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| 1 | Progress in electrical energy storage system:A critical review显示文摘Electrical energy storage technologies for stationary applications are reviewed. Particular attention is paid to pumped hydroelectric storage, compressed air energy storage, battery, flow battery, fuel cell, solar fuel, superconducting magnetic energy storage, flywheel, capacitor/supercapacitor, and thermal energy storage. Comparison is made among these technologies in terms of technical characteris- tics, applications and deployment status. | Haisheng Chen Thang Ngoc Cong Wei Yang Chunqing Tan Yongliang Li Yulong Ding | 2009 | Progress in Natural Science:Materials International2009，19，3： | 205 |
| 2 | A journey to understand wheat Fusarium head blight resistance in the Chinese wheat landrace Wangshuibai显示文摘Fusarium head blight(FHB) or scab caused by Fusarium graminearum is a major threat to wheat production in China as well as in the world. To combat this disease, multiple efforts have been carried out internationally. In this article, we review our long-time effort in identifying the resistance genes and dissecting the resistance mechanisms by both forward and reverse genetics approaches in the last two decades. We present recent progress in resistance QTL identification, candidate functional gene discovery, marker-assisted improvement of FHB resistant varieties, and findings in investigating association of signal molecules, such as Ca^(++),SA, JA, and ET, with FHB response, with the assistance from rapidly growing genomics platforms. The information will be helpful for designing novel and efficient approaches to curb FHB. | Haiyan Jia Jiyang Zhou Shulin Xue Guoqiang Li Haisheng Yan Congfu Ran Yiduo Zhang Jinxing Shi Li Jia Xin Wang Jing Luo Zhengqiang Ma | 2018 | The Crop Journal2018，6，1： | 24 |
| 3 | Age-related rhesus macaque models of COVID-19显示文摘Background:Since December 2019,an outbreak of the Corona Virus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus(SARS-CoV-2)in Wuhan,China,has become a public health emergency of international concern.The high fatality of aged cases caused by SARS-CoV-2 was a need to explore the possible age-related phenomena with non-human primate models.Methods:Three 3-5 years old and two 15 years old rhesus macaques were intratracheally infected with SARS-CoV-2,and then analyzed by clinical signs,viral replication,chest X-ray,histopathological changes and immune response.Results:Viral replication of nasopharyngeal swabs,anal swabs and lung in old monkeys was more active than that in young monkeys for 14 days after SARS-CoV-2 challenge.Monkeys developed typical interstitial pneumonia characterized by thickened alveolar septum accompanied with inflammation and edema,notably,old monkeys exhibited diffuse severe interstitial pneumonia.Viral antigens were detected mainly in alveolar epithelial cells and macrophages.Conclusion:SARS-CoV-2 caused more severe interstitial pneumonia in old monkeys than that in young monkeys.Rhesus macaque models infected with SARS-CoV-2 provided insight into the pathogenic mechanism and facilitated the development of vaccines and therapeutics against SARS-CoV-2 infection. | Pin Yu Feifei Qi Yanfeng Xu Fengdi Li Peipei Liu Jiayi Liu Linlin Bao Wei Deng Hong Gao Zhiguang Xiang Chong Xiao Qi Lv Shuran Gong Jiangning Liu Zhiqi Song Yajin Qu Jing Xue Qiang Wei Mingya Liu Guanpeng Wang Shunyi Wang Haisheng Yu Xing Liu Baoying Huang Wenling Wang Li Zhao Huijuan Wang Fei Ye Weimin Zhou Wei Zhen Jun Han Guizhen Wu Qi Jin Jianwei Wang Wenjie Tan Chuan Qin | 2020 | Animal Models and Experimental Medicine2020，3，1： | 22 |
| 4 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 5 | Effects of Shuanghuanglian oral liquids on patients with COVID-19:a randomized,open-label,parallel-controlled,multicenter clinical trial显示文摘We conducted a randomized,open-label,parallel-controlled,multicenter trial on the use of Shuanghuanglian(SHL),a traditional Chinese patent medicine,in treating cases of COVID-19.A total of 176 patients received SHL by three doses(56 in low dose,61 in middle dose,and 59 in high dose)in addition to standard care.The control group was composed of 59 patients who received standard therapy alone.Treatment with SHL was not associated with a difference from standard care in the time to disease recovery.Patients with 14-day SHL treatment had significantly higher rate in negative conversion of SARS-CoV-2 in nucleic acid swab tests than the patients from the control group(93.4%vs.73.9%,P=0.006).Analysis of chest computed