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| 1 | Mettl3-/Mettl14-mediated mRNA N6-methyladenosine modulates murine spermatogenesis显示文摘精子发生在双 spermatogonial 干细胞(SSC ) 哪个生产 haploid 精子期间是一个区别过程。这个高度专业化的过程精确在 transcriptional, posttranscriptional,和翻译层次被控制。这里,我们报导那 N 6-methyladenosine (m 6 一) ,调整基因表示的一个 epitranscriptomic 标记,在精子发生期间起必要作用。我们现在的全面 m 6 从五个发展阶段的老鼠 spermatogenic 房间的 mRNA methylomes:无差别的 spermatogonia,类型 A 1 spermatogonia, preleptotene spermatocytes, pachytene/diplotene spermatocytes,和圆 spermatids。m 6 有 Vasa-Cre 的 RNA methyltransferase Mettl3 或 Mettl14 引起 m 6 SSC 的 A 和弄空。m 6 为 SSC 增长 / 区别被要求的抄本的一个弄空 dysregulates 翻译。在有 Stra8-GFPCre 的先进细菌房间的 Mettl3 和 Mettl14 的联合删除破坏精子形式,而有在先进细菌房间的 Mettl3 或 Mettl14 的单个删除的老鼠显示出正常精子发生。从双异种老鼠展览的 spermatids 损害了为精子形式是必要的 haploid 特定的基因的翻译。这研究加亮 mRNA m 6 在 germline 开发的修正,潜在地保证在精子发生的不同阶段协调了翻译。 | Zhen Lin Phillip J Hsu Xudong Xing Jianhuo Fang Zhike Lu Qin Zou Ke-Jia Zhang Xiao Zhang Yuchuan Zhou Teng Zhang Youcheng Zhang Wanlu Song Guifang Jia Xuerui Yang Chuan He Ming-Han Tong | 2017 | Cell Research2017，27，10： | 61 |
| 2 | 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘象 5-methylcytosine (5mC ) 和 5-hydroxymethylcytosine (5hmC ) 那样的 DNA 修正是知道在哺乳动物影响全球基因表示的 epigenetic 标记。在人的染色体,与基因表示的靠近的关联和高化学的稳定性给他们的流行,这些 DNA epigenetic 标记能为癌症用作理想的 biomarkers 诊断。利用一种高度敏感、选择的化学标记技术,我们这里报导在传播没有房间的 DNA ( cfDNA )并且在从最近与 colorectal 诊断的 260 个病人的一个队收集的配对的肿瘤和邻近的纸巾的 genomic DNA ( gDNA )的 5hmC 的染色体宽的介绍,胃,胰腺,从 90 个健康个人的肝或甲状腺癌症和正常纸巾。5hmC 主要在与开的染色质和容许的 histone 修正重合的 transcriptionally 活跃的区域被散布。柔韧的联系癌症的 5hmC 签名在 cfDNA 被识别为特定的癌症类型是特征的。传播 cfDNA 的 5hmC 底 biomarkers colorectal 和胃的癌症是高度预兆的并且比常规 biomarkers 优异并且比得上从织物活体检视的 5hmC biomarkers。因此,这新策略能从血样品的分析为癌症的诊断和预后导致有效、最低限度地侵略的方法的发展。 | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2017 | Cell Research2017，27，10： | 30 |
| 3 | Pharmacokinetics and disposition of anlotinib, an oral tyrosine kinase inhibitor, in experimental animal species显示文摘 | Chen-chun ZHONG Feng CHEN Jun-ling YANG Wei-wei JIA Li LI Chen CHENG Fei-fei DU Su-ping ZHANG Chengying XIE Na-ting ZHANG Olajide E OLALEYE Feng-qing WANG Fang XU Li-guang LOU Dong-ying CHEN Wei NIU Chuan LI | 2018 | Acta Pharmacologica Sinica2018，39，6： | 24 |
| 4 | Surface settlement caused by twin-parallel shield tunnelling in sandy cobble strata显示文摘City metro tunnels are usually constructed as twin-parallel tunnels and their adjacent construction may lead to surface deformation,affecting the surface environment and the safety of the tunnels.Due to its strong dispersion,sandy cobble strata can be easily disturbed by shield tunneling.Based on the project of the Chengdu Metro Line 1,field and model tests were carried out to study the surface settlement caused by shield tunneling in sandy cobble strata by measuring surface settlement curves,ground loss ratios and construction influence zones.The discrete element method(DEM) was used to study the factors affecting the formation of ground arches in sandy cobble strata at the microscopic level.Results show that the shape of the surface settlement curve in sandy cobble strata is different from that in soft soil.The buried depth and clear spacing of the two tunnels had a significant impact on the formation of ground arches. | Chuan HE Kun FENG Yong FANG Ying-chao JIANG | 2012 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2012，13，11： | 21 |
| 5 | Suppression of m6A reader Ythdf2 promotes hematopoietic stem cell expansion显示文摘 | Zhenrui Li Pengxu Qian Wanqing Shao Hailing Shi Xi C. He Madelaine Gogol Zulin Yu Yongfu Wang Meijie Qi Yunfei Zhu John M. Perry Kai Zhang Fang Tao Kun Zhou Deqing Hu Yingli Han Chongbei Zhao Richard Alexander Hanzhang Xu Shiyuan Chen Allison Peak Kathyrn Hall Michael Peterson Anoja Perera Jeffrey S. Haug Tari Parmely Hua Li Bin Shen Julia Zeitlinger Chuan He Linheng Li | 2018 | Cell Research2018，28，9： | 18 |
