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| 1 | High-precision relocation of the aftershock sequence of the January 8,2022,M_(S)6.9 Menyuan earthquake显示文摘The 2022 Menyuan M_(S)6.9 earthquake,which occurred on January 8,is the most destructive earthquake to occur near the Lenglongling(LLL)fault since the 2016 Menyuan M_(S)6.4 earthquake.We relocated the mainshock and aftershocks with phase arrival time observations for three days after the mainshock from the Qinghai Seismic Network using the double-difference method.The total length and width of the aftershock sequence are approximately 32 km and 5 km,respectively,and the aftershocks are mainly concentrated at a depth of 7-12 km.The relocated sequence can be divided into 18 km west and 13 km east segments with a boundary approximately 5 km east of the mainshock,where aftershocks are sparse.The east and west fault structures revealed by aftershock locations differ significantly.The west fault strikes EW and inclines to the south at a 71°-90°angle,whereas the east fault strikes 133°and has a smaller dip angle.Elastic strain accumulates at conjunctions of faults with different slip rates where it is prone to large earthquakes.Based on surface traces of faults,the distribution of relocated earthquake sequence and surface ruptures,the mainshock was determined to have occurred at the conjunction of the Tuolaishan(TLS)fault and LLL fault,and the west and east segments of the aftershock sequence were on the TLS fault and LLL fault,respectively.Aftershocks migrate in the early and late stages of the earthquake sequence.In the first 1.5 h after the mainshock,aftershocks expand westward from the mainshock.In the late stage,seismicity on the northeast side of the east fault is higher than that in other regions.The migration rate of the west segment of the aftershock sequence is approximately 4.5 km/decade and the afterslip may exist in the source region. | Liping Fan Boren Li Shirong Liao Ce Jiang Lihua Fang | 2022 | Earthquake Science2022，35，2： | 14 |
| 2 | Watering techniques and zero-valent iron biochar pH effects on As and Cd concentrations in rice rhizosphere soils,tissues and yield显示文摘Zero-valent iron amended biochar(ZVIB)has been proposed as a promising material in immobilizing heavy metals in paddy fields.In this study,the impacts of p H of ZVIB(p H 6.3 and p H 9.7)and watering management techniques(watering amount in the order of CON(control,5/72)>3/72>1-3/72>3/100>1/72,with 5/72,for example,representing irrigation given to 5 cm above soil surface in 72 hr regular interval)on As and Cd bioavailability for rice and its grain yield(Yield BR)were investigated in a pot experiment.Brown rice As(As BR)content was irrelative to the watering treatments,while significantly decreased(>50%)with the addition of both ZVIB materials.The diminutions of brown rice Cd(Cd BR)content as well as the Yield BR were highly dependent on both the soil amendment materials’p H and watering amount.Among all the watering treatments,3/72 treatment(15%less irrigation water than the CON)with ZVIB 6.3 amendment was the optimum fit for simultaneous reduction of As BR(50%)and Cd BR contents(19%)as well as for significant increment(12%)of the Yield BR.Although high pH(9.7)ZVIB application could also efficiently decrease As and Cd contents in brown rice,it might risk grain yield lost if appropriate(e.g.3/72 in our study)watering management technique was not chosen.Therefore,ZVIB would be an environmentally friendly option as an amendment material with proper selection of watering management technique to utilize As and Cd co-contaminated arable soils safely for paddy cultivation. | Md Shafiqul Islam Yali Chen Liping Weng Jie Ma Zulqarnain Haider Khan Zhongbin Liao Abdoul Salam Issiaka Abdoul Magid Yongtao Li | 2021 | Journal of Environmental Sciences2021，33，2： | 9 |
