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| 1 | Neuroprotective effects of Ginkgo biloba extract and GinkgoUde B against oxygen-glucose deprivation/reoxygenation and glucose injury in a new in vitro multicellular network model显示文摘 | Xiaohan Yang Tiezheng Zheng Hao Hong Nan Cai Xiaofeng Zhou Changkai Sun Liying Wu Shuhong Liu Yongqi Zhao Lingling Zhu Ming Fan Xuezhong Zhou Fengxie Jin | 2018 | Frontiers of Medicine2018，12，3： | 12 |
| 2 | Spatial transcriptomic survey of human embryonic cerebral cortex by single-cell RNA-seq analysis显示文摘人的大脑开发的细胞的复杂性强烈地被调查了,尽管全部人的服的外皮的地区性的描述没基于单个房间的 transcriptome 分析被报导。这里,我们从人的中间怀孕期的胚胎的 22 个大脑区域在超过 4,000 个单个房间上执行了 RNA-seq。我们识别了 29 房间亚簇,它证明在每个区域和脑桥的不同比例显示出星形细胞的特别高的百分比。胚胎的神经原不象成年神经原一样多样,尽管他们在成年人拥有了他们的命运的重要特征。神经原开发是在服的外皮的 unsynchronized,当背面的区域看起来比在这个阶段的腹的区域更成熟。区域特定的基因包括地在每 neuronal 亚簇被识别,并且这些基因的一个大比例是联系的神经疾病。我们的结果介绍区域化的基因表示的一处系统的风景和人的服的外皮的神经原成熟。 | Xiaoying Fan Ji Dong Suijuan Zhong Yuan Wei Qian Wu Liying Yan Jun Yong Le Sun Xiaoye Wang Yangyu Zhao Wei Wang Jie Yan Xiaoqun Wang Jie Qiao Fuchou Tang | 2018 | Cell Research2018，28，7： | 11 |
| 3 | DNA methylation and chromatin accessibility profiling of mouse and human fetal germ cells显示文摘染色质改变为人的初发的细菌房间的 epigenetic reprogramming 是重要的。然而,全面染色质状态还没为人的胎儿的细菌房间(FGC ) 被分析了。这里,我们使用 nucleosome 占有和 methylation 定序方法在人和老鼠在胎儿的细菌房间开发期间在一系列关键时间点分析染色体宽的染色质可接近性和 DNA methylome。我们在人和老鼠 FGC 发现 116 887 和 137 557 个弄空 nucleosome 的区域(NDR ) ,盖住 germline 特定、高度有活力的规章的 genomic 元素的一个大集合,例如 enhancers。而且,我们发现远侧的 NDR 在人的 FGC 为象 NANOG , SOX17 , AP2 和 OCT4 那样的 pluripotency 和细菌房间主人管理者的有约束力的主题明确地被充实,显示在pluripotency相关的基因和细菌之间的精细的规章的平衡的存在在人的 FGC 的房间特定的基因,并且为在 vivo 的细菌房间开发的这些基因的功能的意义。我们的工作为把提供一张全面、高分辨率的路线图染色质状态转变动力学在人和老鼠 FGC 的 epigenomic reprogramming 期间。 | Hongshan Guo Boqiang Hu Liying Yan Jun Yong Yan Wu Yun Gao Fan Guo Yu Hou Xiaoying Fan Ji Dong Xiaoye Wang Xiaohui Zhu Jie Yan Yuan Wei Hongyan Jin Wenxin Zhang Lu Wen FuchouTang Jie Qiao | 2017 | Cell Research2017，27，2： | 9 |
| 4 | WIP1 Phosphatase Plays a Critical Neuroprotective Role in Brain Injury Induced by High-Altitude Hypoxic Inflammation显示文摘The hypobaric hypoxic environment in highaltitude areas often aggravates the severity of inflammation and induces brain injury as a consequence. However, the critical genes regulating this process remain largely unknown. The phosphatase wild-type p53-induced phosphatase 1(WIP1) plays important roles in various physiological and pathological processes, including the regulation of inflammation in normoxia, but its functions in hypoxic inflammation-induced brain injury remain unclear.Here, we established a mouse model of this type of injury and found that WIP1 deficiency augmented the release of inflammatory cytokines in the peripheral circulation and brain tissue, increased the numbers of activated microglia/macrophages in the brain, aggravated cerebral histological lesions, and exacerbated the impairment of motor and cognitive abilities. Collectively, these results provide the first in vivo evidence that WIP1 is a critical neuroprotector against hypoxic inflammation-induced brain injury. | Dahu Li Lijun Zhang Xin Huang Lili Liu Yunling He Lun Xu Yiyao Zhang Tong Zhao Liying Wu Yongqi Zhao Kuiwu Wu Yan Wu Ming Fan Lingling Zhu | 2017 | Neuroscience Bulletin2017，33，3： | 9 |
