|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Petrogenesis of Late Cretaceous Jiangla'angzong I-Type Granite in Central Lhasa Terrane, Tibet, China: Constraints from Whole-Rock Geochemistry, Zircon U-Pb Geochronology, and Sr-Nd-Pb-Hf Isotopes显示文摘The Jiangla'angzong granite in the northern part of the Central Lhasa Terrane is composed of syenogranite and adamellite. LA-ICP-MS zircon U-Pb analyses suggest that syenogranite has a weighted mean ^(206) Pb/^(238) U age of 86±1 Ma(mean square weighted deviation=0.37), which is in accordance with the muscovite Ar-Ar age(85±1 Ma) of Cu-Au ore-bearing skarns and the zircon U-Pb age(84±1 Ma) of adamellite. This suggests that the Jiangla'angzong magmatism and Cu–Au mineralization events took place during the Late Cretaceous. The granite contains hornblende, biotite, and pyroxene, and does not contain Al-bearing minerals, such as muscovite, cordierite, and garnet. It has high contents of SiO_2(65.10–70.91 wt%), K_2O(3.44–5.17 wt%), and total K_2O+Na_2O(7.13–8.15 wt%), and moderate contents of A_(12)O_3(14.14–16.45 wt%) and CaO(2.33–4.11 wt%), with a Reitman index(σ43) of 2.18 to 2.33, and A/CNK values of 0.88 to 1.02. The P_2O_5 contents show a negative correlation with SiO_2, whereas Pb contents show a positive correlation with SiO_2. Th and Y contents are relatively low and show a negative correlation with the Rb contents. These characteristics suggest that the Jiangla'angzong granite is a high K calc–alkaline metaluminous I–type granite. It is enriched in light rare earth elements(LREE) and large ion lithofile elements(LILE), and depleted in heavy rare earth elements(HREE) and high field strength elements(HFSE), with LREE/HREE ratios of 11.7 to 18.1. The granite has negative Eu anomalies of 0.58 to 0.94 without obvious Ce anomalies(δCe=1.00–1.04). The relatively low initial 87 Sr/86 Sr ratios of 0.7106 to 0.7179, positive εHf(t) values of 1.0 to 4.1, and two-stage Hf model ages(TDM2) ranging from 889 Ma to 1082 Ma, These geochemical features indicate that the granite derived from a juvenile crust. The(^(143) Nd/^(144) Nd)_t values from the Jiangla'angzong granite range from 0.5121 to 0.5123, its εNd(t) values range from-10.17 to-6.10, its(^(206) Pb/^(204) Pb)_t values range from 18.683 to 18.746, its(^(207) Pb/^(204) Pb)_t values range from 15.695 to 15.700, and its(^(208) Pb/^(204) Pb)_t values range from 39.012 to 39.071. These data indicate that the granite was formed by melting of the upper crust with the addition of some mantle materials. We propose that the Jiangla'angzong granite was formed during the postcollision extension of the Qiangtang and Lhasa terranes. | LIU Hong LI Guangming HUANG Hanxiao CAO Huawen YUAN Qian LI Yingxu OUYANG Yuan LAN Shuangshuang LU Menghong YAN Guoqiang | 2018 | Acta Geologica Sinica(English Edition)2018，92，4： | 20 |
| 2 | Role of AMPK in atherosclerosis via autophagy regulation显示文摘Atherosclerosis is characterized by the accumulation of lipids and deposition of fibrous elements in the vascular wall, which is the primary cause of cardiovascular diseases. Adenosine monophosphate-activated protein kinase(AMPK) is a metabolic sensor of energy metabolism that regulates multiple physiological processes, including lipid and glucose metabolism and the normalization of energy imbalances. Overwhelming evidence indicates that AMPK activation markedly attenuates atherosclerosis development. Autophagy inhibits cell apoptosis and inflammation and promotes cholesterol efflux and efferocytosis. Physiological autophagy is essential for maintaining normal cardiovascular function. Increasing evidence demonstrates that autophagy occurs in developing atherosclerotic plaques. Emerging evidence indicates that AMPK regulates autophagy via a downstream signaling pathway. The complex relationship between AMPK and autophagy has attracted the attention of many researchers because of this close relationship to atherosclerosis development. This review demonstrates the role of AMPK and autophagy in atherosclerosis. An improved understanding of this interrelationship will create novel preventive and therapeutic strategies for atherosclerosis. | Hanxiao Ou Chuhao Liu Wenjie Feng Xinwen Xiao Shengsong Tang Zhongcheng Mo | 2018 | Science China(Life Sciences)2018，61，10： | 8 |
