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| 1 | Effects of Short-Term Forest Bathing on Human Health in a Broad-Leaved Evergreen Forest in Zhejiang Province,China显示文摘Objective To investigate the effects of short-term forest bathing on human health.Methods Twenty healthy male university students participated as subjects and were randomly divided into two groups of 10.One group was sent on a two-night trip to a broad-leaved evergreen forest,and the other was sent to a city area.Serum cytokine levels reflecting inflammatory and stress response,indicators reflecting oxidative stress,the distribution of leukocyte subsets,and plasma endothelin-1 (ET-1) concentrations were measured before and after the experiment to evaluate the positive health effects of forest environments.A profile of mood states (POMS) evaluation was used to assess changes in mood states.Results No significant differences in the baseline values of the indicators were observed between the two groups before the experiment.Subjects exposed to the forest environment showed reduced oxidative stress and pro-inflammatory level,as evidenced by decreased malondialdehyde,interleukin-6,and tumor necrosis factor α levels compared with the urban group.Serum cortisol levels were also lower than in the urban group.Notably,the concentration of plasma ET-1 was much lower in subjects exposed to the forest environment.The POMS evaluation showed that after exposure to the forest environment,subjects had lower scores in the negative subscales,and the score for vigor was increased.Conclusion Forest bathing is beneficial to human health,perhaps through preventive effects related to several pathological factors. | MAO Gen Xiang LAN Xiao Guang CAO Yong Bao CHEN Zhuo Mei HE Zhi Huat LV Yuan Dong WANG Ya Zhen HU Xi Lian WANG Guo Fu YAN Jing | 2012 | Biomedical and Environmental Sciences2012，25，3： | 20 |
| 2 | Calcium-binding ability of soy protein hydrolysates显示文摘This present study investigated the ability of various soy protein hydrolysates(SPHs)in binding calcium.It was demonstrated that the amount of Ca-bound depended greatly on the SPHs obtained using different proteases,which included:neutrase, flavourzyme,protease M and pepsin.The maximum level of Ca-bound(66.9 mg/g)occurred when protease M was used to hydrolyze soy protein.Peptide fragments exhibiting high Ca-binding capacity had molecular weights of either 14.4 or 8-9 kDa.The level of Ca-bound increased linearly with the increment of carboxyl content in SPHs,and further deamidation on SPHs from protease M improved Ca-binding of the hydrolysate. | Xiao Lan Bao Mei Song Jing Zhang Yang Chen Shun Tang Guo | 2007 | Chinese Chemical Letters2007，18，9： | 14 |
| 3 | Ionic liquid based dispersive liquid-liquid microextraction of aromatic amines in water samples显示文摘In this work,a new microextraction method termed ionic liquid based dispersive liquid-liquid microextraction(IL-DLLME) was demonstrated for the extraction of 2-methylaniline,4-chloroaniline,1-naphthylamine and 4-aminobiphenyl in aqueous matrices.After extraction the ionic liquid(IL)phase was injected directly into the high performance liquid chromatography(HPLC) system for determination.Some parameters that might affect the extraction efficiency were optimized.Under the optimum conditions,good linear relationship,sensitivity and reproducibility were obtained.The limits of detection(LOD,S/N=3)for the four analytes were in the range of 0.45-2.6μg L^(-1).The relative standard deviations(R.S.D.,n=6)were in the range of 6.2-9.8%. This method was applied for the analysis of the real water samples.The recoveries ranged from 93.4 to 106.4%.The main advantages of the method are high speed,high recovery,good repeatability and volatile organic solvent-free. | Yun Chang Fan Zheng Liang Hu Mei Lan Chen Chao Shen Tu Yan Zhu | 2008 | Chinese Chemical Letters2008，19，8： | 13 |