| 5 | Anti-apoptotic effects of aspirin following cerebral ischemia-reperfusion injury in rats显示文摘BACKGROUND:The pharmacological effects of aspirin on apoptosis are complex.The underlying mechanisms have not been properly defined.OBJECTIVE:To observe the effect of different doses of aspirin on brain cell apoptosis following focal cerebral ischemia-reperfusion injury(CIRI) in rats.DESING,TIME AND SETTING:A randomized,controlled,animal experiment,performed at the School of Medicine and Pharmaceutics,Jiangnan University between June and October 2006.MATERIALS:Twenty-six male,adult,Sprague Dawley rats(grade II),weighing 240-290 g,were obtained from Shanghai Experimental Animal Center,Chinese Academy of Sciences.Aspirin was provided by Sigma(USA).METHODS:The rats were randomly divided into four groups:sham-operation(SO),CIRI + vehicle,CIRI + aspirin(6 mg/kg),and CIRI + aspirin(60 mg/kg).Rats in the lesion groups were intragastrically administrated saline,aspirin(6 mg/kg),or aspirin(60 mg/kg),respectively.MAIN OUTCOME MEASURES:The number of pyramidal neurons with normal appearance in the cerebral cortex at 2-4 mm from the midline;apoptotic cell death as measured by TUNEL;Bcl-2 and Bax protein localization was determined by immunohistochemistry;malondialdehyde(MDA) and super oxidation(SOD) content were determined by biochemistry method;adenosine triphosphate(ATP) content measured by capillary electrophoresis.RESULTS:Following CIRI,the following parameters were altered compared with sham-operated animals:the number of neurons with normal appearance was significantly reduced in the cerebral cortex;the number of apoptotic cells increased;Bax protein expression was enhanced;and the ratio between Bcl-2 and Bax decreased.In addition,MDA content increased significantly,whereas ATP content decreased(P < 0.01).Aspirin ameliorated the loss of healthy pyramidal neurons.Both 6 and 60 mg/kg aspirin increased the ratio between Bcl-2 and Bax,with no significant difference between the treatment groups.In addition,60 mg/kg aspirin decreased MDA content and increased ATP levels.However,6 mg/kg aspirin did not have the same effect.CONCLUSION:Aspirin reduced the number of apoptotic cells following CIRI.These results suggest that the neuroprotective mechanism of aspirin could be related to elevated Bcl-2 protein levels or decreased Bax protein expression.The increase in the ratio of Bcl-2 to Bax appears to be a common anti-apoptotic mechanism of aspirin. | Liying Qiu Bin Du Ying Li Hongbin Fan Zhiyong Yang | 2008 | Neural Regeneration Research2008，3，9： | 4 |
| 6 | Phenotypic identification of peanut germplasm for resistance to southern stem rot显示文摘Southern stem rot,caused by Sclerotium rolfsii Sacc.,is a destructive soil fungal disease of peanut in China and other countries.To evaluate resistant germplasm,a total of 256 peanut accessions were investigated on their resistance to southern stem rot in 3 environments by artificial inoculation.Variance analysis indicated that disease index was significantly influenced by environment,genotype and genotypeenvironment interactions.Peanut accessions of var.vulgaris type exhibited higher resistance to southern stem rot.Disease index was significantly negatively correlated with linoleic acid content,while positively correlated with oleic acid content.Six resistant accessions were identified,including Hua 28,Shandongzai,ICG 6326,Quanhua 7,Quanhua 9 and Guihua 836,with their disease indexes under 40 and mortality were less than 30%in the three environments.The identified resistant accessions showed the great potential to be applied in resistant peanut breeding,and would be good genetic resources for enhancing the resistance to southern stem rot. | Pengmin Fan Wanduo Song Yanping Kang Liyun Wan Yong Lei Dongxin Huai Yuning Chen Xin Wang Huifang Jiang Liying Yan Boshou Liao | 2020 | Oil Crop Science2020，5，4： | 3 |
