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| 1 | Sensitivity of green and blue-green algae to methyl tert-butyl ether显示文摘The toxicity of methyl tert-butyl ether (MTBE) to Chlorella ellipsoidea and Aphanizomenon flos-aquae was tested and assessed for a 15-d incubation with concentrations of MTBE from high (2.00×104 mg/L) to low (2 mg/L). The results showed that the toxicity was low when the concentration of MTBE was in the range 1.00×104-2.00×104 mg/L (the greatest inhibition of growth-rate was 70%-71%, occurred during the day 1-5). Low concentrations (2-500 mg/L) stimulated algal growth up to the greatest effect of 85%-200% when the concentration of MTBE was 50-100 mg/L during day 3-5. The toxicity of MTBE (72-120 h EC50) was 6.65×103-9.58×103 mg/L for C. ellipsoidea and that is 1.14×104-2.00×104 mg/L for A. floc-aquae. We found that the toxicity and ecological risk of MTBE for the algal community structure were low and the toxicity was influenced by the duration time of the test. | CHEN Jianmeng MA Jianyi CAO Wei WANG Pinwei TONG Senmiao SUN Yizhao | 2009 | Journal of Environmental Sciences2009，21，4： | 5 |
| 2 | Effects of Epidural Spinal Cord Stimulation and Treadmill Training on Locomotion Function and Ultrastructure of Spinal Cord Anterior Horn after Moderate Spinal Cord Injury in Rats显示文摘Objective:To investigate the effects of epidural spinal cord stimulation(ESCS) and treadmill training on the locomotion function and ultrastructure of spinal cord anterior horn after moderate spinal cord injury in rats.Method:Nine adult female Sprague-Dawley rats were randomly distributed into three groups:①spinal cord injury group(SI,n=3).②spinal cord injury plus ESCS group(SE,n=3).③spinal cord injury plus treadmill training group(TT,n=3).All rats received a moderate spinal cord injury surgery.Four weeks after surgery,rats in SE group received an electrode implantation procedure,with the electrode field covering spinal cord segments L2-S1.Four weeks after electrode implantation,rats received subthreshold ESCS for 30 min/d.Rats in TT group received 4cm/s treadmill training for 30min/d.Rats in SI group received no intervention,as a control group.All procedures in these three groups lasted four weeks.The open field Basso,Beattie and Bresnahan(BBB) scale was used before and after intervention to evaluate rats' hindlimb motor function.Result:After four weeks intervention,rats in TT group improved their open field locomotion scores to 20.In contrast,no significant improvement was observed in groups SI and SE.The morphology of synapses and neurons were similar regardless of whether rats had undergone ESCS,treadmill training or not.Conclusion:ESCS alone was not sufficient to improve the walking ability of spinal cord injured rats.ESCS or treadmill training alone might not contribute to the changes of ultrastructure in anterior horn of spinal cord that underlie the recovery of walking ability.Further research is needed to understand the contributions of combination of ESCS and treadmill training to the rehabilitation of spinal cord injured rats. | WANG Yizhao HUANG Xiaolin XU Jiang XU Tao FANG Zhengyu XU Qi TU Xikai YANG Peipei | 2009 | 中国康复医学杂志2009，24，6： | 4 |
| 3 | Jugular arginine supplementation increases lactation performance and nitrogen utilization efficiency in lactating dairy cows显示文摘Background: Enhancing the post-ruminal supply of arginine(Arg), a semi-essential amino acid(AA), elicits positive effects on milk production. Our objective was to determine the effects of Arg infusion on milk production parameters and aspects of nitrogen(N) absorption and utilization in lactating dairy cows. Six lactating Chinese Holstein cows of similar body weight(508 ± 14 kg), body condition score(3.0 ± 0), parity(4.0 ± 0), milk yield(30.6 ±1.8 kg) and days in milk(20 ± 2 d) were randomly assigned to 3 treatments in a replicated 3 × 3 Latin square design with 21 d for each period(1 week for infusion and 2 weeks for washout). Treatments were 1) Control: saline;2) Arg group: saline + 9.42 g/L L-Arg;3) Alanine(Ala) group: saline + 19.31 g/L L-Ala(iso-nitrogenous to the Arg group). Milk production and composition, dry matter intake, apparent absorption of N, profiles of amino acids(AA) in blood,urea N in urine, milk, and blood, and gene expression of AA transporters were determined.Results: Compared with the Control or Ala group, the infusion of Arg led to greater expression of AA transporters(SLC7 A2 and SLC7 A8) and apparent uptake of free AA in the mammary gland, and was accompanied by greater milk yield, milk protein yield and milk efficiency(calculated by dividing milk yield over feed intake), together with lower concentration of urea N [regarded as an indicator of N utilization efficiency(NUE)] in blood and milk. Furthermore, in the cows infused with Arg, the NUE was higher and the concentration of urea N in urine was lower than those in the Ala group, although no differences were detected in NUE and urea N in urine between the Control and Arg group.The infusion of Ala had no effect on those indices compared with the Control.Conclusions: Overall, enhancing the post-ruminal supply of Arg via the jugular vein had a positive effect on the synthesis of milk protein at least in part by increasing gene expression of some AA transporters and uptake of free AA by mammary gland. | Luoyang Ding Yizhao Shen Yifan Wang Gang Zhou Xin Zhang Mengzhi Wang Juan J.Loor Lianmin Chen Jun Zhang | 2019 | Journal of Animal Science and Biotechnology2019，10，2： | 3 |
| 4 | Tibetan tectonic evolution inferred from spatial and temporal variations in post-collisional magmatism显示文摘 | Sun-Lin Chung Mei-Fei Chu Yuquan Zhang Yingwen Xie Ching-Hua Lo Tung-Yi Lee Ching-Ying Lan Xianhua Li Qi Zhang Yizhao Wang | 2004 | Earth Science Reviews2004，，3： | 2 |
| 5 | Direct conversion of mouse astrocytes into neural progenitor cells and specific lineages of neurons显示文摘Background:Cell replacement therapy has been envisioned as a promising treatment for neurodegenerative diseases.Due to the ethical concerns of ESCs-derived neural progenitor cells(NPCs)and tumorigenic potential of iPSCs,reprogramming of somatic cells directly into multipotent NPCs has emerged as a preferred approach for cell transplantation.Methods:Mouse astrocytes were reprogrammed into NPCs by the overexpression of transcription factors(TFs)Foxg1,Sox2,and Brn2.The generation of subtypes of neurons was directed by the force expression of cell-type specific TFs Lhx8 or Foxa2/Lmx1a.Results:Astrocyte-derived induced NPCs(AiNPCs)share high similarities,including the expression of NPC-specific genes,DNA methylation patterns,the ability to proliferate and differentiate,with the wild type NPCs.The AiNPCs are committed to the forebrain identity and predominantly differentiated into glutamatergic and GABAergic neuronal subtypes.Interestingly,additional overexpression of TFs Lhx8 and Foxa2/Lmx1a in AiNPCs promoted cholinergic and dopaminergic neuronal differentiation,respectively.Conclusions:Our studies suggest that astrocytes can be converted into AiNPCs and lineage-committed AiNPCs can acquire differentiation potential of other lineages through forced expression of specific TFs.Understanding the impact of the TF sets on the reprogramming and differentiation into specific lineages of neurons will provide valuable strategies for astrocyte-based cell therapy in neurodegenerative diseases. | Kangmu Ma Xiaobei Deng Xiaohuan Xia Zhaohuan Fan Xinrui Qi Yongxiang Wang Yuju Li Yizhao Ma Qiang Chen Hui Peng Jianqing Ding Chunhong Li Yunlong Huang Changhai Tian Jialin C.Zheng | 2018 | Translational Neurodegeneration2018，7，1： | 2 |
