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| 1 | De novo assembly of a Chinese soybean genome显示文摘Soybean was domesticated in China and has become one of the most important oilseed crops. Due to bottlenecks in their introduction and dissemination, soybeans from different geographic areas exhibit extensive genetic diversity. Asia is the largest soybean market; therefore, a high-quality soybean reference genome from this area is critical for soybean research and breeding.Here, we report the de novo assembly and sequence analysis of a Chinese soybean genome for 'Zhonghuang 13' by a combination of SMRT, Hi-C and optical mapping data. The assembled genome size is 1.025 Gb with a contig N50 of 3.46 Mb and a scaffold N50 of 51.87 Mb. Comparisons between this genome and the previously reported reference genome(cv. Williams82) uncovered more than 250,000 structure variations. A total of 52,051 protein coding genes and 36,429 transposable elements were annotated for this genome, and a gene co-expression network including 39,967 genes was also established. This high quality Chinese soybean genome and its sequence analysis will provide valuable information for soybean improvement in the future. | Yanting Shen Jing Liu Haiying Geng Jixiang Zhang Yucheng Liu Haikuan Zhang Shilai Xing Jianchang Du Shisong Ma Zhixi Tian | 2018 | Science China(Life Sciences)2018，61，8： | 11 |
| 2 | Distribution characteristics of poly-and perfluoroalkyl substances in the Yangtze River Delta显示文摘In this work, a method was developed and optimized for the analysis of polyfluoroalkyl and/or perfluoroalkyl substances(PFASs) content in surface water and sediment samples with high instrumental response and good separation. Surface water and sediment samples were collected from the Yangtze River Delta(YRD) to analyze the distribution characteristics of perfluoroalkyl carboxylic acids(PFCAs), perfluoroalkane sulfonic acids(PFSAs), perfluoroalkyl phosphonic acids(PFPAs), perfluoroalkyl phosphinic acids(PFPiAs), and polyfluoroalkyl phosphoric acid diesters(di PAPs). The results showed that the total concentrations of PFCAs and PFSAs in YRD varied from 31 to 902 ng/L. PFCAs(≥ 11 carbons) and PFSAs(≥ 10 carbons atoms) were not detected in any surface water samples. The mean concentrations of all PFCAs and PFSAs in surface water from the sampling areas decreased in the following order:Yangtze river(191 ng/L) ≈ Taihu lake(189 ng/L) > Huangpu river(122 ng/L) ≈ Qiantang river(120 ng/L) > Jiaxing urban river(100 ng/L). Strong significant(p < 0.05) correlations between the concentrations of many of the compounds were found in the sampling areas, suggesting a common source for these compounds. Only perfluorooctanoic acid(PFOA) was observed in all sediment samples, at concentrations varying from 0.02 to 1.35 ng/g. Finally, detection rates of two di PAPs were only 8% and 10%, respectively and the concentration of di PAPs was two to three times lower compared to PFCAs and PFSAs. | Binghui Zheng Xiaolei Liu Rui Guo Qing Fu Xingru Zhao Shanjun Wang Sheng Chang Xing Wang Mengjiao Geng Guang Yang | 2017 | Journal of Environmental Sciences2017，29，11： | 8 |
| 3 | System modeling based measurement error analysis of digital sun sensors显示文摘Stringent attitude determination accuracy is required for the development of the advanced space technologies and thus the accuracy improvement of digital sun sensors is necessary.In this paper,we presented a proposal for measurement error analysis of a digital sun sensor.A system modeling including three different error sources was built and employed for system error analysis.Numerical simulations were also conducted to study the measurement error introduced by different sources of error.Based on our model and study,the system errors from different error sources are coupled and the system calibration should be elaborately designed to realize a digital sun sensor with extra-high accuracy. | WEI M insong XING Fei WANG Geng YOU Zheng | 2015 | Instrumentation2015，2，1： | 7 |