tomography images showed that treatment with high-dose SHL significantly promoted absorption of inflammatory focus of pneumonia,which was evaluated by density reduction of inflammatory focus from baseline,at day 7(mean difference(95%CI),−46.39(−86.83 to−5.94)HU;P=0.025)and day 14(mean difference(95%CI),−74.21(−133.35 to−15.08)HU;P=0.014).No serious adverse events occurred in the SHL groups.This study illustrated that SHL in combination with standard care was safe and partially effective for the treatment of COVID-19. | Li Ni Zheng Wen Xiaowen Hu Wei Tang Haisheng Wang Ling Zhou Lujin Wu Hong Wang Chang Xu Xizhen Xu Zhichao Xiao Zongzhe Li Chene Li Yujian Liu Jialin Duan Chen Chen Dan Li Runhua Zhang Jinliang Li Yongxiang Yi Wei Huang Yanyan Chen Jianping Zhao Jianping Zuo Jianping Weng Hualiang Jiang Dao Wen Wang | 2021 | Frontiers of Medicine2021，15，5： | 7 |
| 6 | Concept of the solar ring mission:An overview显示文摘The concept of the Solar Ring mission was gradually formed from L5/L4 mission concept, and the proposal of its pre-phase study was funded by the National Natural Science Foundation of China in November 2018 and then by the Strategic Priority Program of Chinese Academy of Sciences in space sciences in May 2019. Solar Ring mission will be the first attempt to routinely monitor and study the Sun and inner heliosphere from a full 360-degree perspective in the ecliptic plane. The current preliminary design of the Solar Ring mission is to deploy six spacecraft, grouped in three pairs, on a sub-AU orbit around the Sun. The two spacecraft in each group are separated by about 30?and every two groups by about 120?. This configuration with necessary science payloads will allow us to establish three unprecedented capabilities:(1) determine the photospheric vector magnetic field with unambiguity,(2) provide 360-degree maps of the Sun and the inner heliosphere routinely, and(3) resolve the solar wind structures at multiple scales and multiple longitudes. With these capabilities, the Solar Ring mission aims to address the origin of solar cycle, the origin of solar eruptions, the origin of solar wind structures and the origin of severe space weather events. The successful accomplishment of the mission will advance our understanding of the star and the space environment that hold our life and enhance our capability of expanding the next new territory of human. | WANG YuMing JI HaiSheng WANG YaMin XIA LiDong SHEN ChengLong GUO JingNan ZHANG QuanHao HUANG ZhengHua LIU Kai LI XiaoLei LIU Rui WANG JingXiu WANG Shui | 2020 | Science China(Technological Sciences)2020，63，9： | 4 |
| 7 | Controlled fabrication and electrical-magnetic properties of Poly(OT-co-AN)/Ba_(0.8)La_(0.2)Al_2Fe_(10)O_(19) composites显示文摘Poly(OT-co-AN)/Ba0.8La0.2Al2Fe10O19(Poly(OT-co-AN)/BLAF) composites were fabricated by in situ polymerization method.It was investigated that of mass rate of momomer(mOT/mAN),polymeration temperature and time,and feeding ratio of BLAF effect on the structures,morphology,conductivity,magnetic property of composites by the orthogonal optimum design.The results indicated that poly(OT-co-AN) copolymer had a better coating on BLAF particles,and there were some interactions between components in the composites.The magnetic properties of the composites were related to content of the magnetic BLAF particles in it.The feeding ratio of BLAF had a significant influence on constitute and conductivity of the composites,followed by the temperature.The reflection loss and the effective bandwidth of composites for electromagnetic wave were at-tributed to the synergistic effect between poly(OT-co-AN) and BLAF.The poly(OT-co-AN)/BLAF composites with mass ratio of BLAF to mix monomer(mOT/mAN =1:1) equal to 5/1 at 10 h in 25°C had a maximum synergistic effect between its compo-nents,showed a maximum reflection loss of ?26.94 dB at 14.10 GHz and an available bandwidth of 8.54 GHz.It was sug-gested that the composites can be used as a advancing absorption and shielding materials for electromagnetic wave due to their favorable microwave absorption properties. | CHEN KeYu XU QingQing LI LiangChao TONG GuoXiu QIAN HaiSheng XIAO QiuShi XU Feng | 2012 | Science China(Technological Sciences)2012，55，1： | 4 |