| 4 | Malnutrition and Quality of Life in Chinese Cancer Patients: a Clinical Study of 23,994 Subjects显示文摘Background Malnutrition is common in patients with cancer,and can negatively impact their quality of life(QoL)and even survival.However,there is currently no large data available on the prevalence of malnutrition in Chinese cancer patients.This study evaluated the prevalence of malnutrition and the QoL of Chinese patients with locoregional,recurrent or metastatic cancer.Methods We conducted a nationwide observational,multi-center,hospital-based cross-sectional study within the Chinese Society of Nutritional Oncology(CSNO)Network.All of the patients were diagnosed with one of the following 18 different types of malignant tumors:lung cancer,gastric cancer,liver cancer,colorectal cancer,breast cancer,esophageal cancer,cervical cancer,endometrial cancer,nasopharyngeal carcinoma,malignant lymphoma,leukemia,pancreatic cancer,ovarian cancer,prostate cancer,bladder cancer,brain cancer,biliary tract malignant tumors or gastrointestinal stromal tumors.These patients were enrolled from 72 hospitals located in different regions of China.The patients’nutritional status was evaluated based on the body mass index(BMI),loss of bodyweight,laboratory measurements and patient generated-subjective global assessment(PG-SGA)scores.The cancer patients’physical status and QoL were assessed by the Karnofsky Performance Status(KPS)questionnaire and the European Organization for Research and Treatment of Cancer(EORTC)QLQ-C30 questionnaire,respectively.Results From December 2013 to April 2016,23,994 patients hospitalized for cancer treatment(such as surgery,chemotherapy or radiotherapy)were enrolled in the study.The patients included 12,494(52.9%)males and 11,124(47.1%)females.The mean age was 55.8±13.7 years.The proportions of patients in cancer stagesⅠ,Ⅱ,Ⅲ,Ⅳand uncertain were 11.5%,20.3%,27.5%,30.2%and 10.5%,respectively.Among the 23,994 inpatients,the proportions of patients who were underweight(BMI<18.5 kg/m2),normal(18.5 kg/m2 | Hong Xia Xu Chun Hua Song Zhen Ming Fu Chang Wang Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Fu Xiang Zhou Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Min Weng Qing Hua Yao Jiu Wei Cui Wei Li Han Ping Shi the Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group | 2021 | Journal of Nutritional Oncology2021，6，1： | 8 |
| 5 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 6 | Validity of the Chinese Version of the Patient-Generated Subjective Global Assessment (PG-SGA) in Lung Cancer Patients显示文摘The prevalence of malnutrition is high among oncology patients in China. Although the Patient- Generated Subjective Global Assessment (PG-SGA) is widely recognized as an important nutritional assessment tool, it has not been validated for Chinese cancer patients. The purpose of this study was to conduct an analysis of nutrition screening and assessment data to validate the Chinese version of the PG-SGA in Chinese patients with lung cancer. This was an observational, cross-sectional study of 2,000 consecutive adult patients with lung cancer treated at several tertiary hospitals in China. Anthropometric and patient descriptive data were collected. The PG-SGA generated a score for the nutritional risk and a global rating for the nutritional status. The internal consistency, external consistency, and construct validity were evaluated, and a known-groups comparison and principal component analyses were conducted to evaluate the reliability and validity of the PG-SGA. The known-groups comparison demonstrated the ability of the PG-SGA to differentiate lung cancer patients of different nutritional and body mass index (BMI) groups. A confirmatory factor analysis supported