| 6 | Astrocytic effect of low molecular weight heparin-superoxide dismutase conjugate in interleukin-6 overexpressing mice following local cerebral ischemia显示文摘BACKGROUND:Studies have shown that low molecular weight heparin-superoxide dismutase conjugate exhibits a remarkable neuroprotective effect. OBJECTIVE:To investigate the effect of low molecular weight heparin-superoxide dismutase conjugate on astrocytes in an interleukin-6(IL-6) overexpressing mice following local cerebral ischemia. DESIGN,TIME AND SETTING:Randomized,cytological,controlled,animal study was performed in the Department of Physiology and Neuroscience,Neurology and Biochemistry and Molecular Biology,Medical University of South Carolina from January 2005 to March 2005. MATERIALS:Nine IL-6 transgenic mice,irrespective of gender,were randomly divided into three groups:sham-operated,model,and treatment,with three mice in each group.With exception of the sham-operated group,right middle cerebral artery occlusion was induced in the mice. Expression of glial fibrillary acidic protein,an astrocyte marker,was determined by immunohistochemistry.Low molecular weight heparin-superoxide dismutase conjugate was purchased from Biochemistry and Biotechnique Institute,Shandong University. METHODS:Two minutes prior to ischemia induction,0.5 mL/kg saline or 20 000 U/kg low molecular weight heparin-superoxide dismutase conjugate were administrated via the femoral artery in the model group and treatment group,respectively.The sham-operated group underwent the same protocols,with the exception of occlusion and treatment. MAIN OUTCOME MEASURES:The number of glial fibrillary acidic protein-positive cells was quantified under light microscopy(x200). RESULTS:In the sham-operated group,there were a large number of astrocytes in the IL-6 transgenic mice.However,the cell bodies were small,and the branches were few and thin.The number of astrocytes in the model group was remarkably less than the sham-operated group. Compared to the model and sham-operated groups,the number of astrocytes significantly increased,and the cell body became larger,following treatment with low molecular weight heparin-superoxide dismutase conjugate.Astrocytes exhibited hypertrophy and hyperplasia,and the processes became longer and thicker. CONCLUSION:The low molecular weight heparin-superoxide dismutase conjugate may provide neuroprotection through astrocytic activation at the super-early stage of cerebral ischemia and reperfusion. | Yizhao Li Guixiang Cui Qingde Wang Hongxia Liu Xiaoxia Zhang Fengshan Wang Keqin Xie | 2009 | Neural Regeneration Research2009，4，2： | 1 |
| 7 | Parallelized upwind flux splitting scheme for supersonic reacting flows on unstructured hybrid meshes显示文摘 | WANG Jiangfeng WU Yizhao | 2007 | Transactions of Naniing University of Aeronautics and Astronautics2007，24，3： | 1 |
| 8 | Numerical simulation of spray atomization in supersonic flows 显示文摘 | Jiangfeng Wang Chen Liu And Yizhao Wu | 2010 | Modem Physics Let- ters B2010，13，24： | 1 |
| 9 | Thermodynamic analysis and optimization of a solar-powered transcritical CO 2 power cycle for reverse osmosis desalination based on the recovery of cryogenic energy of LNG显示文摘 | Guanghui Xia Qingxuan Sun Xu Cao Jiangfeng Wang Yizhao Yu Laisheng Wang | 2013 | Energy2013，，： | 1 |
| 10 | Numerical simul- ation of spray atomization in supersonic flows显示文摘 | Wang Jiangfeng Liu Chen Wu Yizhao | 2010 | Modem Physics Letters B2010，24，13： | 1 |