| 3 | Endovascular therapy for Acute ischemic Stroke Trial (EAST): study protocol for a prospective, multicentre control trial in China显示文摘Background and purpose:5 recent trials have shown the benefit of endovascular treatment for acute ischaemic stroke(AIS)due to large vessel occlusion of the anterior circulation.This study aims to evaluate the safety and efficacy of Solitaire thrombectomy in patients with moderate-to-severe stroke in the Chinese population,which has a high prevalence of intracranial atherosclerosis.Methods and analysis:This multicentre prospective control study will involve 17 stroke centres in China,and plans to recruit 150 patients in the intervention group,and 150 patients in the medical group,in which patients meet enrolment criteria but refuse intervention.Patients with AIS due to large vessel occlusion indicated for treatment with Solitaire stent retriever within 12 hours of symptom onset,and who meet the inclusion and exclusion criteria,will be enrolled in this study.The primary efficacy endpoint is functional independence as defined by a modified Rankin Scale(mRS)score≤2 at 90 days or by functional improvement as defined by mRS,using shift analysis.The procedural efficacy endpoint is arterial recanalisation of the occluded target vessel measured by a modified Thrombolysis in Cerebral Infarction(mTICI)score equal or superior to 2b right following the use of the study device.The primary safety endpoint is symptomatic intracranial haemorrhage(sICH)within 24±3 hours postprocedure.Ethics and dissemination:The protocol was approved by the Ethics Committee at the coordinating centre and by the local Institutional Review Board of each participating centre.Trial registration number:NCT02350283. | Zhongrong Miao Xiaochuan Huo Feng Gao Xiaoling Liao Chunjuan Wang Ya Peng Yibin Cao Shengli Chen Meng Zhang Changchun Jiang Xiaoxiang Peng Cunfeng Song Liping Wei Qiyi Zhu Zaiyu Guo Li Liu Hang Lin Hua Yang Wei Wu Hui Liang Anding Xu Kangning Chen Xingquan Zhao Yuesong Pan Hao Li Liping Liu Yilong Wang Yongjun Wang EAST investigators | 2016 | Stroke & Vascular Neurology2016，1，2： | 8 |
| 4 | Surface plasmons interference nanogratings:wafer-scale laser direct structuring in seconds显示文摘It is always a great challenge to bridge the nano-and macro-worlds in nanoscience,for instance,manufacturing uniform nanogratings on a whole wafer in seconds instead of hours even days.Here,we demonstrate a single-step while extremely high-throughput femtosecond laser scanning technique to obtain wafer-scale,highly regular nanogratings on semiconductor-on-metal thin films.Our technique takes advantage of long-range surface plasmons-laser interference,which is regulated by a self-initiated seed.By controlling the scanning speed,two types of nanogratings are readily manufactured,which are produced by either oxidation or ablation.We achieve a record manufacturing speed(>1 cm^(2)s^(-1)),with tunable periodicity of∧<1μm.The fractional variation of their periodicity is evaluated to be as low as△∧/∧≈0.5%.Furthermore,by utilizing the semiconductor-on-metal film-endowed interference effects,an extremely high energy efficiency is achieved via suppressing light reflection during femtosecond laser nano-processing.As the fabricated nanogratings exhibit multi-functionality,we exemplify their practical applications in highly sensitive refractive index sensing,vivid structural colors,and durable superhydrophilicity. | liao Geng Wei Yan Liping Shi Min Qiu | 2022 | Light(Science & Applications)2022，11，7： | 8 |