| 6 | Sensitive assay for measurement of volatile borneol, isoborneol, and the metabolite camphor in rat pharmacokinetic study of Borneolum (Bingpian) and Borneolum syntheticum (synthetic Bingpian)显示文摘 | Chen CHENG Xin-wei LIU Fei-fei DU Mei-juan LI Fang XU Feng-qing WANG Yang LIU Chuan LI Yan SUN | 2013 | Acta Pharmacologica Sinica2013，34，10： | 15 |
| 7 | Pharmacokinetics and disposition of monoterpene glycosides derived from Paeonia lactiflora roots (Chishao) after intravenous dosing of antiseptic XueBiJing injection in human subjects and rats显示文摘瞄准:从 Paeonia lactiflora 根(Chishao ) 导出的 Monoterpene glycosides 被相信为防腐草药的注射 XueBiJing pharmacologically 重要。这研究被设计描绘 monoterpene glycosides.Methods 的 pharmacokinetics 和布置:到 Chishao monoterpene glycosides 的全身的暴露在收到静脉内的注入和 XueBiJing 注射的多重注入的人的题目被估计,由对主要传播混合物的 pharmacokinetics 的评价列在后面。支持的老鼠研究也被执行。膜渗透和血浆蛋白质绑定在 vitro.Results 被估计:18 monoterpene glycosides 的一个总数在 XueBiJing 注射被检测(内容层次, 0.001-2.47 mmol/L ) ,并且 paeoniflorin 说明了检测的 monoterpene glycosides 的 85.5% 全部的剂量。在人的题目,未改变的 paeoniflorin 与 1.2-1.3 h 的消除一半生活展出了全身的暴露的可观的层次;没有重要代谢物被检测。Oxypaeoniflorin 和 albiflorin 展出了低暴露层次,并且留下的次要的 monoterpene glycosides 可以忽略或未被发现。Glomerular-filtration-based 肾的排泄是 paeoniflorin 的主要消除小径,它血浆蛋白质糟糕一定。在老鼠,当剂量被增加, paeoniflorin 的全身的暴露水平按比例增加了。老鼠肺,心,和 paeoniflorin 的肝暴露层次比血浆水平低,与肾水平的例外,它是比血浆水平大的 4.3 褶层;大脑穿入被差的膜 permeability.Conclusion 限制:由于它的重要全身的暴露和适当 pharmacokinetic 侧面,以及以前报导了防腐性质, paeoniflorin 是治疗学的重要性的有希望的 XueBiJing 成分。 | Chen CHENG Jia-zhen LIN Li LI Jun-ling YANG Wei-wei JIA Yu-hong HUANG Fei-fei DU Feng-qing WANG Mei-juan LI Yan-fen LI Fang XU Na-ting ZHANG Olajide E. OLALEYE Yan SUN Jian LI Chang-hai SUN Gui-ping ZHANG Chuan LI | 2016 | Acta Pharmacologica Sinica2016，37，4： | 15 |
| 8 | Driving and Braking Control of PM Synchronous Motor Based on Low-resolution Hall Sensor for Battery Electric Vehicle显示文摘Resolvers are normally employed for rotor positioning in motors for electric vehicles,but resolvers are expensive and vulnerable to vibrations.Hall sensors have the advantages of low cost and high reliability,but the positioning accuracy is low.Motors with Hall sensors are typically controlled by six-step commutation algorithm,which brings high torque ripple.This paper studies the high-performance driving and braking control of the in-wheel permanent magnetic synchronous motor(PMSM) based on low-resolution Hall sensors.Field oriented control(FOC) based on Hall-effect sensors is developed to reduce the torque ripple.The positioning accuracy of the Hall sensors is improved by interpolation between two consecutive Hall signals using the estimated motor speed.The position error from the misalignment of the Hall sensors is compensated by the precise calibration of Hall transition timing.The braking control algorithms based on six-step commutation and FOC are studied.Two variants of the six-step commutation braking control,namely,half-bridge commutation and full-bridge commutation,are discussed and compared,which shows that the full-bridge commutation could better explore the potential of the back electro-motive forces(EMF),thus can deliver higher efficiency and smaller current ripple.The FOC braking is analyzed with the phasor diagrams.At a given motor speed,the motor turns from the regenerative braking mode into the plug braking mode if the braking torque exceeds a certain limit,which is proportional to the motor speed.Tests in the dynamometer show that a smooth control could be realized by FOC driving control and the highest efficiency and the smallest current ripple could be achieved by FOC braking control,compared to six-step commutation braking control.Therefore,FOC braking is selected as the braking control algorithm for electric vehicles.The proposed research ensures a good motor control performance while maintaining low cost and high reliability. | GU Jing OUYANG Minggao LI Jianqiu LU Dongbin FANG Chuan MA Yan | 2013 | Chinese Journal of Mechanical Engineering2013，26，1： | 14 |