| 11 | Remarkable improvement of cyclic stability in Li-O2 batteries using ruthenocene as a redox mediator显示文摘Nonaqueous Li-O2 batteries attract attention for their theoretical specific energy density.However,due to the difficulty of decomposition of Li2 O2,Li-O2 batteries have high charge overpotential and poor cycling life.So all kinds of catalysts have been studied on the cathode.Compared to heterogeneous solid catalysts,soluble catalysts achieve faster and more effective transport of electrons by reversible redox pairs.Here,we first report ruthenocene(Ruc) as a mobile redox mediator in a Li-O2 battery.0.01 mol/L Ruc in the electrolyte effectively reduces the charging voltage by 610 mV.Additionally,Ruc greatly increases the cycling life by four-fold(up to 83 cycles) with a simple ketjen black(KB) cathode.The results of SEM,XPS and XRD confirm that less discharge product residue accumulated after recharge.To verify the reaction mechanisms of the mediato r,free energy profiles of the possible reaction pathways based on DFT are provided. | Cuicui Zhu Yiping Wang Ling Shuai Yizhao Tang Ming Qiu Jian Xie Jia Liu Wen Wen Hengquan Chen Suifei Nan Mei Dou Qinggang He | 2020 | Chinese Chemical Letters2020，31，7： | 1 |
| 12 | cAMP-PGC1α途径诱导的抗Warburg效应驱动胶质母细胞瘤细胞分化为星形胶质细胞显示文摘文章简介多形性胶质母细胞瘤(GBM)是人类最具侵袭性的肿瘤之一。虽然分化治疗已被提出作为治疗GBM的潜在方法,但诱导分化的机制仍然很不清楚。在此,课题组利用c AMP激活剂建立了GBM诱导分化模型,该模型特异性地指导GBM分化为星形胶质细胞。 | Fan Xing Yizhao Luan Jing Cai Sihan Wu Jialuo Mai Jiayu Gu Haipeng Zhang Kai Li Yuan Lin Xiao Xiao Jiankai Liang Yuan Li Wenli Chen Yaqian Tan Longxiang Sheng Bingzheng Lu Wanjun Lu Mingshi Gao Pengxin Qiu Xingwen Su Wei Yin Jun Hu Zhongping Chen Ke Sai Jing Wang Furong Chen Yinsheng Chen Shida Zhu Dongbing Liu Shiyuan Cheng 谢志 朱文博 颜光美 | 2018 | 科学新闻2018，0，4： | 1 |
| 13 | A Randomized trial comparing ticlopidine with aspirin fof the prevention of ischemic cerebral stroke显示文摘OBJECTIVE To assess the effect and cafety of t iclopidine in the prevention of ischemic cerebral stroke and to compare theeffect of low-dose aspirin with t iclopidine. BACKGROUND The effect and safety of ticlopidine irn the prevention of ischemic cerebral stroke in China has not been reported. METHODS 329 patients with TIA or mild ischemic cevebral stroke wasrandonmly assigned to ticlopidine group(165 case) or aspirin group (164 case) in this study.These patrents were randomly allocated to receive either 250mg trclopidine or 50mg aspirin daily and didnd take any other platelet antiaggregating drugs. Time of eacn follow up visit was one to two months. Follow up lasted for 6 to 18 months. RESULTS The event rate for stroke or death from any cause was 8.3% in ticlopidine group arid 14.9% in aspirin group. This repesented a risk reduction of 44.3%(95% cofidence interval, 0.29-0.94) for ticiopidine group as compared with aspirin group. The event raite for ischemic cerebral stroke or myocarction of ticlopidine group(7.0%)was lower than that cf aspirin group(14.8%)(P<0.05).A riskreduction of 52.7%(95% confidence interval,0.24-0.92) for ticlopidine group compared with aspirin group. The rate of adverse effects of ticlopidine group and aspirin group were 6.9% and 11.0% during the trial ,but this was not statistically significant(P<0.05).DISCUSSION and CONCLUSION Therapeutic efficacy for the prevention oi ischemic stroke of ticlopidine was better than that of aspirin, the rate of side effects in ticlopidine group and aspirin group are not statistically significant. So ticiopidine could serve as a first-line drug for the prevention of ischemic stroke. | Li Yizhao Li Danian Wang Lei | 2000 | 中国临床神经科学2000，8，z1： | 0 |