| 7 | Changes in neuronal apoptosis and apoptosis modulatory factors in cerebral ischemia/reperfusion显示文摘BACKGROUND: The high concentration of glutamate release is the main cause for neuronal cell death. The relationship between glutamate level and apoptosis during ischemia/reperfusion injury is still unclear. OBJECTIVE: To observe the neuronal apoptosis at 24 and 72 hours following cerebral ischemia/reperfusion in rats,and analyze the possible influencing factors. DESIGN: A randomized controlled animal experiment. SETTING: School of Medicine,Southern Yangtze University. MATERIALS: Totally 30 male adult Sprague Dawley (SD) rats of clean grade,weighing 240-290 g,were obtained from Shanghai Experimental Animal Center,Chinese Academy of Sciences. The rats were randomly divided into sham-operated group (n=10) and model group (n=20). Each group was observed at 24 and 72 hours after ischemia/reperfusion,5 rats at each time point in the sham-operated group,whereas 12 at 24 hours and 8 at 72 hours in the model group. Kits for determining apoptosis and Bcl-2 were bought from Wuhan Boster Biological Technology,Co.,Ltd.; Kit for calcineurin from Nanjing Jiancheng Bioengineering Institute. METHODS: The experiment was carried out in the Functional Scientific Research Room of Southern Yangtze University from June to October in 2006. ① Right middle cerebral artery was occluded by inserting a thread through internal carotid artery (ICA). The surgical process for the sham-operated rats was the same as that in the model group except a nylon suture inserted the ICA. According to Longa five-degree standard,the neurological deficit evaluation of rats was evaluated after surgery,and grades 1-3 were taken as successful model establishment. The blood was recirculated by withdrawing the nylon filament under anesthesia at 2 hours after ischemia in successful rat models. ②After reperfusion,the brain tissue was quickly removed at 24 or 72 hours and the slices were obtained from optic chiasma to funnel manubrium. The changes of the number of apoptotic cells were observed using the terminal deoxynucleotidyl transferase mediated dUTP-biotin nick-end labeling method. The expressions of Bcl-2 protein were determined with immunohistochemical staining. The activity of calcineurin was determined by the inorganic phosphorus method. The content of excitatory amino acid was detected by high performance liquid chromatography. MAIN OUTCOME MEASURES: ① Glutanate content in brain tissue; ② Conditions of apoptosis; ③ Calcineurin activity in brain tissue; ④ Bcl-2 expression in brain tissue. RESULTS: Totally 30 SD rats were used,5 died and the other 25 were involved in the analysis of results. ① Changes of apoptosis: There were 0-3 apoptotic cells in the sham-operated group. In the model group,the numbers of apoptotic cells were obviously increased at 24 and 72 hours of reperfusion (P < 0.01),and it was markedly reduced at 72 hours as compared with 24 hours (P < 0.01). ② Changes of glutanate content: The glutamate contents at 24 and 72 hours of reperfusion in the model group were obviously higher than those in the sham-operated group (P < 0.01); In the model group,it was obviously increased at 24 hours as compared with 72 hours (P < 0.01). ③ Changes of Bcl-2 protein: In the model group,the Bcl-2 protein expression had no obvious changes at 24 hours of reperfusion,and it was obviously enhanced at 72 hours,which was obviously different from that in the sham-operated group and that at 24 hours (P < 0.01). ④ Changes of calcinerin activity: In the model group,the activity of calcineurin in brain tissue had no obvious changes at 24 hours of reperfusion; The activity of calcineurin at 72 hours was obviously higher than that in the sham-operated group and that at 24 hours (P < 0.01). CONCLUSION: The brain cyto-apoptosis action at different time points following reperfusion incompletely depends on the glutamate levels,while it depends on the interaction of some apoptosis related factors,such as amino acid,calcineurin,and Bcl-2,etc. | Liying Qiu Ying Li Hongbin Fan Bin Du Zhiyong Yang Jianqing Cheng | 2007 | Neural Regeneration Research2007，2，6： | 3 |