| 9 | Chinese Hα Solar Explorer(CHASE)——a complementary space mission to the ASO-S显示文摘The Chinese HαSolar Explorer(CHASE)is designed to test a newly developed satellite platform and conduct solar observations.The scientific payload of the satellite is an Hαimaging spectrograph(HIS),which can,for the first time,acquire full-disk spectroscopic solar observations in the Hαwaveband.This paper briefly introduces CHASE/HIS including its scientific objectives,technical parameters,scientific application system,etc.The CHASE mission is scheduled to launch in 2021.It will complement the observations by on-orbit solar spacecraft(such as SDO,IRIS,STEREO and PSP),as well as future solar missions of the Solar Orbiter and Advanced Space-based Solar Observatory(ASO-S). | Chuan Li Cheng Fang Zhen Li Ming-De Ding Peng-Fei Chen Zhe Chen Liang-Kui Lin Chang-Zheng Chen Chang-Ya Chen Hong-Jiang Tao Wei You Qi Hao Yu Dai Xin Cheng Yang Guo Jie Hong Min-Jie An Wei-Qiang Cheng Jian-Xin Chen Wei Wang Wei Zhang | 2019 | Research in Astronomy and Astrophysics2019，19，11： | 12 |
| 10 | Sequencing of p53 mutation in established human hepatocellular carcinoma cell line of HHC4 and HHC15 in nude mice显示文摘INTRODUCTIONAlthoughtheetiopathologyofhumanhepatocelularcarcinoma(hHCC)isstilunknown,alotofevidencestronglysuggestedthatinfec... | YANG Shan Min, ZHOU Hong, CHEN Rui Chuan, WANG Yu Fang, CHEN Fu, ZHANG Chang Gong, ZHEN Yun, YAN Jiang Hua and SU Jin Hua | 1998 | World Journal of Gastroenterology1998，4，6： | 11 |
| 11 | Human pharmacokinetics of ginkgo terpene lactones and impact of carboxylation in blood on their platelet-activating factor antagonistic activity显示文摘Terpene lactones are a class of bioactive constituents of standardized preparations of Ginkgo biloba leaf extract, extensively used as add-on therapies in patients with ischemic cardiovascular and cerebrovascular diseases. This investigation evaluated human pharmacokinetics of ginkgo terpene lactones and impact of their carboxylation in blood. Human subjects received oral YinXing- TongZhi tablet or intravenous ShuXueNing, two standardized ginkgo preparations. Their plasma protein-binding and plateletactivating factor antagonistic activity were assessed in vitro. Their carboxylation was assessed in phosphate-buffered saline (pH 7.4) and in human plasma. After dosing YinXing-TongZhi tablet, ginkgolides A and B and bilobalide exhibited significantly higher systemic exposure levels than ginkgolides C and J; after dosing ShuXueNing, ginkgolides A, B, C, and J exhibited high exposure levels. The compounds’ unbound fractions in plasma were 45–92%. Apparent oral bioavailability of ginkgolides A and B was mostly >100%, while that of ginkgolides C and J was 6–15%. Bilobalide’s bioavailability was probably high but lower than that of ginkgolides A/B. Terminal half-lives of ginkgolides A, B, and C (4–7 h) after dosing ShuXueNing were shorter than their respective values (6–13 h) after dosing YinXing-TongZhi tablet. Half-life of bilobalide after dosing the tablet was around 5 h. Terpene lactones were roughly evenly distributed in various body fluids and tissues; glomerular-filtration-based renal excretion was the predominant elimination route for the ginkgolides and a major route for bilobalide. Terpene lactones circulated as trilactones and monocarboxylates. Carboxylation reduced platelet-activating factor antagonistic activity of ginkgolides A, B, and C. Ginkgolide J, bilobalide, and ginkgo flavonoids exhibited no such bioactivity. Collectively, differences in terpene lactones’ exposure between the two preparations and influence of their carboxylation in blood should be considered in investigating the relative contributions of terpene lactones to ginkgo preparations’ therapeutic effects. The results here will inform rational clinical use of ginkgo preparations. | Xin-wei Liu Jun-ling Yang Wei Niu Wei-wei Jia Olajide E.Olaleye Qi Wen Xiao-na Duan Yu-hong Huang Feng-qing Wang Fei-fei Du Chen-chun Zhong Yan-fen Li Fang Xu Qi Gao Li Li Chuan Li | 2018 | Acta Pharmacologica Sinica2018，39，12： | 8 |
