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| 1 | Cluster analysis for syndromes of real-world coronary heartdisease with angina pectoris显示文摘Syndromes of coronary heart disease with angina pectoris were analyzed to provide guidance forclinical practice and to improve accuracy of traditional Chinese medicine (TCM) diagnoses and efficacy of TCMtreatment. A total of 860 cases with coronary heart disease with angina pectoris were selected from TCM ClinicalResearch Information Sharing System for TCM clinics and research. Syndromes were automatically extractedwith the cluster method and were analyzed to provide objective evidence for clinical studies. Final syndromeclassifications were recognized and confirmed by clinical experts. Popular syndromes included Qi and blooddeficiency, blood stasis and obstruction collaterals, liver depression and spleen deficiency, and Qi stagnation andblood stasis. Syndromes Qi and blood deficiency and blood stasis and obstruction collaterals accounted for 28.61%of total syndromes, whereas liver depression and spleen deficiency and Qi stagnation and blood stasis accountedfor 26.44%. The main syndrome elements comprised Qi deficiency, blood deficiency, blood stasis, and Qistagnation. | Yufeng Zhao Xueyun Yu Xinyu Cao Lin Luo Liyun He Shusong Mao Li Ma Peijing Rong Yuxue Zhao Guozheng Li Baoyan Liu | 2018 | Frontiers of Medicine2018，12，5： | 28 |
| 2 | Reducing the radiation dose with the adaptive statistical iterative reconstruction technique for chest CT in adults: a parameter study显示文摘 | Liu Wenyun Ding Xiaobo Kong Boyu Fan Baoyan Chen Liang | 2014 | Chinese Medical Journal2014，，7： | 15 |
| 3 | Comparsion analysis of data mining models applied to clinical research in Traditional Chinese Medicine显示文摘OBJECTIVE: To help researchers selecting appropriate data mining models to provide better evidence for the clinical practice of Traditional Chinese Medicine(TCM) diagnosis and therapy.METHODS: Clinical issues based on data mining models were comprehensively summarized from four significant elements of the clinical studies:symptoms, symptom patterns, herbs, and efficacy.Existing problems were further generalized to determine the relevant factors of the performance of data mining models, e.g. data type, samples, parameters, variable labels. Combining these relevant factors, the TCM clinical data features were compared with regards to statistical characters and informatics properties. Data models were compared simultaneously from the view of applied conditions and suitable scopes.RESULTS: The main application problems were the inconsistent data type and the small samples for the used data mining models, which caused the inappropriate results, even the mistake results. These features, i.e. advantages, disadvantages, satisfied data types, tasks of data mining, and the TCM issues, were summarized and compared.CONCLUSION: By aiming at the special features of different data mining models, the clinical doctors could select the suitable data mining models to resolve the TCM problem. | Yufeng Zhao Qi Xie Liyun He Baoyan Liu Kun Li Xiang Zhang Wenjing Bai Lin Luo Xianghong Jing Ruili Huo | 2014 | Journal of Traditional Chinese Medicine2014，34，5： | 14 |