| 3 | Size-Dependent Oxidation-Induced Phase Engineering for MOFs Derivatives Via Spatial Confinement Strategy Toward Enhanced Microwave Absorption显示文摘Precisely reducing the size of metal-organic frameworks(MOFs)derivatives is an effective strategy to manipulate their phase engineering owing to size-dependent oxidation;however,the underlying relationship between the size of derivatives and phase engineering has not been clarified so far.Herein,a spatial confined growth strategy is proposed to encapsulate small-size MOFs derivatives into hollow carbon nanocages.It realizes that the hollow cavity shows a significant spatial confinement effect on the size of confined MOFs crystals and subsequently affects the dielectric polarization due to the phase hybridization with tunable coherent interfaces and heterojunctions owing to size-dependent oxidation motion,yielding to satisfied microwave attenuation with an optimal reflection loss of-50.6 d B and effective bandwidth of 6.6 GHz.Meanwhile,the effect of phase hybridization on dielectric polarization is deeply visualized,and the simulated calculation and electron holograms demonstrate that dielectric polarization is shown to be dominant dissipation mechanism in determining microwave absorption.This spatial confined growth strategy provides a versatile methodology for manipulating the size of MOFs derivatives and the understanding of size-dependent oxidation-induced phase hybridization offers a precise inspiration in optimizing dielectric polarization and microwave attenuation in theory. | Hanxiao Xu Guozheng Zhang Yi Wang Mingqiang Ning Bo Ouyang Yang Zhao Ying Huang Panbo Liu | 2022 | Nano-Micro Letters2022，14，6： | 7 |
| 4 | The m^(6)A methylome of SARS-CoV-2 in host cells显示文摘The newly identified Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2)has resulted in a global health emergency because of its rapid spread and high mortality.The molecular mechanism of interaction between host and viral genomic RNA is yet unclear.We demonstrate herein that SARS-CoV-2 genomic RNA,as well as the negative-sense RNA,is dynamically N6-methyladenosine(m^(6)A)-modified in human and monkey cells.Combined RIP-seq and miCLIP analyses identified a total of 8 m^(6)A sites at single-base resolution in the genome.Especially,epidemic strains with mutations at these identified m^(6)A sites have emerged worldwide,and formed a unique cluster in the US as indicated by phylogenetic analysis.Further functional experiments showed that m^(6)A methylation negatively regulates SARS-CoV-2 infection.SARS-CoV-2 infection also triggered a global increase in host m^(6)A methylome,exhibiting altered localization and motifs of m^(6)A methylation in mRNAs.Altogether,our results identify m^(6)A as a dynamic epitranscriptomic mark mediating the virus–host interaction. | Jun’e Liu Yan-Peng Xu Kai Li Qing Ye Hang-Yu Zhou Hanxiao Sun Xiaoyu Li Liu Yu Yong-Qiang Deng Rui-Ting Li Meng-Li Cheng Bo He Jia Zhou Xiao-Feng Li Aiping Wu Chengqi Yi Cheng-Feng Qin | 2021 | Cell Research2021，31，4： | 5 |
