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| 1 | Plant-derived phosphocholine facilitates cellular uptake of anti-pulmonary fibrotic HJT-sRNA-m7显示文摘Pulmonary fibrosis, a progressive chronic disease with a high mortality rate, has limited treatment options. Currently, lung transplantation remains the only effective treatment. Here we report that a small RNA, HJT-sRNA-m7, from a Chinese herbal medicine Hong Jing Tian(HJT, RHODIOHAE CRENULATAE RADIX ET RHIZOMA, Rhodiola crenulata) can effectively reduce the expressions of fibrotic hallmark genes and proteins both in alveolar in vitro and in mouse lung tissues in vivo. We also discovered over one hundred oil-soluble chemicals from HJT decoctions, most of which are found in lipid extracts from other Chinese herbals decoctions, including Pu Gong Ying(PGY, TARAXACI HERBA, Taraxacum mongolicum), Chuan Xin Lian(CXL, changed to 'ANDROGRAPHIS HERBA, Andrographis paniculata'), and Jin Yin Hua(JYH, lonicera japonica or Honeysuckle). We identified the active component in these decoctions as two forms of phosphocholines, PC(18:0/18:2) and PC(16:0/18:2). These PCs potentially could form liposomes with small RNAs to enter human alveolar and gastric cells. Our experimental results suggest an unprecendent lipid complex route through which botanic small RNA can enter human bodies.Our results provide an innovative treatment strategy for oral delivery of siRNAs as therapeutic medication. | Jianchao Du Zhu Liang Jiantao Xu Yan Zhao Xiaoyun Li Yanli Zhang DANDan Zhao Ruxuan Chen Yang Liu Trupti Joshi Jiahui Chang Zhiqing Wang Yanxu Zhang Jindong Zhu Qiang Liu Dong Xu Chengyu Jiang | 2019 | Science China(Life Sciences)2019，62，3： | 21 |
| 2 | Human carboxylesterases:a comprehensive review显示文摘Mammalian carboxylesterases(CEs) are key enzymes from the serine hydrolase superfamily.In the human body, two predominant carboxylesterases(CES1 and CES2) have been identified and extensively studied over the past decade. These two enzymes play crucial roles in the metabolism of a wide variety of endogenous esters, ester-containing drugs and environmental toxicants. The key roles of CES in both human health and xenobiotic metabolism arouse great interest in the discovery of potent CES modulators to regulate endobiotic metabolism or to improve the efficacy of ester drugs. This review covers the structural and catalytic features of CES, tissue distributions, biological functions, genetic polymorphisms, substrate specificities and inhibitor properties of CES1 and CES2, as well as the significance and recent progress on the discovery of CES modulators. The information presented here will help pharmacologists explore the relevance of CES to human diseases or to assign the contribution of certain CES in xenobiotic metabolism. It will also facilitate medicinal chemistry efforts to design prodrugs activated by a given CES isoform, or to develop potent and selective modulators of CES for potential biomedical applications. | Dandan Wang Liwei Zou Qiang Jin Jie Hou Guangbo Ge Ling Yang | 2018 | Acta Pharmaceutica Sinica B2018，8，5： | 14 |
| 3 | Hydrographic field investigations in the Northern South China Sea by open cruises during 2004-2013显示文摘 | Lili Zeng Qiang Wang Qiang Xie Ping Shi Lei Yang Yeqiang Shu Ju Chen Dandan Sui Yunkai He Rongyu Chen Dongxiao Wang | 2015 | Science Bulletin2015，60，6： | 10 |
| 4 | Progress of regional oceanography study associated with western boundary current in the South China Sea显示文摘Recent progress of physical oceanography in the South China Sea (SCS) associated with the western boundary current (WBC) and eddies is reviewed in this paper. It includes Argo observations of the WBC, eddy detection in the WBC based on satellite images, cross-continental shelf exchange in the WBC, eddy-current interaction, interannual variability of the WBC, air-sea interaction, the SCS throughflow (SCSTF), among others. The WBC in the SCS is strong, and its structure, variability and dynamic processes on seasonal and interannual time scales are yet to be fully