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| 1 | Moisture-resistant,stretchable NO_(x)gas sensors based on laser-induced graphene for environmental monitoring and breath analysis显示文摘The accurate,continuous analysis of healthcare-relevant gases such as nitrogen oxides(NOx)in a humid environment remains elusive for low-cost,stretchable gas sensing devices.This study presents the design and demonstration of a moisture-resistant,stretchable NO_(x)gas sensor based on laser-induced graphene(LIG).Sandwiched between a soft elastomeric substrate and a moisture-resistant semipermeable encapsulant,the LIG sensing and electrode layer is first optimized by tuning laser processing parameters such as power,image density,and defocus distance.The gas sensor,using a needlelike LIG prepared with optimal laser processing parameters,exhibits a large response of 4.18%o ppm^(-1)to NO and 6.66%o ppm^(-1)to NO_(2),an ultralow detection limit of 8.3 ppb to NO and 4.0 ppb to NO_(2),fast response/recovery,and excellent selectivity.The design of a stretchable serpentine structure in the LIG electrode and strain isolation from the stiff island allows the gas sensor to be stretched by 30%.Combined with a moisture-resistant property against a relative humidity of 90%,the reported gas sensor has further been demonstrated to monitor the personal local environment during dfferent times of the day and analyze human breath samples to classify patients with respiratory diseases from healthy volunteers.Moisture-resistant,stretchable NO_(x)gas sensors can expand the capability of wearable devices to detect biomarkers from humans and exposed environments for early disease diagnostics. | Li Yang Guanghao Zheng Yaoqian Cao Chuizhou Meng Yuhang Li Huadong Ji Xue Chen Guangyu Niu Jiayi Yan Ye Xue Huanyu Cheng | 2022 | Microsystems & Nanoengineering2022，8，4： | 2 |
| 2 | Flowers: precious food and medicine resources显示文摘Flower plants are popular all over the world and important sources of ornamental plants,bioactive molecules and nutrients.Flowers have a wide range of biological activities and beneficial pharmacological effects.Flowers and their active ingredients are becoming more and more popular in the preparation of food,drugs and industrial products.This paper summarizes the active ingredients,pharmacological activities and applications in the pharmaceutical and food industries of flower plants in recent years.In addition,the possible molecular mechanism of pharmacological effects of flower plants were also discussed.302 active constituents from 55 species of flower plants were summarized,including flavonoids(115),terpenoids(90),phenylpropanoids(20),alkaloids(13),organic acids(27)and others(37).The pharmacological effects of flower plants are very extensive,mainly including antioxidant,anti-inflammatory,anti-tumor,anti-virus,and hypoglycemic.The mechanisms of anti-inflammatory,anti-tumor and hypoglycemic activities present the characteristics of multi-way and multi-target.Because of its rich nutrients,bioactive ingredients and plant essential oils,and its wide sources,flower plants are widely used in food,beverage,cosmetics and drug research.Flower plants also play an important role in pharmaceutical industry,food industry and other fields. | Xuqiang Liu Senye Wang Lili Cui Huihui Zhou Yuhang Liu Lijun Meng Sitan Chen Xuefeng Xi Yan Zhang Wenyi Kang | 2023 | Food Science and Human Wellness2023，12，4： | 1 |
| 3 | Research on cable anchorage system modeling methods for self-anchored suspension bridges with steel box girders 显示文摘 | Nie Jianguo Zhou Meng Wang Yuhang Fan Jiansheng Tao Muxuan | 2014 | ASCE Journal of Bridge Engineering2014，19，2： | 1 |