| 4 | Safety and feasibility of transulnar versus transradial artery approach for coronary catheterization in non-selective patients显示文摘 | Geng Wei Fu Xianghua Gu Xinshun Jiang Yunfa Fan Weize Wang Yanbo Li Wei Xing Kun Liu Chen | 2014 | Chinese Medical Journal2014，，7： | 5 |
| 5 | Serum macrophage migration inhibitory factor as a potential biomarker to evaluate therapeutic response in patients with allergic asthma:an exploratory study显示文摘Background:Previous studies have shown that macrophage migration inhibitory factor(MIF)is involved in the pathogenesis of asthma.This study aimed to investigate whether serum MIF reflects a therapeutic response in allergic asthma.Methods:We enrolled 30 asthmatic patients with mild-to-moderate exacerbations and 20 healthy controls,analyzing the parameter levels of serum MIF,serum total immunoglobulin E(tIgE),peripheral blood eosinophil percentage(EOS%),and fractional exhaled nitric oxide(FeNO).Lung function indices were used to identify disease severity and therapeutic response.Results:Our study showed that all measured parameters in patients were at higher levels than those of controls.After one week of treatment,most parameter levels decreased significantly except for serum tIgE.Furthermore,we found that serum MIF positively correlated with EOS%as well as FeNO,but negatively correlated with lung function indices.Receiver operator characteristic(ROC)curve analysis indicated that among the parameters,serum MIF exhibited a higher capacity to evaluate therapeutic response.The area under the curve(AUC)of MIF was 0.931,with a sensitivity of 0.967 and a specificity of 0.800.Conclusions:Our results suggested that serum MIF may serve as a potential biomarker for evaluating therapeutic response in allergic asthma with mild-to-moderate exacerbations. | Huiyuan ZHU Shaochun YAN Jingshuo WU Zhong ZHANG Xiaolin LI Zheng LIU Xing MA Lina ZHOU Lin ZHANG Mingming FENG Yiwei GENG Aixin ZHANG Sabina JANCIAUSKIENE Aiguo XU | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，6： | 3 |
| 6 | First experimental constraints on WIMP couplings in the effective field theory framework from CDEX显示文摘We present weakly interacting massive particles(WIMPs) search results performed using two approaches of effective field theory from the China Dark Matter Experiment(CDEX), based on the data from both CDEX-1B and CDEX-10 stages. In the nonrelativistic effective field theory approach, both time-integrated and annual modulation analyses were used to set new limits for the coupling of WIMP-nucleon effective operators at 90% confidence level(C.L.) and improve over the current bounds in the low mχregion. In the chiral effective field theory approach, data from CDEX-10 were used to set an upper limit on WIMP-pion coupling at 90% C.L. We for the first time extended the limit to the m_(χ)<6 GeV/c^(2) region. | Yi Wang Zhi Zeng Qian Yue LiTao Yang KeJun Kang YuanJing Li Mehment Agartioglu HaiPeng An JianPing Chang JingHan Chen YunHua Chen JianPing Cheng Cheng Yi Chiang WenHan Dai Zhi Deng ChangHao Fang XinPing Geng Hui Gong QiuJu Guo XuYuan Guo HongJian He Li He ShengMing He JinWei Hu TuChen Huang HanXiong Huang HaiTao Jia LiPing Jia Xi Jiang HauBin Li JianMin Li Jin Li MingXuan Li RenMingJie Li Xia Li YuLan Li Bin Liao FongKay Lin ShinTed Lin ShuKui Liu YanDong Liu Yu Liu YuanYuan Liu ZhongZhi Liu Hao Ma YuCai Mao QiYuan Nie JinHua Ning Hui Pan NingChun Qi Jie Ren XiChao Ruan ChangSong Shang Vivek Sharma Ze She Lakhwinder Singh Monoj Kumar Singh TianXi Sun ChangJian Tang WeiYou Tang Yang Tian GuangFu Wang Li Wang Qing Wang Yu Chen Wang YunXiang Wang Zhen Wang Henry Tsz-King Wong ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue YuLu Yan Nan Yi ChunXu Yu HaiJun Yu JianFeng Yue Ming Zeng BingTao Zhang Lei Zhang FengShou Zhang ZhenYu Zhang KangKang Zhao MingGang Zhao JiFang Zhou ZuYing Zhou JingJun Zhu | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，8： | 3 |