understood. In this paper, we summarize progresses on the variability of the WBC, eddy-current interaction, air-sea interaction, and the SCSTF achieved in the past few years. Firstly, using the drifting buoy observations, we point out that the WBC becomes stronger and narrower after it reaches the central Vietnam coast. The possible mechanisms influencing the ocean circulation in the northern SCS are discussed, and the dynamic mechanisms that induce the countercurrent in the region of northern branch of WBC in winter are also studied quantitatively using momentum balance. The geostropic component of the WBC was diagnosed using the ship observation along 18°N, and we found that the WBC changed significantly on interannual time scale. Secondly, using the ship observations, two anti-cyclonic eddies in the winter of 2003/2004 in the northern SCS, and three anti-cyclonic eddies in the summer of 2007 along 18°N were studied. The results show that the two anti-cyclonic eddies can propagate southwestward along the continental shelf at the speed of first Rossby wave (~0.1 ms-1 ) in winter, and the interaction between the three anti-cyclonic eddies in summer and the WBC in the SCS is preliminarily revealed. Eddies on the continental shelf of northern SCS propagated southeastward with a maximum speed of 0.09 ms-1 , and those to the east of Vietnam coast had the largest kinetic energy, both of which imply strong interaction between eddy activity and WBC in the SCS. Thirdly, strong intraseasonal variability (ISV) of sea surface temperature (SST) near the WBC regions was found, and the ISV signal of SST in winter weakens the ISV signal of latent heat flux by 20%. Fourthly, the long-term change of SCSTF volume transport and its connection with the ocean circulation in the Pacific were discussed. | WANG DongXiao LIU QinYan XIE Qiang HE ZhiGang ZHUANG Wei SHU YeQiang XIAO XianJun HONG Bo WU XiangYu SUI DanDan | 2013 | Chinese Science Bulletin2013，58，11： | 10 |
| 5 | CD4^(+)CD25^(+)but not CD4^(+)Foxp3^(+) T cells as a regulatory subset in primary biliary cirrhosis显示文摘Increasing evidence indicates a role for regulatory T cells(Tregs)in the immune response and in autoimmune diseases,but the role of Tregs and cytokines in autoimmune hepatic diseases remains largely unclear and controversial,especially in patients with primary biliary cirrhosis(PBC).This study was undertaken to investigate Tregs and different cytokines in the liver and peripheral blood of PBC patients.We found that these patients demonstrated a reduction of CD4^(+)CD25^(+) T cells but elevated CD4^(+)Foxp3^(+) T cells in peripheral blood mononuclear cells(PBMCs)and CD41 T cells.The percentage of CD4^(+)CD25^(+) T cells in PBMCs was negatively correlated with elevated plasma interferon(IFN)-c levels.A liver-specific analysis showed that the frequency of Foxp31 Tregs,transforming growth factor(TGF)-b1 and IFN-c were increased in PBC patients.Our findings suggest that an imbalance between CD4^(+)CD25^(+) Tregs and cytotoxic cytokines plays a crucial role in the pathogenesis of PBC while the role of Foxp3 needs further investigation. | Dandan Wang Huayong Zhang Jun Liang Zhifeng Gu Qiang Zhou Xiangshan Fan Yayi Hou Lingyun Sun | 2010 | Cellular & Molecular Immunology2010，7，6： | 9 |
| 6 | Identification of an endogenous glutamatergic transmitter system controlling excitability and conductivity of atrial cardiomyocytes显示文摘As an excitatory transmitter system,the glutamatergic transmitter system controls excitability and conductivity of neurons.Since both cardiomyocytes and neurons are excitable cells,we hypothesized that cardiomyocytes may also be regulated by a similar system. | Duanyang Xie Ke Xiong Xuling Su Guanghua Wang Qiang Ji Qicheng Zou Lingling Wang Yi Liu Dandan Liang Jinfeng Xue Luxin Wang Xueting Gao Xingdong Gu Hongyu Liu r Xiaoyu He Li Li Jian Yang Youming Lu Luying Peng Yi-Han Chen | 2021 | Cell Research2021，31，9： | 5 |
