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| 1 | Production of bioactive ginsenoside compound K in metabolically engineered yeast显示文摘 | Xing Yan Yun Fan Wei Wei Pingping Wang Qunfang Liu Yongjun Wei Lei Zhang Guoping Zhao Jianmin Yue Zhihua Zhou | 2014 | Cell Research2014，24，6： | 81 |
| 2 | Geodynamic significance of the A-type granites in the Sawuer region in west Junggar, Xinjiang: Rock geochemistry and SHRIMP zircon age evidence显示文摘Sawuer region is located in west Junggar, Jimunai County of Altay district and Hefeng County of Tacheng district, Xinjiang. The region is along the north margin of Kazakstan-Junggar plate. The intrusions (mainly acid) are widespread. Qiaqihai and Kuoyitasi intrusions are important in the region, with the characteristics of A-type granite. Further investigations indicate that they belong to A2-type granite that formed in extension tectonic setting of post collision. The REE chon-drite-normalized patterns of the intrusions show LREE enrichment and the δ Eu values are lower. The Nd, Sr, Pb isotope compositions of the intrusions indicate a mantle source, while the low δ 18O values resulted from the isotope exchange between intrusion and meteoric water. According to SHRIMP U-Pb age analysis results, the crystallization age of Qiaqihai intrusion is 290.7 ± 9.3 Ma (1σ ), and that of Kuoyitasi intrusion is 297.9 ± 4.6 Ma (1σ ), corresponding to the beginning of early Permian. The A2-type granites indicate that the region was in the extension period of the post-collisional stage at the beginning of early Permian in the Sawuer region. The A-type granites in the Sawuer region in west Junggar discovered from this work is analogous to the A-type granites found in east Junggar of the Ulungur alkali granites belt. The confirmation of post-collisional A-type granites of early Permian in the Sawuer region provides new evidence for the regional vertical continental crust growth in early Per-mian. The former proposed Ulungur alkali granites belt can extend from east Ulungur through west Ulungur and to Zhaisang in Kazakstan westwards. | ZHOU Taofa1, YUAN Feng1, TAN Lugui1,2, FAN Yu1 & YUE Shucang1 1. School of Resources and Environmental Engineering, Hefei University of Technology, Hefei 230009, China 2. Department of Geography and Environment Science, Wanxi College, Liuan 237012, China | 2006 | Science China Earth Sciences2006，49，2： | 42 |
| 3 | Expression and function of classical protein kinase C isoenzymes in gastric cancer cell line and its drugresistant sublines显示文摘AIM: To investigate the expression and function of classicalprotein kinase C (PKC) isoenzymes in inducing MDRphenotype in gastric cancer cells.METHODS: Two cell lines were used in the study: gastriccancer cell SGC7901 and its drug-resistant cell SGC7901/VCRstepwise-selected by vincristine 0.3, 0. 7 and 1.0 mg@ L-1 ,respectively. The expression of classical PKC (cPKC)isoenzymes in SGC7901 cells and SGC7901/VCR cells weredetected using immunofluorescent cytochemistry, laserconfocal scanning microscope and Wsstern blot. The effectsof anti-PKC isoenzymes antibody of adriamycinaccumulation in SGC7901/VCR cells were determined usingflow cytometric analysis.RESULTS: (1) SGC7901 cells exhibited positive staining ofPKC-α. SGC7901/VCR cells exhibited stronger staining ofPKC-α than SGC7901 cells. The higher dosage vincristineselected, the much stronger staining of PKC-α was observedon SGC7901/VCR cells. (2) Both SGC7901 and SGC7901/VCRcells exhibited positive staining of PKC-βⅠ and PKC-βⅡ withno significant difference. ( 3 ) Compared with SGC7901,SGC7901/VCR cells had decreased adriamycin accumulationand retention. Accumulation of adriamycin in SGC7901 was5.21 + 2.56 mg@ L-1, in SGC7901/VCR 0.3 was 0.85 + 0.29 mg@L-1 , in SGC7901/VCR 0.7 was 0.81 + 0.32 og@ L-1 , and inSGC7901NCR 1.0 was 0.80 + 0.33 