| 7 | Electrostatic-lenses position-sensitive TOF MCP detector for beam diagnostics and new scheme for mass measurements at HIAF显示文摘A foil–microchannel plate(MCP)detector,which uses electrostatic lenses and possesses both good position and timing resolutions,has been designed and simulated for beam diagnostics and mass measurements at the next-generation heavy-ion-beam facility HIAF in China.Characterized by low energy loss and good performances of timing and position measurements,it would be located at focal planes in fragment separator HFRS for position monitoring,beam turning,Bq measurement,and trajectory reconstruction.Moreover,it will benefit the building-up of a magnetic-rigidity–energy-loss–time-offlight(BqDETOF)method at HFRS for high-precision in-flight particle identification of radioactive isotope beams on an event-by-event basis.Most importantly,the detector can be utilized for in-ring TOF and position measurements,beam-line TOF measurements at two achromatic foci,and position measurements at a dispersive focus of HFRS,thus making it possible to use two complementary mass measurement methods[isochronous mass spectrometry at the storage ring SRing and magnetic-rigidity–time-of-flight(BqTOF)at the beam-line HFRS]in one single experimental run. | Jun-Hao Liu Zhuang Ge Qian Wang Geng Wang Li-Na Sheng Wen-Wen Ge Xing Xu Peng Shuai Qi Zeng Bo Wu | 2019 | Nuclear Science and Techniques2019，30，10： | 3 |
| 8 | Occupational Carbon Monoxide Poisoning Associated with Diesel Motor Operation in an Air-raid Shelter in June 2015, Jinan City, China-An Epidemiological Investigation显示文摘Occupational carbon monoxide(CO) poisoning related to diesel motor fumes in an air-raid shelter(ARS) was first identified in Jinan City,China,in June 2015.A total of 17 cases were identified,including 14 possible cases of firemen and 3 confirmed cases of water channel clean-up workers.The overall attack rate(AR) of firemen was 42%(14/33).The firemen had a significantly higher AR with a longer exposure and more protracted time of rescue in the ARS(P<0.05).All the cases stated that they did not realize the potentially high level of exposure to CO in the ARS.CO poisoning posed a risk to both patients and service providers.Occupational safety and health education should be promoted and enforced in all workplaces where CO sources exist. | CUI Liang Liang ZHOU Jing Wen GENG Xing Yi LI Xin Wei LIU Zhong George A.Conway ZHANG Ji | 2017 | Biomedical and Environmental Sciences2017，30，10： | 3 |
| 9 | Determination of thickness of wax deposition in oil pipelines using gamma-ray transmission method显示文摘Wax deposition in pipelines is a crucial problem in the oil industry.An approach that combines the gammaray transmission method with scanning technology is proposed to detect the thickness of wax deposition.The performance of the method is validated through simulations with MCNP code.An experiment is also carried out with a 300 mCi ^(137)Cs source and a LaBr_3 detector.A good correspondence is observed between the simulation and experimental results.The results indicate that the approach is efficient for detecting the thickness of wax deposition in oil pipelines. | Can Cheng Wen-Bao Jia Da-Qian Hei Shu-Qun Geng Hong-Tao Wang Li-Teng Xing | 2018 | Nuclear Science and Techniques2018，29，8： | 2 |
| 10 | Association between Nonalcoholic Fatty Liver Disease and Carotid Artery Disease in a Community-Based Chinese Population: A Cross-Sectional Study显示文摘 | Yu-Chen Guo Yong Zhou Xing Gao Yan Yao Bin Geng Qing-Hua Cui Ji-Chun Yang Hong-Pu Hu | 2018 | Chinese Medical Journal2018，，19： | 2 |
| 11 | Multifunctional microcapsules:A theranostic agent for US/MR/PAT multi-modality imaging and synergistic chemo-photothermal osteosarcoma therapy显示文摘Development of versatile theranostic agents that simultaneously integrate therapeutic and diagnostic features remains a clinical urgent.Herein,we aimed to prepare uniform PEGylated(lactic-co-glycolic acid)(PLGA)microcapsules(PB@(Fe_(3)O_(4)@PEG-PLGA)MCs)with superparamagnetic Fe3O4 nanoparticles embedded in the shell and Prussian blue(PB)NPs inbuilt in the cavity via a premix membrane emulsification(PME)method.On account of the eligible geometry and multiple load capacity,these MCs could be used as efficient