| 7 | Preparation of Highly Crystalline Microcrystalline Cellulose by Hydrolysis of Cellulose with Phosphotungstic Acid显示文摘Phosphotungstic acid(H_3PW_(12)O_(40), HPW), a kind of solid acid, is widely used for hydrolyzing cellulose to prepare microcrystalline cellulose(MCC). MCC is usually used in food, synthetic leather, chemical and pharmaceutical industries. The use of response surface methodology(RSM)can help avoid the random error caused by single factor experimental design,reduce test times and cost, and improve quality. The RSM was used in this study to determine the following optimal process conditions: H^+ molar quantity, 31 mmol/L; reaction temperature, 93℃; reaction time, 2 h; and solid to liquid ratio, 1∶38. Under these conditions, the crystallinity of MCC was77.4%. Thus, the use of RSM allows the preparation of MCC with higher performance and increased crystallinity. | Jing Wang JinBao Li MeiYun Zhang ShunXi Song DanDan Qiang | 2018 | Paper And Biomaterials2018，3，1： | 5 |
| 8 | Targeting the PI3K/Akt/mTOR signaling pathway by pterostilbene attenuates mantle cell lymphoma progression显示文摘 | Dandan Yu Yong Zhang Gege Chen Yongsheng Xie Zhijian Xu Shuaikang Chang Liangning Hu Bo Li Wenxuan Bu Yingcong Wang Wenqin Xiao Xi Sun Gaomei Chang Lu Gao Sujing Qiang Xiaosong Wu Weiliang Zhu Jumei Shi | 2018 | Acta Biochimica et Biophysica Sinica2018，50，8： | 4 |
| 9 | Adenosine monophosphate-activated protein kinase attenuates cardiomyocyte hypertrophy through regulation of FOXO3a/MAFbx signaling pathway显示文摘心肌质量的控制被认为被蛋白质合成和降级的动态平衡决定。最近的研究表明了表明小径戏的那萎缩相关的 forkhead 盒子 O 3a (FOXO3a )/muscle 萎缩 F 盒子(MAFbx ) 在解朊作用的调整的一个中央角色并且在 cardiomyocyte 肥大上施加禁止的效果。在这研究,我们测试了假设激活 monophosphate 的蛋白质 kinase (AMPK ) 激活稀释的那腺苷由调整表明小径和它的下游的蛋白质降级的 FOXO3a/MAFbx 的 cardiomyocyte 肥大。结果证明有 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR ) 的 AMPK 的激活稀释了血管收缩素 II (Ang II ) 导致的 cardiomyocyte 肥大。AICAR 的 antihypertrophic 效果被 AMPK 禁止者混合物 C 弄钝。另外, AMPK 戏剧性地增加了抄写因素 FOXO3a 的活动,起来调整它的下游的 ubiquitin ligase MAFbx 的表示,和提高的 cardiomyocyte 解朊作用。同时,在 MAFbx 是由有 MAFbx-siRNA 的 cardiomyocytes 的 transfection 的 silenced 以后,蛋白质降级和 cardiomyocyte 肥大上的 AMPK 的效果被堵住。这些结果显示 AMPK 由经由表明小径的 FOXO3a/MAFbx 激活蛋白质降级在 cardiomyocyte 肥大的抑制起一个重要作用。 | Baolin Chen Qiang WU Zhaojun Xiong Yuedong Ma Sha Yu Dandan Chen Shengwen Huang Yugang Dong | 2016 | Acta Biochimica et Biophysica Sinica2016，48，9： | 4 |
| 10 | ^(99m)Tc-3P_4 -RGD_2 radiotracers for SPECT/CT of esophageal tumor显示文摘In recent years,several RGD(Arg-Gly-Asp)-based radiotracers have already been successfully tested in human for the visualization of integrin αvβ3,demonstrating its feasibility in tumor diagnosis.In this paper,we evaluated the 99mTc-3P4-RGD2 single photon emission computed tomography/computerized tomography(SPECT/CT)in patients suffering from space occupying disease of esophagus.40 patients(34 males and 6 female;mean age: 58.3 years) with a suspected space occupying lesion of esophagus were included,thus finally obtaining their definite pathologic diagnosis(malignant,n=32;benign,n=8).All patients underwent endoscopic,barium esophagography and SPECT/CT imaging preoperatively.The chest SPECT was performed at 4 h after administration of99mTc-3P4-RGD2 with a dose of 939±118 MBq.The diagnosis precision,sensitivity and specificity among these methods were compared.The relationship between radioactive uptake and clinical pathological stage of esophageal carcinoma was discussed by calculating the tumor to normal esophagus(T/N).Meanwhile,the integrin αvβ3 expression was assessed immunohistochemically in postoperative esophageal tissues.31 patients were diagnosed as esophageal carcinoma;and 1,leiomyosarcoma;and 6.leimyoma;and 2,esophageal tuberculosis.The accuracy,sensitivity and specificity of barium esophagography,endoscopic and SPECT/CT imaging are 92.5/93.8/87.5%,97.5/96.9/100%,and 90/90.6/87.5%,respectively.Abnormal accumulation of radiotracer in 29 malignant lesions is observed.The SPECT/CT imaging displayed the region of radioactive uptake and lesions matched extremely with the T/N ratio from 1.31 to 2.79(mean 2.04).A case with pulmonary metastases and a case with mediastinal lymph node metastases were found which were missed by barium esophagography and endoscopic.The99mTc-3P4-RGD2 uptake of the esophageal carcinoma masses had no relevance to the tumor pathologic classification(P>0.05).There was a significant positive correlation between T/N ratio and positive cell percentage of integrin αvβ3(r=0.976),demonstrating the certain clinical potential in the diagnosis of esophageal carcinoma. | GAO Shi MA Qingjie WEN Qiang JIA Bing LIU Zhaofei CHEN Zuowei ZHANG Haishan LI Dandan | 2013 | Nuclear Science and Techniques2013，24，4： | 3 |