| 5 | Study on the promotion of lymphocytes in patients with COVID-19 by broad-spectrum chemokine receptor inhibitor vMIP-Ⅱ and its Mechanism of signal transmission in vitro显示文摘Dear Editor,COVID-19 cases showed a significant decrease in the number of peripheral CD4^(+) and CD8^(+)T cells accompanied by overactivation of cells.1 HHV8-derived viral macrophage inflammatory protein vMIP-Ⅱ is the only broad-spectrum chemokine receptor inhibitor that binds to three subtribes of chemokine receptors,which can significantly increase the specific cell immune response in infected organisms and have an effect of reducing plasma viral load on the viremia period.24 Here we report the effect of vMIP-Ⅱ in COVID-19. | Shiyu Li Shuting Liu Zhenyou Jiang Lixia Feng Yong Gao Youyu Chen Anding Xu Wenhua Huang Nuofu Zhang Hanxiao Sun | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 5 |
| 6 | Evaluation of human epidermal growth factor receptor 2 status of breast cancer using preoperative multidetector computed tomography with deep learning and handcrafted radiomics features显示文摘Objective:To evaluate the human epidermal growth factor receptor 2(HER2)status in patients with breast cancer using multidetector computed tomography(MDCT)-based handcrafted and deep radiomics features.Methods:This retrospective study enrolled 339 female patients(primary cohort,n=177;validation cohort,n=162)with pathologically confirmed invasive breast cancer.Handcrafted and deep radiomics features were extracted from the MDCT images during the arterial phase.After the feature selection procedures,handcrafted and deep radiomics signatures and the combined model were built using multivariate logistic regression analysis.Performance was assessed by measures of discrimination,calibration,and clinical usefulness in the primary cohort and validated in the validation cohort.Results:The handcrafted radiomics signature had a discriminative ability with a C-index of 0.739[95%confidence interval(95%CI):0.661-0.818]in the primary cohort and 0.695(95%CI:0.609-0.781)in the validation cohort.The deep radiomics signature also had a discriminative ability with a C-index of 0.760(95%CI:0.690-0.831)in the primary cohort and 0.777(95%CI:0.696-0.857)in the validation cohort.The combined model,which incorporated both the handcrafted and deep radiomics signatures,showed good discriminative ability with a C-index of 0.829(95%CI:0.767-0.890)in the primary cohort and 0.809(95%CI:0.740-0.879)in the validation cohort.Conclusions:Handcrafted and deep radiomics features from MDCT images were associated with HER2 status in patients with breast cancer.Thus,these features could provide complementary aid for the radiological evaluation of HER2 status in breast cancer. | Xiaojun Yang Lei Wu Ke Zhao Weitao Ye Weixiao Liu Yingyi Wang Jiao Li Hanxiao Li Xiaomei Huang Wen Zhang Yanqi Huang Xin Chen Su Yao Zaiyi Liu Changhong Liang | 2020 | Chinese Journal of Cancer Research2020，32，2： | 4 |
| 7 | AI-Enhanced Constellation Design for NOMA System: A Model Driven Method显示文摘Grant-free Non-orthogonal Multiple Access(GF-NOMA)is a promising technology for massive access users and sporadic small-packet transmission for Beyond the 5th Generation mobile communication system(B5G)/the 6th Generation mobile communication system(6G).One of the key aspects in GF-NOMA system is the signature/constellation design.However,due to the channel variation and random activation of users,conventional optimization approaches seem unsuitable for such complex models.In this paper,as an initial attempt,we propose a human intelligence(HI)-guided artificial intelligence(AI)-enhanced signature/constellation design method.By separate design of modulation and power allocation inspired by prior knowledge,the proposed deep neuron network(DNN)for NOMA signature/constellation design not only has smaller size of DNN and less training data,but also has stronger interpretability.In the last section,via simulations we demonstrate that in terms of bit error rate,the proposed scheme can achieve significant performance gain over the conventional NOMA schemes. | Sen Wang Hanxiao Yu Yifei Yuan Guangyi Liu Zesong Fei | 2020 | China Communications2020，17，11： | 3 |