mg @ L-1; Retention ofadriamycin in SGC 7901 was 2.51 + 1.23 mg@L-1, in SGC7901/VCR 0.3 was 0.47 + 0.14 mg@ L-1 , in SGC7901/VCR 0.7 was 0.44 + 0.15 mg@ L-1, and in SGC 7901/VCR 1.0 was 0.41 + 0.1 1mg @ L-1 . (4) Fluorescence intensity presented adriamycinaccumulation in SGC7901/VCR cells was increased from 1.14+0.36 to 2.71 +0.94 when cells were co-incubated with anti-PKC-αbut not with anti-PKC-βⅠ, PKC-βⅡ and PKCγ antibodies.CONCLUSION: PKC-α, but not PKC-βⅠ, PKC-βⅡ or PKCγ,may play a role in multidrug resistance of gastric cancercells SGC7901/VCR. | Ying Han Zhe-Yi Han Xin-Min Zhou Ru Shi Yue Zheng Yong-Quan Shi Ji-Yan Miao Bo-Rong Pan Dai-Ming Fan | 2002 | World Journal of Gastroenterology2002，8，3： | 25 |
| 4 | Overexpression of Aurora-A kinase promotes tumor cell proliferation and inhibits apoptosis in esophageal squamous cell carcinoma cell line显示文摘曙光 A kinase, serine/threonine 蛋白质 kinase,是潜在的 oncogene。扩大并且在人的肿瘤的几种类型在曙光 A 的表示上被发现了,包括的食道的有鳞的房间癌(ESCC ) 。在表示曙光 A 上的房间对导致 cisplatin 的 apoptosis 更抵抗,这被表明了。然而,调停的分子的机制这些效果仍然保持大部分未知。在这份报告,我们证明在通过在人的 ESCC KYSE150 的 pEGFP-Aurora-A 的稳定的 transfection 的曙光 A 的表示上,房间显著地支持了房间增长并且禁止了 cisplatin- 或紫外导致照耀的 apoptosis。caspase-3 并且 poly 的劈开(自动数据处理核糖) 在在表示房间上的曙光 A 的聚合酶(PARP ) 实质地在 cisplatin 或紫外处理以后被减少。而且,我们发现有 siRNA 的内长的曙光 A kinase 的那 silencing 实质地提高了敏感到导致 cisplatin 或在人的 ESCC EC9706 房间的紫外导致 apoptosis。在平行,在曙光 A 的表示上 potently 起来调整了 Bcl-2 的表示。而且,由废除的 siRNA 的 Bcl-2 击倒 Aurora-A 禁止 apoptosis 上的效果。总起来说,这些数据提供证据在支持房间增长并且禁止 apoptosis 的表示上的那曙光 A,建议是的新奇机制仔细与恶意的显型和 ESCC 房间的反癌症药抵抗有关。 | Xiao Xia Wang Rong Liu Shun Qian Jin Fei Yue Fan Qi Min Zhan | 2006 | Cell Research2006，16，4： | 24 |
| 5 | The Hardy Rubber Tree Genome Provides Insights into the Evolution of Polyisoprene Biosynthesis显示文摘Eucommia ulmoides,也叫的强壮的橡胶树,是一棵经济地重要的树;然而,它的染色体顺序的缺乏 ?限制基本生物研究和这植物种的应用研究。这里,我们在场它的 1.2-Gb 染色体的一个高质量的集会(支架 N50 ?=? 1.88 Mb ) 与至少 26 ? 为 E 的 723 预言的基因。ulmoides,顺序 Garryales 的首先定序的染色体,它用联合定序的 Illumina 的综合策略被获得,定序的 PacBio,和印射的 BioNano。作为到 lamiids 和 campanulids 的姐妹 taxon, E。ulmoides 经历了三倍由核心 eudicots 而是没有进一步整个染色体的复制分享了的一个古老的染色体 ? 在最后 1.25 亿年里。E。ulmoides 为涉及压力回答和第二等的代谢物的生合成的多重基因展出高表达式层次或基因数字扩大,它可以说明它的可观的环境适应性。与橡胶树(Hevea brasiliensis ) 相对照,它生产 cis 聚异式戊二我烯, E。ulmoides 演变综合经由 farnesyl diphosphate synthases (FPS ) 的长链的 trans 聚异式戊二我烯。而且, FPS 和橡胶延伸 factor/small 橡胶粒子蛋白质基因家庭从 H 独立地被扩展。brasiliensis 系。这些结果提供新卓见进 E. 的生物学 ? ulmoides 和聚异式戊二我烯生合成的起源。 | Ta-na Wuyun Lin Wang Huimin Liu Xuewen Wang Liangsheng Zhang Jeffrey L. Bennetzen Tiezhu Li Lirong Yang Panfeng Liu Lanying Du Lu Wang Mengzhen Huang Jun Qing Iili Zhu Wenquan Bao Hongguo Li Qingxin Du Jingle Zhu Hong Yang Shuguang Yang Hui Liu Hui Yue Jiang Hu Suoliang Yu Yu Tian Fan Liang Jingjing Hu Depeng Wang Ruiwen Gao Dejun Li Hongyan Du | 2018 | Molecular Plant2018，11，3： | 24 |
| 6 | Intracoronary nitroprusside in the prevention of the no-reflow phenomenon in acute myocardial infarction显示文摘背景没有回流现象在为尖锐心肌的梗塞(AMI ) 的经皮的冠的干预(一种总线标准) 期间是连续心肌的局部缺血,室的改变和心脏的机能障碍的一个预兆的因素,它仔细与更坏的预后被联系。这研究试图在有 AMI 的 92 个连续病人,在 12 小时发作以内经历了主要一种总线标准,随机被分到 2 个组的 AMI.Methods 在没有回流现象的预防评估 intracoronary nitroprusside:nitroprusside 的 intracoronary 管理(组 A, n=46 ) ,硝化甘油的 intracoronary 管理(组 B, n=46 ) 。angiographic 结果被观察。即时心肌的对比 echocardiography ( RT-MCE )包括对比 20 索引( CSI ),围运动 20 索引( WMSI ), transmural 对比缺点长度( CDL )和严肃的 WM 反常长度( WML )在 24 个小时和 1 星期 post-PCI.High 敏感被记录C反应的蛋白质( Hs-CRP )被有免疫力的率用悬液计测量悬液检验。N 终端 prohormone 大脑 natriu retic 肽(NT-proBNP ) 与连接酶的 immunosorbent 试金被测试。病人们被跟随在上面为六个月。主要不利心脏的事件(向) 在组 B 比那高是在组 A 的最后的 TIMI-3 流动的发生多是的 recorded.Results (P < 0.05 ) ,在组 A 的最后的改正的 TIMI 框架计数(cTFC ) 在组 B 比那显著地减少了(P < 0.01 ) 。在组 A 的 CSI, CDL/LV 长度, WMSI 和 WL/LV 长度在组 B 是比那显著地低的(P < 0.01 ) 。在 1 个星期的 Hs-CRP 和 NT-proBNP 的层次一种总线标准以后在组 B 比那在组 A 显著地减少了(P < 0.01 ) 。病人们被跟随在上面,导致没有回流现象和更好的预后的发生的减少为 6 个月和在组的向的发生, A 是显著地在组 B 比那降低(P < 0.05 ).Conclusion Intracoronary nitroprusside 能改进心肌的 microcirculation。 | PAN Wei WANG Lan-feng YU Jia-hui FAN Ying YANG Shu-sen ZHOU Li-jun LI Yue LI Wei-min | 2009 | Chinese Medical Journal2009，，22： | 22 |