| 8 | UWB positioning enhancement using Markov chain in indoor NLOS environment显示文摘The accuracy of the positioning system in indoor environment is often affected by none-line-of-sight(NLOS) propagation. In order to improve the positioning accuracy in indoor NLOS environment, a method used ultra-wide-band(UWB) technology, which based on time of arrival(TOA) principle, combining Markov chain and fingerprint matching was proposed. First, the TOA algorithm is used to locate the target tag. Then the Markov chain is used to identify if blocking happened and revise the position result. And the fingerprint matching is used to further improve the position accuracy. Finally, an experiment system was built to test the accuracy of the proposed method and the traditional Kalman filter method. The experimental results show that, compared with the traditional Kalman filter method, the proposed method can improve the positioning accuracy in indoor NLOS environment. | Li Shaoxian Lii Fan Wang Chengrui Hou Yanzhao | 2020 | The Journal of China Universities of Posts and Telecommunications2020，27，4： | 3 |
| 9 | Development of a Soil Stabilizer for Road Subgrade Based on Original Phosphogypsum显示文摘The research used industrial by-products original phosphogypsum(PG)as the main raw material,slag(SG)and Portland cement(PC)as auxiliary materials,and the optimal additive amount was determined according to the compressive strength value of the sample.Comprehensively evaluate the water resistance and volume stability of the samples,and determine the best formula for new roadbed stabilized materials.The results showed that when the weight ratio of PG,slag and cement was OPG:SG:PC=6:3:1,and mixed with 5%micro silica fume(MSF)and 3‰hydroxypropyl methyl cellulose(HPMC),the sample’s comprehensive performance was the best,specifically,the sample’s compressive strength in 60 days reached 28.8 MPa,the softening coefficient reached 0.9,and the expansion rate was stable at about−0.2%.In addition,the mechanism of action of enhancers MSF and HPMC was analyzed according to use Vicat device,X-ray diffractometer and scanning electron microscope.The best formula SP3GH3 has the best curing effect on soil.The 28-day unconfined compressive strength(UCS)of the sample reached 2.4 MPa,the expansion rate was less than 0.09%,and the water stability coefficient was above 0.79,which was higher than that of the samples cured by traditional cement and lime during the same period. | Zenghuan Gu Aiguo Fang Sudong Hua Qingzhou Zhao Lidong Sun Fan Xia Liying Qian Xiaojian Ren | 2021 | Journal of Renewable Materials2021，9，2： | 2 |
| 10 | Large dimensional covariance matrix estimation via a factor model显示文摘 | Fan J Fan Y Lii J | 2008 | Journal of Economet- rics2008，147，： | 1 |