the original four-factor structure of the PG-SGA. In terms of the internal and external consistency, the PG-SGA demonstrated intra-class correlation coefficients (ICC) up to 0.987. Alternative form validity was also demonstrated between Box 4 of the PG-SGA and the Karnofsky Performance Status score, with excellent external consistency (r = 0.972, P < 0.001). The construct validity was supported, and selected questionnaire dimensions were evident in the principal component analysis. Significant Spearman correlations (P < 0.001) were demonstrated. The Chinese version of the PG-SGA demonstrated significant reliability and sufficient exploratory properties to support its validity. It seems to be a valid tool that can be used to access the nutritional status of Chinese lung cancer patients. The validity of the PG-SGA in Chinese cancer patients warrants further investigation in other cancer types. | Zhen Ming Fu Hong Xia Xu Chun Hua Song Wei Li Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Chang Wang Han Ping Shi The Investigation on Nutrition Status and Clinical Outcome of Common Cancers (INSCOC) Group | 2016 | Journal of Nutritional Oncology2016，1，1： | 7 |
| 7 | Origin of Listwanite in the Luobusa Ophiolite,Tibet,Implications for Chromite Stability in Hydrothermal Systems显示文摘Listwanite from the Luobusa ophiolite,Tibet,forms a narrow,discontinuous band along the eastern part of the southern boundary fault. We undertook a detailed petrographic and geochemical study to understand the mineral transformation processes and the behaviour of major and trace elements during listwanite formation. Three alteration zones characterized by distinct mineral components and texture are recognized and,in order of increasing degree of alteration,these are: zoneIII is rich in serpentine minerals; zoneII is rich in talc and carbonates; and zoneI is mainly composed of carbonates and quartz. Geochemical data for the three alteration zones show significant modification of some major and trace elements in the protolith,although some oxides show linear correlations with Mg O. Gold mineralization is recognized in the Luobusa listwanite and may signify an important target for future mineral exploration. Gold enrichment occurs in both zoneI and zoneIIand is up to 0.91 g/t in one sample from zoneI. We show that CO2-rich hydrothermal fluids can modify both the occurrence and composition of chromite grains,indicating some degree of chromite mobility. Low-Cr anhedral grains are more easily altered than high-Cr varieties. The compositions of chromite and olivine grains in the listwanite suggest a dunite protolith. | ZHANG Lan YANG Jingsui Paul T.ROBINSON XIONG Fahui CHEN Yanhong LAI Shengmin CHEN Mei | 2015 | Acta Geologica Sinica(English Edition)2015，89，2： | 6 |
| 8 | Geochronology and Geochemistry of the Subduction-related Rocks with High Sr/Y Ratios in the Zedong Area: Implications for the Magmatism in Southern Lhasa Terrane during Late Cretaceous显示文摘南部的拉萨岩层以它在中生代和新生代期间记录 magmatism 的巨大的 magmatic 带著名。尽管在南部的拉萨岩层的中生代大陆人边缘背景被识别了,在迟了的白垩纪期间的这构造设定和进化历史的细节仍然保持不清楚。为了推进,抑制这些问题,我们现在的锆石 LA-ICP-MS U-Pb,同位素的 Hf 和 Sangri 的 Gongbari dacites 的 geochemical 数据组织哪个从南部的拉萨岩层的东方部分由古新的 granodiorites 侵入了,西藏。新年龄数据显示 dacites 在 ∼95.4 妈被产生,它建议 Sangri 组火山作用可以持续到迟了的白垩纪。Gongbari dacites 被高 Sr 428-758 ppm 内容描绘,例如 Yb=0.78-1.14 ppm 的重稀土元素元素和 Y 的低集中;有高 Sr/Y 41.91-67.59 和 La/Yb 22.64-30.64 比率的 Y=8.85-11.4 ppm,类似于那些 adakite。岩石是计算碱的, metaluminous,在 LILE 充实,在 HFSE 弄空,并且有积极 ε Hf t 价值 +7.7 到 +11.6。Gongbari dacites 被到石榴石角闪岩外形条件的在角闪岩下面的年轻、热的 subducted Neo-Tethyan 海洋的外壳的部分融化可能生产。尽管 Gangdese 山可能形成了以前 Indo 亚洲的碰撞,拉萨岩层的南部的边缘可能不通过显然外壳的变厚在期间向北方 Neo-Tethyan 的 subduction 海洋的岩石圈。 | CHEN Yanhong YANG Jingsui XIONG Fahui ZHANG Lan LAI Shengmin CHEN Mei | 2015 | Acta Geologica Sinica(English Edition)2015，89，2： | 6 |