| 7 | Pretreatment with chitosan oligosaccharides attenuate experimental severe acute pancreatitis via inhibiting oxidative stress and modulating intestinal homeostasis显示文摘Severe acute pancreatitis(SAP)is a severe acute abdominal disease.Recent evidence shows that intestinal homeostasis is essential for the management of acute pancreatitis.Chitosan oligosaccharides(COS)possess antioxidant activity that are effective in treating various inflammatory diseases.In this study we explored the potential therapeutic effects of COS on SAP and underlying mechanisms.Mice were treated with COS(200 mg·kg^(−1)·d^(−1),po)for 4 weeks,then SAP was induced in the mice by intraperitoneal injection of caerulein.We found that COS administration significantly alleviated the severity of SAP:the serum amylase and lipase levels as well as pancreatic myeloperoxidase activity were significantly reduced.COS administration suppressed the production of proinflammatory cytokines(TNF-α,IL-1β,CXCL2 and MCP1)in the pancreas and ileums.Moreover,COS administration decreased pancreatic inflammatory infiltration and oxidative stress in SAP mice,accompanied by activated Nrf2/HO-1 and inhibited TLR4/NF-κB and MAPK pathways.We further demonstrated that COS administration restored SAP-associated ileal damage and barrier dysfunction.In addition,gut microbiome analyses revealed that the beneficial effect of COS administration was associated with its ability to improve the pancreatitis-associated gut microbiota dysbiosis;in particular,probiotics Akkermansia were markedly increased,while pathogenic bacteria Escherichia–Shigella and Enterococcus were almost eliminated.The study demonstrates that COS administration remarkably attenuates SAP by reducing oxidative stress and restoring intestinal homeostasis,suggesting that COS might be a promising prebiotic agent for the treatment of SAP. | Qi-xiang Mei Jun-hui Hu Ze-hua Huang Jun-jie Fan Chun-lan Huang Ying-ying Lu Xing-peng Wang Yue Zeng | 2021 | Acta Pharmacologica Sinica2021，42，6： | 21 |
| 8 | Safety Research in Traditional Chinese Medicine: Methods, Applications, and Outlook显示文摘Traditional Chinese medicine (TCM) is a medical system that has collected and summarized abundant clinical experience over its long history of more than 2000 years. However, the frequent occurrence of TCM-induced adverse reactions has hindered the modernization and internationalization of TCM, while attracting increasing attention from around the world. Unlike chemical drugs and biological agents, the difficulties involved in research on the toxicity and safety of TCM mainly include the complexity of its components and the unpredictability of drug–body interactions. Much of TCM, which has overall therapeutic effects, has the typical mechanisms of multiple components, multiple pathways, and multiple targets. While considering the gradualness and unpredictability of TCM toxicity, the ambiguity of toxicants and safe dosage, and individual differences during long-term TCM administration, we have systematically established key techniques for the toxicity assessment of TCM. These techniques mainly include TCM toxicity discovery in an early phase, based on a combination of drug toxicology genomics and metabolomics;methods to identify dose–toxicity relationships in TCM;and integrated techniques for the exploration of TCM interactions, such as fast-screening tests based on drug-metabolizing enzymes and receptor pathways. In particular, we have developed a new technical system for TCM safety evaluation using molecular toxicology, which has been validated well in research on TCM compatibility contraindication, quality control, and allergen discovery. The application of this key technical platform is introduced here in detail. This application includes model organisms, toxicant biomarkers, a magnetic suspension technique, and the application of network toxicology and computational toxicology in research on the toxicity of Fructus toosendan, Semen cassiae, Polygonum multiflorum, and Fructus psoraleae. | Yue Gao Aihua Liang Xiaohui Fan Limin Hu Feiran Hao Yubo Li | 2019 | Engineering2019，5，1： | 19 |