| 11 | The C_(6)D_(6)detector system on the Back-n beam line of CSNS显示文摘Introduction The neutron capture cross sections are very important in the field of nuclear device design and basic physics research.Hydrogen-free liquid scintillator such as C_(6)D_(6)detectors are widely used in the neutron capture cross-sectional measurements for the low neutron sensitivity and fast time response.The Back-n white neutron source at China Spallation Neutron Source is the first spallation white neutron source in China,and it is suitable for neutron capture cross-sectional measurement.Materials and methods A C_(6)D_(6)detector system was built in the Back-n experimental station.The pulse height weighting technique was used to determine the system’s detection efficiency.The response to gamma rays of the C_(6)D_(6)detector was measured,and the energy resolution function was determined.Monte Carlo simulation with Geant4 code was carried out to get the weighting function of this C_(6)D_(6)detector system.Additionally,the systematic uncertainty of the weighting function was also determined.Conclusion According to the experimental and simulation results,this C_(6)D_(6)detector system can be used to measure neutron capture cross section. | Jie Ren Xichao Ruan Jie Bao Guangyuan Luan Wei Jiang Qi An Huaiyong Bai Ping Cao Qiping Chen Yonghao Chen Pinjing Cheng Zengqi Cui Ruirui Fan Changqing Feng Minhao Gu Fengqin Guo Changcai Han Zijie Han Guozhu He Yongcheng He Yuefeng He Hanxiong Huang Weiling Huang Xiru Huang Xiaolu Ji Xuyang Ji Haoyu Jiang Hantao Jing Ling Kang Mingtao Kang Bo Li Lun Li Qiang Li Xiao Li Yang Li Yang Li Rong Liu Shubin Liu Xingyan Liu Yinglin Ma Changjun Ning Binbin Qi Zhaohui Song Hong Sun Xiaoyang Sun Zhijia Sun Zhixin Tan Hongqing Tang Jingyu Tang Pengcheng Wang Qi Wang Taofeng Wang Yanfeng Wang Zhaohui Wang Zheng Wang Jie Wen Zhongwei Wen Qingbiao Wu Xiaoguang Wu Xuan Wu Likun Xie Yiwei Yang Han Yi Li Yu Tao Yu Yongji Yu Guohui Zhang Jing Zhang Linhao Zhang Liying Zhang Qingmin Zhang Qiwei Zhang Xianpeng Zhang Yuliang Zhang Zhiyong Zhang Yingtan Zhao Liang Zhou Zuying Zhou Danyang Zhu Kejun Zhu Peng Zhu | 2019 | Radiation Detection Technology and Methods2019，3，3： | 1 |
| 12 | Another Record: Ocean Warming Continues through 2021 despite La Nina Conditions显示文摘The increased concentration of greenhouse gases in the atmosphere from human activities traps heat within the climate system and increases ocean heat content(OHC). Here, we provide the first analysis of recent OHC changes through 2021 from two international groups. The world ocean, in 2021, was the hottest ever recorded by humans, and the 2021 annual OHC value is even higher than last year’s record value by 14 ± 11 ZJ(1 zetta J = 1021 J) using the IAP/CAS dataset and by16 ± 10 ZJ using NCEI/NOAA dataset. The long-term ocean warming is larger in the Atlantic and Southern Oceans than in other regions and is mainly attributed, via climate model simulations, to an increase in anthropogenic greenhouse gas concentrations. The year-to-year variation of OHC is primarily tied to the El Nino-Southern Oscillation(ENSO). In the seven maritime domains of the Indian, Tropical Atlantic, North Atlantic, Northwest Pacific, North Pacific, Southern oceans,and the Mediterranean Sea, robust warming is observed but with distinct inter-annual to decadal variability. Four out of seven domains showed record-high heat content in 2021. The anomalous global and regional ocean warming established in this study should be incorporated into climate risk assessments, adaptation, and mitigation. | Lijing CHENG John ABRAHAM Kevin ETRENBERTH John FASULLO Tim BOYER Michael EMANN Jiang ZHU Fan WANG Ricardo LOCARNINI Yuanlong LI Bin ZHANG Zhetao TAN Fujiang YU Liying WAN Xingrong CHEN Xiangzhou SONG Yulong LIU Franco RESEGHETTI Simona SIMONCELLI Viktor GOURETSKI Gengxin CHEN Alexey MISHONOV Jim REAGAN | 2022 | Advances in Atmospheric Sciences2022，39，3： | 1 |
| 13 | Hypoxia-ischemic encephalopathy in full-term neonate: correlation proton MR spectroscopy with MR imaging显示文摘 | Guoguang Fan Zhenhua Wu Liying Chen Qiyong Guo Binbin Ye Jian Mao | 2002 | European Journal of Radiology2002，，： | 1 |