| 8 | Mixture Toxicities of Three Pesticides Having Different Time-Toxicity Profiles显示文摘In the environment,chemical pollutants always exist as mixtures.To evaluate mixture toxicity,we should ex-amine the concentration ratios and the concentration levels of mixture components as well as the interactive time between the components and testing organism.Selecting three pesticides,metribuzin(MET),dodine(DOD)and ri-domil(RID),as mixture components,Vibrio qinghaiensis sp.-Q67 as testing organism,and 96-well microplate as exposure experiment carrier,the luminescence inhibition toxicities of the pesticides and their binary mixtures at six exposure time points(0.25,2,4,8,12,and 16 h)were determined.The results showed that the three pesticides have different time-toxicity profiles.The toxicity of MET increases over time,and those of DOD and RID show a slight decrease or increase in the first 4 h,respectively,and then remain unchanged to 16 h.The toxicities of the binary mixtures consisting of the three pesticides depend on not only the mixture composition but also the exposure time.The time-toxicity profiles of all rays in MET-DOD mixture system are U-shaped curves,those in MET-RID system are basically monotonically increased and those in DOD-RID system are basically monotonically decreased.How-ever,our findings indicate that for the test substances,mixture toxicity can be predicted by the extended concentra-tion addition model. | Mo Yu Shushen Liu Mengchao Wang Fu Chen Hanxiao Tang | 2014 | Chinese Journal of Chemistry2014，32，6： | 2 |
| 9 | Heteroatoms-doped carbon nanocages with enhanced dipolar and defective polarization toward light-weight microwave absorbers显示文摘Light-weight and exceptional microwave absorption are two vital characteristics for microwave absorbers in practical applications,but still face challenges.Herein,we employ a sacrificial template strategy to fabricate heteroatoms-doped carbon nanocages(CNs)via chemical vapor deposition,in which heteroatoms are simultaneously doped into the carbon frameworks by bubbling flowing source liquid.Compared with CNs,doped heteroatoms,accompanied with the inevitably defective arrangements in the lattice,not only decrease the electrical conductivity and balance the impedance characteristics,but also introduce structuralchemical defects and trigger dominant dipolar/defect polarization.As a result,both the minimum reflection loss(R_(L,min))and effective absorption bandwidth(EAB)greatly increase at an ultralow filler loading of 5 wt.%owing to internal hollow void and high specific surface area.The R_(L,min) values reach−53.6,−43.2,and−50.1 dB for N-CNs,S-CNs,and N,S-CNs with the corresponding EAB of 4.9,2.5,and 3.1 GHz,respectively.Furthermore,this work provides an effective strategy for the construction of heteroatoms-doped hollow carbon frameworks in large-scale production and the obtained doped carbon nanocages can be used as light-weight and high-performance microwave absorbers. | Hanxiao Xu Guozheng Zhang Yi Wang Yiruo Wang Huanlei Wang Ying Huang Panbo Liu | 2022 | Nano Research2022，15，10： | 2 |
| 10 | Comparative population genomics dissects the genetic basis of seven domestication traits in jujube显示文摘Jujube(Ziziphus jujuba Mill.)is an important perennial fruit tree with a range of interesting horticultural traits.It was domesticated from wild jujube(Ziziphus acidojujuba),but the genomic variation dynamics and genetic changes underlying its horticultural traits during domestication are poorly understood.Here,we report a comprehensive genome variation map based on the resequencing of 350 accessions,including wild,semi-wild and cultivated jujube plants,at a>15×depth.Using the combination of a genome-wide association study(GWAS)and selective