| 9 | Comprehensive metabolomics expands precision medicine for triple-negative breast cancer显示文摘Metabolic reprogramming is a hallmark of cancer.However,systematic characterizations of metabolites in triple-negative breast cancer(TNBC)are still lacking.Our study profiled the polar metabolome and lipidome in 330 TNBC samples and 149 paired normal breast tissues to construct a large metabolomic atlas of TNBC.Combining with previously established transcriptomic and genomic data of the same cohort,we conducted a comprehensive analysis linking TNBC metabolome to genomics.Our study classified TNBCs into three distinct metabolomic subgroups:C1,characterized by the enrichment of ceramides and fatty acids;C2,featured with the upregulation of metabolites related to oxidation reaction and glycosyl transfer;and C3,having the lowest level of metabolic dysregulation.Based on this newly developed metabolomic dataset,we refined previous TNBC transcriptomic subtypes and identified some crucial subtype-specific metabolites as potential therapeutic targets.The transcriptomic luminal androgen receptor(LAR)subtype overlapped with metabolomic C1 subtype.Experiments on patient-derived organoid and xenograft models indicate that targeting sphingosine-1-phosphate(S1P),an intermediate of the ceramide pathway,is a promising therapy for LAR tumors.Moreover,the transcriptomic basal-like immune-suppressed(BLIS)subtype contained two prognostic metabolomic subgroups(C2 and C3),which could be distinguished through machine-learning methods.We show that N-acetyl-aspartyl-glutamate is a crucial tumor-promoting metabolite and potential therapeutic target for high-risk BLIS tumors.Together,our study reveals the clinical significance of TNBC metabolomics,which can not only optimize the transcriptomic subtyping system,but also suggest novel therapeutic targets.This metabolomic dataset can serve as a useful public resource to promote precision treatment of TNBC. | Yi Xiao Ding Ma Yun-Song Yang Fan Yang Jia-Han Ding Yue Gong Lin Jiang Li-Ping Ge Song-Yang Wu Qiang Yu Qing Zhang François Bertucci Qiuzhuang Sun Xin Hu Da-Qiang Li Zhi-Ming Shao Yi-Zhou Jiang | 2022 | Cell Research2022，32，5： | 18 |
| 10 | Effects of buried penis on the structure and function of corpus cavernosum in a rat model显示文摘 | CHENG Fan YU Wei-min XIA Yue ZHANG Xiao-bin YANG Si-xing GE Ming-huan | 2010 | Chinese Medical Journal2010，，13： | 17 |
| 11 | Particle size distribution and characteristics of polycyclic aromatic hydrocarbons during a heavy haze episode in Nanjing,China显示文摘A heavy haze episode caused by agricultural burning occurred in Nanjing from November 7 to November8,2009.PM_(10) samples were collected on normal and hazy days from November 1 to November 14,2009 at both city and suburban sites of Nanjing.Sixteen PAHs were measured during the day and at night.The results show that the concentrations of the particles were as high as 579.55 and 573.43 μg/m^3 during the haze episode at the city and suburban sites,respectively,3-4 times higher than those on a normal day.The proportions of fine particles during the haze episode were also higher than those on a normal day.The changes in the concentrations of PAHs were in accordance with the concentrations of the particles.Highmolecular-weight PAHs composed approximately 80% of the total PAHs on normal days and during the haze episode.The concentration of PAHs in fine fractions significantly increased during the haze episode,and this increase was most obvious at night at the city site.The proportion of total carcinogenic PAHs in fine particles was relatively high during the haze episode at both sampling sites,particularly at night at the city site. | Qingzi Meng Shuxian Fan Jiabao He Jian Zhang Yu Sun Yue Zhang Fan Zu | 2015 | Particuology2015，13，1： | 16 |