| 14 | Genome Analyses of Single Human Oocytes显示文摘 | Yu Hou Wei Fan Liying Yan Rong Li Ying Lian Jin Huang Jinsen Li Liya Xu Fuchou Tang X. Sunney Xie Jie Qiao | 2013 | Cell2013，，7： | 1 |
| 15 | Macrophages in tumor microenvironments and the progression of tumors显示文摘 | Hao NB Lii MH Fan YH | 2012 | Clin Dev Immunol2012，2012，94： | 1 |
| 16 | Ki-netics of thermite reaction in Al-Fe203 system 显示文摘 | Fan Runhua Lii Hongliang Sun Kangning | 2005 | Thermochimica Acta2005，440，2： | 1 |
| 17 | PTBP1 promotes IRES-mediated translation of cyclin B1 in cancer显示文摘Cyclin B1 is an essential cyclin-dependent protein that involves in the G2/M transition.Multiple studies report that cyclin B1 is upregulated in cancers and promotes cancer progression.However,the mechanism of cyclin B1 upregulation remains unclear.Here we report that the 5′UTR of cyclin B1 mRNA contains an internal ribosome entry site(IRES)by using a bicistronic fluorescent reporter.We show that IRES can initiate the translation of cyclin B1,and the IRES-mediated translation is further activated under cell stress.Interacting trans-acting factors(ITAFs)are required by most IRES to initiate the translation.We find that PTBP1 promotes the IRES-mediated translation of cyclin B1 by binding to the 5′UTR of cyclin B1.On top of that,PTBP1 promotes the malignancy of ESCC cells.Our data suggest that the IRES-mediated translation of cyclin B1 plays an essential role in the cyclin B1 upregulation in cancers. | Xinyi Fan Zitong Zhao Liying Ma Xuanlin Huang Qimin Zhan Yongmei Song | 2022 | Acta Biochimica et Biophysica Sinica2022，54，5： | 1 |
| 18 | Genome Analyses of Single Human Oocytes显示文摘 | Yu Hou Wei Fan Liying Yan Rong Li Ying Lian Jin Huang Jinsen Li Liya Xu Fuchou Tang X. Sunney Xie Jie Qiao | 2013 | Cell2013，，7： | 1 |
| 19 | Dissecting Human Gonadal Cell Lineage Specification and Sex Determination Using A Single-cell RNA-seq Approach显示文摘Gonadal somatic cells are the main players in gonad development and are important for sex determination and germ cell development.Here,using a time-series single-cell RNA sequencing(scRNA-seq)strategy,we analyzed fetal germ cells(FGCs)and gonadal somatic cells in human embryos and fetuses.Clustering analysis of testes and ovaries revealed several novel cell subsets,including POU5F1^(+)SPARC^(+)FGCs and KRT19^(+) somatic cells.Furthermore,our data indicated that the bone morphogenetic protein(BMP)signaling pathway plays cell type-specific and developmental stage-specific roles in testis development and promotes the gonocyte-to-spermatogonium transition(GST)in late-stage testicular mitotic arrest FGCs.Intriguingly,testosterone synthesis function transitioned from fetal Sertoli cells to adult Leydig cells in a stepwise manner.In our study,potential interactions between gonadal somatic cells were systematically explored and we identified cell type-specific developmental defects in both FGCs and gonadal somatic cells in a Turner syndrome embryo(45,XO).Our work provides a blueprint of the complex yet highly ordered development of and the interactions among human FGCs and gonadal somatic cells. | Rui Wang Xixi Liu Li Li Ming Yang Jun Yong Fan Zhai Lu Wen Liying Yan Jie Qiao Fuchou Tang | 2022 | Genomics, Proteomics & Bioinformatics2022，20，2： | 1 |
| 20 | Wnt/β-catenin signaling induces the transcription of cystathionine-γ-lyase, a stimulator of tumor in colon cancer显示文摘 | Kun Fan Na Li Jingjing Qi Peng Yin Chao Zhao Liying Wang Zengxia Li Xiliang Zha | 2014 | Cellular Signalling2014，，： | 1 |
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