| 4 | The prospect and challenges of sodium-ion batteries for low-temperature conditions显示文摘In recent years,considerable attention has been focused on the development of sodium-ion batteries(SIBs)because of the natural abundance of raw materials and the possibility of low cost,which can alleviate the concerns of the limited lithium resources and the increasing cost of lithium-ion batteries.With the growing demand for reliable electric energy storage devices,requirements have been proposed to further increase the comprehensive performance of SIBs.Especially,the low-temperature tolerance has become an urgent technical obstacle in the practical application of SIBs,because the low operating temperature will lead to sluggish electrochemical reaction kinetics and unstable interfacial reactions,which will deteriorate the performance and even cause safety issues.On the basis of the charge-storage mechanism of SIBs,optimization of the composition and structure of electrolyte and electrode materials is crucial to building SIBs with high performance at low temperatures.In this review,the recent research progress and challenges were systematically summarized in terms of electrolytes and cathode and anode materials for SIBs operating at low temperatures.The typical full-cell configurations of SIBs at low temperatures were introduced to shed light on the fundamental research and the exploitation of SIBs with high performance for practical applications. | Meng Wang Qianchen Wang Xiangyu Ding Yingshuai Wang Yuhang Xin Preetam Singh Feng Wu Hongcai Gao | 2022 | Interdisciplinary Materials2022，1，3： | 1 |
| 5 | CRISPR-powered optothermal nanotweezers:Diverse bio-nanoparticle manipulation and single nucleotide identification显示文摘Optothermal nanotweezers have emerged as an innovative optical manipulation technique in the past decade,which revolutionized classical optical manipulation by efficiently capturing a broader range of nanoparticles.However,the optothermal temperature field was merely employed for in-situ manipulation of nanoparticles,its potential for identifying bio-nanoparticles remains largely untapped.Hence,based on the synergistic effect of optothermal manipulation and CRIPSR-based bio-detection,we developed CRISPR-powered optothermal nanotweezers(CRONT).Specifically,by harnessing diffusiophoresis and thermo-osmotic flows near the substrate upon optothermal excitation,we successfully trapped and enriched DNA functionalized gold nanoparticles,CRISPR-associated proteins,as well as DNA strands.Remarkably,we built an optothermal scheme for enhancing CRISPR-based single-nucleotide polymorphism(SNP)detection at single molecule level,while also introducing a novel CRISPR methodology for observing nucleotide cleavage.Therefore,this innovative approach has endowed optical tweezers with DNA identification ability in aqueous solution which was unattainable before.With its high specificity and feasibility for in-situ bio-nanoparticle manipulation and identification,CRONT will become a universal tool in point-of-care diagnosis,biophotonics,and bio-nanotechnology. | Jiajie Chen Zhi Chen Changle Meng Jianxing Zhou Yuhang Peng Xiaoqi Dai Jingfeng Li Yili Zhong Xiaolin Chen Wu Yuan Ho-Pui Ho Bruce Zhi Gao Junle Qu Xueji Zhang Han Zhang Yonghong Shao | 2023 | Light(Science & Applications)2023，12，12： | 0 |
| 6 | Analysis of Flowing and Heat Transfer of Commercial Molten Nitrate in Porous Foundation Material显示文摘The leakage accident of molten salt in the thermal storage tank will cause the shutdown and enormous economic losses of Concentrated Solar Power plants.This study investigates the heat transfer and flow characteristic of commercial molten nitrates leaking in the thermal state porous foundation material.The migration width and depth of three molten nitrates,Solar Salt(60 wt%NaNO_(3)-40 wt%KNO_(3)),Hitec XL(7 wt%NaNO_(3)-45 wt%KNO_(3)-48 wt%Ca(NO_(3))_(2))and Hitec(7 wt%NaNO_(3)-53 wt%KNO_(3)-40 wt%NaNO_(2)),are obtained at different operating temperatures.Experimental results indicate that the temperature rising rate of foundation material in the nitrate leaking process has a trend of first increasing rapidly and then decreasing,and then it increases slightly as the depth increases.The temperature rising rate increases obviously with increasing operating temperature of the molten salt.With the increase of the operating temperature,the distances from the storage tank bottom to solid salt in foundation and the total migration depths both increase obviously,while the average migrating widths change slightly.At the same operating temperature,the temperature rising rate of the foundation