| 12 | Combined transjugular intrahepatic portosystemic shunt and other interventions for hepatocellular carcinoma with portal hypertension显示文摘AIM: To evaluate combination transjugular intrahepatic portosystemic shunt(TIPS) and other interventions for hepatocellular carcinoma(HCC) and portal hypertension.METHODS: Two hundred and sixty-one patients with HCC and portal hypertension underwent TIPS combined with other interventional treatments(transarterial chemoembolization/transarterial embolization,radiofrequency ablation,hepatic arterio-portal fistulas embolization,and splenic artery embolization) from January 1997 to January 2010 at Beijing Shijitan Hospital. Two hundred and nine patients(121 male and 88 female,aged 25-69 years,mean 48.3 ± 12.5 years) with complete clinical data were recruited. We evaluated the safety of the procedure(procedurerelated death and serious complications),change of portal vein pressure before and after TIPS,symptom relief [e.g.,ascites,hydrothorax,esophageal gastricfundus variceal bleeding(EGVB)],cumulative rates of survival,and distributary channel restenosis. The characteristics of the patients surviving ≥ 5 and < 5 years were also analyzed.RESULTS: The portosystemic pressure was decreased from 29.0 ± 4.1 mm Hg before TIPS to 18.1 ± 2.9 mm Hg after TIPS(t = 69.32,P < 0.05). Portosystemic pressure was decreased and portal hypertension symptoms were ameliorated. During the 5 year followup,the total recurrence rate of resistant ascites or hydrothorax was 7.2%(15/209); 36.8%(77/209) for EGVB; and 39.2%(82/209) for hepatic encephalopathy. The cumulative rates of distributary channel restenosis at 1,2,3,4,and 5 years were 17.2%(36/209),29.7%(62/209),36.8%(77/209),45.5%(95/209) and 58.4%(122/209),respectively. No procedure-related deaths and serious complications(e.g.,abdominal bleeding,hepatic failure,and distant metastasis) occurred. Moreover,Child-Pugh score,portal vein tumor thrombosis,lesion diameter,hepatic arterio-portal fistulas,HCC diagnosed before or after TIPS,stent type,hepatic encephalopathy,and type of other interventional treatments were related to 5 year survival after comparing patient characteristics.CONCLUSION: TIPS combined with other interventional treatments seems to be safe and efficacious in patients with HCC and portal hypertension. | Bin Qiu Meng-Fei Zhao Zhen-Dong Yue Hong-Wei Zhao Lei Wang Zhen-Hua Fan Fu-Liang He Shan Dai Jian-Nan Yao Fu-Quan Liu | 2015 | World Journal of Gastroenterology2015，21，43： | 16 |
| 13 | Analysis on MAV/UAV cooperative combat based on complex network显示文摘A formation model of manned/unmanned aerial vehicle(MAV/UAV) collaborative combat can qualitatively and quantitatively analyze the synergistic effects.However,there is currently no effective and appropriate model construction method or theory,and research in the field of collaborative capability evaluation is basically nonexistent.According to the actual conditions of cooperative operations,a new MAV/UAV collaborative combat network model construction method based on a complex network is presented.By analyzing the characteristic parameters of the abstract network,the index system and complex network are combined.Then,a method for evaluating the synergistic effect of the cooperative combat network is developed.This method provides assistance for the verification and evaluation of MAV/UAV collaborative combat. | Jie-ru Fan Dong-guang Li Ru-peng Li Yue Wang | 2020 | Defence Technology(防务技术)2020，16，1： | 16 |