| 5 | In situ generated thrombin in the protein corona of zeolites: Relevance of the functional proteins to its biological impact显示文摘到 nanomaterial 表面的血浆蛋白质的吸附在他们的简历功能上有大影响。然而,有在在蛋白质日冕和材料的生物身份的功能的蛋白质之间的关系的有限理解。这里,我们证明在里面 situ 在 Ca 沸石表面的蛋白质日冕产生了凝血酵素显示一个钙依赖者,不平常地高(3,000 NIH U/mg ) procoagulant 活动,它对 antithrombin 释放是甚至稳定的。移开包含的 Ca < 啜 class= “ a-plus-plus ” > 在沸石的 2+ 由 antithrombin 导致释放。我们的观察建议凝血酵素活动能被无机的表面和阳离子调整。最重要地,我们的发现在蛋白质日冕和材料的 procoagulant 活动显示在 biomolecules 之间的连接,提供为沸石 hemostatics 的 procoagulant 机制的一个新分子的基础。 | Yunlong Li Xiaofeng Liao Xiaoxi Zhang Guicen Ma Shuai Zuo Liping Xiao Galen D. Stucky Zhugang Wang Xian Chen Xiaoqiang Shang Jie Fan | 2014 | Nano Research2014，7，10： | 5 |
| 6 | First experimental constraints on WIMP couplings in the effective field theory framework from CDEX显示文摘We present weakly interacting massive particles(WIMPs) search results performed using two approaches of effective field theory from the China Dark Matter Experiment(CDEX), based on the data from both CDEX-1B and CDEX-10 stages. In the nonrelativistic effective field theory approach, both time-integrated and annual modulation analyses were used to set new limits for the coupling of WIMP-nucleon effective operators at 90% confidence level(C.L.) and improve over the current bounds in the low mχregion. In the chiral effective field theory approach, data from CDEX-10 were used to set an upper limit on WIMP-pion coupling at 90% C.L. We for the first time extended the limit to the m_(χ)<6 GeV/c^(2) region. | Yi Wang Zhi Zeng Qian Yue LiTao Yang KeJun Kang YuanJing Li Mehment Agartioglu HaiPeng An JianPing Chang JingHan Chen YunHua Chen JianPing Cheng Cheng Yi Chiang WenHan Dai Zhi Deng ChangHao Fang XinPing Geng Hui Gong QiuJu Guo XuYuan Guo HongJian He Li He ShengMing He JinWei Hu TuChen Huang HanXiong Huang HaiTao Jia LiPing Jia Xi Jiang HauBin Li JianMin Li Jin Li MingXuan Li RenMingJie Li Xia Li YuLan Li Bin Liao FongKay Lin ShinTed Lin ShuKui Liu YanDong Liu Yu Liu YuanYuan Liu ZhongZhi Liu Hao Ma YuCai Mao QiYuan Nie JinHua Ning Hui Pan NingChun Qi Jie Ren XiChao Ruan ChangSong Shang Vivek Sharma Ze She Lakhwinder Singh Monoj Kumar Singh TianXi Sun ChangJian Tang WeiYou Tang Yang Tian GuangFu Wang Li Wang Qing Wang Yu Chen Wang YunXiang Wang Zhen Wang Henry Tsz-King Wong ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue YuLu Yan Nan Yi ChunXu Yu HaiJun Yu JianFeng Yue Ming Zeng BingTao Zhang Lei Zhang FengShou Zhang ZhenYu Zhang KangKang Zhao MingGang Zhao JiFang Zhou ZuYing Zhou JingJun Zhu | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，8： | 3 |
| 7 | High concentration retene and methylretene in Silurian carbonate of Michigan Basin显示文摘Retene and methylretene have been identified by gas chromatography-mass spec-trometry in aromatic hydrocarbon fractions of Silurian carbonate extracts of the Michigan Basin. Retene identified in pre-Devonian carbonates indicates that the compound not only is the biomarker of higher plants but also derived from alga or bacterium. The geochemical significance of methylretene has been discussed. | Liping Zhang Difan Huang Zhiqin Liao | 1999 | Chinese Science Bulletin1999，44，22： | 2 |