| 9 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 10 | Validity of the Chinese Version of the Patient-Generated Subjective Global Assessment (PG-SGA) in Gastric Cancer Patients显示文摘Purpose Malnutrition is severe among gastric cancer patients in China. While the Patient-Generated Subjective Global Assessment (PG-SGA) is a widely used nutritional assessment tool, the validation for Chinese patients with gastric cancer has not been performed yet. The aim of this research is to validate the Chinese version of the PGSGA in Chinese gastric cancer patients by conducting analyses of nutrition screening and assessment data. Methods Two thousand consecutive adult patients with gastric cancer were included in this observational, cross-sectional study in several tertiary hospitals in China. A survey was made among those patients, which included several questionnaires and some anthropometric parameters. We calculated the parameters to validate the use of PG-SGA categorizing the nutritional status of gastric cancer patients. Then we performed statistical analysis to evaluate the internal consistency, external consistency, and construct validity. Results This study verified the ability of the PG-SGA to differentiate gastric cancer patients into different nutritional groups. The confirmatory factor analysis verified the original four-factor structure of the PG-SGA. The internal and external consistency was measured by a concordance analysis which showed an intraclass correlation coefficients (ICC) of 0.987. The correlations of the Box 4 score with the Karnofsky performance status score demonstrated alternative form validity with good external consistency (Pearson, r = 0.643, P < 0.001). All three anthropometric dimensions of the PG-SGA were supported by principal component analysis. Spearman correlations (P < 0.001) were significant in the majority of tests. Conclusion The Chinese version of the PG-SGA is a valid tool to access the patients’ nutritional status for Chinese gastric patients. | Zhen Ming Fu Hong Xia Xu Chun Hua Song Wei Li Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Chang Wang Han Ping Shi The Investigation on Nutrition Status and Clinical Outcome of Common Cancers (INSCOC) Group | 2018 | Journal of Nutritional Oncology2018，3，4： | 5 |
| 11 | 乳腺导管内增生性病变及合并浸润性导管癌的临床病理分析(英文)显示文摘Objective:The purpose of this study was to study the clinical and pathological characteristics of breast intraductal proliferative lesions(IDPLs) and associated with invasive breast cancer.Methods:We reviewed 327 cases of breast intraductal proliferative lesions including 53 cases of usual ductal hyperplasia,57 cases of atypical ductal hyperplasia,89 cases of ductal carcinoma in situ,and 128 cases coexist with invasive ductal carcinomas.Cases of pure invasive cancer without intraductal proliferative lesions were excluded.The mult IDPLs biological parameters including the express of ER,PR,HER2,HIF-1α and Ki-67 detected by immunohistochemistry S-P method(n=327) and the levels of CA153,TSGF,CA125 and CEA both in nipple discharge and serum(n=179) measured with Electrochemiluminescence method and their relationship were studied,and 30 cases of normal pregnant women were compared with.Results:A single histologic subtype was present in 49.85%(163/327) of the cases,two subtypes in 33.03%(108/327),and three in 17.13%(56/327).The most common subtypes present were cribriform(43.12%,141/327) and solid(38.53%,126/327),while the comedo(16.35%,54/327),and micropapillary(12.84%,42/327) subtypes were less common.Comedo and solid were frequently found together for coexpression as were micropapillary and papillary subtypes.However,Comedo subtype was much less likely to be found with papillary,cribriform or micropapillary subtypes.Additionally,comedo subtypes tend to be hormone receptor negative,Her2 positive