| 14 | Hierarchy modeling of subsurface palaeochannel reservoir architecture显示文摘The studies on fluvial reservoir architecture are mainly aimed at outcrop and modern deposition,but rarely at the subsurface reservoir,so there are few effective methods to predict the distribution of subsurface reservoir architectures. In this paper,taking the meandering river reservoir of Guantao formation Gudao Oilfield,Jiyang depression,Baohai Gulf Basin,East China as an example,the archi-tectural modeling method of complex meandering belt reservoir is proposed,that is hierarchy con-straint,pattern fitting and multi-dimensional interaction. Architectures of meandering river reservoir can be divided into three hierarchies: meandering channel sandbody,point bar and lateral accretion body. Different hierarchies of the quantitative architecture pattern are fitted to subsurface well data (including dynamic monitoring data) in different hierarchies through one-dimensional hole,2D profiles and plane and 3D space,which are verified by each other. And then 3D model in different hierarchies is established. At the same time,the quantificational relationship between width of active river and the scale of point bar is set up,and the scale of lateral accretion sand body and shale beddings is con-firmed with horizontal well data. The study not only has significant meaning on the development of geology,but also can improve the oilfield exploitation greatly. | WU ShengHe1,YUE DaLi1,LIU JianMin2,SHU QingLin2,FAN Zheng1,3 & LI YuPeng1 1 Earth Sciences and Geoinformatics School,China University of Petroleum,Beijing 102249,China 2 SINOPEC Shengli Oilfield Co. Ltd.,Dongying 257000,China 3 Beijing Telon High-tech Corporation,Beijing 100085,China | 2008 | Science China Earth Sciences2008，51，S2： | 15 |
| 15 | The Chromosome-Based Rubber Tree Genome Provides New Insights into Spurge Genome Evolution and Rubber Biosynthesis显示文摘The rubber tree,Hevea brasiliensis,produces natural rubber that serves as an essential industrial raw material.Here,we present a high-quality reference genome for a rubber tree cultivar GT1 using single-molecule real-time sequencing(SMRT)and Hi-C technologies to anchor the~1.47-Gb genome assembly into 18 pseudochromosomes.The chromosome-based genome analysis enabled us to establish a model of spurge chromosome evolution,since the common paleopolyploid event occurred before the split of Hevea and Manihot.We show recent and rapid bursts of the three Hevea-specific LTR-retrotransposon families during the last 10 million years,leading to the massive expansion by~65.88%(~970 Mbp)of the whole rubber tree genome since the divergence from Manihot.We identify large-scale expansion of genes associated with whole rubber biosynthesis processes,such as basal metabolic processes,ethylene biosynthesis,and the activation of polysaccharide and glycoprotein lectin,which are important properties for latex production.A map of genomic variation between the cultivated and wild rubber trees was obtained,which contains~15.7 million high-quality single-nucleotide polymorphisms.We identified hundreds of candidate domestication genes with drastically lowered genomic diversity in the cultivated but not wild rubber trees despite a relatively short domestication history of rubber tree,some of which are involved in rubber biosynthesis.This genome assembly represents key resources for future rubber tree research and breeding,providing novel targets for improving plant biotic and abiotic tolerance and rubber production. | Jin Liu Cong Shi Cheng-Cheng Shi Wei Li Qun-Jie Zhang Yun Zhang Kui Li Hui-Fang Lu Chao Shi Si-Tao Zhu Zai-Yun Xiao Hong Nan Yao Yue Xun-Ge Zhu Yu Wu Xiao-Ning Hong Guang-Yi Fan Yan Tong Dan Zhang Chang-Li Mao Yun-Long Liu Shi-Jie Hao Wei-Qing Liu Mei-Qi Lv Hai-Bin Zhang Yuan Liu Ge-Ran Hu-tang Jin-Peng Wang Jia-Hao Wang Ying-Huai Sun Shu-Bang Ni Wen-Bin Chen Xing-Cai Zhang Yuan-Nian Jiao Evan E.Eichler Guo-Hua Li Xin Liu Li-Zhi Gao | 2020 | Molecular Plant2020，13，2： | 15 |