material where Hitec XL and Hitec salt leak is significantly greater than that with Solar Salt,which is closely related to the melting points of molten salts.The migration depth of Hitec is 95.03%greater than that of Solar Salt and 19.11%larger than that of Hitec XL at the operating temperature of 300℃.Compared with Hitec XL,the leakage of Hitec with a smaller viscosity has a larger temperature rising rate and a wider and deeper transporting range during the leakage process.This work could guide the installation locations of the leak detection devices for high temperature storage tank and the environmental treatment of leaking accident. | SHI Hua ZHOU Hao MENG Hanxiao LV Laiquan LIU Tianxiao ZUO Yuhang CEN Kefa | 2023 | Journal of Thermal Science2023，32，4： | 0 |
| 7 | Feasibility and physics potential of detecting ^(8)B solar neutrinos at JUNO显示文摘The Jiangmen Underground Neutrino Observatory(JUNO)features a 20 kt multi-purpose underground liquid scintillator sphere as its main detector.Some of JUNO's features make it an excellent location for^8B solar neutrino measurements,such as its low-energy threshold,high energy resolution compared with water Cherenkov detectors,and much larger target mass compared with previous liquid scintillator detectors.In this paper,we present a comprehensive assessment of JUNO's potential for detecting^8B solar neutrinos via the neutrino-electron elastic scattering process.A reduced 2 MeV threshold for the recoil electron energy is found to be achievable,assuming that the intrinsic radioactive background^(238)U and^(232)Th in the liquid scintillator can be controlled to 10^(-17)g/g.With ten years of data acquisition,approximately 60,000 signal and 30,000 background events are expected.This large sample will enable an examination of the distortion of the recoil electron spectrum that is dominated by the neutrino flavor transformation in the dense solar matter,which will shed new light on the inconsistency between the measured electron spectra and the predictions of the standard three-flavor neutrino oscillation framework.IfDelta m^(2)_(21)=4.8times10^(-5);(7.5times10^(-5))eV^(2),JUNO can provide evidence of neutrino oscillation in the Earth at approximately the 3sigma(2sigma)level by measuring the non-zero signal rate variation with respect to the solar zenith angle.Moreover,JUNO can simultaneously measureDelta m^2_(21)using^8B solar neutrinos to a precision of 20% or better,depending on the central value,and to sub-percent precision using reactor antineutrinos.A comparison of these two measurements from the same detector will help understand the current mild inconsistency between the value of Delta m^2_(21)reported by solar neutrino experiments and the KamLAND experiment. | Angel Abusleme Thomas Adam Shakeel Ahmad Sebastiano Aiello Muhammad Akram Nawab Ali Fengpeng An Guangpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Andrej Babic Wander Baldini Andrea Barresi Eric Baussan Marco Bellato Antonio Bergnoli Enrico Bernieri David Biare Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Max Buesken Mario Buscemi Jose Busto Ilya Butorov Anatael Cabrera Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Jinfan Chang Yun Chang Pingping Chen Po-An Chen Shaomin Chen Shenjian Chen Xurong Chen Yi-Wen Chen Yixue Chen Yu Chen Zhang Chen Jie Cheng Yaping Cheng Alexander Chepurnov Davide Chiesa Pietro Chimenti Artem Chukanov Anna Chuvashova Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Salvatore Costa Flavio Dal Corso Christophe De La Taille Jiawei Deng Zhi Deng Ziyan Deng Wilfried Depnering Marco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Georgy Donchenko Jianmeng Dong Damien Dornic Evgeny Doroshkevich Marcos Dracos Frédéric Druillole Shuxian Du Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Lukas Fajt Donghua Fan Lei Fan Can Fang Jian Fang Marco Fargetta Anna Fatkina Dmitry Fedoseev Vladko Fekete Li-Cheng Feng Qichun Feng Richard Ford Andrey Formozov Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Alexandre Göttel Christoph Genster Marco Giammarchi Agnese Giaz Nunzio Giudice Franco Giuliani Maxim Gonchar Guanghua Gong Hui Gong Oleg Gorchakov