| 4 | A Global Identification and Analysis of Small Nucleolar RNAs and Possible Intermediate-Sized Non-Coding RNAs in Oryza sativa显示文摘积累的证据建议非编码的 RNA (ncRNAs ) 在许多真核细胞的有机体普遍、机能上地重要。在这研究,我们采用了分别和 cDNA 图书馆构造方法列在后面由的一种特殊尺寸 454 系统地介绍米饭的深定序中间尺寸的 ncRNAs。我们的分析总共导致了 1349 ncRNAs 的鉴定,包括一个未知功能的范畴的 754 新奇 ncRNAs。所有识别 ncRNAs 的染色体分发没显示出海滨偏爱,并且显示了类似于与很少染色体相关性在编码蛋白质的基因观察了那的一个模式。非常, ncRNAs 的一半被集中在附近编码区域的 5 和 3 个终点正海滨。新奇 ncRNAs 的多数是米饭特定,当 78% 小核仁的 RNA (snoRNAs ) 被保存时。双人脚踏车复制驾驶了扩大在 snoRNA 基因家庭的一半上。而且, 90% snoRNA 候选人被显示特别地生产在 2030 nt,其 80% 通常与淘金者蛋白质被联系,和 AGO1b 之间的小 RNA。总的来说,我们的调查结果在 monocot 种提供中间尺寸的非编码的 transcriptome 的一个全面看法,它将为 ncRNA 函数的深入的分析用作一个有用平台。 | Ting-Ting Liu Danmeng Zhu Wei Chen Wei Deng Hang He Guangming He Baoyan Bai Yijun Qi Runsheng Chen Xing Wang Deng | 2013 | Molecular Plant2013，6，3： | 10 |
| 5 | Efficacy evaluation of summer acupoint application treatment on asthma patients: a two-year follow-up clinical study显示文摘OBJECTIVE: To evaluate the self-efficacy and satisfaction of asthma patients subjected to summer acupoint application treatment(SAAT).METHODS: A two-year follow-up clinical study was conducted. Patients with asthma were treated by applying a herbal paste onto the Feishu(BL 13) and Fengmen(BL 12) acupoints on the three hottest days of summer, according to the traditional Chinese calendar, from 2008 to 2010. During a two-year follow-up, these patients were asked tofill out a questionnaire evaluating asthma degree,exacerbation frequency, concomitant medications and self-satisfaction. The self-rate and doctor-report outcomes obtained in parallel were evaluated to assess the efficacy of SAAT.RESULTS: A total of 527 asthma patients were initially enrolled in this study, of which 97 elderly patients and those with more severe cases of asthma were lost to follow-up. Thus, a total of 430 patients were valid for analysis using self-rate data. Nevertheless, occasional negative returns were obtained;almost all of the outcomes were rated as 'No change', 'Moderate effective', or 'Very effective'. In addition, 80% of the patients were satisfied with this treatment. Moreover, 391(91.4%) patients were somewhat improved after SAAT in 2009, and further improvement was observed in 2010. After SAAT, the average asthma-degree score decreased from 5.3 in 2008 to 4 in 2009 and, subsequently to3.5 in 2010.CONCLUSION: With pronounced patient satisfaction, SAAT can reduce the exacerbation severity and frequency, concomitant medications and asthma degree. Prolonging the treatment course might enhance the efficacy of SAAT. | Wu Xiaqiu Peng Jin Li Guoqin Zhang Wei Liu Guangxia Liu Baoyan | 2015 | Journal of Traditional Chinese Medicine2015，35，1： | 7 |
| 6 | Influencing factors on efficacy of summer acupoint application treatment for allergic rhinitis:a retrospective study显示文摘OBJECTIVE:Allergic rhinitis(AR) is a common health problem.Summer acupoint application treatment(SAAT) is reported to effectively treat and prevent AR from seasonal onset.In the present study,we aimed to evaluate its effects,especially on the course of AR,through a retrospective study.METHOD:A cross-sectional multicenter study was performed based on patients treated between 2008 and 2009 in 13 clinical centers in China.A total of 1058 outpatients aged ≥2 years with documented AR and ≥1 year SAAT were eligible for enrollment.A case report form(CRF) was completed by both patient and doctor.The CRF was designed to collect data on the patient's history of SAAT,AR condition,and self-reported health condition.The outcomes(dependent variables) were incidence and intensity of AR and concomitant medications used.Data were analyzed with ordinal logistic regression(OLR).RESULTS:Treatment course and seasonal pattern of AR were related to all dependent variables positively.After controlling for sample bias and confounding factors,the findings suggested that a 3-year treatment course had better efficacy(OR/incidence of AR:2.57,95%CI:1.76-3.76;OR/intensity of AR:2.17,95%CI:1.50-3.17;OR/concomitant medications:2.20,95% CI:1.50-3.23) compared with a 2-year or less treatment course.CONCLUSION:The results showed that:1)the length of treatment course was positively associated with the efficacy of SAAT(the longer the treatment course,the better the efficacy);and 2)SAAT was more efficacious in treating seasonal AR than non-seasonal AR. | Jin Peng Xiaqiu Wu Jingqing Hu Yigong Fang Mingjie Zi Baoyan Liu | 2012 | Journal of Traditional Chinese Medicine2012，32，3： | 7 |