and high-grade while the cribriform and solid subtype tends to be hormone receptor positive,Her2 negative and low grade.Papillary subtype was least likely to be associated with an invasive cancer.Furthermore,the nipple discharge and serum levels of CA153,TSGF,CA125 and CEA in coexist with invasive ductal carcinomas patients were significantly higher than those in the benign breast disease(pure intraductal proliferative lesions) and normal pregnant women(P<0.01).Additionally,the levels of CA153,TSGF,CA125 and CEA in nipple discharge were significantly higher than in the serum(P<0.01),and had a positive correlation with the Ki-67,grade,clinical stage,lymph node metastasis and tumor recurrence(P<0.05),and negative correlation with the level of ER and PR(P<0.05).The sensitivity of the four serum tumor markers in combination was only 69.77%,in contrast,the combined detection both in discharge and serum was 97.67%,and the negative predictive value was 99.03%.The sensitivity of combined detection both in nipple discharge and serum were significantly higher than other detection(P<0.05).Conclusion:IDPLs often present more than one histologic subtype and the most common subtypes are cribriform and solid,while comedo and micropapillary subtypes are less common.Our results suggest that the levels of CA153,TSGF,CA125 and CEA in nipple discharge were significantly higher than those in the serum,and is associated with HIF-1α.The aberration of HIF-1α may play a key role during oncogenesis and promote breast cellular transformation into malignancy,a finding useful for further understanding of tumorigenesis.Nipple discharge can be the earliest presenting symptom of breast cancer.The dynamic combined detection of the four tumor markers both in nipple discharge and serum are helpful to the stratification of preoperative patients and benefit to better prewarning markers for monitoring their recurrence and metastasis and clinical staging of tumors in clinic,but cannot increase the sensitivity of judging the patients with early breast cancer. | Gangping Wang Hong Zhang Zuofeng Zhang Yun'ai Liang Ying Chen Lan Mei | 2013 | The Chinese-German Journal of Clinical Oncology2013，12，12： | 4 |
| 12 | Mineralization of HA crystals regulated by terephthaloyl chloride-modified silk fibroin films显示文摘Terephthaloyl 氯化物(DB ) 修改了丝绸丝心蛋白(SF ) 电影被沉浸进乘模仿的身体液体(1.5 SBF ) 的 1.5 调整 hydroxyapatite 的矿化作用(哈) 在大约 36.5 点的晶体 ? 吗?? | Rong Li Guang Mei Chen Xin Lan Ma Qiao Yan Chen Ge Wen Xu Yi Ping Huang | 2011 | Chinese Chemical Letters2011，22，9： | 4 |
| 13 | Lateral Flow Immunoassay for Quantitative Detection of Ractopamine in Swine Urine显示文摘A strip reader based lateral flow immunoassay(LFIA)was established for the rapid and quantitative detection of ractopamine(RAC)in swine urine.The ratio of the optical densities(ODs)of the test line(AT)to that of the control line(AC)was used to effectively minimize interference among strips and sample variations.The linear range for the quantitative detection of RAC was0.2 ng/mL to 3.5 ng/mL with a median inhibitory concentration(IC50)of 0.59±0.06 ng/mL.The limit of detection(LOD)of the LFIA was 0.13 ng/mL.The intra-assay recovery rates were 92.97%,97.25%,and 107.41%,whereas the inter-assay rates were80.07%,108.17%,and 93.7%,respectively. | REN Mei Ling CHEN Xue Lan LI Chao Hui XU Bo LIU Wen Juan XU Heng Yi XIONG Yong Hua | 2014 | Biomedical and Environmental Sciences2014，27，2： | 3 |
