<0.01).Incidence of the abnormal value was 100%.Conclusion:Measuring IAP level of the gynecological tumor may be an auxiliary index for monitoring gynecological tumor and identifying benign and malignant tumor. | Zhang Weiyuan,Sun Bo,Chen Mo,Zhao Yanhui. (Department of Obstetrics and Gynecology,Second Teaching Hospital,Jilin University,Changchun 130041) | 2002 | 现代妇产科进展2002，11，6： | 1 |
| 7 | Osteoarthritis:pathogenic signaling pathways and therapeutic targets显示文摘Osteoarthritis(OA)is a chronic degenerative joint disorder that leads to disability and affects more than 500 million population worldwide.OA was believed to be caused by the wearing and tearing of articular cartilage,but it is now more commonly referred to as a chronic whole-joint disorder that is initiated with biochemical and cellular alterations in the synovial joint tissues,which leads to the histological and structural changes of the joint and ends up with the whole tissue dysfunction.Currently,there is no cure for OA,partly due to a lack of comprehensive understanding of the pathological mechanism of the initiation and progression of the disease.Therefore,a better understanding of pathological signaling pathways and key molecules involved in OA pathogenesis is crucial for therapeutic target design and drug development.In this review,we first summarize the epidemiology of OA,including its prevalence,incidence and burdens,and OA risk factors.We then focus on the roles and regulation of the pathological signaling pathways,such as Wnt/β-catenin,NF-κB,focal adhesion,HIFs,TGFβ/ΒΜP and FGF signaling pathways,and key regulators AMPK,mTOR,and RUNX2 in the onset and development of OA.In addition,the roles of factors associated with OA,including MMPs,ADAMTS/ADAMs,and PRG4,are discussed in detail.Finally,we provide updates on the current clinical therapies and clinical trials of biological treatments and drugs for OA.Research advances in basic knowledge of articular cartilage biology and OA pathogenesis will have a significant impact and translational value in developing OA therapeutic strategies. | Qing Yao Xiaohao Wu Chu Tao Weiyuan Gong Mingjue Chen Minghao Qu Yiming Zhong Tailin He Sheng Chen Guozhi Xiao | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 11 |
| 8 | Genetic contribution of foreign germplasm to elite Chinese soybean (Glycine max) cultivars revealed by SSR markers显示文摘Simple sequence repeats (SSR) marker analysis, combined with pedigree analysis, was car- ried out to trace the genetic constitutes of Suinong 14 and Hefeng 25 in assessing the contribution of for- eign germplasm to those elite cultivars. The overall goal is to accumulate information for further effective utilization of foreign germplasm in Chinese soybean breeding programs. SSR clustering results indicated that the genetic base of elite Chinese soybean culti- vars, including Suinong 14 and Hefeng 25, were broadened and enhanced via introduction of Amsoy from the U.S. and Shishengchangye from Japan. The pedigree analysis showed a very high coefficient of parentage between Shishengchangye and Hefeng 25, between Shishengchangye and Suinong 14, and between Amsoy and Suinong 14. The genetic simi- larity between Suinong 14 and Hefeng 25 was 60.58%. Among 20 linkage groups, more genomic regions were transferred from Hefeng 25 to Suinong 14 in linkage group (LG) I, L and C2 than other LGs. Among the unique alleles of foreign parents, five specific loci in Amsoy were transferred to Suinong 14, and three loci from Shishengchangye to Suinong 14. Some SSR loci were proved to be correlated with phenotypes: two loci for seed size introgressed from Shishengchangye to Suinong 14, and one locus forprotein content from Amsoy to Suinong 14. These results indicate that the two foreign parents might have important contributions in the development of Suinong 14 and Hefeng 25. | QIN Jun CHEN Weiyuan GUAN Rongxia JIANG Chengxi LI Yinghui FU Yashu LIU Zhangxiong ZHANG Mengchen CHANG Ruzhen QIU Lijuan | 2006 | Chinese Science Bulletin2006，51，9： | 4 |