multi-modality contrast agents to simultaneously enhance the contrasts of US,MR and PAT imaging.In-built PB NPs furnished the MCs with excellent photothermal conversion property and embedded Fe_(3)O_(4)NPs endowed the magnetic location for fabrication of targeted drug delivery system.Notably,after further in-situ encapsulation of antitumor drug of DOX,(PB+DOX)@(Fe_(3)O_(4)@PEG-PLGA)MCs possessed more unique advantages on achieving near infrared(NIR)-responsive drug delivery and magnetic-guided chemo-photothermal synergistic osteosarcoma therapy.In vitro and in vivo studies revealed these biocompatible(PB+DOX)@(Fe_(3)O_(4)@PEG-PLGA)MCs could effectively target to the tumor tissue with superior therapeutic effect against the invasion of osteosarcoma and alleviation of osteolytic lesions,which will be developed as a smart platform integrating multi-modality imaging capabilities and synergistic effect with high therapy efficacy. | Hufei Wang Sijia Xu Daoyang Fan Xiaowen Geng Guang Zhi Decheng Wu Hong Shen Fei Yang Xiao Zhou Xing Wang | 2022 | Bioactive Materials2022，7，1： | 2 |
| 12 | Is tuberculosis patients management improved in the integrated TB control model in West China?A survey in Guizhou Province,China显示文摘Background:Tuberculosis(TB)patient management(TPM)is crucial to improve patient compliance to treatment.The coverage of TPM delivered by TB dispensaries or Centers for Disease Control and Prevention(CDC)was not high under the previous CDC model of TB control in China.In the integrated TB control model in China,TB patient management(TPM)was mainly delivered by lay health workers(LHWs)in primary health care(PHC)sectors.This study aims to investigate TPM delivery in resource-limited western China and to identify factors affecting TPM delivery by LHWs under the integrated TB control model.Methods:A stratified random sampling was used to select study sites.Pulmonary TB(PTB)patients≥15 years old from selected counties/districts in Guizhou Province were surveyed from August 2015 to May 2016.Structured questionnaires were used to collect data.Aχ^2 test and logistic regression were used to identify factors associated with self-administered treatment(non-TPM).Results:In total,638 PTB patients were included in the final analysis.Close to 30%of patients were ethnic minorities.More than 30%of patients were from counties with high TB burden,and 24.9%of patients had poor compliance to treatment.Only 37.1%of patients received TPM delivered by LHWs under the integrated TB control model throughout the treatment period.The main reasons for unwillingness to manage reported by patients included social stigma and no perceived need.Being ethnic minorities(OR=3.35)was a main factor associated with lower likelihood of receiving TPM,while living in areas with middle or high TB burden may increase the likelihood of receiving TPM(OR=0.17 and 0.25,respectively).Among current management approaches,more than 85%of patients chose phone reminder as their preferred TPM by LHWs.Conclusions:TPM under the integrated model in West China is still low and need further improvement,and the impeding factors of TPM need to be addressed.Strengthening patient-centered and community-based TPM and developing more feasible approaches of TPM delivery should be explored in future research in this region. | Jie Pu Wei Chen Wei-Xi Jiang Wei Xing Sheng-Xiang Liang Geng Wang Shi-Li Liu Hao Wu Ying Li Sheng-Lan Tang | 2019 | Infectious Diseases of Poverty2019，8，4： | 2 |
| 13 | Yhhu3813 is a novel selective inhibitor of c-Met kinase that inhibits c-Met-dependent neoplastic phenotypes of human cancer cells显示文摘 | Chang-xi HE Jing AI Wei-qiang XING Yi CHEN Hao-tian ZHANG Min HUANG You-hong HU Jian DING Mei-yu GENG | 2014 | Acta Pharmacologica Sinica2014，35，1： | 2 |