| 8 | Satellite RNA-mediated Reduction of Cucumber Mosaic Virus Genomic RNAs Accumulation in Nicotiana tabacum显示文摘卫星 RNA (satRNAs ) 是防碍助手病毒的致病的分子的寄生虫。在这研究,黄瓜马赛克的相对累积病毒(CMV )-Fny genomic RNA 与或没有 satRNAs 是 real-timeRT-PCR 分析的份量上。结果证明 satRs 显然由压抑 CMV-Fny genomic RNA 的累积在 Nicotianatabacum 上稀释了 CMV-Fny 的症状,测试同样开的读物框架。CMV-Fny 1a, 2a, 2b, 3a,和 CP 基因的 Theaccumulation 比有 satRsadded (CMV-Fsat ) 的 CMV-Fny 的高得多,在不同接种时间。 CMV-Fny Δ2 b ,在 2a 基因的C终端的完全的 2b 基因和 41amino 酸在被删除,在 N.tabacum 幼苗上引起了仅仅细微马赛克效果,类似于 CMV-Fsat 的,但是到 CMV-Fny Δ2 b 的 satRs 的增加在 CMV-Fny Δ2 b genomic RNA 的累积显示出进一步的减少。我们的结果显示由增加 satRs 或删除 2b 基因, CMV 的变细由于 CMVgenomic RNA,和在 N 的 CMV genomic RNA 累积的那调停 satRNA 的减小的低累积。tabacum 是可能与 2b 基因有关。 | Qiansheng LIAO Liping ZHU Zhiyou DU Rong ZENG Junli FENG Jishuang CHEN | 2007 | Acta Biochimica et Biophysica Sinica2007，39，3： | 2 |
| 9 | Reduced middle cingulate gyrus volume in late-onset schizophrenia in a Chinese Han population: a voxel-based structural MRI study显示文摘Dear Editor:Numerous magnetic resonance imaging(MRI)studies have demonstrated that patients with early-onset schizophrenia(EOS)have widespread structural abnormalities in the cortical gray matter[1],suggesting that neurobiological processes play a central role in the structural abnormalities underlying the pathophysiology of schizophrenia[2].In addition,volumetric abnormalities have been used to identify individuals at risk of mental states | Hong Li Jinsong Tang Liping Chen Yanhui Liao Bing Zhou Ying He Zongchang Li Luxian Lv Yi Zeng Xiaogang Chen | 2015 | Neuroscience Bulletin2015，31，5： | 2 |
| 10 | A programmed surface on polyetheretherketone for sequentially dictating osteoimmunomodulation and bone regeneration to achieve ameliorative osseointegration under osteoporotic conditions显示文摘Polyetheretherketone(PEEK)is a desirable alternative to conventional biomedical metals for orthopedic implants due to the excellent mechanical properties.However,the inherent bioinertness of PEEK contributes to inferior osseointegration of PEEK implants,especially under pathological conditions of osteoporosis.Herein,a programmed surface is designed and fabricated on PEEK to dictate osteoimmunomodulation and bone regeneration sequentially.A degradable hybrid coating consisting of poly(lactide-co-glycolide)and alendronate(ALN)loaded nano-hydroxyapatite is deposited on PEEK and then interleukin-4(IL-4)is grafted onto the outer surface of the hybrid coating with the aid of N_(2) plasma immersion ion implantation and subsequent immersion in IL-4 solution.Dominant release of IL-4 together with ALN and Ca^(2+) during the first few days synergistically mitigates the early acute inflammatory reactions and creates an osteoimmunomodulatory microenvironment that facilitates bone regeneration.Afterwards,slow and sustained delivery of ALN and Ca^(2+) in the following weeks boosts osteogenesis and suppresses osteoclastogenesis simultaneously,consequently ameliorating bone-implant osseointegration even under osteoporotic conditions.By taking into account the different phases in bone repair,this strategy of constructing advanced bone implants with sequential functions provides customizable and clinically viable therapy to osteoporotic patients. | Yanyan Zheng Ang Gao Jiaxiang Bai Qing Liao Yuzheng Wu Wei Zhang Min Guan Liping Tong Dechun Geng Xin Zhao Paul K.Chu Huaiyu Wang | 2022 | Bioactive Materials2022，7，8： | 2 |
| 11 | Current Development and Prospects of Selenium-enriched Moringa oleifera Industry in Guangxi显示文摘Due to its unique economic value,Moringa oleifera Lam. has become a tree species with great development potential. This paper firstly introduced the value of development and utilization of M. oleifera in nutrition,medicinal,industrial,greening,etc. Then,focusing on the current development status of M. oleifera industry in Guangxi and combining Guangxi's resource conditions,it came up with recommendations for the comprehensive development and rational utilization of M. oleifera. Besides,it made a prediction of the prospect of Se-enriched M.oleifera industry in Guangxi. | Panxia LIANG Yongxian LIU Guoxin SHA Liping PAN Ying XING Qing LIAO Zepu JIANG Xiu LAN Jinping CHEN Shiyang LU | 2018 | Asian Agricultural Research2018，10，6： | 2 |