| 14 | Extension Protocol for the Investigation on Nutrition Status and Clinical Outcome of Patients with Common Cancers in China(INSCOC)Study:2021 update显示文摘Background Malnutrition is common in patients with cancer,and this adversely affects the survival and quality of life of patients.Chinese Society for Nutritional Oncology issued a multi-center,large-scale,long-term follow-up prospective study,the Investigation on Nutrition Status and Clinical Outcome of Patients with Common Cancers in China(INSCOC study)since 2013.This is an extension to the previous 2013-2020 study protocol.This study still sought to:①address the prognostic impact of nutritional factors and quality of life on cancer patient survival;②describe the overall and cancer-specific incidence and/or distribution of malnutrition and different measurements of patient quality of life.Methods and study design This is an observational,multi-centered,hospital-based prospective cohort study.Data collection will be performed at baseline(within 48 hours after patient admission),during the hospital stay and 30 days after hospital admission.Follow-up will be conducted for 1-20 years after enrollment.The primary outcome will be the all-cause mortality/overall survival,and secondary outcomes will be the length of hospital stay and costs of hospitalization.Study factors will include demographic characteristics,tumor characteristics,information about chronic diseases,hematological measurements(e.g.,red blood cell count,total lymphocyte counts,hemoglobin,albumin,prealbumin,creatinine,C-reactive protein,IL-6),anthropometric measurements(e.g.,height,weight,arm circumference,arm muscle circumference,triceps skinfold thickness,and waist circumference),body composition parameters,PG-SGA scores,quality of life(as indicated by the QLQ-C30 questionnaire),muscle mass(as indicated by the calf circumference),muscle strength(as indicated by the handgrip strength),muscle function(as indicated by the six-meter walking speed test)and physical status assessments(as indicated by the Karnofsky Performance Status scores).This clinical study protocol was approved by local Ethics Committees of all the participating hospitals.Written informed consent is required for each subject included.Discussion This multi-center,large-scale,long-term follow up prospective study will help improve the diagnosis of malnutrition in cancer patients and identify the risk factors associated with adverse clinical outcomes.The anticipated results of this study will highlight the need for a truly scientific appraisal of nutrition therapy in Chinese oncology populations,and finally help treat the potentially reversible elements of malnutrition in cancer patients to improve their clinical outcomes in the future. | Hong Xia Xu Chun Hua Song Liang Yu Yin Chang Wang Zhen Ming Fu Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Fu Xiang Zhou Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Zhi Kang Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Xiang Hua Wu Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Min Weng Qing Hua Yao Ya Yin Yu Quan Jun Lyu Hong Qiu Ming Liu Wei Li Han Ping Shi The Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group | 2022 | Journal of Nutritional Oncology2022，7，2： | 3 |
| 15 | Antibody neutralization to SARS-CoV-2 and variants after 1 year in Wuhan,China显示文摘Most COVID-19 convalescents can build effective anti-SARS-CoV-2 humoral immunity,but it remains unclear how long it can maintain and how efficiently it can prevent the reinfection of the emerging SARS-CoV-2 variants.Here,we tested the sera from 248 COVID-19 convalescents around 1 year post-infection in Wuhan,the earliest known epicenter.SARS-CoV-2 immunoglobulin G(IgG)was well maintained in most patients and potently neutralizes the infection of the original strain and the B.1.1.7 variant.However,varying degrees of immune escape was observed on the other tested variants in a patient-specific manner,with individuals showing remarkably broad neutralization potency.The immune escape can be largely attributed to several critical spike mutations.These results suggest that SARS-CoV-2 can elicit long-lasting immunity but this is escaped by the emerging variants. | Qianyun Liu Qing Xiong Fanghua Mei Chengbao Ma Zhen Zhang Bing Hu Junqiang Xu Yongzhong Jiang Faxian Zhan Suhua Zhou Li Tao Xianying Chen Ming Guo Xin Wang Yaohui Fang Shu Shen Yingle Liu Fang Liu Li Zhou Ke Xu Changwen Ke Fei Deng Kun Cai Huan Yan Yu Chen Ke Lan | 2022 | The Innovation2022，3，1： | 3 |