sweep analysis,we identified several candidate genes potentially involved in regulating seven domestication traits in jujube.For fruit shape and kernel shape,we integrated the GWAS approach with transcriptome profiling data,expression analysis and the transgenic validation of a candidate gene to identify a causal gene,ZjFS3,which encodes an ethyleneresponsive transcription factor.Similarly,we identified a candidate gene for bearing-shoot length and the number of leaves per bearing shoot and two candidate genes for the seed-setting rate using GWAS.In the selective sweep analysis,we also discovered several putative genes for the presence of prickles on bearing shoots and the postharvest shelf life of fleshy fruits.This study outlines the genetic basis of jujube domestication and evolution and provides a rich genomic resource for mining other horticulturally important genes in jujube. | Mingxin Guo Zhongren Zhang Yanwei Cheng Sunan Li Peiyin Shao Qiang Yu Junjie Wang Gan Xu Xiaotian Zhang Jiajia Liu Linlin Hou Hanxiao Liu Xusheng Zhao | 2020 | Horticulture Research2020，7，1： | 2 |
| 11 | Wave‑Shaped Piezoelectric Nanofber Membrane Nanogenerator for Acoustic Detection and Recognition显示文摘With the rapid development of internet of things and wearable electronics,how to conveniently power uncountable sensors remains a huge challenge.Energy harvesting strategy is suggested to collect and convert environmental energies into electrical energy.Thereinto,piezoelectric polymers are utilized as fexible harvesters to convert mechanical energy.The latter widely distributes in both our daily life and industrial environment.Intrinsic piezoelectric property further drives piezoelectric polymers to construct fexible self-powered strain sensors.However,relatively low piezoelectric performance restricts their application in detection and conversion of weak mechanical excitations.Herein,wave-shaped 3D piezoelectric device was fabricated by embossing electrospun polyvinylidene fuoride nanofbers.This 3D structured device presents better longitudinal and transverse piezoelectric performance than usual fat-type one.This wave-shaped piezoelectric device was developed for acoustic detection and recognition with a frequency resolution better than 0.1 Hz.This wave-shaped device was capable of frequency spectrum analyses of various sound sources from human and animals and well presents its potential for future wearable acoustic sensors and transducers. | Fan Xu Jiang Yang Ruizhi Dong Hanxiao Jiang Conghuan Wang Weilin Liu Zaixiu Jiang Xiaoqing Zhang Guodong Zhu | 2021 | Advanced Fiber Materials2021，3，6： | 2 |
| 12 | MAT1 correlates with molecular subtypes and predicts poor survival in breast cancer显示文摘Objective:Menage a trois 1(MAT1)is a targeting subunit of cyclin-dependent kinase-activating kinase and general transcription factor IIH kinase,which modulates cell cycle,transcription and DNA repair.Its dysregulation is responsible for diseases including cancers.To further explore the role of MAT1 in breast cancer,we investigated the pathways in which MAT1 might be involved,the association between MAT1 and molecular subtypes,and the role of MAT1 in clinical outcomes of breast cancer patients.Methods:We conducted immunohistochemistry staining on tissue microarray and immunofluorescence staining on sections of MAT1 stable breast cancer cells.Also,we performed Kyoto Encyclopedia of Genes and Genomes pathway analysis,correlation analysis and prognosis analysis on public databases.Results:MAT1 was involved in multiple pathways including normal physiology signaling and disease-related signaling.Furthermore,MAT1 positively correlated with the protein status of estrogen receptor and progesterone receptor,and was enriched in luminal-type and human epidermal growth factor receptor 2-enriched breast cancer in