| 11 | Ti-based glassy alloys in Ti-Cu-Zr-Sn system显示文摘Bulk amorphous formation in Ti-Cu-based multicomponent alloys, free of Ni, Pd and Be elements, were studied using the cluster-plus-glue-atom model. The basic cluster formula was revealed as [Ti9Cu6]Cu3 to explain the best binary glass forming composition Ti50Cu50 =Ti9Cu9 , where the CN14 rhombi-dodecahedron Ti9Cu6 was the principal cluster in the devitrification phase CuTi. This basic cluster formula was further alloyed with Zr and Sn and a critical glass forming ability was reached at (Ti7.2Zr1.8)(Cu8.72Sn0.28) and (Ti7.2Zr1.8)(Cu8.45Sn0.55) up to 5 mm in diameter by suction casting, which was the largest in Ti-Cu- based and Ni-, Pd- and Be-free alloys. | WANG ZengRui DONG DanDan QIANG JianBing WANG Qing WANG YingMin DONG Chuang | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，7： | 2 |
| 12 | Frequent RNF43 mutation contributes to moderate activation of Wnt signaling in colorectal signet-ring cell carcinoma显示文摘Dear Editor,Signet-ring cell carcinoma(SRCC)is a rare subtype of colorectal cancer(CRC)characterized histologically by the accumulation of mucins in the cytoplasm and displacement of nuclei to the cellular periphery,accounting for about 1%CRC(Fig.S1A)(Borger et al.,2007).Compare to common subtypes of CRC,such as adenocarcinoma(AC)and mucinous adenocarcinoma(MAC),SRCC is associated with aggressive behaviors and younger age at presentation(Kang et al.,2005;Sung et al.,2008;Nitsche et al.,2013;Hugen et al.,2014;Inamura et al.,2015).A retrospective analysis of CRC patient's data at Fudan University Shanghai Cancer Center(FUSCC)also indicated a worse overall and disease-free survival of SRCC patients(Fig.S1B and S1C,Table S1). | Yaqi Li Jian Li Renjie Wang Long Zhang Guoxiang Fu Xueying Wang Yebin Wang Chuantao Fang Dandan Zhang Duo Du Xiaoji Ma Mengxue Pan Qiang Guo Xiaoya Xu Xiang Hu Yi Zhou Shaobo Mo Huijun Wang Jianjun Gao Shenglin Huang Yun Liu Sanjun Cai Guoqiang Hua Junjie Peng Fa-Xing Yu | 2020 | Protein & Cell2020，11，4： | 2 |
| 13 | Sensing carboxylesterase 1 in living systems by a practical and isoformspecific fluorescent probe显示文摘Carboxylesterase 1(CES1), one of the most abundant serine hydrolases in mammals, has drawn much attentions in recent years, owing to this enzyme involves in many physiological processes via hydrolysis of both endogenous esters and xenobiotic esters. Herein, to real-time monitor the activities of CES1 in various biological systems, a practical and iso form-specific fluorescent probe was developed on the basis of the substrate preference of CES1, as well as the structural and optical properties of BODIPY dyes. After screening of a panel of BODIPY ester derivatives, probe 1 displayed the best combination of specificity,sensitivity, enzymatic kinetics and applicability for monitoring CES1 activities in real samples. This probe was successfully used to detect CESl activities in several biological systems including tissue preparations,living cells, tissue slices and zebrafish. Furthermore, the biomedical applications of probe 1 for screening of CES1 inhibitors were also demonstrated using tissue preparations or living cells as enzyme sources. In summary, a practical and broadly applicable tool for real-time monitoring CES1 in biological systems was developed and well-characterized, which held great promise for further investigations on CES1-associated drug discovery, clinical practice and fundamental research. | Lele Ding Zhenhao Tian Jie Hou Tongyi Dou Qiang Jin Dandan Wang Liwei Zou Yadi Zhu Yunqing Song Jingnan Cui Guangbo Ge | 2019 | Chinese Chemical Letters2019，30，3： | 2 |