| 12 | Malnutrition and Quality of Life in Chinese Cancer Patients: a Clinical Study of 23,994 Subjects显示文摘Background Malnutrition is common in patients with cancer,and can negatively impact their quality of life(QoL)and even survival.However,there is currently no large data available on the prevalence of malnutrition in Chinese cancer patients.This study evaluated the prevalence of malnutrition and the QoL of Chinese patients with locoregional,recurrent or metastatic cancer.Methods We conducted a nationwide observational,multi-center,hospital-based cross-sectional study within the Chinese Society of Nutritional Oncology(CSNO)Network.All of the patients were diagnosed with one of the following 18 different types of malignant tumors:lung cancer,gastric cancer,liver cancer,colorectal cancer,breast cancer,esophageal cancer,cervical cancer,endometrial cancer,nasopharyngeal carcinoma,malignant lymphoma,leukemia,pancreatic cancer,ovarian cancer,prostate cancer,bladder cancer,brain cancer,biliary tract malignant tumors or gastrointestinal stromal tumors.These patients were enrolled from 72 hospitals located in different regions of China.The patients’nutritional status was evaluated based on the body mass index(BMI),loss of bodyweight,laboratory measurements and patient generated-subjective global assessment(PG-SGA)scores.The cancer patients’physical status and QoL were assessed by the Karnofsky Performance Status(KPS)questionnaire and the European Organization for Research and Treatment of Cancer(EORTC)QLQ-C30 questionnaire,respectively.Results From December 2013 to April 2016,23,994 patients hospitalized for cancer treatment(such as surgery,chemotherapy or radiotherapy)were enrolled in the study.The patients included 12,494(52.9%)males and 11,124(47.1%)females.The mean age was 55.8±13.7 years.The proportions of patients in cancer stagesⅠ,Ⅱ,Ⅲ,Ⅳand uncertain were 11.5%,20.3%,27.5%,30.2%and 10.5%,respectively.Among the 23,994 inpatients,the proportions of patients who were underweight(BMI<18.5 kg/m2),normal(18.5 kg/m2 | Hong Xia Xu Chun Hua Song Zhen Ming Fu Chang Wang Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Fu Xiang Zhou Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Min Weng Qing Hua Yao Jiu Wei Cui Wei Li Han Ping Shi the Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group | 2021 | Journal of Nutritional Oncology2021，6，1： | 8 |
| 13 | Detection of serum IgM and IgG for COVID-19 diagnosis显示文摘Dear Editor,Infection with the novel coronavirus(SARS-CoV-2,which is the virus responsible for the coronavirus disease 2019(COVID-19))was first reported in Wuhan,China on December 31,2019.The outbreak of COVID-19 remains ongoing and was linked to more than 80,000 infected patients and more than 3,000 deaths in China as of March 7,2020(Holshue et al.,2020). | Ling Zhong Junlan Chuan Bo Gong Ping Shuai Yu Zhou Yi Zhang Zhilin Jiang Dingding Zhang Xiaoqi Liu Shi Ma Yi Huang He Lin Qingwei Wang Lulin Huang Dan Jiang Fang Hao Juan Tang Chunqi Zheng Hua Yu Zhibin Wang Qi Jiang Tao Zeng Mei Luo Fanwei Zeng Fanxin Zeng Jianghai Liu Junxi Tian Yu Xu Tengxiang Long Kaiju Xu Xingxiang Yang Yuping Liu Yi Shi Li Jiang Zhenglin Yang | 2020 | Science China(Life Sciences)2020，63，5： | 8 |