| 8 | Purification of starch and phosphorus wastewater using core-shell magnetic seeds prepared by sulfated roasting显示文摘Core-shell magnetic seeds with certain adsorption capacity that were prepared by sulfated roasting, served as the core of a magnetic separation technology for purification of starch wastewater. XRD and SEM results indicate that magnetite's surface transformed to be porous α-Fe_2O_3 structure. Compared with magnetite particles, the specific surface area was significantly improved to be 8.361 from 2.591 m^2/g, with little decrease in specific susceptibility. Zeta potential, FT-IR and XPS experiments indicate that both phosphate and starch adsorbed on the surface of the core-shell magnetic seeds by chemical adsorption, which fits well with the Langmuir adsorption model. The porous surface structure of magnetic seeds significantly contributes to the adsorption of phosphate and starch species, which can be efficiently removed to be 1.51 mg/L(phosphate) and 9.51 mg/L(starch) using magnetic separation. | Chunjie Du Jinsheng Yu Wei Sun Haisheng Han Yuehua Hu Pan Chen Panpan Hou Runqing Liu Li Wang Yue Yang Ruohua Liu Lei Sun | 2019 | Journal of Environmental Sciences2019，31，7： | 4 |
| 9 | High Energy X-ray Telescope Data Analysis Method显示文摘The science analysis of the data from the High Energy X-ray Telescope(HE) on the Hard X-ray Modulation Telescope(HXMT) satellite is organized in three stages:calibration,screening and extraction of high-level scientific products.At the first stage,the raw PHA value of each event is converted to PI value accounting for temporal changes in gain and energy offset.At the second stage,the calibrated events are screened by applying cleaning criteria.At the third stage,scientific products,i.e.spectra,light curves and redistribution matrix files,are extracted.This work will introduce the three stages as well as the screening criteria and the data combining method. | ZHAO Haisheng LI Chengkui LI Xiaobo NIE Jianyin GE Mingyu PAN Yuanyue SONG Liming | 2016 | 空间科学学报2016，36，6： | 3 |
| 10 | Large piezoelectric response in a family of metal-free perovskite ferroelectric compounds from first-principles calculations显示文摘Metal-free organic perovskite ferroelectric materials have been shown recently to have a number of attractive properties,including high spontaneous polarization and piezoelectric coefficients.In particular,slow evaporation of solutions containing organic amines,inorganic ammoniums,and dilute hydrohalogen acid has been shown to produce several attractive materials in the MDABCO-NH_(4)-I_(3) family(MDABCO is N-methyl-N’-diazabicyclo[2,2,2]octonium).In the present work,we study by first-principles calculations the origin of polarizaiton,electronic density of state,piezoelectric response,and elastic properties of MDABCO-NH_(4)-X_(3)(X=Cl,Br,I).We find that the dipole moments of the MDABCO and NH_(4) groups are negligible,and the large spontaneous polarization of MDABCONH_(4)-I_(3) mainly results from MDABCO and NH_(4) being off-center relative to I ions.Although the piezoelectric response of organic materials is usually very weak,we observe large piezoelectric strain components,d_(x4) and d_(x5);the calculated d_(x5) is 119 pC/N for MDABCO-NH_(4)-Cl_(3),248 pC/N for MDABCO-NH_(4)-Br_(3) and 178 pC/N for MDABCO-NH_(4)-I_(3).The large value of dx5 is found to be closely related with the large value of elastic compliance tensor,s44.These results show that MDABCO-NH_(4)-X_(3) metal-free organic perovskites have large piezoelectric response with soft elastic properties. | Hui Wang Huihui Liu Zeyu Zhang Zihan Liu Zhenlong Lv Tongwei Li Weiwei Ju Haisheng Li Xiaowu Cai Han Han | 2019 | npj Computational Materials2019，，1： | 3 |
| 11 | Effect of amino acid mutation at position 127 in 3A of a rabbitattenuated foot-and-mouth disease virus serotype Asia1 on viral replication and infection显示文摘An amino acid mutation(R127→I) in the 3A non-structural protein of an FMDV serotype Asia1 rabbit-attenuated ZB strain was previously found after attenuation of the virus. To explore the effects of this mutation on viral replication and infection, the amino acid residue isoleucine(I) was changed to arginine(R) in the infectious cDNA clone of the rabbit-attenuated ZB strain by sitedirected mutagenesis, and the R127-mutated virus was rescued. BHK monolayer cells and suckling mice were inoculated with the R127-mutated virus to test its growth property and pathogenicity, respectively. The effects of the R127 mutation on viral replication and virulence were analyzed. The data showed that there was a slight difference in plaque morphology between the R127-mutated and wild-type viruses. The growth rate of the mutated virus was lower in BHK-21 cells and its virulence in suckling mice was also attenuated. This study indicates that the R127 mutation in 3A may play an important role in FMDV replication in vitro and in pathogenicity in suckling mice. | Aiguo Xin Mingwang Zhu Qi Hu Haisheng Miao Zhenqi Peng Yuwen He Lin Gao Huachun Li | 2014 | Virologica Sinica2014，29，5： | 2 |