| 7 | Clinical phenotype network: the underlying mechanism for perso- nalized diagnosis and treatment of traditional Chinese medicine显示文摘繁体中文药(TCM ) 在个性化的药的一个典型纲要调查临床的诊断和治疗整齐,它意味着有一样的疾病的个性化的病人将从不同 TCM 医生获得不同诊断和最佳的治疗。这个原则被 TCM 临床的专业人员认出并且粘住几千年了。然而,个性化的药不是的 TCM 的内在的机制到目前为止充分调查了并且仍然保持未知。这份报纸讨论 TCM 的框架在经典文学并且在真实世界的临床的背景的个性化的药,并且调查 TCM 的内在的机制从网络药的观点的个性化的药。在失眠上基于 246 个设计得好的门诊病人记录,由评估表明观察的个人偏爱和植物药方的偏爱,我们注意了每张植物药方的重要类似和每相遇的症状类似。为了调查 TCM 的内在的机制,个性化药,我们构造了一个临床的显型网络(CPN ) ,在哪个临床的显型实体喜欢症状并且诊断作为连接表现为在这些实体之间的节点和关联。这 CPN 被用来调查症候群和症状的同现的混杂的边界。小世界的拓扑的特征与高聚类结构在 CPN 被注意,它在 TCM 的合理性上提供卓见个性化的诊断和处理。这个网络上的调查将帮助我们在 TCM 的内在的机制上获得理解个性化的药并且将为 TCM 的精炼建议一个新观点个性化的临床的技巧。 | Xuezhong Zhou Yubing Li Yonghong Peng Jingqing HU Runshun Zhang Liyun He Yinghui Wang Lijie Jiang Shiyan Yan Peng Li Qi Xie Baoyan Liu | 2014 | Frontiers of Medicine2014，8，3： | 7 |
| 8 | Clinical features and the traditional Chinese medicine therapeutic characteristics of 293 COVID-19 inpatient cases显示文摘Coronavirus disease 2019 (COVID-19) is now pandemic worldwide and has heavily overloaded hospitals in Wuhan City, China during the time between late January and February. We reported the clinical features and therapeutic characteristics of moderate COVID-19 cases in Wuhan that were treated via the integration of traditional Chinese medicine (TCM) and Western medicine. We collected electronic medical record (EMR) data, which included the full clinical profiles of patients, from a designated TCM hospital in Wuhan. The structured data of symptoms and drugs from admission notes were obtained through an information extraction process. Other key clinical entities were also confirmed and normalized to obtain information on the diagnosis, clinical treatments, laboratory tests, and outcomes of the patients. A total of 293 COVID-19 inpatient cases, including 207 moderate and 86 (29.3%) severe cases, were included in our research. Among these cases, 238 were discharged, 31 were transferred, and 24 (all severe cases) died in the hospital. Our COVID-19 cases involved elderly patients with advanced ages (57 years on average) and high comorbidity rates (61%). Our results reconfirmed several well-recognized risk factors, such as age, gender (male), and comorbidities, as well as provided novel laboratory indications (e.g., cholesterol) and TCM-specific phenotype markers (e.g., dull tongue) that were relevant to COVID-19 infections and prognosis. In addition to antiviral/antibiotics and standard supportive therapies, TCM herbal prescriptions incorporating 290 distinct herbs were used in 273 (93%) cases. The cases that received TCM treatment had lower death rates than those that did not receive TCM treatment (17/273= 6.2% vs. 7/20= 35%, P = 0.0004 for all cases;17/77= 22% vs. 7/9= 77.7%, P = 0.002 for severe cases). The TCM herbal prescriptions used for the treatment of COVID-19 infections mainly consisted of Pericarpium Citri Reticulatae, Radix Scutellariae, Rhizoma Pinellia, and their combinations, which reflected the practical TCM principles (e.g., clearing heat and dampening phlegm). Lastly, 59% of the patients received treatment, including