| 9 | Recent advances in the development of nanomedicines for the treatment of ischemic stroke显示文摘Ischemic stroke is still a serious threat to human life and health,but there are few therapeutic options available to treat stroke because of limited blood-brain penetration.The development of nanotechnology may overcome some of the problems related to traditional drug development.In this review,we focus on the potential applications of nanotechnology in stroke.First,we will discuss the main molecular pathological mechanisms of ischemic stroke to develop a targeted strategy.Second,considering the important role of the blood-brain barrier in stroke treatment,we also delve mechanisms by which the blood-brain barrier protects the brain,and the reasons why the therapeutics must pass through the blood-brain barrier to achieve efficacy.Lastly,we provide a comprehensive review related to the application of nanomaterials to treat stroke,including liposomes,polymers,metal nanoparticles,carbon nanotubes,graphene,black phosphorus,hydrogels and dendrimers.To conclude,we will summarize the challenges and future prospects of nanomedicine-based stroke treatments. | Xing Tian Taojian Fan Wentian Zhao Ghulam Abbas Bo Han Ke Zhang Nan Li Ning Liu Weiyuan Liang Hao Huang Wen Chen Bing Wang Zhongjian Xie | 2021 | Bioactive Materials2021，6，9： | 4 |
| 10 | Two-Dimensional Borophene:Properties,Fabrication,and Promising Applications显示文摘Monoelemental two-dimensional(2D)materials(Xenes)aroused a tremendous attention in 2D science owing to their unique properties and extensive applications.Borophene,one emerging and typical Xene,has been regarded as a promising agent for energy,sensor,and biomedical applications.However,the production of borophene is still a challenge because bulk boron has rather intricate spatial structures and multiple chemical properties.In this review,we describe its excellent properties including the optical,electronic,metallic,semiconducting,photoacoustic,and photothermal properties.The fabrication methods of borophene are also presented including the bottom-up fabrication and the top-down fabrication.In the end,the challenges of borophene in the latest applications are presented and perspectives are discussed. | Zhongjian Xie Xiangying Meng Xiangnan Li Weiyuan Liang Weichun Huang Keqiang Chen Jianming Chen Chenyang Xing Meng Qiu Bin Zhang Guohui Nie Ni Xie Xiaobing Yan Han Zhang | 2020 | Research2020，，1： | 2 |
| 11 | Kindlin-2 loss in condylar chondrocytes causes spontaneous osteoarthritic lesions in the temporomandibular joint in mice显示文摘The progressive destruction of condylar cartilage is a hallmark of the temporomandibular joint(TMJ) osteoarthritis(OA);however, its mechanism is incompletely understood. Here, we show that Kindlin-2, a key focal adhesion protein, is strongly detected in cells of mandibular condylar cartilage in mice. We find that genetic ablation of Kindlin-2 in aggrecan-expressing condylar chondrocytes induces multiple spontaneous osteoarthritic lesions, including progressive cartilage loss and deformation, surface fissures, and ectopic cartilage and bone formation in TMJ. Kindlin-2 loss significantly downregulates the expression of aggrecan, Col2a1 and Proteoglycan 4(Prg4), all anabolic extracellular matrix proteins, and promotes catabolic metabolism in TMJ cartilage by inducing expression of Runx2and Mmp13 in condylar chondrocytes. Kindlin-2 loss decreases TMJ chondrocyte proliferation in condylar cartilages. Furthermore,Kindlin-2 loss promotes the release of cytochrome c as well as caspase 3 activation, and accelerates chondrocyte apoptosis in vitro and TMJ. Collectively, these findings reveal a crucial role of Kindlin-2 in condylar chondrocytes to maintain TMJ homeostasis. | Yumei Lai Wei Zheng Minghao Qu Christopher C.Xiao Sheng Chen Qing Yao Weiyuan Gong Chu Tao Qinnan Yan Peijun Zhang Xiaohao Wu Guozhi Xiao | 2022 | International Journal of Oral Science2022，14，3： | 0 |