| 14 | The phage T4 DNA ligase mediates bacterial chromosome DSBs repair as single component non-homologous end joining显示文摘DNA double-strand breaks(DSBs)are one of the most lethal forms of DNA damage that is not efficiently repaired in prokaryotes.Certain microorganisms can handle chromosomal DSBs using the error-prone non-homologous end joining(NHEJ)system and ultimately cause genome mutagenesis.Here,we demonstrated that Enterobacteria phage T4 DNA ligase alone is capable of mediating in vivo chromosome DSBs repair in Escherichia coli.The ligation efficiency of DSBs with T4 DNA ligase is one order of magnitude higher than the NHEJ system from Mycobacterium tuberculosis.This process introduces chromosome DNA excision with different sizes,which can be manipulated by regulating the activity of host-exonuclease RecBCD.The DNA deletion length reduced either by inactivating recB or expressing the RecBCD inhibitor Gam protein fromλphage.Furthermore,we also found single nucleotide substitutions at the DNA junction,suggesting that T4 DNA ligase,as a single component non-homologous end joining system,has great potential in genome mutagenesis,genome reduction and genome editing. | Tianyuan Su Fapeng Liu Yizhao Chang Qi Guo Junshu Wang Qian Wang Qingsheng Qi | 2019 | Synthetic and Systems Biotechnology2019，4，2： | 0 |
| 15 | PCA-LSTM:An Impulsive Ground-Shaking Identification Method Based on Combined Deep Learning显示文摘Near-fault impulsive ground-shaking is highly destructive to engineering structures,so its accurate identification ground-shaking is a top priority in the engineering field.However,due to the lack of a comprehensive consideration of the ground-shaking characteristics in traditional methods,the generalization and accuracy of the identification process are low.To address these problems,an impulsive ground-shaking identification method combined with deep learning named PCA-LSTM is proposed.Firstly,ground-shaking characteristics were analyzed and groundshaking the data was annotated using Baker’smethod.Secondly,the Principal Component Analysis(PCA)method was used to extract the most relevant features related to impulsive ground-shaking.Thirdly,a Long Short-Term Memory network(LSTM)was constructed,and the extracted features were used as the input for training.Finally,the identification results for the Artificial Neural Network(ANN),Convolutional Neural Network(CNN),LSTM,and PCA-LSTMmodels were compared and analyzed.The experimental results showed that the proposed method improved the accuracy of pulsed ground-shaking identification by>8.358%and identification speed by>26.168%,compared to other benchmark models ground-shaking. | Yizhao Wang | 2024 | Computer Modeling in Engineering & Sciences2024，139，6： | 0 |
| 16 | Reprogrammed astrocytes display higher neurogenic competence, migration ability and cell death resistance than reprogrammed fibroblasts显示文摘The direct reprogramming of somatic cells into induced neural progenitor cells(iNPCs)has been envisioned as a promising approach to overcome ethical and clinical issues of pluripotent stem cell transplantation.We previously reported that astrocyte-derived induced pluripotent stem cells(iPSCs)have more tendencies for neuronal differentiation than fibroblast-derived iPSCs.However,the differences of neurogenic potential between astrocytederived iNPCs(AiNPCs)and iNPCs from non-neural origins,such as fibroblast-derived iNPCs(FiNPCs),and the underlying mechanisms remain unclear.Our results suggested that AiNPCs exhibited higher differentiation efficiency,mobility and survival capacities,compared to FiNPCs.The whole transcriptome analysis revealed higher activities of TGFβsignaling in AiNPCs,versus FiNPCs,following a similar trend between astrocytes and fibroblasts.The higher neurogenic competence,migration ability,and cell death resistance of AiNPCs could be abrogated using TGFβ signaling inhibitor LY2157299.Hence,our study demonstrates the difference between iNPCs generated from neural and non-neural cells,together with the underlying mechanisms,which,provides valuable information for donor cell selection in the reprogramming approach. | Xiaohuan Xia Chunhong Li Yi Wang Xiaobei Deng Yizhao Ma Lu Ding Jialin Zheng | 2020 | Translational Neurodegeneration2020，9，1： | 0 |