| 14 | The Chinese Hα Solar Explorer(CHASE) mission: An overview显示文摘The Chinese Hα Solar Explorer(CHASE), dubbed “Xihe”—Goddess of the Sun, was launched on October 14, 2021 as the first solar space mission of China National Space Administration(CNSA). The CHASE mission is designed to test a newly developed satellite platform and to acquire the spectroscopic observations in the Hα waveband. The Hα Imaging Spectrograph(HIS)is the scientific payload of the CHASE satellite. It consists of two observational modes: raster scanning mode and continuum imaging mode. The raster scanning mode obtains full-Sun or region-of-interest spectral images from 6559.7 to 6565.9 ? and from 6567.8 to 6570.6 ? with 0.024 ? pixel spectral resolution and 1 min temporal resolution. The continuum imaging mode obtains photospheric images in continuum around 6689 ? with the full width at half maximum of 13.4 ?. The CHASE mission will advance our understanding of the dynamics of solar activity in the photosphere and chromosphere. In this paper, we present an overview of the CHASE mission including the scientific objectives, HIS instrument overview, data calibration flow, and first results of on-orbit observations. | Chuan Li Cheng Fang Zhen Li MingDe Ding PengFei Chen Ye Qiu Wei You Yuan Yuan MinJie An HongJiang Tao XianSheng Li Zhe Chen Qiang Liu Gui Mei Liang Yang Wei Zhang WeiQiang Cheng JianXin Chen ChangYa Chen Qiang Gu QingLong Huang MingXing Liu ChengShan Han HongWei Xin ChangZheng Chen YiWei Ni WenBo Wang ShiHao Rao HaiTang Li Xi Lu Wei Wang Jun Lin YiXian Jiang LingJie Meng Jian Zhao | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，8： | 7 |
| 15 | Methylation and its role in the disposition of tanshinol, a cardiovascular carboxylic catechol from Salvia miltiorrhiza roots (Danshen)显示文摘 | Dan-dan TIAN Wei-wei JIA Xin-wei LIU Dan-dan WANG Jun-hua LIU Jia-jia DONG Li LI Fei-fei DU Fang XU Feng-qing WANG Yan SUN Yu-xing HUANG Mei-juan LI Li-hong HU Yan ZHU Xiu-mei GAO Chuan LI Jun-ling YANG | 2015 | Acta Pharmacologica Sinica2015，36，5： | 7 |
| 16 | Validity of the Chinese Version of the Patient-Generated Subjective Global Assessment (PG-SGA) in Lung Cancer Patients显示文摘The prevalence of malnutrition is high among oncology patients in China. Although the Patient- Generated Subjective Global Assessment (PG-SGA) is widely recognized as an important nutritional assessment tool, it has not been validated for Chinese cancer patients. The purpose of this study was to conduct an analysis of nutrition screening and assessment data to validate the Chinese version of the PG-SGA in Chinese patients with lung cancer. This was an observational, cross-sectional study of 2,000 consecutive adult patients with lung cancer treated at several tertiary hospitals in China. Anthropometric and patient descriptive data were collected. The PG-SGA generated a score for the nutritional risk and a global rating for the nutritional status. The internal consistency, external consistency, and construct validity were evaluated, and a known-groups comparison and principal component analyses were conducted to evaluate the reliability and validity of the PG-SGA. The known-groups comparison demonstrated the ability of the PG-SGA to differentiate lung cancer patients of different nutritional and body mass index (BMI) groups. A confirmatory factor analysis supported the original four-factor structure of the PG-SGA. In terms of the internal and external consistency, the PG-SGA demonstrated intra-class correlation coefficients (ICC) up to 0.987. Alternative form validity was also demonstrated between Box 4 of the PG-SGA and the Karnofsky Performance Status score, with excellent external consistency (r = 0.972, P < 0.001). The construct validity was supported, and selected questionnaire dimensions were evident in the principal component analysis. Significant Spearman