Yuri Gornushkin Marco Grassi Christian Grewing Maxim Gromov Vasily Gromov Minghao Gu Xiaofei Gu Yu Gu Mengyun Guan Nunzio Guardone Maria Gul Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yang Han Miao He Wei He Tobias Heinz Patrick Hellmuth Yuekun Heng Rafael Herrera Daojin Hong YuenKeung Hor Shaojing Hou Yee Hsiung Bei-Zhen Hu Hang Hu Jianrun Hu Jun Hu Shouyang Hu Tao Hu Zhuojun Hu Chunhao Huang Guihong Huang Hanxiong Huang Qinhua Huang Wenhao Huang Xingtao Huang Yongbo Huang Jiaqi Hui Wenju Huo Cédric Huss Safeer Hussain Antonio Insolia Ara Ioannisian Daniel Ioannisyan Roberto Isocrate Kuo-Lun Jen Xiaolu Ji Xingzhao Ji Huihui Jia Junji Jia Siyu Jian Di Jiang Xiaoshan Jiang Ruyi Jin Xiaoping Jing Cécile Jollet Jari Joutsenvaara Sirichok Jungthawan Leonidas Kalousis Philipp Kampmann Li Kang Michael Karagounis Narine Kazarian Amir Khan Waseem Khan Khanchai Khosonthongkee Patrick Kinz Denis Korablev Konstantin Kouzakov Alexey Krasnoperov Svetlana Krokhaleva Zinovy Krumshteyn Andre Kruth Nikolay Kutovskiy Pasi Kuusiniemi Tobias Lachenmaier Cecilia Landini Sébastien Leblanc Frederic Lefevre Liping Lei Ruiting Lei Rupert Leitner Jason Leung Demin Li Fei Li Fule Li Haitao Li Huiling Li Jiaqi Li Jin Li Kaijie Li Mengzhao Li Nan Li Nan Li Qingjiang Li Ruhui Li Shanfeng Li Shuaijie Li Tao Li Weidong Li Weiguo Li Xiaomei Li Xiaonan Li Xinglong Li Yi Li Yufeng Li Zhibing Li Ziyuan Li Hao Liang Hao Liang Jingjing Liang Jiajun Liao Daniel Liebau Ayut Limphirat Sukit Limpijumnong Guey-Lin Lin Shengxin Lin Tao Lin Jiajie Ling Ivano Lippi Fang Liu Haidong Liu Hongbang Liu Hongjuan Liu Hongtao Liu Hu Liu Hui Liu Jianglai Liu Jinchang Liu Min Liu Qian Liu Qin Liu Runxuan Liu Shuangyu Liu Shubin Liu Shulin Liu Xiaowei Liu Yan Liu Alexey Lokhov Paolo Lombardi Claudio Lombardo Kai Loo Chuan Lu Haoqi Lu Jingbin Lu Junguang Lu Shuxiang Lu Xiaoxu Lu Bayarto Lubsandorzhiev Sultim Lubsandorzhiev Livia Ludhova Fengjiao Luo Guang Luo Pengwei Luo Shu Luo Wuming Luo Vladimir Lyashuk Qiumei Ma Si Ma Xiaoyan Ma Xubo Ma Jihane Maalmi Yury Malyshkin Fabio Mantovani Francesco Manzali Xin Mao Yajun Mao Stefano MMari Filippo Marini Sadia Marium Cristina Martellini Gisele Martin-Chassard Agnese Martini Davit Mayilyan Axel Müller Ints Mednieks Yue Meng Anselmo Meregaglia Emanuela Meroni David Meyhöfer Mauro Mezzetto Jonathan Miller Lino Miramonti Salvatore Monforte Paolo Montini Michele Montuschi Nikolay Morozov Pavithra Muralidharan Massimiliano Nastasi Dmitry VNaumov Elena Naumova Igor Nemchenok Alexey Nikolaev Feipeng Ning Zhe Ning Hiroshi Nunokawa Lothar Oberauer Juan Pedro Ochoa-Ricoux Alexander Olshevskiy Domizia Orestano Fausto Ortica Hsiao-Ru Pan Alessandro Paoloni Nina Parkalian Sergio Parmeggiano Teerapat Payupol Yatian Pei Nicomede Pelliccia Anguo Peng Haiping Peng Frédéric Perrot Pierre-Alexandre Petitjean Fabrizio Petrucci Luis Felipe Piñeres Rico Oliver Pilarczyk Artyom Popov Pascal Poussot Wathan Pratumwan Ezio Previtali Fazhi Qi Ming Qi Sen Qian Xiaohui Qian Hao Qiao Zhonghua Qin Shoukang Qiu Muhammad Rajput Gioacchino Ranucci Neill Raper Alessandra Re Henning Rebber Abdel Rebii Bin Ren Jie Ren Taras Rezinko Barbara Ricci Markus Robens Mathieu Roche Narongkiat Rodphai Aldo Romani Bedřich Roskovec Christian Roth Xiangdong Ruan Xichao Ruan Saroj Rujirawat Arseniy Rybnikov Andrey Sadovsky Paolo Saggese Giuseppe Salamanna Simone Sanfilippo Anut Sangka Nuanwan Sanguansak Utane Sawangwit Julia Sawatzki Fatma Sawy Michaela Schever Jacky Schuler Cédric Schwab Konstantin Schweizer Dmitry Selivanov Alexandr Selyunin Andrea Serafini Giulio Settanta Mariangela Settimo Muhammad Shahzad Vladislav Sharov Gang Shi Jingyan Shi Yongjiu Shi Vitaly Shutov Andrey Sidorenkov FedorŠimkovic Chiara Sirignano Jaruchit Siripak Monica Sisti Maciej Slupecki Mikhail Smirnov Oleg Smirnov Thiago Sogo-Bezerra Julanan Songwadhana Boonrucksar Soonthornthum Albert Sotnikov Ondrej Sramek Warintorn Sreethawong Achim Stahl Luca Stanco Konstantin Stankevich DušanŠtefánik Hans Steiger Jochen Steinmann Tobias Sterr Matthias Raphael Stock Virginia Strati Alexander Studenikin Gongxing Sun Shifeng Sun Xilei Sun Yongjie Sun Yongzhao Sun Narumon