| 12 | An Area Weighted Surface Sampling Method for 3D Model Retrieval显示文摘3D model feature extraction is a key step for geometric content based 3D model retrieval. A 3D model is usually expressed by patches and it has large amount of data. Pseudo-random sequential Monte Carlo surface sampling method is used to sample 3D model data. It has strong randomness. The sampling results are not uniform, which worsen the efficiency and precision of feature extraction. An area weighted surface sampling method for 3D Models is proposed. The larger area patches get the higher probability of sampling. The sampling points are evenly distributed in sampling space, which represent more accurate 3D model features. Experiments show that the proposed method needs less computing resources. Even when there are less sampling points, it can still keep high calculation accuracy and stability. | LI Haisheng LIU Xuan LAI Long CAI Qiang DU Junping | 2014 | Chinese Journal of Electronics2014，23，3： | 2 |
| 13 | Overview to the Hard X-ray Modulation Telescope (Insight-HXMT) Satellite显示文摘As China’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band(1-250 ke V) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 Me V. It was designed to perform pointing, scanning and gamma-ray burst(GRB)observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be reconstructed.Here we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results. | Shuang-Nan Zhang TiPei Li FangJun Lu LiMing Song YuPeng X u CongZhan Liu Yong Chen XueLei Cao QingCui Bu Zhi Chang Gang Chen Li Chen TianXiang Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong Yuan Yuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan Can Gungor ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge Ou JinLu Qu Na Sai RenCheng Shang GuoHong Shen Liang Sun Ying Tan Lian Tao YouLi Tuo Chen Wang ChunQin Wang GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BaiYang Wu BoBing Wu Mei Wu GuangCheng Xiao ShaoLin Xiong LinLi Yan JiaWei Yang Sheng Yang YanJi Yang QiBin Yi Bin Yuan AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang ShenYi Zhangs Shu Zhang Tong Zhang WanChang Zhang Wei Zhang WenZhao Zhang Yi Zhang YiFei Zhang YongJie Zhang Yue Zhang Zhao Zhang Zhi Zhang ZiLiang Zhang HaiSheng Zhao XiaoFan Zhao ShiJie Zheng JianFeng Zhou YuXuan Zhu Yue Zhu RenLin Zhuang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 2 |
| 14 | The calibration and initial results of the HeI D3 line flash spectrum obtained during the 2008 total solar eclipse显示文摘The flash spectra in the HeI D3 line were obtained during the 2008 total solar eclipse. This paper describes the instrument and the calibration of the obtained flash spectrum, and presents our initial results. The average integrated intensity is Eave = 8.13×1013 erg·cm-1· s-1·ster-1 at h = 1100 km, which confirms that the HeI D3 emission is negatively correlated with the solar activity. The surface brightness reaches a maximum of F ave = 8.25×105 erg·cm-2·s-1·ster-1 at about h ≈ (1290 ± 75) km and then decreases exponentially with height when h >1800 km with an exponential index β = 1.63×10-8 cm-1. | LI Hui JI HaiSheng NI HouKun ZHANG HaiYing ZHANG YaNan LIU HongRui DENG YuanYong WANG DongGuang DU QiuSheng ZHOU TuanHui LI JingWei SHEN JinHua | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，11： | 2 |
| 15 | Chemo-and Biostratigraphy of the Jurassic Oil Shales from the Qiangtang Basin,Northern Tibet,China:A Case Study of the Toarcian Oceanic Anoxic Event显示文摘The marine oil shales of the Qiangtang Basin, northern Tibet, exposed in the Biluo Co, Tuonamu, Shenglihe and Changsheshan areas are believed to be important petroleum source rocks. This work comprehensively analyzed the carbon isotopes, trace elements, and calcareous nannofosills, ammonites and bivalves of the Biluo Co section in the Qiangtang Basin. The organic carbon isotopes show a positive excursion close to 2.17‰(relative to PDB), which, albeit significantly smaller, may also be associated with other Early Toarcian Oceanic Anoxic Events(T-OAE) in the European epicontinental seas and the Tethyan continental margins. Coinciding with the Early Toarcian transgression, the oxygen deficiency in bottom water had led to dysoxic-anoxic conditions and deposition of black shales lacking benthic fauna. Under such condition, the redox-sensitive trace metals such as Mo, V, Ni, Cr, and U were enriched, in conjunction with high planktonic productivity of Watznaueriaceae calcareous nannofossils. Comparison of the results with the records of chemo-and biostratigraphy, as well as the palaeogeography during the Early Jurassic suggests that the anoxia linked to the Early Toarcian oceanic anoxic event was mainly caused by the high surface water temperature, sea-level rise and an increase of surface water productivity. | CHEN Lan XU Guiwen DA Xuejuan YI Haisheng ZHU Zhangxiong HUANG Zhaohui LI Xiaogang | 2017 | Acta Geologica Sinica(English Edition)2017，91，2： | 2 |