| 12 | Lineage tracing reveals the origin of Nestin-positive cells are heterogeneous and rarely from ependymal cells after spinal cord injury显示文摘Nestin is expressed extensively in neural stem/progenitor cells during neural development, but its expression is mainly restricted to the ependymal cells in the adult spinal cord. After spinal cord injury(SCI), Nestin expression is reactivated and Nestinpositive(Nestin;) cells aggregate at the injury site. However, the derivation of Nestin;cells is not clearly defined. Here, we found that Nestin expression was substantially increased in the lesion edge and lesion core after SCI. Using a tamoxifen inducible CreER(T2)-loxP system, we verified that ependymal cells contribute few Nestin;cells either to the lesion core or the lesion edge after SCI. In the lesion edge, GFAP+astrocytes were the main cell type that expressed Nestin;they then formed an astrocyte scar.In the lesion core, Nestin;cells expressed αSMA or Desmin, indicating that they might be derived from pericytes. Our results reveal that Nestin;cells in the lesion core and edge came from various cell types and rarely from ependymal cells after complete transected SCI, which may provide new insights into SCI repair. | Xiaoyu Xue Muya Shu Zhifeng Xiao Yannan Zhao Xing Li Haipeng Zhang Yongheng Fan Xianming Wu Bing Chen Bai Xu Yaming Yang Weiyuan Liu Sumei Liu Jianwu Dai | 2022 | Science China(Life Sciences)2022，65，4： | 2 |
| 13 | Transplantation of neural stem progenitor cells from different sources for severe spinal cord injury repair in rat显示文摘Neural stem progenitor cell(NSPC)transplantation has been regarded as a promising therapeutic method for spinal cord injury(SCI)repair.However,different NSPCs may have different therapeutic effects,and it is therefore important to identify the optimal NSPC type.In our study,we compared the transcriptomes of human fetal brain-derived NSPCs(BNSPCs),spinal cord-derived NSPCs(SCNSPCs)and H9 embryonic stem-cell derived NSPCs(H9-NSPCs)in vitro and subsequently we transplanted each NSPC type on a collagen scaffold into a T8-9 complete SCI rat model in vivo.In vitro data showed that SCNSPCs had more highly expressed genes involved in nerve-related functions than the other two cell types.In vivo,compared with BNSPCs and H9-NSPCs,SCNSPCs exhibited the best therapeutic effects;in fact,SCNSPCs facilitated electrophysiological and hindlimb functional recovery.This study demonstrates that SCNSPCs may be an appropriate candidate cell type for SCI repair,which is of great clinical significance. | Bai Xu Man Yin Yaming Yang Yunlong Zou Wenbin Liu Lianyong Qiao Jixiang Zhang Zhan Wang Yayu Wu He Shen Minghan Sun Weiyuan Liu Weiwei Xue Yongheng Fan Qi Zhang Bing Chen Xianming Wu Ya Shi Falong Lu Yannan Zhao Zhifeng Xiao Jianwu Dai | 2023 | Bioactive Materials2023，，5： | 0 |
| 14 | Engineered human spinal cord-like tissues with dorsal and ventral neuronal progenitors for spinal cord injury repair in rats and monkeys显示文摘Transplanting human neural progenitor cells is a promising method of replenishing the lost neurons after spinal cord injury (SCI), but differentiating neural progenitor cells into the diverse types of mature functional spinal cord neurons in vivo is challenging. In this study, engineered human embryonic spinal cord-like tissues with dorsal and ventral neuronal characters (DV-SC) were generated by inducing human neural progenitor cells (hscNPCs) to differentiate into various types of dorsal and ventral neuronal cells on collagen scaffold in vitro. Transplantation of DV-SC into complete SCI models in rats and monkeys showed better therapeutic effects than undifferentiated hscNPCs, including pronounced cell survival and maturation. DV-SC formed a targeted connection with the host’s ascending and descending axons, partially restored interrupted neural circuits, and improved motor evoked potentials and the hindlimb function of animals with SCI. This suggests that the transplantation of pre-differentiated hscNPCs with spinal cord dorsal and ventral neuronal characteristics could be a promising strategy for SCI repair. | Bai Xu Dingyang Liu Weiyuan Liu Ge Long Wenbin Liu Yayu Wu Xinghui He Yeyu Shen Peipei Jiang Man Yin Yongheng Fan He Shen Liyang Shi Qi Zhang Weiwei Xue Chen Jin Zhenni Chen Bing Chen Jiayin Li Yali Hu Xing Li Zhifeng Xiao Yannan Zhao Jianwu Dai | 2023 | Bioactive Materials2023，，9： | 0 |
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