| 16 | Branched aliphatic alkanes of shell bar section in Qarhan Lake,Qaidam Basin and their paleoclimate significance显示文摘Biomarkers of paleolake deposits from Qarhan Salt Lake in Qaidam Basin,northwest China were sys-tematically analyzed and the A―C series compounds of branched aliphatic alkanes with quaternary substituted carbon atom(BAQCs) were identified. The homologous distinguished three series,A―C,were identified as 5,5-diethylalkanes,6,6-diethylalkanes and 5-butyl,5-ethylalkanes series,and their relative abundance was A > B > C. Series A and C were characterized by odd carbon numbers,whereas series B was characterized by even carbon numbers. The high values of series A corresponded with the high values of series B and C. Therefore,it can be concluded that series A,B and C possess a similar biological origin. The abundance of series A was relatively low in the lower part of the section compared with that in the upper part,implying that these series originated from bacteria and/or algae more prevalent in fresh-mesohaline water,and such kinds of bacteria and/or algae are most likely to be thermophilous species. The A25/nC25 ratio differences in the section show that such branched aliphatic alkanes can be treated as one kind of environmental change proxy for paleolake evolution and may provide important information for the climate reconstruction of the Late Pleistocene. | ZHANG HuCai CHANG FengQin LI Bin LEI GuoLiang CHEN Yue ZHANG WenXiang NIU Jie FAN HongFang YANG MingSheng | 2007 | Chinese Science Bulletin2007，52，9： | 13 |
| 17 | Impact of Cardiovascular Disease Deaths on Life Expectancy in Chinese Population显示文摘Objective We aimed to analyze the impact of cardiovascular disease(CVD) deaths on life expectancy(LE) in Chinese population and estimate the percentage reduction in CVD mortality needed to increase LE by 1 year from the current level, a national target of health improvement. Methods We used life tables, cause-elimination life tables, and age decomposition of LE with corrected mortality data from the National Disease Surveillance System in 2010. Results LE at birth of Chinese people was 73.24 years in 2010. Women had a longer LE than men, and urban population had a longer LE than rural population. CVD deaths resulted in a 4.79-year LE loss and premature deaths in people aged 25 to 64 years were responsible for a substantial part of LE loss from CVD. Death from ischemic heart disease and cerebrovascular diseases accounted for 69.2% of LE loss from CVD deaths and death from cerebrovascular diseases was the largest contributor. In rural men, 51.1% LE loss from CVD deaths was caused by cerebrovascular diseases. If there were no changes in mortality rates for all other diseases, a 27.4% reduction in CVD mortality would increase LE by 1 year in Chinese population. Conclusion There is a considerable impact of CVD deaths on LE. A 1-year LE increase in the future requires at least a 27.4% reduction in CVD mortality from the current level. Targeting the rural population and tackling cerebrovascular diseases are important for reaching the national goal of health improvement. | FAN Jie LI Guo Qi LIU Jing WANG Wei WANG Miao QI Yue XIE Wu Xiang LIU Jun ZHAO Fan LI Yan ZHAO Dong | 2014 | Biomedical and Environmental Sciences2014，27，3： | 13 |