Suwonjandee Michal Szelezniak Jian Tang Qiang Tang Quan Tang Xiao Tang Alexander Tietzsch Igor Tkachev Tomas Tmej Konstantin Treskov Andrea Triossi Giancarlo Troni Wladyslaw Trzaska Cristina Tuve Stefan van Waasen Johannes van den Boom Guillaume Vanroyen Nikolaos Vassilopoulos Vadim Vedin Giuseppe Verde Maxim Vialkov Benoit Viaud Cristina Volpe Vit Vorobel Lucia Votano Pablo Walker Caishen Wang Chung-Hsiang Wang En Wang Guoli Wang Jian Wang Jun Wang Kunyu Wang Lu Wang Meifen Wang Meng Wang Ruiguang Wang Siguang Wang Wei Wang Wenshuai Wang Xi Wang Xiangyue Wang Yangfu Wang Yaoguang Wang Yi Wang Yifang Wang Yuanqing Wang Yuman Wang Zhe Wang Zheng Wang Zhimin Wang Zongyi Wang Apimook Watcharangkool Lianghong Wei Wei Wei Yadong Wei Liangjian Wen Christopher Wiebusch Steven Chan-Fai Wong Bjoern Wonsak Diru Wu Fangliang Wu Qun Wu Wenjie Wu Zhi Wu Michael Wurm Jacques Wurtz Christian Wysotzki Yufei Xi Dongmei Xia Yuguang Xie Zhangquan Xie Zhizhong Xing Benda Xu Donglian Xu Fanrong Xu Jilei Xu Jing Xu Meihang Xu Yin Xu Yu Xu Baojun Yan Xiongbo Yan Yupeng Yan Anbo Yang Changgen Yang Huan Yang Jie Yang Lei Yang Xiaoyu Yang Yifan Yang Haifeng Yao Zafar Yasin Jiaxuan Ye Mei Ye Ugur Yegin Frédéric Yermia Peihuai Yi Xiangwei Yin Zhengyun You Boxiang Yu Chiye Yu Chunxu Yu Hongzhao Yu Miao Yu Xianghui Yu Zeyuan Yu Chengzhuo Yuan Ying Yuan Zhenxiong Yuan Ziyi Yuan Baobiao Yue Noman Zafar Andre Zambanini Pan Zeng Shan Zeng Tingxuan Zeng Yuda Zeng Liang Zhan Feiyang Zhang Guoqing Zhang Haiqiong Zhang Honghao Zhang Jiawen Zhang Jie Zhang Jingbo Zhang Peng Zhang Qingmin Zhang Shiqi Zhang Tao Zhang Xiaomei Zhang Xuantong Zhang Yan Zhang Yinhong Zhang Yiyu Zhang Yongpeng Zhang Yuanyuan Zhang Yumei Zhang Zhenyu Zhang Zhijian Zhang Fengyi Zhao Jie Zhao Rong Zhao Shujun Zhao Tianchi Zhao Dongqin Zheng Hua Zheng Minshan Zheng Yangheng Zheng Weirong Zhong Jing Zhou Li Zhou Nan Zhou Shun Zhou Xiang Zhou Jiang Zhu Kejun Zhu Honglin Zhuang Liang Zong Jiaheng Zou | 2021 | Chinese Physics C2021，45，2： | 0 |
| 8 | GATA2^(−/−) human ESCs undergo attenuatedendothelial to hematopoietic transition andthereafter granulocyte commitment显示文摘Background: Hematopoiesis is a progressive process collectively controlled by an elaborate network of transcriptionfactors (TFs). Among these TFs, GATA2 has been implicated to be critical for regulating multiple steps of hematopoiesisin mouse models. However, whether similar function of GATA2 is conserved in human hematopoiesis, especially duringearly embryonic development stage, is largely unknown.Results: To examine the role of GATA2 in human background, we generated homozygous GATA2 knockout humanembryonic stem cells (GATA2^(−/−) hESCs) and analyzed their blood differentiation potential. Our results demonstratedthat GATA2^(−/−) hESCs displayed attenuated generation of CD34^(+)CD43^(+) hematopoietic progenitor cells (HPCs), due tothe impairment of endothelial to hematopoietic transition (EHT). Interestingly, GATA2^(−/−) hESCs retained the potentialto generate erythroblasts and macrophages, but never granulocytes. We further identified that SPI1 downregulationwas partially responsible for the defects of GATA2^(−/−) hESCs in generation of CD34^(+)CD43^(+) HPCs and granulocytes.Furthermore, we found that GATA2^(−/−) hESCs restored the granulocyte potential in the presence of Notch signaling.Conclusion: Our findings revealed the essential roles of GATA2 in EHT and granulocyte development throughregulating SPI1, and uncovered a role of Notch signaling in granulocyte generation during hematopoiesis modeled byhuman ESCs. | Ke Huang Juan Du Ning Ma Jiajun Liu Pengfei Wu Xiaoya Dong Minghui Meng Wenqian Wang Xin Chen Xi Shi Qianyu Chen Zhongzhou Yang Shubin Chen Jian Zhang Yuhang Li Wei Li Yi Zheng Jinglei Cai Peng Li Xiaofang Sun Jinyong Wang Duanqing Pei Guangjin Pan | 2015 | Cell Regeneration2015，4，1： | 0 |