correlations (P < 0.001) were demonstrated. The Chinese version of the PG-SGA demonstrated significant reliability and sufficient exploratory properties to support its validity. It seems to be a valid tool that can be used to access the nutritional status of Chinese lung cancer patients. The validity of the PG-SGA in Chinese cancer patients warrants further investigation in other cancer types. | Zhen Ming Fu Hong Xia Xu Chun Hua Song Wei Li Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Chang Wang Han Ping Shi The Investigation on Nutrition Status and Clinical Outcome of Common Cancers (INSCOC) Group | 2016 | Journal of Nutritional Oncology2016，1，1： | 7 |
| 17 | Multiple circulating saponins from intravenous ShenMai inhibit OATPIBs in vitro: potential joint precipitants of drug interactions显示文摘ShenMai, an intravenous Injection prepared from steamed Hanax ginseng roots (Hongshen) and Ophiopogon japonicus roots (Maidong), is used as an add-on therapy for coronary artery disease and cancer;saponins are its bioactive constituents. Since many saponins inhibit human organic anion-transporting polypeptides (OATP11B, this investigation determined the inhibition potencies of circulating ShenMai saponins on the transporters and the joint potential of these compounds for ShenMai drug interaction. Circulating saponins and their pharmacokinetics were charaaerized in rats receiving a 30-min infusion of ShenMai at 1OmL/kg. Inhibition of human OATP1B1/1B3 and rat Oatplb2 by the individual saponins was investigated in vitro;the compounds, joint inhibition was also assessed in vitro and the data was processed using the Chou-Talalay method. Plasma protein binding was assessed by equilibrium dialysis. Altogether, 49 saponins in ShenMai were characterized and graded into: 10-1OOμmol/day (compound doses from ShenMai;7 compounds), 1-10 μmol/day (17 compounds), and <1μmol/day (25 compounds, including Maidong ophiopogonins). After dosing, circulating saponins were protopanaxadiol-type ginbenosides Rbi, Rb2r Rc, Rd, Rg2, and Ra3, protopanaxatriol-type ginsenosides Rg1, Re, Rg2, and Rf, and ginsenoside Ro. The protopanaxadiol-type ginsenosides exhibited maximum plasma concentrations of 2.1-46.6 μmol/L, plasma unbound fractions of 0.4-1.0% and terminal half-lives of 15.6-28.5 h (ginsenoside Rg3f 1.9 h), while the other ginsenosides exhibited 0.1-77 μmol/L, 20.8-99.2%, and 0.2-0.5 h, respectively. The protopanaxadiol-type ginsenosides, ginsenosides without any sugar attachment at C-20 (except ginsenoside Rf), and ginsenoside Ro inhibited OATP1B3 more potently (IC50, 0.2-3.5 (μmol/L) than the other ginsenosides (≥22.6 μmol/L). Inhibition of OATP1B1 by ginsenosides was less potent than OATP1B3 inhibition. Ginsenosides Rb1;Rb2, Rc, Rd, Ro, Ra1, Re, and Rg2 likely contribute the major part of OATP1B3-mediated ShenMai-drug interaction potential, in an additive and time-related manner. | Olajide E. Olaleye Wei Niu Fei-fei Du Feng-qing Wang Fang Xu Salisa Pintusophon Jun-lan Lu Jun-ling Yang Chuan Li | 2019 | Acta Pharmacologica Sinica2019，40，6： | 7 |
| 18 | Impact of shield tunneling on adjacent spread foundation on sandy cobble strata显示文摘The section of shield tunnel of the Chengdu Metro line passes primarily through sandy cobble strata.There are many buildings with spread foundations along the lines. Shield tunnel construction will disturb the ground, causing displacement or stress to adjacent spread foundations. Based on the similarity theory, a laboratory model test of shield tunnel driving was carried out to study the influence of shield tunnel excavation on the displacement of adjacent spread foundation. The results show that foundation closer to the tunnel has greater displacement or settlement than that further away. The horizontal displacement is small and