| 16 | Protective effect of Tongdu Tiaoshen acupuncture combined with Xiaoxuming decoction(小续命汤)on dopaminergic neurons in Parkinson’s disease model显示文摘OBJECTIVE:To explore the possible mechanism of Tongdu Tiaoshen acupuncture combined with Xiaoxuming decoction(小续命汤,XXMD)in the treatment of Parkinson’s disease(PD).METHODS:C57BL/6 mice were randomly divided into eight groups(n=12),including blank group,model group,medication group,acupuncture group,high-dose XXMD group(XXMD-H),low-dose XXMD group(XXMD-L),acupuncture combined with high-dose XXMD group(A+H),and acupuncture combined with low-dose XXMD group(A+L).After treatment for 6 weeks,dopamine(DA)neurons and the pathological changes of tyrosine hydroxylase(TH)positive cells were observed.The enzyme-linked immunosorbent assay(ELISA)was used to measure the content of DA and the level of interleukin-1β(IL-1β),interleukin-6(IL-6),interleukin-10(IL-10)and tumor necrosis factor alpha(TNF-α).The m RNA level of PINK1 and Parkin and the protein expression of Nix,PINK1 and Parkin in the substantia nigra were also detected.RESULTS:Combination treatment effectively ameliorated the symptoms of PD.Compared with model group,combined treatment significantly up-regulated the protein expression of Nix,Parkin and PINK1 and the m RNA levels of PINK1 and Parkin in the substantia nigra(P<0.0001,P<0.001,P<0.01 or P<0.05).Furthermore,the levels of pro-inflammation cytokines were obviously decreased after combination therapy,while IL-10 content was increased remarkably(P<0.01).CONCLUSION:Compared with each treatment alone,combination therapy improved the pathological damage of DA neurons of PD mice more effectively.The possible mechanism may be attributed to the up-regulated level of mitochondrial autophagy and improved mitochondrial function.These results provide fresh insight into the mechanism of co-treatment with Tongdu Tiaoshen acupuncture and XXMD for PD. | WU Haiyang WANG Ying HAN Wei LI Huihui JI Haisheng LIU Xiuxiu | 2023 | Journal of Traditional Chinese Medicine2023，43，3： | 2 |
| 17 | Effect of sodium ions on propylene epoxidation catalyzed by titanium silicalite显示文摘 | Li Gang Wang Xiangsheng Yan Haisheng | 2001 | Applied Catalysis A: General2001，218，12： | 1 |
| 18 | Epoxidation of propylene using supported titanium silicalite catalysts显示文摘 | Li Gang Wang Xiangsheng Yan Haisheng | 2002 | Applied Catalysis A: General2002，236，： | 1 |
| 19 | Discriminating against injectable fat emulsions with similar formulation based on water quenching fluorescent probe显示文摘The discrimination against nutritional fat emulsion injections was considered by imaging tools,which aims to elucidate the in vivo behaviors of nanoemulsions.In this study,20%nutritional fat emulsion injections were selected from different company including original and generic products.Meanwhile,a water quenching fluorescent probe(P2)was used to label them by an incubation method.The fluorescent intensity analysis of blood-borne fluorescence reveals rapid clearance of nanoemulsion in all groups,which shows'L'-type blood kinetic profiles.However,these kinetic parameters do not have significant difference.Following intravenous administration,the nanoemulsions in all groups concomitantly accumulated in organs of reticulo-endothelial system(RES),such as liver and spleen,and were cleared from body circulation mostly after 12 h.AUC(0-t)of organs from different groups showed dissimilar results in some organs.These intuitional results are of significance in understa nding the in vivo behaviors of nanoemulsions,which can provide a new way to discriminate against nutritional fat emulsions. | Jinlong Yang Zirong Dong Wenjuan Liu Haisheng He Wufa Fan Yi Lu Wei Wu Li Gan Jianping Qi | 2020 | Chinese Chemical Letters2020，31，3： | 1 |
| 20 | Progress on the table grape breeding in foreign during the past 20 years显示文摘 | FAN Xiucai ZHANG Ying JIANG Jianfu SUN Haisheng LI Min LIU Chonghuai | 2011 | Sino-Overseas Grapevine&Wine2011，，2： | 1 |
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