| 9 | Effects of Banxiaxiexin Decoction on the SCF Gene Expression in the Stomach Wall of Rat Model of Electrogastric Dysrhythmias显示文摘Objective:To observe the effects of Banxiaxiexin Decoction (BD) on rats with electrogastric dysrhythmias by divided design and discuss the mechanism of BD.Methods:To establish the rat model of electrogastric dysrhythmias and examine effects of BD on the SCF mRNA by reverse transcriptive polymerase chain reaction (RT-PCR).Results:BD and all the divided groups can reduce the mRNA expression of SCF, and show significant difference with model group (P<0.05).Conclusion:The BD treatment of epigastric fullness (to regulate the movement of stomach and intestine) is in connection with adjustment of the mRNA expression of SCF. | Li Yuhang Wang Qingguo Chen Meng Wang Dan Li Lina Zhang Dongmei (Beijing University of Chinese Traditional Medicine,100029,Beijing ) | 2003 | 中医药学刊2003，21，11： | 0 |
| 10 | Simultaneous Determination of 14 β-Receptor Agonists Residues in Mutton by High Performance Liquid Chromatography-Tandem Mass Spectrometry (HPLC-MS/MS)显示文摘[Objectives]A high performance liquid chromatography-tandem mass spectrometry(HPLC-MS/MS)method was established for the determination of 14β-receptor agonist residues in mutton.[Methods]Samples were hydrolyzed byβ-glucuronidase and extracted with 5%acetic acid-acetonitrile(1:99,V/V)solution.An Eclipse plus C 18 column was used for separation,and the MRM mode was used for qualitative analysis,and the external standard method was used for quantitative analysis of matrix standard solutions.[Results]Under the optimal conditions,the retention time of the 14 kinds ofβ-receptor agonists ranged from 1.0 to 9.5 min.When the mass concentration was in the range of 0.05-0.50μg/ml,the linear relationship ofβ-receptor agonists was good,with correlation coefficients(r)≥0.9992.The detection limits of the method were in the range of 0.04-0.87μg/kg,and the quantitative limits were in the range of 0.35-1.86μg/kg.The average recovery values were in the range of 82.8%-108.9%,with RSDs(n=6)in the range of 1.9%-6.7%.[Conclusions]The method is simple,sensitive,reproducible,accurate,and can be used for simultaneous determination of the 14 kinds ofβ-receptor agonist residues in mutton. | Zhe MENG Jianhua WANG Bo LIU Yuhang GUO Haoshuang DONG Pingyang SHAN Dawei WANG Yajuan SONG | 2023 | Agricultural Biotechnology2023，12，5： | 0 |
| 11 | Casein kinase-2 inhibition promotes retinal ganglion cell survival after acute intraocular pressure elevation显示文摘Intraocular pressure elevation can induce retinal ganglion cell death and is a clinically reversible risk factor for glaucoma,the leading cause of irreversible blindness.We previously demonstrated that casein kinase-2 inhibition can promote retinal ganglion cell survival and axonal regeneration in rats after optic nerve injury.To investigate the underlying mechanism,in the current study we increased the intraocular pressure of adult rats to 75 mmHg for 2 hours and then administered a casein kinase-2 inhibitor(4,5,6,7-tetrabromo-2-azabenzimidazole or 2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole)by intravitreal injection.We found that intravitreal injection of 4,5,6,7-tetrabromo-2-azabenzimidazole or 2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole promoted retinal ganglion cell survival and reduced the number of infiltrating macrophages.Transcriptomic analysis showed that the mitogen activated protein kinase signaling pathway was involved in the response to intraocular pressure elevation but was not modulated by the casein kinase-2 inhibitors.Furthermore,casein kinase-2 inhibition downregulated the expression of genes(Cck,Htrsa,Nef1,Htrlb,Prph,Chat,Slc18a3,Slc5a7,Scn1b,Crybb2,Tsga10ip,and Vstm21)involved in intraocular pressure elevation.Our data indicate that inhibition of casein kinase-2 can enhance retinal ganglion cell survival in rats after acute intraocular pressure elevation via macrophage inactivation. | Meng Wang Shi-Qi Yao Yao Huang Jia-Jian Liang Yanxuan Xu Shaowan Chen Yuhang Wang Tsz Kin Ng Wai Kit Chu Qi Cui Ling-Ping Cen | 2024 | Neural Regeneration Research2024，19，5： | 0 |
| 12 | Monte Carlo Study about Rapid Range Verification of Carbon Ion Beam显示文摘In radiotherapy,quality assurance(QA)is an important part to ensure the success of radiotherapy for patients,and an important part of the work for medical physicists.In proton/heavy ion radiation therapy. | Che Yuhang Zhang Hui Meng Qianqian Li Guangru Zhang Xiaofang Dai Zhongying Liu Xinguo Chen Weiqiang Li Qiang | 2019 | IMP & HIRFL Annual Report2019，，1： | 0 |