| 17 | An Urban Road Risk Assessment Framework Based on Convolutional Neural Networks显示文摘In contemporary cities,road collapse is one of the most common disasters.This study proposed a framework for assessing the risk of urban road collapse.The framework first established a risk indicator system that combined environmental and anthropogenic factors,such as soil type,pipeline,and construction,as well as other indicators.Second,an oversampling technique was used to create the dataset.The framework then constructed and trained a convolutional neural network(CNN)-based model for risk assessment.The experimental results show that the CNN model(accuracy:0.97,average recall:0.91)outperformed other models.The indicator contribution analysis revealed that the distance between the road and the construction site(contribution:0.132)and the size of the construction(contribution:0.144)are the most significant factors contributing to road collapse.According to the natural breaks,a road collapse risk map of Foshan City,Guangdong Province,was created,and the risk level was divided into five categories.Nearly 3%of the roads in the study area are at very high risk,and 6%are at high risk levels,with the high risk roads concentrated in the east and southeast.The risk map produced by this study can be utilized by local authorities and policymakers to help maintain road safety. | Juncai Jiang Fei Wang Yizhao Wang Wenyu Jiang Yuming Qiao Wenfeng Bai Xinxin Zheng | 2023 | International Journal of Disaster Risk Science2023，14，3： | 0 |
| 18 | Evaluation of the Shallow Gas Hydrate Production Based on the Radial Drilling-Heat Injection-Back Fill Method显示文摘It has been evidenced that shallow gas hydrate resources are abundant in deep oceans worldwide.Their geological back-ground,occurrence,and other characteristics differ significantly from deep-seated hydrates.Because of the high risk of well construction and low production efficiency,they are difficult to be recovered by using conventional oil production methods.As a result,this paper proposes an alternative design based on a combination of radial drilling,heat injection,and backfilling methods.Multi-branch holes are used to penetrate shallow gas hydrate reservoirs to expand the depressurization area,and heat injection is utilized as a supplement to improve gas production.Geotechnical information collected from an investigation site close to the offshore production well in the South China Sea is used to assess the essential components of this plan,including well construction stability and gas production behavior.It demonstrates that the hydraulic fracturing of the 60mbsf overburden layer can be prevented by regulating the drilling fluid densities.However,the traditional well structure is unstable,and the suction anchor is advised for better mechanical performance.The gas produc-tion rate can be significantly increased by combining hot water injection and depressurization methods.Additionally,the suitable produc-tion equipment already in use is discussed. | CHEN Qiang WAN Yizhao WU Nengyou SUN Jianye WANG Jian LIU Changling LI Yanlong LI Chengfeng HU Gaowei | 2024 | Journal of Ocean University of China2024，23，1： | 0 |
| 19 | Behavior and respiration responses of the earthworm Eisenia fetida to soil arsenite pollution显示文摘Soil arsenic(As)pollution from mining and industrial sources is a serious issue in China.Earthworms are considered ecosystem engineers and contribute to soil fertility development and maintenance of soil physico-chemical properties.In this study,earthworms were exposed to soils with different sodium arsenite concentrations(0,5,20,and 80 mg As kg^(-1))for 60 d to investigate the changes in soil properties and the responses of the earthworms(e.g.,burrowing activity and respiration).Earthworm burrowing activity decreased with increasing arsenite concentrations,and