| 14 | Geant4 analysis and optimization of a double crystal phoswich detector for beta–gamma coincidence detection显示文摘In this study, a novel phoswich detector for beta–gamma coincidence detection is designed. Unlike the triple crystal phoswich detector designed by researchers at the University of Missouri, Columbia, this phoswich detector is of the semi-well type, so it has a higher detection efficiency. The detector consists of BC-400 and NaI:Tl with decay time constants of 2.4 and 230 ns, respectively.The BC-400 scintillator detects beta particles, and the Na I:Tl cell is used for gamma detection. Geant4 simulations of this phoswich detector find that a 2-mm-thick BC-400 scintillator can absorb nearly all of the beta particles whose energies are below 700 keV. Further, for a 2.00-cmthick NaI:Tl crystal, the gamma source peak efficiency for photons ranges from a maximum of nearly 90% at 30 keV to 10% at 1 MeV. The self-absorption effect is also discussed in this paper in order to determine the carrier gas' s influence. | Xing Fan Xian-Peng Zhang Geng Tian Chao-Wen Yang | 2018 | Nuclear Science and Techniques2018，29，4： | 2 |
| 15 | RNA-binding protein QKI regulates contact inhibition via Yes-associate protein in ccRCC显示文摘Contact inhibition adjusts organ size to the proper size and ensures the cultured cells growing to a monolayer.By regulating the downstream coordinator YAP,the evolutionarily conserved Hippo transduction pathway attunes cell growth and death in response to cell contact inhibition,polarity,self-renewal,and differentiation.Dysregulation of this pathway is involved in various diseases such as cancer.RNA-binding protein QKI regulates cell proliferation,metabolism,division,and immunity in various cancer models,but its role in cancer cell contact inhibition remains unclear.In this study,we aimed to clarify the relationship between QKI and YAP,and the role of their interaction in cell contact inhibition.We found a lower QKI expression level in sparse condition,whereas a higher expression level in confluent condition by western blot analysis and immunofluorescence assay.QKI knockdown elevated cell proliferation and invasion both in vitro and in vivo.Strikingly,the results of CCK-8 assay,colony formation assay,and transwell assay showed that the phenomenon was in accord with the expression level of pYAP and reverse with YAP.Higher levels of Wnt3a and β-catenin were also found in xenografts of QKI-knockdown clear cell renal cell carcinoma (ccRCC) CAKI-1 cells by western blot analysis and immumohistochemical staining.Finally,a positive correlation between QKI and pYAP was found in clinical specimens by immunohistochemistry.Thus,as a negative regulator of YAP,QKI attuned the cell contact inhibition,leading to inhibition of cancer cell proliferation and invasion through Wnt and GPCR pathway. | Zheng Zhu Di Wei Xi'an Li Fuli Wang Fei Yan Zibao Xing Zhao Yan Huanyu Lu Dongsheng Zhai Ziehen Ye Geng Zhang Ping Meng Yu Zheng Jiarui Yuan Zifan Lu Jianlin Yuan | 2019 | Acta Biochimica et Biophysica Sinica2019，51，1： | 2 |
| 16 | Effect of anaerobic reaction time on denitrifying phosphorus removal and N 2 O production显示文摘 | Yayi Wang Junjun Geng Zhongjia Ren Weitao He Meiyan Xing Min Wu Shaowei Chen | 2011 | Bioresource Technology2011，，10： | 1 |
| 17 | A New Hierarchy Soliton Equations Associated with a Schrdinger Type Spectral Problem and the Corresponding Finite-dimensional Integrable System显示文摘By introducing a Schrodinger type spectral problem with four potentials, we derive a new hierarchy nonlinear evolution equations. Through the nonlinearization of eigenvalue problems, we get a new finite-dimensional Hamiltonian system, which is completely integrable in the Liouville sense. | XING Xiu-zhi WU Jing-zhu GENG Xian-guo | 2006 | Chinese Quarterly Journal of Mathematics2006，21，2： | 1 |
| 18 | Thio glucose bound gold nanoparticles enhance radio-eytotoxic targeting of ovarian can- cer显示文摘 | GENG F SONG K XING J Z | 2011 | Nanotechnology2011，22，28： | 1 |
| 19 | A new method to culture primary neural stem cells of embryonic rats显示文摘 | Xing CM Geng XL Liu YX | | 0，，： | 1 |
| 20 | Electronic spectra of the linear polyyne cations HC2n H^+ (n = 2-8): An ab initio study 显示文摘 | ZHANG Jing Lai GUO Xu Geng CAO Ze Xing | 2009 | J Chem Phys2009，131，14： | 1 |
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