| 13 | Phytochemical activators of Nrf2:a review of therapeutic strategies in diabetes显示文摘Insulin resistance(IR)is fundamental to the development of type 2 diabetes(T2D),and altered mitochondrial function and abnormal lipid distribution are closely associated with IR or T2D.Excess oxidative stress-induced mitochondrial damage leads to an imbalance in redox homeostasis,which is considered the major contributor to the progression of diabetes.A key cellular defense mechanism,namely,the nuclear factor-E2 p45-related factor 2(Nrf2)-antioxidant response element(ARE)pathway,plays an essential protective role in combating excess oxidative stress.A series of phytochemicals are reported to improve IR and restore mitochondrial function against excess oxidative stress by activating the Nrf2-ARE signaling pathway to maintain cellular reactive oxygen species(ROS)homeostasis.The present review focuses on key knowledge gaps in the Nrf2-ARE system targeted by phytochemicals and its correlation to diabetes both in the in vitro and in vivo models and recent achievements in human clinical trials to evaluate its efficiency and safety.In addition,we provide an overview of recent research progress in nutrigenomics,precision nutrition and the interactions occurring in gut microbiota associated with the Nrf2-ARE signaling pathway and diabetes chemoprevention by phytochemicals and finally propose a future research strategy for regulating redox and microbiota balance via the Nrf2-ARE pathway.The present review aims to help us comprehensively understand the critical chemopreventive role of the Nrf2-ARE pathway targeted by phytochemicals in diabetes. | Si Qin Zhong Chen Yiling Wen Yuhang Yi Chenghao Lv Chaoxi Zeng Lanming Chen Meng Shi | 2023 | Acta Biochimica et Biophysica Sinica2023，55，1： | 0 |
| 14 | Screening for urinary markers predicting hematopoietic stem cell injury induced by busulfan using genetically diverse mice显示文摘Background:Busulfan(BU)is an alkylating agent used as a conditioning agent prior to hematopoietic stem cell(HSC)transplantation as it is known to be cytotoxic to host hematopoietic stem and progenitor cells.The susceptibility of HSCs to BU injury plays an important role in the myeloablative efficacy of BU.Different susceptibilities were demonstrated in genetically diverse(GD)mice in our preliminary research.Methods:Three strains of GD mice with different susceptibilities to BU-i nduced HSC injury were used for screening biological markers of HSC injury susceptibility in urine.The urine proteins were analyzed using liquid chromatography coupled with tandem mass spectrometry to screen for differentially expressed proteins.Screening for possible biomarkers based on differences in protein expression abundance was validated using enzyme-l inked immunoassay(ELISA).Results:Functional analysis showed that the differential proteins were all involved in a series of biological pathways related to cellular senescence,apoptosis,and angiogenesis;whereas the differential proteins of the high-susceptible strain were enriched for the regulation of bone marrow microenvironment pathways,those of low-susceptible strain were enriched for the proapoptotic effect of GTPase pathways.Based on protein abundance differences,several urinary proteins that may be indicative of susceptibility were screened,and ELISA validation results showed that angiotensin-converting enzyme may be a potential biomarker predicting HSC susceptibility for BU conditioning.Conclusions:This study indicates that urinary protein levels can reflect differences in susceptibility to BU-i nduced HSC injury.Using GD mice to construct genetic difference models will provide preclinical data for screening BU-related biological markers. | Yuhang Sun Bowen Guan Xing Liu Lingyan Zhang Xinpei Wang Aimin Meng Ran Gao | 2023 | Animal Models and Experimental Medicine2023，6，2： | 0 |