| 18 | Defecation function and quality of life in patients with slow-transit constipation after colectomy显示文摘BACKGROUND Although total or subtotal colectomy for slow-transit constipation(STC)has been proven to be a definite treatment,the associated defecation function and quality of life(QOL)are rarely studied.AIM To evaluate the effectiveness of surgery for STC regarding defecation function and QOL.METHODS From March 2013 to September 2017,30 patients undergoing surgery for STC in our department were analyzed.Preoperative,intra-operative,and postoperative 3-mo,6-mo,1-year,and 2-year follow-up details were recorded.Defecation function was assessed by bowel movements,abdominal pain,bloating,straining,laxative,enema use,diarrhea,and the Wexner constipation and incontinence scales.QOL was evaluated using the gastrointestinal QOL index and the 36-item short form survey.RESULTS The majority of patients(93.1%,27/29)stated that they benefited from the operation at the 2-year follow-up.At each time point of the follow-up,the number of bowel movements per week significantly increased compared with that of the preoperative conditions(P<0.05).Similarly,compared with the preoperative values,a marked decline was observed in bloating,straining,laxative,and enema use at each time point of the follow-up(P<0.05).Postoperative diarrhea could be controlled effectively and notably improved at the 2-year follow-up.The Wexner incontinence scores at 6-mo,1-year,and 2-year were notably lower than those at the 3-mo follow-up(P<0.05).Compared with those of the preoperative findings,the Wexner constipation scores significantly decreased following surgery(P<0.05).Thus,it was reasonable to find that the gastrointestinal QOL index scores clearly increase(P<0.05)and that the 36-item short form survey results displayed considerable improvements in six spheres(role physical,role emotional,physical pain,vitality,mental health,and general health)following surgery.CONCLUSION Total or subtotal colectomy for STC is not only effective in alleviating constipation-related symptoms but also in enhancing patients’QOL. | Yue Tian Li Wang Jing-Wang Ye Yong Zhang Hui-Chao Zheng Hao-De Shen Fan Li Bao-Hua Liu Wei-Dong Tong | 2020 | World Journal of Clinical Cases2020，8，10： | 13 |
| 19 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 20 | Olfactory ecto-mesenchymal stem cell-derived exosomes ameliorate murine Sjögren’s syndrome by modulating the function of myeloid-derived suppressor cells显示文摘Sjögren’s syndrome(SS)is a systemic autoimmune disease characterized by progressive inflammation and tissue damage in salivary glands and lacrimal glands.Our previous studies showed that myeloid-derived suppressor cells(MDSCs)exhibited impaired immunosuppressive function during disease progression in patients with SS and mice with experimental Sjögren’s syndrome(ESS),but it remains unclear whether restoring the function of MDSCs can effectively ameliorate the development of ESS.In this study,we found that murine olfactory ecto-mesenchymal stem cell-derived exosomes(OE-MSC-Exos)significantly enhanced the suppressive function of MDSCs by upregulating arginase expression and increasing ROS and NO levels.Moreover,treatment with OE-MSC-Exos via intravenous injection markedly attenuated disease progression and restored MDSC function in ESS mice.Mechanistically,OE-MSC-Exo-secreted IL-6 activated the Jak2/Stat3 pathway in MDSCs.In addition,the abundant S100A4 in OE-MSC-Exos acted as a key factor in mediating the endogenous production of IL-6 by MDSCs via TLR4 signaling,indicating an autocrine pathway of MDSC functional modulation by IL-6.Taken together,our results demonstrated that OE-MSC-Exos possess therapeutic potential to attenuate ESS progression by enhancing the immunosuppressive function of MDSCs,possibly constituting a new strategy for the treatment of Sjögren’s syndrome and other autoimmune diseases. | Ke Rui Yue Hong Qiugang Zhu Xiaofei Shi Fan Xiao Hailong Fu Qing Yin Yida Xing Xinfeng Wu Xiaodan Kong Huaxi Xu Jie Tian Shengjun Wang Liwei Lu | 2021 | Cellular & Molecular Immunology2021，18，2： | 12 |
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