| 14 | Simultaneous enhancement of stiffness and toughness in hybrid double-network hydrogels via the first, physically linked network显示文摘 | Chen Qiang Wei Dandan Chen Hong | 2015 | Macromolecules2015，48，21： | 1 |
| 15 | Preparation and characterization of galactosylated bovine serum albumin nanoparticles for liver-targeted delivery of oridonin显示文摘 | Caiyun Li Dianrui Zhang Hejian Guo Leilei Hao Dandan Zheng Guangpu Liu Jingyi Shen Xiaona Tian Qiang Zhang | 2013 | International Journal of Pharmaceutics2013，，1： | 1 |
| 16 | Was Wuhan the early epicenter of the COVID-19 pandemic?——a critique显示文摘Recently, Worobey et al.(2022) published a report entitled ‘The Huanan Seafood Wholesale Market in Wuhan was the early epicenter of the COVID-19 pandemic' that succinctly summarizes their study [1]. A pre-print version of this study had earlier elicited a series of highprofile media coverages [2,3]. All these reports deliver a social-political message that the Huanan market is the epicenter of COVID-19. | Yanan Cao Lingling Chen Hua Chen Yupeng Cun Xiaofeng Dai Hongli Du Feng Gao Fengbiao Guo Yalong Guo Pei Hao Shunmin He Shunping He XiongLei He Zheng Hu Boon-Peng Hoh Xin Jin Qian Jiang Qinghua Jiang Asifullah Khan Hong-Zhi Kong Jinchen Li Shuai Cheng Li Ying Li Qiang Lin Jianquan Liu Qi Liu Jian Lu Xuemei Lu Shujin Luo Qinghua Nie Zilong Qiu Tieliu Shi Xiaofeng Song Jianzhong Su Sheng-ce Tao Chaolong Wang Chuan-Chao Wang Guo-Dong Wang Jiguang Wang Qi Wu Shaoyuan Wu Shuhua Xu Yu Xue Wenjun Yang Zhaohui Yang Kai Ye Yuan-Nong Ye Li Yu Fangqing Zhao Yiqiang Zhao Weiwei Zhai Dandan Zhang Liye Zhang Houfeng Zheng Qi Zhou Tianqi Zhu Ya-ping Zhang | 2023 | National Science Review2023，10，4： | 0 |
| 17 | Near-infrared responsive shape memory hydrogels with programmable and complex shape-morphing显示文摘In this work,semi-crystalline nanocomposite hydrogels(i.e.,PAAmA_(11)A/GO gels)were synthesized by micellar copolymerization of acrylamide and N-acryloyl-11-aminoundecanoic acid(A_(11)A)in the presence of a large amount of sodium dodecyl sulfonate(SDS)micelles and GO nanosheets.The resulting hydrogels(SMHs)not only demonstrated high strength and high toughness,but also exhibited good shape memory property.Because of near-infrared(NIR)light absorbability of GO nanosheets,shape recovery and shape of PAAmA_(11)A/GO gels could be tuned by NIR irradiation.Moreover,bilayer hydrogels and trilayer hydrogels were also fabricated by the integration of shape-memorized PAAmA_(11)A/GO gel and elastic hydrophobic associated hydrogel(E-gel).Based on the NIR-responsive shape memory property and layered structure,shape deformation of bilayer hydrogels and trilayer hydrogels was rather different from the single PAAmA_(11)A/GO gel.Each kind of gel structure exhibited diverse and complex shapes via programmable NIR irradiation.More importantly,the shape morphing of NIR-SMHs-based hydrogels could mimic the hand and flower and be used as actuators. | WANG QiLin ZHU Lin WEI DanDan SUN Huan TANG Chen LIU Zhao LI Ke YANG Jia QIN Gang SUN GengZhi CHEN Qiang | 2021 | Science China(Technological Sciences)2021，64，8： | 0 |
| 18 | Inhibition of Wnt activity improves peri-implantation development of somatic cell nuclear transfer embryos显示文摘Somatic cell nuclear transfer(SCNT) can reprogram differentiated somatic cells into totipotency.Although pre-implantation development of SCNT embryos has greatly improved,most SCNT blastocysts are still arrested at the peri-implantation stage,and the underlying mechanism remains elusive.Here,we develop a 3D in vitro culture system for SCNT peri-implantation embryos and discover that persistent Wnt signals block the naive-to-primed pluripotency transition of epiblasts with aberrant H3K27me3 occupancy,which in turn leads to defects in epiblast transformation events and subsequent implantation failure.Strikingly,manipulating Wnt signals can attenuate the pluripotency transition and H3K27me3 