antiviral, antibiotics, and Chinese patent medicine, before admission. This situation might have some effects on symptoms, such as fever and dry cough. By using EMR data, we described the clinical features and therapeutic characteristics of 293 COVID-19 cases treated via the integration of TCM herbal prescriptions and Western medicine. Clinical manifestations and treatments before admission and in the hospital were investigated. Our results preliminarily showed the potential effectiveness of TCM herbal prescriptions and their regularities in COVID-19 treatment. | Zixin Shu Yana Zhou Kai Chang Jifen Liu Xiaojun Min Qing Zhang Jing Sun Yajuan Xiong Qunsheng Zou Qiguang Zheng Jinghui Ji Josiah Poon Baoyan Liu Xuezhong Zhou Xiaodong Li | 2020 | Frontiers of Medicine2020，14，6： | 7 |
| 9 | Discussion of solutions to ethical issues in real-world study显示文摘在最近的年里,真实世界的学习(RWS ) 的范例在世界范围的临床的研究的最前线,特别地在繁体中文药的领域里。在这篇论文,真实世界的临床的研究的基本特征和性质被讨论,并且在 RWS 的不同阶段的道德的问题被提出并且考察。而且,这些问题的一些初步的答案例如在 RWS 的过程期间保护题目并且执行道德的评论,基于最近的惯例和基本道德的规则被介绍改进科学有效性和 RWS 的道德的水平。 | Sicheng Wang Baoyan Liu Ningning Xiong Qi Xie Runshun Zhang Xuezhong Zhou Jie Qiao | 2014 | Frontiers of Medicine2014，8，3： | 6 |
| 10 | Utilizing big data to build personalized technology and system of diagnosis and treatment in traditional Chinese medicine显示文摘 | Baoyan Liu | 2014 | Frontiers of Medicine2014，8，3： | 6 |
| 11 | Clinical data quality problems and countermeasure for real world study显示文摘真实世界学习(RWS ) 为临床的研究成为了一个热点。数据质量在研究成就和另外的临床的研究领域起一个重要作用。在这篇论文,在繁体中文药的 RWS 的普通优秀问题被讨论,并且一项反措施被建议。 | Runshun Zhang Yinghui Wang Baoyan Liu Guangli Song Xuezhong Zhou Shizhen Fan Xishui Pan | 2014 | Frontiers of Medicine2014，8，3： | 6 |
| 12 | Development of a disease-specific health-related quality of life questionnaire for patients with post-stroke spasticity显示文摘OBJECTIVE:This study was designed to develop a disease-specific health-related quality of life(HR-QOL) measure for patients with post-stroke spasticity.METHODS:Based on responses from 20 patients with post-stroke spasticity and an extensive literature search,items potentially used to measure these patients' recovery status were identified and the Apoplexy Spastic-Paralysis Questionnaire(ASPQ) was formed.A sample of 106 patients was then tested twice using the ASPQ,the Self-rating Depression Scale(SDS) and the Stroke-specific Quality of Life(SS-QOL).Clinicians also examined all the patients using the Ashworth Scale(AS).Internal reliability was assessed using Cronbach's coefficient α,while construct validity was determined using principal component analysis(PCA).Empirical validity was evaluated between patients with depression and those without depression by single factor analysis.Sensitivity was examined by calculating the Spearman correlation coefficient between the changes in scores of the ASPQ,the AS and the SS-QOL.RESULTS:The ASPQ had adequate internal consistency reliability(α=0.874) and sensitivity,with significant correlations between the changes in scores of the AS,the SS-QOL and the ASPQ,with three domains.In a construct validity test,six factors were extracted;the overall variance explained by all factors was 72.6%.For empirical validity,mean values of 19 items and 3 domains were all higher in the depressive patients than in the non-depressive patients.CONCLUSION:The ASPQ is a reliable and valid self-rating scale for measuring the HR-QOL in patients with post-stroke spasticity. | Yanhong Zhang Baoyan Liu Zhishun Liu Yin Wang Hong Zhao Mingjie Zi Liping Wang Hong Liu Zhen Chen Ying Xie | 2012 | Journal of Traditional Chinese Medicine2012，32，4： | 5 |