| 16 | Myelin Deficits Caused by Olig2 Deficiency Lead to Cognitive Dysfunction and Increase Vulnerability to Social Withdrawal in Adult Mice显示文摘Oligodendrocyte (OL) and myelin development are crucial for network integration and are associated with higher brain functions. Accumulating evidence has demonstrated structural and functional impairment of OLs and myelin in serious mental illnesses. However, whether these deficits contribute to the brain dysfunction or pathogenesis of such diseases still lacks direct evidence. In this study, we conditionally deleted Olig2 in oligodendroglial lineage cells (Olig2 cKO) and screened the behavioral changes in adult mice. We found that Olig2 ablation impaired myelin development, which further resulted in severe hypomyelination in the anterior cingulate cortex. Strikingly, Olig2 cKO mice exhibited an anxious phenotype, aberrant responses to stress, and cognitive deficits. Moreover, Olig2 cKO mice showed increased vulnerability to social avoidance under the mild stress of social isolation. Together,these results indicate that developmental deficits in OL and myelin lead to cognitive impairment and increase the risk of phenotypes reminiscent of mental illnesses. | Xianjun Chen Fei Wang Jingli Gan Zhonghua Zhang Xuejun Liang Tao Li Nanxin Huang Xiaofeng Zhao Feng Mei Lan Xiao | 2020 | Neuroscience Bulletin2020，36，4： | 3 |
| 17 | Prediction models of long‐term Cirrhosis and hepatocellular carcinoma risk in chronic hepatitis B patients: Risk scores integrating host and virus profiles显示文摘 | Mei‐Hsuan Lee Hwai‐I. Yang Jessica Liu Richard Batrla‐Utermann Chin‐Lan Jen Uchenna H. Iloeje Sheng‐Nan Lu San‐Lin You Li‐Yu Wang Chien‐Jen Chen | 2013 | Hepatology2013，，2： | 3 |
| 18 | Determination of sulfur anions by ion chromatography-postcolumn derivation and UV detection显示文摘A novel method for determination of formaldehyde sulfoxylate,sulfite,thiocyanate,and thiosulfate in foodstuffs by ion chromatography separation with postcolumn derivation and UV detection has been developed.All species are separated at Dionex IonPac AG22A and AS22A with mobile phase of a mixture of 4.5 mmol/L sodium carbonate and 0.8 mmol/L sodium bicarbonate at a flow-rate of 1.0mL/min.The postcolumn derivation solution was 0.24%iodine in 0.2%phosphate acid and the detection wavelength was set at 288 nm.The detection limits(LOD,signal-to-noise ratio of 3) of formaldehyde sulfoxylate,sulfite, thiocyanate,and thiosulfate were 0.004,0.006,0.006,and 0.007 mg/L,respectively.Within-day relative standard deviations(RSD, n = 10) of formaldehyde sulfoxylate,sulfite,thiocyanate,and thiosulfate were 3.24%,3.76%,2.68%,and 2.07%,respectively.The recoveries of the four anions were in the range of 67.2-116.5%. | Mei Lan Chen Ming Li Ye Xue Ling Zeng Yun Chang Fan Zhu Yan | 2009 | Chinese Chemical Letters2009，20，10： | 2 |
| 19 | Hepatitis C virus genotype 1b increases cumulative lifetime risk of hepatocellular carcinoma显示文摘 | Mei‐Hsuan Lee Hwai‐I Yang Sheng‐Nan Lu Chin‐Lan Jen San‐Lin You Li‐Yu Wang Gilbert L’Italien Chien‐Jen Chen Yong Yuan | 2014 | Cancer2014，，5： | 1 |
| 20 | Cross-sectional surveys and subtype classification of human Blastocystis isolates from four epidemiological settings in China显示文摘 | Lan Hua Li Xiao Ping Zhang Shan Lv Ling Zhang Hisao Yoshikawa Zhiliang Wu Peter Steinmann Jürg Utzinger Xiao Mei Tong Shao Hong Chen Xiao Nong Zhou | 2007 | Parasitology Research2007，，1： | 1 |
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