comparison with basal-like subtype at both m RNA and protein levels.Correlation analysis revealed significant association between MAT1 m RNA amount and epithelial markers,mesenchymal markers,cancer stem cell markers,apoptosis markers,transcription markers and oncogenes.Consistently,the results of immunofluorescence stain indicated that MAT1 overexpression enhanced the protein abundance of epidermal growth factor receptor,vimentin,sex determining region Y-box 2 and sine oculis homeobox homolog 1.Importantly,Kaplan-Meier Plotter analysis reflected that MAT1 could serve as a prognostic biomarker predicting worse relapse-free survival and metastasis-free survival.Conclusions:MAT1 is correlated with molecular subtypes and is associated with unfavorable prognosis for breast cancer patients. | Hanxiao Xu Xianguang Bai Shengnan Yu Qian Liu Richard G Pestell Kongming Wu | 2018 | Chinese Journal of Cancer Research2018，30，3： | 2 |
| 13 | The radial organization of neuronal primary cilia is acutely disrupted by seizure and ischemic brain injury显示文摘Neuronal 主要的睫是极其涉及中央神经系统(CNS ) 的合适的生长,发展,和功能的感觉细胞器。最近的工作也建议他们在 CNS 的上下文发信号损害,和那反常睫的发信号可以在神经病学的疾病被含有。我们确定了的方法 neuronal 的分发在整个由为主要的睫标记 adenylyl cyclase III (ACIII ) 染色并且关于全球、本地的并列飞机测量主要的睫的角度的 immunohistochemical 的正常成年老鼠大脑的主要的睫排列。我们然后介绍了尖锐大脑 insulttemporal 的二个不同模型脑叶抓住和服的局部缺血,和 re-examined neuronal 主要的睫分发,以及睫的长度和神经原怀有的比例睫。在基础条件下面的结果,外皮的睫关于外皮的表面放射状地排列自己,当时在有牙齿的回转的睫关于小粒房间层放射状地排列自己。在 striatum 和丘脑的神经原的睫由对比,展出睫的安排的宽分布。在尖锐大脑侮辱的两个盒子中,主要的睫排列显著地以一种区域特定的方式被破坏,与优先地破坏的侮辱影响的区域。进一步,二个模型在睫的长度上支持了微分效果,当仅仅局部缺血模型减少了时 ciliated 房间的比例。结论这些调查结果为 neuronal 的地区性的解剖组织提供证据在成年大脑的主要的睫并且建议各种各样的大脑侮辱可以破坏这个组织。 | Gregory W. Kirschen Hanxiao Liu Tracy Lang Xuelin Liang Shaoyu Ge Qiaojie Xiong | 2017 | Frontiers in Biology2017，12，2： | 1 |
| 14 | Hydrothermal Zircon Geochronology in the Shangxu Gold Deposit and its Implication for the Early Cretaceous Orogenic Gold Mineralization in the Middle Bangonghu–Nujiang Suture Zone显示文摘As a typical orogenic gold deposit in Tibet,Shangxu gold deposit is located at the Bangong Lake–Nujiang River Metallogenic Belt in the south of Qinghai–Tibet Plateau.In this paper,zircon U-Pb dating,trace elements and Hf isotopic analysis were performed on Au-bearing quartz veins in the Shangxu gold deposit.Zircons from Au-bearing quartz veins can be divided into three types:detrital,magmatic,and hydrothermal zircons.There are two age peaks in detrital zircons:ca.1700 Ma and ca.2400 Ma.There are two groups of concordant ages including 157±4 Ma(MSWD=0.69)and 120±1 Ma(MSWD=0.19)in magmatic zircons,in whichεH f(t)value of ca.120 Ma from the magmatic zircons range from+8.24 to+12.9.An age of 119±2 Ma(MSWD=0.42)was yielded from hydrothermal zircons,and theirεH f(t)values vary between+15.7 and+16.4.According to sericite Ar-Ar age,this paper suggests that an age of 119±2 Ma from hydrothermal zircons represent the formation age of the Shangxu gold Deposit,and its mineralization should be related to the collision between Lhasa Block and Qiangtang Block.The metallogenic age is basically the same as the diagenetic age of Mugagangri granite,andεH f(t)value of hydrothermal zircon is significantly higher than that of the contemporaneous magmatic zircon,which indicates that there is a genetic relationship between the gold mineralization and the deep crust-mantle magmatism. | HUANG Hanxiao LUOSANG Jiancuo DAI Zuowen LIU Hong FU Jiangang LI Guangming CAO Huawen ZHOU Qing | 2021 | Acta Geologica Sinica(English Edition)2021，95，4： | 1 |
| 15 | et, Multiple Vortex Body Vortex Numerical Simulation显示文摘 | Hanxiao LIU Zhong LIU | 2011 | Advanced Materials Research2011，32，14： | 1 |
| 16 | Multiple vortex body vortex numerical simulation显示文摘 | Hanxiao Liu Zhong Liu | 2011 | Advanced Materials Research2011，32，14： | 1 |