| 12 | Topological Shape Changes Weaken the Innate Defensive Response to Visual Threat in Mice显示文摘Understanding the primitives of visual perception is a fundamental question in the study of vision.T o address this question,a theory of topology-based functional hierarchy in visual perception has been proposed[1,2].This theory suggests that the extraction of topological properties(TPs)serves as the starting point of object perception.The T P of a figure is the holistic identity which remains constant across various smooth shape-changing transformations of an image[2]. | Yan Huang Lei Li Kun Dong Hongsi Tang Qingning Yang Xianglian Jia Yundan Liao Wenbo Wang Zhen Ren Lin Chen Liping Wang | 2020 | Neuroscience Bulletin2020，36，4： | 2 |
| 13 | A potent PGK1 antagonist reveals PGK1 regulates the production of IL-1βand IL-6显示文摘Glycolytic metabolism enzymes have been implicated in the immunometabolism field through changes in metabolic status. PGK1 is a catalytic enzyme in the glycolytic pathway. Here, we set up a high-throughput screen platform to identify PGK1 inhibitors. DC-PGKI is an ATPcompetitive inhibitor of PGK1 with an affinity of Kd= 99.08 nmol/L. DC-PGKI stabilizes PGK1in vitro and in vivo, and suppresses both glycolytic activity and the kinase function of PGK1. In addition,DC-PGKI unveils that PGK1 regulates production of IL-1β and IL-6 in LPS-stimulated macrophages.Mechanistically, inhibition of PGK1 with DC-PGKI results in NRF2(nuclear factor-erythroid factor 2-related factor 2, NFE2L2) accumulation, then NRF2 translocates to the nucleus and binds to the proximity region of Il-1β and Il-6 genes, and inhibits LPS-induced expression of these genes. DC-PGKI ameliorates colitis in the dextran sulfate sodium(DSS)-induced colitis mouse model. These data support PGK1 as a regulator of macrophages and suggest potential utility of PGK1 inhibitors in the treatment of inflammatory bowel disease. | Liping Liao Wenzhen Dang Tingting Lin Jinghua Yu Tonghai Liu Wen Li Senhao Xiao Lei Feng Jing Huang Rong Fu Jiacheng Li Liping Liu Mingchen Wang Hongru Tao Hualiang Jiang Kaixian Chen Xingxing Diao Bing Zhou Xiaoyan Shen Cheng Luo | 2022 | Acta Pharmaceutica Sinica B2022，12，11： | 2 |
| 14 | Chitosan@Puerarin hydrogel for accelerated wound healing in diabetic subjects by miR-29ab1 mediated inflammatory axis suppression显示文摘Wound healing is one of the major global health concerns in patients with diabetes.Overactivation of pro-inflammatory M1 macrophages is associated with delayed wound healing in diabetes.miR-29ab1 plays a critical role in diabetes-related macrophage inflammation.Hence,inhibition of inflammation and regulation of miR-29 expression have been implicated as new points for skin wound healing.In this study,the traditional Chinese medicine,puerarin,was introduced to construct an injectable and self-healing chitosan@puerarin(C@P)hydrogel.The C@P hydrogel promoted diabetic wound healing and accelerated angiogenesis,which were related to the inhibition of the miR-29 mediated inflammation response.Compared to healthy subjects,miR-29a and miR-29b1 were ectopically increased in the skin wound of the diabetic model,accompanied by upregulated M1-polarization,and elevated levels of IL-1βand TNF-α.Further evaluations by miR-29ab1 knockout mice exhibited superior wound healing and attenuated inflammation.The present results suggested that miR-29ab1 is essential for diabetic wound healing by regulating the inflammatory response.Suppression of miR-29ab1 by the C@P hydrogel has the potential for improving medical approaches for wound repair. | Xiaoling Zeng Baohui Chen Luping Wang Yingxiao Sun Zhao Jin Xuanyong Liu Liping Ouyang Yun Liao | 2023 | Bioactive Materials2023，，1： | 2 |