is influenced greatly by the cutting face. The displacement along the machine driving direction is bigger and is significantly affected by the thrust force.Settlement occurs primarily when shield machine passes close to the foundation and is the greatest at that time.Uneven settlement at the bottom of the spread foundation reaches a maximum after the excavation ends. In a numerical simulation, a particle flow model was constructed to study the impact of shield tunnel excavation on the stresses in the ground. The model showed stress concentration at the bottom of the spread foundation. With the increasing ground loss ratio, a loose area appears in the tunnel dome where the contact force dropped. Above the loose area, the contact force increases, forming an archshaped soil area which prevents the loose area from expanding to the ground surface. The excavation also changed the pressure distribution around spread foundation. | Yong Fang Jun Wang Chuan He Xiongyu Hu | 2014 | Journal of Modern Transportation2014，22，4： | 6 |
| 19 | Loss of the posteromedial support:a risk factor for implant failure after fixation of AO 31-A2 intertrochanteric fractures显示文摘Background:The purpose of this study was to analyze cases of AO31-A2 intertrochanteric fractures(ITFs)and to identify the relationship between the loss of the posteromedial support and implant failure.Methods:Three hundred ninety-four patients who underwent operative treatment for ITF from January 2003 to December 2017 were enrolled.Focusing on posteromedial support,the A2 ITFs were divided into two groups,namely,those with(Group A,n=153)or without(Group B,n=241)posteromedial support post-operatively,and the failure rates were compared.Based on the final outcomes(failed or not),we allocated all of the patients into two groups:failed(Group C,n=66)and normal(Group D,n=328).We separately analyzed each dataset to identify the factors that exhibited statistically significant differences between the groups.In addition,a logistic regression was conducted to identify whether the loss of posteromedial support of A2 ITFs was an independent risk factor for fixation failure.The basic factors were age,sex,American Society of Anesthesiologists(ASA)score,side of affected limb,fixation method(intramedullary or extramedullary),time from injury to operation,blood loss,operative time and length of stay.Results:The failure rate of group B(58,24.07%)was significantly higher than that of group A(8,5.23%)(χ2=23.814,P<0.001).Regarding Groups C and D,the comparisons of the fixation method(P=0.005),operative time(P=0.001),blood loss(P=0.002)and length of stay(P=0.033)showed that the differences were significant.The logistic regression revealed that the loss of posteromedial support was an independent risk factor for implant failure(OR=5.986,95%CI:2.667-13.432)(P<0.001).Conclusions:For AO31-A2 ITFs,the loss of posteromedial support was an independent risk factor for fixation failure.Therefore,posteromedial wall reconstruction might be necessary for the effective treatment of A2 fractures that lose posteromedial support. | Kai-Feng Ye Yong Xing Chuan Sun Zhi-Yong Cui Fang Zhou Hong-Quan Ji Yan Guo Yang Lyu Zhong-Wei Yang Guo-Jin Hou Yun Tian Zhi-Shan Zhang | 2020 | Chinese Medical Journal2020，，1： | 6 |
| 20 | Additive Maps Preserving Nilpotent Operators or Spectral Radius显示文摘让 X 一(真实或复杂) 有比 2 大、让的尺寸的 Banach 空间 B_0 (X) B (X) 的潜水艇空间被所有无有势力操作员在 X 上跨越。我们在在两个方向保存无有势力操作员的 B_0 (X) 上得到 surjective 添加剂地图Φ的一个完全的分类。特别地,如果 X 是无限维的,我们证明Φ有形式任何一个Φ(T )=cATA^(-1) 或Φ(T )=cAT'A^(A 的 -1), 一可颠倒跳线性或结合线性操作员, c 是数量, T' 表示 T 的伴随。作为这些结果的应用,我们证明每添加剂 surjective 在 B 上印射保存的(X) 光谱半径与 | c 有一种类似的形式到上面|=1。 | Zhao Fang BAI Jin Chuan HOU | 2005 | Acta Mathematica Sinica,English Series2005，21，5： | 6 |
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