| 15 | Confinedly implanting Fe_(3)O_(4) nanoclusters on MoS_(2) nanosheets to tailor electromagnetic properties for excellent multi-bands microwave absorption显示文摘High efficiency microwave absorption(MA)materials with tunable electromagnetic(EM)features have been highly sought.However,it is still a challenge to achieve multi-bands absorption performance by simple optimizing the chemical composition of MA materials.Herein,a simple solvothermal method was used to embed magnetic Fe_(3)O_(4) nanodusters on MoS2 nanosheets,in which magnetic nanodusters weme quantitatively customized More importantly,the MA frequency and MA properties of the material are highly tailored,and multi-bands absorption is achieved.The minimum reflection loss(RL)of Fe_(3)O_(4)/MoS_(2) composite reaches-87.24 dB and is about 4 times more than pure MoS_(2) nanosheets.The effective ab-sorption bandwidth reaches 5.52 GHz(≤-10 dB).These desirable properties result from the introduction of appropriate magnetic Fe_(3)O_(4) nanoclusters,which provide optimal synegistic effect of dielectric and magnetic losses.This result provides a feasible idea for designing high efficiency MA materials with tunable EM features in the future. | Meng Ma Qi Zheng Yuhang Zhu Lin Li Maosheng Cao | 2022 | Journal of Materiomics2022，8，3： | 0 |
| 16 | A Dual Model Watermarking Framework for Copyright Protection in Image Processing Networks显示文摘Image processing networks have gained great success in many fields,and thus the issue of copyright protection for image processing networks hasbecome a focus of attention. Model watermarking techniques are widely usedin model copyright protection, but there are two challenges: (1) designinguniversal trigger sample watermarking for different network models is stilla challenge;(2) existing methods of copyright protection based on trigger swatermarking are difficult to resist forgery attacks. In this work, we propose adual model watermarking framework for copyright protection in image processingnetworks. The trigger sample watermark is embedded in the trainingprocess of the model, which can effectively verify the model copyright. And wedesign a common method for generating trigger sample watermarks based ongenerative adversarial networks, adaptively generating trigger sample watermarksaccording to different models. The spatial watermark is embedded intothe model output. When an attacker steals model copyright using a forgedtrigger sample watermark, which can be correctly extracted to distinguishbetween the piratical and the protected model. The experiments show that theproposed framework has good performance in different image segmentationnetworks of UNET, UNET++, and FCN (fully convolutional network), andeffectively resists forgery attacks. | Yuhang Meng Xianyi Chen Xingming Sun Yu Liu Guo Wei | 2023 | Computers, Materials & Continua2023，，4： | 0 |
| 17 | Trajectory-tracking control of an unmanned surface vehicle based on characteristic modelling approach:Implementation and field testing显示文摘In this study,a practical adaptive control scheme is proposed for the trajectory tracking of an unmanned surface vehicle via the characteristic modelling approach.Therefore,accurate tracking control can be achieved in the presence of unknown time‐varying model parameters and environmental disturbances.The control scheme comprises a trajectory guidance module based on the virtual target approach and a tracking control module designed by characteristic modelling theory.Firstly,the ideal control commands of the yaw speed and surge speed are generated using the position errors between the vehicle and the virtual target.Then,a second‐order characteristic model for the heading and surge speed channel is developed.The parameters of the model are updated by a real‐time parameter identification algorithm.Based on this model,an integrated adaptive control law is designed which consists of golden‐section control,feed‐forward control and integral control.Finally,the development processes of the vehicle platform and the control algorithms are described,and the results of simulation and field experiments are presented and discussed. | Yuhang Meng Hui Ye Xiaofei Yang | 2023 | IET Cyber-Systems and Robotics2023，5，2： | 0 |
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