| 17 | Nitrogen-Doped TiO_2–C Composite Nanofibers with High-Capacity and Long-Cycle Life as Anode Materials for Sodium-Ion Batteries显示文摘Nitrogen-doped TiO_2–C composite nanofibers(TiO_2/N–C NFs) were manufactured by a convenient and green electrospinning technique in which urea acted as both the nitrogen source and a pore-forming agent. The TiO_2/N–C NFs exhibit a large specific surface area(213.04 m^2 g^(-1)) and a suitable nitrogen content(5.37 wt%). The large specific surface area can increase the contribution of the extrinsic pseudocapacitance, which greatly enhances the rate capability. Further, the diffusion coefficient of sodium ions(DNa_+) could be greatly improved by the incorporation of nitrogen atoms. Thus, the TiO_2/N–C NFs display excellent electrochemical properties in Na-ion batteries. A TiO_2/N–C NF anode delivers a high reversible discharge capacity of 265.8 mAh g^(-1) at 0.05 A g^(-1) and an outstanding long cycling performance even at a high current density(118.1 m Ah g^(-1)) with almost no capacity decay at 5 A g^(-1) over 2000 cycles. Therefore, this work sheds light on the application of TiO_2-based materials in sodium-ion batteries. | Su Nie Li Liu Junfang Liu Jianjun Xie Yue Zhang Jing Xia Hanxiao Yan Yiting Yuan Xianyou Wang | 2018 | Nano-Micro Letters2018，10，4： | 1 |
| 18 | Clinical outcomes of atezolizumab in combination with etoposide/platinum for treatment of extensive-stage small-cell lung cancer:A real-world,multicenter,retrospective,controlled study in China显示文摘Objective:Atezolizumab along with chemotherapy has prolonged the survival of patients with extensive-stage small-cell lung cancer(ES-SCLC)worldwide,although real-world(RW)data are lacking in China.This study was designed to evaluate the efficacy and clinical outcomes of atezolizumab plus etoposide/platinum(EP).Methods:Data obtained in this retrospective study were captured from six oncology units of five medical facilities from January 2019 to April 2022.For first-line treatments,atezolizumab combined with EP vs.EP alone,we primarily evaluated progression-free survival(PFS);other efficacy indicators,including overall survival(OS),objective response rate(ORR),and patterns of SCLC progression and adverse events(AEs)were assessed.Results:The primary analysis included data from 225 patients,of whom 133 received EP along with atezolizumab(atezolizumab group)and 92 received EP alone(EP group).The PFS duration of the atezolizumab group[7.10 months;95%confidence interval(95%CI),6.53-9.00]exceeded that of the EP group(6.50 months;95%CI,4.83-7.53).Overall,the hazard ratio(HR)was 0.69(95%CI,0.49-0.97)(P=0.029);particularly,the HR was 0.54(95%CI,0.36-0.80)among patients undergoing≥4 chemotherapy cycles and 0.33(95%CI,0.20-0.56)among individuals with atezolizumab maintenance.The ORR and disease-control rate(DCR)were similar between the two groups.Because of incomplete OS data,the median OS was not determined for either group.Bone marrow suppression was the most common AE detected(58.6%)in the atezolizumab group.Immune-related AEs occurred in 19 patients in the atezolizumab group(14.3%),with only one case of grade 3 encephalitis.Conclusions:This RW study in China demonstrated improved clinical outcomes of atezolizumab along with EP for ES-SCLC,particularly in the chemosensitive population.These results align with the results of the IMpower133 study,although the impact of this treatment modality on OS warrants additional follow-up studies. | Hanxiao Chen Xiangjuan Ma Jie Liu Yu Yang Yong Fang Liping Wang Jian Fang Jun Zhao Minglei Zhuo | 2022 | Chinese Journal of Cancer Research2022，34，4： | 1 |
| 19 | Multiple Vortex Body Vortex Numerical Simulation显示文摘 | Hanxiao LIU Zhong LIU | | 0，，14： | 1 |
| 20 | Multiple Vortex Body Vortex Numerical Simulation显示文摘 | Hanxiao LIU Zhong LIU | | 0，，14： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员