| 13 | Multistage analysis method for detection of effective herb prescription from clinical data显示文摘为特定的疾病条件或特别的耐心的组决定有效繁体中文药(TCM ) 治疗是因为复杂个性化的表明,在真实世界的病人和在临床的背景规定的个性化的联合治疗要求调查的一个困难的问题。在这研究,集成倾向大小写匹配的一个多级式的分析方法,复杂网络分析,和植物给了丰富分析被建议为特别疾病识别有效植物药方(例如,失眠) 。首先,匹配的倾向大小写被使用匹配临床的盒子。然后,核心网络抽取和植物集合丰富被联合检测核心有效植物药方。基于有效性的相互的信息被用来检测强壮的 herbsymptom 关系。这个方法在一个 TCM 临床的数据集合上被使用, 955 个病人从设计得好的观察研究收集了。结果与更高的有效性率揭示了那组植物药方(76.9% 对 42.8% 为匹配的样品;94.2% 对 84.9% 为所有样品) 与原版相比,药方被发现。有症状表明的特别的耐心的组也被识别帮助调查有效植物药方的指示。 | Kuo Yang Runshun Zhang Liyun He Yubing Li Wenwen Liu Changhe Yu Yanhong Zhang Xinlong Li Yan Liu Weiming Xu Xuezhong Zhou Baoyan Liu | 2018 | Frontiers of Medicine2018，12，2： | 5 |
| 14 | Inverse kinematics model of parallel macro-micro manipulator system显示文摘An improved design, which employs the integration of optic, mechanical and electronic technologies for the next generation large radio telescope, is presented in this note. The authors propose the concept of parallel macro-micro manipulator system from the feed support structure with a rough tuning subsystem based on a cable structure and a fine tuning subsystem based on the Stewart platform. According to the requirement of astronomical observation, the inverse kinematics model of this parallel macro-micro manipulator system is deduced. This inverse kinematics model is necessary for the computer-controlled motion of feed. | WANG Wenli DUAN Baoyan LIU Hong NAN Rendong PENG Bo | 2000 | Chinese Science Bulletin2000，45，24： | 4 |
| 15 | Dynamics of algae growth and nutrients in experimental enclosures culturing bighead carp and common carp: Phosphorus dynamics显示文摘This is the third paper of the series about 'Dynamics of algae growth and nutrients in experimental enclosures culturing bighead carp and common carp'.In this paper,phosphorus dynamics were investigated under the condition of culturing bighead carp and common carp with added fish food(nitrogen dynamics is discussed in the second paper because their behaviors are so different from each other).Nearly fifty days' observation results indicated that the reservoir water was typical of 'phosphorus limited' water,and soluble reactive phosphorus(SRP) was the main constituent of measured total phosphorus(TP).The presence of fish food resulted in significantly higher SRP,dissolved total phosphorus(DTP) and TP concentrations in contrast with the reservoir water.Moreover,continuous supply of fish food led to the decline of total nitrogen to total phosphorus(TN:TP) from more than 100 to less than5.Variations in the ratio of TN to TP favored the growth of blue-green algae.Fish species affected phosphorus concentrations,and culturing bait-eating common carp contributed more to reducing the SRP,DTP and TP concentrations than culturing planktivorous bighead carp.0.5%,4.1%and 3.1%TP can be removed in enclosures with culturing bighead carp,common carp and mixed bighead carp and common carp,respectively.Abundant phosphorus in the fish culturing activities may be present as the uneaten food,algae cells,and within the water column and sediment,which should be taken into serious consideration for the target of future water eutrophication prevention and safety of the drinking water supply. | Suiliang Huang Min Wu Changjuan Zang Shenglan Du Joseph Domagalski Magdalena Gajewska Feng Gao Chao Lin Yong Guo Baoyan Liu Shaoming Wang Yang Luo Adam Szymkiewicz Romuald Szymkiewicz | 2016 | International Journal of Sediment Research2016，31，2： | 3 |