earthworm respiration was significantly lower in soils with 20 and 80 mg As kg^(-1) compared to 0 mg As kg^(-1).Changes in soil properties were also observed after incubation of As-amended soil with earthworms.Specifically,soil pH decreased,while soil electrical conductivity and contents of soil NH3--N,Olsen-P,and available K increased.Our results suggest that arsenite negatively impacts the metabolic activity of earthworms,leading to reduced burrowing activity,which in turn modifies the effects of earthworms on soil fertility and remediation. | Yali WANG Yizhao WU Jo CAVANAGH Xiuhong WANG Jiangping QIU Yinsheng LI | 2021 | Pedosphere2021，31，3： | 0 |
| 20 | Effects of low molecular weight heparin-superoxide dismutase conjugate on serum levels of nitric oxide,glutathione peroxidase,and myeloperoxidase in a gerbil model of cerebral ischemia/reperfusion injury显示文摘BACKGROUND:Several studies have demonstrated that low molecular weight heparin-superoxide dismutase (LMWH-SOD) conjugate may exhibit good neuroprotective effects on cerebral ischemia/reperfusion injury though anticoagulation,decreasing blood viscosity,having anti-inflammatory activity,and scavenging oxygen free radicals. OBJECTIVE: To investigate the intervention effects of LMWH-SOD conjugate on serum levels of nitric oxide (NO),glutathione peroxidase (GSH-Px),and myeloperoxidase (MPO) following cerebral ischemia/reperfusion injury. DESIGN,TIME AND SETTING: A randomized,controlled,and neurobiochemical experiment was performed at the Institute of Biochemical Pharmacy,School of Pharmaceutical Sciences,Shandong University between April and July 2004. MATERIALS: A total of 60 Mongolian gerbils of either gender were included in this study. Total cerebral ischemia/reperfusion injury was induced in 50 gerbils by occluding bilateral common carotid arteries. The remaining 10 gerbils received a sham-operation (sham-operated group). Kits of SOD,NO,and MPO were sourced from Nanjing Jiancheng Bioengineering Institute,China. LMWH,SOD,and LMWH-SOD conjugates were provided by Institute of Biochemistry and Biotechnique,Shandong University,China. METHODS: Fifty successful gerbil models of total cerebral ischemia/reperfusion injury were evenly randomized to five groups: physiological saline,LMWH-SOD,SOD,LMWH + SOD,and LMWH. At 2 minutes prior to ischemia,0.5 mL/65 g physiological saline,20 000 U/kg LMWH-SOD conjugate,20 000 U/kg SOD,a mixture of SOD (20 000 U/kg) and LMWH (LMWH dose calculated according to weight ratio,LMWH: SOD=23.6:51),and LMWH (dose as in the LMWH + SOD group) were administered through the femoral artery in each above-mentioned group,respectively. MAIN OUTCOME MEASURES: Serum levels of NO,MPO,and GSH-Px. RESULTS: Compared with 10 sham-operated gerbils,the cerebral ischemia/reperfusion injury gerbils exhibited decreased serum levels of GSH-Px and increased serum levels of NO and MPO (P<0.01). The serum level of GSH-Px was significantly upregulated in all groups,in particular in the LMWH-SOD group (P<0.01),compared with the physiological saline group (P<0.05-0.01). Following medical treatment,serum levels of NO and MPO were significantly downregulated in all groups,in particular in the LMWH-SOD group (P<0.01). Serum levels of GSH-Px,NO,and MPO in the LMWH-SOD group were close to those in the sham-operated group (P > 0.05). CONCLUSION: In cerebral ischemia/reperfusion injury,LMWH-SOD conjugate exhibits stronger neuroprotective effects on free radical scavenging,inflammation inhibition,and cytotoxicity inhibition than simple or combined application of LMWH and SOD by downregulating NO and MPO levels and upregulating the GSH-Px level. | Qingde Wang Guixiang Cui Hongxia Liu Yizhao Li Fengshan Wang | 2008 | Neural Regeneration Research2008，3，11： | 0 |
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