deposition defects in epiblasts and achieve up to a 9-fold increase in cloning efficiency.Finally,single-cell RNA-seq analysis reveals that Wnt inhibition marke dly enhances the lineage developmental trajectories of SCNT blastocysts during peri-implantation development.Overall,these findings reveal diminished potentials of SCNT blastocysts for lineage specification and validate a critical peri-implantation barrier for SCNT embryos. | Yanhe Li Caihong Zheng Yingdong Liu Jincan He Qiang Zhang Yalin Zhang Xiaochen Kou Yanhong Zhao Kuisheng Liu Dandan Bai Yanping Jia Xiaoxiao Han Yifan Sheng Jiqing Yin Hong Wang Shuai Gao Wenqiang Liu Shaorong Gao | 2023 | National Science Review2023，10，9： | 0 |
| 19 | Penetrating Atherosclerotic Ulcer with Elevated Troponin in A Patient with Old Myocardial Infarction: A Case Report显示文摘Penetrating atherosclerotic ulcer(PAU),an uncommon etiology of acute aortic syndrome(AAS),is a potential cause of chest pain seen in emergency departments.As PAU may lead to electrocardiogram(ECG)changes or rarely,elevated troponin levels,it is most likely misdiagnosed as acute coronary syndrome(ACS).Hence,individuals with PAU may be offered potentially life-threatening treatment.This paper reports a case of a 81-year-old male who presented with intermittent chest pain with a history of old inferior myocardial infarction and stent placement in the left circumflex coronary artery(LCX)three years ago.Initially,he was diagnosed with non-ST-elevation myocardial infarction(NSTEMI)based on abnormal ECG changes and raised troponin I.However,emergency coronary angiography(CAG)showed no restenosis in the left circumflex coronary artery(LCX)but with mild stenosis in the left anterior descending artery(LAD)and right coronary artery(RCA).Computed tomographic angiography(CIA)of the whole aorta showed multiple atherosclerotic plaques with penetrating atherosclerotic ulcer in the aortic arch and descending aorta.Endovascular aortic repair with Ankura II covered stent was performed.This case study reminds us that it is clinically difficult to distinguish PAU from ACS.Upon excluding ACS from the diagnosis,we should take into consideration of PAU,especially in elderly patients with positive cTnI. | Peiyao Ma Shenke Kong Kun Wang Xin Wang Xuejun Zhang Dandan Li Qiang Zhao Fayun Zhao Xiangdong Zhou Shuai Ji | 2022 | Journal of Clinical and Nursing Research2022，6，3： | 0 |
| 20 | Optical substrates for drug-metabolizing enzymes: Recent advances and future perspectives显示文摘Drug-metabolizing enzymes(DMEs),a diverse group of enzymes responsible for the metabolic elimination of drugs and other xenobiotics,have been recognized as the critical determinants to drug safety and efficacy.Deciphering and understanding the key roles of individual DMEs in drug metabolism and toxicity,as well as characterizing the interactions of central DMEs with xenobiotics require reliable,practical and highly specific tools for sensing the activities of these enzymes in biological systems.In the last few decades,the scientists have developed a variety of optical substrates for sensing human DMEs,parts of them have been successfully used for studying target enzyme(s)in tissue preparations and living systems.Herein,molecular design principals and recent advances in the development and applications of optical substrates for human DMEs have been reviewed systematically.Furthermore,the challenges and future perspectives in this field are also highlighted.The presented information offers a group of practical approaches and imaging tools for sensing DMEs activities in complex biological systems,which strongly facilitates high-throughput screening the modulators of target DMEs and studies on drug/herb-drug interactions,as well as promotes the fundamental researches for exploring the relevance of DMEs to human diseases and drug treatment outcomes. | Qiang Jin Jing Jing Wu Yue Wu Hongxin Li Moshe Finel Dandan Wang Guangbo Ge | 2022 | Acta Pharmaceutica Sinica B2022，12，3： | 0 |
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