| 16 | Phosphorylation of a wheat aquaporin at two sites enhances both plant growth and defense显示文摘Eukaryotic aquaporins share the characteristic of functional multiplicity in transporting distinct substrates and regulating various processes,but the underlying molecular basis for this is largely unknown.Here,we report that the wheat(Triticum aestivum)aquaporin TaPIP2;10 undergoes phosphorylation to promote photosynthesis and productivity and to confer innate immunity against pathogens and a generalist aphid pest.In response to elevated atmospheric CO_(2)concentrations,TaPIP2;10 is phosphorylated at the serine residue S280 and thereafter transports CO_(2)into wheat cells,resulting in enhanced photosynthesis and increased grain yield.In response to apoplastic H_(2)O_(2) induced by pathogen or insect attacks,TaPIP2;10 is phosphorylated at S121 and this phosphorylated form transports H_(2)O_(2) into the cytoplasm,where H_(2)O_(2)intensifies host defenses,restricting further attacks.Wheat resistance and grain yield could be simultaneously increased by TaPIP2;10 overexpression or by expressing a TaPIP2;10 phosphomimic with aspartic acid substitutions at S121 and S280,thereby improving both crop productivity and immunity. | Kai Lu Xiaochen Chen Xiaohui Yao Yuyan An Xuan Wang Lina Qin Xiaoxu Li Zuodong Wang Shuo Liu Zhimao Sun Liyuan Zhang Lei Chen Baoyan Li Baoyou Liu Weiyang Wang Xinhua Ding Yonghua Yang Meixiang Zhang Shenshen Zou Hansong Dong | 2022 | Molecular Plant2022，15，11： | 2 |
| 17 | The role of fluorescent carbon dots in crops:Mechanism and applications显示文摘Fluorescent carbon dots(CDs)have been widely studied in biosensing,imaging,information encryption,and optoelectronic devices due to excellent optical properties,such as photostability,tunable luminescence range,and resistance to photobleaching.In recent years,CDs have been explored for use in agriculture.Based on their light harvest and light conversion capacity,as well as their characteristics of easy synthesis and low toxicity,CDs show great potential in improving crop photosynthesis.In addition,CDs can also be used for smart and anticounterfeiting packing,food safety detection,and preservation of crops after harvest.In this study,the application of CDs with excellent optical properties in crops has been summarized,including preharvest processes(photosynthesis and plant imaging),and postharvest processes(crop preservation and food safety).Then the toxicity of CDs to crops is introduced.Finally,the present challenges and future prospects are discussed. | Baoyan Guo Guo Liu Haopeng Wei Jiemin Qiu Jianle Zhuang Xuejie Zhang Mingtao Zheng Wei Li Haoran Zhang Chaofan Hu Bingfu Lei Yingliang Liu | 2022 | SmartMat2022，3，2： | 2 |
| 18 | Scientific computation of big data in real-world clinical research显示文摘大数据时代的来临为繁体中文药(TCM ) 创造机会和挑战。这研究关于 TCM 的科学计算描述研究的起源,概念,涵义,和价值。它也在真实世界的、临床的科学研究的范例的指导下面讨论科学,技术,和药的集成。TCM 临床的诊断,治疗,和知识传统地被限制到文学和感觉层次;然而,主要方法被用来把他们变换成统计,例如特征子集优化,学习的多标签,和基于复杂性,智力,数据,和计算科学的复杂网络的方法。而且,这些方法在在个性化的临床的诊断和处理,以及在与如此的诊断和处理有关的决策当模特儿和各种各样的复杂关系的分析被使用。因此,这些方法强烈支持 TCM 的真实世界的临床的研究范例。 | Guozheng Li Xuewen Zuo Baoyan Liu | 2014 | Frontiers of Medicine2014，8，3： | 2 |
| 19 | Interactions between alkali/surfactant/polymer and their effects on emulsion stability显示文摘 | Kang Wanli Liu Yi Qi Baoyan Liao Guangzhi Yang Zhenyu Hong Jichun | 2000 | Colloids and Surfaces A: Physicochemical and Engineering Aspects2000，，1： | 2 |
| 20 | A novel classification method for aid decision of traditional Chinese patent medicines for stroke treatment显示文摘 | Yufeng Zhao Bo Liu Liyun He Wenjing Bai Xueyun Yu Xinyu Cao Lin Luo Peijing Rong Yuxue Zhao Guozheng Li Baoyan Liu | 2017 | Frontiers of Medicine2017，11，3： | 2 |
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