| 15 | Puerarin@Chitosan composite for infected bone repair through mimicking the bio-functions of antimicrobial peptides显示文摘It is important to eliminate lipopolysaccharide(LPS)along with killing bacteria in periprosthetic joint infection(PJI)therapy for promoting bone repair due to its effect to regulate macrophages response.Although natural antimicrobial peptides(AMPs)offer a good solution,the unknown toxicity,high cost and exogenetic immune response hamper their applications in clinic.In this work,we fabricated a nanowire-like composite material,named P@C,by combining chitosan and puerarin via solid-phase reaction,which can finely mimic the bio-functions of AMPs.Chitosan,serving as the bacteria membrane puncture agent,and puerarin,serving as the LPS target agent,synergistically destroy the bacterial membrane structure and inhibit its recovery,thus endowing P@C with good antibacterial property.In addition,P@C possesses good osteoimmunomodulation due to its ability of LPS elimination and macrophage differentiation modulation.The in vivo results show that P@C can inhibit the LPS induced bone destruction in the Escherichia coli infected rat.P@C exhibits superior bone regeneration in Escherichia coli infected rat due to the comprehensive functions of its superior antibacterial property,and its ability of LPS elimination and immunomodulation.P@C can well mimic the functions of AMPs,which provides a novel and effective method for treating the PJI in clinic. | Liping Ouyang Baohui Chen Xingdan Liu Donghui Wang Yang Li Yun Liao Kelvin W.K.Yeung Xuanyong Liu | 2023 | Bioactive Materials2023，，3： | 1 |
| 16 | Comparative epidemiology of human infections with avian influenza A H7N9 and H5N1 viruses in China: a population-based study of laboratory-confirmed cases显示文摘 | Benjamin J Cowling Lianmei Jin Eric HY Lau Qiaohong Liao Peng Wu Hui Jiang Tim K Tsang Jiandong Zheng Vicky J Fang Zhaorui Chang Michael Y Ni Qian Zhang Dennis KM Ip Jianxing Yu Yu Li Liping Wang Wenxiao Tu Ling Meng Joseph T Wu Huiming Luo Qun Li Yuelong | 2013 | The Lancet2013，，9887： | 1 |
| 17 | Hopf bifurcation analysis of a delayed viral infection model in computer networks显示文摘 | FENG Liping LIAO Xiaofeng LI Huaqing | 2012 | Mathematical and Computer Mod- elling2012，56，78： | 1 |
| 18 | Hopf bifurcation analysis of a delayed viral infection model in computer networks显示文摘 | Feng Liping Liao Xiaofeng Li Huaqing | 2012 | Mathematical and Computer Modelling2012，56，78： | 1 |
| 19 | Hopf bifurcation analysis of a delayed viral infection model in computer networks显示文摘 | Feng Liping Liao Xiaofan Li Huaqing | 2012 | Mathematical and Computer Modelling2012，56，78： | 1 |
| 20 | Comparative epidemiology of human infections with avian influenza A H7N9 and H5N1 viruses in China: a population-based study of laboratory-confirmed cases显示文摘 | Benjamin J Cowling Lianmei Jin Eric HY Lau Qiaohong Liao Peng Wu Hui Jiang Tim K Tsang Jiandong Zheng Vicky J Fang Zhaorui Chang Michael Y Ni Qian Zhang Dennis KM Ip Jianxing Yu Yu Li Liping Wang Wenxiao Tu Ling Meng Joseph T Wu Huiming Luo Qun Li Yuelong | 2013 | The Lancet . 2013 (9887)2013，，9887： | 1 |
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